CN109498487A - Cosmetic composition and its preparation method and application is repaired in a kind of moisturizing - Google Patents
Cosmetic composition and its preparation method and application is repaired in a kind of moisturizing Download PDFInfo
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- CN109498487A CN109498487A CN201811421773.1A CN201811421773A CN109498487A CN 109498487 A CN109498487 A CN 109498487A CN 201811421773 A CN201811421773 A CN 201811421773A CN 109498487 A CN109498487 A CN 109498487A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
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Abstract
The invention discloses a kind of moisturizings to repair cosmetic composition and its preparation method and application.Cosmetic composition is repaired in the moisturizing, by weight percentage, it include: carbomer 0.1-1%, propylene glycol 1-10%, glycerol 1-10%, glycine betaine 1-8%, Sodium Hyaluronate 0.1-1%, xylitol 1-10%, saccharomycetes to make fermentation extract 1-20%, grape seed extract 2-20%, triethanolamine 0.1-1%, glucan 1-8%, allantoin 0.05-0.5%, panthenol 0.1-5%, 1,2- hexylene glycol 0.1-1%, decoyl hydroximic acid 0.01-0.1%, Sensiva SC50 0.01-0.5%, water surplus.Cosmetic composition is repaired in the moisturizing to be had the characteristics that use obvious effect, performance mild, non-stimulated, without side-effects, it can effectively clear free radical extra in human body, it promotes blood circulation, by adjusting face's microcirculation and metabolic balance, local edema and extravasated blood are eliminated, red capillary can be effectively eliminated, make skin is in activated state, increase cutaneous immunisation power and regeneration physiological activity, improves skin elasticity.
Description
Technical field
The present invention relates to cosmetic technical field, in particular to cosmetic composition and preparation method thereof is repaired in a kind of moisturizing
And application.
Background technique
With the progress of society and economic development and the continuous improvement of living standards of the people, people are to beauty and skin care
The requirement of cosmetic is also higher and higher, increasingly develops to the direction of " naturalization, nutrient laden, curative effect ".Human skin is especially
Cuticula is one of natural barrier to resist external harmful substance intrusion body, and the barrier action of skin makes most skin care item not
Easily across this effective, selective barrier of human skin.Research shows that cuticula is a kind of close structure, it is similar to
The construction of " brick and cement mixing are inlayed ", constitutes one " wall ".The keratocyte of hydrophily keratin constitutes " brick ", is wrapped
It is embedded in " cement " structure being made of multilayer lipid layer, fatty acid, cholesterol, the cholesterol ester of neural acid amide.Most of points
Son need to enter internal via cell and intercellular minim gap.Therefore skin care item will be absorbed by the body, and need it that can pass through
These gaps or the structure for upsetting this densification enter deep layer and body circulation by skin surface.There are many shields on the market at present
Effective component in skin product is difficult to absorbing transmission from skin, and causes actual efficacy little.
Summary of the invention
It is an object of that present invention to provide a kind of moisturizings to repair cosmetic composition and its preparation method and application, on solving
State technical problem.
In order to solve the above-mentioned technical problem, the technical solution of the present invention is as follows:
In a first aspect, cosmetic composition is repaired in a kind of moisturizing provided by the invention, by weight percentage, comprising: card
Wave nurse 0.1-1%, propylene glycol 1-10%, glycerol 1-10%, glycine betaine 1-8%, Sodium Hyaluronate 0.1-1%, xylitol 1-
10%, saccharomycetes to make fermentation extract 1-20%, grape seed extract 2-20%, triethanolamine 0.1-1%, glucan 1-8%, urine
Bursin 0.05-0.5%, panthenol 0.1-5%, 1,2- hexylene glycol 0.1-1%, decoyl hydroximic acid 0.01-0.1%, ethylhexyl are sweet
Oily 0.01-0.5%, water surplus.
Preferably, cosmetic composition is repaired in the moisturizing, by weight percentage, comprising: carbomer 0.1-0.5%,
Propylene glycol 5-10%, glycerol 4-9%, glycine betaine 2-6%, Sodium Hyaluronate 0.1-0.5%, xylitol 1-5%, saccharomycetes to make fermentation
Extract 5-13%, grape seed extract 5-15%, triethanolamine 0.1-0.5%, glucan 2-5%, allantoin 0.1-
0.2%, panthenol 0.5-2%, 1,2- hexylene glycol 0.2-0.8%, decoyl hydroximic acid 0.01-0.05%, Sensiva SC50 0.01-
0.1%, water surplus.
Preferably, cosmetic composition is repaired in the moisturizing, by weight percentage, comprising: carbomer 0.3%, the third two
Alcohol 7%, glycerol 6%, glycine betaine 4%, Sodium Hyaluronate 0.3%, xylitol 2%, saccharomycetes to make fermentation extract 8%, grape pip
Extract 10%, triethanolamine 0.3%, glucan 3%, allantoin 0.12%, panthenol 1%, 1,2- hexylene glycol 0.6%, decoyl
Hydroximic acid 0.02%, Sensiva SC50 0.03%, water surplus.
Preferably, cosmetic composition is repaired in the moisturizing, by weight percentage, comprising: carbomer 0.1%, the third two
Alcohol 10%, glycerol 4%, glycine betaine 6%, Sodium Hyaluronate 0.1%, xylitol 1%, saccharomycetes to make fermentation extract 13%, grape
It is seed extract 5%, triethanolamine 0.1%, glucan 5%, allantoin 0.2%, panthenol 0.5%, 1,2- hexylene glycol 0.2%, pungent
Acyl hydroximic acid 0.05%, Sensiva SC50 0.01%, water surplus.
Preferably, cosmetic composition is repaired in the moisturizing, by weight percentage, comprising: carbomer 0.5%, the third two
Alcohol 5%, glycerol 9%, glycine betaine 2%, Sodium Hyaluronate 0.5%, xylitol 5%, saccharomycetes to make fermentation extract 5%, grape pip
Extract 15%, triethanolamine 0.5%, glucan 2%, allantoin 0.1%, panthenol 2%, 1,2- hexylene glycol 0.8%, decoyl hydroxyl
Oxime acid 0.01%, Sensiva SC50 0.1%, water surplus.
Preferably, the grape seed extract is to be made using following methods:
It is the ratio of 1:5~10 according to the w/v mg/ml of the grape pip and solvent, grape pip and solvent is mixed
2~4h is stirred after conjunction under conditions of 80-100 DEG C, is collected by filtration to obtain the first filtrate and the first filter residue；According to first filter
The w/v mg/ml of slag and solvent is the ratio of 1:5~10, at 80-100 DEG C after first filter residue and solvent are mixed
Under conditions of stir 1~3h, be collected by filtration to obtain the second filtrate and the second filter residue, by first filtrate and second filtrate
It is concentrated under reduced pressure after mixing and the grape seed extract is made；The solvent is the mixed solution of ethyl alcohol, glycerol and water.
Preferably, the saccharomycetes to make fermentation extract is Fermentation in Pichia Pastoris lysis filtrate.
It is further preferred that the Fermentation in Pichia Pastoris lysis filtrate extracts from the fermentation of pichia pastoris yeast
Product.
Second aspect, a kind of preparation side of moisturizing reparation cosmetic composition as described in relation to the first aspect provided by the invention
Method includes the following steps:
Water, carbomer, propylene glycol, glycerol, glycine betaine, Sodium Hyaluronate are added in emulsion pot and are heated to 85-90 DEG C simultaneously
20~60min is kept the temperature, after the temperature in emulsion pot is adjusted to not higher than 45 DEG C, triethanolamine is added, stirs 3~10min, so
Xylitol, saccharomycetes to make fermentation extract, grape seed extract, glucan, allantoin, panthenol are added afterwards to stir evenly, adds
1,2- hexylene glycol, decoyl hydroximic acid, Sensiva SC50 stir evenly, and moisturizing can be obtained and repair cosmetic composition.
The third aspect, the moisturizing of one kind provided by the invention as described in relation to the first aspect repair cosmetic composition in preparationization
Application in cosmetic.
It is understood that anyone skilled in the art can be by provided by the invention such as first party
Moisturizing described in face is repaired cosmetic composition and is used to prepare in cosmetics, including but not limited to following method: by the moisturizing
Cosmetic composition is repaired to be added into the cosmetics such as facial cleanser, Essence, cream, cream.
Compared with prior art, the beneficial effects of the present invention are:
(1) net face stoste provided by the invention has the spy mild, non-stimulated, without side-effects using obvious effect, performance
Point can effectively clear free radical extra in human body, promote blood circulation, and by adjusting face's microcirculation and metabolic balance, disappear
Except local edema and extravasated blood, red capillary can be effectively eliminated, make skin is in activated state, increases cutaneous immunisation power and regeneration
Physiological activity improves skin elasticity；Grape seed extract, saccharomycetes to make fermentation extract and other components in formula of the invention
It is indispensable with different effective component, there is the synergistic effect of complementary collaboration, wherein in formula the effect of each component such as
Under:
Propylene glycol: for polyalcohol, have the function of antimicrobial antiphlogistic and inhibit bacterial proliferation；
Glycerol: mostly using moisturizer, with widely applicable skin；
Carbomer: thickener, the stabilization for increasing system assign salubrious skin sense；
Glycine betaine: amino acid rich in has stronger inhibition skin because of the dry problem.
Sodium Hyaluronate: supplement flesh bottom water point inhibits skin because uncomfortable or dry caused by water shortage；
Glucan: the polysaccharide that the active structure of glucan is made of glucose unit, it can activated macrophage,
Neutrophils etc. stimulate the immune of body to improve the content of leukin, the basic element of cell division and distinct antibodies comprehensively
System；
Xylitol: xylitol is that one kind can be used as medicament, nutritional agents, the polyalcohol of moisturizer.Xylitol has very strong
Hygroscopicity, purity more high-hygroscopicity are better.Xylitol can lose one in portion in the molecule in the presence of higher temperature and inorganic acid
Molecular water becomes anhydro xylitol.The aqueous solution of xylitol has complexing, can be while moisture absorption, can be with air dirt
Minerals in dye generate complex compound；
Grape seed extract；Grape seed extract is pure natural substance, is that the plant origin found so far most efficiently resists
One of oxidant, experiments have shown that, antioxidant effect is 30-50 times of vitamin C and vitamin E；
Fermentation in Pichia Pastoris lysis object filtrate can replace ancient antibiotic, have promote Skin Cell regeneration and
Wound healing, anti-aging, prevention scar, the effect for improving cutaneous immunisation power, also have excellent bactericidal effect, provide for skin interior
Source sexual trauma healing factor reaches anti-acne of quickly reducing swelling to improve the ability of skin rejecting ambient microorganism and repair power
Effect；The sterilization of phytosterol, anti-acne effect is obvious and safety is mild；
Triethanolamine: the comprehensive carbomer of PH regulator forms stoste；
Allantoin: have and promote cell growth, accelerate wound healing, the physiological functions such as cutin-softening albumen；
Panthenol: nursing role on the skin shows as the moisturizer penetrated deep into, stimulates the growth of epithelial cell, promotes
Wound healing plays antiinflammation；
1,2- hexylene glycol: polyalcohol is conducive to increase the formula system shelf-life, inhibits harmful bacterial growth；
Decoyl hydroximic acid: being a kind of safe ingredient, and decoyl hydroximic acid is a kind of organic acid that can play antisepsis, main
It is used for cosmetic humectant and preservative；
Sensiva SC50: being a kind of emollient that spreading property is moderate, moisturizer and wetting agent, it can match in raising
There is soft and smooth skin sense again while square moisturizing effect；
(2) moisturizing provided by the invention repairs cosmetic composition without antibiotic without acute skin irritation, has extremely
Extensive security value；
(3) simple production process of cosmetic composition is repaired in moisturizing provided by the invention, green safe, is had high
Economic value.
(4) raw material sources of the present invention are abundant, quality-high and inexpensive, are conducive to generate bigger economy and society effect
Benefit.
Specific embodiment
Specific embodiments of the present invention will be further explained below.It should be noted that for these implementations
The explanation of mode is used to help understand the present invention, but and does not constitute a limitation of the invention.In addition, invention described below
Technical characteristic involved in each embodiment can be combined with each other as long as they do not conflict with each other.
Yeast fermentation lysis filtrate in following embodiment and comparative example extracts from the tunning of pichia pastoris yeast.
Grape seed extract in following embodiment and comparative example is to be made using following methods:
The ratio for being 1:10 according to the w/v mg/ml of the grape pip and solvent mixes grape pip and solvent
3h is stirred under conditions of 90 DEG C afterwards, is collected by filtration to obtain the first filtrate and the first filter residue；According to first filter residue and solvent
W/v mg/ml be 1:5 ratio, will first filter residue and solvent mix after stir 2h under conditions of 90 DEG C,
It is collected by filtration to obtain the second filtrate and the second filter residue, is concentrated under reduced pressure and is made after first filtrate and second filtrate are mixed
The grape seed extract；The solution that the solvent is ethyl alcohol, glycerol and water are mixed according to the volume ratio of 0.5:0.1:1.
Embodiment 1
The preparation method that cosmetic composition is repaired in a kind of moisturizing provided in this embodiment includes the following steps:
Take following raw materials in percentage by weight: carbomer 0.3%, propylene glycol 7%, glycerol 6%, glycine betaine 4%,
Sodium Hyaluronate 0.3%, xylitol 2%, saccharomycetes to make fermentation lysate filtrate 8%, grape seed extract 10%, triethanolamine
0.3%, glucan 3%, allantoin 0.12%, panthenol 1%, 1,2- hexylene glycol 0.6%, decoyl hydroximic acid 0.02%, ethyl hexyl
Base glycerol 0.03%, water surplus；
Water, carbomer, propylene glycol, glycerol, glycine betaine, Sodium Hyaluronate are added in emulsion pot and are heated to 85-90 DEG C simultaneously
30min is kept the temperature, after the temperature in emulsion pot is adjusted to not higher than 45 DEG C, triethanolamine is added, stirs 5min, wood is then added
Sugar alcohol, saccharomycetes to make fermentation lysate filtrate, grape seed extract, glucan, allantoin, panthenol stir evenly, and add 1,
2- hexylene glycol, decoyl hydroximic acid, Sensiva SC50 stir evenly, and moisturizing can be obtained and repair cosmetic composition.
Embodiment 2
Moisturizing is prepared according to preparation method similar to Example 1 and repairs cosmetic composition, the present embodiment and reality
The difference for applying example 1 is that raw material is different, the raw material of the present embodiment 2, in percentage by weight, comprising: carbomer 0.1%, third
Glycol 10%, glycerol 4%, glycine betaine 6%, Sodium Hyaluronate 0.1%, xylitol 1%, saccharomycetes to make fermentation lysate filtrate
13%, grape seed extract 5%, triethanolamine 0.1%, glucan 5%, allantoin 0.2%, panthenol 0.5%, 1,2- hexylene glycol
0.2%, decoyl hydroximic acid 0.05%, Sensiva SC50 0.01%, water surplus.
Embodiment 3
Moisturizing is prepared according to preparation method similar to Example 1 and repairs cosmetic composition, the present embodiment and reality
The difference for applying example 1 is that raw material is different, the raw material of the present embodiment 3, in percentage by weight, comprising: carbomer 0.5%, third
Glycol 5%, glycerol 9%, glycine betaine 2%, Sodium Hyaluronate 0.5%, xylitol 5%, saccharomycetes to make fermentation lysate filtrate
5%, grape seed extract 15%, triethanolamine 0.5%, glucan 2%, allantoin 0.1%, panthenol 2%, 1,2- hexylene glycol
0.8%, decoyl hydroximic acid 0.01%, Sensiva SC50 0.1%, water surplus.
Embodiment 4
Moisturizing is prepared according to preparation method similar to Example 1 and repairs cosmetic composition, the present embodiment and reality
The difference for applying example 1 is that raw material is different, the raw material of the present embodiment 4, in percentage by weight, comprising: carbomer 0.1-1%,
Propylene glycol 1%, glycerol 9%, glycine betaine 7%, Sodium Hyaluronate 0.8%, xylitol 9%, saccharomycetes to make fermentation extract 1%, Portugal
Grape seed extract 2%, triethanolamine 0.1%, glucan 1%, allantoin 0.05%, panthenol 5%, 1,2- hexylene glycol 1%, decoyl
Hydroximic acid 0.01%, Sensiva SC50 0.01%, water surplus.
Embodiment 5
Moisturizing is prepared according to preparation method similar to Example 1 and repairs cosmetic composition, the present embodiment and reality
The difference for applying example 1 is that raw material is different, the raw material of the present embodiment 5, in percentage by weight, comprising: carbomer 0.1%, third
Glycol 1%, glycerol 1%, glycine betaine 8%, Sodium Hyaluronate 1%, xylitol 10%, saccharomycetes to make fermentation extract 20%, grape
Seed extract 2%, triethanolamine 0.1%, Dextran 8 %, allantoin 0.5%, panthenol 5%, 1,2- hexylene glycol 1%, decoyl hydroxyl
Oxime acid 0.1%, Sensiva SC50 0.5%, water surplus.
Embodiment 6
Moisturizing is prepared according to preparation method similar to Example 1 and repairs cosmetic composition, the present embodiment and reality
The difference for applying example 1 is raw material difference, the raw material of the present embodiment 6, in percentage by weight, comprising: carbomer 1%, the third two
Alcohol 10%, glycerol 10%, glycine betaine 1%, Sodium Hyaluronate 0.1%, xylitol 1%, saccharomycetes to make fermentation extract 1%, grape
It is seed extract 20%, triethanolamine 1%, glucan 1%, allantoin 0.05%, panthenol 0.1%, 1,2- hexylene glycol 0.1%, pungent
Acyl hydroximic acid 0.01%, Sensiva SC50 0.01%, water surplus.
Comparative example 1
Guarantor is prepared according to preparation method similar to Example 1 in beneficial effect in order to further illustrate the present invention
Wet reparation cosmetic composition, this comparative example is the difference from embodiment 1 is that raw material is different, the raw material of this comparative example 1, by weight
Percentages, comprising: carbomer 0.3%, propylene glycol 7%, glycerol 6%, glycine betaine 4%, Sodium Hyaluronate 0.3%, xylitol
2%, grape seed extract 10%, triethanolamine 0.3%, glucan 3%, allantoin 0.12%, panthenol 1%, 1,2- hexylene glycol
0.6%, decoyl hydroximic acid 0.02%, Sensiva SC50 0.03%, water surplus.
Comparative example 2
Guarantor is prepared according to preparation method similar to Example 1 in beneficial effect in order to further illustrate the present invention
Wet reparation cosmetic composition, this comparative example is the difference from embodiment 1 is that raw material is different, the raw material of this comparative example 1, by weight
Percentages, comprising: carbomer 0.3%, propylene glycol 7%, glycerol 6%, glycine betaine 4%, Sodium Hyaluronate 0.3%, xylitol
2%, saccharomycetes to make fermentation lysate filtrate 8%, triethanolamine 0.3%, glucan 3%, allantoin 0.12%, panthenol 1%, 1,
2- hexylene glycol 0.6%, decoyl hydroximic acid 0.02%, Sensiva SC50 0.03%, water surplus.
Comparative example 3
Guarantor is prepared according to preparation method similar to Example 1 in beneficial effect in order to further illustrate the present invention
Wet reparation cosmetic composition, this comparative example is the difference from embodiment 1 is that raw material is different, the raw material of this comparative example 1, by weight
Percentages, comprising: carbomer 0.3%, propylene glycol 7%, glycerol 6%, glycine betaine 4%, Sodium Hyaluronate 0.3%, xylitol
2%, saccharomycetes to make fermentation lysate filtrate 8%, grape seed extract 10%, triethanolamine 0.3%, glucan 3%, panthenol
1%, 1,2- hexylene glycol 0.6%, decoyl hydroximic acid 0.02%, Sensiva SC50 0.03%, water surplus.
Effect example
The product and commercially available one pretty one root of Dahurian angelica maintenance essence of Example and comparative example do following clinic as trial product
Test:
According to the ratio of men and women 1:1, selects the age in 18-22 years old volunteer, be divided into 25 people/group；The volunteer of each group uses
After warm water washes one's face, 3g trial product is taken respectively, after thorough cleaning skin, trial product is uniformly applied on skin, aforesaid operations
Once a day, specific grouping is referring to table 1.With the calculating of skin problem (red capillary) position, its skin for repairing 50% quantity is recorded
Problem spent time (that is, averagely repairing the half period), and the healing state in affected part is observed, after skin repair is removed, obtained by calculating
The cure rate that must be repaired.
1 red capillary repairing effect test result of table
Interpretation of result: as the test result in table 1 it is found that cosmetics group is repaired in moisturizing obtained by using Examples 1 to 6
The effect for dispelling red capillary for closing the user of object is significantly better than product and commercially available similar product obtained by comparative example,
In, the Red blood streak dispelling effect that cosmetic composition is repaired in moisturizing obtained by embodiment 1 is best, and the averagely reparation half period is 8 days,
Healing rate reaches 83%, this illustrates that grape seed extract, saccharomycete in cosmetic combinations composition formula are repaired in moisturizing of the invention
Fermentation lysates filtrate and other components have different effect ingredients, have the synergistic effect of complementary collaboration.
Above the embodiments of the present invention are described in detail, but the present invention is not limited to described embodiments.It is right
For those skilled in the art, in the case where not departing from the principle of the invention and spirit, these embodiments are carried out more
Kind change, modification, replacement and modification, still fall in protection scope of the present invention.
Claims (10)
1. cosmetic composition is repaired in a kind of moisturizing, which is characterized in that by weight percentage, comprising: carbomer 0.1-1%,
Propylene glycol 1-10%, glycerol 1-10%, glycine betaine 1-8%, Sodium Hyaluronate 0.1-1%, xylitol 1-10%, saccharomycetes to make fermentation
Extract 1-20%, grape seed extract 2-20%, triethanolamine 0.1-1%, glucan 1-8%, allantoin 0.05-0.5%,
Panthenol 0.1-5%, 1,2- hexylene glycol 0.1-1%, decoyl hydroximic acid 0.01-0.1%, Sensiva SC50 0.01-0.5%, water
Surplus.
2. cosmetic composition is repaired in moisturizing according to claim 1, which is characterized in that cosmetics group is repaired in the moisturizing
Close object, by weight percentage, comprising: carbomer 0.1-0.5%, propylene glycol 5-10%, glycerol 4-9%, glycine betaine 2-6%,
Sodium Hyaluronate 0.1-0.5%, xylitol 1-5%, saccharomycetes to make fermentation extract 5-13%, grape seed extract 5-15%, three
Ethanol amine 0.1-0.5%, glucan 2-5%, allantoin 0.1-0.2%, panthenol 0.5-2%, 1,2- hexylene glycol 0.2-0.8%,
Decoyl hydroximic acid 0.01-0.05%, Sensiva SC50 0.01-0.1%, water surplus.
3. cosmetic composition is repaired in moisturizing according to claim 1, which is characterized in that cosmetics group is repaired in the moisturizing
Object is closed, by weight percentage, comprising: carbomer 0.3%, propylene glycol 7%, glycerol 6%, glycine betaine 4%, Sodium Hyaluronate
0.3%, xylitol 2%, saccharomycetes to make fermentation extract 8%, grape seed extract 10%, triethanolamine 0.3%, glucan 3%,
Allantoin 0.12%, panthenol 1%, 1,2- hexylene glycol 0.6%, decoyl hydroximic acid 0.02%, Sensiva SC50 0.03%, more than water
Amount.
4. cosmetic composition is repaired in moisturizing according to claim 1, which is characterized in that cosmetics group is repaired in the moisturizing
Object is closed, by weight percentage, comprising: carbomer 0.1%, propylene glycol 10%, glycerol 4%, glycine betaine 6%, Sodium Hyaluronate
0.1%, xylitol 1%, saccharomycetes to make fermentation extract 13%, grape seed extract 5%, triethanolamine 0.1%, glucan 5%,
Allantoin 0.2%, panthenol 0.5%, 1,2- hexylene glycol 0.2%, decoyl hydroximic acid 0.05%, Sensiva SC50 0.01%, water
Surplus.
5. cosmetic composition is repaired in moisturizing according to claim 1, which is characterized in that cosmetics group is repaired in the moisturizing
Object is closed, by weight percentage, comprising: carbomer 0.5%, propylene glycol 5%, glycerol 9%, glycine betaine 2%, Sodium Hyaluronate
0.5%, xylitol 5%, saccharomycetes to make fermentation extract 5%, grape seed extract 15%, triethanolamine 0.5%, glucan 2%,
Allantoin 0.1%, panthenol 2%, 1,2- hexylene glycol 0.8%, decoyl hydroximic acid 0.01%, Sensiva SC50 0.1%, more than water
Amount.
6. cosmetic composition is repaired in moisturizing according to claim 1, which is characterized in that the grape seed extract is to adopt
It is made with following methods:
It is the ratio of 1:5~10 according to the w/v mg/ml of the grape pip and solvent, after grape pip and solvent are mixed
2~4h is stirred under conditions of 80-100 DEG C, is collected by filtration to obtain the first filtrate and the first filter residue；According to first filter residue with
The w/v mg/ml of solvent is the ratio of 1:5~10, by the item after first filter residue and solvent mixing at 80-100 DEG C
1~3h is stirred under part, is collected by filtration to obtain the second filtrate and the second filter residue, and first filtrate and second filtrate are mixed
It is concentrated under reduced pressure afterwards and the grape seed extract is made；The solvent is the mixed solution of ethyl alcohol, glycerol and water.
7. cosmetic composition is repaired in moisturizing according to claim 1, which is characterized in that the saccharomycetes to make fermentation extract
For Fermentation in Pichia Pastoris lysis filtrate.
8. cosmetic composition is repaired in moisturizing according to claim 7, which is characterized in that the pichia pastoris yeast hair
Ferment lysis filtrate extracts from the tunning of pichia pastoris yeast.
9. the preparation method of cosmetic composition is repaired in a kind of moisturizing as described in any one of claims 1 to 8, feature exists
In including the following steps:
Water, carbomer, propylene glycol, glycerol, glycine betaine, Sodium Hyaluronate are added and is heated to 85-90 DEG C in emulsion pot and keeps the temperature
20~60min, after the temperature in emulsion pot is adjusted to not higher than 45 DEG C, be added triethanolamine, stir 3~10min, then plus
Enter xylitol, saccharomycetes to make fermentation extract, grape seed extract, glucan, allantoin, panthenol to stir evenly, adds 1,2-
Hexylene glycol, decoyl hydroximic acid, Sensiva SC50 stir evenly, and moisturizing can be obtained and repair cosmetic composition.
10. a kind of moisturizing as described in any one of claims 1 to 8 repairs cosmetic composition and is preparing answering in cosmetics
With.
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Cited By (8)
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| CN110638720A (en) * | 2019-10-29 | 2020-01-03 | 浙江英树生物科技有限公司 | Plant moisturizing and repairing lotion and preparation method thereof |
| CN110755310A (en) * | 2019-11-15 | 2020-02-07 | 上海曜爱生物科技有限公司 | Active composition for promoting skin microcirculation and preparation method and application thereof |
| CN111265470A (en) * | 2020-03-30 | 2020-06-12 | 西安润玉医疗科技有限公司 | Microecological restoration composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110638720A (en) * | 2019-10-29 | 2020-01-03 | 浙江英树生物科技有限公司 | Plant moisturizing and repairing lotion and preparation method thereof |
| CN110638720B (en) * | 2019-10-29 | 2022-06-10 | 浙江英树生物科技有限公司 | Plant moisturizing and repairing lotion and preparation method thereof |
| CN110755310A (en) * | 2019-11-15 | 2020-02-07 | 上海曜爱生物科技有限公司 | Active composition for promoting skin microcirculation and preparation method and application thereof |
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| CN112516027A (en) * | 2020-12-15 | 2021-03-19 | 广州市拉凯尔干细胞研究所 | Fermented skin care composition |
| CN113876616A (en) * | 2021-10-14 | 2022-01-04 | 安徽中美生谷生物科技有限公司 | Skin care composition with wrinkle removing effect and preparation method thereof |
| CN114939086A (en) * | 2022-06-24 | 2022-08-26 | 羽楠(广州)化妆品有限公司 | Oil-free face cream and preparation method thereof |
| CN115227606A (en) * | 2022-07-25 | 2022-10-25 | 维怡美生物科技(广州)有限公司 | Acne-removing composition, application thereof and acne-removing cream and water containing composition |
| CN115887317A (en) * | 2022-11-04 | 2023-04-04 | 上海臻臣化妆品有限公司 | Moisturizing composition and moisturizing liquid for skin |
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Application publication date: 20190322 |