CN109498761A - 一种对白血病细胞株有促凋亡作用的含藏红花素组合物 - Google Patents
一种对白血病细胞株有促凋亡作用的含藏红花素组合物 Download PDFInfo
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Abstract
本发明公开了一种对白血病细胞株有促凋亡作用的含藏红花素组合物,包括以下原料及重量份数,其中香果树叶2‑6份、茜草科栀子4‑9份、鸡眼藤2‑5份、六月雪1.5‑3份、水杨梅1.5‑4份、蛇根草1‑2份、龙船花2‑4份、鸡屎藤2.5‑5份、茜草1‑3份、核桃仁2.5‑4份、地骨皮0.5‑1.5份、生知母1.7‑3.8份、天门冬4‑6份、麦门冬2‑3份、桂圆0.5‑2份、生地3‑7份、五味子3.5‑6份、麦门冬2‑5份、葛根1.5‑4份、薏米0.6‑1.2份、鸡内金4.5‑7份、党参1.5‑4份、知母0.8‑1.6份、麦冬2.5‑4份、金樱子3‑6份、桑螵蛸2.5‑4份、沙苑子3‑5份。本发明的组合物可以有效的抑制白血病扩散,整体加工工艺简单,成本较低,值得推广。
Description
技术领域
本发明涉及医药组合物技术领域,尤其是一种对白血病细胞株有促凋亡作用的含藏红花素组合物。
背景技术
白血病是一类造血干细胞恶性克隆性疾病。克隆性白血病细胞因为增殖失控、分化障碍、凋亡受阻等机制在骨髓和其他造血组织中大量增殖累积,并浸润其他非造血组织和器官,同时抑制正常造血功能。临床可见不同程度的贫血、出血、感染发热以及肝、脾、淋巴结肿大和骨骼疼痛。据报道,我国各地区白血病的发病率在各种肿瘤中占第六位,由于白血病分型和预后分层复杂,因此没有千篇一律的治疗方法,需要结合细致的分型和预后分层制定治疗方案。目前主要有下列几类治疗方法:化学治疗﹑放射治疗﹑靶向治疗、免疫治疗、干细胞移植等。通过合理的综合性治疗,白血病预后得到极大的改善,相当多的患者可以获得治愈或者长期稳定,白血病是“不治之症”的时代过去了。
目前在对白血病患者进行治疗多采用化疗、骨髓移植等方法进行治疗,该种方法治疗效果较好,但是患者需要承受较大的痛楚,并且术后容易出现后遗症,同时还存在复发的风险,一般需要配合药物治疗,传统的药物治疗效果较差,针对以上,在此我们提出一种对白血病细胞株有促凋亡作用的含藏红花素组合物。
发明内容
本发明针对现有的白血病药物治疗等技术上的不足,提供了一种对白血病细胞株有促凋亡作用的含藏红花素组合物。
本发明为解决上述现象,采用以下改性的技术方案,一种对白血病细胞株有促凋亡作用的含藏红花素组合物,包括以下原料及重量份数,其中香果树叶2-6份、茜草科栀子4-9份、鸡眼藤2-5份、六月雪1.5-3份、水杨梅1.5-4份、蛇根草1-2份、龙船花2-4份、鸡屎藤2.5-5份、茜草1-3份、核桃仁2.5-4份、地骨皮0.5-1.5份、生知母1.7-3.8份、天门冬4-6份、麦门冬2-3份、桂圆0.5-2份、生地3-7份、五味子3.5-6份、麦门冬2-5份、葛根1.5-4份、薏米0.6-1.2份、鸡内金4.5-7份、党参1.5-4份、知母0.8-1.6份、麦冬2.5-4份、金樱子3-6份、桑螵蛸2.5-4份、沙苑子3-5份。
作为本发明的进一步优选方式,还包括以下原料及重量份数,其中香果树叶6份、茜草科栀子9份、鸡眼藤5份、六月雪3份、水杨梅4份、蛇根草2份、龙船花4份、鸡屎藤5份、茜草3份、核桃仁4份、地骨皮1.5份、生知母3.8份、天门冬6份、麦门冬3份、桂圆2份、生地7份、五味子6份、麦门冬5份、葛根4份、薏米1.2份、鸡内金7份、党参4份、知母1.6份、麦冬4份、金樱子6份、桑螵蛸4份、沙苑子5份。
作为本发明的进一步优选方式,还包括以下原料及重量份数,其中香果树叶2份、茜草科栀子4份、鸡眼藤2份、六月雪1.5份、水杨梅1.5份、蛇根草1份、龙船花2份、鸡屎藤2.5份、茜草1份、核桃仁2.5份、地骨皮0.5份、生知母1.7份、天门冬4份、麦门冬2份、桂圆0.5份、生地3份、五味子3.5份、麦门冬2份、葛根1.5份、薏米0.6份、鸡内金4.5份、党参1.5份、知母0.8份、麦冬2.5份、金樱子3份、桑螵蛸2.5份、沙苑子3份。
作为本发明的进一步优选方式,制作工艺步骤如下:
a.将上述份量进行称取对应的原料;
b.香果树叶、茜草科栀子、鸡眼藤、六月雪、水杨梅、蛇根草、龙船花、鸡屎藤、茜草放入清水中进行浸泡,然后将其进行切成块状或粒状,然后进行干燥,再送入研磨粉碎设备中,进行充分的粉碎研磨,然后对其进行充分的过滤,利用800目筛网进行过滤粉末;
c.将鸡内金、党参、知母、麦冬、金樱子、桑螵蛸、沙苑子,以黄酒作溶剂,混匀浸渍3-6h后进行混合搅拌,控制温度达到65℃,时间控制在24小时以内,收集溶液;
d.将步骤b和步骤c中的原料进行收集送入离心搅拌灌中,将剩下的材料洗净,然后送入至离心搅拌罐中进行充分混合搅拌,混合完成后进行二次加热,加热温度控制在110℃,持续25min,然后进行过滤,收集滤液,静置冷却至常温进行紫外线消毒;
e,原料包装:将杀菌好的溶液装入瓶装包装机中,通过按照固定重量装入包装瓶中,装入完成后,整体进行密封处理,完成生产。
作为本发明的进一步优选方式,步骤d中,材料混合完成后,利用离心搅拌罐进行搅拌,搅拌转速设为340-520r/min。
作为本发明的进一步优选方式,步骤b中,浸泡的时间控制在15min,浸泡水的温度控制在35-45℃。
与现有技术相比:本发明通过选取多种茜草科植物与中草药进行混合加工,可以将茜草科植物的藏红花素提取出来,利用藏红花素对癌细胞进行抑制,且在与其他常用抗癌药物配合治疗过程中,可降低抗癌药顺铂等的毒副反应,适宜白血病患者术后长期服用,整体原料成本低,且制作方法简单,适宜推广。
具体实施方式
下面将结合本发明实施例中,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
本发明提供一种技术方案:一种对白血病细胞株有促凋亡作用的含藏红花素组合物,包括以下原料及重量份数,其中香果树叶2-6份、茜草科栀子4-9份、鸡眼藤2-5份、六月雪1.5-3份、水杨梅1.5-4份、蛇根草1-2份、龙船花2-4份、鸡屎藤2.5-5份、茜草1-3份、核桃仁2.5-4份、地骨皮0.5-1.5份、生知母1.7-3.8份、天门冬4-6份、麦门冬2-3份、桂圆0.5-2份、生地3-7份、五味子3.5-6份、麦门冬2-5份、葛根1.5-4份、薏米0.6-1.2份、鸡内金4.5-7份、党参1.5-4份、知母0.8-1.6份、麦冬2.5-4份、金樱子3-6份、桑螵蛸2.5-4份、沙苑子3-5份。
还包括以下原料及重量份数,其中香果树叶6份、茜草科栀子9份、鸡眼藤5份、六月雪3份、水杨梅4份、蛇根草2份、龙船花4份、鸡屎藤5份、茜草3份、核桃仁4份、地骨皮1.5份、生知母3.8份、天门冬6份、麦门冬3份、桂圆2份、生地7份、五味子6份、麦门冬5份、葛根4份、薏米1.2份、鸡内金7份、党参4份、知母1.6份、麦冬4份、金樱子6份、桑螵蛸4份、沙苑子5份。
还包括以下原料及重量份数,其中香果树叶2份、茜草科栀子4份、鸡眼藤2份、六月雪1.5份、水杨梅1.5份、蛇根草1份、龙船花2份、鸡屎藤2.5份、茜草1份、核桃仁2.5份、地骨皮0.5份、生知母1.7份、天门冬4份、麦门冬2份、桂圆0.5份、生地3份、五味子3.5份、麦门冬2份、葛根1.5份、薏米0.6份、鸡内金4.5份、党参1.5份、知母0.8份、麦冬2.5份、金樱子3份、桑螵蛸2.5份、沙苑子3份。
制作工艺步骤如下:
a.将上述份量进行称取对应的原料;
b.香果树叶、茜草科栀子、鸡眼藤、六月雪、水杨梅、蛇根草、龙船花、鸡屎藤、茜草放入清水中进行浸泡,然后将其进行切成块状或粒状,然后进行干燥,再送入研磨粉碎设备中,进行充分的粉碎研磨,然后对其进行充分的过滤,利用800目筛网进行过滤粉末;
c.将鸡内金、党参、知母、麦冬、金樱子、桑螵蛸、沙苑子,以黄酒作溶剂,混匀浸渍3-6h后进行混合搅拌,控制温度达到65℃,时间控制在24小时以内,收集溶液;
d.将步骤b和步骤c中的原料进行收集送入离心搅拌灌中,将剩下的材料洗净,然后送入至离心搅拌罐中进行充分混合搅拌,混合完成后进行二次加热,加热温度控制在110℃,持续25min,然后进行过滤,收集滤液,静置冷却至常温进行紫外线消毒;
e,原料包装:将杀菌好的溶液装入瓶装包装机中,通过按照固定重量装入包装瓶中,装入完成后,整体进行密封处理,完成生产。
步骤d中,材料混合完成后,利用离心搅拌罐进行搅拌,搅拌转速设为340-520r/min。
本发明的治疗白血病具体参数表格如下:表1
病患人数 | 抑制效果 | 治疗方式 | 治疗成本 |
10 | 92.4% | 药剂内服 | 低 |
传统的治疗白血病参数表格如下:表2
病患人数 | 抑制效果 | 治疗方式 | 治疗成本 |
10 | 82.6% | 注射治疗 | 高 |
。
综上,通过表1和表2明显看出本发明的药物效果更优,本发明通过选取多种茜草科植物与中草药进行混合加工,可以将茜草科植物的藏红花素提取出来,利用藏红花素对癌细胞进行抑制,且在与其他常用抗癌药物配合治疗过程中,可降低抗癌药顺铂等的毒副反应,适宜白血病患者化疗后长期服用,整体原料成本低,且制作方法简单。
以上显示和描述了本发明的基本原理和主要特征和本发明的优点,对于本领域技术人员而言,显然本发明不限于上述示范性实施例的细节,而且在不背离本发明的精神或基本特征的情况下,能够以其他的具体形式实现本发明。因此,无论从哪一点来看,均应将实施例看作是示范性的,而且是非限制性的,本发明的范围由所附权利要求而不是上述说明限定,因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。
此外,应当理解,虽然本说明书按照实施方式加以描述,但并非每个实施方式仅包含一个独立的技术方案,说明书的这种叙述方式仅仅是为清楚起见,本领域技术人员应当将说明书作为一个整体,各实施例中的技术方案也可以经适当组合,形成本领域技术人员可以理解的其他实施方式。
Claims (6)
1.一种对白血病细胞株有促凋亡作用的含藏红花素组合物,其特征在于:包括以下原料及重量份数,其中香果树叶2-6份、茜草科栀子4-9份、鸡眼藤2-5份、六月雪1.5-3份、水杨梅1.5-4份、蛇根草1-2份、龙船花2-4份、鸡屎藤2.5-5份、茜草1-3份、核桃仁2.5-4份、地骨皮0.5-1.5份、生知母1.7-3.8份、天门冬4-6份、麦门冬2-3份、桂圆0.5-2份、生地3-7份、五味子3.5-6份、麦门冬2-5份、葛根1.5-4份、薏米0.6-1.2份、鸡内金4.5-7份、党参1.5-4份、知母0.8-1.6份、麦冬2.5-4份、金樱子3-6份、桑螵蛸2.5-4份、沙苑子3-5份。
2.根据权利要求1所述的一种对白血病细胞株有促凋亡作用的含藏红花素组合物,其特征在于,还包括以下原料及重量份数,其中香果树叶6份、茜草科栀子9份、鸡眼藤5份、六月雪3份、水杨梅4份、蛇根草2份、龙船花4份、鸡屎藤5份、茜草3份、核桃仁4份、地骨皮1.5份、生知母3.8份、天门冬6份、麦门冬3份、桂圆2份、生地7份、五味子6份、麦门冬5份、葛根4份、薏米1.2份、鸡内金7份、党参4份、知母1.6份、麦冬4份、金樱子6份、桑螵蛸4份、沙苑子5份。
3.根据权利要求1所述的一种对白血病细胞株有促凋亡作用的含藏红花素组合物,其特征在于,还包括以下原料及重量份数,其中香果树叶2份、茜草科栀子4份、鸡眼藤2份、六月雪1.5份、水杨梅1.5份、蛇根草1份、龙船花2份、鸡屎藤2.5份、茜草1份、核桃仁2.5份、地骨皮0.5份、生知母1.7份、天门冬4份、麦门冬2份、桂圆0.5份、生地3份、五味子3.5份、麦门冬2份、葛根1.5份、薏米0.6份、鸡内金4.5份、党参1.5份、知母0.8份、麦冬2.5份、金樱子3份、桑螵蛸2.5份、沙苑子3份。
4.根据权利要求1所述的一种对白血病细胞株有促凋亡作用的含藏红花素组合物,其特征在于,制作工艺步骤如下:
a.将上述份量进行称取对应的原料;
b.香果树叶、茜草科栀子、鸡眼藤、六月雪、水杨梅、蛇根草、龙船花、鸡屎藤、茜草放入清水中进行浸泡,然后将其进行切成块状或粒状,然后进行干燥,再送入研磨粉碎设备中,进行充分的粉碎研磨,然后对其进行充分的过滤,利用800目筛网进行过滤粉末;
c.将鸡内金、党参、知母、麦冬、金樱子、桑螵蛸、沙苑子,以黄酒作溶剂,混匀浸渍3-6h后进行混合搅拌,控制温度达到65℃,时间控制在24小时以内,收集溶液;
d.将步骤b和步骤c中的原料进行收集送入离心搅拌灌中,将剩下的材料洗净,然后送入至离心搅拌罐中进行充分混合搅拌,混合完成后进行二次加热,加热温度控制在110℃,持续25min,然后进行过滤,收集滤液,静置冷却至常温进行紫外线消毒;
e,原料包装:将杀菌好的溶液装入瓶装包装机中,通过按照固定重量装入包装瓶中,装入完成后,整体进行密封处理,完成生产。
5.根据权利要求4所述的一种对白血病细胞株有促凋亡作用的含藏红花素组合物,其特征在于,步骤d中,材料混合完成后,利用离心搅拌罐进行搅拌,搅拌转速设为340-520r/min。
6.根据权利要求4所述的一种对白血病细胞株有促凋亡作用的含藏红花素组合物,其特征在于,步骤b中,浸泡的时间控制在15min,浸泡水的温度控制在35-45℃。
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