CN109464615A - A kind of anti-inflammatory heat-clearing cold granules and preparation method thereof - Google Patents
A kind of anti-inflammatory heat-clearing cold granules and preparation method thereof Download PDFInfo
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- CN109464615A CN109464615A CN201910020469.4A CN201910020469A CN109464615A CN 109464615 A CN109464615 A CN 109464615A CN 201910020469 A CN201910020469 A CN 201910020469A CN 109464615 A CN109464615 A CN 109464615A
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- dayflower
- cordate houttuynia
- rush
- asiatic plantain
- heat
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- 230000003110 anti-inflammatory effect Effects 0.000 title claims abstract description 25
- 239000008187 granular material Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 241000233838 Commelina Species 0.000 claims abstract description 26
- 235000013717 Houttuynia Nutrition 0.000 claims abstract description 26
- 241001499733 Plantago asiatica Species 0.000 claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 241000722870 Dicliptera chinensis Species 0.000 claims abstract description 25
- 235000021282 Sterculia Nutrition 0.000 claims abstract description 21
- 229940059107 sterculia Drugs 0.000 claims abstract description 21
- 244000185386 Thladiantha grosvenorii Species 0.000 claims abstract description 20
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 17
- 230000008569 process Effects 0.000 claims abstract description 15
- 235000020985 whole grains Nutrition 0.000 claims abstract description 15
- 238000001035 drying Methods 0.000 claims abstract description 10
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- 238000004806 packaging method and process Methods 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 5
- 239000006071 cream Substances 0.000 claims abstract description 4
- 240000000691 Houttuynia cordata Species 0.000 claims abstract 7
- 241000934878 Sterculia Species 0.000 claims description 20
- 239000002994 raw material Substances 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 11
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- 150000003839 salts Chemical class 0.000 claims description 3
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- 241001598107 Imperata Species 0.000 claims 2
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- 206010011224 Cough Diseases 0.000 abstract description 5
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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Abstract
The invention discloses a kind of anti-inflammatory heat-clearing cold granules and preparation method thereof, in parts by weight, dayflower 15 ~ 30, Dicliptera chinensis 25 ~ 40, Asiatic plantain 10 ~ 15, cordate houttuynia 15 ~ 20, the sterculia seed 8 ~ 16, Siraitia grosvenorii 15 ~ 22, Radix Glycyrrhizae 6 ~ 15, rush 7 ~ 12, rhizoma imperatae 12 ~ 20 are cleaned and drained, it is decocted for several times by mixing and water adding, filtering obtains filtered fluid, the processes such as last concentrated receipts cream, whole grain, drying, packaging, obtain finished product.The present invention can be used for alleviating in daily life because food hot gas is got angry, smoking throat inflammation leads to cigarette phlegm, excessive internal heat heat cough, can enhance the immune function of body, play the role of preventing cold.
Description
Technical field
The present invention relates to pharmaceutical technology field, espespecially a kind of anti-inflammatory heat-clearing cold granules and preparation method thereof.
Background technique
With the acceleration of people's life rhythm, job and life stress increase, in addition environmental pollution, food it is dangerous etc. because
The sub-health status of element, people is increasingly severe, has gradually threatened people's lives health.People's life stress is big, life
It is irregular, it does not get enough athletic exercise, constitution is poor, so people are frequently subjected to the invasion of flu, and catch a cold and is divided into anemopyretic cold and wind
Cold flu, the two cause of disease and therapy are neither identical.Wherein anemopyretic cold be wind-heat heresy criminal table, lung qi become estranged caused by.Symptom table
It now weighed for fever, micro- foul wind, distending pain in the head, have sweat, red swelling and pain of throat, cough, phlegm sticks or Huang, nasal obstruction with yellow thick nasal discharge, thirst and liking drink, tongue
Sharp side is red, thin white yellowish fur.Anemopyretic cold is more common in summer and autumn, caused by affection of exogenous wind-heat.
Flu is a kind of multiple respiratory disease, and infectiousness is high, and there are many cold clinical performance, are such as not treated in time, and is held
Easily cause serious complication.In Chinese medicine, flu caused by chill climate change is referred to as exogenous disease, physically weak fire is arrived
Flu is referred to as to really feel.In life, drug and the method for treating flu are varied, and common medicine for oral administration compares human injury
Greatly, maximum especially is stimulated to the mucous membrane of mouth of human body and alimentary canal, some drugs even toxic side effect, the course for the treatment of is long, cannot
Radical cure, although and common drop therapy treatment cycle of having an injection is short, it is quick, easily cause the symptoms such as allergy, price is high
It is expensive, it has not been convenient to.
Summary of the invention
To solve the above problems, the present invention provides a kind of anti-inflammatory heat-clearing cold granules and preparation method thereof, can be used for alleviating
Because food hot gas is got angry, smoking throat inflammation leads to cigarette phlegm, excessive internal heat heat cough in daily life, exempting from for body can be enhanced
Epidemic disease function plays the role of preventing cold.
To achieve the above object, the technical solution adopted by the present invention is that a kind of anti-inflammatory heat-clearing cold granules are provided, by following
Component is made by weight ratio: dayflower 15 ~ 30, Dicliptera chinensis 25 ~ 40, Asiatic plantain 10 ~ 15, cordate houttuynia 15 ~ 20, the sterculia seed 8 ~
16, Siraitia grosvenorii 15 ~ 22, Radix Glycyrrhizae 6 ~ 15, rush 7 ~ 12, rhizoma imperatae 12 ~ 20.
Wherein, a kind of anti-inflammatory heat-clearing cold granules are made by weight ratio of following components: dayflower 20, Dicliptera chinensis 30,
Asiatic plantain 15, cordate houttuynia 20, the sterculia seed 16, Siraitia grosvenorii 22, Radix Glycyrrhizae 15, rush 12, rhizoma imperatae 20.
Wherein, a kind of anti-inflammatory heat-clearing cold granules are made by weight ratio of following components: dayflower 25, Dicliptera chinensis 35,
Asiatic plantain 12, cordate houttuynia 17, the sterculia seed 10, Siraitia grosvenorii 20, Radix Glycyrrhizae 12, rush 10, rhizoma imperatae 15.
Wherein, a kind of anti-inflammatory heat-clearing cold granules are made by weight ratio of following components: dayflower 27, Dicliptera chinensis 32,
Asiatic plantain 13, cordate houttuynia 19, the sterculia seed 13, Siraitia grosvenorii 17, Radix Glycyrrhizae 9, rush 9, rhizoma imperatae 17.
The present invention also provides a kind of preparation methods of anti-inflammatory heat-clearing cold granules, including following preparation step:
(1) pretreatment of raw material: in parts by weight, good dayflower, Dicliptera chinensis, Asiatic plantain, cordate houttuynia, the sterculia seed, sieve are chosen
Chinese fruit, Radix Glycyrrhizae, rush, rhizoma imperatae are cleaned, drained and standby；
(2) it prepares Chinese medicine liquid: above-mentioned raw materials is mixed, add water to cook 2-3 times, each 1-1.5h is filtered later, collects to obtain filtering
Liquid；
(cream is received in (3) concentration: being taken filtered fluid in process (2), is concentrated in multifunctional sphere concentration pan extracting in water, thickening temperature is
100 degree, thick paste is made in concentration time 2h-3h；
(4) thick paste obtained in process (3), the whole grain in oscillating granulator whole grain: are taken；
(5) dry: to take whole grain obtained in process (4), dry 60-120min, drying temperature 60-80 in hot air circulation case
Degree, high temperature drying to moisture content are 2% hereinafter, obtaining dry granular；
(6) it packs: taking dry granular obtained in process (5), after ultraviolet lamp sterilization 30-35min, precisely weighing and bagging is sealed rapidly
Mouthful.
Wherein, in (1) pretreatment of raw material, dayflower is dried spare with salt water immersion taking-up in 1 hour；Asiatic plantain is big with washing
The immersion taking-up in 30 minutes of rice water is dried spare；Dicliptera chinensis with boil Wu Doushui impregnate 5 minutes take out dry it is spare；Cordate houttuynia, which is cleaned, shines
It does spare；The sterculia seed goes after its kernel to dry spare with 20 degree of water temperature immersions.
Wherein, in process (6) packaging, sealing packaging is carried out using far infrared thermal shrinking package machine.
The beneficial effects of the present invention are:
Traditional Chinese medicine composition formula of the invention is reasonable, using dayflower, Dicliptera chinensis as main ingredient, Asiatic plantain, cordate houttuynia, the sterculia seed, sieve
Chinese fruit, rhizoma imperatae etc. are applied in combination for adjuvant, can give full play to the synergistic effect between each drug, have non-stimulated, safety and comfort
Effectively, the advantages that allotment is simple, raw material simply easily takes and without side-effects, with strong points, can effectively help to alleviate because of chill sense
The discomforts such as caused headache, nasal obstruction, runny nose are emitted, avoid having an injection by pain, and there is clearing heat and detoxicating, anti-inflammatory toxin expelling, to prevent catching a cold, feel
Emit heat cough, hot gas is got angry, throat is stained with phlegm, sphagitis swelling and pain, the effect of heart is fidgety, antitumor, cure rate is high nontoxic secondary to be made
With.
Specific embodiment
The present invention is made by weight ratio about a kind of anti-inflammatory heat-clearing cold granules, by following components: dayflower 15 ~ 30,
Dicliptera chinensis 25 ~ 40, Asiatic plantain 10 ~ 15, cordate houttuynia 15 ~ 20, the sterculia seed 8 ~ 16, Siraitia grosvenorii 15 ~ 22, Radix Glycyrrhizae 6 ~ 15, rush 7 ~
12, rhizoma imperatae 12 ~ 20.
A kind of preparation method of the present invention also about anti-inflammatory heat-clearing cold granules, including following preparation step:
(1) pretreatment of raw material: in parts by weight, good dayflower, Dicliptera chinensis, Asiatic plantain, cordate houttuynia, the sterculia seed, sieve are chosen
Chinese fruit, Radix Glycyrrhizae, rush, rhizoma imperatae, dayflower are dried spare with salt water immersion taking-up in 1 hour；Dicliptera chinensis is with boiling black beans water logging
Steep 5 minutes take out dry it is spare；Asiatic plantain with wash rice water impregnate 30 minutes take out dry it is spare；Cordate houttuynia clean dry it is standby
With；The sterculia seed goes after its kernel to dry spare with 20 degree of water temperature immersions；Siraitia grosvenorii, Radix Glycyrrhizae, rush, rhizoma imperatae clean drain it is standby
With；
(2) it prepares Chinese medicine liquid: above-mentioned raw materials is mixed, add water to cook 2-3 times, each 1-1.5h is filtered later, collects to obtain filtering
Liquid；
(3) cream is received in concentration: being taken filtered fluid in process (2), is concentrated in multifunctional sphere concentration pan extracting in water, thickening temperature is
100 degree, thick paste is made in concentration time 2h-3h；
(4) thick paste obtained in process (3), the whole grain in oscillating granulator whole grain: are taken；
(5) dry: to take whole grain obtained in process (4), dry 60-120min, drying temperature 60-80 in hot air circulation case
Degree, high temperature drying to moisture content are 2% hereinafter, obtaining dry granular；
(6) it packs: taking dry granular obtained in process (5), after ultraviolet lamp sterilization 30-35min, precisely weigh rapidly with remote red
Outer heat shrink packing machine carries out sealing packaging.
In above-mentioned operation (2)-(4), the present invention can also be respectively to dayflower, Dicliptera chinensis, Asiatic plantain, cordate houttuynia, fat big
Sea, Siraitia grosvenorii, Radix Glycyrrhizae, rush, rhizoma imperatae are individually added water to cook one by one, and same the decoction of every part of raw material 2-3 times, every time
1-1.5h, individually filtering, collects obtain nine parts of filtered fluids respectively later；Nine parts of filtered fluids are concentrated in multifunctional sphere respectively again
Pot extracting in water concentration, thickening temperature are 100 degree, concentration time 2h-3h, and nine parts of thick pastes are made；After thick paste is mixed, shaking
Put whole grain in granulator；Above-mentioned operation (5) will be carried out after whole grain, finished product can be obtained in (6).
Traditional Chinese medicine composition formula of the invention is reasonable, Asiatic plantain, cordate houttuynia, fat big using dayflower, Dicliptera chinensis as main ingredient
Sea, Siraitia grosvenorii, rhizoma imperatae etc. are applied in combination for adjuvant, can give full play to the synergistic effect between each drug, have non-stimulated, safety
It is comfortable effectively, allotment is simple, raw material simply easily takes and without side-effects, it is with strong points the advantages that, can effectively help to alleviate because of wind
The cold discomforts such as caused headache, nasal obstruction, runny nose of catching a cold, avoid having an injection by pain, and have clearing heat and detoxicating, anti-inflammatory toxin expelling, to prevent sense
Emit, heat cough of catching a cold, hot gas are got angry, throat is stained with phlegm, sphagitis swelling and pain, the effect of heart is fidgety, antitumor, cure rate height is nontoxic
Side effect.
The present invention is described in detail combined with specific embodiments below.
Embodiment one
A kind of anti-inflammatory heat-clearing cold granules are made by weight ratio of following components: dayflower 20, Dicliptera chinensis 30, Asiatic plantain 15,
Cordate houttuynia 20, the sterculia seed 16, Siraitia grosvenorii 22, Radix Glycyrrhizae 15, rush 12, rhizoma imperatae 20.
By above-mentioned parts by weight, chooses and good choose good dayflower, Dicliptera chinensis, Asiatic plantain, cordate houttuynia, fat big
Sea, Siraitia grosvenorii, Radix Glycyrrhizae, rush, rhizoma imperatae are cleaned drained and standby；Above-mentioned raw materials are mixed, are added water to cook 2-3 times, each 1-
1.5h is filtered later, collects to obtain filtered fluid；Extracting in water concentration is made thick paste, last whole grain mix after drying pack to get
Finished product.
Embodiment two
A kind of anti-inflammatory heat-clearing cold granules are made by weight ratio of following components: dayflower 25, Dicliptera chinensis 35, Asiatic plantain 12,
Cordate houttuynia 17, the sterculia seed 10, Siraitia grosvenorii 20, Radix Glycyrrhizae 12, rush 10, rhizoma imperatae 15.
By above-mentioned parts by weight, chooses and good choose good dayflower, Dicliptera chinensis, Asiatic plantain, cordate houttuynia, fat big
Sea, Siraitia grosvenorii, Radix Glycyrrhizae, rush, rhizoma imperatae are cleaned drained and standby；Above-mentioned raw materials are mixed, are added water to cook 2-3 times, each 1-
1.5h is filtered later, collects to obtain filtered fluid；Extracting in water concentration is made thick paste, last whole grain mix after drying pack to get
Finished product.
Embodiment three
A kind of anti-inflammatory heat-clearing cold granules are made by weight ratio of following components: dayflower 27, Dicliptera chinensis 32, Asiatic plantain 13,
Cordate houttuynia 19, the sterculia seed 13, Siraitia grosvenorii 17, Radix Glycyrrhizae 9, rush 9, rhizoma imperatae 17.
By above-mentioned parts by weight, chooses and good choose good dayflower, Dicliptera chinensis, Asiatic plantain, cordate houttuynia, fat big
Sea, Siraitia grosvenorii, Radix Glycyrrhizae, rush, rhizoma imperatae are cleaned drained and standby；Above-mentioned raw materials are mixed, are added water to cook 2-3 times, each 1-
1.5h is filtered later, collects to obtain filtered fluid；Extracting in water concentration is made thick paste, last whole grain mix after drying pack to get
Finished product.
Wherein, effect is as follows the effect of raw material:
Dayflower: sweet in flavor, light, cold in nature, return lung, stomach, bladder meridian.
Dicliptera chinensis: sweet in flavor, slight bitter, cold in nature, return heart, liver, lung channel.
Asiatic plantain: sweet in flavor, cold in nature.Return liver, kidney, bladder meridian.
Cordate houttuynia: acrid flavour, cold nature, return lung, bladder, large intestine channel.
The sterculia seed: sweet in flavor, cold in nature, return lung, large intestine channel.
Siraitia grosvenorii: sweet in flavor, cool in nature, return lung, large intestine channel.
Radix Glycyrrhizae: sweet in flavor, mild-natured, returns spleen, stomach, the heart, lung channel.
Rush: sweet in flavor, light, cold nature, return heart, lung, small intestine, bladder meridian.
Rhizoma imperatae: sweet in flavor, cold in nature, return lung, stomach, bladder meridian.
Test example
Using the anti-inflammatory heat-clearing cold granules being prepared by above-described embodiment as test specimen, random selection 50 is ready to take
With and the experimenter that has caught a cold, and test specimen is distributed to them, result statistics is carried out after 1 month.
Instructions of taking: three times a day, one bag every time, every bag is brewed with 300ml boiled water and drinks.
Through counting, in 50 bit test persons, there are 45 bit test persons unanimously to think after taking this particle, anti inflammation, detumescence and relieving pain, hair
Thermal phenomenon disappears, and sound has restored normally, and after even served 3 days, symptom is substantially reduced, continues to take 7 days, fully recovers, significant effect.
Embodiment of above be only preferred embodiments of the present invention will be described, not to the scope of the present invention into
Row limits, and without departing from the spirit of the design of the present invention, this field ordinary engineering and technical personnel is to technical side of the invention
The various changes and improvements that case is made should all fall into the protection scope that claims of the present invention determines.
Claims (7)
1. a kind of anti-inflammatory heat-clearing cold granules, which is characterized in that be made by weight ratio of following components: dayflower 15 ~ 30, dog
Liver dish 25 ~ 40, Asiatic plantain 10 ~ 15, cordate houttuynia 15 ~ 20, the sterculia seed 8 ~ 16, Siraitia grosvenorii 15 ~ 22, Radix Glycyrrhizae 6 ~ 15, rush 7 ~ 12,
Rhizoma imperatae 12 ~ 20.
2. a kind of anti-inflammatory heat-clearing cold granules according to claim 1, which is characterized in that by weight ratio by following components
It is made: dayflower 20, Dicliptera chinensis 30, Asiatic plantain 15, cordate houttuynia 20, the sterculia seed 16, Siraitia grosvenorii 22, Radix Glycyrrhizae 15, rush 12, white
Lalang grass rhizome 20.
3. a kind of anti-inflammatory heat-clearing cold granules according to claim 1, which is characterized in that by weight ratio by following components
It is made: dayflower 25, Dicliptera chinensis 35, Asiatic plantain 12, cordate houttuynia 17, the sterculia seed 10, Siraitia grosvenorii 20, Radix Glycyrrhizae 12, rush 10, white
Lalang grass rhizome 15.
4. a kind of anti-inflammatory heat-clearing cold granules according to claim 1, which is characterized in that by weight ratio by following components
It is made: dayflower 27, Dicliptera chinensis 32, Asiatic plantain 13, cordate houttuynia 19, the sterculia seed 13, Siraitia grosvenorii 17, Radix Glycyrrhizae 9, rush 9, cogongrass
Root 17.
5. a kind of preparation method of the anti-inflammatory heat-clearing cold granules as described in claim 1 ~ 4, which is characterized in that including making as follows
Standby step:
(1) pretreatment of raw material: in parts by weight, good dayflower, Dicliptera chinensis, Asiatic plantain, cordate houttuynia, the sterculia seed, sieve are chosen
Chinese fruit, Radix Glycyrrhizae, rush, rhizoma imperatae are cleaned, drained and standby；
(2) it prepares Chinese medicine liquid: above-mentioned raw materials is mixed, add water to cook 2-3 times, each 1-1.5h is filtered later, collects to obtain filtering
Liquid；
(3) cream is received in concentration: being taken filtered fluid in process (2), is concentrated in multifunctional sphere concentration pan extracting in water, thickening temperature is
100 degree, thick paste is made in concentration time 2h-3h；
(4) thick paste obtained in process (3), the whole grain in oscillating granulator whole grain: are taken；
(5) dry: to take whole grain obtained in process (4), dry 60-120min, drying temperature 60-80 in hot air circulation case
Degree, high temperature drying to moisture content are 2% hereinafter, obtaining dry granular；
(6) it packs: taking dry granular obtained in process (5), after ultraviolet lamp sterilization 30-35min, precisely weighing and bagging is sealed rapidly
Mouthful.
6. a kind of preparation method of anti-inflammatory heat-clearing cold granules according to claim 5, it is characterised in that: in (1) raw material
In pretreatment, dayflower is dried spare with salt water immersion taking-up in 1 hour；Asiatic plantain is dried with rice water immersion taking-up in 30 minutes is washed
It is spare；Dicliptera chinensis with boil Wu Doushui impregnate 5 minutes take out dry it is spare；Cordate houttuynia clean dry it is spare；20 degree of water of the sterculia seed
Temperature impregnate go after its kernel to dry it is spare.
7. a kind of preparation method of anti-inflammatory heat-clearing cold granules according to claim 5, it is characterised in that: in process (6)
In packaging, sealing packaging is carried out using far infrared thermal shrinking package machine.
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Non-Patent Citations (1)
| Title |
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| 三采文化: "《实用四季养颜经》", 30 September 2009, 汕头大学出版社 * |
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Address after: No.31, Gaoshan village, Wangdong, Pingding Town, Huazhou City, Maoming City, Guangdong Province Applicant after: Liang Hebiao Address before: 525135 Gaoshan Village No. 31, Wangya, Dingping Town, Huazhou City, Maoming City, Guangdong Province Applicant before: Liang Hebiao |
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Application publication date: 20190315 |