CN109498710B - Hemostatic Mongolian medicine and preparation method thereof - Google Patents

Hemostatic Mongolian medicine and preparation method thereof Download PDF

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Publication number
CN109498710B
CN109498710B CN201811615565.5A CN201811615565A CN109498710B CN 109498710 B CN109498710 B CN 109498710B CN 201811615565 A CN201811615565 A CN 201811615565A CN 109498710 B CN109498710 B CN 109498710B
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parts
powder
hemostatic
raw materials
medicine
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CN109498710A (en
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李晓波
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Fuxin Mongolian Autonomous County Mongolian Medical Hospital
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Fuxin Mongolian Autonomous County Mongolian Medical Hospital
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/47Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/413Gall bladder; Bile
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/30Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/86Violaceae (Violet family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Abstract

The invention relates to a hemostatic Mongolian medicine, and relates to the technical field of traditional Chinese medicine formulas. The hemostatic Mongolian medicament is prepared from the following raw materials in parts by weight: 5-20 parts of humifuse euphorbia herb, 5-20 parts of hairyvein agrimonia herb and bud, 5-20 parts of bunge corydalis herb, 5-20 parts of lithospermum and 0.5-10 parts of bear gall, and the preparation method comprises the steps of weighing, crushing, mixing, packaging and sterilizing. The invention overcomes the defects of the prior art and provides the hemostatic Mongolian medicine and the preparation method thereof, which have the advantages of clear action mechanism, reduced ineffective components, small dosage, quick effect, low toxic and side effects and convenient taking.

Description

Hemostatic Mongolian medicine and preparation method thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine formulas, in particular to a hemostatic Mongolian medicine and a preparation method thereof.
Background
Mongolian medicine has unique treatment methods for hematemesis, hematochezia, menorrhagia, traumatic hemorrhage, liver cirrhosis and other hemorrhagic diseases, and Mongolian medicines mainly used for clearing liver heat and clearing blood heat and used for astringing pus blood and stopping vomiting are used as adjuvant medicines to form various formulas. Although the Mongolian medicine has good treatment effect, due to the lack of modern technical means, the action mechanism of the medicine is fuzzy, the effective components are more uncertain, the effective components and the ineffective components are mixed together, the dosage is large, the effect is slow, the medicine is inconvenient to take, and the storage and the transportation are inconvenient, so that the development and the utilization of the Mongolian medicine are limited, and the standard production of the Mongolian medicine is imperative.
Disclosure of Invention
The technical problem to be solved by the invention is to overcome the defects of the prior art and provide a hemostatic Mongolian medicine and a preparation method thereof, which have the advantages of clear action mechanism, reduced ineffective components, small dosage, quick effect, low toxic and side effects and convenient administration.
In order to solve the technical problems, the technical scheme provided by the invention is as follows: the hemostatic Mongolian medicine is prepared from the following raw materials in parts by weight: 5-20 parts of humifuse euphorbia herb, 5-20 parts of hairyvein agrimonia herb and bud, 5-20 parts of bunge corydalis herb, 5-20 parts of lithospermum and 0.5-10 parts of bear gall.
As an improvement, the medicament is any one of pharmaceutical dosage forms.
A preparation method of hemostatic Mongolian medicine comprises the following steps:
a. weighing: weighing the raw materials, mixing, and selecting to remove impurities;
b. crushing: under the condition that the illuminance is more than or equal to 300 lux, crushing the raw materials by a clean crusher, crushing the raw materials into coarse powder and then into fine powder, respectively putting the coarse powder and the fine powder into a stainless steel barrel, covering the stainless steel barrel, filling the stainless steel barrel, and hanging a material card, wherein the fine powder is required to pass through a 80-mesh screen;
c. mixing: mixing the fine powder of the raw materials into medicinal powder by a mixer for 50-70 minutes, and filling the medicinal powder into a clean container for sealing after the uniformity of the medicinal powder is detected to be qualified;
d. packaging: before operation, checking that all parts of the automatic packaging machine work normally, after disinfection and cleaning, operating and bagging, and simultaneously checking that the sealing performance is qualified and the appearance is qualified;
e. and (3) sterilization: high-pressure sterilization, the sterilization requirements are as follows: aerobic bacteria is less than or equal to 10000cfu/g, mould is less than or equal to 100cfu/g, microzyme is less than or equal to 100cfu/g, Escherichia coli cannot be detected, salmonella cannot be detected, and cholate-resistant gram-negative bacteria are less than 100 cfu/g.
As a modification, the fine powder in the step b needs to contain powder which passes through a 100-mesh screen and is not less than 95% by weight of the total weight.
As an improvement, the production site of any one of the steps a, b, c and D requires the temperature to be 18-26 ℃, the humidity to be less than or equal to 65 percent and the cleaning grade to be grade D.
As an improvement, the operation steps for detecting the uniformity of the medicinal powder in the step c are as follows: taking appropriate amount of the medicinal powder, spreading on smooth white paper for 4-6cm2The surface of the product is flattened, and the product is observed in bright places, has uniform color and no decorative patterns or color spots, and is qualified.
The invention has the following advantages:
humifuse euphorbia herb: it is pungent and mild in nature and has the effects of clearing heat and removing toxicity, cooling blood and stopping bleeding, and removing dampness and eliminating jaundice. Can be used for treating dysentery, diarrhea, hemoptysis, hematuria, hematochezia, metrorrhagia, furuncle, carbuncle, swelling, and jaundice due to damp-heat pathogen.
Agrimony: slight smell and slightly bitter taste, and can be used for hemoptysis, hematemesis, metrorrhagia, metrostaxis, malaria, bloody dysentery, carbuncle, sore, pruritus vulvae, leukorrhagia, and internal injury due to overstrain.
Corydalis Bungeana (L.) Merr: is cold in nature, bitter in taste, and slightly toxic, and has effects of clearing heat and detoxicating, and can be used for treating epidemic febrile disease, hyperpyrexia, dysphoria, influenza, infectious hepatitis, nephritis, lymphoid tuberculosis, parotitis, furuncle and other pyogenic infections.
Lithospermum: bitter in property and cold in nature, has the main effects of cooling blood, promoting blood circulation, clearing heat and removing toxicity. It can be used for treating warm heat macula, damp-heat jaundice, purpura, emesis, epistaxis, hematuria, stranguria with turbid urine, constipation due to heat accumulation, burn, eczema, erysipelas, and carbuncle.
Bear gall: has faint scent or fishy smell, is extremely bitter after being dissolved in mouth, and has the effects of clearing away heat and toxic materials, calming the liver, improving eyesight, killing parasites and stopping bleeding.
The raw materials of the invention are all natural medicines, and the invention has the advantages of no drug resistance, no residue and no side effect.
Detailed Description
The present invention will be described in further detail with reference to examples.
Example 1
In the specific implementation of the invention, the hemostatic Mongolian medicine is prepared from the following raw materials in parts by weight: 5 parts of humifuse euphorbia herb, 5 parts of hairyvein agrimony, 5 parts of bunge corydalis herb, 5 parts of lithospermum and 0.5 part of bear gall, wherein the medicament is any one of pharmaceutical dosage forms.
A preparation method of hemostatic Mongolian medicine comprises the following steps:
a. weighing: weighing the raw materials, mixing, and selecting to remove impurities;
b. crushing: under the condition that the illuminance is more than or equal to 300 lux, crushing the raw materials by a clean crusher, crushing the raw materials into coarse powder and then into fine powder, respectively putting the coarse powder and the fine powder into a stainless steel barrel, covering the stainless steel barrel, filling the stainless steel barrel, and hanging a material card, wherein the fine powder is required to pass through a 80-mesh screen;
c. mixing: mixing the fine powder of the raw materials into medicinal powder by a mixer for 50 minutes, and filling the medicinal powder into a clean container for sealing after the uniformity of the medicinal powder is detected to be qualified;
d. packaging: before operation, checking that all parts of the automatic packaging machine work normally, after disinfection and cleaning, operating and bagging, and simultaneously checking that the sealing performance is qualified and the appearance is qualified;
e. and (3) sterilization: high-pressure sterilization, the sterilization requirements are as follows: aerobic bacteria is less than or equal to 10000cfu/g, mould is less than or equal to 100cfu/g, microzyme is less than or equal to 100cfu/g, Escherichia coli cannot be detected, salmonella cannot be detected, and cholate-resistant gram-negative bacteria are less than 100 cfu/g. The fine powder in the step b needs to pass through a 100-mesh screen and has the weight not lower than 95% of total weight, the production site in any one of the steps a, b, c and D needs to have the temperature of 18-26 ℃, the humidity not more than 65% and the cleaning grade D, and the operation steps for detecting the uniformity of the medicinal powder in the step c are as follows: taking appropriate amount of medicinal powder, spreading on smooth white paper for 4cm2The surface of the product is flattened, and the product is observed in bright places, has uniform color and no decorative patterns or color spots, and is qualified.
Example 2
In the specific implementation of the invention, the hemostatic Mongolian medicine is prepared from the following raw materials in parts by weight: 20 parts of humifuse euphorbia herb, 20 parts of hairyvein agrimony, 20 parts of bunge corydalis herb, 20 parts of lithospermum and 10 parts of bear gall, wherein the medicament is any one of pharmaceutical dosage forms.
A preparation method of hemostatic Mongolian medicine comprises the following steps:
a. weighing: weighing the raw materials, mixing, and selecting to remove impurities;
b. crushing: under the condition that the illuminance is more than or equal to 300 lux, crushing the raw materials by a clean crusher, crushing the raw materials into coarse powder and then into fine powder, respectively putting the coarse powder and the fine powder into a stainless steel barrel, covering the stainless steel barrel, filling the stainless steel barrel, and hanging a material card, wherein the fine powder is required to pass through a 80-mesh screen;
c. mixing: mixing the fine powder of the raw materials into medicinal powder by a mixer for 70 minutes, and filling the medicinal powder into a clean container for sealing after the uniformity of the medicinal powder is detected to be qualified;
d. packaging: before operation, checking that all parts of the automatic packaging machine work normally, after disinfection and cleaning, operating and bagging, and simultaneously checking that the sealing performance is qualified and the appearance is qualified;
e. and (3) sterilization: high-pressure sterilization, the sterilization requirements are as follows: aerobic bacteria is less than or equal to 10000cfu/g, mould is less than or equal to 100cfu/g, microzyme is less than or equal to 100cfu/g, Escherichia coli cannot be detected, salmonella cannot be detected, and cholate-resistant gram-negative bacteria are less than 100 cfu/g. The fine powder in the step b needs to pass through a 100-mesh screen and has the weight not lower than 95% of total weight, the production site in any one of the steps a, b, c and D needs to have the temperature of 18-26 ℃, the humidity not more than 65% and the cleaning grade D, and the operation steps for detecting the uniformity of the medicinal powder in the step c are as follows: taking appropriate amount of medicinal powder, spreading on smooth white paper for 6cm2The surface of the product is flattened, and the product is observed in bright places, has uniform color and no decorative patterns or color spots, and is qualified.
Example 3
In the specific implementation of the invention, the hemostatic Mongolian medicine is prepared from the following raw materials in parts by weight: 13 parts of humifuse euphorbia herb, 13 parts of hairyvein agrimony, 13 parts of bunge corydalis herb, 12 parts of lithospermum and 6 parts of bear gall, wherein the medicament is any one of pharmaceutical dosage forms.
A preparation method of hemostatic Mongolian medicine comprises the following steps:
a. weighing: weighing the raw materials, mixing, and selecting to remove impurities;
b. crushing: under the condition that the illuminance is more than or equal to 300 lux, crushing the raw materials by a clean crusher, crushing the raw materials into coarse powder and then into fine powder, respectively putting the coarse powder and the fine powder into a stainless steel barrel, covering the stainless steel barrel, filling the stainless steel barrel, and hanging a material card, wherein the fine powder is required to pass through a 80-mesh screen;
c. mixing: mixing the fine powder of the raw materials into medicinal powder by a mixer for 60 minutes, and filling the medicinal powder into a clean container for sealing after the uniformity of the medicinal powder is detected to be qualified;
d. packaging: before operation, checking that all parts of the automatic packaging machine work normally, after disinfection and cleaning, operating and bagging, and simultaneously checking that the sealing performance is qualified and the appearance is qualified;
e. and (3) sterilization: high-pressure sterilization, the sterilization requirements are as follows: aerobic bacteria is less than or equal to 10000cfu/g, mould is less than or equal to 100cfu/g, microzyme is less than or equal to 100cfu/g, Escherichia coli cannot be detected, salmonella cannot be detected, and cholate-resistant gram-negative bacteria are less than 100 cfu/g. The fine powder in the step b needs to pass through a 100-mesh screen and has the weight not lower than 95% of total weight, the production site in any one of the steps a, b, c and D needs to have the temperature of 18-26 ℃, the humidity not more than 65% and the cleaning grade D, and the operation steps for detecting the uniformity of the medicinal powder in the step c are as follows: taking appropriate amount of medicinal powder, spreading on smooth white paper for 5cm2The surface of the product is flattened, and the product is observed in bright places, has uniform color and no decorative patterns or color spots, and is qualified.
The raw materials of the invention are all natural medicines, and the invention has the advantages of no drug resistance, no residue and no side effect.
The significant effect of the invention for haemostasis is illustrated by specific treatment examples:
therapeutic example 1
Zhouqi, male, 44 years old, Fumon county, New civilian county. Pale complexion and fatigue for more than ten years. Aplastic anemia is diagnosed in the process of bone puncture in other areas, and the improvement is not seen after the oral administration of the conaglong, the cyclosporine and the traditional Chinese medicine. The three diagnostic methods are that the three diagnostic methods are used for diagnosing the blood failure, namely a non-digestion type, and the disease condition is improved after the Mongolian medicine fructus Tsaoko-twenty-one pill and the blood stasis-purple pill are orally taken according to the treatment principle of regulating spleen and invigorating stomach, separating clear and turbid essence and balancing three roots. 3, before the day, because the nasal bleeding is not continuous after the cold, the cotton swab is filled by a patient to stop bleeding, a small amount of bleeding still exists, and the emergency treatment blood circulation routine shows that: WBC 1.86X 109/L, HGB39g/L, PLT 16X 109/L. After the patient is admitted, the patient is stopped bleeding by applying a renal tampon nasal cavity plugging operation, the bleeding is not obviously improved, the blood still seeps out, and the medicine with the formula is immediately taken three times a day. The next day, the bleeding decreased. After 3 days, no blood seeped, the tamponade was removed, and no bleeding was seen in the nasal cavity. And (5) carrying out subsequent symptomatic blood transfusion treatment, and continuing to take the Mongolian medicine orally.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims (5)

1. The hemostatic Mongolian medicine is characterized by being prepared from the following raw materials in parts by weight: 5-20 parts of humifuse euphorbia herb, 5-20 parts of hairyvein agrimonia herb and bud, 5-20 parts of bunge corydalis herb, 5-20 parts of lithospermum and 0.5-10 parts of bear gall.
2. The method for preparing a hemostatic Mongolian medicine, according to claim 1, comprising the steps of:
a. weighing: weighing the raw materials, mixing, and selecting to remove impurities;
b. crushing: under the condition that the illuminance is more than or equal to 300 lux, crushing the raw materials by a clean crusher, crushing the raw materials into coarse powder and then into fine powder, respectively putting the coarse powder and the fine powder into a stainless steel barrel, covering the stainless steel barrel, filling the stainless steel barrel, and hanging a material card, wherein the fine powder is required to pass through a 80-mesh screen;
c. mixing: mixing the fine powder of the raw materials into medicinal powder by a mixer for 50-70 minutes, and filling the medicinal powder into a clean container for sealing after the uniformity of the medicinal powder is detected to be qualified;
d. packaging: before operation, checking that all parts of the automatic packaging machine work normally, after disinfection and cleaning, operating and bagging, and simultaneously checking that the sealing performance is qualified and the appearance is qualified;
e. and (3) sterilization: high-pressure sterilization, the sterilization requirements are as follows: aerobic bacteria are less than or equal to 10000cfu/g, mould is less than or equal to 100cfu/g, microzyme is less than or equal to 100cfu/g, escherichia coli cannot be detected, salmonella cannot be detected, and cholate-resistant gram-negative bacteria cannot be detected.
3. The method for preparing a hemostatic Mongolian medicine according to claim 2, wherein the method comprises the following steps: the fine powder in the step b needs to pass through a 100-mesh screen and has the weight not less than 95% of the total weight.
4. The method for preparing a hemostatic Mongolian medicine according to claim 2, wherein the method comprises the following steps: the production site of any one of the steps a, b, c and D requires the temperature to be 18-26 ℃, the humidity to be less than or equal to 65 percent and the cleaning grade to be grade D.
5. The method for preparing a hemostatic Mongolian medicine according to claim 2, wherein the method comprises the following steps: the operation steps for detecting the uniformity of the medicinal powder in the step c are as follows: proper amount of medicine powder is taken, the medicine powder is placed on smooth white paper and is tiled by 4-6cm, the surface of the medicine powder is flattened, and the medicine powder is observed in a bright place, has uniform color and luster, has no decorative patterns or color spots and is qualified.
CN201811615565.5A 2018-12-27 2018-12-27 Hemostatic Mongolian medicine and preparation method thereof Active CN109498710B (en)

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CN109498710B true CN109498710B (en) 2021-07-02

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