CN109464749A - Neutron capture treatment system - Google Patents
Neutron capture treatment system Download PDFInfo
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- CN109464749A CN109464749A CN201710799364.4A CN201710799364A CN109464749A CN 109464749 A CN109464749 A CN 109464749A CN 201710799364 A CN201710799364 A CN 201710799364A CN 109464749 A CN109464749 A CN 109464749A
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N5/1028—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy using radiation sources applied onto the body
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1042—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head
- A61N5/1045—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy with spatial modulation of the radiation beam within the treatment head using a multi-leaf collimator, e.g. for intensity modulated radiation therapy or IMRT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1048—Monitoring, verifying, controlling systems and methods
- A61N5/1064—Monitoring, verifying, controlling systems and methods for adjusting radiation treatment in response to monitoring
- A61N5/1065—Beam adjustment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1077—Beam delivery systems
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- A—HUMAN NECESSITIES
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- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N5/1001—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy using radiation sources introduced into or applied onto the body; brachytherapy
- A61N2005/1019—Sources therefor
- A61N2005/1022—Generators, e.g. X-ray tubes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/1087—Ions; Protons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1094—Shielding, protecting against radiation
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- A—HUMAN NECESSITIES
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- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1097—Means for immobilizing the patient
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The present invention provides a kind of neutron capture treatment system, can effectively utilize space, while treating to multiple patients, and the route without excessively extending beam transmission, is lost smaller.Neutron capture treatment system of the invention, including the accelerator for carrying out accelerating to generate charged particle beam to charged particle, by the Transport of Charged Particle Beams of accelerator generation to the beam transport part of neutron beam generating unit, generate the neutron beam generating unit for the treatment of neutron beam, neutron beam generating unit includes first, second and third neutron beam generating unit, beam transport part includes the first transport part connecting with accelerator, switch the beam direction switch of charged particle beam direction of travel and charged particle beam is transferred to first from beam direction switch respectively, second, the second of third neutron beam generating unit, third, 4th transport part, first, third and fourth transport part, two definition therein, first plane, first and second transport parts define the second plane, first plane and the second plane difference.
Description
Technical field
The present invention relates to a kind of irradiation with radiation system more particularly to a kind of neutron capture treatment systems.
Background technique
As the radiation cures such as the development of atomics, such as cobalt 60, linear accelerator, electron beam have become cancer
One of the main means of disease treatment.However conventional photonic or electronic therapy are limited by radioactive ray physical condition itself, are being killed
While dead tumour cell, normal tissue a large amount of in beam approach can also be damaged；Additionally, due to tumour cell to putting
The difference of radiation-sensitive degree, traditional radiation therapy is for relatively having the malignant tumour of radiation resistance (such as: multirow glioblast
Tumor (glioblastoma multiforme), melanocytoma (melanoma)) treatment effect it is often bad.
Target therapy in order to reduce the radiation injury of tumour surrounding normal tissue, in chemotherapy (chemotherapy)
Concept is just applied in radiation cure；And it is directed to the tumour cell of radiation resistance, also actively development has high phase at present
To the radiation source of biological effect (relative biological effectiveness, RBE), as proton therapeutic, heavy particle are controlled
Treatment, neutron capture treatment etc..Wherein, neutron capture treatment is to combine above two concept, if boron neutron capture is treated, by
Boracic drug gathers in the specificity of tumour cell, and accurately neutron beam regulates and controls for cooperation, provides more better than conventional radiation
Treatment of cancer selection.
Various radioactive ray can be generated during radiation cure, as boron neutron capture therapeutic process generates low energy to high energy
Neutron, photon, these radioactive ray may cause different degrees of damage to human normal tissue.Therefore it is led in radiation cure
Domain, how to reduce while reaching effective treatment is to the radiation pollution of external environment, medical worker or patient's normal tissue
One particularly important project.Meanwhile multiple patients cannot be treated simultaneously in the treatment of accelerator boron neutron capture at present, or
Multiple exposure cell's layouts are unreasonable, and the transmission path of charged particle beam is longer, generates loss.
Therefore, it is necessary to propose the new technical solution of one kind to solve the above problems.
Summary of the invention
To solve the above-mentioned problems, one aspect of the present invention provides a kind of neutron capture treatment system, including accelerator, penetrates
Beam transport part, neutron beam generating unit, the accelerator carry out charged particle to accelerate to generate charged particle beam, the beam transmission
The Transport of Charged Particle Beams that portion generates the accelerator to the neutron beam generating unit, the neutron beam generating unit generates treatment
With neutron beam, the neutron beam generating unit includes that the first neutron beam generating unit, the second neutron beam generating unit and third neutron beam are raw
At portion, the beam transport part includes the first transport part connecting with the accelerator, switching charged particle beam direction of travel
Beam direction switch and charged particle beam is transferred to described first, second, third from the beam direction switch respectively
Second, third and the 4th transport part of neutron beam generating unit, described first, the third and fourth transport part two definition therein the
One plane, first and second transport part define the second plane, first plane and the second plane difference.Using such
Arrangement mode can be effectively utilized space, while treat to multiple patients, and the line without excessively extending beam transmission
Road is lost smaller.
Preferably, first transport part is transmitted along the x axis, and the third, the transmission direction of the 4th transport part are in XY
In plane and formation is greater than 0 degree of angle.Further, second transport part is transmitted along Z-direction, the third, the 4th
The transmission direction of transport part and the transmission direction of first transport part are Y-shaped.
Preferably as another kind, the neutron capture treatment system further includes instrument table, the neutron beam generating unit packet
Target, beam-shaping body and collimator are included, the target is arranged between the beam transport part and the beam-shaping body, institute
The charged particle beam for stating accelerator generation is irradiated to the target through the beam transport part and acts in generation with the target
Son, the neutron of the generation passes sequentially through the beam-shaping body and collimator forms treatment neutron beam and irradiates and controls to described
Treat the patient on platform.
Further, the beam-shaping body includes reflector, slow body, thermal neutron absorber, radiation shield and penetrates
Beam outlet, the slow body is by from the neutron degradation that the target generates to epithermal neutron energy area, described in the reflector encirclement
Slow body and the neutron that will deviate from improve epithermal neutron intensity of beam, the thermal neutron absorber use back to the slow body
Multi-dose was caused with shallow-layer normal tissue when absorbing thermal neutron to avoid treatment, the radiation shield surrounds the beam
Outlet is arranged in the reflector rear portion and is used to shield the normal tissue dose of the neutron leaked and photon to reduce non-irradiated area,
The collimator, which is arranged, goes out metastomium in the beam to converge neutron beam, and radiation shield is arranged between the patient and beam outlet
Device is covered to shield radiation of the beam for exporting out from the beam to patient's normal tissue.The beam transport part have pair
The vacuum tube that charged particle beam is accelerated or transmitted, the vacuum tube protrude into the beam-shaping along charged particle beam direction
Body, and the reflector and slow body are sequentially passed through, the target is arranged in described slow in vivo and positioned at the vacuum tube
End.
Further, the boron neutron capture treatment system further includes exposure cell, and the patient on the instrument table is described
The treatment of neutron beam irradiation is carried out in exposure cell, the exposure cell includes and the first, second, third neutron beam generating portion
Not corresponding first, second, and third exposure cell, first, second, third exposure cell respectively along it is described second, third,
The transmission direction of four transport parts is arranged.
Further, the boron neutron capture treatment system further includes that charged particle beam generates room, the charged particle
The room Shu Shengcheng accommodates the accelerator and at least partly described beam transport part.It includes accelerator that the charged particle beam, which generates room,
Room and beam transfer chamber, first transport part extend to the beam transfer chamber from the accelerator room, it is described second, third
At least part of neutron beam generating unit is embedded in the partition wall of described second, third exposure cell and beam transfer chamber, and described the
Three, the 4th transport part extends to second, third described neutron beam generating unit from the beam transfer chamber, and first neutron beam is raw
It is located in first exposure cell at portion, second transport part passes through floor from the beam transfer chamber and extends to described first
Exposure cell, the boron neutron capture treatment system further includes preparation room and control room.
As it is another preferably, the first, second, third neutron beam generating unit respectively along it is described second, third, the
The transmission directions of four transport parts is arranged, the neutron beam direction that the first, second, third neutron beam generating unit generates respectively with institute
State second, third, the transmission direction of the 4th transport part it is identical so that second, third described neutron beam generating unit generate neutron
In the same plane, the neutron beam direction that the first neutron beam generating unit generates is vertical with the plane by Shu Fangxiang.
Preferably as another kind, the beam direction switch includes the first, second beam direction switch, described to penetrate
Beam transport part further includes the 5th transport part for connecting the first, second beam direction switch, the second transport part connection
The first beam direction switch and the first neutron beam generating unit, the third transport part connect the second beam side
To switch and the second neutron beam generating unit, the 4th transport part connects the second beam direction switch and described
Third neutron beam generating unit.
Further, the first, second beam direction switch includes the deflection electricity for deflecting charged particle beam direction
Magnet and the switch electromagnet for controlling charged particle beam direction of travel, the boron neutron capture treatment system further includes for controlling
The beam trap of the output confirmation of charged particle beam is carried out before treating, the first or second beam direction switch is guided into described
Beam trap, described first, second, third, fourth, the 5th transport part include beam adjustment section for charged particle beam,
It is described second, third, the 4th transport part include current monitor and charged particle beam scanner section.
Neutron capture treatment system of the invention can be effectively utilized space, while treat to multiple patients, and
Without excessively extending the route of beam transmission, it is lost smaller.
Detailed description of the invention
Fig. 1 is the neutron capture treatment system structural schematic diagram in the embodiment of the present invention；
Fig. 2 is schematic layout pattern of the neutron capture treatment system in the embodiment of the present invention in X/Y plane；
Fig. 3 is schematic diagram of the Fig. 2 in A-A section.
Specific embodiment
The embodiment of the present invention is described in further detail with reference to the accompanying drawing, to enable those skilled in the art's reference
Specification word can be implemented accordingly.Set the direction of charged particle beam P of projecting aftermentioned accelerator as X-axis, will be with
The orthogonal direction in direction for the charged particle beam P that accelerator projects as Y-axis, using the direction vertical relative to ground as Z axis
XYZ coordinate system (referring to figs. 2 and 3), and in the explanation of the positional relationship in each constitutive requirements use X, Y, Z.
Such as Fig. 1, the neutron capture treatment system in the present embodiment is preferably boron neutron capture treatment system 100, boron neutron
Capture treatment system 100 is the device that treatment of cancer is carried out using boron neutron capture therapy.Boron neutron capture therapy passes through to note
The patient 200 for penetrating boron (B-10) irradiates neutron beam N to carry out treatment of cancer, and patient 200 takes or inject boracic (B-10) medicine
It after object, is gathered in tumour cell M to boracic drug selectivity, then thermal neutron is caught with height using boracic (B-10) drug
The characteristic for obtaining section, by10B(n,α)7Li neutron capture and nuclear fission reaction generate4He and7Two heavy burden charged particle of Li.Two lotuses
The average energy of charged particle is about 2.33MeV, and there is High Linear to shift (Linear Energy Transfer, LET), short range
Feature, the linear energy transfer of the short particle of α and range are respectively 150keV/ μm, 8 μm, and7Li heavy burden particle is then 175keV/ μ
M, 5 μm, the integrated range of two particle is approximately equivalent to a cell size, therefore the radiation injury for caused by organism can be confined to
Cell level just can achieve the purpose that tumour cell is killed in part under the premise of normal tissue does not cause too major injury.
Boron neutron capture treatment system 100 includes accelerator 10, beam transport part 20, neutron beam generating unit 30 and instrument table
40.Accelerator 10 accelerates charged particle (such as proton, deuteron), generates the charged particle beam P such as proton beam；Beam passes
The charged particle beam P that accelerator 10 generates is transmitted to neutron beam generating unit 30 by defeated portion 20；Neutron beam generating unit 30 generates treatment
With neutron beam N and irradiate the patient 200 on instrument table 40.
Neutron beam generating unit 30 includes target T, beam-shaping body 31, collimator 32, the charged particle that accelerator 10 generates
Beam P is irradiated to target T and acts on target T through beam transport part 20 generates neutron, and the neutron of generation passes sequentially through beam-shaping
Body 31 and collimator 32 form treatment neutron beam N and irradiate the patient 200 on instrument table 40.Target T is preferably metallic target
Material.According to required neutron yield rate and energy, the available materialization for accelerating charged particle energy and size of current, metal targets
The characteristics such as property select suitable nuclear reaction, and the nuclear reaction being often discussed has7Li(p,n)7Be and9Be(p,n)9B, both are anti-
It should be all the endothermic reaction.The energy threshold of two kinds of nuclear reactions is respectively 1.881MeV and 2.055MeV, since boron neutron capture is controlled
The ideal neutron source for the treatment of is the epithermal neutron of keV energy grade, if being theoretically only slightly taller than the proton bombardment of threshold values using energy
Lithium metal target can produce the neutron of opposite low energy, and clinic can be used for by being not required to too many slow handle, however lithium metal (Li)
It is not high with two kinds of targets of beryllium metal (Be) and the proton-effect section of threshold values energy, to generate sufficiently large neutron flux, usually
The proton of higher-energy is selected to cause nuclear reaction.Ideal target should have the neutron energy distribution of high neutron yield rate, generation
Radiation generation, the cheap easily operated and resistance to height of safety are worn by force close to epithermal neutron energy area (will be described in more detail below), without too many
The characteristics such as temperature, but actually and can not find and meet required nuclear reaction.It is well known to those skilled in the art, target T
It can be made of the metal material except Li, Be, such as be formed by Ta or W and its alloy etc..Accelerator 10 can be straight line and add
Fast device, cyclotron, synchrotron, synchrocyclotron.
Beam-shaping body 31 can adjust the beam quality for the neutron beam N that charged particle beam P and target T effect generates, quasi-
Straight device 32 makes neutron beam N targeting with higher during being treated to converge neutron beam N.Beam-shaping body
31 further comprise reflector 311, slow body 312, thermal neutron absorber 313, radiation shield 314 and beam outlet 315, band
The neutron that electrochondria beamlet P and target T effect generates other than epithermal neutron meets treatment needs, is needed since power spectrum is very wide
Other kinds of neutron is reduced as far as possible and photon content damages to avoid to operator or patient, therefore from target
The neutron that T comes out needs that fast neutron energy therein (> 40keV) is adjusted to epithermal neutron energy area by slow body 312
(0.5eV-40keV) and as far as possible reduce thermal neutron (< 0.5eV), slow body 312 by with fast neutron action section it is big, it is superthermal in
The small material of sub- action section is made, and in the present embodiment, slow body 312 is by D2O、AlF3、Fluental、CaF2、Li2CO3、MgF2
And Al2O3At least one of be made；Reflector 311 surrounds slow body 312, and passes through during slow body 312 spreads around
Son is reflected back neutron beam N to improve the utilization rate of neutron, by being made with the strong material of neutron reflection ability, the present embodiment
In, reflector 311 is made of at least one of Pb or Ni；There is a thermal neutron absorber 313 at slow 312 rear portion of body, by with
The big material of thermal neutron action section is made, and in the present embodiment, thermal neutron absorber 313 is made of Li-6, thermal neutron absorber
313 reduce the content of thermal neutron in neutron beam N for absorbing thermal neutron across slow body 312, when avoiding treating and shallow-layer
Normal tissue caused multi-dose；Radiation shield 314 around 315 setting of beam outlet at reflector rear portion, for shield from
The neutron and photon that beam outlet 315 is leaked with outer portion, the material of radiation shield 314 includes photon shielding material and neutron
At least one of shielding material, in the present embodiment, the material of radiation shield 314 include photon shielding material lead (Pb) and in
Sub- shielding material polyethylene (PE).It is appreciated that beam-shaping body 31 can also have other constructions, as long as can be treated
Required epithermal neutron beam.Collimator 32 setting beam export 315 rear portions, from collimator 32 come out epithermal neutron beam to
Patient 200 is irradiated, and is slowly that thermal neutron reaches tumour cell M after shallow-layer normal tissue, it will be understood that collimator 32 can also
To cancel or be replaced by other structures, neutron beam comes out from beam outlet 315 directly to be irradiated to patient 200.In the present embodiment, suffer from
It is also provided with radiation shield device 50 between person 200 and beam outlet 315, shields the beam come out from beam outlet 315 to trouble
The radiation of person's normal tissue, it will be understood that radiation shield device 50 can also be not provided with.Target T is arranged in beam transport part 20
Between beam-shaping body 31, beam transport part 20 has the vacuum tube C that charged particle beam P is accelerated or transmitted, this reality
It applies in example, vacuum tube C protrudes into beam-shaping body 31 along the direction charged particle beam P, and sequentially passes through reflector 311 and slow body
The end in slow body 312 and being located at vacuum tube C is arranged in 312, target T, to obtain preferable neutron beam quality.It can manage
Solution, target can have other set-up modes, can also be with respect to accelerator or beam-shaping body it is movable, change target to facilitate
Or make charged particle beam and target stepless action.
In conjunction with Fig. 2 and Fig. 3, boron neutron capture treatment system 100 is integrally provided in the space of two floor L1 and L2, boron neutron
Capture treatment system 100 further includes that exposure cell 101 (101A, 101B, 101C) and charged particle beam generate room 102, instrument table 40
On patient 200 treatment of neutron beam N irradiation is carried out in exposure cell 101 (101A, 101B, 101C), charged particle beam generates
Room 102 accommodates accelerator 10 and at least partly beam transport part 20.Neutron beam generating unit 30 can have one or more, to generate
One or more treatment neutron beam N, beam transport part 20 is selectively to one or several 30 transmission belts of neutron beam generating unit
Electrochondria beamlet P transmits charged particle beam P to multiple neutron beam generating units 30 simultaneously, and each neutron beam generating unit 30 is one corresponding
Exposure cell 101.Respectively there are 3, respectively neutron beam generating unit 30A, 30B, 30C in neutron beam generating unit and exposure cell in the present embodiment
With exposure cell 101A, 101B, 101C.Beam transport part 20 includes: the first transport part 21, is connect with accelerator 10；First, second
Beam direction switch 22,23 switches the direction of travel of charged particle beam P；Second transport part 24 connects the first, second beam
Direction switcher 22,23；Third, the four, the 5th transport part 25A, 25B, 25C, respectively by charged particle beam P from the first beam side
It is transferred to neutron beam generating unit 30A, 30B, 30C to switch 22 or the second beam direction switch 23, the neutron beam N of generation is again
The patient into exposure cell 101A, 101B, 101C is irradiated respectively.Third transport part 25A the first beam direction of connection switch 22
And neutron beam generating unit 30A, the 4th transport part 25B the second beam direction of connection switch 23 and neutron beam generating unit 30B, the 5th
Transport part 25C the second beam direction of connection switch 23 and neutron beam generating unit 30C.That is, the first transport part 21 is in the first beam
The second transport part 24 and third transport part 25A are branched into direction switcher 22, the second transport part 24 is again in the second beam direction
The 4th transport part 25B and the 5th transport part 25C is branched into switch 23.First, second transport part 21,24 passes along the x axis
It is defeated, third transport part 25A along Z-direction transmit, the transmission direction of the four, the 5th transport part 25B, 25C in X/Y plane and with
The transmission direction of first, second transport part 21,24 is Y-shaped, neutron beam generating unit 30A, 30B, 30C and corresponding exposure cell
101A, 101B, 101C are arranged along third, the transmission direction of the four, the 5th transport part 25A, 25B, 25C respectively, the neutron of generation
The direction beam N is identical as the transmission direction of third, the four, the 5th transport part 25A, 25B, 25C respectively, thus neutron beam generating unit
In the same plane, the neutron beam direction and the plane that neutron beam generating unit 30A is generated are hung down in the neutron beam direction that 30B, 30C are generated
Directly.Using such arrangement mode, space can be effectively utilized, while multiple patients are treated, and does not prolong excessively
The route of long beam transmission, is lost smaller.It is appreciated that the direction neutron beam N that neutron beam generating unit 30A (30B, 30C) is generated
It can also be different with the transmission direction of third (the four, the 5th) transport part 25A (25B, 25C)；First, second transport part 21,24
Transmission direction can also be different, the second transport part 24 can also cancel, and only have a beam direction switch, by beam point
Branch is 2 and 2 or more hops；The transmission direction of four, the 5th transport part 25B, 25C and the transmission of the first transport part 21
The Y-shaped that direction is formed, is also possible to the deformation of " Y ", such as the transmission direction of the 4th transport part 25B or the 5th transport part 25C
It is identical as the transmission direction of the first transport part 21, transmission direction and the first transport part 21 of the four, the 5th transport part 25B, 25C
Transmission direction can also be in other shapes, such as T-shape or arrowhead-shaped, as long as the transmission direction of the four, the 5th transport part 25B, 25C
The angle greater than 0 degree is formed in X/Y plane；The transmission direction of four, the 5th transport part 25B, 25C is also not necessarily limited to X/Y plane,
The transmission direction of third transport part 25A may not be along Z axis, as long as the transmission direction of the 4th transport part 25B, the 5th transport part
The transmission direction of 25C and the transmission direction of the first transport part 21 two therein, first biographies interior in same plane (the first plane)
The transmission direction in defeated portion 21 and the transmission direction of third transport part 25A are also interior in same plane (the second plane), and the first plane
It is different with the second plane；Third transport part 25A, neutron beam generating unit 30A and exposure cell 101A can also cancel, and only have in this way
Beam transmission in X/Y plane.
First, second beam direction switch 22,23 includes the deflection electromagnet for deflecting the direction charged particle beam P and control
The switch electromagnet of charged particle beam P direction of travel processed, boron neutron capture treatment system 100 can also include beam trap
(not shown), the before the treatment equal output confirmation for carrying out charged particle beam P, first or second beam direction switch 22,23 energy
Charged particle beam P is enough set to be detached from regular track and guide beam trap into.
First transport part 21, the second transport part 24 and third, the four, the 5th transport part 25A, 25B, 25C are by vacuum tube C
Construction, can be connected respectively by multiple sub- transport parts and be formed, and the transmission direction of multiple sub- transport parts can be the same or different,
The deflection of beam transmission direction, described first, second, third, fourth, the 5th transport part are such as carried out by deflection electromagnet
21,24, the transmission direction of 25A, 25B, 25C can be the transmission direction of its any sub- transport part, the first plane of above-mentioned formation
And second plane be the plane formed between the sub- transport part being connected directly with beam direction switch；It can also respectively include using
In the beam adjustment section (not shown) of charged particle beam P, beam adjustment section includes the level for adjusting the axis of charged particle beam P
Type diverter and horizontal vertical type diverter, the quadrupole electromagnet of diverging for inhibiting charged particle beam P and for charging
Four-way cutter of the shaping of particle beams P etc..Third, the four, the 5th transport part 25A, 25B, 25C can include electric current as needed
Monitor (not shown) and charged particle beam scanner section (not shown).Current monitor the real time measure is irradiated in the band electrochondria of target T
The current value (that is, charge, exposure dose rate) of beamlet P.Charged particle beam scanner section scans charged particle beam P, carries out band electrochondria
Beamlet P is controlled relative to the irradiation of target T, such as controls irradiation position of the charged particle beam P relative to target T.
It may include accelerator room 1021 and beam transfer chamber 1022, accelerator room 1021 that charged particle beam, which generates room 102,
It is two layers, accelerator 10 extends to L1 from L2.Beam transfer chamber 1022 is located at L2, and the first transport part 21 is prolonged from accelerator room 1021
Reach beam transfer chamber 1022.Exposure cell 101B, 101C are located at L2, and exposure cell 101A is located at L1.L1 is at L2 in the present embodiment
Side, the i.e. floor of L2 are the ceiling of L1, it is possible to understand that, or opposite configuration.The material of floor (ceiling) S can be with
For the concrete or boracic baryte of thickness 0.5m or more.Exposure cell 101A, 101B, 101C and beam transfer chamber 1022
Has the shielding space surrounded by shielding wall W1, shielding wall W1 can be the boracic barite of thickness 1m or more, density 3g/c.c.
Concrete wall, including separate beam transfer chamber 1022 and exposure cell 101B, 101C the first compartment shield wall W2 and L1 every
It opens the second compartment shield wall W3 of accelerator room 1021 and beam transfer chamber 1022, separate accelerator room 1021 and exposure cell in L2
The third compartment shield wall W4 of 101A.Accelerator room 1021 is by the concrete wall W and the second compartment shield wall with a thickness of 1m or more
W3, third compartment shield wall W4 are surrounded.At least part of neutron beam generating unit 30B, 30C is embedded in the first compartment shield wall
W2, the four, the 5th transport part 25B, 25C extend to neutron beam generating unit 30B, 30C from beam transfer chamber 1022；Neutron beam generates
Portion 30A is located in exposure cell 101A, and third transport part 25A passes through floor S from beam transfer chamber 1022 and extends to exposure cell 101A.
Exposure cell 101A, 101B, 101C are respectively provided with shield door D1, D2, D3 for instrument table 40 and doctor's discrepancy, accelerator room 1021
Shield door D4, D5 that accelerator 10 is safeguarded in disengaging accelerator Room 1021, beam transfer chamber are respectively provided in L1 and L2
1022 have the shield door D6 safeguarded from the disengaging beam transfer chamber 1022 of accelerator room 1021 to beam transport part 20, shielding
Door D6 is arranged on the second compartment shield wall W3.The indoor of exposure cell 101A, 101B, 101C also has inner shield wall W5, with shape
At the labyrinth type channel exported from shield door D1, D2, D3 to beam, radiation when shield door D1, D2, D3 being prevented to be opened accidentally
Direct irradiation can be set in different positions according to the different layout inner shield wall W5 of exposure cell, in interior shielding wall W5 and screen
The shield door D7 that can also be arranged inside exposure cell between wall W1 or third compartment shield wall W4 is covered, is formed in and carries out neutron beam photograph
Penetrate secondary protection when treatment.Inner shield wall W5 can be the boracic barite coagulation that thickness 0.5m or more, density are 3g/c.c.
Soil wall；Shield door D1, D2, D3, D4, D5, D6, D7 can be made of two layers of independent main shield door D and secondary shield door D ' or
It is only made of, can be determined according to practical situation, main shield door D can be identical material main shield door D or secondary shield door D '
With a thickness of the PE or baryte or lead of the boracic of 0.5m or more, density 6g/c.c., secondary shield door D ' can be identical material
The PE or baryte or lead of the boracic with a thickness of 0.2m or more, density 6g/c.c. of material.In the present embodiment, shield door
D1, D4, D5, D6 are made of main shield door D and secondary shield door D ', and shield door D1, D2, D3 only include main shield door D, shield door D7
It only include time shield door D '.Shielding wall and shield door form shielding space, inhibit radioactive ray from exposure cell 101A, 101B, 101C
Indoor and radioactive ray are invaded with the outdoor of beam transfer chamber 1022, and outdoor phenomenon is emitted to from interior.In the present embodiment, every
The the second compartment shield wall W3 for opening accelerator room 1021 and beam transfer chamber 1022 is arranged in accelerator 10 and the first beam direction
Between switch 22, i.e. the first transport part 21 passes through the second compartment shield wall W3, it will be understood that the second compartment shield wall W3 and screen
Covering a D6 can cancel, and also can be set in other positions, as between the first, second beam direction switch 22,23 or second
Between beam direction switch 23 and neutron beam generating unit 30B, 30C；Or in the second compartment shield wall W3 and the first compartment shield
Additional compartment shield wall and shield door are set between wall W2.That is, being arranged between neutron beam generating unit and accelerator
Shielding wall, when accelerator overhauls and safeguards, operator is from the neutron that leaks from neutron beam generating unit and other radiation
Irradiation, while reducing reaction of the accelerator by neutron activation.
Neutron and the leakage of other radiation are be easy to cause by the place that component or element pass through in shielding wall or floor, such as
In the present embodiment, neutron beam generating unit 30B, 30C passes through the first compartment shield wall W2, the first transport part 21 passes through the second panel superheater
Wall W3, third transport part 25A are covered across floor S, are penetrated in the first compartment shield wall W2, the second compartment shield wall W3, floor S direction
The portion that the side of beam transmission direction upstream is passed through by neutron beam generating unit 30B, 30C, the first transport part 21, third transport part 25A
The first shield 60, secondary shielding body 70 and third shield 80 can be respectively set in position.First shield 60 covers neutron beam
Generating unit 30B, 30C towards accelerator end and connect with the first compartment shield wall W2 around neutron beam generating unit 30B, 30C
Touching, the neutron that prevents from overflowing from the beam-shaping body of neutron beam generating unit 30B, 30C or reflect enter accelerator room 1021 and penetrate
Beam transfer chamber 1022, the four, the 5th transport part 25B, 25C pass through the first shield 60 and reach neutron beam generating unit 30B, 30C
Target T.Secondary shielding body 70 is contacted with the second compartment shield wall W3 around the first transport part 21, is prevented from beam transport part 20
It overflows or the neutron of reflection enters accelerator room 1021, the first transport part 21 passes through secondary shielding body 70 and the second compartment shield wall
W3 reaches the first beam direction switch 22.Floor S contact around third shield 80 and third transport part 25A, prevent from
Exposure cell 101A overflows or the neutron of reflection enters beam transfer chamber 1022, and third transport part 25A passes through 80 He of third shield
Floor S reaches neutron beam generating unit 30A.The material of first shield 60, secondary shielding body 70 and third shield 80 can be
The PE or baryte or lead of boracic.
First, second beam direction switch 22,23 is surrounded by shielding case 26 respectively, prevents from letting out from beam direction switch
Neutron and other radiation are leaked, the material of shielding case 26 can be the PE or baryte or lead of boracic.It is appreciated that the
One, the second beam direction switch 22,23 can also be surrounded integrally by a shielding case 26；The other parts of beam transport part,
It such as vacuum tube, can also be surrounded by shielding case, prevent neutron and other radiation from revealing from beam transport part.
Boron neutron capture treatment system 100 can also include preparation room, control room and other for adjuvant treatment spaces,
Each exposure cell can configure a preparation room, for be irradiated treat before immobilized patients to instrument table, inject boron medicine, control
The preparations such as plan simulation are treated, interface channel is set between preparation room and exposure cell, and preparation is after the completion directly by patient
Push-in exposure cell controls it automatically into exposure cell by control mechanism by track, and preparation room and interface channel are also by shielding wall
Closing, preparation room also have shield door.Control room is irradiated for controlling accelerator, beam transport part, instrument table etc. to entire
Cheng Jinhang control and management, administrative staff can also monitor multiple exposure cells simultaneously in control room.
It is appreciated that shielding wall (including concrete wall W), shield door, shield, the shielding case in the present embodiment can be with
With other thickness or density or replace with other materials.
Although the illustrative specific embodiment of the present invention is described above, in order to the technology of the art
Personnel understand the present invention, it should be apparent that the present invention is not limited to the range of specific embodiment, to the common skill of the art
For art personnel, if various change the attached claims limit and determine the spirit and scope of the present invention in, these
Variation is it will be apparent that all within the scope of protection of present invention.
Claims (10)
1. a kind of neutron capture treatment system, including accelerator, beam transport part and neutron beam generating unit, the accelerator is to band
Charged particle carries out accelerating to generate charged particle beam, and the Transport of Charged Particle Beams that the beam transport part generates the accelerator is extremely
The neutron beam generating unit, the neutron beam generating unit generate treatment neutron beam, which is characterized in that the neutron beam generating unit
Including the first neutron beam generating unit, the second neutron beam generating unit and third neutron beam generating unit, the beam transport part include with
First transport part of accelerator connection, the beam direction switch for switching charged particle beam direction of travel and respectively will electrification
The particle beams from the beam direction switch be transferred to the first, second, third neutron beam generating unit second, third and the
Four transport parts, described first, first plane of the third and fourth transport part two definition therein, first and second transport part
Define the second plane, first plane and the second plane difference.
2. neutron capture treatment system as described in claim 1, which is characterized in that first transport part passes along the x axis
Defeated, the third, the transmission direction of the 4th transport part are in X/Y plane and formation is greater than 0 degree of angle.
3. neutron capture treatment system as claimed in claim 2, which is characterized in that second transport part is passed along Z-direction
Defeated, the third, the transmission direction of the 4th transport part and the transmission direction of first transport part are Y-shaped.
4. neutron capture treatment system as described in claim 1, which is characterized in that the neutron capture treatment system further includes
Instrument table, the neutron beam generating unit include target, beam-shaping body and collimator, and the target setting is transmitted in the beam
Between portion and the beam-shaping body, the charged particle beam that the accelerator generates is irradiated to the target through the beam transport part
Material simultaneously acts on generation neutron with the target, and the neutron of the generation passes sequentially through the beam-shaping body and collimator formation is controlled
Treatment neutron beam simultaneously irradiates the patient on the instrument table.
5. neutron capture treatment system as claimed in claim 4, which is characterized in that the beam-shaping body include reflector,
Slow body, thermal neutron absorber, radiation shield and beam outlet, the neutron degradation that the slow body will be generated from the target
To epithermal neutron energy area, the reflector surrounds the slow body and the neutron that will deviate from is super to improve back to the slow body
Thermal neutron intensity of beam caused when the thermal neutron absorber is for absorbing thermal neutron to avoid treatment with shallow-layer normal tissue
Multi-dose, the radiation shield around the beam outlet be arranged in the reflector rear portion for shield leakage neutron with
For photon to reduce the normal tissue dose in non-irradiated area, the collimator, which is arranged, goes out metastomium in the beam to converge neutron
Radiation shield device is arranged to shield the beam for exporting out from the beam to patient in beam between the patient and beam outlet
The radiation of normal tissue, the beam transport part have the vacuum tube for being accelerated to charged particle beam or being transmitted, the vacuum
Pipe protrudes into the beam-shaping body along charged particle beam direction, and sequentially passes through the reflector and slow body, and the target is set
It sets described slow in vivo and positioned at the end of the vacuum tube.
6. neutron capture treatment system as described in claim 1, which is characterized in that first, second, third neutron beam is raw
At portion respectively along it is described second, third, the setting of the transmission direction of the 4th transport part, first, second, third neutron beam generates
Portion generate neutron beam direction respectively with it is described second, third, the transmission direction of the 4th transport part it is identical so that described second,
The neutron beam direction that third neutron beam generating unit generates in the same plane, the neutron beam that the first neutron beam generating unit generates
Direction is vertical with the plane.
7. neutron capture treatment system as described in claim 1, which is characterized in that the beam direction switch includes the
One, the second beam direction switch, the beam transport part further include the of connection the first, second beam direction switch
Five transport parts, second transport part connects the first beam direction switch and the first neutron beam generating unit, described
Third transport part connects the second beam direction switch and the second neutron beam generating unit, the 4th transport part connection
The second beam direction switch and the third neutron beam generating unit.
8. neutron capture treatment system as claimed in claim 7, which is characterized in that the first, second beam direction switching
Device includes the deflection electromagnet for deflecting charged particle beam direction and the switch electromagnet for controlling charged particle beam direction of travel, institute
Stating boron neutron capture treatment system further includes the beam trap for carrying out the output confirmation of charged particle beam before the treatment, institute
It states first or second beam direction switch and guides the beam trap, the described first, second, third, fourth, the 5th transmission into
Portion includes the beam adjustment section for charged particle beam, it is described second, third, the 4th transport part include current monitor and electrification
Particle beams scanner section.
9. neutron capture treatment system as claimed in claim 4, which is characterized in that the boron neutron capture treatment system is also wrapped
Exposure cell is included, the patient on the instrument table carries out the treatment of neutron beam irradiation in the exposure cell, and the exposure cell includes
The first, second, and third exposure cell corresponding with the first, second, third neutron beam generating unit, described first,
Two, third exposure cell respectively along it is described second, third, the setting of the transmission direction of the 4th transport part.
10. neutron capture treatment system as claimed in claim 9, which is characterized in that the boron neutron capture treatment system is also
Room is generated including charged particle beam, the charged particle beam generates room and accommodates the accelerator and at least partly described beam transmission
Portion and including accelerator room and beam transfer chamber, first transport part extends to the beam transmission from the accelerator room
Room, at least part of second, third neutron beam generating unit are embedded in second, third described exposure cell and beam transfer chamber
Partition wall, the third, the 4th transport part extend to second, third described neutron beam generating unit from the beam transfer chamber,
The first neutron beam generating unit is located in first exposure cell, and second transport part passes through ground from the beam transfer chamber
Plate extends to first exposure cell, and the boron neutron capture treatment system further includes preparation room and control room.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710799364.4A CN109464749B (en) | 2017-09-07 | 2017-09-07 | Neutron capture therapy system |
| EP21178910.2A EP3922307A1 (en) | 2017-09-07 | 2018-08-16 | Neutron capture therapy system |
| RU2020109210A RU2745081C1 (en) | 2017-09-07 | 2018-08-16 | Neutron capture therapy system |
| EP18852829.3A EP3666337B1 (en) | 2017-09-07 | 2018-08-16 | Neutron capture therapy system |
| PCT/CN2018/100753 WO2019047697A1 (en) | 2017-09-07 | 2018-08-16 | Neutron capture therapy system |
| JP2020513396A JP2020519420A (en) | 2017-09-07 | 2018-08-16 | Neutron capture therapy system |
| TW107129502A TWI686225B (en) | 2017-09-07 | 2018-08-23 | Neutron capture therapy system |
| US16/745,565 US11058898B2 (en) | 2017-09-07 | 2020-01-17 | Neutron capture therapy system |
| US17/243,998 US11583702B2 (en) | 2017-09-07 | 2021-04-29 | Neutron capture therapy system |
| JP2023057086A JP2023078466A (en) | 2017-09-07 | 2023-03-31 | Neutron capture therapy system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710799364.4A CN109464749B (en) | 2017-09-07 | 2017-09-07 | Neutron capture therapy system |
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| CN109464749A true CN109464749A (en) | 2019-03-15 |
| CN109464749B CN109464749B (en) | 2024-02-23 |
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| CN201710799364.4A Active CN109464749B (en) | 2017-09-07 | 2017-09-07 | Neutron capture therapy system |
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|---|---|---|---|---|
| CN108934120A (en) * | 2017-05-26 | 2018-12-04 | 南京中硼联康医疗科技有限公司 | Target and neutron capture treatment system for neutron beam generating apparatus |
| CN108934120B (en) * | 2017-05-26 | 2024-04-12 | 南京中硼联康医疗科技有限公司 | Target for neutron ray generating device and neutron capturing treatment system |
| WO2021129158A1 (en) * | 2019-12-24 | 2021-07-01 | 中硼(厦门)医疗器械有限公司 | Radiation irradiation system |
| JP2023504083A (en) * | 2019-12-24 | 2023-02-01 | 中硼（厦▲門▼）医▲療▼器械有限公司 | Radiation irradiation system |
| CN111420307A (en) * | 2020-04-16 | 2020-07-17 | 中国原子能科学研究院 | Neutron beam device and neutron irradiation device |
| CN113952636A (en) * | 2020-07-20 | 2022-01-21 | 中硼(厦门)医疗器械有限公司 | Radiotherapy system and safety interlocking control method thereof |
| CN113952635A (en) * | 2020-07-20 | 2022-01-21 | 中硼(厦门)医疗器械有限公司 | Radiotherapy system and safety interlocking control method thereof |
| CN113952636B (en) * | 2020-07-20 | 2023-08-08 | 中硼(厦门)医疗器械有限公司 | Radiation therapy system and safety interlocking control method thereof |
| WO2022170986A1 (en) * | 2021-02-09 | 2022-08-18 | 中硼(厦门)医疗器械有限公司 | Neutron-capture therapy system |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201912200A (en) | 2019-04-01 |
| TWI686225B (en) | 2020-03-01 |
| CN109464749B (en) | 2024-02-23 |
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Application publication date: 20190315 Assignee: China boron (Xiamen) medical equipment Co.,Ltd. Assignor: NEUBORON MEDTECH LTD. Contract record no.: X2019320000054 Denomination of invention: Radiant ray detection system and radiant ray detection method for neutron capture treatment system License type: Common License Record date: 20190910 |
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