CN109481333A - A kind of astaxanthin EGF stoste and preparation method thereof - Google Patents
A kind of astaxanthin EGF stoste and preparation method thereof Download PDFInfo
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- CN109481333A CN109481333A CN201811528651.2A CN201811528651A CN109481333A CN 109481333 A CN109481333 A CN 109481333A CN 201811528651 A CN201811528651 A CN 201811528651A CN 109481333 A CN109481333 A CN 109481333A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of astaxanthin EGF stoste, the astaxanthin EGF stoste includes following part composition: astaxanthin；Butanediol, hamamelis extract, Radix Cynanchi Atrati extract；Methyl benzoate, Phenoxyethanol part；Lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, alanine, valine, isoleucine, leucine, tyrosine, phenylalanine；Butanediol；Glycine betaine, Natrulon H-10, aloe extract, oligopeptides -1；Polyacrylate cross-linked polymer -6；Hyaluronic acid, hydrolysis hyaluronic acid；Deionized water.Astaxanthin is directly prepared into astaxanthin EGF stoste by the present invention, astaxanthin after esterification is improved in terms of stability, absorption rate and waterproofness, convenient for absorption of human body, the EGF of needed by human body can be supplemented, promote the Proliferation, Differentiation of cell, astaxanthin can be supplemented again, plays the role of cooperateing with EGF, can effectively delay cell senescence to the aging of prevention and delaying skin.
Description
Technical field
The present invention relates to astaxanthin EGF stoste technical field, specially a kind of astaxanthin EGF stoste and preparation method thereof.
Background technique
Astaxanthin is that the mankind have found the strongest antioxidant of nature so far as a kind of natural function colorant.
Its singlet-oxygen quenching and the ability ratio p- carrotene high more than 10 for capturing free radical again, than then more than strong 100 times of vitamin E, resist
Oxidisability is ascorbic more than 6000 times.Due to its natural antioxidant activity, it can be effectively prevented skin light aging,
UVA and UVB is reduced to the injury of skin, delaying cell aging, reduction melanin deposition, enhances immunity of organisms；Shrimp is green simultaneously
Element has outstanding anti-inflammatory activity, has good treatment and prevention to act on the inflammation including cheilitis.
But existing astaxanthin has the following deficiencies: astaxanthin stability bottom, it is not easy to absorb benefit by body tissue
With.
Summary of the invention
(1) the technical issues of solving
In view of the deficiencies of the prior art, the present invention provides a kind of astaxanthin EGF stoste and preparation method thereof, shrimp is solved
Green element stability bottom, it is not easy to the problem of being absorbed and utilized by body tissue.
(2) technical solution
To achieve the above object, the invention provides the following technical scheme: a kind of astaxanthin EGF stoste, the astaxanthin EGF
Stoste includes following part composition: astaxanthin；Butanediol, hamamelis extract, Radix Cynanchi Atrati extract；Methyl benzoate, benzene
Oxyethanol part；Lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, alanine, figured silk fabrics
Propylhomoserin, isoleucine, leucine, tyrosine, phenylalanine；Butanediol；Glycine betaine, Natrulon H-10, aloe extract, oligopeptides-
1；Polyacrylate cross-linked polymer -6；Hyaluronic acid, hydrolysis hyaluronic acid；Deionized water.
Preferably, the step of astaxanthin is raw material extraction by haematococcus pluvialis, shrimp shell and crab shell and is obtained, preparation are as follows:
(1) haematococcus pluvialis of collection, shrimp shell and crab shell are cleaned into drying, is broken into fragment；
(2) then haematococcus pluvialis, shrimp shell and crab shell fragment are sent into edge runner, pulverizes into haematococcus pluvialis, shrimp shell
With crab shell powder, haematococcus pluvialis, shrimp shell and crab shell powder are uniformly mixed with glacial acetic acid, and carry out ice bath to mixture；
(3) it states that deionized water is added in mixed liquor and is placed in refiner then up and is homogenized；By resulting homogenate
It is concentrated, is dried to powder；
(4) then by above-mentioned powder loaded in supercritical extraction unit, astaxanthin extract is extracted to obtain.
Preferably, the deionized water is as obtained by the reverse osmosis+EDI technique preparation of RO.
Preferably, the astaxanthin EGF stoste prepares raw material and stocks up in sterile workshop, and the astaxanthin EGF is former
Liquid is prepared the quality of raw material and is measured with 100 parts by weight, and raw material includes 0.01-0.08 part of astaxanthin；Butanediol, North America gold
0.01-20 parts of thread prunus mume extract, Radix Cynanchi Atrati extract；0.01-20 parts of methyl benzoate, Phenoxyethanol；Lysine, histidine,
Arginine, aspartic acid, threonine, serine, glutamic acid, proline, alanine, valine, isoleucine, leucine, junket
0.01-5 parts of propylhomoserin, phenylalanine；0.01-10 parts of butanediol；Glycine betaine, Natrulon H-10, aloe extract, oligopeptides-
10.5-5 parts；- 60.1-0.5 part of polyacrylate cross-linked polymer；Hyaluronic acid, 0.01-0.5 part of hyaluronic acid of hydrolysis.
The present invention also provides a kind of astaxanthin EGF stoste preparation methods, include the next steps:
S1: weighing astaxanthin powder 1OOg first, and place it in IL extraction kettle, while 1OOmL ethyl alcohol conduct is added
Cosolvent；
S2: extraction parameters are set, and extraction kettle temperature is 65 DEG C, pressure 60MPa, and the flow of carbon dioxide is 10L/
H, separating still work temperature are 50 DEG C, pressure 3MPa, continuous dynamic extraction 2h, and kermesinus liquid is sporadically collected from separating still
Body；
S3: and then extracting solution is removed into cosolvent through being concentrated under reduced pressure, the esterification shrimp for obtaining the sticky mass of kermesinus is green
Element；
S4: being added in water-bath after being uniformly mixed according to a ratio, and in 65 DEG C -85 DEG C agitating and heating 15min -30min, uses
Citric acid regulating solution pH value obtains mixed liquor to 6.5-7.0；
S5: by 100 DEG C of sterilization 15min-20min of mixed liquor obtained in above-mentioned S4 to get astaxanthin EGF stoste.
(3) beneficial effect
The present invention provides a kind of astaxanthin EGF stoste and preparation method thereof, have it is following the utility model has the advantages that
Astaxanthin is directly prepared into astaxanthin EGF stoste by the present invention, the astaxanthin after esterification in stability, be absorbed and utilized
Improved in terms of rate and waterproofness, there is excellent antioxidant activity and anti-inflammatory efficacy, is convenient for absorption of human body, have both anti-
The functions such as wrinkle, sun-proof, anti-inflammatory, coloring；The present invention can supplement the EGF of needed by human body, promote the Proliferation, Differentiation of cell, while again
Astaxanthin can be supplemented, plays the role of cooperateing with EGF, can effectively delay cell senescence to prevention and delaying skin
Aging.
Detailed description of the invention
Fig. 1 is flowage structure schematic diagram of the present invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete
Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other
Embodiment shall fall within the protection scope of the present invention.
Refering to Figure 1, a kind of embodiment provided by the invention；A kind of astaxanthin EGF stoste, it is characterised in that: shrimp
Green element EGF stoste includes following part composition: astaxanthin；Butanediol, hamamelis extract, Radix Cynanchi Atrati extract；Benzoic acid
Methyl esters, Phenoxyethanol part；Lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, proline, third
Propylhomoserin, valine, isoleucine, leucine, tyrosine, phenylalanine；Butanediol；Glycine betaine, Natrulon H-10, aloe are extracted
Object, oligopeptides -1；Polyacrylate cross-linked polymer -6；Hyaluronic acid, hydrolysis hyaluronic acid；Deionized water, deionized water pass through
RO reverse osmosis+EDI technique preparation gained first passes through in RO reverse osmosis membrane removing water 99% or more impurity (including metal salt
Class), then ultra-pure deionized water is done with this water quality, at this moment ion exchange resin carries out in containing a small amount of electrolyte solution,
The i.e. comparable various anions and canons completely removed in water, and can all be rised appreciably using time and service life, water quality can reach
Very high purity can will become prone to control convenient for parameter using deionized water closer to design or ideal data, product quality；
Astaxanthin EGF stoste prepare raw material sterile workshop stock up, the astaxanthin EGF stoste prepare the quality of raw material with
The metering of 100 parts by weight, raw material includes 0.01-0.08 part of astaxanthin；Butanediol, hamamelis extract, radix cynanchi atrati are extracted
0.01-20 parts of object；0.01-20 parts of methyl benzoate, Phenoxyethanol；Lysine, histidine, arginine, aspartic acid, Soviet Union's ammonia
Acid, serine, glutamic acid, proline, alanine, valine, isoleucine, leucine, tyrosine, phenylalanine 0.01-5
Part；0.01-10 parts of butanediol；Glycine betaine, Natrulon H-10, aloe extract, 5 parts of oligopeptides-10.5-；Polyacrylate crosslinking
0.5 part of polymer-60.1-；Hyaluronic acid, hydrolysis 0.01-0.5 part of hyaluronic acid, astaxanthin by haematococcus pluvialis, shrimp shell and
The step of crab shell is that raw material is extracted and obtained, preparation are as follows: (1) haematococcus pluvialis of collection, shrimp shell and crab shell are cleaned into drying, are crushed
At the fragment of 10-20mm partial sizes；(2) then haematococcus pluvialis, shrimp shell and crab shell fragment are sent into edge runner, pulverizes granulating
Diameter is haematococcus pluvialis, shrimp shell and the crab shell powder of 5-8mm, and haematococcus pluvialis, shrimp shell and crab shell powder mix with glacial acetic acid
It is even, 10-20min of ice bath at-4-0 DEG C；(3) it states then up and deionized water is added in mixed liquor and is placed in refiner
It is homogenized 5-10min；By the concentration of resulting homogenate, it is dried to powder；(4) then above-mentioned powder is filled loaded on supercritical extract
In setting, the temperature and pressure of separation reactor I is 30-40 DEG C, 5-8MPa, the temperature and pressure of separation reactor I I is 30-40 DEG C,
20-25MPa, carbon dioxide flow rate are 10-15L/h, and extraction time obtains astaxanthin extract after being 0.5-1h.
A kind of astaxanthin EGF stoste preparation method, includes the next steps:
S1: weighing astaxanthin powder 1OOg first, and place it in IL extraction kettle, while 1OOmL ethyl alcohol conduct is added
Cosolvent；
S2: extraction parameters are set, and extraction kettle temperature is 65 DEG C, pressure 60MPa, and the flow of carbon dioxide is 10L/
H, separating still work temperature are 50 DEG C, pressure 3MPa, continuous dynamic extraction 2h, and kermesinus liquid is sporadically collected from separating still
Body；
S3: and then extracting solution is removed into cosolvent through being concentrated under reduced pressure, the esterification shrimp for obtaining the sticky mass of kermesinus is green
Element；
S4: being added in water-bath after being uniformly mixed according to a ratio, and in 65 DEG C -85 DEG C agitating and heating 15min -30min, uses
Citric acid regulating solution pH value obtains mixed liquor to 6.5-7.0；
S5: by 100 DEG C of sterilization 15min-20min of mixed liquor obtained in above-mentioned S4 to get astaxanthin EGF stoste.
Working principle: astaxanthin powder 1OOg is weighed first, and is placed it in IL extraction kettle, while 1OOmL second is added
Alcohol is as cosolvent；Extraction parameters are set, extraction kettle temperature is 65 DEG C, and the flow of pressure 60MPa, carbon dioxide are
10L/h, separating still work temperature are 50 DEG C, pressure 3MPa, continuous dynamic extraction 2h and sporadically collect from separating still dark red
Color liquid；Then extracting solution is removed into cosolvent through being concentrated under reduced pressure, obtains the esterification of astaxanthin of the sticky mass of kermesinus；It presses
Proportion is added in water-bath after mixing, in 65 DEG C of -85 DEG C of agitating and heating 15min--30min, uses citric acid regulating solution
PH value obtains mixed liquor to 6.5-7.0；By 100 DEG C of sterilization 15min-20min of mixed liquor obtained in above-mentioned S4 to get shrimp blueness
Plain EGF stoste.
It can to sum up obtain, astaxanthin is directly prepared into astaxanthin EGF stoste by the present invention, and the astaxanthin after esterification is in stabilization
Property, improved in terms of absorption rate and waterproofness, be convenient for absorption of human body, there is excellent antioxidant activity and anti-inflammatory function
Effect has both the functions such as crease-resistant, sun-proof, anti-inflammatory, coloring；The present invention can supplement the EGF of needed by human body, promote the proliferation point of cell
Change, while astaxanthin can be supplemented again, play the role of cooperateing with EGF, can effectively delay cell senescence to prevention and
The aging of delaying skin solves astaxanthin stability bottom, it is not easy to the problem of being absorbed and utilized by body tissue.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with
A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding
And modification, the scope of the present invention is defined by the appended.
Claims (5)
1. a kind of astaxanthin EGF stoste, it is characterised in that: the astaxanthin EGF stoste includes following part composition: astaxanthin；
Butanediol, hamamelis extract, Radix Cynanchi Atrati extract；Methyl benzoate, Phenoxyethanol part；Lysine, histidine, smart ammonia
Acid, aspartic acid, threonine, serine, glutamic acid, proline, alanine, valine, isoleucine, leucine, tyrosine,
Phenylalanine；Butanediol；Glycine betaine, Natrulon H-10, aloe extract, oligopeptides -1；Polyacrylate cross-linked polymer -6；Thoroughly
Bright matter acid, hydrolysis hyaluronic acid；Deionized water.
2. a kind of astaxanthin EGF stoste according to claim 1, it is characterised in that: the astaxanthin by haematococcus pluvialis,
The step of shrimp shell and crab shell are that raw material is extracted and obtained, preparation are as follows:
(1) haematococcus pluvialis of collection, shrimp shell and crab shell are cleaned into drying, is broken into fragment；
(2) then haematococcus pluvialis, shrimp shell and crab shell fragment are sent into edge runner, pulverizes into haematococcus pluvialis, shrimp shell and crab
Shell powder, haematococcus pluvialis, shrimp shell and crab shell powder are uniformly mixed with glacial acetic acid, and carry out ice bath to mixture；
(3) it states that deionized water is added in mixed liquor and is placed in refiner then up and is homogenized；Resulting homogenate is concentrated,
It is dried to powder；
(4) then by above-mentioned powder loaded in supercritical extraction unit, astaxanthin extract is extracted to obtain.
3. a kind of astaxanthin EGF stoste according to claim 1, it is characterised in that: the deionized water passes through RO reverse osmosis
+ EDI technique preparation gained thoroughly.
4. a kind of astaxanthin EGF stoste according to claim 1, it is characterised in that: the astaxanthin EGF stoste preparation is former
Material is stocked up in sterile workshop, and the astaxanthin EGF stoste is prepared the quality of raw material and measured with 100 parts by weight, former
Material includes 0.01-0.08 part of astaxanthin；Butanediol, hamamelis extract, 0.01-20 parts of Radix Cynanchi Atrati extract；Benzoic acid
0.01-20 parts of methyl esters, Phenoxyethanol；Lysine, histidine, arginine, aspartic acid, threonine, serine, glutamic acid, dried meat
Propylhomoserin, alanine, valine, isoleucine, leucine, tyrosine, 0.01-5 parts of phenylalanine；0.01-10 parts of butanediol；
Glycine betaine, Natrulon H-10, aloe extract, 5 parts of oligopeptides-10.5-；- 60.1-0.5 part of polyacrylate cross-linked polymer；
Hyaluronic acid, 0.01-0.5 part of hyaluronic acid of hydrolysis.
5. a kind of astaxanthin EGF stoste preparation method according to claim 1, it is characterised in that: the following steps are included:
S1: weighing astaxanthin powder 1OOg first, and place it in IL extraction kettle, while 1OOmL ethyl alcohol is added as molten altogether
Agent；
S2: extraction parameters are set, and extraction kettle temperature is 65 DEG C, pressure 60MPa, and the flow of carbon dioxide is 10L/h, point
It is 50 DEG C from kettle work temperature, pressure 3MPa, continuous dynamic extraction 2h sporadically collect dark red solution from separating still；
S3: and then extracting solution is removed into cosolvent through being concentrated under reduced pressure, obtain the esterification of astaxanthin of the sticky mass of kermesinus；
S4: being added in water-bath after being uniformly mixed according to a ratio, and in 65 DEG C -85 DEG C agitating and heating 15min -30min, uses lemon
Acid-conditioning solution pH value obtains mixed liquor to 6.5-7.0；
S5: by 100 DEG C of sterilization 15min-20min of mixed liquor obtained in above-mentioned S4 to get astaxanthin EGF stoste.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811528651.2A CN109481333A (en) | 2018-12-13 | 2018-12-13 | A kind of astaxanthin EGF stoste and preparation method thereof |
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| CN201811528651.2A CN109481333A (en) | 2018-12-13 | 2018-12-13 | A kind of astaxanthin EGF stoste and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005523323A (en) * | 2002-04-22 | 2005-08-04 | インダストリアル リサーチ リミティド | Improvements in or relating to separation technology |
| CN101691348A (en) * | 2009-09-07 | 2010-04-07 | 浙江大学 | Method for extracting astaxanthin from haematococcus pluvialis |
| CN104557649A (en) * | 2014-12-25 | 2015-04-29 | 青岛文创科技有限公司 | Method for extracting astaxanthin |
| CN107823079A (en) * | 2017-11-03 | 2018-03-23 | 烟台康达尔药业有限公司 | A kind of sea cucumber EGF composition skin-care cosmetics and preparation method thereof |
-
2018
- 2018-12-13 CN CN201811528651.2A patent/CN109481333A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005523323A (en) * | 2002-04-22 | 2005-08-04 | インダストリアル リサーチ リミティド | Improvements in or relating to separation technology |
| CN101691348A (en) * | 2009-09-07 | 2010-04-07 | 浙江大学 | Method for extracting astaxanthin from haematococcus pluvialis |
| CN104557649A (en) * | 2014-12-25 | 2015-04-29 | 青岛文创科技有限公司 | Method for extracting astaxanthin |
| CN107823079A (en) * | 2017-11-03 | 2018-03-23 | 烟台康达尔药业有限公司 | A kind of sea cucumber EGF composition skin-care cosmetics and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 范荣新: "虾青素的性质与开发", 《海湖盐与化工》 * |
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Application publication date: 20190319 |