CN109503462B - 托法替布中间体(3r,4r)-n,4-二甲基-1-苄基-3-哌啶胺的合成方法 - Google Patents
托法替布中间体(3r,4r)-n,4-二甲基-1-苄基-3-哌啶胺的合成方法 Download PDFInfo
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- CN109503462B CN109503462B CN201910052492.1A CN201910052492A CN109503462B CN 109503462 B CN109503462 B CN 109503462B CN 201910052492 A CN201910052492 A CN 201910052492A CN 109503462 B CN109503462 B CN 109503462B
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
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- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
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CN201910052492.1A CN109503462B (zh) | 2019-01-21 | 2019-01-21 | 托法替布中间体(3r,4r)-n,4-二甲基-1-苄基-3-哌啶胺的合成方法 |
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CN201910052492.1A CN109503462B (zh) | 2019-01-21 | 2019-01-21 | 托法替布中间体(3r,4r)-n,4-二甲基-1-苄基-3-哌啶胺的合成方法 |
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CN109503462A CN109503462A (zh) | 2019-03-22 |
CN109503462B true CN109503462B (zh) | 2022-03-25 |
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Families Citing this family (5)
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CN111606827B (zh) * | 2020-06-23 | 2022-10-25 | 内蒙古京东药业有限公司 | 一种制备依度沙班手性胺中间体的方法 |
CN111848496B (zh) * | 2020-07-28 | 2021-10-08 | 湖南华纳大药厂手性药物有限公司 | 一种托法替布中间体胺及其双盐酸盐的制备方法 |
CN112250615A (zh) * | 2020-09-14 | 2021-01-22 | 甘肃皓天医药科技有限责任公司 | 一种托法替尼中间体顺式-1-苄基-n,4-二甲基哌啶-3-胺二盐酸盐的制备方法 |
CN114835631B (zh) * | 2021-02-01 | 2024-02-13 | 重庆恩联生物科技有限公司 | 顺式-1-苄基-4-甲基-3-甲氨基-哌啶双盐酸盐的制备方法 |
CN115073358B (zh) * | 2022-07-21 | 2023-09-26 | 安徽德诺医药股份有限公司 | 一种n-苄基-4-哌啶甲酸乙酯的制备方法 |
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CN1305849C (zh) * | 2004-12-29 | 2007-03-21 | 江苏正大天晴药业股份有限公司 | 3-甲氨基哌啶及其盐的制备方法 |
KR100987870B1 (ko) * | 2005-07-29 | 2010-10-13 | 화이자 프로덕츠 인코포레이티드 | 피롤로[2,3-d]피리미딘 유도체, 이들의 중간체 및 합성 |
CN103113290B (zh) * | 2012-12-18 | 2015-06-03 | 浙江普洛康裕制药有限公司 | 一种巴洛沙星中间体的制备方法 |
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Denomination of invention: Synthesis of intermediate (3R, 4R) - N, 4-dimethyl-1-benzyl-3-piperidine amine of tofatib Effective date of registration: 20220627 Granted publication date: 20220325 Pledgee: Bank of China Limited Ulanqab branch Pledgor: INNER MONGOLIA JINGDONG PHARMACEUTICAL Co.,Ltd. Registration number: Y2022150000057 |
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Date of cancellation: 20230822 Granted publication date: 20220325 Pledgee: Bank of China Limited Ulanqab branch Pledgor: INNER MONGOLIA JINGDONG PHARMACEUTICAL Co.,Ltd. Registration number: Y2022150000057 |