CN109276590A - Composition and purposes rich in procyanidine and Chinese medical extract - Google Patents

Composition and purposes rich in procyanidine and Chinese medical extract Download PDF

Info

Publication number
CN109276590A
CN109276590A CN201811341537.9A CN201811341537A CN109276590A CN 109276590 A CN109276590 A CN 109276590A CN 201811341537 A CN201811341537 A CN 201811341537A CN 109276590 A CN109276590 A CN 109276590A
Authority
CN
China
Prior art keywords
procyanidine
composition
chinese medical
purposes
extract
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201811341537.9A
Other languages
Chinese (zh)
Inventor
张奎昌
张路
花丽
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pizhou Gas Star Pharmaceutical Technology Service Co Ltd
Original Assignee
Pizhou Gas Star Pharmaceutical Technology Service Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pizhou Gas Star Pharmaceutical Technology Service Co Ltd filed Critical Pizhou Gas Star Pharmaceutical Technology Service Co Ltd
Priority to CN201811341537.9A priority Critical patent/CN109276590A/en
Publication of CN109276590A publication Critical patent/CN109276590A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
    • C12G3/00—Preparation of other alcoholic beverages
    • C12G3/04—Preparation of other alcoholic beverages by mixing, e.g. for preparation of liqueurs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/10—General cosmetic use

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Organic Chemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention discloses one kind to be rich in procyanidine traditional Chinese medicine extract composition, and it is procyanidine-Benexate Hydrochloride 25-50% that it is by procyanidine-Benexate Hydrochloride and Chinese medical extract by weight percentage, and Chinese medical extract 50-75% is made.The present invention has beneficial effect that is anti-oxidant, removing free radical using procyanidine, and with benefiting qi and removing blood stasis, menstruation-regulating and speckle-dispelling, nourish the Chinese traditional medicine composition of skin effect, damage to prevention and treatment free radical to skin, promotes blood circulation, and promoting skin cell development has preferable assisting in preventing and treating effect.By the extract of procyanidine-Benexate Hydrochloride and Chinese traditional medicine composition of the present invention, new Pharmaceutical composition is formed, procyanidine and traditional Chinese medicine ingredients beneficial effect can be given full play to.Rich in procyanidine traditional Chinese medicine extract composition, routinely tablet, capsule, granule, oral solution or wine product are made as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics in technique to the present invention.

Description

Composition and purposes rich in procyanidine and Chinese medical extract
Technical field
The present invention relates to pharmaceutical preparation and/or health food manufacture fields, and in particular to a kind of to be pasted by procyanidine-β-ring The pharmaceutical composition and purposes of inclusion compounds and Chinese medical extract composition.
Background technique
Procyanidine (Procyanidins) is the poly- Polyphenols mixture being widely present in nature, mainly by catechin Monomer, dimer, tripolymer ..., ten aggressiveness are formed by combining.Glucosidase procyanidins (s), low toxicity efficient with it, high bioavailability are famous by OligomericProcyanidins, OPC '.OPC ' s possesses strong Oxidation resistance, it is 50 times of vitamin E that its is anti-oxidant in vivo, removes ability of free radical, ascorbic 20 times, and Absorption is complete rapidly, and highest blood concentration can be obtained in oral 20mg, and metabolic half life is about 7h.Foreign countries are about OPC ' s performance There are many research, and are used for food, beverage, cosmetics and field of health care products extensively.Nineteen ninety-five Mo, U.S. Whole Foods Magazine has held the poll for the botanical medicine trusted by public freedom vote by ballot oneself, the case where not setting drug candidate Under, 89.9% ballot paper concentrates on 10 kinds of botanical medicines under one's name, and procyanidins are considered as most by American public favor and wind Waste the botanical medicine in U.S. herbal medicine market.
Procyanidine (Procyanidins, PC) is the total of the major class polyphenolic substance being widely present in vegetable kingdom Claim.Originally system is attributed to condensed tannin or flavanol compound, with the raising of separation identification technology and to substance of this kind research and understanding Go deep into, the substance is classified as the big substance of relatively independent one and referred to as procyanidine.
Procyanidine physiological function shows themselves in that (1) antioxidant function, (2) anti-cancer function, and (3) remove free radical, polyphenol Class compound removes the activity of free radical mainly since they provide the reason of hydrogen atom, and in addition the delocalization of pi bond is imitated on phenyl ring The function that reply polyphenol compound removes free radical also has significant contribution.Sarma etc. investigated anthocyanin protect DNA not by The effect that hydroxyl radical free radical destroys, discovery anthocyanin can combine with DNA and form complex compound, can protect DNA but also protection Itself is not by the destruction of free radical.(4) application of the procyanidine in the fields such as drug and cosmetics, grape pip procyanidin Vasoactive, elastase inhibitor activity and antioxidant activity make it be used widely in the fields such as drug and cosmetics.
1. drug grape pip procyanidin is to the therapeutic value of vascular diseases in early 1980s i.e. by common people institute Recognize.In France, the patented product made of grape pip procyanidin is for treating microcirculatory disorders, including eyes and outer peritricha Thin vascular permeability disorder and vein and lymphatic function be not complete；The inventions such as French Bonnaure are with procyanidine oligomer or monomer To treat periodontosis preparation and patent has been obtained for active constituent (content 0.1%)；French Sanofi company grape pip procyanidin Compound (every contains this compound 250mg) is made with soybean lecithin, is used as Vasoprotectant and anti-inflammatory agent；French Vennat Deng the high dose piece (50mg/ piece) containing 80% procyanidine is also made, which can discharge rapidly and completely, and in different items Under part, storage still has good stability in 10 months；The Berkhman etc. of Germany has developed the original flower for treating alcoholism Green element preparation etc..
2. cosmetics nineteen ninety France Masquelier is for example anti-inflammatory, anti-to therapeutic effect of the procyanidine in idicatio Radiation isoreactivity is studied.The result shows that the therapeutic effect of procyanidine and the ability that it removes free radical are closely related, And the degenerative process of lipid, protein and nucleic acid caused by stimulation of the environment to skin, mucous membrane and hair needs not with free radical It can divide.Strength antioxygenic activity possessed by procyanidine and the ability for removing free radical are that it is making up as bioactive ingredients The basis of inherence used in product.
3. the application in food is due to OPC ' s from food raw material and production process is not introduced into nuisance substantially Matter, because its safety is unquestionable again, as antioxidant come using not having any problems in food.It is in food at present Come primarily as the hardening agent of natural, healthy food material and nourishing reinforced food using (Lian Fujihong is military Chief editor, " dietotherapeutic resource and bioactive ingredients ", Chemical Industry Press, September the 1st edition in 2005,189-191 pages).
Since modern people's rhythm of life is accelerated, life stress is big, the variation of life pattern, and environmental pollution is to the modern times in addition Increasing trend is also presented in some distinctive diseases accordingly in life.Such as because of insufficiency of vital energy and blood, the institutes such as qi and blood retardance or qi deficiency to blood stasis The endocrine disturbance of cause, chloasma (blackish facial patch), freckle, butterfly macules, the yellow cases such as coarse of skin surface obviously increase, until current There is not the therapeutic agent of definite curative effect yet.Have effects that special anti-oxidant and effect of scavenging radical using procyanidine, In conjunction with the traditional traditional Chinese medical theory in China, with benefiting qi and removing blood stasis, menstruation-regulating and speckle-dispelling nourishes the Chinese traditional medicine composition of skin, by former cyanine This natural active matter of element and traditional medicine and modern pharmaceutical technology organically combine, and form a kind of new pharmaceutical composition Object enables the composition to play the preventive and therapeutic effect of auxiliary in the treatment of above-mentioned disease.
Summary of the invention
The purpose of the present invention is to provide be by procyanidine-β-ring paste rich in procyanidine traditional Chinese medicine extract composition Inclusion compounds and Chinese medical extract composition.
The object of the invention is also to provide the compositions in preparation auxiliary adjustment benefiting qi and removing blood stasis, menstruation-regulating and speckle-dispelling, nourishes flesh As the purposes for preparing health care product in skin drug.
The object of the invention is also to provide the pharmaceutical compositions in the purposes for preparing the additive in cosmetics.
It is provided by the invention to be rich in procyanidine traditional Chinese medicine extract composition, which is characterized in that it is by procyanidine-β- Cyclodextrin inclusion compound and Chinese medical extract are procyanidine-Benexate Hydrochloride 25-50%, traditional Chinese medicine extraction by weight percentage Object 50-75% is made, and the Chinese medical extract is prepared as follows: yellow by ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g Stilbene 550g is added concentration and impregnates 168 hours at 38-42 DEG C for the ethyl alcohol 12500g of 75%(v/v), and leaching soaked extracting solution is returned Receipts ethyl alcohol obtains leaching liquor and saves backup, and the dregs of a decoction is separately added water to cook 3 times by 8 times, 5 times, 3 times of medicinal material weight respectively, decocting time Be the 1st time 2 hours, second 1 hour, third time 0.5 hour merged 3 decoction liquors, through filtering, it is concentrated to specific gravity be 1.0 Concentrate when, then merge with the leaching liquor after above-mentioned recycling ethyl alcohol, be further condensed into thick paste, it is dry to be less than to water content 5%w/w obtains Chinese medical extract, separately mixes procyanidine-Benexate Hydrochloride with Chinese medical extract, stirs evenly, sieving, Up to rich in procyanidine traditional Chinese medicine extract composition；Procyanidine-the Benexate Hydrochloride is made by following methods: In procyanidine: the weight ratio of beta-cyclodextrin is 1:10 ratio, in the dehydrated alcohol for first weighing 10 times of weight of procyanidine addition, Being placed in grinding in mortar makes molten, and beta-cyclodextrin is added and is mediated to form one uniform paste, grinding 35min is continued, in Dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get procyanidine-Benexate Hydrochloride.
The dry drying means using under the conditions of dry technology well known in the art described above, is such as dried in vacuo, is cold Dry or hot wind low temperature drying etc. is lyophilized, in the condition in view of avoiding or reducing the loss of effective component in Chinese medical extract, choosing Select the drying process for avoiding the drying means of high temperature suitable for the present invention.
Routinely tablet, capsule, granule, oral solution is made as the use for preparing health care product in technique to the composition On the way.
The composition is as the purposes for preparing wine product.
Purposes of the composition as the additive prepared in cosmetics.
Ginseng, sweet, slight bitter, tepor.Returns spleen, lung, heart kidney channel.It with replenish vital energy, restore pulse, and strengthen and remove vital energy, reinforces the spleen to benefit the lung, promotes the production of body fluid Blood-nourishing, tranquilize the mind and promote the intelligence function.Ginseng reinforces vital energy, and vigour is filled, and the motive must support, and the mind obtains rather, intelligence obtain it is clever, and have calm the nerves benefit The effect of intelligence, for treating deficiency of heart-QI or heart kidney qi deficiency, the insomnia of the insufficiency of heart and spleen, amnesia etc..Ginseng sweet temperature, reinforces vital energy, QI invigorating has the benefits of qi-blood tonifying with green blood, therefore can be used and control deficiency of spleen-QI and stomach-QI, changes source deficiency, the card of blood deficiency chlorosis.
Radix Angelicae Sinensis, sweet, acrid, warm.Return liver, the heart, the spleen channel.With replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels function is used for blood Empty sallow, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, intestinal dryness is just It is secret.The sweet temperature of Radix Angelicae Sinensis, blood-nourishing qi-restoratives, for good medicine of enriching blood, thus it is available control heart-liver blood deficiency, color is sallow, dizziness palpitaition.
Rhizome of chuanxiong, it is acrid in flavour and warm in nature.Return liver, gallbladder, pericardium channel.With blood-activating and qi-promoting, wind-expelling pain-stopping function.The pungent scattered temperature of rhizome of chuanxiong is logical, function Blood-activating and qi-promoting has the title of " gas medicine in blood " (" collected statements on the herbal foundation ").Both promoting blood circulation was promoted blood circulation, kind to control heart arteries and veins stasis blocking, chest impediment and cardialgia；Again Promote breath and open depression analgesic, the sternal rib shouting pain by stagnation of QI due to depression of the liver are multi-purpose.Rhizome of chuanxiong is good at " lower menstruation regulating water " (" collected statements on the herbal foundation "), promoting blood circulation is adjusted Through the excellent key medicine for cards such as irregular menstruation, dysmenorrhea, menostasis；Yi Zhi abdominal mass and abdominal pain, the function with promoting blood circulation, disease eliminating powder junction.
Radix Astragali, sweet, tepor.Return lung, the spleen channel.With tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, shengjin nourishing, row is stagnant to be led to Numbness, pus draining and toxin expelling, expelling pus and promoting granulation effect is out of strength for qi and blood, anorexia and loose stool, the sinking of qi of middle-jiao, diarrhea rectal prolapse, uterine bleeding of having blood in stool, table Empty spontaneous perspiration, deficiency of vital energy and edema, Heat Diabetes, the sallow card of the deficiency of vital energy.The sweet tepor of Radix Astragali, benefiting qi and raising yang, lid Yin grows while yang is generating, the prosperous blood of gas It is raw, therefore have the function of qi-supplementing, blood-engendering, long to be used for overstrain internal injury, gas loses the deficiency of blood, and deficiency of blood sun is floating, the hot flushing of flesh, the deficiency of blood of the big inability of arteries and veins Fever card.And worry beyond measure, internal lesion caused by overexertion heart spleen, deficiency of qi and blood, sallow complexion, palpitation and insomnia person.
Above 4 kinds of Chinese medicinal compositions prepare extract, prove there is benefiting qi and removing blood stasis according to traditional Chinese medical theory, menstruation-regulating and speckle-dispelling is grown Skin effect is supported, by modern Chinese herbal medicine theoretical research, if Radix Angelicae Sinensis is one of main ingredient in component, effective component ferulic acid be can be reduced H2O2Content, and inhibit oxidation reaction and radical reaction in conjunction with phosphatidyl-ethanolamine, damage of the antagonism free radical to tissue, It promotes blood circulation, promotes the effect of skin cell development.Free radical can not only be quenched in ferulic acid.But also it is raw to be adjustable human body Reason mechanism inhibits the enzyme generated free radicals, promotes the generation for removing the enzyme of free radical.
Heterogeneity, no can be generated using procyanidine-Benexate Hydrochloride active constituent and Chinese traditional medicine composition extract The synergistic therapeutic action of same-action mechanism can strengthen the anti-oxidant and effect of scavenging radical of its drug.The present invention utilizes former flower Green element has beneficial effect that is anti-oxidant, removing free radical, and with benefiting qi and removing blood stasis, menstruation-regulating and speckle-dispelling is nourished in skin effect Medicine combination, the damage to prevention and treatment free radical to skin, promotes blood circulation, and promoting skin cell development has preferable auxiliary anti- Control effect.By the extract of procyanidine-Benexate Hydrochloride and Chinese traditional medicine composition of the present invention, new pharmaceutical compositions are formed Object can give full play to procyanidine and traditional Chinese medicine ingredients beneficial effect, especially increase the special antioxygen that procyanidine has The effect of changing and removing free radical enhances drug to skin injury, spot, tinea disease and cutaneous pigmentation etc. with good The application that conditioning functions are pharmaceutical composition of the present invention in health food, cosmetics provides theoretical basis.Especially antioxygen Change, remove free radical and physical function conditioning functions are more significant, thus product both can be used as health food it is for oral administration edible or It drinks, also can be used as natural beauty skin care product external application.The present invention overcomes current Chinese traditional medicine composition component and effect is undesirable Problem, and product is easy to use, good in taste, simple process, high production efficiency, quality are stablized, can be widely used for health care product, The production of wine product, cosmetics.
Of the invention is rich in anthocyanidin traditional Chinese medicine extract composition, can according to need and is configured to different peroral dosage forms. Pharmaceutical composition and pharmaceutically acceptable auxiliary material can be hybridly prepared into tablet, capsule, granule, wine product etc., Middle capsule can be prepared into soft capsule and hard capsule；The wherein preferred effervescent tablet of tablet, chewable tablets, buccal tablet, because of effervesce Piece, chewable tablets, buccal tablet have following advantage compared with conventional tablet: (1) convenient to take, chewable clothes, buccal, Ke Huashui, A certain amount of sugared part will be added as excipient due to preparing these tablets, thus it is in good taste, and people gladly take, effervescent tablet Add after water self-dissolving like one glass of beverage, people is made to be happy to drink；(2) absorb it is fast because direct oral cavity or bubble drink make drug ingedient from Sonization is allowed to absorb fast, bioavilability height；(3) easy to carry, convenient transportation；Wherein the wine product can be made into white wine, Portugal Grape wine, yellow rice wine and beer product.A kind of Pharmaceutical composition of the present invention, can also be configured to cosmetics as needed.
Specific embodiment
It is that the present invention is further illustrated, but does not constitute any limit to the scope of the present invention by following embodiment System.
Embodiment 1
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is 75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.5% to get Chinese medical extract；Weigh original Anthocyanidin-Benexate Hydrochloride 25g is mixed with Chinese medical extract 75g, is stirred evenly, and sieving is to get rich in procyanidine Medicament extract composition；Procyanidine-the Benexate Hydrochloride is made by following methods: being weighed procyanidine 2.5g and is added Entering into 10g dehydrated alcohol to be placed in mortar grinding makes molten, and beta-cyclodextrin 25g is added and is mediated to form a uniform paste Agent continues to grind 35min, and dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get former cyanine Element-Benexate Hydrochloride.
It is described rich in procyanidine traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 2
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is 75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.8% to get Chinese medical extract；Weigh original Anthocyanidin-Benexate Hydrochloride 50g is mixed with Chinese medical extract 50g, is stirred evenly, and sieving is to get rich in procyanidine Medicament extract composition；Procyanidine-the Benexate Hydrochloride is made by following methods: weighing procyanidine 5g addition Grinding is placed in mortar into 50g dehydrated alcohol to be made molten, and beta-cyclodextrin 50g is added and is mediated to form a uniform paste Agent continues to grind 35min, and dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get former cyanine Element-Benexate Hydrochloride.
It is described rich in procyanidine traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 3
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is 75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.2% to get Chinese medical extract；Weigh original Anthocyanidin-Benexate Hydrochloride 40g is mixed with Chinese medical extract 60g, is stirred evenly, and sieving is to get rich in procyanidine Medicament extract composition；Procyanidine-the Benexate Hydrochloride is made by following methods: weighing procyanidine 4g addition Grinding is placed in mortar into 40g dehydrated alcohol to be made molten, and beta-cyclodextrin 40g is added and is mediated to form a uniform paste Agent continues to grind 35min, and dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get former cyanine Element-Benexate Hydrochloride.
It is described rich in procyanidine traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 4
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is 75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.6% to get Chinese medical extract；Weigh original Anthocyanidin-Benexate Hydrochloride 35g is mixed with Chinese medical extract 65g, is stirred evenly, and sieving is to get rich in procyanidine Medicament extract composition；Procyanidine-the Benexate Hydrochloride is made by following methods: being weighed procyanidine 3.5g and is added Entering into 35g dehydrated alcohol to be placed in mortar grinding makes molten, and beta-cyclodextrin 35g is added and is mediated to form a uniform paste Agent continues to grind 35min, and dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get former cyanine Element-Benexate Hydrochloride.
It is described rich in procyanidine traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 5
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is 75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.5% to get Chinese medical extract；Weigh original Anthocyanidin-Benexate Hydrochloride 30g is mixed with Chinese medical extract 70g, is stirred evenly, and sieving is to get rich in procyanidine Medicament extract composition；Procyanidine-the Benexate Hydrochloride is made by following methods: weighing procyanidine 3g addition Grinding is placed in mortar into 30g dehydrated alcohol to be made molten, and beta-cyclodextrin 30g is added and is mediated to form a uniform paste Agent continues to grind 35min, and dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get former cyanine Element-Benexate Hydrochloride.
It is described rich in procyanidine traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 6
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is 75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution；After alcohol is extracted The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.7% to get Chinese medical extract；Weigh original Anthocyanidin-Benexate Hydrochloride 45g is mixed with Chinese medical extract 55g, is stirred evenly, and sieving is to get rich in procyanidine Medicament extract composition；Procyanidine-the Benexate Hydrochloride is made by following methods: being weighed procyanidine 4.5g and is added Entering into 45g dehydrated alcohol to be placed in mortar grinding makes molten, and beta-cyclodextrin 45g is added and is mediated to form a uniform paste Agent continues to grind 35min, and dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get former cyanine Element-Benexate Hydrochloride.
It is described rich in procyanidine traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.

Claims (5)

1. one kind is rich in procyanidine traditional Chinese medicine extract composition, which is characterized in that it is by procyanidine-beta-cyclodextrin inclusion compound Object and Chinese medical extract are procyanidine-Benexate Hydrochloride 25-50%, Chinese medical extract 50-75% by weight percentage Be made, preparation method: procyanidine-Benexate Hydrochloride being mixed with Chinese medical extract, is stirred evenly, sieving to get Rich in procyanidine traditional Chinese medicine extract composition；The Chinese medical extract is prepared as follows: by ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g, Radix Astragali 550g are added the ethyl alcohol 12500g that concentration is 75%v/v and impregnate 168 hours at 38-42 DEG C, filter Soaked extracting solution is taken, recycling ethyl alcohol obtains leaching liquor and saves backup, and the dregs of a decoction are separately pressed to 8 times of medicinal material weight, 5 times, 3 extraordinarily decoctings respectively It boils 3 times, decocting time is the 1st time 2 hours, and second 1 hour, third time 0.5 hour merged 3 decoction liquors, filtered, and is passed through When being concentrated into the concentrate that specific gravity is 1.0, then merge with the leaching liquor after above-mentioned recycling ethyl alcohol, be further condensed into thick paste, It is dry to obtain Chinese medical extract less than 5%w/w to water content；Procyanidine-the Benexate Hydrochloride is by following methods system : in procyanidine: the weight ratio of beta-cyclodextrin is 1:10 ratio, first weighs the dehydrated alcohol that procyanidine is added 10 times of weight In, being placed in grinding in mortar makes molten, and beta-cyclodextrin is added and is mediated to form one uniform paste, grinding 35min is continued, Dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get procyanidine-Benexate Hydrochloride.
2. routinely tablet, capsule, granule, oral solution or wine product are made in technique to composition according to claim 1 Purposes.
3. purposes of the composition according to claim 1 as the additive prepared in cosmetics.
4. the purposes of composition according to claim 2, for preparing effervescent tablet, chewable tablets, buccal tablet.
5. the purposes of composition according to claim 2, for being configured to white wine, grape wine, yellow rice wine and beer.
CN201811341537.9A 2018-11-12 2018-11-12 Composition and purposes rich in procyanidine and Chinese medical extract Withdrawn CN109276590A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811341537.9A CN109276590A (en) 2018-11-12 2018-11-12 Composition and purposes rich in procyanidine and Chinese medical extract

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811341537.9A CN109276590A (en) 2018-11-12 2018-11-12 Composition and purposes rich in procyanidine and Chinese medical extract

Publications (1)

Publication Number Publication Date
CN109276590A true CN109276590A (en) 2019-01-29

Family

ID=65175486

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201811341537.9A Withdrawn CN109276590A (en) 2018-11-12 2018-11-12 Composition and purposes rich in procyanidine and Chinese medical extract

Country Status (1)

Country Link
CN (1) CN109276590A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110959735A (en) * 2019-12-17 2020-04-07 天津市尖峰天然产物研究开发有限公司 Candy added with vaccinium myrtillus extract and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110959735A (en) * 2019-12-17 2020-04-07 天津市尖峰天然产物研究开发有限公司 Candy added with vaccinium myrtillus extract and preparation method thereof

Similar Documents

Publication Publication Date Title
CN102895410A (en) Health-strengthening donkey-hide gelatin jelly for females
CN106176515A (en) A kind of body whitening crème and preparation method thereof
CN109223908A (en) Composition and purposes rich in green-tea extract and Chinese medical extract
CN109276590A (en) Composition and purposes rich in procyanidine and Chinese medical extract
CN109260320A (en) A kind of composition and purposes of tea polyphenols and Chinese medical extract
CN109453266A (en) A kind of composition and purposes of green-tea extract and Chinese medical extract
CN103830558B (en) Anti-aging composition and preparation method thereof
CN102133167A (en) Freckle removing facial mask made of traditional Chinese medicine and preparation process thereof
CN104940725A (en) Dendrobium officinale traditional Chinese medicinal composition for nourishing blood and beautifying and preparation thereof
CN108815015A (en) A kind of eye mask and its production technology
CN109453225A (en) One kind being rich in vitamin C traditional Chinese medicine extract composition and purposes
CN109364113A (en) A kind of composition and purposes of resveratrol and Chinese medical extract
CN103734425B (en) A kind of leaves of Hawthorn hypoglycemic health protection tea and preparation method thereof
CN109453227A (en) A kind of composition and purposes of procyanidine and Chinese medical extract
CN109223855A (en) One kind being rich in vitamin E traditional Chinese medicine extract composition and purposes
CN106344480A (en) Whitening and freckle-removing traditional Chinese medicine facial mask without toxic or side effect, and preparation method of traditional Chinese medicine facial mask
CN109331089A (en) Composition and purposes rich in tea polyphenols Chinese medical extract
CN105687522A (en) Pharmaceutical composition with chloasma removing function and preparation method thereof
KR20040081248A (en) Preparation method of functional bath material containing Curcuma longa L.
CN105055856B (en) A kind of Tea Pigment Chinese medicine composition and its preparation method and application for treating cardiovascular and cerebrovascular disease
CN108714176A (en) It is a kind of to treat Chinese medicine with grey hair
CN108378308A (en) A kind of deer blood double color plate health food and preparation method thereof
CN102715508B (en) Compound walnut soft shell capsule enhanced nourishment
CN107496699A (en) The external medicine composition and its preparation and application of a kind of beautifying face and moistering lotion
CN108379515B (en) Medicine with angina pectoris treating effect and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication
WW01 Invention patent application withdrawn after publication

Application publication date: 20190129