TW201912200A - Neutron capture therapy system - Google Patents

Abstract

Provided is a neutron capture therapy system, wherein same can effectively use a space and perform therapy on a plurality of patients at the same time, and same does not excessively prolong the route of beam transmission and has a relatively small loss. The neutron capture therapy system in the present invention comprises an accelerator accelerating charged particles to generate charged particle beams, a beam transmission part transmitting the charged particle beams generated by the accelerator to a neutron beam generation part, and the neutron beam generation part generating neutron beams for performing therapy, wherein the neutron beam generation part comprises first, second and third neutron beam generation parts; the beam transmission part comprises a first transmission part connected to the accelerator, a beam direction switcher switching a direction of travel of the charged particle beams, and second, third and fourth transmission parts respectively transmitting the charged particle beams from the beam direction switcher to the first, second and third neutron beam generation parts; two of the first, third and fourth transmission parts define a first plane; the first and second transmission parts define a second plane; and the first plane is different from the second plane.

Description

   Neutron Capture Therapy System   

The invention relates to a radiation irradiation system, in particular to a neutron capture treatment system.

With the development of atomic science, radiation therapy such as cobalt sixty, linear accelerator, electron beam has become one of the main means of cancer treatment. However, traditional photon or electron therapy is limited by the physical conditions of the radiation itself. While killing tumor cells, it will also cause damage to a large number of normal tissues in the beam path. In addition, due to the different sensitivity of tumor cells to radiation, traditional radiation therapy Treatment of radiation-resistant malignancies (eg, glioblastoma multiforme, melanoma) is often not effective.

In order to reduce radiation damage to normal tissues surrounding tumors, the concept of target therapy in chemotherapy has been applied to radiation therapy. At the same time, tumor cells with high radiation resistance have also been actively developed with high relative biological effects. biological effectiveness (RBE) radiation sources, such as proton therapy, heavy particle therapy, neutron capture therapy, etc. Among them, neutron capture therapy is a combination of the above two concepts, such as boron neutron capture therapy, which uses boron-containing drugs to specifically accumulate in tumor cells and cooperates with precise neutron beam regulation to provide better than traditional radiation. Cancer treatment options.

Various radiations are generated during the radiation treatment process, such as low-to-high-energy neutrons and photons generated by the boron neutron capture treatment process. These radiations may cause different degrees of damage to the normal tissues of the human body. Therefore, in the field of radiation therapy, how to achieve effective treatment while reducing radiation pollution to the external environment, medical staff or normal tissues of patients is an extremely important subject. At the same time, in the current accelerator boron neutron capture therapy, multiple patients cannot be treated at the same time, or the layout of multiple irradiation chambers is unreasonable, the transmission path of the charged particle beam is long, and losses are generated.

Therefore, it is necessary to propose a new technical solution to solve the above problems.

In order to solve the above problems, an aspect of the present invention provides a neutron capture treatment system, which includes an accelerator, a beam transmission section, and a neutron beam generation section. The accelerator accelerates charged particles to generate a charged particle beam, and the beam transmission section generates the accelerator. The charged particle beam is transmitted to the neutron beam generation unit, which generates a therapeutic neutron beam. The neutron beam generation unit includes a first neutron beam generation unit, a second neutron beam generation unit, and a third neutron. A beam generating unit and a beam transmitting unit including a first transmitting unit connected to an accelerator, a beam direction switcher for switching a traveling direction of a charged particle beam, and transmitting a charged particle beam from the beam direction switcher to the first, second, and The second, third, and fourth transmission sections of the third neutron beam generating section, two of the first, third, and fourth transmission sections define a first plane, and the first and second transmission sections define a second plane, The first and second planes are different. With this arrangement, space can be effectively used and multiple patients can be treated at the same time. There is no excessively long beam transmission line, and the loss is small.

The first transmission section transmits in the X-axis direction, and the transmission directions of the third and fourth transmission sections are in the XY plane and form an included angle greater than 0 degrees. Furthermore, the second transmission section transmits along the Z-axis direction, and the transmission directions of the third and fourth transmission sections are in a "Y" shape with the transmission direction of the first transmission section.

The neutron capture treatment system further includes a treatment table. The neutron beam generating section includes a target, a beam shaper, and a collimator. The target is disposed between the beam transmission section and the beam shaper. The charged particle beam generated by the accelerator The beam is irradiated to the target through the beam transmission part and interacts with the target to generate neutrons. The generated neutrons pass through the beam shaper and the collimator to form a neutron beam for treatment and irradiate the patient on the treatment table.

The beam shaping body includes a reflector, a retarder, a thermal neutron absorber, a radiation shield, and a beam exit. The retarder reduces the neutrons generated from the target to the superheated neutron energy region, and the reflector surrounds the retarder. The deviated neutrons are guided back to the retarder to increase the intensity of the superheated neutron beam. The thermal neutron absorber is used to absorb thermal neutrons to avoid excessive doses with shallow normal tissue during treatment. The radiation shield surrounds the beam exit. The neutron and photon are arranged at the back of the reflector to reduce the leakage of normal tissue in the non-irradiated area. The collimator is set at the back of the beam exit to focus the neutron beam. A radiation shield is set between the patient and the beam exit The device shields the patient's normal tissue from the beam exiting the beam exit. The beam transmission part has a vacuum tube for accelerating or transmitting the charged particle beam, which extends the incident beam shaping body in the direction of the charged particle beam, and passes through the reflector and the retarder in sequence. The target is set in the retarder and located in the vacuum tube. Ends.

The boron neutron capture treatment system further includes an irradiation room, and a patient on the treatment table performs a treatment of neutron beam irradiation in the irradiation room, and the irradiation room includes first, second, and third neutron beam generating sections respectively corresponding to the first , Second, and third irradiation chambers, and the first, second, and third irradiation chambers are respectively disposed along the transmission directions of the second, third, and fourth transmission sections.

The boron neutron capture therapy system further includes a charged particle beam generating chamber that houses an accelerator and at least a portion of a beam transmitting portion. The charged particle beam generation chamber includes an accelerator chamber and a beam transmission chamber. The first transmission section extends from the accelerator chamber to the beam transmission chamber, and at least a part of the second and third neutron beam generation sections are buried in the second and third irradiations. The third and fourth transmission sections extend from the beam transmission chamber to the second and third neutron beam generating sections. The first neutron beam generating section is located in the first irradiation chamber and the second The transmission section extends from the beam transmission room through the floor to the first irradiation room. The boron neutron capture treatment system further includes a preparation room and a control room.

The first, second, and third neutron beam generating sections are respectively disposed along the transmission directions of the second, third, and fourth transmitting sections, and the neutron beam directions generated by the first, second, and third neutron beam generating sections are respectively The transmission direction is the same as that of the second, third, and fourth transmission sections, so that the directions of the neutron beams generated by the second and third neutron beam generating sections are in the same plane, and the neutron beams generated by the first neutron beam generating section The direction is perpendicular to the plane.

The beam direction switch includes first and second beam direction switches. The beam transmission section further includes a fifth transmission section connected to the first and second beam direction switches. The second transmission section is connected to the first beam direction. The switcher and the first neutron beam generation unit, the third transmission unit is connected to the second beam direction switcher and the second neutron beam generation unit, and the fourth transmission unit is connected to the second beam direction switcher and the third neutron beam Generation department.

The first and second beam direction switchers include a deflection electromagnet that deflects the direction of the charged particle beam and a switch electromagnet that controls the direction of travel of the charged particle beam. The boron neutron capture treatment system further includes a charged particle beam before treatment. The output of the beam collector is confirmed, the first or second beam direction switcher is directed to the beam collector, and the first, second, third, fourth, and fifth transmission sections include a beam for charged particle beams. The beam adjustment section, the second, third, and fourth transmission sections include a current monitor and a charged particle beam scanning section.

The neutron capture treatment system of the present invention can effectively use space and treat multiple patients simultaneously, without excessively extending the beam transmission line, and the loss is small.

100‧‧‧ Boron Neutron Capture and Treatment System

10‧‧‧ accelerator

20‧‧‧ Beam Transmission Department

21‧‧‧First Transmission Department

22, 23‧‧‧ First and second beam direction switchers

24‧‧‧Second Transmission Department

25A, 25B, 25C‧‧‧th third, fourth and fifth transmission department

26‧‧‧shield

30 (30A, 30B, 30C) ‧‧‧ Neutron Beam Generation Department

31‧‧‧ Beam Shaping Body

311‧‧‧Reflector

312‧‧‧ Slow body

313‧‧‧ thermal neutron absorber

314‧‧‧radiation shield

315‧‧‧ Beam Exit

32‧‧‧ Collimator

40‧‧‧Treatment Table

50‧‧‧ radiation shielding device

60, 70, 80‧‧‧ first, second, third shield

101 (101A, 101B, 101C) ‧‧‧ Irradiation Room

102‧‧‧Charged particle beam generation chamber

1021‧‧‧Accelerator Room

1022‧‧‧ Beam Transmission Room

200‧‧‧patients

T‧‧‧Target

P‧‧‧Charged particle beam

N‧‧‧ Neutron Beam

M‧‧‧ tumor cells

C‧‧‧vacuum tube

L1, L2‧‧‧ floors

S‧‧‧Floor

W1‧‧‧shield wall

W2, W3, W4‧‧‧‧ First, second, and third partition shield walls

W5‧‧‧Inner shield wall

D1, D2, D3, D4, D5, D6, D7‧‧‧ Shielded doors

D‧‧‧Main shield door

D’ ‧‧‧ times shielded door

FIG. 1 is a schematic structural diagram of a boron neutron capture treatment system in an embodiment of the present invention.

FIG. 2 is a schematic layout diagram of a neutron capture therapy system in an XY plane according to an embodiment of the present invention.

Fig. 3 is a schematic view taken along the line A-A in Fig. 2.

The embodiments of the present invention are further described in detail below with reference to the accompanying drawings, so that those skilled in the art can implement the present invention with reference to the description text. An XYZ coordinate system is set in which the direction of the charged particle beam P emitted by the accelerator described later is the X axis, the direction orthogonal to the direction of the charged particle beam P emitted by the accelerator is the Y axis, and the direction perpendicular to the ground is the Z axis. (Refer to FIG. 2 and FIG. 3), and X, Y, and Z are used in the description of the positional relationship of each constituent element.

As shown in FIG. 1, the neutron capture therapy system in this embodiment is preferably a boron neutron capture therapy system 100. The boron neutron capture therapy system 100 is a device for cancer treatment using boron neutron capture therapy. Boron neutron capture therapy treats cancer by irradiating neutron beam N to patient 200 who has been injected with boron (B-10) drug. After patient 200 takes or injects boron (B-10) drug, boron-containing drug selectively Gathered in tumor cells M, and then use boron-containing (B-10) drugs to have high capture cross-section characteristics for thermal neutrons, and ⁴ He and ⁷ Li are generated by ¹⁰ B (n, α) ⁷ Li neutron capture and mitotic reactions Two heavily charged particles. The average energy of two charged particles is about 2.33 MeV, which has high linear energy transfer (LET) and short range characteristics. The linear energy transfer and range of α short particles are 150 keV / μm and 8 μm, respectively, and ⁷ Li heavy-loaded particles It is 175keV / μm, 5μm. The total range of the two particles is about the size of a cell. Therefore, the radiation damage caused to the organism can be limited to the cell level, and it can be achieved locally without causing too much damage to normal tissues. The purpose of killing tumor cells.

The boron neutron capture treatment system 100 includes an accelerator 10, a beam transmitting section 20, a neutron beam generating section 30, and a treatment table 40. The accelerator 10 accelerates the charged particles (such as protons, deuterons, etc.) to generate a charged particle beam P such as a proton beam; the beam transmission unit 20 transmits the charged particle beam P generated by the accelerator 10 to the neutron beam generating unit 30; The neutron beam generating unit 30 generates a neutron beam N for treatment and irradiates the patient 200 on the treatment table 40.

The neutron beam generating section 30 includes a target T, a beam shaping body 31, and a collimator 32. The charged particle beam P generated by the accelerator 10 is irradiated to the target T through the beam transmitting section 20 and interacts with the target T to generate neutrons. The generated neutrons pass through the beam shaper 31 and the collimator 32 to form a neutron beam N for treatment and irradiate the patient 200 on the treatment table 40. The target T is preferably a metal target. Select the appropriate nuclear reaction based on the required neutron yield and energy, the energy and current available for the accelerated charged particles, and the physical and chemical properties of the metal target. The nuclear reactions that are often discussed are ⁷ Li (p, n) ⁷ Be and ⁹ Be (p, n) ⁹ B. Both of these reactions are endothermic reactions. The energy thresholds of the two nuclear reactions are 1.881 MeV and 2.055 MeV, respectively. Since the ideal neutron source for boron neutron capture therapy is super thermal neutrons of keV energy level, theoretically, if a proton with an energy slightly higher than the threshold is used to bombard a lithium metal target Materials, which can generate relatively low-energy neutrons, can be used in the clinic without too much slow-speed treatment. However, the lithium metal (Li) and beryllium metal (Be) targets and threshold energy proton interaction cross sections are not high. To generate a sufficiently large neutron flux, higher energy protons are usually used to initiate the nuclear reaction. The ideal target should have high neutron yield, neutron energy distribution close to the superthermal neutron energy region (described in detail below), no too much strong penetrating radiation, safe and cheap, easy to operate, and high temperature resistance. It is not actually possible to find a nuclear reaction that meets all requirements. As is well known to those skilled in the art, the target T may also be made of a metal material other than Li and Be, for example, Ta or W and an alloy thereof. The accelerator 10 may be a linear accelerator, a cyclotron, a synchrotron, or a synchrocyclotron.

The beam shaper 31 can adjust the beam quality of the neutron beam N generated by the action of the charged particle beam P and the target T, and the collimator 32 is used to converge the neutron beam N so that the neutron beam N is in the process of treatment. Has higher targeting. The beam shaper 31 further includes a reflector 311, a retarder 312, a thermal neutron absorber 313, a radiation shield 314, and a beam exit 315. The neutrons generated by the interaction of the charged particle beam P with the target T have a wide energy spectrum. In addition to superheated neutrons to meet the needs of treatment, other types of neutrons and photons need to be reduced as much as possible to avoid harm to the operator or the patient. Therefore, the neutrons coming out of the target T need to be passed through the retarder 312. The fast neutron energy (> 40keV) is adjusted to the superthermal neutron energy range (0.5eV-40keV) and the thermal neutron is reduced as much as possible (<0.5eV). Made of a material with a small active cross section. In this embodiment, the retarder 312 is made of at least one of D ₂ O, AlF ₃ , Fluental, CaF ₂ , Li ₂ CO ₃ , MgF ₂ and Al ₂ O ₃ ; The body 311 surrounds the retarding body 312, and reflects the neutrons diffused through the retarding body 312 back to the neutron beam N to improve the neutron utilization rate. The body 311 is made of a material with strong neutron reflection ability. In the embodiment, the reflector 311 is made of at least one of Pb or Ni; Each thermal neutron absorber 313 is made of a material having a large cross section with thermal neutrons. In this embodiment, the thermal neutron absorber 313 is made of Li-6, and the thermal neutron absorber 313 is used to absorb through the retarder 312. Thermal neutrons to reduce the content of thermal neutrons in the neutron beam N, to avoid excessive doses with shallow normal tissues during treatment; a radiation shield 314 is provided around the beam exit 315 at the rear of the reflector to shield the beam exit 315 For neutrons and photons leaking from other parts, the material of the radiation shielding body 314 includes at least one of a photon shielding material and a neutron shielding material. In this embodiment, the material of the radiation shielding body 314 includes photon shielding material lead (Pb) and Neutron shielding material polyethylene (PE). It can be understood that the beam shaping body 31 may have other structures as long as it can obtain the superheated neutron beam required for treatment. The collimator 32 is arranged at the rear of the beam exit 315. The superheated neutron beam from the collimator 32 is irradiated to the patient 200. After passing through the shallow normal tissue, it is slowed down to reach the tumor cell M by thermal neutrons. The device 32 can also be eliminated or replaced by other structures. The neutron beam exits the beam exit 315 and directly irradiates the patient 200. In this embodiment, a radiation shielding device 50 is further provided between the patient 200 and the beam exit 315 to shield the radiation from the beam exiting the beam exit 315 to the normal tissue of the patient. It is understood that the radiation shielding device 50 may not be provided. . The target T is disposed between the beam transmitting section 20 and the beam shaping body 31. The beam transmitting section 20 has a vacuum tube C for accelerating or transmitting the charged particle beam P. In this embodiment, the vacuum tube C follows the charged particle beam P The incident beam shaping body 31 extends in the direction and passes through the reflector 311 and the retarder 312 in this order. The target T is disposed in the retarder 312 and located at the end of the vacuum tube C to obtain better neutron beam quality. It can be understood that the target material can be provided in other ways, and can also be movable relative to the accelerator or the beam shaper to facilitate the target change or make the charged particle beam interact with the target material uniformly.

With reference to FIGS. 2 and 3, the boron neutron capture therapy system 100 is configured in the space of two floors L1 and L2 as a whole. The boron neutron capture therapy system 100 further includes an irradiation chamber 101 (101A, 101B, 101C) and charged particle beam generation. In the chamber 102, the patient 200 on the treatment table 40 performs the treatment of neutron beam N irradiation in the irradiation chamber 101 (101A, 101B, 101C). The charged particle beam generating chamber 102 houses the accelerator 10 and at least a part of the beam transmission unit 20. The neutron beam generating section 30 may have one or more to generate one or more therapeutic neutron beams N, and the beam transmitting section 20 may selectively transmit the charged particle beam P to one or several neutron beam generating sections 30. Or, the charged particle beam P is transmitted to a plurality of neutron beam generating sections 30 at the same time, and each neutron beam generating section 30 corresponds to one irradiation chamber 101. In this embodiment, there are three neutron beam generating sections and irradiation chambers, which are neutron beam generating sections 30A, 30B, and 30C and irradiation chambers 101A, 101B, and 101C, respectively. The beam transmission unit 20 includes a first transmission unit 21 connected to the accelerator 10, first and second beam direction switches 22 and 23 to switch the traveling direction of the charged particle beam P, and a second transmission unit 24 connected to the first And second beam direction switchers 22 and 23; the third, fourth, and fifth transmission sections 25A, 25B, and 25C respectively switch the charged particle beam P from the first beam direction switcher 22 or the second beam direction The device 23 is transmitted to the neutron beam generating sections 30A, 30B, and 30C, and the generated neutron beam N is irradiated to patients in the irradiation chambers 101A, 101B, and 101C, respectively. The third transmission section 25A is connected to the first beam direction switcher 22 and the neutron beam generation section 30A, the fourth transmission section 25B is connected to the second beam direction switcher 23 and the neutron beam generation section 30B, and the fifth transmission section 25C is connected The second beam direction switcher 23 and the neutron beam generating section 30C. That is, the first transmission section 21 is branched into the second transmission section 24 and the third transmission section 25A in the first beam direction switch 22, and the second transmission section 24 is branched into the first transmission section 23 in the second beam direction switch 23. Four transmission sections 25B and fifth transmission section 25C. The first and second transmission sections 21 and 24 are transmitted in the X-axis direction, the third transmission section 25A is transmitted in the Z-axis direction, and the fourth and fifth transmission sections 25B and 25C are in the XY plane and the first and first transmission sections are in the XY plane. The transmission directions of the two transmission sections 21 and 24 are "Y", and the neutron beam generating sections 30A, 30B, and 30C and the corresponding irradiation chambers 101A, 101B, and 101C respectively follow the third, fourth, and fifth transmission sections 25A, 25B. And 25C transmission directions are set, and the neutron beam N directions generated are the same as the transmission directions of the third, fourth, and fifth transmission sections 25A, 25B, and 25C, respectively, so that the neutron beam generated by the neutron beam generation sections 30B and 30C The directions are in the same plane, and the neutron beam direction generated by the neutron beam generating section 30A is perpendicular to the plane. With this arrangement, space can be effectively used and multiple patients can be treated at the same time. There is no excessively long beam transmission line, and the loss is small. It can be understood that the transmission direction of the neutron beam N generated by the neutron beam generating section 30A (30B, 30C) and the third (fourth, fifth) transmission section 25A (25B, 25C) may be different; The transmission directions of the second transmission sections 21 and 24 can also be different. The second transmission section 24 can also be canceled. It has only one beam direction switcher and branches the beam into two or more transmission sections; the fourth and fifth The “Y” shape formed by the transmission directions of the transmission sections 25B and 25C and the transmission direction of the first transmission section 21 may also be a deformation of “Y”. For example, the transmission direction of the fourth transmission section 25B or the fifth transmission section 25C is the same as that of the first transmission section 25C. The transmission direction of one transmission section 21 is the same. The transmission directions of the fourth and fifth transmission sections 25B and 25C and the transmission direction of the first transmission section 21 may also be in other shapes, such as a "T" shape or an arrow shape. The transmission directions of the fifth transmission sections 25B and 25C may be formed at an angle greater than 0 degrees in the XY plane; the transmission directions of the fourth and fifth transmission sections 25B and 25C are not limited to the XY plane, and the transmission direction of the third transmission section 25A is also It may not be along the Z axis, as long as the transmission direction of the fourth transmission section 25B, the fifth transmission Two of the transmission direction of the transmission section 25C and the transmission direction of the first transmission section 21 are in the same plane (first plane), and the transmission direction of the first transmission section 21 and the transmission direction of the third transmission section 25A are also on the same plane. (The second plane), and the first and second planes are different; the third transmission section 25A, the neutron beam generating section 30A, and the irradiation chamber 101A can also be eliminated, so that only beam transmission in the XY plane is possible.

The first and second beam direction switches 22 and 23 include a deflection electromagnet that deflects the charged particle beam P direction and a switch electromagnet that controls the traveling direction of the charged particle beam P. The boron neutron capture treatment system 100 may further include a beam Collector (not shown) to check the output of the charged particle beam P before treatment, etc. The first or second beam direction switchers 22 and 23 can move the charged particle beam P out of the normal orbit and lead to the beam collector. .

The first transmission section 21, the second transmission section 24, and the third, fourth, and fifth transmission sections 25A, 25B, and 25C are each constructed of a vacuum tube C, and may be formed by connecting a plurality of sub-transmission sections, and the transmission directions of the plurality of sub-transmission sections. It can be the same or different, such as the deflection of the beam transmission direction by the deflection electromagnet, the transmission directions of the first, second, third, fourth, and fifth transmission sections 21, 24, 25A, 25B, 25C It can be the transmission direction of any of its sub-transmission sections. The first and second planes formed above are the planes formed between the sub-transmission sections that are directly connected to the beam direction switcher. They can also include a charged particle beam. A beam adjustment section (not shown) of P, the beam adjustment section includes a level steering device and a level vertical steering device for adjusting the axis of the charged particle beam P, and a quadrupole electromagnetic for suppressing the divergence of the charged particle beam P. Iron, and a four-way cutter for shaping the charged particle beam P, and the like. The third, fourth, and fifth transmission sections 25A, 25B, and 25C may include a current monitor (not shown) and a charged particle beam scanning section (not shown) as needed. The current monitor immediately measures the current value (that is, the charge and irradiation dose rate) of the charged particle beam P irradiated to the target T. The charged particle beam scanning section scans the charged particle beam P to perform irradiation control of the charged particle beam P with respect to the target T, such as controlling the irradiation position of the charged particle beam P with respect to the target T.

The charged particle beam generation chamber 102 may include an accelerator chamber 1021 and a beam transmission chamber 1022. The accelerator chamber 1021 is two-layered, and the accelerator 10 extends from L2 to L1. The beam transmission chamber 1022 is located at L2, and the first transmission portion 21 extends from the accelerator chamber 1021 to the beam transmission chamber 1022. The irradiation chambers 101B and 101C are located at L2, and the irradiation chamber 101A is located at L1. In this embodiment, L1 is below L2, that is, the floor of L2 is the ceiling of L1. It can be understood that the configuration can also be reversed. The material of the floor (ceiling) S may be concrete having a thickness of 0.5 m or more or boron-containing barite concrete. The irradiation chambers 101A, 101B, 101C and the beam transmission chamber 1022 are provided with a shielded space surrounded by a shielded wall W1. The shielded wall W1 may be a boron-containing barite concrete wall with a thickness of 1 m or more and a density of 3 g / cc. The beam partitioning chamber 1022 is separated from the irradiation chambers 101B and 101C by a first partition shield wall W2, and the second partition shield wall W3 of the accelerator chamber 1021 and the beam transfer chamber 1022 is partitioned by L1. Third partition shield wall W4. The accelerator chamber 1021 is surrounded by a concrete wall W having a thickness of 1 m or more, a second partition shield wall W3, and a third partition shield wall W4. At least a part of the neutron beam generating sections 30B and 30C is buried in the first partition shield wall W2, and the fourth and fifth transmitting sections 25B and 25C extend from the beam transmitting chamber 1022 to the neutron beam generating sections 30B and 30C; The beam generating section 30A is located in the irradiation room 101A, and the third transmission section 25A extends from the beam transmission room 1022 through the floor S to the irradiation room 101A. The irradiation rooms 101A, 101B, and 101C respectively have shielded doors D1, D2, and D3 for the treatment table 40 and the physician. The accelerator room 1021 has shielded doors D4 and D5 for the accelerator 10 in and out of the accelerator room 1021 at L1 and L2, respectively. The beam transmission chamber 1022 includes a shield door D6 for maintaining the beam transmission unit 20 from the accelerator chamber 1021 to the beam transmission chamber 1022. The shield door D6 is provided on the second partition shield wall W3. The interior of the irradiation rooms 101A, 101B, and 101C also has an inner shield wall W5 to form a labyrinth passage from the shield doors D1, D2, and D3 to the beam exit to prevent direct radiation when the shield doors D1, D2, and D3 are accidentally opened. According to the different layout of the irradiation room, the shielding wall W5 can be set at different positions, and a shielding door D7 inside the irradiation room can be provided between the internal shielding wall W5 and the shielding wall W1 or the third partition shielding wall W4. Secondary protection during neutron beam irradiation treatment. The inner shielding wall W5 can be a boron-containing barite concrete wall with a thickness of 0.5m or more and a density of 3g / cc; the shielding doors D1, D2, D3, D4, D5, D6, D7 can be composed of two independent main shielding doors. D and the secondary shielding door D 'or only the primary shielding door D or the secondary shielding door D' can be determined according to the actual situation. The primary shielding door D can be made of the same material with a thickness of 0.5m or more and a density of 6g / cc. Boron-containing PE or barite concrete or lead, and the secondary shielding door D ′ may be boron-containing PE or barite concrete or lead of the same material having a thickness of 0.2 m or more and a density of 6 g / cc. In this embodiment, the shielding doors D1, D4, D5, and D6 are composed of the primary shielding door D and the secondary shielding door D '. The shielding doors D1, D2, and D3 include only the primary shielding door D, and the shielding door D7 includes only the secondary shielding door D. '. The shielding wall and the shielding door form a shielding space, and suppress the intrusion of radiation from the outside of the irradiation rooms 101A, 101B, 101C and the beam transmission room 1022 into the room, and radiation from the room to the outside. In this embodiment, a second partition shield wall W3 partitioning the accelerator chamber 1021 and the beam transmission chamber 1022 is provided between the accelerator 10 and the first beam direction switcher 22, that is, the first transmission portion 21 passes through the second partition Shielding wall W3. It can be understood that the second partitioning shielding wall W3 and the shielding door D6 can be cancelled, or can be set at other positions, such as between the first and second beam direction switches 22 and 23 or the second beam direction switch. Between the generator 23 and the neutron beam generating sections 30B and 30C; or an additional partition shield wall and a shield door are provided between the second partition shield wall W3 and the first partition shield wall W2. In other words, a shielding wall is provided between the neutron beam generating section and the accelerator, and the operator is protected from neutrons and other radiation leaking from the neutron beam generating section during the inspection and maintenance of the accelerator, and at the same time, the accelerator is reduced by neutrons. Activated response.

Leakage of neutrons and other radiation is likely to occur where the shielding wall or floor is penetrated by elements or components. As in this embodiment, the neutron beam generating sections 30B and 30C pass through the first partitioning shield wall W2 and the first transmission. The portion 21 passes through the second partition shield wall W3 and the third transmission portion 25A passes through the floor S. Neutrons are provided on the side of the first partition shield wall W2, the second partition shield wall W3, and the floor S facing the beam transmission direction. The first shielding body 60, the second shielding body 70, and the third shielding body 80 may be respectively provided at the positions where the beam generating sections 30B, 30C, the first transmitting section 21, and the third transmitting section 25A pass through. The first shielding body 60 covers the ends of the neutron beam generating sections 30B and 30C toward the accelerator and contacts the first partitioning shield wall W2 around the neutron beam generating sections 30B and 30C to prevent radiation from the neutron beam generating sections 30B and 30C. The neutrons overflowed or reflected by the beam shaper enter the accelerator chamber 1021 and the beam transmission chamber 1022, and the fourth and fifth transmission sections 25B and 25C pass through the first shield 60 and reach the target T of the neutron beam generation sections 30B and 30C. . The second shielding body 70 is in contact with the second partitioning shielding wall W3 around the first transmitting portion 21 to prevent neutrons overflowing or reflecting from the beam transmitting portion 20 from entering the accelerator chamber 1021, and the first transmitting portion 21 passes through the second shielding body 70 and the second partition shield wall W3 reach the first beam direction switcher 22. The third shielding body 80 is in contact with the floor S around the third transmission portion 25A to prevent neutrons overflowing or reflecting from the irradiation chamber 101A from entering the beam transmission room 1022, and the third transmission portion 25A passes through the third shielding body 80 and the floor S Reached the neutron beam generating section 30A. The materials of the first shield body 60, the second shield body 70, and the third shield body 80 may be boron-containing PE or barite concrete or lead.

The first and second beam direction switches 22 and 23 are respectively surrounded by a shield cover 26 to prevent leakage of neutrons and other radiation from the beam direction switch. The material of the shield cover 26 may be boron-containing PE or barite Concrete or lead. It can be understood that the first and second beam direction switches 22 and 23 can also be surrounded by a shielding cover 26 as a whole; other parts of the beam transmission part, such as a vacuum tube, can also be surrounded by a shielding cover to prevent neutrons and other radiation. The wire leaked from the beam transmitting part.

The boron neutron capture treatment system 100 may further include a preparation room, a control room and other spaces for auxiliary treatment, and each irradiation room may be provided with a preparation room for fixing a patient to a treatment table, injecting boron medicine, Preparations such as treatment plan simulation. A connection channel is set between the preparation room and the irradiation room. After the preparation is completed, the patient is directly pushed into the irradiation room or controlled by the control mechanism to automatically enter the irradiation room through the track. The preparation room and the connection channel are also The shielding wall is closed, and the preparation room also has a shielding door. The control room is used to control the accelerator, beam transmission department, treatment table, etc., to control and manage the entire irradiation process. The management staff can also monitor multiple irradiation rooms at the same time in the control room.

It can be understood that the shielding wall (including the concrete wall W), the shielding door, the shielding body, and the shielding cover in this embodiment may have other thicknesses or densities or be replaced with other materials.

Although the illustrative specific embodiments of the present invention have been described above so that those skilled in the art can understand the present invention, it should be clear that the present invention is not limited to the scope of the specific embodiments, and for those of ordinary skill in the art, As long as various changes are within the spirit and scope of the present invention as defined and determined by the appended claims, these changes are obvious and all fall within the scope of protection of the present invention.

Claims (10)

    A neutron capture therapy system includes an accelerator, a beam transmission unit, and a neutron beam generation unit. The accelerator accelerates charged particles to generate a charged particle beam, and the beam transmission unit transmits the charged particle beam generated by the accelerator to a neutron beam. A generating unit that generates a neutron beam for therapy, the neutron beam generating unit including a first neutron beam generating unit, a second neutron beam generating unit, and a third neutron beam generating unit; The transmission section includes a first transmission section connected to the accelerator, a beam direction switcher that switches the traveling direction of the charged particle beam, and transmits the charged particle beam from the beam direction switcher to the first, second, and third, respectively. The second, third, and fourth transmission sections of the beamlet generation section, two of the first, third, and fourth transmission sections define a first plane, the first and second transmission sections define a second plane, and The first and second planes are different.         The neutron capture treatment system according to item 1 of the scope of patent application, wherein the first transmission part is transmitted in the X-axis direction, and the transmission directions of the third and fourth transmission parts are in the XY plane and form a greater than 0 degree Angle.         The neutron capture therapy system according to item 2 of the scope of the patent application, wherein the second transmission part is transmitted along the Z-axis direction, and the transmission directions of the third and fourth transmission parts are the same as those of the first transmission part. "Y" type.         The neutron capture treatment system according to item 1 of the patent application scope, further comprising a treatment table, the neutron beam generating section includes a target, a beam shaper, and a collimator, and the target is provided in the beam transmitting section Between the beam shaper and the beam shaper, the charged particle beam generated by the accelerator is irradiated to the target through the beam transmission part and interacts with the target to generate neutrons. The generated neutrons are formed by the beam shaper and the collimator in order. The treatment uses a neutron beam and irradiates a patient on the treatment table.         The neutron capture treatment system described in item 4 of the patent application scope, wherein the beam shaper includes a reflector, a retarder, a thermal neutron absorber, a radiation shield, and a beam exit, and the retarder will The neutron generated by the target is decelerated to the superthermal neutron energy region, the reflector surrounds the retarder and directs the deviated neutrons back to the retarder to increase the intensity of the superthermal neutron beam. The thermal neutron absorber is used for Absorbing thermal neutrons to avoid excessive doses with shallow normal tissues during treatment. The radiation shield is arranged around the beam exit at the rear of the reflector to shield leaked neutrons and photons to reduce the normal tissue dose in non-irradiated areas. A collimator is arranged at the rear of the beam exit to converge the neutron beam. A radiation shielding device is provided between the patient and the beam exit to shield the radiation emitted from the beam exit to the normal tissue of the patient. The beam transmission section has A vacuum tube for accelerating or transmitting a charged particle beam extends into the beam shaping body in the direction of the charged particle beam and passes through the reflector and the retarder in sequence. The target is disposed in the retarder and located in the vacuum tube. Section.         The neutron capture treatment system according to item 1 of the scope of the patent application, wherein the first, second, and third neutron beam generating sections are disposed along the transmission directions of the second, third, and fourth transmission sections, respectively. The directions of the neutron beams generated by the first, second, and third neutron beam generating sections are the same as the transmission directions of the second, third, and fourth transmitting sections, respectively, so that the neutrons generated by the second and third neutron beam generating sections are the same. The beam directions are in the same plane, and the beam direction generated by the first neutron beam generating section is perpendicular to the plane.         According to the neutron capture treatment system described in the first item of the patent application scope, the beam direction switcher further includes first and second beam direction switchers, and the beam transmission section further includes a connection between the first and second beams. A fifth transmission section of the direction switch, the second transmission section is connected to the first beam direction switch and the first neutron beam generating section, and the third transmission section is connected to the second beam direction switch and the second neutron beam A generating unit, and the fourth transmitting unit is connected to the second beam direction switcher and the third neutron beam generating unit.         The neutron capture treatment system according to item 7 in the scope of the patent application, wherein the first and second beam direction switches include a deflection electromagnet that deflects the direction of the charged particle beam and a switch electromagnetic that controls the direction of travel of the charged particle beam. Iron, the boron neutron capture treatment system further includes a beam collector for confirming the output of the charged particle beam before the treatment, the first or second beam direction switcher is directed to the beam collector, the first The second, third, fourth, and fifth transmission sections include a beam adjustment section for a charged particle beam, and the second, third, and fourth transmission sections include a current monitor and a charged particle beam scanning section.         The neutron capture treatment system according to item 4 of the scope of patent application, further comprising an irradiation room, and the patient on the treatment table performs the treatment of neutron beam irradiation in the irradiation room. The first, second, and third irradiation chambers corresponding to the third and third neutron beam generating sections are respectively disposed along the transmission directions of the second, third, and fourth transmission sections.         The neutron capture therapy system according to item 9 of the scope of patent application, further comprising a charged particle beam generating chamber that houses an accelerator and at least a part of a beam transmission section and includes an accelerator chamber and a beam transmission chamber, the first transmission section Extending from the accelerator chamber to the beam transmission chamber, at least a part of the second and third neutron beam generating sections are buried in the partition walls of the second and third irradiation chambers and the beam transmission chamber, and the third and fourth transmissions The portion extends from the beam transmission chamber to the second and third neutron beam generating portions. The first neutron beam generating portion is located in the first irradiation chamber, and the second transmission portion extends from the beam transmission chamber through the floor to the first. The irradiation room, the boron neutron capture treatment system further includes a preparation room and a control room.