CN109464602A - 一种改善眼睛视疲劳的中药贴敷料及其制备方法 - Google Patents

一种改善眼睛视疲劳的中药贴敷料及其制备方法 Download PDF

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CN109464602A
CN109464602A CN201811241209.1A CN201811241209A CN109464602A CN 109464602 A CN109464602 A CN 109464602A CN 201811241209 A CN201811241209 A CN 201811241209A CN 109464602 A CN109464602 A CN 109464602A
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chinese medicine
visual fatigue
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魏坤
胡方斌
莫灿龙
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South China University of Technology SCUT
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Abstract

本发明涉及中药保健领域，具体涉及一种改善眼睛视疲劳的中药贴敷料及其制备方法。该中药贴敷料由以下原料制成：白岌，白芷、没药，决明子，菊花，菟丝子，夏枯草，洋地黄和牛黄。该方法为：称量，清洗；放入真空干燥箱内烘干,然后用粉碎机进行粉碎研磨至粉末状，放入杀菌锅内灭菌；加乙醇溶液，用微波萃取方法连续40℃~60℃萃取三次，萃取液进行离心分离，净浸液浓缩至相对密度为1.00~1.20的稠膏,冷凝后涂薄层于无菌纱布眼贴，展开，即制成中药眼贴敷料。本发明能快速缓解视疲劳，具有清热解毒，明目消炎的功效，并且能有效缓解眼酸，眼胀，眼痛，眼干等症状，是可有效改善眼睛视疲劳的安全有效中药敷料。

Description

一种改善眼睛视疲劳的中药贴敷料及其制备方法
技术领域
本发明涉及一种中药组合物，尤其涉及一种改善眼睛视疲劳的中药贴敷料及其制备方法。
背景技术
视疲劳是一种有多种原因引发的眼部疾病，用眼不能持久，长时间用眼会产生眼睛干涩、酸痛、肿胀，重影现象及短时间视力模糊等常见的症状，严重者还会出现恶心、头痛、眩晕、颈椎酸痛等症状。随着科技的发展，工作生活压力的与日俱增，生活节奏的加快以及电脑，电视，视频的普及，视疲劳已经成为困扰大部分人群的普遍症状。长时间的工作或学习使人们用眼程度超负荷，导致反复视疲劳可能还导致其他眼病的发生，如电脑视觉综合征，屈光不正，VDT综合征等。因此，如何解决人们日常对眼睛的有效护理问题,保护好心灵之窗已成为越来越多人们的迫切需求，同时也是该领域当前函待解决的难题之一。
发明内容
针对现有技术存在的不足,本发明所要解决的技术问题是,提供一种快速缓解视疲劳，具有清热解毒，明目消炎的功效，并且能有效缓解眼酸，眼胀，眼痛，眼干等症状，是可有效改善眼睛视疲劳的安全有效中药敷料及制备方法。
为解决上述技术问题,本发明所采取的技术方案如下。
一种改善眼睛视疲劳的中药贴敷料，按照质量份数计，由以下原料制成：白岌5～10份，白芷5～10份、没药1～20份，决明子15～20 份，菊花1～8份，菟丝子5～20份，夏枯草5～20份，洋地黄5～20份和牛黄1～5份。
优选地，按照重量计份，配比为：白岌5份，白芷5份、没药3 份，决明子20份，菊花5份，菟丝子15份，夏枯草10份，洋地黄 17份和牛黄5份。
一种改善眼睛视疲劳的中药贴敷料的制备方法，包括如下步骤：
(1)称量，清洗：按比例称取中药白岌，白芷，没药，决明子，菊花，菟丝子，夏枯草，洋地黄和牛黄，然后用纯净水洗净；
(2)烘干，粉碎：将步骤(1)中洗净的各味中药放入真空干燥箱内烘干, 然后用粉碎机进行粉碎研磨至粉末状,粉碎研磨粒度为50-200目,将制得的粉末状物料放入杀菌锅内灭菌，灭菌温度为60℃～100℃，灭菌10-30分钟；
(3)加60％-85％乙醇溶液500-1000ml，用微波萃取方法连续40℃～60℃萃取三次，萃取液进行离心分离，净浸液浓缩至相对密度为1.00～1.20 的稠膏,冷凝后涂薄层于无菌纱布眼贴，展开，即制成中药眼贴敷料。
与现有技术相比，本发明具有如下优势：
长时间的工作或学习使人们用眼程度超负荷，导致反复视疲劳可能还导致其他眼病的发生，本发明提供一种快速缓解视疲劳的中药贴敷料制备方法，从不同方面对改善视疲劳起到一定作用，具有清热解毒，明目消炎的功效，并且能有效缓解眼酸，眼胀，眼痛，眼干等症状，还具有抗炎抗氧化的功能。经试验证明，该中药敷料组合物配伍合理，安全有效，无毒副作用，可改善眼睛视疲劳人群的亚健康状态。
具体实施方式
下面结合具体实施例对本发明作进一步地具体详细描述，但本发明的实施方式不限于此，对于未特别注明的工艺参数，可参照常规技术进行。
实施例1
(1)称量，清洗：按比例称取中药白岌5g，白芷5g、没药3g，决明子20g，菊花5g，菟丝子15g，夏枯草10g，洋地黄17g，牛黄5g，然后用纯净水洗净；
(2)烘干，粉碎：将步骤(1)中洗净的各味中药放入真空干燥箱内烘干，然后用粉碎机进行粉碎研磨至粉末状，粉碎研磨粒度为50-200目,将制得的粉末状物料放入杀菌锅内灭菌，灭菌温度为80℃，灭菌5分钟，取出备用；
(3)加70％乙醇溶液500ml，用微波萃取方法连续50℃萃取三次，萃取液进行离心分离，净浸液浓缩至相对密度为1.00～1.20的稠膏，冷凝后涂薄层于无菌纱布眼贴，展开，即制成中药眼贴敷料。
本实施方式制备的贴敷眼睑缓解视疲劳的贴敷制剂的眼贴，本实施方式选择年龄10～55岁中100人，患者年龄最小10岁，最大55 岁，平均年龄31.66士16.81岁，患有眼困倦、畏光、酸痛、流泪、异物感、眼干涩、眼痉挛症状的视疲劳症状患者，进行持续10天贴敷改善眼睛视疲劳的中药贴敷料，患者每天闭眼后将贴敷眼睑缓解视疲劳的贴敷制剂的眼贴贴于眼睛上，每次2贴，每日2次，每次 10～30min。使用10日后患者症状情况见下表所示
本实施方式制备的贴敷眼睑缓解视疲劳的贴敷制剂的眼贴,对眼困倦、畏光、酸痛、流泪、异物感、眼干涩、眼痉挛都有明显的治疗效果。对眼困倦的治愈率100％，畏光的治愈率90.2％，酸痛的治愈率88％,流泪的治愈率95％，异物感的治愈率93.3％，眼干涩治愈率 96％，眼痉挛的治愈率100％。
实施例2
(1)称量，清洗：按比例称取中药白岌5g，白芷10g、没药5g，决明子15g，菊花5g，菟丝子10g，夏枯草5g，洋地黄12g，牛黄5g，然后用纯净水洗净；
(2)烘干，粉碎：将步骤(1)中洗净的各味中药放入真空干燥箱内烘干，然后用粉碎机进行粉碎研磨至粉末状，粉碎研磨粒度为50-200目,将制得的粉末状物料放入杀菌锅内灭菌，灭菌温度为70℃，灭菌5分钟，取出备用；
(3)加70％乙醇溶液500ml，用微波萃取方法连续50℃萃取三次，萃取液进行离心分离，净浸液浓缩至相对密度为1.00～1.20的稠膏，冷凝后涂薄层于无菌纱布眼贴，展开，即制成中药眼贴敷料。
实施例3
(1)称量，清洗：按比例称取中药白岌8g，白芷8g、没药10g，决明子18g，菊花3g，菟丝子10g，夏枯草17g，洋地黄10g，牛黄4g，然后用纯净水洗净；
(2)烘干，粉碎：将步骤(1)中洗净的各味中药放入真空干燥箱内烘干，然后用粉碎机进行粉碎研磨至粉末状，粉碎研磨粒度为50-200目,将制得的粉末状物料放入杀菌锅内灭菌，灭菌温度为70℃，灭菌5分钟，取出备用；
(3)加70％乙醇溶液800ml，用微波萃取方法连续50℃萃取三次，萃取液进行离心分离，净浸液浓缩至相对密度为1.00～1.20的稠膏，冷凝后涂薄层于无菌纱布眼贴，展开，即制成中药眼贴敷料。
实施例4
改善眼睛视疲劳的中药贴敷料
(1)称量，清洗：按比例称取中药白岌10g，白芷8g、没药10g，决明子15g，菊花5g，菟丝子10g，夏枯草15g，洋地黄10g，牛黄4g，然后用纯净水洗净；
(2)烘干，粉碎：将步骤(1)中洗净的各味中药放入真空干燥箱内烘干，然后用粉碎机进行粉碎研磨至粉末状，粉碎研磨粒度为50-200目,将制得的粉末状物料放入杀菌锅内灭菌，灭菌温度为70℃，灭菌5分钟，取出备用；
(3)加70％乙醇溶液1000ml，用微波萃取方法连续50℃萃取三次，萃取液进行离心分离，净浸液浓缩至相对密度为1.1的稠膏，冷凝后涂薄层于无菌纱布眼贴，展开，即制成中药眼贴敷料。

Claims (4)

1.一种改善眼睛视疲劳的中药贴敷料，其特征在于，按照质量份数计，由以下原料制成：白岌5~10份、白芷5~10份、没药1~20份、决明子15~20份、菊花1~8份、菟丝子5~20份、夏枯草5~20份、洋地黄5~20份和牛黄1~5份。
2.根据权利要求1所述改善眼睛视疲劳的中药贴敷料，其特征在于，按照重量计份，配比为：白岌5份、白芷5份、没药3份、决明子20份、菊花5份、菟丝子15份、夏枯草10份、洋地黄17份和牛黄5份。
3.权利要求1所述改善眼睛视疲劳的中药贴敷料的制备方法，其特征在于，包括如下步骤：
(1)称量，清洗：按比例称取中药白岌、白芷、没药、决明子、菊花、菟丝子、夏枯草、洋地黄和牛黄，然后用纯净水洗净；
(2)烘干，粉碎：将步骤(1)中洗净的各味中药放入真空干燥箱内烘干,然后用粉碎机进行粉碎研磨至粉末状,粉碎研磨粒度为50-200目, 将制得的粉末状物料放入杀菌锅内灭菌，灭菌温度为60℃~100℃，灭菌10-30分钟；
(3) 加乙醇溶液，用微波萃取方法连续40℃~60℃萃取三次，萃取液进行离心分离，净浸液浓缩至相对密度为1.00~1.20的稠膏, 冷凝后涂薄层于无菌纱布眼贴，展开，即制成中药眼贴敷料。
4.根据权利要求3所述改善眼睛视疲劳的中药贴敷料的制备方法，其特征在于，步骤（3）中，所述乙醇溶液的体积百分比浓度为60%-85%，所述乙醇的添加量为500-1000ml。
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