CN109481590A - 一种药物组合物、静心汤及其制备方法 - Google Patents

一种药物组合物、静心汤及其制备方法 Download PDF

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CN109481590A
CN109481590A CN201811481079.9A CN201811481079A CN109481590A CN 109481590 A CN109481590 A CN 109481590A CN 201811481079 A CN201811481079 A CN 201811481079A CN 109481590 A CN109481590 A CN 109481590A
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冯立军
叶长明
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Lingshen Biotechnology (dalian) Co Ltd
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Abstract

本发明公开了一种药物组合物，包括如下重量份的组分：酸枣仁10～20份、茯苓10～20份、莲子5～15份、甘草1～6份、菊花2～10份、百合5～15份、人参1‑5份、小麦5～15份、大枣10～30份、鸡内金2～6份、薄荷2～6份、黄精2～10份、桑葚2～10份、和牡蛎2～10份。本发明还公开了上述药物组合物水煎而成的静心汤及其制备方法。本发明所述的药物组合物及静心汤可用于抑郁症、焦虑症和失眠症的辅助治疗。静心宁神、改善睡眠、疏肝理气，清热解郁，通络，缓解脏燥，平顺气血，缓解忧虑思愁所致阴血耗损，神不守舒，血不养心，面色苍白，形体消瘦，头晕耳鸣，体倦神疲，心烦多梦。

Description

一种药物组合物、静心汤及其制备方法
技术领域
本发明涉及一种药物组合物及该药物组合物制成的汤剂，具体涉及一种药物组合物、静心汤及其制备方法。
背景技术
目前，抑郁症是全球第四大疾病，大约有七分之一的人会在人生的某个阶段遭受抑郁症的困扰。在中国，抑郁症的发病率约为6％，目前已确诊患抑郁症的患者为3000万左右。专家认为，抑郁症的主要原因来自四个方面：遗传因素、体质因素、生物学因素以及社会心理因素。由于工作压力大、竞争激烈、社会矛盾增多等原因，导致抑郁症患者数量呈明显上升趋势。抑郁症患者通常感觉心情郁闷痛苦，难以集中精力和正常思维，焦虑或坐立不安，还经常伴有身体不适，如胸闷、气短、失眠、多汗、肌肉疼痛等。躯体症状是抑郁症障碍的显著特征，很多早期抑郁症患者往往以躯体症状为主。这些躯体症状长期得不到有效治疗可能会诱发心血管疾病，并形成恶性循环。而靠西药来控制病情则对患者的身体产生一定副作用。
发明内容
本发明针对以上问题的提出，而研究设计一种药物组合物、静心汤及其制备方法。本发明采用的技术手段如下：
一种药物组合物，包括如下重量份的组分：酸枣仁10～20份、茯苓10～20份、莲子5～15份、甘草1～6份、菊花2～10份、百合5～15份、人参1-5份、小麦5～15份、大枣10～30份、鸡内金2～6份、薄荷2～6份、黄精2～10份、桑葚2～10份、和牡蛎2～10份。
进一步地，包括如下重量份的组分：酸枣仁12～18份、茯苓12～18份、莲子8～13份、甘草2～5份、菊花3～8份、百合8～12份、人参2-3份、小麦8～12份、大枣15～25份、鸡内金2～4份、薄荷2～4份、黄精3～8份、桑葚3～8份和牡蛎3～8份。
进一步地，包括如下重量份的组分：酸枣仁15份、茯苓15份、莲子10份、甘草4份、菊花6份、百合10份、人参2份、小麦10份、大枣20份、鸡内金3份、薄荷3份、黄精6份、桑葚5份和牡蛎5份。
一种静心汤，为本发明所述的任意一种药物组合物的水煎提取物。
一种本发明所述的静心汤的制备方法，为水煎提取法，包括以下步骤：
a.一次提取：将药物组合物和水以重量比为1：(8～15)的比例混合提取，提取时间为1～3小时；
b.二次提取：将步骤a剩余的药渣与药物组合物原始重量6～15倍的水混合提取，提取时间为1～3小时。
进一步地，步骤a中水的重量为药物组合物重量的12倍，步骤b中水的重量为药物组合物原始重量的10倍，水煎的压力条件为在一个大气压基础上加压1.5kPa～2kPa。
进一步地，所述制备方法还包括灌装和杀菌步骤。
与现有技术比较，本发明所述的药物组合物及静心汤可用于抑郁症、焦虑症和失眠症的辅助治疗。静心宁神、改善睡眠、疏肝理气，清热解郁，通络，缓解脏燥，平顺气血，缓解忧虑思愁所致阴血耗损，神不守舒，血不养心，面色苍白，形体消瘦，头晕耳鸣，体倦神疲，心烦多梦，采用药食同源的原料，无副作用。
具体实施方式
本发明的所述的药物组合物的实施例如下表所示，单位：克。
一种本发明所述的静心汤的制备方法，为水煎提取法，包括以下步骤：
a.一次提取：将药物组合物和水以重量比为1：(8～15)的比例混合提取，优选药物组合物和水以重量比为1:12，提取时间为1～3小时，优选1小时；
b.二次提取：将步骤a剩余的药渣与药物组合物原始重量6～15倍的水混合提取，优选水的重量为药物组合物原始重量的10倍，提取时间为1～3小时，优选1小时。
本实施例中，水煎的压力条件为在一个大气压基础上加压1.5kPa～2kPa。所述元气恢复汤的制备方法还包括灌装和杀菌步骤，还包括急冻锁鲜工序，所述急冻锁鲜为将提取物在-35℃以下进行冷冻，实现快速冷冻的效果，本实施例优选冷冻温度为-40℃～-35℃。
本实施例经50名不同年龄的人试验，效果显著，下面列举几个典型实例：
1、王某，男，32岁，软件工程师，经常性失眠，精神焦虑，白天伴有胸闷气短等症状，服用实施例一所述的静心汤一周后症状明显缓解。
2、常某某，女，24岁，学生，体倦神疲，心烦多梦，难以集中注意力，服用实施例而所述的静心汤一周后症状基本消失。
3、李某某，男，52岁，自由职业，面色苍白，形体消瘦，头晕耳鸣，经常性失眠，服用实施例三所述的静心汤一周后症状明显缓解。
4、张某某，女，45岁，公司高管，经常性失眠，精神焦虑，白天伴有胸闷气短等症状，服用实施例四所述的静心汤一周后症状明显缓解。
5、严某某，男，29岁，工程师，长期情绪低迷，胸闷乏力，失眠多梦，形体消瘦，服用实施例五所述的静心汤一周后症状明显缓解。
以上所述的实施例仅仅是对本发明的优选实施方式进行描述，并非对本发明的范围进行限定，在不脱离本发明设计精神的前提下，本领域普通技术人员对本发明的技术方案做出的各种变形和改进，均应落入本发明权利要求书确定的保护范围内。

Claims (7)

1.一种药物组合物，包括如下重量份的组分：酸枣仁10～20份、茯苓10～20份、莲子5～15份、甘草1～6份、菊花2～10份、百合5～15份、人参1-5份、小麦5～15份、大枣10～30份、鸡内金2～6份、薄荷2～6份、黄精2～10份、桑葚2～10份、和牡蛎2～10份。
2.根据权利要求1所述的药物组合物，其特征在于：包括如下重量份的组分：酸枣仁12～18份、茯苓12～18份、莲子8～13份、甘草2～5份、菊花3～8份、百合8～12份、人参2-3份、小麦8～12份、大枣15～25份、鸡内金2～4份、薄荷2～4份、黄精3～8份、桑葚3～8份和牡蛎3～8份。
3.根据权利要求2所述的药物组合物，其特征在于：包括如下重量份的组分：酸枣仁15份、茯苓15份、莲子10份、甘草4份、菊花6份、百合10份、人参2份、小麦10份、大枣20份、鸡内金3份、薄荷3份、黄精6份、桑葚5份和牡蛎5份。
4.一种静心汤，为权利要求1至3中所述的任意一种药物组合物的水煎提取物。
5.一种权利要求4所述的静心汤的制备方法，为水煎提取法，包括以下步骤：
a.一次提取：将药物组合物和水以重量比为1：(8～15)的比例混合提取，提取时间为1～3小时；
b.二次提取：将步骤a剩余的药渣与药物组合物原始重量6～15倍的水混合提取，提取时间为1～3小时。
6.根据权利要求5所述的静心汤的制备方法，其特征在于：步骤a中水的重量为药物组合物重量的12倍，步骤b中水的重量为药物组合物原始重量的10倍，水煎的压力条件为在一个大气压基础上加压1.5kPa～2kPa。
7.根据权利要求6所述的静心汤的制备方法，其特征在于：还包括灌装和杀菌步骤。
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