CN109481592A - A kind of selenium peptide improving eyesight nursing antibacterial liquid and preparation method thereof - Google Patents

A kind of selenium peptide improving eyesight nursing antibacterial liquid and preparation method thereof Download PDF

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Publication number
CN109481592A
CN109481592A CN201811618575.4A CN201811618575A CN109481592A CN 109481592 A CN109481592 A CN 109481592A CN 201811618575 A CN201811618575 A CN 201811618575A CN 109481592 A CN109481592 A CN 109481592A
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selenium
rich
antibacterial liquid
added
improving eyesight
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胡飞
胡云龙
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Anhui Pupil Biotechnology Co Ltd
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Anhui Pupil Biotechnology Co Ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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Abstract

The invention discloses a kind of selenium peptide improving eyesight to nurse antibacterial liquid, it is composed of the following raw materials by weight: lutein 0.05-0.1, bear gall powder 1-2, selenium-rich soybean 60-70, wild chrysanthemum 5-7, honeysuckle 10-14, pipewort 2-4, butterflybush flower 3-5, fructus lycii 1-2, selenium-rich antibacterial liquid 80-100, taurine 0.1-0.14, product of the invention has fine effect: clearing heat and detoxicating, it supplements the nutrients, antibacterial bacteriostatic, it cleans antipruritic, it clears liver and improve vision, adjust eye microcirculation, protect cell membrane, it is anti-oxidant, to Escherichia coli, staphylococcus aureus, Candida albicans inhibiting effect, and it is safe to use, the feature of environmental protection is good.

Description

A kind of selenium peptide improving eyesight nursing antibacterial liquid and preparation method thereof
Technical field
The invention belongs to nursing fields, and in particular to a kind of selenium peptide improving eyesight nursing antibacterial liquid and preparation method thereof.
Background technique
With the development of Internet era, the mode of people's work and life is changed correspondingly, more and more with the time of eye, The problems such as eye fatigue over time, dry eyes and astringent eyes, redness, eye-blurred, is following.And eyedrops is exactly most common treatment Or alleviate one of the drug agent of ophthalmic uncomfortable.However, most of eyedrops in the market all contain steroids and bacteriostatic agent (anti-corrosion Agent) etc. substances, bacteriostatic agent (preservative) class eyedrops long-time service can suffer from xerophthalmia, cause eyes rubescent, it is dry and astringent or pain Bitterly, and if the long-time service of steroids eyedrops is excessive it can make one to lead to visual impairment in unconsciously corticosteroid glaucoma, Vision and the visual field receive damage；Also contain antibiotic in the eyedrops having at present, long-time service will appear side effect.
Summary of the invention
In view of the defects and deficiencies of the prior art, the present invention intends to provide a kind of selenium peptide improving eyesight nursing antibacterial liquid and Preparation method.
To achieve the above object, the invention adopts the following technical scheme:
A kind of selenium peptide improving eyesight nursing antibacterial liquid, it is composed of the following raw materials by weight:
Lutein 0.05-0.1, bear gall powder 1-2, selenium-rich soybean 60-70, wild chrysanthemum 5-7, honeysuckle 10-14, pipewort 2- 4, butterflybush flower 3-5, fructus lycii 1-2, selenium-rich antibacterial liquid 80-100, taurine 0.1-0.14.
What the selenium-rich antibacterial liquid was made of the raw material of following weight parts:
Erythrina bark 5-8, toad grass 3-4, glucono-δ-lactone 0.04-0.1, cassia seed 7-10, selenium-rich rice 40-50, Citric acid 2-3, Radix Glycyrrhizae 5-7.
The preparation method of the selenium-rich antibacterial liquid, comprising the following steps:
(1) erythrina bark, citric acid mixing are taken, is added in the deionized water of 55-60 times of mixture weight, increasing temperature is 60-65 DEG C, insulated and stirred 1-2 hours, be added selenium-rich rice, continue increase temperature be 75-80 DEG C, insulated and stirred 30-40 minutes, Filtering, obtains filtrate a；
(2) toad grass, Radix Glycyrrhizae, cassia seed mixing are taken, is added in the n-hexane of 10-12 times of mixture weight, increases temperature Degree is 50-60 DEG C, and insulated and stirred 50-60 minutes, filtering obtained extracting solution；
(3) take above-mentioned filtrate a, extracting solution mixing, be added glucono-δ-lactone, stir evenly, be distilled off just oneself Alkane is to get the selenium-rich antibacterial liquid.
A kind of preparation method of selenium peptide improving eyesight nursing antibacterial liquid, comprising the following steps:
(1) selenium-rich soybean, wild chrysanthemum, honeysuckle, pipewort, butterflybush flower, fructus lycii mixing are taken, mixture weight is added to In 90-100 times of deionized water, insulated and stirred 1-2 hours at 60-65 DEG C, filtering obtains filtrate b；
(2) taurine is taken, is added in above-mentioned filtrate b, stirs evenly, the protease of mixture weight 2-3% is added, is risen High-temperature is 35-40 DEG C, keeps the temperature 13-15 hours, and increasing temperature is 90-100 DEG C, and enzyme deactivation 10-15 minutes, it is molten to obtain selenium-rich polypeptide Liquid；
(3) take above-mentioned selenium-rich antibacterial liquid, mixed with lutein, bear gall powder, it is 20-30 minutes ultrasonic, homogeneous, sterilizing to get Antibacterial liquid is nursed in the selenium peptide improving eyesight.
Advantages of the present invention:
The selenium-rich antibacterial liquid that the present invention is added can be mentioned effectively using erythrina bark, toad grass, cassia seed, Radix Glycyrrhizae as raw material The bacteriostasis property of high finished fluid, and joined plasma selenium, selenium is a kind of non-specificity resistant to hydrogen agent glutathione peroxide in body Change one of the important component of enzyme, and this substance can remove peroxide, free radical in eyes, make a cell from damage； The present invention is using selenium-rich soybean as raw material, after Protease Treatment, obtains selenium-rich polypeptide solution, has and repairs well, is anti- Eye part skin aging and other effects；
Product of the invention has fine effect: clearing heat and detoxicating, extra-nutrition, antibacterial bacteriostatic, cleaning is antipruritic, it is bright to clear liver Mesh adjusts eye microcirculation, protects cell membrane, anti-oxidant, inhibits to Escherichia coli, staphylococcus aureus, Candida albicans Effect, and it is safe to use, side effect will not occur in long-time service.
Specific embodiment
Embodiment 1
A kind of selenium peptide improving eyesight nursing antibacterial liquid, it is composed of the following raw materials by weight:
Lutein 0.05, bear gall powder 1, selenium-rich soybean 60, wild chrysanthemum 5, honeysuckle 10, pipewort 2, butterflybush flower 3, fructus lycii 1, selenium-rich antibacterial liquid 80, taurine 0.1.
What the selenium-rich antibacterial liquid was made of the raw material of following weight parts:
Erythrina bark 5, toad grass 3, glucono-δ-lactone 0.04, cassia seed 7, selenium-rich rice 40, citric acid 2, Radix Glycyrrhizae 5.
The preparation method of the selenium-rich antibacterial liquid, comprising the following steps:
(1) erythrina bark, citric acid mixing are taken, is added in 55 times of mixture weight of deionized water, increasing temperature is 60 DEG C, insulated and stirred 1 hour, selenium-rich rice is added, continues to increase temperature to be 75 DEG C, insulated and stirred 30 minutes, filtering obtained filtrate a；
(2) toad grass, Radix Glycyrrhizae, cassia seed mixing are taken, is added in 10 times of mixture weight of n-hexane, increasing temperature is 50 DEG C, insulated and stirred 50 minutes, filtering obtained extracting solution；
(3) take above-mentioned filtrate a, extracting solution mixing, be added glucono-δ-lactone, stir evenly, be distilled off just oneself Alkane is to get the selenium-rich antibacterial liquid.
A kind of preparation method of selenium peptide improving eyesight nursing antibacterial liquid, comprising the following steps:
(1) selenium-rich soybean, wild chrysanthemum, honeysuckle, pipewort, butterflybush flower, fructus lycii mixing are taken, mixture weight is added to In 90 times of deionized water, insulated and stirred 1 hour at 60 DEG C, filtering obtains filtrate b；
(2) taurine is taken, is added in above-mentioned filtrate b, stirs evenly, the protease of mixture weight 2% is added, is increased Temperature is 35 DEG C, keeps the temperature 13 hours, and increasing temperature is 90 DEG C, enzyme deactivation 10 minutes, obtains selenium-rich polypeptide solution；
(3) above-mentioned selenium-rich antibacterial liquid is taken, is mixed with lutein, bear gall powder, ultrasound 20 minutes, homogeneous, sterilizing are to get described Antibacterial liquid is nursed in selenium peptide improving eyesight.
Embodiment 2
A kind of selenium peptide improving eyesight nursing antibacterial liquid, it is composed of the following raw materials by weight:
Lutein 0.1, bear gall powder 2, selenium-rich soybean 70, wild chrysanthemum 7, honeysuckle 14, pipewort 4, butterflybush flower 5, fructus lycii 2, selenium-rich antibacterial liquid 100, taurine 0.14.
What the selenium-rich antibacterial liquid was made of the raw material of following weight parts:
Erythrina bark 8, toad grass 4, glucono-δ-lactone 0.1, cassia seed 10, selenium-rich rice 50, citric acid 2-3, Radix Glycyrrhizae 7。
The preparation method of the selenium-rich antibacterial liquid, comprising the following steps:
(1) erythrina bark, citric acid mixing are taken, is added in 60 times of mixture weight of deionized water, increasing temperature is 65 DEG C, insulated and stirred 2 hours, selenium-rich rice is added, continues to increase temperature to be 80 DEG C, insulated and stirred 40 minutes, filtering obtained filtrate a；
(2) toad grass, Radix Glycyrrhizae, cassia seed mixing are taken, is added in 12 times of mixture weight of n-hexane, increasing temperature is 60 DEG C, insulated and stirred 60 minutes, filtering obtained extracting solution；
(3) take above-mentioned filtrate a, extracting solution mixing, be added glucono-δ-lactone, stir evenly, be distilled off just oneself Alkane is to get the selenium-rich antibacterial liquid.
A kind of preparation method of selenium peptide improving eyesight nursing antibacterial liquid, comprising the following steps:
(1) selenium-rich soybean, wild chrysanthemum, honeysuckle, pipewort, butterflybush flower, fructus lycii mixing are taken, mixture weight is added to In 100 times of deionized water, insulated and stirred 2 hours at 65 DEG C, filtering obtains filtrate b；
(2) taurine is taken, is added in above-mentioned filtrate b, stirs evenly, the protease of mixture weight 3% is added, is increased Temperature is 40 DEG C, keeps the temperature 15 hours, and increasing temperature is 100 DEG C, enzyme deactivation 15 minutes, obtains selenium-rich polypeptide solution；
(3) above-mentioned selenium-rich antibacterial liquid is taken, is mixed with lutein, bear gall powder, ultrasound 30 minutes, homogeneous, sterilizing are to get described Antibacterial liquid is nursed in selenium peptide improving eyesight.
The application method of product of the present invention:
1. cup sterilizes；
2. should remove ornaments and formal dress before use, face cleaning, cleaning eye circumference；
3. selenium peptide improving eyesight nursing antibacterial liquid of the invention is poured into cup 5 milliliters；
4. bowing, cup is faced outwardly greatly, cup is squeezed, periocualr skin is close at edge, comes back after being sucked cup is low Portion is upward；
5. opening, eyeball is seen up and down, and turn left circle, and circle of turning right cleans 3 minutes or so repeatedly；
6. outwelling collyrium after washed, after cup disinfection, then same method washes another eye.
Clinical observation
The present invention carries out clinical observation treatment to 100 patients so far in October, 2017, differs within the age 10-60 years old；
The symptoms such as therapeutic effect: achieving positive effect, and eye is dry, eye is puckery, red and swollen, eye is itched disappear, and persistently with Patient in track treatment does not generate the corticosteroid glaucoma for leading to be possible to initiation because eyedrops is used for a long time, under eyesight The problems such as drop, vision and the visual field are damaged.

Claims (4)

1. antibacterial liquid is nursed in a kind of selenium peptide improving eyesight, which is characterized in that it is composed of the following raw materials by weight:
It is lutein 0.05-0.1, bear gall powder 1-2, selenium-rich soybean 60-70, wild chrysanthemum 5-7, honeysuckle 10-14, pipewort 2-4, close Cover flower 3-5, fructus lycii 1-2, selenium-rich antibacterial liquid 80-100, taurine 0.1-0.14.
2. antibacterial liquid is nursed in a kind of selenium peptide improving eyesight according to claim 1, which is characterized in that the selenium-rich antibacterial liquid be by The raw material composition of following weight parts:
Erythrina bark 5-8, toad grass 3-4, glucono-δ-lactone 0.04-0.1, cassia seed 7-10, selenium-rich rice 40-50, lemon Sour 2-3, Radix Glycyrrhizae 5-7.
3. antibacterial liquid is nursed in a kind of selenium peptide improving eyesight according to claim 2, which is characterized in that the system of the selenium-rich antibacterial liquid Preparation Method, comprising the following steps:
(1) erythrina bark, citric acid mixing are taken, is added in the deionized water of 55-60 times of mixture weight, raising temperature is 60- 65 DEG C, insulated and stirred 1-2 hours, be added selenium-rich rice, continue increase temperature be 75-80 DEG C, insulated and stirred 30-40 minutes, mistake Filter, obtains filtrate a；
(2) toad grass, Radix Glycyrrhizae, cassia seed mixing are taken, is added in the n-hexane of 10-12 times of mixture weight, increasing temperature is 50-60 DEG C, insulated and stirred 50-60 minutes, filtering obtained extracting solution；
(3) above-mentioned filtrate a, extracting solution mixing are taken, glucono-δ-lactone is added, stirs evenly, n-hexane is distilled off, i.e., Obtain the selenium-rich antibacterial liquid.
4. a kind of preparation method of selenium peptide improving eyesight nursing antibacterial liquid as described in claim 1, which is characterized in that including following step It is rapid:
(1) selenium-rich soybean, wild chrysanthemum, honeysuckle, pipewort, butterflybush flower, fructus lycii mixing are taken, mixture weight 90- is added to In 100 times of deionized water, insulated and stirred 1-2 hours at 60-65 DEG C, filtering obtains filtrate b；
(2) taurine is taken, is added in above-mentioned filtrate b, stirs evenly, the protease of mixture weight 2-3% is added, increases temperature Degree is 35-40 DEG C, keeps the temperature 13-15 hours, and increasing temperature is 90-100 DEG C, enzyme deactivation 10-15 minutes, obtains selenium-rich polypeptide solution；
(3) above-mentioned selenium-rich antibacterial liquid is taken, is mixed with lutein, bear gall powder, 20-30 minutes ultrasonic, homogeneous, sterilizing are to get described Antibacterial liquid is nursed in selenium peptide improving eyesight.
CN201811618575.4A 2018-12-28 2018-12-28 A kind of selenium peptide improving eyesight nursing antibacterial liquid and preparation method thereof Pending CN109481592A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107789617A (en) * 2017-11-16 2018-03-13 北京德尚悦目科技有限公司安徽分公司 A kind of selenium peptide improving eyesight eye refreshing drop and preparation method thereof
WO2018134738A1 (en) * 2017-01-17 2018-07-26 Safenat S.R.L. Compositions based on active principles of plant origin having eye protection action

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018134738A1 (en) * 2017-01-17 2018-07-26 Safenat S.R.L. Compositions based on active principles of plant origin having eye protection action
CN107789617A (en) * 2017-11-16 2018-03-13 北京德尚悦目科技有限公司安徽分公司 A kind of selenium peptide improving eyesight eye refreshing drop and preparation method thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
李峥嵘: "蟾蜍草提取液体外抑菌作用的观察", 《医药与保健》 *
武谦虎: "《常见治疗肝病中药》", 31 January 2014, 中国医药科技出版社 *
王玉玺等: "《当代中医皮肤科临床家丛书》", 31 October 2014, 中国医药科技出版社 *
马洪莲: "《老年人饮食+运动+中医调养全书》", 31 March 2016, 天津科学技术出版社 *

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Application publication date: 20190319