CN109498782A - It is a kind of to treat dermopathic Chinese medicine and preparation method thereof - Google Patents

It is a kind of to treat dermopathic Chinese medicine and preparation method thereof Download PDF

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CN109498782A
CN109498782A CN201811410340.6A CN201811410340A CN109498782A CN 109498782 A CN109498782 A CN 109498782A CN 201811410340 A CN201811410340 A CN 201811410340A CN 109498782 A CN109498782 A CN 109498782A
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chinese medicine
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嘉肖雄
嘉海波
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Abstract

The present invention relates to technical field of traditional Chinese medicine preparation, specifically disclose and a kind of treat dermopathic Chinese medicine composition and preparation method thereof;Including raw material are as follows: frutus cnidii, kuh-seng, the root of Dahurain angelica, cortex cinnamomi, dark plum and hawthorn, Radix Astragali, rheum officinale, ginger, pericarpium zanthoxyli, Chinese prickly ash, radix rehmanniae preparata, mature vinegar, borneol, betel nut, peach kernel, safflower, Chinese blister beetle;The present invention is according to Traditional Chinese medical theory, pass through scientific compatibility, and the experiment through many years is groped obtained from exploitation, its not only have Runzao Zhiyang, play the role of sterilization it is anti-inflammatory, and it also has improvement skin speciality, skin disease is treated on the whole, prevents and treats dermopathic recurrence, is mainly used for the treatment and prevention of psoriasis, eczema, dermatitis, shingles zoster epifolliculitis, acne, the ringworm of the foot.

Description

It is a kind of to treat dermopathic Chinese medicine and preparation method thereof
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to a kind of to treat dermopathic Chinese medicine composition and its preparation Method.
Background technique
Skin disease is the general name occurred in skin and skin accessory organ's disease.Skin is the maximum organ of human body, skin The type of disease is not only various, and the disease that a variety of internal organ occur can also have performance on the skin.Cause dermopathic reason very much, Such as skin disease caused by infective agent, such as leprosy, scabies, nosomycosis, bacterial skin infections usually have certain infectiousness, Health is not only influenced, and is raised fear and social discrimination, but with the improvement of people ' s living standards and science and technology Progress, the infectious diseases such as leprosy have been obviously controlled in the whole world.Other cause dermopathic interior external factor, such as mechanical Property, it is physical, chemically, biological, incretion, immunity etc., be increasingly valued by people at present.
Currently, containing in these drugs big for treating compound medicine of the dermopathic medicine based on western medicine composition in the market Hormone is measured, though healing can be rapidly achieved, but it is usually palliative, it is difficult to dermopathic recurrence is controlled, And drug of the long-time service containing hormone can generate biggish side effect.
Summary of the invention
The present invention overcomes the shortcomings of the prior art, provides and a kind of treats dermopathic Chinese medicine and preparation method thereof.It should Chinese medicine composition not only has good treatment skin disease effect, and has no toxic and side effect to human body.It is mainly used for treating and preventing Psoriasis, eczema, dermatitis, shingles zoster epifolliculitis, acne, the such fungal infection of the ringworm of the foot and the skin due to caused by mental disease Disease.
The present invention is achieved through the following technical solutions.
It is a kind of to treat dermopathic Chinese medicine, the raw material including following parts by weight: frutus cnidii: 25-35 parts, kuh-seng: 25-35 Part, the root of Dahurain angelica: 25-35 parts, cortex cinnamomi: 25-35 parts, dark plum: 25-35 parts, hawthorn: 25-35 parts, Radix Astragali: 25-35 parts, rheum officinale: 25- 35 parts, ginger: 35-45 parts, pericarpium zanthoxyli: 5-10 parts, Chinese prickly ash: 25-35 parts, radix rehmanniae preparata: 25-35 parts, mature vinegar: 450-500 parts, ice Piece: 5-10 parts, betel nut: 25-35 parts, peach kernel: 45-55 parts, safflower: 45-55 parts, Chinese blister beetle: 20-30 parts.
Preferably, the mature vinegar is rice vinegar.
Preferably, the mature vinegar can be replaced by brewing white spirit, and used parts by weight are identical.
A kind of preparation method for treating dermopathic Chinese medicine, comprising the following steps:
By frutus cnidii, kuh-seng, the root of Dahurain angelica, cortex cinnamomi, dark plum, hawthorn, Radix Astragali, rheum officinale, ginger, pericarpium zanthoxyli, Chinese prickly ash, radix rehmanniae preparata, betel nut, peach kernel It is put into mature vinegar with safflower, sealed soak 7-9 days, after the 15-20min of small fire tanning later, moderate heat is endured after sealing is placed 1 day 30-40min processed;Borneol is added after being cooled to room temperature and removes the Chinese blister beetle on head and wing portion, takes filter after filtering after sealing 7-8 days Liquid obtains the Chinese medicine.
Further, the filtrate is brewed into lotion and obtains the Chinese medicine.
Further, the mature vinegar can be substituted by brewing white spirit, and used parts by weight are identical, and the brew is white Alcoholic strength >=50 ° of wine.
Respectively main effect has used ingredient:
The frutus cnidii: antibacterial anti-inflammatory, antipruritic, expelling parasite, antiallergy.
The kuh-seng: heat-clearing solution is dry, desinsection is antipruritic.
The root of Dahurain angelica: wind-damp dispelling, promoting blood circulation toxin expelling, myogenic pain relieving.
The cortex cinnamomi: sedation and analgesia, antibacterial, degrading the channel.
The dark plum: pruitus, expelling parasite.
The hawthorn: activating microcirculation and removing stasis medicinal.
The radix scutellariae: heat-clearing and damp-drying drug, purging fire for removing toxin.
The rheum officinale: removing dampness through diuresis and removing jaundice, removing toxicity for eliminating carbuncles.
The ginger: promoting blood circulation dispelling cold.
The pericarpium zanthoxyli: warm in pain, dispelling cold and removing dampness, desinsection.
The Chinese prickly ash: antibacterial cold dispelling.
The mature vinegar is also grieved wine: moisturizing, antibacterial, desinsection carbuncle that disappears dissipating bind.
The radix rehmanniae preparata: it enriches blood.
The borneol: accelerate metabolic, clearing heat and detoxicating, antipruritic.
The betel nut: expelling parasite, disappear it is too fat to move.
The Chinese blister beetle: malicious phagedenoma, powder medicine (Zhuyusan) knot are attacked.
The peach kernel: activating microcirculation and removing stasis medicinal.
The safflower: activating microcirculation and removing stasis medicinal, removing pattogenic heat from the blood and toxic material from the body.
The present invention is generated compared with the existing technology to be had the beneficial effect that.
The present invention be according to Traditional Chinese medical theory, by scientific compatibility, and obtained from exploitation is groped in the experiment through many years, Its not only have Runzao Zhiyang, play the role of sterilization it is anti-inflammatory, and its also have improve skin speciality, treat skin disease on the whole, For having as fungal infection or because of psoriasis caused by mental disease, eczema, dermatitis, shingles zoster epifolliculitis, acne, the ringworm of the foot Feature significant in efficacy prevents and treats dermopathic recurrence.
Specific embodiment
In order to which technical problems, technical solutions and advantages to be solved are more clearly understood, in conjunction with reality Example is applied, the present invention will be described in further detail.It should be appreciated that specific embodiment described herein is only used to explain this Invention, is not intended to limit the present invention.Below with reference to the embodiment technical solution that the present invention will be described in detail, but protection scope not by This limitation.
Embodiment 1
It is a kind of to treat dermopathic Chinese medicine, it is made of following raw material: frutus cnidii: 25g, kuh-seng: 30g, the root of Dahurain angelica: 35g, cortex cinnamomi: 25g, dark plum: 35g, hawthorn: 27g, Radix Astragali: 28g, rheum officinale: 25g, ginger: 45g, pericarpium zanthoxyli: 8g, Chinese prickly ash: 30 g, radix rehmanniae preparata: 25g, Mature vinegar: 500g, borneol: 10g, betel nut: 25g, peach kernel: 50g, safflower: 45g, Chinese blister beetle: 20g;
A kind of preparation method for treating dermopathic Chinese medicine: by frutus cnidii, kuh-seng, the root of Dahurain angelica, cortex cinnamomi, dark plum, hawthorn, Radix Astragali, greatly Huang, ginger, pericarpium zanthoxyli, Chinese prickly ash, radix rehmanniae preparata, betel nut, peach kernel and safflower are put into mature vinegar, and sealed soak 7 days, small fire boiled later After 15min, moderate heat boils 30min after sealing is placed 1 day;Borneol is added after being cooled to room temperature and removes the spot on head and wing portion Chinese blister beetle takes filtrate to obtain the Chinese medicine after filtering after sealing 7 days.
Embodiment 2
It is a kind of to treat dermopathic Chinese medicine, it is made of following raw material: frutus cnidii: 35g, kuh-seng: 35g, the root of Dahurain angelica: 25g, cortex cinnamomi: 30g, dark plum: 25g, hawthorn: 30g, Radix Astragali: 35g, rheum officinale: 30g, ginger: 35g, pericarpium zanthoxyli: 5g, Chinese prickly ash: 25g, radix rehmanniae preparata: 35g, 50 ° of brewing spirits: 500g, borneol: 5g, betel nut: 35g, peach kernel: 45g, safflower: 50g, Chinese blister beetle: 30g;
A kind of preparation method for treating dermopathic Chinese medicine: by frutus cnidii, kuh-seng, the root of Dahurain angelica, cortex cinnamomi, dark plum, hawthorn, Radix Astragali, greatly Huang, ginger, pericarpium zanthoxyli, Chinese prickly ash, radix rehmanniae preparata, betel nut, peach kernel and safflower are put into mature vinegar, and sealed soak 9 days, small fire boiled later After 20min, moderate heat boils 40min after sealing is placed 1 day;Borneol is added after being cooled to room temperature and removes the spot on head and wing portion Chinese blister beetle takes filtrate to obtain the Chinese medicine after filtering after sealing 8 days.
Embodiment 3
It is a kind of to treat dermopathic Chinese medicine, it is made of following raw material: frutus cnidii: 30g, kuh-seng: 25g, the root of Dahurain angelica: 30g, cortex cinnamomi: 35g, dark plum: 30g, hawthorn: 35g, Radix Astragali: 25g, rheum officinale: 35g, ginger: 40g, pericarpium zanthoxyli: 10g, Chinese prickly ash: 35g, radix rehmanniae preparata: 30g, Mature vinegar: 500g, borneol: 8g, betel nut: 30g, peach kernel: 55g, safflower: 55g, Chinese blister beetle: 25g;
A kind of preparation method for treating dermopathic Chinese medicine: by frutus cnidii, kuh-seng, the root of Dahurain angelica, cortex cinnamomi, dark plum, hawthorn, Radix Astragali, greatly Huang, ginger, pericarpium zanthoxyli, Chinese prickly ash, radix rehmanniae preparata, betel nut, peach kernel and safflower are put into mature vinegar, and sealed soak 8 days, small fire boiled later After 15min, moderate heat boils 40min after sealing is placed 1 day;Borneol is added after being cooled to room temperature and removes the spot on head and wing portion Chinese blister beetle takes filtrate to obtain the Chinese medicine after filtering after sealing 7 days.
Clinical example 4
Guo, male, 36 years old, lives Yuncheng Yanhu District salt lake city cell, takes office in Yuncheng Yanhu District airport administration committee, Consultation time, 2013.2.15.
Main suit: head decortication, tumour play sore in aubergine all over the face, and surprise itches unbearably 4 years as long as, successively goes to a doctor in Beijing 301 Hospital, BJ Union Hospital, Beijing China cure Hospital of Skin Diseases, Taiyuan Hospital of Skin Diseases, and Xi'an Xijing hospital etc. is diagnosed as hair follicle Scorching unsatisfactory curative effect always.Using this reagent, 2 antipruritic, and swollen disappearance on the one or seven is fully recovered on the 20th.It has not relapsed so far.
Clinical example 5
Liu, male, 48 years old, lives Yuncheng Yanhu District Liberation Road foreign trade family dependents' building, main suit: at the beginning of 2010, whenever rainy day And winter, scalp increase, surprise is itched unbearably scratch brokenly after form a scab, illness 6 years as long as, Yuncheng central hospital of once going to a doctor, in Yuncheng Hospital, Xi'an Xijing hospital, is diagnosed as fungal infection, is mainly treated using Da Kening, using mitigating immediately, deactivates immediately Recurrence.Medication in 2016 one day antipruritic, fully recovers within 7th, has not relapsed so far.
Clinical example 6
Yang, male, 47 years old, Henan Province, the Lingshan, Luoshan County town head people from mountain village broke left leg because well lid falls off, by phalanx, because Hot weather, suppurative infection are hospitalized 20 days in Yuncheng central hospital and do not feel any better.Medication is treated, and is drawn out the pus within 3rd, and 15 days Recovery from illness, has not relapsed so far.
Clinical example 7
Sun, male, 62 years old, main suit: suffering from back eczema, four acrodermatitis for 2016, and surprise is itched unbearably, and illness is sought medical advice everywhere more than a year In vain, carry out here medical treatment after being introduced, 2 antipruritic, and symptom mitigated on 7th, fully recovers within 18th.
Clinical example 8
So-and-so is closed, male 54 years old, lives the garden Yuncheng Chun Mu, main suit: since operating pressure is excessive, suffering from psoriasis (psoriasis) 33 As long as year, the skin of whole body 70 or more percent is all region of disease, can be described with black and blue, and surprise is itched unbearably, is gone around complete State's various big hospital attempted various treatments, including medicine of taking poison, and ate scorpion, poisonous snake treatment was eaten, without positive effect.In patient to It extremely feels oneself inferior, extremely deleterious effect is caused to life and work, it is overwhelmed with sorrow.The drug for taking the embodiment of the present invention 1 afterwards is controlled It treats, 7 antipruritic, and silver bits were reduced on 13rd, and skin had not been swollen on 16th, fully recovers within 35th.
Clinical example 9
It is honest and clean certain, male 27 years old, lives Yuncheng clock tower cell, main suit: patient due in 13 years old that year of man into thief, it is big frightened, lead Psoriasis (psoriasis) systemic sites are caused, various Chinese and Western hospitals check, take medicine, treating, again and again, do not cure thoroughly.Afterwards The drug therapy of the embodiment of the present invention 3 is taken, the colour of skin recovered immediately normally on 13rd, was no different with normal skin.It has not relapsed so far.
Embodiment 10: clinical trial
Selection patients with acne, eczema patients, psoriatic, dermatitis patients, each 15 people of ringworm of the foot patient, average age 40.2 years old, Wherein male 45 people, 30 people of female.
Embodiment 11: fungal infectious dermatitis animal pattern experiment
1) prepared by animal model:
60 SD rats, half male and half female, 200 ± 20g of weight.Read in 100 μ L/200g white of rat auris dextra auricle intracutaneous injection Pearl bacterium bacterium solution constructs rat auricle fungal infectious dermatitis model.Inoculation Candida albicans the 3rd day, it is random from each group rat 1 is extracted, auricle edema position is taken to apply ware, Anaerobic culturel 48h, it was demonstrated that is candida albicans infection.3 are randomly divided into after modeling Group, i.e. model group, treatment group and control group.
2) experimental method:
Blank control group does not give any processing, smears physiological saline 2 times daily;After modeling, model group smears physiology salt daily Water 2 times, invention formulation 2 times of embodiment 1- embodiment 3, each 0.2g are smeared daily by treatment group, and control group smears Victor gram Peaceful ointment (Xian-Janssen Pharmaceutical Ltd.), 2 times a day, each 0.2g.
Before administration, measures auris dextra decortication area respectively with vernier caliper, be denoted as S0.It is inoculated with Candida albicans for 24 hours, inoculation portion Position skin starts to occur the decortication of scales of skin that peel off shape, and gradually increases, and occurs dermatitis sample skin lesion in the 4th day, papule, and color is red.It measures respectively Left and right ear decortication area, is denoted as SL and SR, is denoted as damaged area, auris dextra breakage area [(SR-S0)/S0] with [(S-S0)/S0] Left ear breakage area [(SL-S0)/S0] should be significantly greater than.Meanwhile 1 is randomly selected from each group rat, with sterile needle choicest Auricle decortication position is taken to apply ware, Anaerobic culturel 48h, it was demonstrated that be candida albicans infection.In inoculation Candida albicans the 5th day Administration, successive administration 10 days.From after first administration, before daily administration, measurement model ear breakage area, is denoted as Sn, then respectively N-th day mouse ear breakage area is Sn-S0;N-th day mouse ear breakage area is (Sn-S0)/S0 × 100%.Drug is investigated to skin The damaged healing effect of decortication caused by inflammation.
3) experimental result:
Compared with miconazole ointment, invention formulation can be obviously improved skin lesion after being administered 5 days, mouse ear is soft, and veins beneath the skin is obvious; Skin lesion area starts to subside after 10 days, and color tends to be normal;And the veins beneath the skin that remains unchanged after model control group skin 10 days is difficult to distinguish Recognize, color redness is hardened.Embodiment 1-10 preparation compositions are shown in Table 1 to the treatment results of animal Acne Model.
Table 1: investigation result (%) of the embodiment 1-3 drug to rat Cuo skin lesion auricle breakage area.
The above content is combine specific preferred embodiment to the further description done of the present invention, and it cannot be said that A specific embodiment of the invention is only limitted to this, for those of ordinary skill in the art to which the present invention belongs, is not taking off Under the premise of from the present invention, several simple deduction or replace can also be made, all shall be regarded as belonging to the present invention by being submitted Claims determine scope of patent protection.

Claims (6)

1. a kind of treat dermopathic Chinese medicine, which is characterized in that the raw material including following parts by weight: frutus cnidii: 25-35 parts, bitter Ginseng: 25-35 parts, the root of Dahurain angelica: 25-35 parts, cortex cinnamomi: 25-35 parts, dark plum: 25-35 parts, hawthorn: 25-35 parts, Radix Astragali: 25-35 parts, Rheum officinale: 25-35 parts, ginger: 35-45 parts, pericarpium zanthoxyli: 5-10 parts, Chinese prickly ash: 25-35 parts, radix rehmanniae preparata: 25-35 parts, mature vinegar: 450- 500 parts, borneol: 5-10 parts, betel nut: 25-35 parts, peach kernel: 45-55 parts, safflower: 45-55 parts, Chinese blister beetle: 20-30 parts.
2. a kind of dermopathic Chinese medicine is treated according to claim 1, which is characterized in that the mature vinegar is rice vinegar.
3. a kind of dermopathic Chinese medicine is treated according to claim 1, which is characterized in that the mature vinegar or to brew White wine.
4. a kind of preparation method for treating dermopathic Chinese medicine as described in claim 1, which is characterized in that including following step It is rapid:
By frutus cnidii, kuh-seng, the root of Dahurain angelica, cortex cinnamomi, dark plum, hawthorn, Radix Astragali, rheum officinale, ginger, pericarpium zanthoxyli, Chinese prickly ash, radix rehmanniae preparata, betel nut, peach kernel It is put into mature vinegar with safflower, sealed soak 7-9 days, after the 15-20min of small fire tanning later, moderate heat is endured after sealing is placed 1 day 30-40min processed;Borneol is added after being cooled to room temperature and removes the Chinese blister beetle on head and wing portion, takes filter after filtering after sealing 7-8 days Liquid obtains the Chinese medicine.
5. a kind of preparation method for treating dermopathic Chinese medicine according to claim 4, which is characterized in that by the filter Liquid is brewed into lotion and obtains the Chinese medicine.
6. a kind of preparation method for treating dermopathic Chinese medicine according to claim 4, which is characterized in that the Lao Chen Vinegar is brewing white spirit, alcoholic strength >=50 ° of the brewing white spirit.
CN201811410340.6A 2018-11-23 2018-11-23 It is a kind of to treat dermopathic Chinese medicine and preparation method thereof Pending CN109498782A (en)

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CN101156925A (en) * 2007-07-06 2008-04-09 周朝红 A traditional Chinese medicine preparation for treating children dermatosis
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Application publication date: 20190322