CN107412274A - A kind of probiotics medicine for treating constipation and preparation method thereof - Google Patents
A kind of probiotics medicine for treating constipation and preparation method thereof Download PDFInfo
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- CN107412274A CN107412274A CN201710702266.4A CN201710702266A CN107412274A CN 107412274 A CN107412274 A CN 107412274A CN 201710702266 A CN201710702266 A CN 201710702266A CN 107412274 A CN107412274 A CN 107412274A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/745—Bifidobacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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Abstract
The invention belongs to drug field, and in particular to a kind of probiotics medicine for treating constipation and preparation method thereof, the medicine includes the raw material of following weight proportion：10 40 parts of lactobacillus acidophilus bacterium powder, 10 40 parts of Lactobacillus casei bacterium powder, 10 40 parts of bifidobacterium lactis bacterium powder, 1 10 parts of vitamin C, 24 34 parts of FOS, 10 40 parts of skimmed milk power, 5 15 parts of 2 12 parts of maltodextrin, 2 12 parts of lactose and inulin, by probiotics bacterium powder and vitamin C, glucose and skimmed milk power, maltodextrin, lactose and inulin formulated in combination, prescription is rigorous, compatibility science, it is evident in efficacy, energy both symptoms and root causes, treat rapidly and fundamentally constipation.
Description
Technical field
The invention belongs to drug field, and in particular to a kind of probiotics medicine for treating constipation and preparation method thereof.
Background technology
At present, the main performance of constipation is that defecation frequency is reduced and difficult defecation, some patients can the highlightedly rows of showing as
Just difficult, the long or daily defecation of defecation time is multiple, but discharges difficulty, and quantity is seldom.In addition, have abdominal distension, anorexia, with
And take that cathartic is improper to cause stomachache etc. before defecation.The main reason for causing constipation have bad life habits, psychologic factors,
The causes of disease such as enteron aisle lesion, medicine are mainly antibiosis anti-inflammatory drug, Chinese medicine, Western medicine, probiotics etc., but curative effect respectively have it is deficient
Lack, doctor trained in Western medicine can not treat both principal and secondary aspect of disease, and side effect is obvious, and the traditional Chinese medical science course for the treatment of is longer, is extremely difficult to good result in a short time.It is accordingly, it is capable to fast
It is clinical great difficult problem in the urgent need to address that speed, which mitigates medicine that is ailing and fundamentally curing constipation and be free from side effects,.
The content of the invention
In order to solve this problem, the present invention provides a kind of probiotics medicine for treating constipation and preparation method thereof, by benefit
Raw bacterium bacterium powder and vitamin C, glucose and skimmed milk power, maltodextrin, lactose and inulin formulated in combination, prescription is rigorous, compatibility
Science, it is evident in efficacy, energy both symptoms and root causes, treat rapidly and fundamentally constipation.
Technical scheme is used by order to solve its technical problem：
A kind of probiotics medicine for treating constipation, include the raw material of following weight proportion：Lactobacillus acidophilus bacterium powder 10-40 parts, do
It is Lactobacillus paracasei bacterium powder 10-40 parts, bifidobacterium lactis bacterium powder 10-40 parts, vitamin C 1-10 parts, FOS 24-34 parts, de-
Fat milk powder 10-40 parts, maltodextrin 2-12 parts, lactose 2-12 parts and inulin 5-15 parts, total viable count is 1 × 107Cfu/g with
On.
The formulation of above-mentioned probiotics medicine is oral formulations.
The formulation of above-mentioned probiotics medicine is capsule or powder formulation.
The preparation method of the probiotics medicine of above-mentioned treatment constipation, comprises the following steps：
A, strain is selected：Select Lactobacillus acidophilus species；
B, the production of hybrid seeds：Sterile environment is selected, strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium,
Then seal bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, sterilize：100 liters of fermentation tanks are subjected to empty elimination bacterium, culture medium is then placed in and is sterilized, 121 degrees Celsius of sterilising temp
More than, pressure inside the tank 0.12MPa, continue 20min sterilizings and terminate, temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure
Power is down to 0.01MPa；
D, it is inoculated with：The seed in incubator is put into desinfection chamber first and is sampled microscopy, growth selection it is good be inoculated with,
Turn on inoculation mouth closure, toward 100 liters of tanks in lead to micro filtrated air, ensure pressure inside the tank will not be zero, with inoculation flame ring
Inoculation mouth is placed on, after lighting flame ring, inoculation lid is opened completely, then triangular flask is placed on above flame ring, open three
Angle bottle, seed is poured into tank, tightens inoculation lid after terminating, filtrated air is led into tank, pressure inside the tank is stopped to 0.06MPa
Only, pressurize is carried out, temperature is kept for 37 DEG C, the MPa of pressure 0.06, and speed of agitator is adjusted to 60r/min, cultivates 12 hours；
E, culture transferring：Step b, the pipeline that the strain in 100 liters of fermentation tank then is passed through into sterilizing are carried out to 1000 liters of fermentation tanks
Moving in 1000 liters of fermentation tanks for preparing culture medium, temperature is kept for 37 DEG C, and the MPa of pressure 0.06, speed of agitator is adjusted to 60r/min,
Cultivate 12 hours, side viable count is sampled after growth well in 1000 liters of fermentation tanks；
F, centrifuge：Bacterium solution is turned clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed
After take out bacterium mud；
G, freeze：Bacterium mud is placed in the flaggy of freeze dryer, carries out lyophilized operation, -45 DEG C of freeze dryer rear lane temperature is taken out
Vacuum；
H, crush：Bacterium powder is obtained after crushing；
I, cheese-making lactobacillus bacterium powder and bifidobacterium lactis bacterium powder：By lactobacillus acidophilus, bifidobacterium lactis repeat step b to step
H, obtain Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium powder；
J, manufactured goods：By bacterium powder and vitamin C, FOS, skimmed milk power, maltodextrin, lactose and inulin according to the medicine
Thing weight proportion configures, and capsule is made after well mixed or granule bag is made.
The effect of the various probiotics of the present invention is as follows：
Lactobacillus acidophilus：One of people and animal intestinal tract normal flora, suppress harmful bacteria growing, promote intestinal beneficial bacteria growing, adjust
Whole disorderly intestinal microecology system；
Lactobacillus casei：Strengthen nonspecific resistance of the host to microbial pathogens, accelerate to remove intestinal pathogens, control
Enteric flora disturbance and enhancing enteron aisle permeability are treated, regulation intestinal flora balance is played, promotes human consumption to absorb；
Bifidobacterium lactis：Lactic acid and acetic acid are produced, has the function that to adjust gut flora, has fostered the ancestral home bacterium in enteron aisle, made
Body colonization resistance raises, and is advantageous to the field planting of antagonism pathogenic bacteria and conditioned pathogen, has good work to treatment chronic diarrhea
With.
The beneficial effects of the invention are as follows：The present invention compared with the existing simple Chinese medicine of in the market, Western medicine and probiotics,
Both enteron aisle, which can have been nursed one's health, inherently improves human body constitution, can adjust the intestinal microecology system of disorder rapidly again, directly repair
Impaired intestinal mucosa again, intestinal immunity is improved, is treated both principal and secondary aspect of disease.The effect of fundamentally playing prevention and treatment constipation.
Embodiment
Embodiment 1：
A kind of probiotics medicine for treating constipation, include the raw material of following weight proportion：10 parts of lactobacillus acidophilus bacterium powder, cheese breast
10 parts of bacillus bacterium powder, 10 parts of bifidobacterium lactis bacterium powder, 1 part of vitamin C, 24 parts of glucose, 10 parts of skimmed milk power, maltodextrin
5 parts of 2 parts, 2 parts of lactose and inulin, total viable count is 2 × 107cfu/g。
The preparation method of the probiotics medicine of above-mentioned treatment constipation, comprises the following steps：
A, strain is selected：Select Lactobacillus acidophilus species；
B, the production of hybrid seeds：Sterile environment is selected, strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium,
Then seal bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, sterilize：100 liters of fermentation tanks are subjected to empty elimination bacterium, culture medium is then placed in and is sterilized, 121 degrees Celsius of sterilising temp
More than, pressure inside the tank 0.12MPa, continue 20min sterilizings and terminate, temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure
Power is down to 0.01MPa；
D, it is inoculated with：The seed in incubator is put into desinfection chamber first and is sampled microscopy, growth selection it is good be inoculated with,
Turn on inoculation mouth closure, toward 100 liters of tanks in lead to micro filtrated air, ensure pressure inside the tank will not be zero, with inoculation flame ring
Inoculation mouth is placed on, after lighting flame ring, inoculation lid is opened completely, then triangular flask is placed on above flame ring, open three
Angle bottle, seed is poured into tank, tightens inoculation lid after terminating, filtrated air is led into tank, pressure inside the tank is stopped to 0.06MPa
Only, pressurize is carried out, temperature is kept for 37 DEG C, the MPa of pressure 0.06, and speed of agitator is adjusted to 60r/min, cultivates 12 hours；
E, culture transferring：Step b, the pipeline that the strain in 100 liters of fermentation tank then is passed through into sterilizing are carried out to 1000 liters of fermentation tanks
Moving in 1000 liters of fermentation tanks for preparing culture medium, temperature is kept for 37 DEG C, and the MPa of pressure 0.06, speed of agitator is adjusted to 60r/min,
Cultivate 12 hours, side viable count is sampled after growth well in 1000 liters of fermentation tanks；
F, centrifuge：Bacterium solution is turned clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed
After take out bacterium mud；
G, freeze：Bacterium mud is placed in the flaggy of freeze dryer, carries out lyophilized operation, -45 DEG C of freeze dryer rear lane temperature is taken out
Vacuum；
H, crush：Bacterium powder is obtained after crushing；
I, cheese-making lactobacillus bacterium powder and bifidobacterium lactis bacterium powder：By lactobacillus acidophilus, bifidobacterium lactis repeat step b to step
H, obtain Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium powder；
H, manufactured goods：By lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder, bifidobacterium lactis bacterium powder and vitamin C, oligomeric fruit
Sugar, skimmed milk power, maltodextrin, lactose and inulin are matched according to the drug weight and configured, and capsule is made i.e. after well mixed
Can.
Embodiment 2：
A kind of probiotics medicine for treating constipation, include the raw material of following weight proportion：40 parts of lactobacillus acidophilus bacterium powder, cheese breast
40 parts of bacillus bacterium powder, 40 parts of bifidobacterium lactis bacterium powder, 10 parts of vitamin C, 34 parts of FOS, 40 parts of skimmed milk power, malt paste
15 parts of 12 parts of essence, 12 parts of lactose and inulin, total viable count is 5 × 107cfu/g。
The preparation method of the probiotics medicine of above-mentioned treatment constipation, comprises the following steps：
A, strain is selected：Select Lactobacillus acidophilus species；
B, the production of hybrid seeds：Sterile environment is selected, strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium,
Then seal bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, sterilize：100 liters of fermentation tanks are subjected to empty elimination bacterium, culture medium is then placed in and is sterilized, 121 degrees Celsius of sterilising temp
More than, pressure inside the tank 0.12MPa, continue 20min sterilizings and terminate, temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure
Power is down to 0.01MPa；
D, it is inoculated with：The seed in incubator is put into desinfection chamber first and is sampled microscopy, growth selection it is good be inoculated with,
Turn on inoculation mouth closure, toward 100 liters of tanks in lead to micro filtrated air, ensure pressure inside the tank will not be zero, with inoculation flame ring
Inoculation mouth is placed on, after lighting flame ring, inoculation lid is opened completely, then triangular flask is placed on above flame ring, open three
Angle bottle, seed is poured into tank, tightens inoculation lid after terminating, filtrated air is led into tank, pressure inside the tank is stopped to 0.06MPa
Only, pressurize is carried out, temperature is kept for 37 DEG C, the MPa of pressure 0.06, and speed of agitator is adjusted to 60r/min, cultivates 12 hours；
E, culture transferring：Step b, the pipeline that the strain in 100 liters of fermentation tank then is passed through into sterilizing are carried out to 1000 liters of fermentation tanks
Moving in 1000 liters of fermentation tanks for preparing culture medium, temperature is kept for 37 DEG C, and the MPa of pressure 0.06, speed of agitator is adjusted to 60r/min,
Cultivate 12 hours, side viable count is sampled after growth well in 1000 liters of fermentation tanks；
F, centrifuge：Bacterium solution is turned clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed
After take out bacterium mud；
G, freeze：Bacterium mud is placed in the flaggy of freeze dryer, carries out lyophilized operation, -45 DEG C of freeze dryer rear lane temperature is taken out
Vacuum；
H, crush：Bacterium powder is obtained after crushing；
I, cheese-making lactobacillus bacterium powder and bifidobacterium lactis bacterium powder：By lactobacillus acidophilus, bifidobacterium lactis repeat step b to step
H, obtain Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium powder；
H, manufactured goods：By lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder, bifidobacterium lactis bacterium powder and vitamin C, oligomeric fruit
Sugar, skimmed milk power, maltodextrin, lactose and inulin are matched according to the drug weight and configured, and powder dress is made after well mixed
Bag.
Embodiment 3：
A kind of probiotics medicine for treating constipation, include the raw material of following weight proportion：25 parts of lactobacillus acidophilus bacterium powder, cheese breast
25 parts of bacillus bacterium powder, 25 parts of bifidobacterium lactis bacterium powder, 6 parts of vitamin C, 29 parts of FOS, 25 parts of skimmed milk power, malt paste
10 parts of 8 parts of essence, 8 parts of lactose and inulin, total viable count is 3 × 107cfu/g。
The preparation method of the probiotics medicine of above-mentioned treatment constipation, comprises the following steps：
A, strain is selected：Select Lactobacillus acidophilus species；
B, the production of hybrid seeds：Sterile environment is selected, strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium,
Then seal bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, sterilize：100 liters of fermentation tanks are subjected to empty elimination bacterium, culture medium is then placed in and is sterilized, 121 degrees Celsius of sterilising temp
More than, pressure inside the tank 0.12MPa, continue 20min sterilizings and terminate, temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure
Power is down to 0.01MPa；
D, it is inoculated with：The seed in incubator is put into desinfection chamber first and is sampled microscopy, growth selection it is good be inoculated with,
Turn on inoculation mouth closure, toward 100 liters of tanks in lead to micro filtrated air, ensure pressure inside the tank will not be zero, with inoculation flame ring
Inoculation mouth is placed on, after lighting flame ring, inoculation lid is opened completely, then triangular flask is placed on above flame ring, open three
Angle bottle, seed is poured into tank, tightens inoculation lid after terminating, filtrated air is led into tank, pressure inside the tank is stopped to 0.06MPa
Only, pressurize is carried out, temperature is kept for 37 DEG C, the MPa of pressure 0.06, and speed of agitator is adjusted to 60r/min, cultivates 12 hours；
E, culture transferring：Step b, the pipeline that the strain in 100 liters of fermentation tank then is passed through into sterilizing are carried out to 1000 liters of fermentation tanks
Moving in 1000 liters of fermentation tanks for preparing culture medium, temperature is kept for 37 DEG C, and the MPa of pressure 0.06, speed of agitator is adjusted to 60r/min,
Cultivate 12 hours, side viable count is sampled after growth well in 1000 liters of fermentation tanks；
F, centrifuge：Bacterium solution is turned clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed
After take out bacterium mud；
G, freeze：Bacterium mud is placed in the flaggy of freeze dryer, carries out lyophilized operation, -45 DEG C of freeze dryer rear lane temperature is taken out
Vacuum；
H, crush：Bacterium powder is obtained after crushing；
I, cheese-making lactobacillus bacterium powder and bifidobacterium lactis bacterium powder：By lactobacillus acidophilus, bifidobacterium lactis repeat step b to step
H, obtain Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium powder；
H, manufactured goods：By lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder, bifidobacterium lactis bacterium powder and vitamin C, oligomeric fruit
Sugar, skimmed milk power, maltodextrin, lactose and inulin are matched according to the drug weight and configured, and capsule is made i.e. after well mixed
Can.
Clinical case：
1st, Yang Lin, sex：Female, age：46 years old；Cause of disease symptom：Constipation, instructions of taking：Twice daily, once two grams, treatment knot
Fruit：Take capsule made from embodiment 1 after one day symptom be obviously improved, defecated once a day after taking three days；
2nd, Wang Lei, sex：Man, age：38 years old；Cause of disease symptom：Constipation, instructions of taking：Twice daily, once two grams, treatment knot
Fruit：Take capsule made from embodiment 3 after one day symptom be obviously improved, take and defecate two days later once a day；
3rd, CRBT rosy clouds, sex：Female, age：70 years old；Cause of disease symptom：Constipation, instructions of taking：Twice daily, once two grams, treatment
As a result：Take powderous preparations made from embodiment 2 after three days symptom be obviously improved, defecated once a day after taking five days.
Claims (2)
1. a kind of probiotics medicine for treating constipation, it is characterised in that include the raw material of following weight proportion：Lactobacillus acidophilus bacterium
Powder 10-40 parts, Lactobacillus casei bacterium powder 10-40 parts, bifidobacterium lactis bacterium powder 10-40 parts, vitamin C 1-10 parts, FOS
24-34 parts, skimmed milk power 10-40 parts, maltodextrin 2-12 parts, lactose 2-12 parts and inulin 5-15 parts, total viable count 1 ×
107More than cfu/g.
2. a kind of preparation method for the probiotics medicine for treating constipation, it is characterised in that comprise the following steps：
A, strain is selected：Select Lactobacillus acidophilus species；
B, the production of hybrid seeds：Sterile environment is selected, strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium,
Then seal bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, sterilize：100 liters of fermentation tanks are subjected to empty elimination bacterium, culture medium is then placed in and is sterilized, 121 degrees Celsius of sterilising temp
More than, pressure inside the tank 0.12MPa, continue 20min sterilizings and terminate, temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure
Power is down to 0.01MPa；
D, it is inoculated with：The seed in incubator is put into desinfection chamber first and is sampled microscopy, is inoculated with, turns on inoculation mouth sealing
Lid, toward 100 liters of tanks in be passed through micro filtrated air, guarantee pressure inside the tank will not be zero, and inoculation mouth is placed on inoculation flame ring,
After lighting flame ring, inoculation lid is opened completely, then triangular flask is placed on above flame ring, triangular flask is opened, seed is fallen
Enter in tank, tighten inoculation lid after terminating, filtrated air is led into tank, pressure inside the tank to 0.06MPa stops, and carries out pressurize, temperature
Degree is kept for 37 DEG C, the MPa of pressure 0.06, and speed of agitator is adjusted to 60r/min, is cultivated 12 hours；
E, culture transferring：Step b, the pipeline that the strain in 100 liters of fermentation tank then is passed through into sterilizing are carried out to 1000 liters of fermentation tanks
Moving in 1000 liters of fermentation tanks for preparing culture medium, temperature is kept for 37 DEG C, and the MPa of pressure 0.06, speed of agitator is adjusted to 60r/min,
Cultivate 12 hours, side viable count is sampled after growth well in 1000 liters of fermentation tanks；
F, centrifuge：Bacterium solution is turned clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed
After take out bacterium mud；
G, freeze：Bacterium mud is placed in the flaggy of freeze dryer, carries out lyophilized operation, -45 DEG C of freeze dryer rear lane temperature is taken out
Vacuum；
H, crush：Bacterium powder is obtained after crushing；
i：Cheese-making lactobacillus bacterium powder and bifidobacterium lactis bacterium powder：By lactobacillus acidophilus, bifidobacterium lactis repeat step b to step
H, obtain Lactobacillus casei bacterium powder and bifidobacterium lactis bacterium powder；
J, manufactured goods：By lactobacillus acidophilus bacterium powder, Lactobacillus casei bacterium powder, bifidobacterium lactis bacterium powder and vitamin C, oligomeric fruit
Sugar, skimmed milk power, maltodextrin, lactose and inulin are matched according to the drug weight and configured, be made after well mixed capsule or
Powder pack is made.
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| CN201710702266.4A CN107412274A (en) | 2017-08-16 | 2017-08-16 | A kind of probiotics medicine for treating constipation and preparation method thereof |
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| CN201710702266.4A CN107412274A (en) | 2017-08-16 | 2017-08-16 | A kind of probiotics medicine for treating constipation and preparation method thereof |
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ID=60436976
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108402371A (en) * | 2018-01-19 | 2018-08-17 | 广东润源中天生物科技有限公司 | A kind of prebiotic compositions that suitable person in middle and old age's constipation crowd takes |
| CN109260235A (en) * | 2018-10-23 | 2019-01-25 | 上海市第十人民医院 | A kind of application of composition in preparation prevention and treatment constipation drug or health care product |
| CN111567812A (en) * | 2020-05-12 | 2020-08-25 | 仙乐健康科技股份有限公司 | Food, health product or medicine for preventing, relieving or treating functional constipation of children |
| CN114831239A (en) * | 2022-06-17 | 2022-08-02 | 山西亿科宏泰生物科技有限公司 | Probiotic solid beverage capable of improving sleep and improving memory and preparation method thereof |
| CN116836848A (en) * | 2022-11-24 | 2023-10-03 | 宁波筑基培元生物科技有限公司 | Lactobacillus acidophilus capable of improving functional constipation and application thereof |
-
2017
- 2017-08-16 CN CN201710702266.4A patent/CN107412274A/en not_active Withdrawn
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108402371A (en) * | 2018-01-19 | 2018-08-17 | 广东润源中天生物科技有限公司 | A kind of prebiotic compositions that suitable person in middle and old age's constipation crowd takes |
| CN109260235A (en) * | 2018-10-23 | 2019-01-25 | 上海市第十人民医院 | A kind of application of composition in preparation prevention and treatment constipation drug or health care product |
| CN111567812A (en) * | 2020-05-12 | 2020-08-25 | 仙乐健康科技股份有限公司 | Food, health product or medicine for preventing, relieving or treating functional constipation of children |
| CN114831239A (en) * | 2022-06-17 | 2022-08-02 | 山西亿科宏泰生物科技有限公司 | Probiotic solid beverage capable of improving sleep and improving memory and preparation method thereof |
| CN116836848A (en) * | 2022-11-24 | 2023-10-03 | 宁波筑基培元生物科技有限公司 | Lactobacillus acidophilus capable of improving functional constipation and application thereof |
| CN116836848B (en) * | 2022-11-24 | 2024-03-01 | 宁波筑基培元生物科技有限公司 | Lactobacillus acidophilus capable of improving functional constipation and application thereof |
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Application publication date: 20171201 |