CN117257877B - Traditional Chinese medicine composition for treating xerophthalmia and ophthalmic fumigation lotion - Google Patents
Traditional Chinese medicine composition for treating xerophthalmia and ophthalmic fumigation lotion Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating xerophthalmia and an ophthalmic fumigation lotion. The invention provides a traditional Chinese medicine fumigation lotion containing chrysanthemum, medlar, buddleia, semen celcii, honeysuckle and selfheal, which is used for taking medicines through fumigation and washing, and clinical statistics shows that the traditional Chinese medicine fumigation lotion has obvious curative effect on treating xerophthalmia, and the total effective rate is 91.43 percent, even up to 97.14 percent.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating xerophthalmia and an ophthalmic fumigation lotion.
Background
Dry eye, also called keratoconjunctival dryness, refers to a lacrimal secretion disorder eye disease, which is caused by various factors and is mainly manifested as dry eyes, with symptoms of itching eyes, foreign body sensation, burning sensation, photophobia, blurred vision, and vision fluctuation. Common symptoms include dry eyes, easy tiredness, itching eyes, feeling of foreign body, pain and burning sensation, sticky secretion, fear of wind, photophobia and sensitivity to external stimuli; sometimes the eyes are too dry, the basic tears are insufficient, instead, reflex tear secretion is stimulated, and frequent tearing is caused; the eyes are red, swollen, hyperemic, keratinized, broken and adhered with filiform substances, and the damage can cause keratoconjunctival lesions and affect the eyesight after a long time.
Recent studies have considered that changes in ocular surface, immune-based inflammatory reactions, apoptosis, changes in sex hormone levels, etc. are factors involved in the development and progression of dry eye, and the relationship between the factors is not yet known. The etiology can be divided into the following four categories:
1. Aqueous layer lacrimal gland has insufficient lacrimal secretion. The congenital lachrymal gland, senile decrease of lachrymal gland function or inflammation, trauma, infection and autonomic imbalance of the lachrymal glands caused by some autoimmune diseases, and tear hyposecretion caused by long-term administration of some eye drops or taking some medicines; a person wearing contact lenses for a long period of time.
2. The grease layer is not secreted enough. Meibomian gland dysfunction is caused by eyelid disease.
3. The mucin layer is not secreted enough. Vitamin A1 deficiency, chronic conjunctivitis, chemical burns, etc.
4. The tears are excessively evaporated and the tear film is unevenly distributed. Eyelid diseases cause poor eyelid closure, reduced blink times, and prolonged residence in cold air rooms or outdoor strong wind dryness-heat environments.
The Chinese patent publication No. CN 103041067A discloses a traditional Chinese medicine for treating xerophthalmia, which is a capsule prepared from the following raw materials in parts by weight: 9 parts of glabrous sarcandra herb, 15 parts of monarch, 8 parts of chamomile, 2 parts of saffron, 6 parts of hawthorn seed, 30 parts of pine needle and 8 parts of limonium. But the treatment course is 1 month and the time is long.
Chinese patent publication No. CN102973842A discloses a Chinese medicinal fumigation and washing liquid for treating xerophthalmia. The Chinese medicine fumigation and washing liquid is prepared from groundsel, teff grass, natural indigo, potentilla anserina, herb of common goldthread, red paeony root, obscured homalomena rhizome, cowherb seed, fragrant solomonseal rhizome, glossy privet fruit, south dodder seed and coix seed, and the total effective rate reaches 93.0 percent.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention provides a traditional Chinese medicine composition for treating xerophthalmia and application thereof, wherein the traditional Chinese medicine composition comprises the following components: flos Chrysanthemi, fructus Lycii, flos Buddlejae, semen Celosiae, flos Lonicerae, prunellae Spica, and further comprises radix Berberidis Amurensis and Hirudo.
Specifically, the technical scheme of the invention is as follows:
A first object of the present invention is to provide a Chinese medicinal composition for treating dry eye, which comprises: flos Chrysanthemi, fructus Lycii, flos Buddlejae, semen Celosiae, flos Lonicerae, and Prunellae Spica.
In a plurality of embodiments, the traditional Chinese medicine composition comprises the following components in parts by weight: 1 to 5 parts of chrysanthemum, 3 to 9 parts of medlar, 1 to 5 parts of buddleia officinalis, 2 to 10 parts of box, 1 to 6 parts of honeysuckle and 3 to 10 parts of selfheal.
In a preferred embodiment, the traditional Chinese medicine composition comprises the following components in parts by weight: 3 parts of chrysanthemum, 6 parts of medlar, 3 parts of butterflybush flower, 6 parts of green box, 3 parts of honeysuckle and 6 parts of selfheal.
In various embodiments, the Chinese medicinal composition comprises flos Chrysanthemi, fructus Lycii, flos Buddlejae, semen Celosiae, flos Lonicerae, prunellae Spica, radix Berberidis, and Hirudo.
In a plurality of embodiments, the traditional Chinese medicine composition comprises the following components in parts by weight: 1 to 5 parts of chrysanthemum, 3 to 9 parts of medlar, 1 to 5 parts of butterflybush flower, 2 to 10 parts of box, 1 to 6 parts of honeysuckle, 3 to 10 parts of selfheal, 3 to 9 parts of root of Chinese barberry and 0.5 to 3 parts of leech.
In a preferred embodiment, the traditional Chinese medicine composition comprises the following components in parts by weight: 3 parts of chrysanthemum, 6 parts of medlar, 3 parts of butterflybush flower, 6 parts of green box, 3 parts of honeysuckle, 6 parts of selfheal, 7 parts of barberry and 1 part of leech.
The second object of the invention is to provide an ophthalmic fumigation lotion, which consists of the traditional Chinese medicine composition, pharmaceutically usable auxiliary materials and a carrier.
The third object of the present invention is to provide a preparation method of the above-mentioned ophthalmic fumigation lotion, which comprises the following steps: the preparation method comprises cleaning the raw materials, sterilizing, pulverizing into coarse powder, decocting with sterile water, and making into fumigation lotion.
Experimental results show that the eye fumigation lotion prepared by adding the root of Chinese barberry and the leech in a certain proportion has more excellent effect of treating xerophthalmia.
Further, the above-mentioned ophthalmic fumigation lotion can also be combined with other clinical medicines, such as sodium hyaluronate eye drops, hydroxyl sugar sweet eye drops, cyclosporine A eye drops, levofloxacin eye drops, compound mannitol injection, carbomer eye gel, calf serum deproteinized eye gel, fluorometholone eye drops, typical privates eye drops, cyclosporine eye drops, tacrolimus eye drops, diquafosol eye drops, and the like.
Wherein, the xerophthalmia includes, but is not limited to, hydrojet deficient xerophthalmia, mucin deficient xerophthalmia, lipid deficient xerophthalmia, xerophthalmia caused by abnormal tear dynamics, mixed xerophthalmia.
Compared with the prior art, the invention has the technical effects that:
The invention provides a traditional Chinese medicine fumigation lotion comprising chrysanthemum, medlar, buddleia, semen celcii, honeysuckle and selfheal, which has obvious curative effect on dry eye syndrome, and the total effective rate is 91.43 percent and even up to 97.14 percent through clinical trial statistics.
Drawings
Fig. 1: example 4 an ophthalmic fumigation lotion.
Detailed Description
Example 1 an ophthalmic fumigation lotion
The formula comprises the following components:
3g of chrysanthemum, 6g of medlar, 3g of buddleia officinalis, 6g of semen celtis, 3g of honeysuckle and 6g of selfheal.
The preparation method comprises the following steps:
Weighing the medicinal materials according to the formula, cleaning, sterilizing, crushing into coarse powder, adding sterile water for decoction for 0.5-1.5 h, filtering, and preparing the fumigation lotion.
Example 2 an ophthalmic fumigation lotion
The formula comprises the following components:
1g of chrysanthemum, 3g of medlar, 1g of buddleia officinalis, 2g of semen celtis, 1g of honeysuckle and 3g of selfheal.
The preparation method comprises the following steps:
Weighing the medicinal materials according to the formula, cleaning, sterilizing, crushing into coarse powder, adding sterile water for decoction for 0.5-1.5 h, filtering, and preparing the fumigation lotion.
Example 3 an ophthalmic fumigation lotion
The formula comprises the following components:
Chrysanthemum 5g, medlar 9g, buddleia 5g, semen box 10g, honeysuckle 6g and selfheal 10g.
The preparation method comprises the following steps:
Weighing the medicinal materials according to the formula, cleaning, sterilizing, crushing into coarse powder, adding sterile water for decoction for 0.5-1.5 h, filtering, and preparing the fumigation lotion.
Example 4 an ophthalmic fumigation lotion
The formula comprises the following components:
3g of chrysanthemum, 6g of medlar, 3g of butterflybush flower, 6g of semen box, 3g of honeysuckle, 6g of selfheal, 7g of radix berberidis and 1g of leech.
The preparation method comprises the following steps:
Weighing the medicinal materials according to the formula, cleaning, sterilizing, crushing into coarse powder, adding sterile water for decoction for 0.5-1.5 h, filtering, and preparing the fumigation lotion.
Example 5 an ophthalmic fumigation lotion
The formula comprises the following components:
1g of chrysanthemum, 3g of medlar, 1g of buddleia officinalis, 2g of semen box, 1g of honeysuckle, 3g of selfheal, 3g of radix berberidis and 0.5g of leech.
The preparation method comprises the following steps:
Weighing the medicinal materials according to the formula, cleaning, sterilizing, crushing into coarse powder, adding sterile water for decoction for 0.5-1.5 h, filtering, and preparing the fumigation lotion.
Example 6 an ophthalmic fumigation lotion
The formula comprises the following components:
5g of chrysanthemum, 9g of medlar, 5g of buddleia officinalis, 10g of semen box, 6g of honeysuckle, 10g of selfheal, 9g of radix berberidis and 3g of leech.
The preparation method comprises the following steps:
Weighing the medicinal materials according to the formula, cleaning, sterilizing, crushing into coarse powder, adding sterile water for decoction for 0.5-1.5 h, filtering, and preparing the fumigation lotion.
Comparative example 1 an ophthalmic fumigation lotion
The formula comprises the following components:
3g of chrysanthemum, 6g of medlar, 3g of buddleja officinalis, 6g of semen box, 3g of honeysuckle, 6g of selfheal and 1g of root of Chinese barberry.
The preparation method comprises the following steps:
Weighing the medicinal materials according to the formula, cleaning, sterilizing, crushing into coarse powder, adding sterile water for decoction for 0.5-1.5 h, filtering, and preparing the fumigation lotion.
Comparative example 2 an ophthalmic fumigation lotion
The formula comprises the following components:
3g of chrysanthemum, 6g of medlar, 3g of butterflybush flower, 6g of semen celtis, 3g of honeysuckle, 6g of selfheal and 3g of leech.
The preparation method comprises the following steps:
Weighing the medicinal materials according to the formula, cleaning, sterilizing, crushing into coarse powder, adding sterile water for decoction for 0.5-1.5 h, filtering, and preparing the fumigation lotion.
Clinical data
1. General data
140 Patients (280 eyes) diagnosed with dry eye by the Jinan traditional Chinese medical hospital in 2021, 5 months to 2023, 5 months were screened and randomly divided into example 1, example 4, comparative example 1 and comparative example 2.
Example 1 group: 35 patients (70 eyes), of which 12 men (24 eyes) and 23 women (46 eyes) were aged at an average age (46.52 + -5.27) and an average course (18.05+ -4.74) for months.
Example 4 group: 35 patients (70 eyes), 14 men (28 eyes), 21 women (42 eyes), average age (44.32 + -4.87) years, average course (18.64+ -5.09) months.
Comparative example 1 group: 35 patients (70 eyes), 15 men (30 eyes), 20 women (40 eyes), average age (43.24 + -5.02) years, average course (19.05+ -4.93) months.
Comparative example 2 group: 35 patients (70 eyes), 16 men (32 eyes), 19 women (38 eyes), average age (47.01 + -4.68) years, average course (18.82+ -4.70) months.
The general data of the four groups of patients are compared, and the differences have no statistical significance (P is more than 0.05) and are comparable.
2 Inclusion criteria and exclusion criteria
2.1 Inclusion criteria:
(1) Meets the diagnostic criteria of traditional Chinese medicine (subjective symptoms such as dry feeling, foreign body sensation, asthenopia, photophobia, burning sensation, eye pain sensation, lacrimation, and redness of eyes; tongue and pulse condition such as red or yellow tongue, thin and weak pulse or soft and rapid pulse);
(2) Patients aged 18-62 years can be included in the subject, and the sex is unlimited;
(3) Other medications have been used, but have been discontinued for more than 2 weeks;
(4) Informed consent.
The person meeting the above conditions can be given access.
2.2 Exclusion criteria:
(1) Those with other conjunctiva, cornea, and iris lesions evident;
(2) Pregnant or lactating women;
(3) Allergic or intolerant to the drug used and not according to the prescribed drug;
(4) Patients with severe primary diseases and psychosis such as severe barycenter, cerebral vessels, liver, kidney, and hematopoietic system are combined.
(5) In patients who participated in other drug clinical trials.
3. Therapeutic method
Example 1 group of fumigation lotion prepared in example 1 of the present invention fumigates eyes with heating steam on the top surface, washes eyes after the decoction cools, and takes 14 days as a treatment course.
Example 4 group of fumigation lotion prepared in example 4 of the present invention, the eyes were fumigated with heating steam on the top surface, and after the decoction cooled, the eyes were rinsed twice daily, 14 days being a treatment course.
Comparative example 1 group the fumigation lotion prepared in comparative example 1 of the present invention fumigates eyes with heating steam on the stomach, washes eyes after the decoction is cooled, and takes 14 days as a course of treatment.
Comparative example 2 group the fumigation lotion prepared in comparative example 2 of the present invention fumigates eyes with heating steam on the stomach, washes eyes after the decoction is cooled, and takes 14 days as a course of treatment.
4. Viewing items
The curative effect standard refers to the traditional Chinese medicine disease diagnosis curative effect standard issued by the Ministry of health, and clinical symptoms, s|T secretion amount, BUT and FL are used as observation indexes.
The effect is shown: symptoms disappeared, s|T secretion was measured multiple times >10mm/5min, BUT <10S, FL staining decreased.
The method is effective: symptoms are relieved, the secretion amount of S|T is increased by multiple measurement, BUT is prolonged earlier, and FL coloration is reduced.
Invalidation: there was no improvement in symptoms, no increase in s|t secretion was measured multiple times, no change in BUT no change in coloration of FL.
5. Results statistics
Table 1 statistics of treatment effects for each group
| Group of | Has obvious effect | Effective and effective | Invalidation of | Total effective rate (%) |
| Example 1 group | 27 | 5 | 3 | 91.43 |
| Example 4 group | 30 | 4 | 1 | 97.14 |
| Comparative example 1 group | 19 | 8 | 8 | 77.14 |
| Comparative example 4 group | 22 | 7 | 6 | 82.85 |
The total effective rate of the patients in the group of the example 1 is 91.43%, the total effective rate of the patients in the group of the example 4 is 97.14%, the treatment effective rate of the patients in the group of the comparative example 1 and the group of the comparative example 2 is obviously improved, and the difference is significant (P < 0.05) when the group of the comparative example 1 and the group of the comparative example 2 are respectively compared with the group of the example 1 and the group of the example 2.
Claims (5)
1. The traditional Chinese medicine composition for treating xerophthalmia is characterized by comprising the following traditional Chinese medicine components: 1-5 parts of chrysanthemum, 3-9 parts of medlar, 1-5 parts of butterflybush flower, 2-10 parts of box, 1-6 parts of honeysuckle, 3-10 parts of selfheal, 3-9 parts of root of Chinese barberry and 0.5-3 parts of leech.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is composed of the following traditional Chinese medicine components: 3 parts of chrysanthemum, 6 parts of medlar, 3 parts of butterflybush flower, 6 parts of green box, 3 parts of honeysuckle, 6 parts of selfheal, 7 parts of barberry and 1 part of leech.
3. An ophthalmic fumigation lotion, which is characterized by comprising the traditional Chinese medicine composition of claim 1, pharmaceutically usable auxiliary materials and carriers.
4. A method of preparing the ophthalmic fumigation lotion of claim 3, said method comprising: the preparation method comprises cleaning the raw materials, sterilizing, pulverizing into coarse powder, decocting with sterile water, and making into fumigation lotion.
5. The traditional Chinese medicine composition according to claim 1, wherein the dry eye comprises: aqueous fluid-deficient dry eye, mucin-deficient dry eye, lipid-deficient dry eye, dry eye due to abnormal tear dynamics, and mixed dry eye.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768283A (en) * | 2014-02-11 | 2014-05-07 | 高会玲 | Traditional Chinese medicine for treating multiple eye diseases |
| CN105288496A (en) * | 2015-12-01 | 2016-02-03 | 袁显兰 | Traditional Chinese medicine composition for curing dry eye |
| CN112807414A (en) * | 2021-01-12 | 2021-05-18 | 辛士义 | Eyesight improving powder for relieving asthenopia and improving eyesight |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103768283A (en) * | 2014-02-11 | 2014-05-07 | 高会玲 | Traditional Chinese medicine for treating multiple eye diseases |
| CN105288496A (en) * | 2015-12-01 | 2016-02-03 | 袁显兰 | Traditional Chinese medicine composition for curing dry eye |
| CN112807414A (en) * | 2021-01-12 | 2021-05-18 | 辛士义 | Eyesight improving powder for relieving asthenopia and improving eyesight |
Non-Patent Citations (1)
| Title |
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| 芪明颗粒治疗2型糖尿病患者干眼症的临床观察;王锋;;中国社区医师(医学专业);20120715(第20期);206，207 * |
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