CN109481525A - A kind of dietotherapy hair growth composition - Google Patents
A kind of dietotherapy hair growth composition Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A61K31/07—Retinol compounds, e.g. vitamin A
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
Abstract
This application discloses a kind of dietotherapy hair growth compositions, by mass, which includes following components: 2.5 ~ 4.0 parts of tangshenosides shown in formula I, 1.2 ~ 1.8 parts of aurantiins, 0.3 ~ 0.5 part of vitamin A, 4.5 ~ 5.2 parts of prunella asiatica polysaccharide and 0.8 ~ 1.1 portion of lemon juice；Has the advantages that hair tonic.
Description
Technical field
The present invention relates to a kind of dietotherapy hair growth compositions.
Background technique
Hair is the one of the important signs that of human health, and alopecia is common cutaneous diseases, it is characterized in that epilation
It reduces, is a kind of clinical multiple disease, and be one of refractory disease.Alopecia is likely to occur in all age group,
Its clinical manifestation is that scalp portion round patch shape alopecia, and sharpness of border can occur suddenly, and without other subjective symptoms, severe is de-
Hair patient is also possible to can whole alopecia or general alopecia.It has been generally acknowledged that this disease will not threaten to life, but its easy recurrent exerbation, twine
It is continuous refractory, there is serious influence to the external beauty of patient, great mental suffering and psychological burden are also aggravated therewith in patient
With.
Therefore developing a kind of product for improving hair-growing, there is certain production application to be worth.
Summary of the invention
The object of the present invention is to provide a kind of preparation methods of dietotherapy hair growth composition, have the advantages that hair tonic.
Above-mentioned technical purpose of the invention has the technical scheme that
A kind of dietotherapy hair growth composition, by mass, including following components: 2.5 ~ 4.0 parts of tangshenosides shown in formula I, 1.2 ~
1.8 parts of aurantiins, 0.3 ~ 0.5 part of vitamin A, 4.5 ~ 5.2 parts of prunella asiatica polysaccharide and 0.8 ~ 1.1 portion of lemon juice；
(I)。
Further preferably are as follows: further include following components by mass: 1.5 ~ 2.0 parts of sorbierites, 4.5 ~ 6.0 parts of stearic acid
Magnesium, 0.5 ~ 0.8 part of xanthan gum, 0.5 ~ 0.8 part of citric acid and 0.5 ~ 0.8 part of sodium bicarbonate；One is coated with outside the sodium bicarbonate
The mass ratio of layer polyethylene glycol 2000, the sodium bicarbonate and polyethylene glycol 2000 is 1:0.15 ~ 0.22.
Further preferably are as follows: a kind of dietotherapy hair growth composition is tablet, is prepared by the following method: in fluidized bed
On, polyethylene glycol 2000 aqueous solution is sprayed on outside nanoscale sodium bicarbonate and is dried；By tangshenoside shown in formula I, aurantiin,
Vitamin A, prunella asiatica polysaccharide, lemon juice, sorbierite, magnesium stearate and citric acid are crushed and are sieved respectively, be added xanthan gum and
It is coated with the sodium bicarbonate of polyethylene glycol 2000, it is tabletted after mixing.
Further preferably are as follows: by mass, including following components: 3.2 parts of tangshenosides shown in formula I, 1.5 parts of shaddock peds
Glycosides, 0.4 part of vitamin A, 5.0 parts of prunella asiatica polysaccharide, 1.0 portions of lemon juices, 1.8 parts of sorbierites, 5.0 parts of magnesium stearates, 0.6 part of Huang
Virgin rubber, 0.6 part of citric acid and 0.6 part of sodium bicarbonate；One layer of polyethylene glycol 2000, the carbonic acid are coated with outside the sodium bicarbonate
The mass ratio of hydrogen sodium and polyethylene glycol 2000 is 1:0.20.
Further preferably are as follows: by mass, including following components: 3.2 parts of tangshenosides shown in formula I, 1.5 parts of shaddock peds
What glycosides, 0.4 part of vitamin A, 5.0 parts of prunella asiatica polysaccharide, 1.0 portions of lemon juices, 5.0 parts of black sesame powders fried and 5.0 parts steam
Radix polygoni multiflori powder.
Further preferably are as follows: tangshenoside the preparation method comprises the following steps: (1) dry Radix Codonopsis and crush shown in formula I adds water, add
Heat is added ethyl alcohol, stands 50 ~ 70min after stirring 20 ~ 40min, cross and filter out admittedly to 4 ~ 6hr of refluxing extraction after being cooled to 20 ~ 30 DEG C
Body, filtrate are concentrated into the 1/3 ~ 2/3 of original volume at 35 ~ 42 DEG C, obtain water extract；The mass ratio of dry Radix Codonopsis and water is
The volume ratio of 1:6 ~ 10, water and ethyl alcohol is 1:0.8 ~ 1.1；(2) water intaking extract, is added niacinamide and sodium bicarbonate, and stirring is anti-
20 ~ 40min is answered, solid is filtered to take, is dried at 40 ~ 50 DEG C；The mass ratio of water extract, niacinamide and sodium bicarbonate is 1:
0.05~0.07:0.04~0.06；(3) solid after drying is put into the acetum of 0.5 ~ 0.8wt%, it is stirred to react 20 ~
40min adds ethyl alcohol and is stirred to react 20 ~ 40min, crosses and filters out solid, filtrate is concentrated at 35 ~ 42 DEG C and eliminates solvent, obtains powder
End；The mass ratio of solid and acetum after drying is 1:7 ~ 9, and the volume ratio of acetum and ethyl alcohol is 1:0.5 ~ 0.8；
Aurantiin the preparation method comprises the following steps: (1) dry rhizome of davallia and crush, add ethyl alcohol, be heated to 2 ~ 4hr of refluxing extraction, be cooled to
Ether is added after 20 ~ 30 DEG C, stands 50 ~ 70min after stirring 20 ~ 40min, crosses and filter out solid, filtrate is concentrated at 35 ~ 42 DEG C
The 1/3 ~ 2/3 of original volume, obtains alcohol extracting thing；The mass ratio of the dry rhizome of davallia and ethyl alcohol is 1:4 ~ 6, the body of ethyl alcohol and ether
Product is than being 1:0.3 ~ 0.5；(2) alcohol extracting thing is taken, carboxymethyl chitosan and sodium carbonate is added, is stirred to react 20 ~ 40min, is filtered
Solid is taken, is dried at 40 ~ 50 DEG C；The mass ratio of alcohol extracting thing, carboxymethyl chitosan and sodium carbonate is 1:0.04 ~ 0.06:
0.01~0.03；(3) solid after drying is put into the acetum of 0.5 ~ 0.8wt%, is stirred to react 20 ~ 40min, added diethyl ether
And it is stirred to react 20 ~ 40min, it crosses and filters out solid, filtrate is concentrated at 35 ~ 42 DEG C and eliminates solvent, obtains powder；Consolidating after drying
The mass ratio of body and acetum is 1:4 ~ 6, and the volume ratio of acetum and ether is 1:0.2 ~ 0.4；
Prunella asiatica polysaccharide the preparation method comprises the following steps: (1) dry prunella asiatica and crush, add the acetum of 0.5 ~ 0.8wt%, be heated to
Ethyl alcohol is added in 1 ~ 3hr of refluxing extraction after being cooled to 20 ~ 30 DEG C, stand 50 ~ 70min after stirring 20 ~ 40min, cross and filter out solid,
Filtrate is concentrated to get grease at 35 ~ 42 DEG C；The mass ratio of dry prunella asiatica and acetum is 1:4 ~ 6, acetum
Volume ratio with ethyl alcohol is 1:2.3 ~ 2.7；(2) grease is taken, P123 type PEO-PPO-PEO triblock copolymer, ethyl alcohol is added
And water, it is stirred to react 20 ~ 40min, filters to take solid, is dried at 40 ~ 50 DEG C；Grease, P123 type PEO-PPO-PEO tri- are embedding
Section copolymer, second alcohol and water mass ratio be 1:0.02 ~ 0.04:3 ~ 5:6 ~ 10.
Further preferably are as follows: tangshenoside the preparation method comprises the following steps: (1) dry Radix Codonopsis and crush shown in formula I adds water, add
Heat is added ethyl alcohol, stands 60min after stirring 30min, cross and filter out solid, filtrate is 40 to refluxing extraction 5hr after being cooled to 25 DEG C
It is concentrated into the 1/2 of original volume at DEG C, obtains water extract；The mass ratio of dry Radix Codonopsis and water is 1:8, the volume of water and ethyl alcohol
Than for 1:1.0；(2) water intaking extract is added niacinamide and sodium bicarbonate, is stirred to react 30min, filters to take solid, at 45 DEG C
Lower drying；The mass ratio of water extract, niacinamide and sodium bicarbonate is 1:0.06:0.05；(3) solid after drying is put into
In the acetum of 0.6wt%, it is stirred to react 30min, add ethyl alcohol and is stirred to react 30min, crosses and filters out solid, filtrate is at 40 DEG C
Lower concentration eliminates solvent, obtains powder；The mass ratio of solid and acetum after drying is 1:8, acetum and ethyl alcohol
Volume ratio is 1:0.6；
Aurantiin the preparation method comprises the following steps: (1) dry rhizome of davallia and crush, add ethyl alcohol, be heated to refluxing extraction 3hr, be cooled to 25
Ether is added after DEG C, stands 60min after stirring 30min, crosses and filter out solid, filtrate is concentrated into the 1/2 of original volume at 40 DEG C, obtains
To alcohol extracting thing；The mass ratio of the dry rhizome of davallia and ethyl alcohol is 1:5, and the volume ratio of ethyl alcohol and ether is 1:0.4；(2) alcohol is taken
Extract is added carboxymethyl chitosan and sodium carbonate, is stirred to react 30min, filters to take solid, dry at 45 DEG C；Alcohol extracting
The mass ratio of object, carboxymethyl chitosan and sodium carbonate is 1:0.05:0.02；(3) solid after drying is put into the vinegar of 0.6wt%
In acid solution, it is stirred to react 30min, add diethyl ether and is stirred to react 30min, crosses and filters out solid, filtrate is concentrated at 40 DEG C and eliminates
Solvent obtains powder；The mass ratio of solid and acetum after drying is 1:5, and the volume ratio of acetum and ether is 1:
0.3；
Prunella asiatica polysaccharide the preparation method comprises the following steps: (1) dry prunella asiatica and crush, add the acetum of 0.6wt%, be heated to flowing back
2hr is extracted, ethyl alcohol is added after being cooled to 25 DEG C, 60min is stood after stirring 30min, crosses and filter out solid, filtrate is at 35 ~ 42 DEG C
It is concentrated to get grease；The mass ratio of dry prunella asiatica and acetum is 1:5, and the volume ratio of acetum and ethyl alcohol is 1:
2.5；(2) grease is taken, P123 type PEO-PPO-PEO triblock copolymer, second alcohol and water is added, is stirred to react 30min, is filtered
Solid is taken, is dried at 45 DEG C；Grease, P123 type PEO-PPO-PEO triblock copolymer, second alcohol and water mass ratio be 1:
0.03:4:8。
The technology of the present invention effect major embodiment is in the following areas: the study found that by tangshenoside shown in formula I, aurantiin,
Vitamin A, prunella asiatica polysaccharide and lemon juice are combined in the ratio of the application, can play certain hair regrowth, and such as Formulas I
Shown in tangshenoside, aurantiin, vitamin A, each component of prunella asiatica polysaccharide it is more controllable, more compared to traditional dietotherapy or Chinese medicine
It is controllable；By being made into tablet, it is incorporated in the form of effervescent tablet and sorbierite, magnesium stearate, xanthan gum is added, obtained
Highly-water-soluble product, be conducive to the oral absorption of product, at the same by smeared outside sodium bicarbonate polyethylene glycol 2000 come
The disintegration during storage is reduced, the safety of product is improved；Radix Codonopsis shown in formula I is prepared by way of the application
On the one hand to solve cost problem, on the other hand originally glycosides, aurantiin, prunella asiatica polysaccharide can be relieved the inadequate property of commercial product
Yield and content can be improved in the method for application.
Specific embodiment
Embodiment 1a: tangshenoside shown in formula I is prepared by the following method:
(1) it dries Radix Codonopsis and crushes, add water, be heated to refluxing extraction 5hr, ethyl alcohol is added after being cooled to 25 DEG C, after stirring 30min
60min is stood, crosses and filters out solid, filtrate is concentrated into the 1/2 of original volume at 40 DEG C, obtains water extract；Dry Radix Codonopsis and
The mass ratio of water is 1:8, and the volume ratio of water and ethyl alcohol is 1:1.0；
(2) water intaking extract is added niacinamide and sodium bicarbonate, is stirred to react 30min, filters to take solid, dry at 45 DEG C；
The mass ratio of water extract, niacinamide and sodium bicarbonate is 1:0.06:0.05；
(3) solid after drying is put into the acetum of 0.6wt%, is stirred to react 30min, add ethyl alcohol and be stirred to react
30min is crossed and is filtered out solid, and filtrate is concentrated at 40 DEG C and eliminates solvent, obtains powder；The matter of solid and acetum after drying
Ratio is measured as 1:8, the volume ratio of acetum and ethyl alcohol is 1:0.6.
Embodiment 1b: tangshenoside shown in formula I is prepared by the following method:
(1) it dries Radix Codonopsis and crushes, add water, be heated to refluxing extraction 4hr, ethyl alcohol is added after being cooled to 20 DEG C, after stirring 20min
50min is stood, crosses and filters out solid, filtrate is concentrated into the 1/3 of original volume at 35 DEG C, obtains water extract；Dry Radix Codonopsis and
The mass ratio of water is 1:6, and the volume ratio of water and ethyl alcohol is 1:0.8；
(2) water intaking extract is added niacinamide and sodium bicarbonate, is stirred to react 20min, filters to take solid, dry at 40 DEG C；
The mass ratio of water extract, niacinamide and sodium bicarbonate is 1:0.05:0.04；
(3) solid after drying is put into the acetum of 0.5wt%, is stirred to react 40min, add ethyl alcohol and be stirred to react
40min is crossed and is filtered out solid, and filtrate is concentrated at 35 DEG C and eliminates solvent, obtains powder；The matter of solid and acetum after drying
Ratio is measured as 1:7, the volume ratio of acetum and ethyl alcohol is 1:0.5.
Embodiment 1c: tangshenoside shown in formula I is prepared by the following method:
(1) it dries Radix Codonopsis and crushes, add water, be heated to refluxing extraction 6hr, ethyl alcohol is added after being cooled to 30 DEG C, after stirring 40min
70min is stood, crosses and filters out solid, filtrate is concentrated into the 2/3 of original volume at 42 DEG C, obtains water extract；Dry Radix Codonopsis and
The mass ratio of water is 1:10, and the volume ratio of water and ethyl alcohol is 1:1.1；
(2) water intaking extract is added niacinamide and sodium bicarbonate, is stirred to react 40min, filters to take solid, dry at 50 DEG C；
The mass ratio of water extract, niacinamide and sodium bicarbonate is 1:0.07:0.06；
(3) solid after drying is put into the acetum of 0.8wt%, is stirred to react 20min, add ethyl alcohol and be stirred to react
20min is crossed and is filtered out solid, and filtrate is concentrated at 42 DEG C and eliminates solvent, obtains powder；The matter of solid and acetum after drying
Ratio is measured as 1:9, the volume ratio of acetum and ethyl alcohol is 1:0.8.
Embodiment 2a: aurantiin is prepared by the following method:
(1) it dries the rhizome of davallia and crushes, add ethyl alcohol, be heated to refluxing extraction 3hr, ether is added after being cooled to 25 DEG C, stir
60min is stood after 30min, is crossed and is filtered out solid, filtrate is concentrated into the 1/2 of original volume at 40 DEG C, obtains alcohol extracting thing；Dry
The mass ratio of the rhizome of davallia and ethyl alcohol is 1:5, and the volume ratio of ethyl alcohol and ether is 1:0.4；
(2) alcohol extracting thing is taken, carboxymethyl chitosan and sodium carbonate is added, is stirred to react 30min, filters to take solid, at 45 DEG C
Drying；The mass ratio of alcohol extracting thing, carboxymethyl chitosan and sodium carbonate is 1:0.05:0.02；
(3) solid after drying is put into the acetum of 0.6wt%, is stirred to react 30min, add diethyl ether and be stirred to react
30min is crossed and is filtered out solid, and filtrate is concentrated at 40 DEG C and eliminates solvent, obtains powder；The matter of solid and acetum after drying
Ratio is measured as 1:5, the volume ratio of acetum and ether is 1:0.3.
Embodiment 2b: aurantiin is prepared by the following method:
(1) it dries the rhizome of davallia and crushes, add ethyl alcohol, be heated to refluxing extraction 2hr, ether is added after being cooled to 20 DEG C, stir
50min is stood after 40min, is crossed and is filtered out solid, filtrate is concentrated into the 1/3 of original volume at 35 DEG C, obtains alcohol extracting thing；Dry
The mass ratio of the rhizome of davallia and ethyl alcohol is 1:4, and the volume ratio of ethyl alcohol and ether is 1:0.3；
(2) alcohol extracting thing is taken, carboxymethyl chitosan and sodium carbonate is added, is stirred to react 20min, filters to take solid, at 40 DEG C
Drying；The mass ratio of alcohol extracting thing, carboxymethyl chitosan and sodium carbonate is 1:0.04:0.01；
(3) solid after drying is put into the acetum of 0.5wt%, is stirred to react 20min, add diethyl ether and be stirred to react
20min is crossed and is filtered out solid, and filtrate is concentrated at 35 DEG C and eliminates solvent, obtains powder；The matter of solid and acetum after drying
Ratio is measured as 1:4, the volume ratio of acetum and ether is 1:0.2.
Embodiment 2c: aurantiin is prepared by the following method:
(1) it dries the rhizome of davallia and crushes, add ethyl alcohol, be heated to refluxing extraction 4hr, ether is added after being cooled to 30 DEG C, stir
70min is stood after 20min, is crossed and is filtered out solid, filtrate is concentrated into the 2/3 of original volume at 42 DEG C, obtains alcohol extracting thing；Dry
The mass ratio of the rhizome of davallia and ethyl alcohol is 1:6, and the volume ratio of ethyl alcohol and ether is 1:0.5；
(2) alcohol extracting thing is taken, carboxymethyl chitosan and sodium carbonate is added, is stirred to react 40min, filters to take solid, at 50 DEG C
Drying；The mass ratio of alcohol extracting thing, carboxymethyl chitosan and sodium carbonate is 1:0.06:0.03；
(3) solid after drying is put into the acetum of 0.8wt%, is stirred to react 40min, add diethyl ether and be stirred to react
40min is crossed and is filtered out solid, and filtrate is concentrated at 42 DEG C and eliminates solvent, obtains powder；The matter of solid and acetum after drying
Ratio is measured as 1:6, the volume ratio of acetum and ether is 1:0.4.
Embodiment 3a: prunella asiatica polysaccharide is prepared by the following method:
(1) it dries prunella asiatica and crushes, add the acetum of 0.6wt%, be heated to refluxing extraction 2hr, be added after being cooled to 25 DEG C
Ethyl alcohol stands 60min after stirring 30min, crosses and filter out solid, filtrate is concentrated to get grease at 35 ~ 42 DEG C；Dry mountain spinach
The mass ratio of dish and acetum is 1:5, and the volume ratio of acetum and ethyl alcohol is 1:2.5；
(2) grease is taken, P123 type PEO-PPO-PEO triblock copolymer, second alcohol and water is added, is stirred to react 30min, is filtered
Solid is taken, is dried at 45 DEG C；Grease, P123 type PEO-PPO-PEO triblock copolymer, second alcohol and water mass ratio be 1:
0.03:4:8。
Embodiment 3b: prunella asiatica polysaccharide is prepared by the following method:
(1) it dries prunella asiatica and crushes, add the acetum of 0.5wt%, be heated to refluxing extraction 1hr, be added after being cooled to 20 DEG C
Ethyl alcohol stands 50min after stirring 20min, crosses and filter out solid, filtrate is concentrated to get grease at 35 DEG C；Dry prunella asiatica
It is 1:4 with the mass ratio of acetum, the volume ratio of acetum and ethyl alcohol is 1:2.3；
(2) grease is taken, P123 type PEO-PPO-PEO triblock copolymer, second alcohol and water is added, is stirred to react 20min, is filtered
Solid is taken, is dried at 40 DEG C；Grease, P123 type PEO-PPO-PEO triblock copolymer, second alcohol and water mass ratio be 1:
0.02:3:6。
Embodiment 3c: prunella asiatica polysaccharide is prepared by the following method:
(1) it dries prunella asiatica and crushes, add the acetum of 0.8wt%, be heated to refluxing extraction 3hr, be added after being cooled to 30 DEG C
Ethyl alcohol stands 70min after stirring 40min, crosses and filter out solid, filtrate is concentrated to get grease at 42 DEG C；Dry prunella asiatica
It is 1:6 with the mass ratio of acetum, the volume ratio of acetum and ethyl alcohol is 1:2.7；
(2) grease is taken, P123 type PEO-PPO-PEO triblock copolymer, second alcohol and water is added, is stirred to react 40min, is filtered
Solid is taken, is dried at 50 DEG C；Grease, P123 type PEO-PPO-PEO triblock copolymer, second alcohol and water mass ratio be 1:
0.04:5:10。
Embodiment 4a: a kind of dietotherapy hair growth composition is tablet, is prepared by the following method:, will on fluidized bed
Polyethylene glycol 2000 aqueous solution is sprayed on outside nanoscale sodium bicarbonate and dries；By tangshenoside shown in formula I, aurantiin, dimension life
Plain A, prunella asiatica polysaccharide, lemon juice, sorbierite, magnesium stearate and citric acid are crushed and are sieved respectively, and xanthan gum is added and is coated with
The sodium bicarbonate of polyethylene glycol 2000, it is tabletted after mixing.
A kind of formula (by mass) of dietotherapy hair growth composition are as follows: 3.2 parts of tangshenosides shown in formula I (derive from
Embodiment 1a), 1.5 parts of aurantiins (deriving from embodiment 2a), 0.4 part of vitamin A, 5.0 parts of prunella asiatica polysaccharide are (from implementing
Example 3a), 1.0 portions of lemon juices (deriving from fresh squeezing), 1.8 parts of sorbierites, 5.0 parts of magnesium stearates, 0.6 part of xanthan gum, 0.6 portion of lemon
Acid, 0.6 part of sodium bicarbonate and 1.2 parts of polyethylene glycol 2000s.
Embodiment 4b: a kind of dietotherapy hair growth composition, is tablet, and the difference with embodiment 4a is, shown in formula I
Tangshenoside derive from embodiment 1b, aurantiin derive from embodiment 2b, prunella asiatica polysaccharide origin is in embodiment 3b.
Embodiment 4c: a kind of dietotherapy hair growth composition, is tablet, and the difference with embodiment 4a is, shown in formula I
Tangshenoside derive from embodiment 1c, aurantiin derive from embodiment 2c, prunella asiatica polysaccharide origin is in embodiment 3c.
Embodiment 4d: a kind of dietotherapy hair growth composition, is tablet, and the difference with embodiment 4a is, shown in formula I
Tangshenoside, aurantiin and prunella asiatica polysaccharide derive from commercial standard.
Embodiment 5: a kind of dietotherapy hair growth composition, is mixed powder, is formulated (by mass) are as follows: 3.2 parts of such as Formulas I institutes
The tangshenoside (from embodiment 1a) that shows, 1.5 parts of aurantiins (from embodiment 2a), 0.4 part of vitamin A, 5.0 parts of mountain spinach
Dish polysaccharide (deriving from embodiment 3a), 1.0 parts of lemon juices (deriving from fresh squeezing), 1.8 parts of sorbierites, 5.0 parts of magnesium stearates, 0.6
Part xanthan gum, 0.6 part of citric acid, 0.6 part of sodium bicarbonate and 1.2 parts of polyethylene glycol 2000s.
Embodiment 6: a kind of dietotherapy hair growth composition, is mixed powder, is formulated (by mass) are as follows: 3.2 parts of such as Formulas I institutes
The tangshenoside (from embodiment 1a) that shows, 1.5 parts of aurantiins (from embodiment 2a), 0.4 part of vitamin A, 5.0 parts of mountain spinach
Dish polysaccharide (deriving from embodiment 3a), 1.0 parts of lemon juices (deriving from fresh squeezing), 5.0 parts of black sesame powders fried and 5.0 parts steam
Polygonum multiflorum powder.
Embodiment 7: a kind of dietotherapy hair growth composition, is mixed powder, is formulated (by mass) are as follows: 3.2 parts of such as Formulas I institutes
The tangshenoside (from embodiment 1a) that shows, 1.5 parts of aurantiins (from embodiment 2a), 0.4 part of vitamin A, 5.0 parts of mountain spinach
Dish polysaccharide (deriving from embodiment 3a) and 1.0 parts of lemon juices (deriving from fresh squeezing).
Comparative examples 1: a kind of dietotherapy hair growth composition, is mixed powder, is formulated (by mass) are as follows: 20 Fen Gan parties
Ginseng, 20 parts of dry rhizomes of davallia, 0.4 part of vitamin A, 5.0 parts of dry prunella asiaticas and 1.0 parts of lemon juices (deriving from fresh squeezing).
Comparative examples 2: a kind of dietotherapy hair growth composition, is mixed powder, is formulated (by mass) are as follows: 0.4 part of dimension
Raw element A, 5.0 parts of prunella asiatica polysaccharide (deriving from embodiment 3a) and 1.0 parts of lemon juices (deriving from fresh squeezing).
Comparative examples 3: a kind of dietotherapy hair growth composition, is mixed powder, is formulated (by mass) are as follows: 1.5 parts of shaddocks
Skin glycosides (deriving from embodiment 2a), 0.4 part of vitamin A and 1.0 parts of lemon juices (deriving from fresh squeezing).
Comparative examples 4: a kind of dietotherapy hair growth composition, is mixed powder, is formulated (by mass) are as follows: 3.2 parts such as
Tangshenoside shown in Formulas I (deriving from embodiment 1a), 0.4 part of vitamin A and 1.0 parts of lemon juices (deriving from fresh squeezing).
Comparative examples 5: a kind of dietotherapy hair growth composition, is mixed powder, is formulated (by mass) are as follows: 3.2 parts such as
Tangshenoside shown in Formulas I (deriving from embodiment 1a), 5.0 parts of prunella asiatica polysaccharide (deriving from embodiment 3a) and 1.0 portions of lemon juices
(deriving from fresh squeezing).
Embodiment 1a-1c characterization
(1) qualitative analysis
Embodiment 1a-1c is identified by nuclear-magnetism, is tangshenoside shown in formula I.
(2) content measuring
The standard items of tangshenoside shown in formula I are taken, configuration standard curve point tests absorbance using ultraviolet absorbable method, with
Absorbance is ordinate, tangshenoside's concentration shown in formula I is that abscissa makees standard curve, makees standard curve after linear analogue and returns
Return equation；5mg sample is taken, is settled to 25ml with water, obtains sample aqueous solution, tests absorbance, it is molten according to regression equation calculation
The concentration C (unit mg/ml) of liquid calculates content X=C × 25 × 100%/5 of sample.It parallel test 5 times, is averaged.
Test result: tangshenoside's content shown in formula I is respectively in embodiment 1a, embodiment 1b and embodiment 1c
98.6%, 91.0% and 90.2%.
(3) yield is tested
The dry Radix Codonopsis and 10ml water to constant weight of 500mg is taken, back flow reaction 10hr is heated to, shifted with water and is settled to 25ml appearance
In measuring bottle, by tangshenoside's content shown in formula I in the method measurement Radix Codonopsis of content measuring, parallel test 5 times, it is averaged.
Yield=(tangshenoside's content in 100% × sample × sample dry weight being collected into)/(dry into the Radix Codonopsis of constant weight
The dry weight of the Radix Codonopsis for the content of tangshenoside × feed intake).
Test result: in embodiment 1a, embodiment 1b and embodiment 1c yield shown in formula I be respectively 92.3%,
80.1% and 81.4%.
Embodiment 2a-2c characterization
(1) qualitative analysis
Embodiment 2a-2c is identified by nuclear-magnetism, is aurantiin.
(2) content measuring
The standard items of aurantiin are taken, it is vertical sit with absorbance that configuration standard curve point, which tests absorbance using ultraviolet absorbable method,
Mark, aurantiin concentration are that abscissa makees standard curve, make standard curve regression equation after linear analogue；8mg sample is taken, it is fixed with water
Hold to 25ml, obtain sample aqueous solution, test absorbance, according to regression equation calculation solution concentration C (unit mg/ml), meter
Calculate content X=C × 25 × 100%/5 of sample.It parallel test 5 times, is averaged.
Test result: naringin content is respectively 99.1%, 90.1% and in embodiment 2a, embodiment 2b and embodiment 2c
89.3%。
(3) yield is tested
The dry rhizome of davallia and 20ml ethyl alcohol to constant weight of 400mg is taken, back flow reaction 10hr is heated to, 25ml is transferred to ethyl alcohol and holds
In measuring bottle, nitrogen blows down solvent to the greatest extent, with 50wt% ethanol water constant volume, measures in the rhizome of davallia by the method for content measuring such as Formulas I institute
The naringin content shown parallel test 5 times, is averaged.
Yield=(naringin content in 100% × sample × sample dry weight being collected into)/(the dry rhizome of davallia to constant weight
The dry weight of the rhizome of davallia for the content of middle aurantiin × feed intake).
Test result: the yield of aurantiin is respectively 89.6%, 77.4% and in embodiment 2a, embodiment 2b and embodiment 2c
75.7%。
Embodiment 3a-3c characterization
Referring to the side of the master thesis " extraction, purifying and the activity research of prunella asiatica polysaccharide " of Hebei United University Shen Pan Pan
Method tests content and yield.
Test result: in embodiment 3a, embodiment 3b and embodiment 3c the content of prunella asiatica polysaccharide be respectively 98.1%,
90.0% and 89.3%.
The yield of prunella asiatica polysaccharide is respectively 88.7%, 79.1% and in embodiment 3a, embodiment 3b and embodiment 3c
80.7%。
The solubility test of hair growth composition
Take 5mg sample, the solubility in 25 DEG C of test and 37 DEG C of water.
In 25 DEG C of water, embodiment 4a, embodiment 4b, embodiment 4c and embodiment 5 solubility be 2 ~ 4mg/ml, it is real
The solubility for applying example 6 and embodiment 7 is respectively less than 0.05mg/ml.
In 37 DEG C of water, embodiment 4a, embodiment 4b, embodiment 4c and embodiment 5 solubility be 16 ~ 20mg/ml,
The solubility of embodiment 6 and embodiment 7 is respectively less than 0.05mg/ml.
Mouse hair tonic test
Selecting 130 weight is 23-27 grams of healthy male white mouse, and the hair at the back of all small white mouses is turned down with hairclipper, then uses
Small white mouse is randomly divided into 13 groups: one groups as blank control group by depilatory agent defeathering, remaining 12 groups feed respectively embodiment 4a-4d,
Embodiment 5-7 and comparative examples 1-5.Wherein the use form of embodiment 4a-4d be configured to 25 DEG C of 2mg/ml it is water-soluble
The use form of liquid, embodiment 5-7 and comparative examples 1-5 are directly to feed solid, and blank control does not carry out feeding hair tonic
Product.It feeds 1 time, each 0.1g daily, test grows the length of hair after 7 days and 30 days and finds out the average value of each group.
Test result is as shown in table 1.Table 1 is shown: being compared with blank control and comparative examples 1-5, is used embodiment
The hair tonic of the small white mouse of 4a-4d and embodiment 5-7 is longer faster, wherein embodiment 4 eh, the hair-growing effects of -4d it is the most obvious.
1 mouse hair tonic of table test
| Group | Staple length average value (mm) after 7 days | Staple length average value (mm) after 30 days |
| Blank control | 4.0 | 17.5 |
| Embodiment 4a | 45.2 | 244.5 |
| Embodiment 4b | 40.2 | 221.1 |
| Embodiment 4c | 40.4 | 222.7 |
| Embodiment 4d | 45.0 | 243.7 |
| Embodiment 5 | 32.3 | 168.7 |
| Embodiment 6 | 29.2 | 140.6 |
| Embodiment 7 | 24.5 | 125.4 |
| Comparative examples 1 | 8.2 | 38.6 |
| Comparative examples 2 | 10.1 | 56.7 |
| Comparative examples 3 | 9.5 | 51.2 |
| Comparative examples 4 | 7.3 | 36.1 |
| Comparative examples 5 | 8.5 | 40.9 |
Certainly, above is representative instance of the invention, and in addition to this, the present invention can also have other a variety of specific embodiment parties
Formula, all technical solutions formed using equivalent substitution or equivalent transformation, is all fallen within the scope of protection of present invention.
Claims (7)
1. a kind of dietotherapy hair growth composition, characterized in that by mass, including following components: 2.5 ~ 4.0 parts shown in formula I
Tangshenoside, 1.2 ~ 1.8 parts of aurantiins, 0.3 ~ 0.5 part of vitamin A, 4.5 ~ 5.2 parts of prunella asiatica polysaccharide and 0.8 ~ 1.1 portion of lemon juice；
(I)。
2. a kind of dietotherapy hair growth composition according to claim 1, characterized in that further include following components by mass:
1.5 ~ 2.0 parts of sorbierites, 4.5 ~ 6.0 parts of magnesium stearates, 0.5 ~ 0.8 part of xanthan gum, 0.5 ~ 0.8 part of citric acid and 0.5 ~ 0.8 part
Sodium bicarbonate；One layer of polyethylene glycol 2000, the matter of the sodium bicarbonate and polyethylene glycol 2000 are coated with outside the sodium bicarbonate
Amount is than being 1:0.15 ~ 0.22.
3. a kind of dietotherapy hair growth composition according to claim 2, characterized in that a kind of dietotherapy hair growth composition is
Tablet is prepared by the following method: on fluidized bed, polyethylene glycol 2000 aqueous solution being sprayed on outside nanoscale sodium bicarbonate
Drying；By tangshenoside shown in formula I, aurantiin, vitamin A, prunella asiatica polysaccharide, lemon juice, sorbierite, magnesium stearate and lemon
Lemon acid is crushed and is sieved respectively, and xanthan gum is added and is coated with the sodium bicarbonate of polyethylene glycol 2000, tabletted after mixing.
4. a kind of dietotherapy hair growth composition according to claim 3, characterized in that by mass, including following components:
3.2 parts of tangshenosides shown in formula I, 1.5 parts of aurantiins, 0.4 part of vitamin A, 5.0 parts of prunella asiatica polysaccharide, 1.0 portions of lemon juices,
1.8 parts of sorbierites, 5.0 parts of magnesium stearates, 0.6 part of xanthan gum, 0.6 part of citric acid and 0.6 part of sodium bicarbonate；The sodium bicarbonate
It is coated with one layer of polyethylene glycol 2000 outside, the mass ratio of the sodium bicarbonate and polyethylene glycol 2000 is 1:0.20.
5. a kind of dietotherapy hair growth composition according to claim 1, characterized in that by mass, including following components:
3.2 parts of tangshenosides shown in formula I, 1.5 parts of aurantiins, 0.4 part of vitamin A, 5.0 parts of prunella asiatica polysaccharide, 1.0 portions of lemon juices,
5.0 parts of black sesame powders fried and 5.0 parts steam polygonum multiflorum powder.
6. a kind of dietotherapy hair growth composition according to claim 1-5, characterized in that
Tangshenoside the preparation method comprises the following steps: (1) dry Radix Codonopsis and crush shown in formula I, adds water, is heated to 4 ~ 6hr of refluxing extraction,
Ethyl alcohol is added after being cooled to 20 ~ 30 DEG C, stands 50 ~ 70min after stirring 20 ~ 40min, crosses and filter out solid, filtrate is at 35 ~ 42 DEG C
It is concentrated into the 1/3 ~ 2/3 of original volume, obtains water extract；The mass ratio of dry Radix Codonopsis and water is 1:6 ~ 10, water and ethyl alcohol
Volume ratio is 1:0.8 ~ 1.1；(2) water intaking extract is added niacinamide and sodium bicarbonate, is stirred to react 20 ~ 40min, filters to take
Solid is dried at 40 ~ 50 DEG C；The mass ratio of water extract, niacinamide and sodium bicarbonate be 1:0.05 ~ 0.07:0.04 ~
0.06；(3) solid after drying is put into the acetum of 0.5 ~ 0.8wt%, is stirred to react 20 ~ 40min, add ethyl alcohol and stirred
20 ~ 40min of reaction is mixed, crosses and filters out solid, filtrate is concentrated at 35 ~ 42 DEG C and eliminates solvent, obtains powder；Solid after drying and
The mass ratio of acetum is 1:7 ~ 9, and the volume ratio of acetum and ethyl alcohol is 1:0.5 ~ 0.8；
Aurantiin the preparation method comprises the following steps: (1) dry rhizome of davallia and crush, add ethyl alcohol, be heated to 2 ~ 4hr of refluxing extraction, be cooled to
Ether is added after 20 ~ 30 DEG C, stands 50 ~ 70min after stirring 20 ~ 40min, crosses and filter out solid, filtrate is concentrated at 35 ~ 42 DEG C
The 1/3 ~ 2/3 of original volume, obtains alcohol extracting thing；The mass ratio of the dry rhizome of davallia and ethyl alcohol is 1:4 ~ 6, the body of ethyl alcohol and ether
Product is than being 1:0.3 ~ 0.5；(2) alcohol extracting thing is taken, carboxymethyl chitosan and sodium carbonate is added, is stirred to react 20 ~ 40min, is filtered
Solid is taken, is dried at 40 ~ 50 DEG C；The mass ratio of alcohol extracting thing, carboxymethyl chitosan and sodium carbonate is 1:0.04 ~ 0.06:
0.01~0.03；(3) solid after drying is put into the acetum of 0.5 ~ 0.8wt%, is stirred to react 20 ~ 40min, added diethyl ether
And it is stirred to react 20 ~ 40min, it crosses and filters out solid, filtrate is concentrated at 35 ~ 42 DEG C and eliminates solvent, obtains powder；Consolidating after drying
The mass ratio of body and acetum is 1:4 ~ 6, and the volume ratio of acetum and ether is 1:0.2 ~ 0.4；
Prunella asiatica polysaccharide the preparation method comprises the following steps: (1) dry prunella asiatica and crush, add the acetum of 0.5 ~ 0.8wt%, be heated to
Ethyl alcohol is added in 1 ~ 3hr of refluxing extraction after being cooled to 20 ~ 30 DEG C, stand 50 ~ 70min after stirring 20 ~ 40min, cross and filter out solid,
Filtrate is concentrated to get grease at 35 ~ 42 DEG C；The mass ratio of dry prunella asiatica and acetum is 1:4 ~ 6, acetum
Volume ratio with ethyl alcohol is 1:2.3 ~ 2.7；(2) grease is taken, P123 type PEO-PPO-PEO triblock copolymer, ethyl alcohol is added
And water, it is stirred to react 20 ~ 40min, filters to take solid, is dried at 40 ~ 50 DEG C；Grease, P123 type PEO-PPO-PEO tri- are embedding
Section copolymer, second alcohol and water mass ratio be 1:0.02 ~ 0.04:3 ~ 5:6 ~ 10.
7. a kind of dietotherapy hair growth composition according to claim 6, characterized in that
Tangshenoside the preparation method comprises the following steps: (1) dry Radix Codonopsis and crush shown in formula I, adds water, is heated to refluxing extraction 5hr, drop
Temperature stands 60min after stirring 30min, crosses and filter out solid, filtrate is concentrated into original volume at 40 DEG C to ethyl alcohol is added after 25 DEG C
1/2, obtain water extract；The mass ratio of dry Radix Codonopsis and water is 1:8, and the volume ratio of water and ethyl alcohol is 1:1.0；(2) it fetches water
Extract is added niacinamide and sodium bicarbonate, is stirred to react 30min, filters to take solid, dry at 45 DEG C；Water extract, cigarette
The mass ratio of amide and sodium bicarbonate is 1:0.06:0.05；(3) solid after drying is put into the acetum of 0.6wt%,
It is stirred to react 30min, add ethyl alcohol and is stirred to react 30min, crosses and filters out solid, filtrate is concentrated at 40 DEG C and eliminates solvent, obtains
Powder；The mass ratio of solid and acetum after drying is 1:8, and the volume ratio of acetum and ethyl alcohol is 1:0.6；
Aurantiin the preparation method comprises the following steps: (1) dry rhizome of davallia and crush, add ethyl alcohol, be heated to refluxing extraction 3hr, be cooled to 25
Ether is added after DEG C, stands 60min after stirring 30min, crosses and filter out solid, filtrate is concentrated into the 1/2 of original volume at 40 DEG C, obtains
To alcohol extracting thing；The mass ratio of the dry rhizome of davallia and ethyl alcohol is 1:5, and the volume ratio of ethyl alcohol and ether is 1:0.4；(2) alcohol is taken
Extract is added carboxymethyl chitosan and sodium carbonate, is stirred to react 30min, filters to take solid, dry at 45 DEG C；Alcohol extracting
The mass ratio of object, carboxymethyl chitosan and sodium carbonate is 1:0.05:0.02；(3) solid after drying is put into the vinegar of 0.6wt%
In acid solution, it is stirred to react 30min, add diethyl ether and is stirred to react 30min, crosses and filters out solid, filtrate is concentrated at 40 DEG C and eliminates
Solvent obtains powder；The mass ratio of solid and acetum after drying is 1:5, and the volume ratio of acetum and ether is 1:
0.3；
Prunella asiatica polysaccharide the preparation method comprises the following steps: (1) dry prunella asiatica and crush, add the acetum of 0.6wt%, be heated to flowing back
2hr is extracted, ethyl alcohol is added after being cooled to 25 DEG C, 60min is stood after stirring 30min, crosses and filter out solid, filtrate is at 35 ~ 42 DEG C
It is concentrated to get grease；The mass ratio of dry prunella asiatica and acetum is 1:5, and the volume ratio of acetum and ethyl alcohol is 1:
2.5；(2) grease is taken, P123 type PEO-PPO-PEO triblock copolymer, second alcohol and water is added, is stirred to react 30min, is filtered
Solid is taken, is dried at 45 DEG C；Grease, P123 type PEO-PPO-PEO triblock copolymer, second alcohol and water mass ratio be 1:
0.03:4:8。
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