CN109481363A - A kind of mosquito repellent, antipruritic, anti-inflammatory floral water and preparation method thereof - Google Patents
A kind of mosquito repellent, antipruritic, anti-inflammatory floral water and preparation method thereof Download PDFInfo
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Abstract
The present invention provides a kind of mosquito repellents, antipruritic, anti-inflammatory floral water and preparation method thereof, which is prepared by the raw material of following parts by weight: 7-14 parts of the root of Dahurain angelica, 6-12 parts of honeysuckle, 4-8 parts of peppermint, 5-10 parts of perilla leaf, 6-10 parts of cloves, 3-7 parts of frutus cnidii, 8-16 parts of mulberry leaf, 4-9 parts of the fruit of summer cypress, 3-6 parts of Radix Glycyrrhizae, 6-15 parts of purslane, 10-20 parts of dandelion, 9-14 parts of Radix Paeoniae Alba, 10-18 parts of butanediol, 2-5 parts of trehalose, 30-50 parts of deionized water.Raw material of the present invention using Chinese medical extract as floral water substitutes micro- malicious chemical substance, has no toxic and side effect to human body, and the mosquito repellent time of floral water is up to 9h or more, has good repelling effect.Floral water has significant effect for inflammation caused by bite by mosquitos, symptom of itching simultaneously, and antipruritic effect is rapid-action, illustrates each ingredient synergistic effect in floral water of the present invention, has played better antipruritic, anti-inflammatory effects.
Description
Technical field
The invention belongs to household chemicals technical fields, and in particular to a kind of mosquito repellent, antipruritic, anti-inflammatory floral water and its preparation
Method.
Background technique
Floral water is the distinctive household chemicals of China, uses liquid distilled from honeysuckle flowers or lotus leaves oil as main body fragrance earliest, with made of ethyl alcohol one
Kind perfume class product, main function are to cover smell, have degerming decontamination concurrently.Its prescription be 3% or so essence, 70% or so
Alcohol and 25% distilled water.Since this proportion is easily penetrated into inside bacterium, floral water, which also can be used as dulcet disinfectant, to be made
With.Floral water is continuously improved on prescription and technique now, on the basis of retaining original main side, is added some with heat-clearing solution
The traditional Chinese medicine ingredients of poison, swelling and pain relieving function also have removing miliaria and relieving itching, treatment skin to make floral water other than original effect
Disease refreshes the mind and other effects.Menthol ingredient is added in such as floral water, is allowed to more refrigerant；Culicifuge is added, makes it have
Repelling effect.In addition, being often aided with the ingredients such as a small amount of chelating agent, antioxidant and pigment in floral water, improves it and see praising property, safety
Property, stability and its effect.Floral water, which has become, at present solves the hot dry equal skin diseases essential product of itching of hot summer miliaria.
However, the functional component of most liquid distilled from honeysuckle flowers or lotus leaves aquatic products is micro- malicious chemical substance currently on the market, Long Term Contact is easy
Irritation and anaphylaxis are generated to sensitive skin, meanwhile, more floral water contains denseer penetrating odor, the function without anti-inflammatory
Effect.Therefore, it is necessary to further be developed to liquid distilled from honeysuckle flowers or lotus leaves aquatic products, realize floral water safety non-toxic, it is nonirritant, without allergy
The performances such as property, the feature of environmental protection, to meet the important development direction and trend of liquid distilled from honeysuckle flowers or lotus leaves market for water.
Summary of the invention
Above of the existing technology in order to solve the problems, such as, the purpose of the present invention is to provide a kind of mosquito repellents, antipruritic, anti-inflammatory
Floral water and preparation method thereof.
To achieve the goals above, the present invention the following technical schemes are provided:
A kind of mosquito repellent, antipruritic, anti-inflammatory floral water, are prepared: 7-14 parts of the root of Dahurain angelica, honeysuckle 6-12 by the raw material of following parts by weight
Part, 4-8 parts of peppermint, 5-10 parts of perilla leaf, 6-10 parts of cloves, 3-7 parts of frutus cnidii, 8-16 parts of mulberry leaf, 4-9 parts of the fruit of summer cypress, Radix Glycyrrhizae 3-6
Part, 6-15 parts of purslane, 10-20 parts of dandelion, 9-14 parts of Radix Paeoniae Alba, 10-18 parts of butanediol, 2-5 parts of trehalose, deionized water
30-50 parts.
Preferably, a kind of mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water, by the raw material preparation of following parts by weight
At: 8-12 parts of the root of Dahurain angelica, 7-10 parts of honeysuckle, 4-6 parts of peppermint, 6-9 parts of perilla leaf, 7-10 parts of cloves, 4-6 parts of frutus cnidii, mulberry leaf 10-
15 parts, 5-8 parts of the fruit of summer cypress, 4-6 parts of Radix Glycyrrhizae, 8-14 parts of purslane, 12-18 parts of dandelion, 10-13 parts of Radix Paeoniae Alba, butanediol 12-16
Part, 2-4 parts of trehalose, 35-45 parts of deionized water.
Preferably, a kind of mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water, by the raw material preparation of following parts by weight
At: 10 parts of the root of Dahurain angelica, 9 parts of honeysuckle, 5 parts of peppermint, 7.5 parts of perilla leaf, 8.5 parts of cloves, 5 parts of frutus cnidii, 12.5 parts of mulberry leaf, the fruit of summer cypress
7 parts, 5 parts of Radix Glycyrrhizae, 11 parts of purslane, 15 parts of dandelion, 12 parts of Radix Paeoniae Alba, 14 parts of butanediol, 3 parts of trehalose, 40 parts of deionized water.
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, comprising the following steps:
(1) weigh by weight the root of Dahurain angelica, honeysuckle, peppermint, perilla leaf, cloves, frutus cnidii, mulberry leaf, the fruit of summer cypress, Radix Glycyrrhizae, purslane,
Dandelion, Radix Paeoniae Alba are put into pulverizer and crush acquisition coarse powder, be put into reaction vessel after coarse powder is taken out, then add thereto
The volume fraction for entering 5-10 times of parts by weight of coarse powder total weight is the ethyl alcohol of 70-80%, after impregnating 8-12h, at a temperature of 50-60 DEG C
Ultrasonic extraction 40-60min, then filters reaction system, collects filtrate, obtains filter residue；Again according to identical condition by filter residue
Secondary carry out ultrasonic extraction, filtering and collecting filter liquid discard filter residue, and the filtrate extracted twice is merged, and obtain crude extract；
(2) crude extract is subjected to vacuum distillation by Rotary Evaporators and gets rid of ethyl alcohol, obtain concentrate；
(3) concentrate is centrifuged under the revolving speed of 2000-3000r/min 5-10min, collects supernatant；By supernatant ultrafiltration
Film carries out ultrafiltration, and it is 1.10-1.20g/mL to get Chinese medicine extract that ultrafiltrate, which is concentrated under reduced pressure into relative density at 60 DEG C,；
(4) Chinese medicine extract is added in butanediol solution, trehalose is added under stirring conditions, in 300-500r/min's
20-40min is stirred under revolving speed, and mixture is made；
(5) it adds mixture in deionized water, is uniformly mixed, stand 1-4 weeks under the conditions of 4 DEG C, then pass through filter
Film filtering, obtains filtrate；
(6) filtrate obtains mosquito repellent, antipruritic, anti-inflammatory floral water through encapsulating, packaging.
Further, mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method are super in the step (1)
Acoustic frequency is 30-50kHz.
Further, mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, ultrafiltration in the step (3)
The molecular cut off of film is not less than 10000.
The utility model has the advantages that the present invention is in the present invention provides a kind of mosquito repellent, antipruritic, anti-inflammatory floral water and preparation method thereof
Raw material of the medicament extract as floral water substitutes micro- malicious chemical substance, has no toxic and side effect to human body, avoid Long Term Contact to quick
Feel irritation and anaphylaxis that skin generates, meets the important development direction and trend of liquid distilled from honeysuckle flowers or lotus leaves market for water.Pass through test result
It obtains, the mosquito repellent time of floral water produced by the present invention is up to 9h or more, has good repelling effect.Simultaneously floral water for
Inflammation caused by bite by mosquitos, symptom of itching have significant effect, and antipruritic effect is rapid-action, illustrates each in floral water of the present invention
Ingredient synergistic effect, has played better antipruritic, anti-inflammatory effects.
Specific embodiment
The invention will now be further described with reference to specific embodiments, but examples are merely exemplary, not to this hair
Bright range constitutes any restrictions.It will be understood by those skilled in the art that without departing from the spirit and scope of the invention
Can with the details and forms of the technical scheme of the invention are modified or replaced, but these modification and replacement each fall within it is of the invention
In protection scope.
Embodiment 1
A kind of mosquito repellent, antipruritic, anti-inflammatory floral water, are prepared by the raw material of following parts by weight: 10 parts of the root of Dahurain angelica, 9 parts of honeysuckle, thin
5 parts of lotus, 7.5 parts of perilla leaf, 8.5 parts of cloves, 5 parts of frutus cnidii, 12.5 parts of mulberry leaf, 7 parts of the fruit of summer cypress, 5 parts of Radix Glycyrrhizae, 11 parts of purslane,
15 parts of dandelion, 12 parts of Radix Paeoniae Alba, 14 parts of butanediol, 3 parts of trehalose, 40 parts of deionized water.
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, comprising the following steps:
(1) weigh by weight the root of Dahurain angelica, honeysuckle, peppermint, perilla leaf, cloves, frutus cnidii, mulberry leaf, the fruit of summer cypress, Radix Glycyrrhizae, purslane,
Dandelion, Radix Paeoniae Alba are put into pulverizer and crush acquisition coarse powder, be put into reaction vessel after coarse powder is taken out, then add thereto
Enter the ethyl alcohol that the volume fraction of 7 times of parts by weight of coarse powder total weight is 75%, after impregnating 10h, ultrasonic extraction at a temperature of 55 DEG C
50min then filters reaction system, collects filtrate, obtains filter residue；Filter residue is carried out ultrasound according to identical condition again to mention
It takes, filtering and collecting filter liquid discards filter residue, and the filtrate extracted twice is merged, and obtains crude extract；
(2) crude extract is subjected to vacuum distillation by Rotary Evaporators and gets rid of ethyl alcohol, obtain concentrate；
(3) concentrate is centrifuged under the revolving speed of 2500r/min 7min, collects supernatant；Supernatant is surpassed with ultrafiltration membrane
Filter, it is 1.10-1.20g/mL to get Chinese medicine extract that ultrafiltrate, which is concentrated under reduced pressure into relative density at 60 DEG C,；
(4) Chinese medicine extract is added in butanediol solution, trehalose is added under stirring conditions, in the revolving speed of 400r/min
Mixture is made in lower stirring 20-40min；
(5) it adds mixture in deionized water, is uniformly mixed, stand 3 weeks under the conditions of 4 DEG C, then pass through filter membrane
Filtering, obtains filtrate；
(6) filtrate obtains mosquito repellent, antipruritic, anti-inflammatory floral water through encapsulating, packaging.
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, the supersonic frequency in the step (1) are
40kHz。
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, the retention of ultrafiltration membrane in the step (3)
Molecular weight is 20000.
Embodiment 2
A kind of mosquito repellent, antipruritic, anti-inflammatory floral water, are prepared by the raw material of following parts by weight: 7 parts of the root of Dahurain angelica, 6 parts of honeysuckle, thin
4 parts of lotus, 5 parts of perilla leaf, 6 parts of cloves, 3 parts of frutus cnidii, 8 parts of mulberry leaf, 4 parts of the fruit of summer cypress, 3 parts of Radix Glycyrrhizae, 6 parts of purslane, dandelion 10
Part, 9 parts of Radix Paeoniae Alba, 10 parts of butanediol, 2 parts of trehalose, 30 parts of deionized water.
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, comprising the following steps:
(1) weigh by weight the root of Dahurain angelica, honeysuckle, peppermint, perilla leaf, cloves, frutus cnidii, mulberry leaf, the fruit of summer cypress, Radix Glycyrrhizae, purslane,
Dandelion, Radix Paeoniae Alba are put into pulverizer and crush acquisition coarse powder, be put into reaction vessel after coarse powder is taken out, then add thereto
Enter the ethyl alcohol that the volume fraction of 5 times of parts by weight of coarse powder total weight is 70%, after impregnating 8h, ultrasonic extraction at 50 °C
40min then filters reaction system, collects filtrate, obtains filter residue；Filter residue is carried out ultrasound according to identical condition again to mention
It takes, filtering and collecting filter liquid discards filter residue, and the filtrate extracted twice is merged, and obtains crude extract；
(2) crude extract is subjected to vacuum distillation by Rotary Evaporators and gets rid of ethyl alcohol, obtain concentrate；
(3) concentrate is centrifuged under the revolving speed of 2000r/min 5min, collects supernatant；Supernatant is surpassed with ultrafiltration membrane
Filter, it is 1.10-1.20g/mL to get Chinese medicine extract that ultrafiltrate, which is concentrated under reduced pressure into relative density at 60 DEG C,；
(4) Chinese medicine extract is added in butanediol solution, trehalose is added under stirring conditions, in the revolving speed of 300r/min
Mixture is made in lower stirring 20min；
(5) it adds mixture in deionized water, is uniformly mixed, stand 1 week under the conditions of 4 DEG C, then pass through filter membrane
Filtering, obtains filtrate；
(6) filtrate obtains mosquito repellent, antipruritic, anti-inflammatory floral water through encapsulating, packaging.
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, the supersonic frequency in the step (1) are
30kHz。
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, the retention of ultrafiltration membrane in the step (3)
Molecular weight is 20000.
Embodiment 3
A kind of mosquito repellent, antipruritic, anti-inflammatory floral water, are prepared by the raw material of following parts by weight: 9 parts of the root of Dahurain angelica, 8 parts of honeysuckle, thin
45 parts of lotus, 6 parts of perilla leaf, 7 parts of cloves, 4 parts of frutus cnidii, 10 parts of mulberry leaf, 6 parts of the fruit of summer cypress, 4 parts of Radix Glycyrrhizae, 8 parts of purslane, dandelion
12 parts, 11 parts of Radix Paeoniae Alba, 12 parts of butanediol, 3 parts of trehalose, 35 parts of deionized water.
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, comprising the following steps:
(1) weigh by weight the root of Dahurain angelica, honeysuckle, peppermint, perilla leaf, cloves, frutus cnidii, mulberry leaf, the fruit of summer cypress, Radix Glycyrrhizae, purslane,
Dandelion, Radix Paeoniae Alba are put into pulverizer and crush acquisition coarse powder, be put into reaction vessel after coarse powder is taken out, then add thereto
Enter the ethyl alcohol that the volume fraction of 6 times of parts by weight of coarse powder total weight is 72%, after impregnating 9h, ultrasonic extraction at a temperature of 53 DEG C
45min then filters reaction system, collects filtrate, obtains filter residue；Filter residue is carried out ultrasound according to identical condition again to mention
It takes, filtering and collecting filter liquid discards filter residue, and the filtrate extracted twice is merged, and obtains crude extract；
(2) crude extract is subjected to vacuum distillation by Rotary Evaporators and gets rid of ethyl alcohol, obtain concentrate；
(3) concentrate is centrifuged under the revolving speed of 2200r/min 6min, collects supernatant；Supernatant is surpassed with ultrafiltration membrane
Filter, it is 1.10-1.20g/mL to get Chinese medicine extract that ultrafiltrate, which is concentrated under reduced pressure into relative density at 60 DEG C,；
(4) Chinese medicine extract is added in butanediol solution, trehalose is added under stirring conditions, in the revolving speed of 350r/min
Mixture is made in lower stirring 25min；
(5) it adds mixture in deionized water, is uniformly mixed, stand 2 weeks under the conditions of 4 DEG C, then pass through filter membrane
Filtering, obtains filtrate；
(6) filtrate obtains mosquito repellent, antipruritic, anti-inflammatory floral water through encapsulating, packaging.
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, the supersonic frequency in the step (1) are
35kHz。
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, the retention of ultrafiltration membrane in the step (3)
Molecular weight is 20000.
Embodiment 4
A kind of mosquito repellent, antipruritic, anti-inflammatory floral water, are prepared by the raw material of following parts by weight: 14 parts of the root of Dahurain angelica, 12 parts of honeysuckle,
8 parts of peppermint, 10 parts of perilla leaf, 10 parts of cloves, 7 parts of frutus cnidii, 16 parts of mulberry leaf, 9 parts of the fruit of summer cypress, 6 parts of Radix Glycyrrhizae, 15 parts of purslane, Pu
20 parts of public English, 14 parts of Radix Paeoniae Alba, 18 parts of butanediol, 5 parts of trehalose, 50 parts of deionized water.
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, comprising the following steps:
(1) weigh by weight the root of Dahurain angelica, honeysuckle, peppermint, perilla leaf, cloves, frutus cnidii, mulberry leaf, the fruit of summer cypress, Radix Glycyrrhizae, purslane,
Dandelion, Radix Paeoniae Alba are put into pulverizer and crush acquisition coarse powder, be put into reaction vessel after coarse powder is taken out, then add thereto
Enter the ethyl alcohol that the volume fraction of 10 times of parts by weight of coarse powder total weight is 80%, after impregnating 12h, ultrasonic extraction at a temperature of 60 DEG C
60min then filters reaction system, collects filtrate, obtains filter residue；Filter residue is carried out ultrasound according to identical condition again to mention
It takes, filtering and collecting filter liquid discards filter residue, and the filtrate extracted twice is merged, and obtains crude extract；
(2) crude extract is subjected to vacuum distillation by Rotary Evaporators and gets rid of ethyl alcohol, obtain concentrate；
(3) concentrate is centrifuged under the revolving speed of 3000r/min 10min, collects supernatant；Supernatant is surpassed with ultrafiltration membrane
Filter, it is 1.10-1.20g/mL to get Chinese medicine extract that ultrafiltrate, which is concentrated under reduced pressure into relative density at 60 DEG C,；
(4) Chinese medicine extract is added in butanediol solution, trehalose is added under stirring conditions, in the revolving speed of 500r/min
Mixture is made in lower stirring 40min；
(5) it adds mixture in deionized water, is uniformly mixed, stand 4 weeks under the conditions of 4 DEG C, then pass through filter membrane
Filtering, obtains filtrate；
(6) filtrate obtains mosquito repellent, antipruritic, anti-inflammatory floral water through encapsulating, packaging.
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, the supersonic frequency in the step (1) are
50kHz。
Mosquito repellent of the present invention, antipruritic, anti-inflammatory floral water preparation method, the retention of ultrafiltration membrane in the step (3)
Molecular weight is 30000.
Comparative example 1
A kind of mosquito repellent, antipruritic, anti-inflammatory floral water, are prepared by the raw material of following parts by weight: 14 parts of the root of Dahurain angelica, 12 parts of honeysuckle,
8 parts of peppermint, 10 parts of perilla leaf, 7 parts of frutus cnidii, 16 parts of mulberry leaf, 9 parts of the fruit of summer cypress, 6 parts of Radix Glycyrrhizae, 20 parts of dandelion, 14 parts of Radix Paeoniae Alba, fourth
18 parts of glycol, 5 parts of trehalose, 50 parts of deionized water.
Comparative example 2
A kind of mosquito repellent, antipruritic, anti-inflammatory floral water, are prepared by the raw material of following parts by weight: 14 parts of the root of Dahurain angelica, 12 parts of honeysuckle,
8 parts of peppermint, 10 parts of perilla leaf, 10 parts of cloves, 16 parts of mulberry leaf, 9 parts of the fruit of summer cypress, 6 parts of Radix Glycyrrhizae, 15 parts of purslane, 20 parts of dandelion, fourth
18 parts of glycol, 5 parts of trehalose, 50 parts of deionized water.
Floral water made from embodiment 1-4 and comparative example 1-2 is subjected to following performance test:
Test example one, repelling effect test, carry out referring to GB/T17322.10-1998.
Subject is 90 people, is divided into six groups, every group of 15 people, respectively to 1-4 of the embodiment of the present invention and comparative example 1-2
Floral water tested.Everyone is blank control on the other hand, and the other hand presses 2 μ L/cm2Dose uniformity smear 5cm × 5cm
Dorsal area, wherein the position 4cm × 4cm, rest part tightly cover for exposure, and every 1h test is primary, until there is 1 mosquito
Until worm starts attack, effective mosquito repellent time is recorded, test result is as shown in table 1.It is learnt from table 1, flower produced by the present invention
The mosquito repellent time of dew is up to 9h or more, has good repelling effect.The repelling effect of comparative example is not so good as experiment of the invention
Group illustrates each ingredient synergistic effect of present invention composition floral water, has significant repelling effect, wherein the embodiment of the present invention 1
The floral water repelling effect being prepared is the most significant.
Table 1
Test example two, anti-inflammatory anti-itch test 1, test method: selection is by volunteer 180 of bite by mosquitos, by parallel control
Principle is randomly divided into 6 groups, every group of 30 people, respectively embodiment 1-4 group, comparative example 1-2 group.
After bite by mosquitos skin, floral water is taken uniformly to be applied at red swelling of the skin, smears dosage and adjusted according to Tumor size,
And record volunteer's number of cases (table 3) that antipruritic effect works in the curative effect (table 2) and 3min of floral water repellent antipruritic.2, curative effect
Evaluation:
It is effective: red swelling of the skin, heat, pain, symptom of itching rapid regression；
General: red swelling of the skin, heat, pain, symptom of itching mitigate；
Invalid: repellent antipruritic effect is unobvious or aggravates.
Table 2
Table 3
It is learnt from table 2 and table 3, floral water produced by the present invention has inflammation caused by bite by mosquitos, symptom of itching significant
Effect, antipruritic effect is rapid-action, and significant effect be better than comparative example 1 and comparative example 2, illustrate in floral water of the present invention it is each at
Divide synergistic effect, plays better antipruritic, anti-inflammatory effects.
Claims (6)
1. a kind of mosquito repellent, antipruritic, anti-inflammatory floral water, which is characterized in that be prepared by the raw material of following parts by weight: root of Dahurain angelica 7-14
Part, 6-12 parts of honeysuckle, 4-8 parts of peppermint, 5-10 parts of perilla leaf, 6-10 parts of cloves, 3-7 parts of frutus cnidii, 8-16 parts of mulberry leaf, the fruit of summer cypress
4-9 parts, 3-6 parts of Radix Glycyrrhizae, 6-15 parts of purslane, 10-20 parts of dandelion, 9-14 parts of Radix Paeoniae Alba, 10-18 parts of butanediol, trehalose 2-5
Part, 30-50 parts of deionized water.
2. a kind of mosquito repellent according to claim 1, antipruritic, anti-inflammatory floral water, which is characterized in that by the original of following parts by weight
Material is prepared: 8-12 parts of the root of Dahurain angelica, 7-10 parts of honeysuckle, 4-6 parts of peppermint, 6-9 parts of perilla leaf, 7-10 parts of cloves, frutus cnidii 4-6
Part, 10-15 parts of mulberry leaf, 5-8 parts of the fruit of summer cypress, 4-6 parts of Radix Glycyrrhizae, 8-14 parts of purslane, 12-18 parts of dandelion, 10-13 parts of Radix Paeoniae Alba,
12-16 parts of butanediol, 2-4 parts of trehalose, 35-45 parts of deionized water.
3. a kind of mosquito repellent according to claim 2, antipruritic, anti-inflammatory floral water, which is characterized in that by the original of following parts by weight
Material is prepared: 10 parts of the root of Dahurain angelica, 9 parts of honeysuckle, 5 parts of peppermint, 7.5 parts of perilla leaf, 8.5 parts of cloves, 5 parts of frutus cnidii, mulberry leaf 12.5
Part, 7 parts of the fruit of summer cypress, 5 parts of Radix Glycyrrhizae, 11 parts of purslane, 15 parts of dandelion, 12 parts of Radix Paeoniae Alba, 14 parts of butanediol, 3 parts of trehalose, go from
40 parts of sub- water.
4. the described in any item mosquito repellents of claim 1-3, antipruritic, anti-inflammatory floral water preparation method, which is characterized in that including with
Lower step:
(1) weigh by weight the root of Dahurain angelica, honeysuckle, peppermint, perilla leaf, cloves, frutus cnidii, mulberry leaf, the fruit of summer cypress, Radix Glycyrrhizae, purslane,
Dandelion, Radix Paeoniae Alba are put into pulverizer and crush acquisition coarse powder, be put into reaction vessel after coarse powder is taken out, then add thereto
The volume fraction for entering 5-10 times of parts by weight of coarse powder total weight is the ethyl alcohol of 70-80%, after impregnating 8-12h, at a temperature of 50-60 DEG C
Ultrasonic extraction 40-60min, then filters reaction system, collects filtrate, obtains filter residue；Again according to identical condition by filter residue
Secondary carry out ultrasonic extraction, filtering and collecting filter liquid discard filter residue, and the filtrate extracted twice is merged, and obtain crude extract；
(2) crude extract is subjected to vacuum distillation by Rotary Evaporators and gets rid of ethyl alcohol, obtain concentrate；
(3) concentrate is centrifuged under the revolving speed of 2000-3000r/min 5-10min, collects supernatant；By supernatant ultrafiltration
Film carries out ultrafiltration, and it is 1.10-1.20g/mL to get Chinese medicine extract that ultrafiltrate, which is concentrated under reduced pressure into relative density at 60 DEG C,；
(4) Chinese medicine extract is added in butanediol solution, trehalose is added under stirring conditions, in 300-500r/min's
20-40min is stirred under revolving speed, and mixture is made；
(5) it adds mixture in deionized water, is uniformly mixed, stand 1-4 weeks under the conditions of 4 DEG C, then pass through filter
Film filtering, obtains filtrate；
(6) filtrate obtains mosquito repellent, antipruritic, anti-inflammatory floral water through encapsulating, packaging.
5. mosquito repellent according to claim 4, antipruritic, anti-inflammatory floral water preparation method, which is characterized in that the step
(1) supersonic frequency in is 30-50kHz.
6. mosquito repellent according to claim 4, antipruritic, anti-inflammatory floral water preparation method, which is characterized in that the step
(3) molecular cut off of ultrafiltration membrane is not less than 10000 in.
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| CN201811339067.2A CN109481363A (en) | 2018-11-12 | 2018-11-12 | A kind of mosquito repellent, antipruritic, anti-inflammatory floral water and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111035728A (en) * | 2020-01-14 | 2020-04-21 | 长沙医学院 | VMP antidotal spray and preparation method thereof |
| CN111297774A (en) * | 2020-02-26 | 2020-06-19 | 中南大学湘雅医院 | Composition for repelling mosquitoes and preparation method thereof |
| CN113456549A (en) * | 2021-07-20 | 2021-10-01 | 广东桂格日化有限公司 | Mosquito repellent composition and toilet water containing same |
-
2018
- 2018-11-12 CN CN201811339067.2A patent/CN109481363A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111035728A (en) * | 2020-01-14 | 2020-04-21 | 长沙医学院 | VMP antidotal spray and preparation method thereof |
| CN111297774A (en) * | 2020-02-26 | 2020-06-19 | 中南大学湘雅医院 | Composition for repelling mosquitoes and preparation method thereof |
| CN113456549A (en) * | 2021-07-20 | 2021-10-01 | 广东桂格日化有限公司 | Mosquito repellent composition and toilet water containing same |
| CN113456549B (en) * | 2021-07-20 | 2023-01-31 | 广东桂格日化有限公司 | Mosquito repellent composition and toilet water containing same |
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Application publication date: 20190319 |