CN107441125A - A kind of hypoglycemic probiotics medicine and preparation method thereof - Google Patents

A kind of hypoglycemic probiotics medicine and preparation method thereof Download PDF

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CN107441125A
CN107441125A CN201710703782.9A CN201710703782A CN107441125A CN 107441125 A CN107441125 A CN 107441125A CN 201710703782 A CN201710703782 A CN 201710703782A CN 107441125 A CN107441125 A CN 107441125A
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bacterium powder
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王小伟
赵景阳
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Shanxi Ecross Hongtai Biotechnology Co Ltd
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Abstract

The invention belongs to drug field, and in particular to a kind of hypoglycemic probiotics medicine and preparation method thereof, include the raw material of following weight proportion：10 40 parts of lactobacillus plantarum bacterium powder, 10 40 parts of saccharomycete bacterium powder, 10 40 parts of clostridium butyricum bacterium powder, 10 40 parts of cheese lactic acid bacteria bacterium powder, 1 11 parts of vitamin C, 24 34 parts of FOS, 10 40 parts of skimmed milk power, 2 12 parts of maltodextrin, 2 12 parts of lactose, 5 15 parts of inulin, by probiotics bacterium powder and vitamin C, FOS and skimmed milk power, maltodextrin, lactose and inulin formulated in combination, prescription is rigorous, compatibility science, it is evident in efficacy, energy both symptoms and root causes, reaches rapidly and fundamentally the effect of hypoglycemic.

Description

A kind of hypoglycemic probiotics medicine and preparation method thereof
Technical field
The invention belongs to drug field, and in particular to a kind of hypoglycemic probiotics medicine and preparation method thereof.
Background technology
When blood glucose value higher than normal range (NR) is hyperglycaemia.Hyperglycaemia is also one high generally in everybody described " three high ". Fasting blood-glucose normal value in below 6.1mmol/L, the normal value of postprandial two hours blood glucose in below 7.8mmol/L, if above This scope, referred to as hyperglycaemia.Cause hyperglycaemia the cause of disease have it is following several：Pancreatic beta cell can not secrete enough insulin, α cells secrete glucagons are excessive；Insulin resistance be present including liver, muscle and adipose tissue in peripheral tissues；Enteron aisle is inhaled Receipts, gut flora and enteron aisle influence glycemic control hormone, cause its exception；Exceedingly resorption receives sugar to kidney；Nervous system is to sugar The dysregulation of metabolism；Medicine is mainly Chinese medicine, Western medicine, probiotics etc., but curative effect is respectively weak, and doctor trained in Western medicine can not be marked Originally simultaneous to control, side effect is obvious, and the traditional Chinese medical science course for the treatment of is longer, is extremely difficult to good result in a short time.Accordingly, it is capable to mitigate rapidly it is ailing and from Medicine that is fundamentally hypoglycemic and being free from side effects is clinical great difficult problem in the urgent need to address.
The content of the invention
In order to solve this problem, the present invention provides a kind of hypoglycemic probiotics medicine and preparation method thereof, will be prebiotic Bacterium bacterium powder and vitamin C, FOS and skimmed milk power, maltodextrin, lactose and inulin formulated in combination, prescription is rigorous, compatibility Science, it is evident in efficacy, energy both symptoms and root causes, reach rapidly and fundamentally the effect of hypoglycemic.
Technical scheme is used by order to solve its technical problem：
A kind of hypoglycemic probiotics medicine, include the raw material of following weight proportion：Lactobacillus plantarum bacterium powder 10-40 parts, ferment Female bacterium bacterium powder 10-40 parts, clostridium butyricum（Also known as Miyarisan, clostridium butyricum）Bacterium powder 10-40 parts, cheese lactic acid bacteria bacterium Powder 10-40 parts, vitamin C 1-11 parts, FOS 24-34 parts, skimmed milk power 10-40 parts, maltodextrin 2-12 parts, lactose 2- 12 parts, inulin 5-15 parts, total viable count is 1 × 107More than cfu/g.
The formulation of above-mentioned probiotics medicine is oral formulations.
The formulation of above-mentioned probiotics medicine is capsule or powder formulation.
The preparation method of above-mentioned hypoglycemic probiotics medicine, comprises the following steps：
A, strain is selected：Select lactobacillus plantarum strain；
B, the production of hybrid seeds：Sterile environment is selected, strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium, Then seal bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, sterilize：100 liters of fermentation tanks are subjected to empty elimination bacterium, culture medium is then placed in and is sterilized, 121 degrees Celsius of sterilising temp More than, pressure inside the tank 0.12MPa, continue 20min sterilizings and terminate, temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure Power is down to 0.01MPa；
D, it is inoculated with：The seed in incubator is put into desinfection chamber first and is sampled microscopy, is inoculated with, turns on inoculation mouth sealing Lid, toward 100 liters of tanks in be passed through micro filtrated air, guarantee pressure inside the tank will not be zero, and inoculation mouth is placed on inoculation flame ring, After lighting flame ring, inoculation lid is opened completely, then triangular flask is placed on above flame ring, triangular flask is opened, seed is fallen Enter in tank, tighten inoculation lid after terminating, filtrated air is led into tank, pressure inside the tank to 0.06MPa stops, and carries out pressurize, temperature Degree is kept for 37 DEG C, the MPa of pressure 0.06, and speed of agitator is adjusted to 60r/min, is cultivated 12 hours；
E, culture transferring：Step b, the pipeline that the strain in 100 liters of fermentation tank then is passed through into sterilizing are carried out to 1000 liters of fermentation tanks Moving in 1000 liters of fermentation tanks for preparing culture medium, temperature is kept for 37 DEG C, and the MPa of pressure 0.06, speed of agitator is adjusted to 60r/min, Cultivate 12 hours, side viable count is sampled after growth well in 1000 liters of fermentation tanks；
F, centrifuge：Bacterium solution is turned clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed After take out bacterium mud；
G, freeze：Bacterium mud is placed in the flaggy of freeze dryer, carries out lyophilized operation, -45 DEG C of freeze dryer rear lane temperature is taken out Vacuum；
H, crush：Bacterium powder is obtained after crushing；
I, saccharomycete bacterium powder processed, clostridium butyricum bacterium powder and cheese lactic acid bacteria bacterium powder：By saccharomycete and clostridium butyricum repeat step b extremely Step h, obtain saccharomycete bacterium powder, clostridium butyricum bacterium powder and cheese lactic acid bacteria bacterium powder；
J, manufactured goods：By lactobacillus plantarum bacterium powder, saccharomycete bacterium powder, clostridium butyricum bacterium powder, cheese lactic acid bacteria bacterium powder and Wei Sheng Plain C, FOS, skimmed milk power, maltodextrin, lactose and inulin are matched according to the drug weight and configured, after being well mixed Capsule is made or powder pack is made.
The effect of the various probiotics of the present invention is as follows：
Lactobacillus plantarum：The viable count of this bacterium is higher, can largely produce acid, and the acidic materials of output can degrade heavy metal. This bacterium has certain immunoregulation effect；There is inhibitory action to pathogenic bacteria；Reduce serum cholesterol content and prevention of cardiovascular disease Disease；Maintain intestinal flora balance；Promote absorption of nutrient ingredients；Alleviate lactose intolerance；Suppress formation of tumour cell etc.；
Saccharomycete：Containing substantial amounts of vitamin B1, vitamin B2 and niacin, the yeast after fermentation are a kind of very strong anti-oxidant Thing, liver can be protected, there is certain detoxication.The mineral energy such as selenium, chromium in yeast anti-aging, antitumor, prevention is dynamic Arteries and veins hardens, and improves the immunity of human body.After fermentation, a kind of phytic acid for influenceing the element absorptions such as calcium, magnesium, iron can be divided in flour Solution, so as to improve absorption and utilization of the human body to these nutriments；
Clostridium butyricum:Also known as Miyarisan, clostridium butyricum：The short chain fatty acids such as butyric acid can be produced, are gut epitheliums The Major Nutrient material of histiocytic regeneration and reparation, repairs impaired intestinal mucosa, and promotes the production of beneficial bacterium in enteron aisle, Suppress beneficial bacterium breeding；
Cheese lactic acid bacteria：Strengthen nonspecific resistance of the host to microbial pathogens, accelerate to remove intestinal pathogens, control Enteric flora disturbance and enhancing enteron aisle permeability are treated, regulation intestinal flora balance is played, promotes human consumption to absorb；
The beneficial effects of the invention are as follows：The present invention both may be used compared with the existing simple Chinese medicine of in the market, Western medicine and probiotics Inherently improve human body constitution to nurse one's health enteron aisle, can adjust rapidly again disorder intestinal microecology system, directly reparation by The intestinal mucosa of damage, intestinal immunity is improved, treats both principal and secondary aspect of disease, liver can also be protected, fundamentally play the effect of hypoglycemic.
Embodiment
Embodiment 1：
A kind of hypoglycemic probiotics medicine, include the raw material of following weight proportion：10 parts of lactobacillus plantarum bacterium powder, saccharomycete 10 parts of bacterium powder, 10 parts of clostridium butyricum bacterium powder, 10 parts of cheese lactic acid bacteria bacterium powder, 1 part of vitamin C, 24 parts of glucose, skimmed milk power 10 Part, 2 parts of maltodextrin, 2 parts of lactose, 5 parts of inulin, total viable count is 2 × 107cfu/g。
The preparation method of above-mentioned hypoglycemic probiotics medicine, comprises the following steps：
A, strain is selected：Select lactobacillus plantarum strain；
B, the production of hybrid seeds：Sterile environment is selected, strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium, Then seal bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, sterilize：100 liters of fermentation tanks are subjected to empty elimination bacterium, culture medium is then placed in and is sterilized, 121 degrees Celsius of sterilising temp More than, pressure inside the tank 0.12MPa, continue 20min sterilizings and terminate, temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure Power is down to 0.01MPa；
D, it is inoculated with：The seed in incubator is put into desinfection chamber first and is sampled microscopy, is inoculated with, turns on inoculation mouth sealing Lid, toward 100 liters of tanks in be passed through micro filtrated air, guarantee pressure inside the tank will not be zero, and inoculation mouth is placed on inoculation flame ring, After lighting flame ring, inoculation lid is opened completely, then triangular flask is placed on above flame ring, triangular flask is opened, seed is fallen Enter in tank, tighten inoculation lid after terminating, filtrated air is led into tank, pressure inside the tank to 0.06MPa stops, and carries out pressurize, temperature Degree is kept for 37 DEG C, the MPa of pressure 0.06, and speed of agitator is adjusted to 60r/min, is cultivated 12 hours；
E, culture transferring：Step b, the pipeline that the strain in 100 liters of fermentation tank then is passed through into sterilizing are carried out to 1000 liters of fermentation tanks Moving in 1000 liters of fermentation tanks for preparing culture medium, temperature is kept for 37 DEG C, and the MPa of pressure 0.06, speed of agitator is adjusted to 60r/min, Cultivate 12 hours, side viable count is sampled after growth well in 1000 liters of fermentation tanks；
F, centrifuge：Bacterium solution is turned clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed After take out bacterium mud；
G, freeze：Bacterium mud is placed in the flaggy of freeze dryer, carries out lyophilized operation, -45 DEG C of freeze dryer rear lane temperature is taken out Vacuum；
H, crush：Bacterium powder is obtained after crushing；
I, saccharomycete bacterium powder processed, clostridium butyricum bacterium powder and cheese lactic acid bacteria bacterium powder：By saccharomycete and clostridium butyricum repeat step b extremely Step h, obtain saccharomycete bacterium powder, clostridium butyricum bacterium powder and cheese lactic acid bacteria bacterium powder；
J, manufactured goods：By lactobacillus plantarum bacterium powder, saccharomycete bacterium powder, clostridium butyricum bacterium powder, cheese lactic acid bacteria bacterium powder and Wei Sheng Plain C, FOS, skimmed milk power, maltodextrin, lactose and inulin are matched according to the drug weight and configured, after being well mixed Capsule is made.
Embodiment 2：
1st, a kind of hypoglycemic probiotics medicine, the raw material of following weight proportion is included：40 parts of lactobacillus plantarum bacterium powder, yeast 40 parts of bacterium bacterium powder, 40 parts of clostridium butyricum bacterium powder, 40 parts of cheese lactic acid bacteria bacterium powder, 11 parts of vitamin C, 34 parts of FOS, degreasing 40 parts of milk powder, 12 parts of maltodextrin, 12 parts of lactose, 15 parts of inulin, total viable count is 5 × 107cfu/g。
The preparation method of above-mentioned hypoglycemic probiotics medicine, comprises the following steps：
A, strain is selected：Select lactobacillus plantarum strain；
B, the production of hybrid seeds：Sterile environment is selected, strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium, Then seal bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, sterilize：100 liters of fermentation tanks are subjected to empty elimination bacterium, culture medium is then placed in and is sterilized, 121 degrees Celsius of sterilising temp More than, pressure inside the tank 0.12MPa, continue 20min sterilizings and terminate, temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure Power is down to 0.01MPa；
D, it is inoculated with：The seed in incubator is put into desinfection chamber first and is sampled microscopy, is inoculated with, turns on inoculation mouth sealing Lid, toward 100 liters of tanks in be passed through micro filtrated air, guarantee pressure inside the tank will not be zero, and inoculation mouth is placed on inoculation flame ring, After lighting flame ring, inoculation lid is opened completely, then triangular flask is placed on above flame ring, triangular flask is opened, seed is fallen Enter in tank, tighten inoculation lid after terminating, filtrated air is led into tank, pressure inside the tank to 0.06MPa stops, and carries out pressurize, temperature Degree is kept for 37 DEG C, the MPa of pressure 0.06, and speed of agitator is adjusted to 60r/min, is cultivated 12 hours；
E, culture transferring：Step b, the pipeline that the strain in 100 liters of fermentation tank then is passed through into sterilizing are carried out to 1000 liters of fermentation tanks Moving in 1000 liters of fermentation tanks for preparing culture medium, temperature is kept for 37 DEG C, and the MPa of pressure 0.06, speed of agitator is adjusted to 60r/min, Cultivate 12 hours, side viable count is sampled after growth well in 1000 liters of fermentation tanks；
F, centrifuge：Bacterium solution is turned clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed After take out bacterium mud；
G, freeze：Bacterium mud is placed in the flaggy of freeze dryer, carries out lyophilized operation, -45 DEG C of freeze dryer rear lane temperature is taken out Vacuum；
H, crush：Bacterium powder is obtained after crushing；
I, saccharomycete bacterium powder processed, clostridium butyricum bacterium powder and cheese lactic acid bacteria bacterium powder：By saccharomycete and clostridium butyricum repeat step b extremely Step h, obtain saccharomycete bacterium powder, clostridium butyricum bacterium powder and cheese lactic acid bacteria bacterium powder；
J, manufactured goods：By lactobacillus plantarum bacterium powder, saccharomycete bacterium powder, clostridium butyricum bacterium powder, cheese lactic acid bacteria bacterium powder and Wei Sheng Plain C, FOS, skimmed milk power, maltodextrin, lactose and inulin are matched according to the drug weight and configured, after being well mixed Powder pack is made.
Embodiment 3：
1st, a kind of hypoglycemic probiotics medicine, the raw material of following weight proportion is included：25 parts of lactobacillus plantarum bacterium powder, yeast 25 parts of bacterium bacterium powder, 25 parts of clostridium butyricum bacterium powder, 25 parts of cheese lactic acid bacteria bacterium powder, 6 parts of vitamin C, 29 parts of FOS, defatted milk 25 parts of powder, 7 parts of maltodextrin, 7 parts of lactose, 10 parts of inulin, total viable count is 3 × 107cfu/g。
The preparation method of above-mentioned hypoglycemic probiotics medicine, comprises the following steps：
A, strain is selected：Select lactobacillus plantarum strain；
B, the production of hybrid seeds：Sterile environment is selected, strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium, Then seal bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, sterilize：100 liters of fermentation tanks are subjected to empty elimination bacterium, culture medium is then placed in and is sterilized, 121 degrees Celsius of sterilising temp More than, pressure inside the tank 0.12MPa, continue 20min sterilizings and terminate, temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure Power is down to 0.01MPa；
D, it is inoculated with：The seed in incubator is put into desinfection chamber first and is sampled microscopy, is inoculated with, turns on inoculation mouth sealing Lid, toward 100 liters of tanks in be passed through micro filtrated air, guarantee pressure inside the tank will not be zero, and inoculation mouth is placed on inoculation flame ring, After lighting flame ring, inoculation lid is opened completely, then triangular flask is placed on above flame ring, triangular flask is opened, seed is fallen Enter in tank, tighten inoculation lid after terminating, filtrated air is led into tank, pressure inside the tank to 0.06MPa stops, and carries out pressurize, temperature Degree is kept for 37 DEG C, the MPa of pressure 0.06, and speed of agitator is adjusted to 60r/min, is cultivated 12 hours；
E, culture transferring：Step b, the pipeline that the strain in 100 liters of fermentation tank then is passed through into sterilizing are carried out to 1000 liters of fermentation tanks Moving in 1000 liters of fermentation tanks for preparing culture medium, temperature is kept for 37 DEG C, and the MPa of pressure 0.06, speed of agitator is adjusted to 60r/min, Cultivate 12 hours, side viable count is sampled after growth well in 1000 liters of fermentation tanks；
F, centrifuge：Bacterium solution is turned clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed After take out bacterium mud；
G, freeze：Bacterium mud is placed in the flaggy of freeze dryer, carries out lyophilized operation, -45 DEG C of freeze dryer rear lane temperature is taken out Vacuum；
H, crush：Bacterium powder is obtained after crushing；
I, saccharomycete bacterium powder processed, clostridium butyricum bacterium powder and cheese lactic acid bacteria bacterium powder：By saccharomycete and clostridium butyricum repeat step b extremely Step h, obtain saccharomycete bacterium powder, clostridium butyricum bacterium powder and cheese lactic acid bacteria bacterium powder；
J, manufactured goods：By lactobacillus plantarum bacterium powder, saccharomycete bacterium powder, clostridium butyricum bacterium powder, cheese lactic acid bacteria bacterium powder and Wei Sheng Plain C, FOS, skimmed milk power, maltodextrin, lactose and inulin are matched according to the drug weight and configured, after being well mixed Capsule is made.
Clinical case：
Case 1：Continued powder lotus, sex：Female, age：61 years old；Cause of disease symptom：Blood glucose（On an empty stomach）8.5, instructions of taking：Twice daily, Once two grams, treatment results：Take capsule made from embodiment 3 after seven days blood glucose be obviously improved, blood glucose（On an empty stomach）6.1；
Case 2：Ma Guonv, sex：Female, age：64 years old；Cause of disease symptom：Blood glucose（On an empty stomach）13, instructions of taking：Twice daily, one Secondary two grams, treatment results：Take powder preparation made from embodiment 2 after seven days blood glucose be obviously improved, blood glucose（On an empty stomach）7.0；
Case 3：Continue silver-colored fruit, sex：Female, age：52 years old；Cause of disease symptom：Blood glucose（On an empty stomach）20, instructions of taking：Twice daily, one Secondary two grams, treatment results：Take capsule made from embodiment 1 after seven days blood glucose be obviously improved, blood glucose（On an empty stomach）12.

Claims (2)

1. a kind of hypoglycemic probiotics medicine, it is characterised in that include the raw material of following weight proportion：Lactobacillus plantarum bacterium Powder 10-40 parts, saccharomycete bacterium powder 10-40 parts, clostridium butyricum bacterium powder 10-40 parts, cheese lactic acid bacteria bacterium powder 10-40 parts, vitamin C1-11 parts, FOS 24-34 parts, skimmed milk power 10-40 parts, maltodextrin 2-12 parts, lactose 2-12 parts, inulin 5-15 parts, Total viable count is 1 × 107More than cfu/g.
2. a kind of preparation method of hypoglycemic probiotics medicine, it is characterised in that comprise the following steps：
A, strain is selected：Select lactobacillus plantarum strain；
B, the production of hybrid seeds：Sterile environment is selected, strain transfer needle is taken out and is put into 500 milliliters of triangular flasks equipped with culture medium, Then seal bottleneck to be put into incubator, 37 DEG C of the temperature of incubator, static gas wave refrigerator 12 hours；
C, sterilize：100 liters of fermentation tanks are subjected to empty elimination bacterium, culture medium is then placed in and is sterilized, 121 degrees Celsius of sterilising temp More than, pressure inside the tank 0.12MPa, continue 20min sterilizings and terminate, temperature in tank is then down to 37 DEG C with cooling water, tank internal pressure Power is down to 0.01MPa；
D, it is inoculated with：The seed in incubator is put into desinfection chamber first and is sampled microscopy, is inoculated with, turns on inoculation mouth sealing Lid, toward 100 liters of tanks in be passed through micro filtrated air, guarantee pressure inside the tank will not be zero, and inoculation mouth is placed on inoculation flame ring, After lighting flame ring, inoculation lid is opened completely, then triangular flask is placed on above flame ring, triangular flask is opened, seed is fallen Enter in tank, tighten inoculation lid after terminating, filtrated air is led into tank, pressure inside the tank to 0.06MPa stops, and carries out pressurize, temperature Degree is kept for 37 DEG C, the MPa of pressure 0.06, and speed of agitator is adjusted to 60r/min, is cultivated 12 hours；
E, culture transferring：Step b, the pipeline that the strain in 100 liters of fermentation tank then is passed through into sterilizing are carried out to 1000 liters of fermentation tanks Moving in 1000 liters of fermentation tanks for preparing culture medium, temperature is kept for 37 DEG C, and the MPa of pressure 0.06, speed of agitator is adjusted to 60r/min, Cultivate 12 hours, side viable count is sampled after growth well in 1000 liters of fermentation tanks；
F, centrifuge：Bacterium solution is turned clockwise by centrifuge, centrifuge speed for 16000r/min, carries out bacterium solution separation, is completed After take out bacterium mud；
G, freeze：Bacterium mud is placed in the flaggy of freeze dryer, carries out lyophilized operation, -45 DEG C of freeze dryer rear lane temperature is taken out Vacuum；
H, crush：Bacterium powder is obtained after crushing；
I, saccharomycete bacterium powder processed, clostridium butyricum bacterium powder and cheese lactic acid bacteria bacterium powder：By saccharomycete and clostridium butyricum repeat step b extremely Step h, obtain saccharomycete bacterium powder, clostridium butyricum bacterium powder and cheese lactic acid bacteria bacterium powder；
J, manufactured goods：By lactobacillus plantarum bacterium powder, saccharomycete bacterium powder, clostridium butyricum bacterium powder, cheese lactic acid bacteria bacterium powder and Wei Sheng Plain C, FOS, skimmed milk power, maltodextrin, lactose and inulin are matched according to the drug weight and configured, after being well mixed Capsule is made or powder pack is made.
CN201710703782.9A 2017-08-16 2017-08-16 A kind of hypoglycemic probiotics medicine and preparation method thereof Pending CN107441125A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108741084A (en) * 2018-05-18 2018-11-06 珠海中食月太健康科技有限公司 A kind of product improving enteron aisle defaecation
CN110638841A (en) * 2019-09-25 2020-01-03 山东艾克韦生物技术有限公司 Probiotics and prebiotics compound preparation, preparation method and application thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108741084A (en) * 2018-05-18 2018-11-06 珠海中食月太健康科技有限公司 A kind of product improving enteron aisle defaecation
CN110638841A (en) * 2019-09-25 2020-01-03 山东艾克韦生物技术有限公司 Probiotics and prebiotics compound preparation, preparation method and application thereof
CN110638841B (en) * 2019-09-25 2024-02-20 山东艾克韦生物技术有限公司 Probiotics and prebiotics composite preparation, preparation method and application thereof

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Application publication date: 20171208