CN109453270A - Rich in grape seed oil traditional Chinese medicine extract composition and purposes - Google Patents
Rich in grape seed oil traditional Chinese medicine extract composition and purposes Download PDFInfo
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- CN109453270A CN109453270A CN201811342113.4A CN201811342113A CN109453270A CN 109453270 A CN109453270 A CN 109453270A CN 201811342113 A CN201811342113 A CN 201811342113A CN 109453270 A CN109453270 A CN 109453270A
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- seed oil
- grape seed
- benexate hydrochloride
- chinese medicine
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- A—HUMAN NECESSITIES
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
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- A61K36/232—Angelica
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Abstract
The present invention relates to health care product manufacture fields.The invention discloses one kind to be rich in grape seed oil traditional Chinese medicine extract composition, it is made of following proportion raw material: grape seed oil-Benexate Hydrochloride 2.25-112.5g, ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g, Radix Astragali 550g.The present invention using grape seed oil have the function of it is anti-oxidant, skin nutrition cell, prevent pachylosis and angling, with with benefiting qi and removing blood stasis, menstruation-regulating and speckle-dispelling, nourish the Chinese traditional medicine composition of skin effect, damage to prevention and treatment free radical to skin, it promotes blood circulation, promoting skin cell development has preferable assisting in preventing and treating effect.New Pharmaceutical composition is formed by the extract of grape seed oil-Benexate Hydrochloride and Chinese traditional medicine composition of the present invention, grape seed oil ingredient and traditional Chinese medicine ingredients beneficial effect can be given full play to.Routinely tablet, capsule, granule or wine product are made as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics in technique to the composition.
Description
Technical field
The present invention relates to pharmaceutical preparation and/or health food manufacture fields, and in particular to a kind of to be pasted by grape seed oil-β-ring
Inclusion compounds and traditional Chinese medicine extract composition and purposes.
Background technique
Since modern people's rhythm of life is accelerated, life stress is big, the variation of life pattern, and environmental pollution is to the modern times in addition
Increasing trend is also presented in some distinctive diseases accordingly in life.Such as because of insufficiency of vital energy and blood, the institutes such as qi and blood retardance or qi deficiency to blood stasis
The endocrine disturbance of cause, chloasma (blackish facial patch), freckle, butterfly macules, the yellow cases such as coarse of skin surface obviously increase, until current
There is not the therapeutic agent of definite curative effect yet.There is anti-oxidant, skin nutrition cell using grape seed oil, prevent pachylosis and angle
The function of change, in conjunction with the traditional traditional Chinese medical theory in China, with benefiting qi and removing blood stasis, menstruation-regulating and speckle-dispelling nourishes the Chinese traditional medicine composition of skin,
This active material of grape seed oil and traditional medicine and modern pharmaceutical technology are organically combined, a kind of new medicine group is formed
Object is closed, the composition is enable to play the preventive and therapeutic effect of auxiliary in the treatment of above-mentioned disease.
Summary of the invention
It is provided by the invention rich in grape seed oil traditional Chinese medicine extract composition be by grape seed oil-Benexate Hydrochloride with
Chinese medical extract is made.
The object of the invention is also to provide the compositions in preparation auxiliary adjustment benefiting qi and removing blood stasis, menstruation-regulating and speckle-dispelling, nourishes flesh
As the purposes for preparing health care product in skin drug.
The object of the invention is also to provide the compositions in the purposes for preparing the additive in cosmetics.
It is provided by the invention to be rich in grape seed oil traditional Chinese medicine extract composition, which is characterized in that it is by following proportion
Raw material is made: grape seed oil-Benexate Hydrochloride 2.25-112.5g, ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g, Radix Astragali
550g,
Preparation method is as follows: taking ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g, 10 times of medicinal material weight ratio of Radix Astragali 550g addition is dense
Degree is the ethyl alcohol of 75%v/v, is impregnated 168 hours at 38 DEG C -40 DEG C, leaching soaked extracting solution, and recycling ethyl alcohol obtains leaching liquor guarantor
It deposits spare, the dregs of a decoction is separately pressed to 8 times of medicinal material weight, 5 times, 3 extraordinarily water boiling and extraction 3 times respectively, decocting extraction time is for the first time 2
Hour, second 1 hour, third time 0.5 hour, merging decocted extracting solution three times, filtered, be concentrated into specific gravity be 1.0 it is dense
When contracting liquid, then with the leaching liquor after above-mentioned recycling ethyl alcohol merge mixing, through it is dry to water content be 4-5%, obtain Chinese medical extract,
Grape seed oil-Benexate Hydrochloride is mixed with Chinese medical extract separately, is stirred evenly, sieving mentions to get grape seed oil Chinese medicine
Take compositions；Grape seed oil-the Benexate Hydrochloride is made by following methods: by grape seed oil: beta-cyclodextrin
Weight ratio is 1:4.5 ratio, weighs the aqueous solution that beta-cyclodextrin is configured to 4.5% by weight percentage, heating stirring make it is molten, to
Solution, which is cooled to room temperature, is added grape seed oil, is put into ultrasonic wave pond, under the conditions of temperature is 28-32 DEG C, sonic oscillation
25min, taking-up, which is set in refrigerator, places 24 hours, filters, and discards filtrate, and filter residue takes out, sieving in the dry 4.5h of 40 DEG C of blowings,
Up to grape seed oil-Benexate Hydrochloride.
It is currently preferred to be rich in grape seed oil traditional Chinese medicine extract composition, which is characterized in that it is by following proportion
Raw material is made: grape seed oil-Benexate Hydrochloride 6.75-90g, ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g, Radix Astragali 550g.
The present invention it is further preferred be rich in grape seed oil traditional Chinese medicine extract composition, which is characterized in that it is by following
The raw material of proportion is made: grape seed oil-Benexate Hydrochloride 15.75-67.5g, ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g,
Radix Astragali 550g.
Heretofore described water is purified water when not making certain illustrated.
Routinely tablet, capsule, granule is made as the purposes for preparing health care product in technique to the pharmaceutical composition.
The pharmaceutical composition is as the purposes for preparing wine product.
Purposes of the pharmaceutical composition as the additive prepared in cosmetics.
The seed that grape seed oil (Grapeseed Oil) is vitaceae grape Vitis vini fera L. extracts
Object, the natural faint yellow or light green in beautiful, be in base oil quite welcome and effect it is tall and erect one of kind.Grape
What seed was spoken approvingly of the most is important element, i.e. linolenic acid and proanthocyanidin containing there are two types of, and wherein linolenic acid is needed by human
And the fatty acid that cannot be synthesized for human body, have and resist free radical, elasticity that is anti-aging, strengthening the circulatory system and other effects,
And proanthocyanidin has protection blood vessel elasticity, cholesterol is prevented to hoard on vascular wall and other effects.Grape seed oil has natural nothing
The characteristic of poison, therefore children, pregnant woman, old man and sportsman are all applicable in.
Grape pip oil content is about 14%-17%, and unsaturated fatty acid content reaches 90% or more in seed oil, mainly at
Dividing is linoleic acid.In oil containing VitAVitE, vitamin D, vitamin K, citrin and calcium, zinc, iron, magnesium, copper,
Potassium, sodium, manganese etc., have nutrition cranial nerve cell, adjust vegetative nerve, reduce serum cholesterol, softening blood vessel, reduce blood pressure,
It reduces blood viscosity and prevents the various biological effectiveness such as thrombosis, also there is anti-oxidant, anti-aging, promote upgrowth and development of children
Etc. physiological actions.Grape seed oil is suitable for various crowds, and it is edible to be particularly suitable for the middle-aged and the old；Grape seed oil external-use skin care, not only
It can be absorbed through skin, skin nutrition cell, prevent pachylosis and angling, and extremely lubricious salubrious, it is nonirritant, it is a kind of
Good natural skin care agent.
Have been reported that the action and efficacy of grape seed oil:
(1) anti-oxidant, lighten the stain (2) and adjust dry skin caused by endocrine disorder, reduce melanin, skin whitening dispels
Chloasma；(3) cell division and regeneration are stimulated, cells of superficial layer is activated, reduces wrinkle, is delayed senescence；(4) inhibit and remove
Interior free yl plays the antianaphylactic effect of anticancer.(5) effect of anti-prostate cancer, anti-liver neoplasm can also fight nerve
The damage of system.
Target user: (1) needs crowd that is anti-oxidant, delaying senescence.(2) need beauty, keep skin whitening, be moist,
The women of elasticity.(3) colour of skin is bad, gloomy, chloasma, relaxation, wrinkle.(4) Patients with Cardiovascular/Cerebrovascular Diseases.(5) allergic constitution
Person.(6) personage of computer, mobile phone and TV is used for a long time.
Ginseng, sweet, slight bitter, tepor.Returns spleen, lung, heart kidney channel.It with replenish vital energy, restore pulse, and strengthen and remove vital energy, reinforces the spleen to benefit the lung, promotes the production of body fluid
Blood-nourishing, tranquilize the mind and promote the intelligence function.Ginseng reinforces vital energy, and vigour is filled, and the motive must support, and the mind obtains rather, intelligence obtain it is clever, and have calm the nerves benefit
The effect of intelligence, for treating deficiency of heart-QI or heart kidney qi deficiency, the insomnia of the insufficiency of heart and spleen, amnesia etc..Ginseng sweet temperature, reinforces vital energy,
QI invigorating has the benefits of qi-blood tonifying with green blood, therefore can be used and control deficiency of spleen-QI and stomach-QI, changes source deficiency, the card of blood deficiency chlorosis.
Radix Angelicae Sinensis, sweet, acrid, warm.Return liver, the heart, the spleen channel.With replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels function is used for blood
Empty sallow, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, intestinal dryness is just
It is secret.The sweet temperature of Radix Angelicae Sinensis, blood-nourishing qi-restoratives, for good medicine of enriching blood, thus it is available control heart-liver blood deficiency, color is sallow, dizziness palpitaition.
Rhizome of chuanxiong, it is acrid in flavour and warm in nature.Return liver, gallbladder, pericardium channel.With blood-activating and qi-promoting, wind-expelling pain-stopping function.The pungent scattered temperature of rhizome of chuanxiong is logical, function
Blood-activating and qi-promoting has the title of " gas medicine in blood " (" collected statements on the herbal foundation ").Both promoting blood circulation was promoted blood circulation, kind to control heart arteries and veins stasis blocking, chest impediment and cardialgia；Again
Promote breath and open depression analgesic, the sternal rib shouting pain by stagnation of QI due to depression of the liver are multi-purpose.Rhizome of chuanxiong is good at " lower menstruation regulating water " (" collected statements on the herbal foundation "), promoting blood circulation is adjusted
Through the excellent key medicine for cards such as irregular menstruation, dysmenorrhea, menostasis；Yi Zhi abdominal mass and abdominal pain, the function with promoting blood circulation, disease eliminating powder junction.
Radix Astragali, sweet, tepor.Return lung, the spleen channel.With tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, shengjin nourishing, row is stagnant to be led to
Numbness, pus draining and toxin expelling, expelling pus and promoting granulation effect is out of strength for qi and blood, anorexia and loose stool, the sinking of qi of middle-jiao, diarrhea rectal prolapse, uterine bleeding of having blood in stool, table
Empty spontaneous perspiration, deficiency of vital energy and edema, Heat Diabetes, the sallow card of the deficiency of vital energy.The sweet tepor of Radix Astragali, benefiting qi and raising yang, lid Yin grows while yang is generating, the prosperous blood of gas
It is raw, therefore have the function of qi-supplementing, blood-engendering, long to be used for overstrain internal injury, gas loses the deficiency of blood, and deficiency of blood sun is floating, the hot flushing of flesh, the deficiency of blood of the big inability of arteries and veins
Fever card.And worry beyond measure, internal lesion caused by overexertion heart spleen, deficiency of qi and blood, sallow complexion, palpitation and insomnia person.
Above 4 kinds of Chinese medicinal compositions prepare extract, prove there is benefiting qi and removing blood stasis according to traditional Chinese medical theory, menstruation-regulating and speckle-dispelling is grown
Skin effect is supported, by modern Chinese herbal medicine theoretical research, if Radix Angelicae Sinensis is one of main ingredient in component, effective component ferulic acid be can be reduced
H2O2Content, and inhibit oxidation reaction and radical reaction in conjunction with phosphatidyl-ethanolamine, damage of the antagonism free radical to tissue,
It promotes blood circulation, promotes the effect of skin cell development.Free radical can not only be quenched in ferulic acid.But also it is raw to be adjustable human body
Reason mechanism inhibits the enzyme generated free radicals, promotes the generation for removing the enzyme of free radical.
Using grape seed oil-Benexate Hydrochloride active constituent and Chinese traditional medicine composition extract can generate heterogeneity,
The synergistic therapeutic action of different role mechanism can strengthen the anti-oxidant and effect of scavenging radical of its drug.The present invention utilizes Portugal
Grape seed oil have the function of it is anti-oxidant, skin nutrition cell, prevent pachylosis and angling, and with benefiting qi and removing blood stasis, menstruation-regulating and speckle-dispelling,
The Chinese traditional medicine composition for nourishing skin effect, the damage to prevention and treatment free radical to skin, promotes blood circulation, and promotes skin cell development
With preferable assisting in preventing and treating effect.Pass through the extract group of grape seed oil-Benexate Hydrochloride and Chinese traditional medicine composition of the present invention
The Pharmaceutical composition of Cheng Xin can give full play to grape seed oil ingredient and traditional Chinese medicine ingredients beneficial effect, especially increase grape
Seed oil have effects that it is anti-oxidant, skin nutrition cell, prevent pachylosis and angling, enhance drug to skin injury, color
Spot and cutaneous pigmentation etc. have good conditioning functions, are pharmaceutical composition of the present invention in health food, cosmetics
Using providing theoretical basis.Especially anti-oxidant, removing free radical, nutrition skin and physical function conditioning functions are more aobvious
It writes, therefore product both can be used as health food and take orally edible or drink, and also can be used as natural beauty skin care product external application.This
Invention overcomes the undesirable problem of current Chinese traditional medicine composition component and effect, and product is easy to use, good in taste, technique letter
Single, high production efficiency, quality is stablized, and can be widely used for the production of health care product, wine product, cosmetics.
Pharmaceutical composition of the invention can according to need and be configured to different peroral dosage forms.It can be by Pharmaceutical composition
It is hybridly prepared into tablet with pharmaceutically acceptable auxiliary material, capsule, granule, wine product etc., wherein capsule can be prepared into
Soft capsule and hard capsule；The wherein preferred effervescent tablet of tablet, chewable tablets, buccal tablet, because of effervescent tablet, chewable tablets, buccal tablet
There is following advantage compared with conventional tablet: (1) convenient to take, chewable clothes, buccal, Ke Huashui, due to preparing these tablets
A certain amount of sugared part will be added as excipient, thus in good taste, people gladly take, and effervescent tablet adds after water self-dissolving like one
Cup beverage, makes people be happy to drink；(2) absorption is fast, because direct oral cavity or bubble drink ionize drug ingedient, is allowed to absorb fastly,
Bioavilability is high；(3) easy to carry, convenient transportation；Wherein the wine product can be made into white wine, grape wine, yellow rice wine and beer
Product.Pharmaceutical composition of the invention can also be configured to cosmetics as needed.
Specific embodiment
It is that the present invention is further illustrated, but does not constitute any limit to the scope of the present invention by following embodiment
System.
Embodiment 1
Preparation rich in grape seed oil traditional Chinese medicine extract composition
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.5% to get Chinese medical extract, weighs Portugal
Grape seed oil-Benexate Hydrochloride 112.5g is mixed with above-mentioned Chinese medical extract, is stirred evenly, sieving to get；The grape
Seed oil-Benexate Hydrochloride is made by following methods: weigh beta-cyclodextrin 112.5g and add water to 2500g, heating stirring make it is molten,
25g grape seed oil is added when solution is cooled to room temperature, is put into ultrasonic wave pond, under the conditions of temperature is 28 DEG C, sonic oscillation
25min then takes out to set and place in refrigerator for 24 hours, and filtering discards filtrate, and filter residue is dried under the conditions of 40 DEG C dries 4.5h, takes
Out, sieving is to get grape seed oil-Benexate Hydrochloride.
It is described rich in grape seed oil traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 2
Preparation rich in grape seed oil traditional Chinese medicine extract composition
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.5% to get Chinese medical extract；Weigh Portugal
Grape seed oil-Benexate Hydrochloride 2.25g is mixed with above-mentioned Chinese medical extract, is stirred evenly, sieving to get；The grape
Seed oil-Benexate Hydrochloride is made by following methods: weigh beta-cyclodextrin 2.25g and add water to 50g, heating stirring make it is molten, to
0.5g grape seed oil is added when solution is cooled to room temperature, is put into ultrasonic wave pond, under the conditions of temperature is 32 DEG C, sonic oscillation
25min then takes out to set and place in refrigerator for 24 hours, and filtering discards filtrate, and filter residue is dried under the conditions of 40 DEG C dries 4.5h, takes
Out, sieving is to get grape seed oil-Benexate Hydrochloride.
It is described rich in grape seed oil traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 3
Preparation rich in grape seed oil traditional Chinese medicine extract composition
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.0% to get Chinese medical extract；Weigh Portugal
Grape seed oil-Benexate Hydrochloride 67.5g is mixed with above-mentioned Chinese medical extract, is stirred evenly, sieving to get；The grape
Seed oil-Benexate Hydrochloride is made by following methods: weigh beta-cyclodextrin 67.5g and add water to 1500g, heating stirring make it is molten,
15g grape seed oil is added when solution is cooled to room temperature, is put into ultrasonic wave pond, under the conditions of temperature is 30 DEG C, sonic oscillation
25min then takes out to set and place in refrigerator for 24 hours, and filtering discards filtrate, and filter residue is dried under the conditions of 40 DEG C dries 4.5h, takes
Out, sieving is to get grape seed oil-Benexate Hydrochloride.
It is described rich in grape seed oil traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 4
Preparation rich in grape seed oil traditional Chinese medicine extract composition
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 38 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.8% to get Chinese medical extract；Weigh Portugal
Grape seed oil-Benexate Hydrochloride 6.75g is mixed with above-mentioned Chinese medical extract, is stirred evenly, sieving to get；The grape
Seed oil-Benexate Hydrochloride is made by following methods: weigh beta-cyclodextrin 6.75g and add water to 150g, heating stirring make it is molten, to
1.5g grape seed oil is added when solution is cooled to room temperature, is put into ultrasonic wave pond, under the conditions of temperature is 29 DEG C, sonic oscillation
25min then takes out to set and place in refrigerator for 24 hours, and filtering discards filtrate, and filter residue is dried under the conditions of 40 DEG C dries 4.5h, takes
Out, sieving is to get grape seed oil-Benexate Hydrochloride.
It is described rich in grape seed oil traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 5
Preparation rich in grape seed oil traditional Chinese medicine extract composition
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 38 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 5.0% to get Chinese medical extract；Weigh Portugal
Grape seed oil-Benexate Hydrochloride 90g is mixed with above-mentioned Chinese medical extract, is stirred evenly, sieving to get；The grape pip
Oil-Benexate Hydrochloride is made by following methods: weigh beta-cyclodextrin 90g and add water to 2000g, heating stirring make it is molten, to molten
20g grape seed oil is added when liquid is cooled to room temperature, is put into ultrasonic wave pond, under the conditions of temperature is 28 DEG C, sonic oscillation
25min then takes out to set and place in refrigerator for 24 hours, and filtering discards filtrate, and filter residue is dried under the conditions of 40 DEG C dries 4.5h, takes
Out, sieving is to get grape seed oil-Benexate Hydrochloride.
It is described rich in grape seed oil traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 6
Preparation rich in grape seed oil traditional Chinese medicine extract composition
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 38 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 5.0% to get Chinese medical extract；Weigh Portugal
Grape seed oil-Benexate Hydrochloride 11.25g is mixed with above-mentioned Chinese medical extract, is stirred evenly, sieving to get；The grape
Seed oil-Benexate Hydrochloride is made by following methods: weigh beta-cyclodextrin 11.25g and add water to 250g, heating stirring make it is molten,
2.5g grape seed oil is added when solution is cooled to room temperature, is put into ultrasonic wave pond, under the conditions of temperature is 31 DEG C, sonic oscillation
25min then takes out to set and place in refrigerator for 24 hours, and filtering discards filtrate, and filter residue is dried under the conditions of 40 DEG C dries 4.5h, takes
Out, sieving is to get grape seed oil-Benexate Hydrochloride.
It is described rich in grape seed oil traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 7
Preparation rich in grape seed oil traditional Chinese medicine extract composition
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 42 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.0% to get Chinese medical extract；Weigh Portugal
Grape seed oil-Benexate Hydrochloride 76.5g is mixed with above-mentioned Chinese medical extract, is stirred evenly, sieving to get；The grape
Seed oil-Benexate Hydrochloride is made by following methods: weigh beta-cyclodextrin 76.5g and add water to 1700g, heating stirring make it is molten,
17g grape seed oil is added when solution is cooled to room temperature, is put into ultrasonic wave pond, under the conditions of temperature is 29 DEG C, sonic oscillation
25min then takes out to set and place in refrigerator for 24 hours, and filtering discards filtrate, and filter residue is dried under the conditions of 40 DEG C dries 4.5h, takes
Out, sieving is to get grape seed oil-Benexate Hydrochloride.
It is described rich in grape seed oil traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 8
Preparation rich in grape seed oil traditional Chinese medicine extract composition
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 42 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.5% to get Chinese medical extract；Weigh Portugal
Grape seed oil-Benexate Hydrochloride 15.7g is mixed with above-mentioned Chinese medical extract, is stirred evenly, sieving to get；The grape
Seed oil-Benexate Hydrochloride is made by following methods: weigh beta-cyclodextrin 15.7g and add water to 350g, heating stirring make it is molten, to
3.5g grape seed oil is added when solution is cooled to room temperature, is put into ultrasonic wave pond, under the conditions of temperature is 30 DEG C, sonic oscillation
25min then takes out to set and place in refrigerator for 24 hours, and filtering discards filtrate, and filter residue is dried under the conditions of 40 DEG C dries 4.5h, takes
Out, sieving is to get grape seed oil-Benexate Hydrochloride.
It is described rich in grape seed oil traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 9
Preparation rich in grape seed oil traditional Chinese medicine extract composition
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 42 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.5% to get Chinese medical extract；Weigh Portugal
Grape seed oil-Benexate Hydrochloride 45g is mixed with above-mentioned Chinese medical extract, is stirred evenly, sieving to get；The grape pip
Oil-Benexate Hydrochloride is made by following methods: weigh beta-cyclodextrin 45g and add water to 1000g, heating stirring make it is molten, to molten
10g grape seed oil is added when liquid is cooled to room temperature, is put into ultrasonic wave pond, under the conditions of temperature is 29 DEG C, sonic oscillation
25min then takes out to set and place in refrigerator for 24 hours, and filtering discards filtrate, and filter residue is dried under the conditions of 40 DEG C dries 4.5h, takes
Out, sieving is to get grape seed oil-Benexate Hydrochloride.
It is described rich in grape seed oil traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Claims (7)
1. one kind is rich in grape seed oil traditional Chinese medicine extract composition, which is characterized in that it is made of the raw material of following proportion: Portugal
Grape seed oil-Benexate Hydrochloride 2.25-112.5g, ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g, Radix Astragali 550g,
Preparation method is as follows: taking ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g, 10 times of medicinal material weight ratio of Radix Astragali 550g addition is dense
Degree is the ethyl alcohol of 75%v/v, is impregnated 168 hours at 38 DEG C -40 DEG C, leaching soaked extracting solution, and recycling ethyl alcohol obtains leaching liquor guarantor
It deposits spare, the dregs of a decoction is separately pressed to 8 times of medicinal material weight, 5 times, 3 extraordinarily water boiling and extraction 3 times respectively, decocting extraction time is for the first time 2
Hour, second 1 hour, third time 0.5 hour, merging decocted extracting solution three times, filtered, be concentrated into specific gravity be 1.0 it is dense
When contracting liquid, then with the leaching liquor after above-mentioned recycling ethyl alcohol merge mixing, through it is dry to water content be 4-5%, obtain Chinese medical extract,
Grape seed oil-Benexate Hydrochloride is mixed with Chinese medical extract separately, is stirred evenly, sieving mentions to get grape seed oil Chinese medicine
Take compositions；Grape seed oil-the Benexate Hydrochloride is made by following methods: by grape seed oil: beta-cyclodextrin
Weight ratio is 1:4.5 ratio, weighs the aqueous solution that beta-cyclodextrin is configured to 4.5% by weight percentage, heating stirring make it is molten, to
Solution, which is cooled to room temperature, is added grape seed oil, is put into ultrasonic wave pond, under the conditions of temperature is 28-32 DEG C, sonic oscillation
25min, taking-up, which is set in refrigerator, places 24 hours, filters, and discards filtrate, and filter residue takes out, sieving in the dry 4.5h of 40 DEG C of blowings,
Up to grape seed oil-Benexate Hydrochloride.
2. one kind is rich in grape seed oil traditional Chinese medicine extract composition, which is characterized in that it is made of the raw material of following proportion: Portugal
Grape seed oil-Benexate Hydrochloride 6.75-90g, ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g, Radix Astragali 550g,
Preparation method is as follows: taking ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g, 10 times of medicinal material weight ratio of Radix Astragali 550g addition is dense
Degree is the ethyl alcohol of 75%v/v, is impregnated 168 hours at 38 DEG C -40 DEG C, leaching soaked extracting solution, and recycling ethyl alcohol obtains leaching liquor guarantor
It deposits spare, the dregs of a decoction is separately pressed to 8 times of medicinal material weight, 5 times, 3 extraordinarily water boiling and extraction 3 times respectively, decocting extraction time is for the first time 2
Hour, second 1 hour, third time 0.5 hour, merging decocted extracting solution three times, filtered, be concentrated into specific gravity be 1.0 it is dense
When contracting liquid, then with the leaching liquor after above-mentioned recycling ethyl alcohol merge mixing, through it is dry to water content be 4-5%, obtain Chinese medical extract,
Grape seed oil-Benexate Hydrochloride is mixed with Chinese medical extract separately, is stirred evenly, sieving mentions to get grape seed oil Chinese medicine
Take compositions；Grape seed oil-the Benexate Hydrochloride is made by following methods: by grape seed oil: beta-cyclodextrin
Weight ratio is 1:4.5 ratio, weighs the aqueous solution that beta-cyclodextrin is configured to 4.5% by weight percentage, heating stirring make it is molten, to
Solution, which is cooled to room temperature, is added grape seed oil, is put into ultrasonic wave pond, under the conditions of temperature is 28-32 DEG C, sonic oscillation
25min, taking-up, which is set in refrigerator, places 24 hours, filters, and discards filtrate, and filter residue takes out, sieving in the dry 4.5h of 40 DEG C of blowings,
Up to grape seed oil-Benexate Hydrochloride.
3. one kind is rich in grape seed oil traditional Chinese medicine extract composition, which is characterized in that it is made of the raw material of following proportion: Portugal
Grape seed oil-Benexate Hydrochloride 15.75-67.5g, ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g, Radix Astragali 550g,
Preparation method is as follows: taking ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g, 10 times of medicinal material weight ratio of Radix Astragali 550g addition is dense
Degree is the ethyl alcohol of 75%v/v, is impregnated 168 hours at 38 DEG C -40 DEG C, leaching soaked extracting solution, and recycling ethyl alcohol obtains leaching liquor guarantor
It deposits spare, the dregs of a decoction is separately pressed to 8 times of medicinal material weight, 5 times, 3 extraordinarily water boiling and extraction 3 times respectively, decocting extraction time is for the first time 2
Hour, second 1 hour, third time 0.5 hour, merging decocted extracting solution three times, filtered, be concentrated into specific gravity be 1.0 it is dense
When contracting liquid, then with the leaching liquor after above-mentioned recycling ethyl alcohol merge mixing, through it is dry to water content be 4-5%, obtain Chinese medical extract,
Grape seed oil-Benexate Hydrochloride is mixed with Chinese medical extract separately, is stirred evenly, sieving mentions to get grape seed oil Chinese medicine
Take compositions；Grape seed oil-the Benexate Hydrochloride is made by following methods: by grape seed oil: beta-cyclodextrin
Weight ratio is 1:4.5 ratio, weighs the aqueous solution that beta-cyclodextrin is configured to 4.5% by weight percentage, heating stirring make it is molten, to
Solution, which is cooled to room temperature, is added grape seed oil, is put into ultrasonic wave pond, under the conditions of temperature is 28-32 DEG C, sonic oscillation
25min, taking-up, which is set in refrigerator, places 24 hours, filters, and discards filtrate, and filter residue takes out, sieving in the dry 4.5h of 40 DEG C of blowings,
Up to grape seed oil-Benexate Hydrochloride.
4. routinely tablet, capsule, granule or wine product are made as preparation in technique to the composition as described in claim 1-3
The purposes of health care product.
5. purposes of the composition as the additive prepared in cosmetics as described in claim 1-3.
6. the purposes of composition according to claim 4, for preparing effervescent tablet, chewable tablets, buccal tablet.
7. the purposes of composition according to claim 4, for preparing white wine, grape wine, yellow rice wine and beer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811342113.4A CN109453270A (en) | 2018-11-12 | 2018-11-12 | Rich in grape seed oil traditional Chinese medicine extract composition and purposes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811342113.4A CN109453270A (en) | 2018-11-12 | 2018-11-12 | Rich in grape seed oil traditional Chinese medicine extract composition and purposes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109453270A true CN109453270A (en) | 2019-03-12 |
Family
ID=65610136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811342113.4A Withdrawn CN109453270A (en) | 2018-11-12 | 2018-11-12 | Rich in grape seed oil traditional Chinese medicine extract composition and purposes |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109453270A (en) |
-
2018
- 2018-11-12 CN CN201811342113.4A patent/CN109453270A/en not_active Withdrawn
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