CN109276590A - Composition and purposes rich in procyanidine and Chinese medical extract - Google Patents
Composition and purposes rich in procyanidine and Chinese medical extract Download PDFInfo
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- CN109276590A CN109276590A CN201811341537.9A CN201811341537A CN109276590A CN 109276590 A CN109276590 A CN 109276590A CN 201811341537 A CN201811341537 A CN 201811341537A CN 109276590 A CN109276590 A CN 109276590A
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- procyanidine
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- chinese medical
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- extract
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Abstract
The invention discloses one kind to be rich in procyanidine traditional Chinese medicine extract composition, and it is procyanidine-Benexate Hydrochloride 25-50% that it is by procyanidine-Benexate Hydrochloride and Chinese medical extract by weight percentage, and Chinese medical extract 50-75% is made.The present invention has beneficial effect that is anti-oxidant, removing free radical using procyanidine, and with benefiting qi and removing blood stasis, menstruation-regulating and speckle-dispelling, nourish the Chinese traditional medicine composition of skin effect, damage to prevention and treatment free radical to skin, promotes blood circulation, and promoting skin cell development has preferable assisting in preventing and treating effect.By the extract of procyanidine-Benexate Hydrochloride and Chinese traditional medicine composition of the present invention, new Pharmaceutical composition is formed, procyanidine and traditional Chinese medicine ingredients beneficial effect can be given full play to.Rich in procyanidine traditional Chinese medicine extract composition, routinely tablet, capsule, granule, oral solution or wine product are made as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics in technique to the present invention.
Description
Technical field
The present invention relates to pharmaceutical preparation and/or health food manufacture fields, and in particular to a kind of to be pasted by procyanidine-β-ring
The pharmaceutical composition and purposes of inclusion compounds and Chinese medical extract composition.
Background technique
Procyanidine (Procyanidins) is the poly- Polyphenols mixture being widely present in nature, mainly by catechin
Monomer, dimer, tripolymer ..., ten aggressiveness are formed by combining.Glucosidase procyanidins
(s), low toxicity efficient with it, high bioavailability are famous by OligomericProcyanidins, OPC '.OPC ' s possesses strong
Oxidation resistance, it is 50 times of vitamin E that its is anti-oxidant in vivo, removes ability of free radical, ascorbic 20 times, and
Absorption is complete rapidly, and highest blood concentration can be obtained in oral 20mg, and metabolic half life is about 7h.Foreign countries are about OPC ' s performance
There are many research, and are used for food, beverage, cosmetics and field of health care products extensively.Nineteen ninety-five Mo, U.S. Whole Foods
Magazine has held the poll for the botanical medicine trusted by public freedom vote by ballot oneself, the case where not setting drug candidate
Under, 89.9% ballot paper concentrates on 10 kinds of botanical medicines under one's name, and procyanidins are considered as most by American public favor and wind
Waste the botanical medicine in U.S. herbal medicine market.
Procyanidine (Procyanidins, PC) is the total of the major class polyphenolic substance being widely present in vegetable kingdom
Claim.Originally system is attributed to condensed tannin or flavanol compound, with the raising of separation identification technology and to substance of this kind research and understanding
Go deep into, the substance is classified as the big substance of relatively independent one and referred to as procyanidine.
Procyanidine physiological function shows themselves in that (1) antioxidant function, (2) anti-cancer function, and (3) remove free radical, polyphenol
Class compound removes the activity of free radical mainly since they provide the reason of hydrogen atom, and in addition the delocalization of pi bond is imitated on phenyl ring
The function that reply polyphenol compound removes free radical also has significant contribution.Sarma etc. investigated anthocyanin protect DNA not by
The effect that hydroxyl radical free radical destroys, discovery anthocyanin can combine with DNA and form complex compound, can protect DNA but also protection
Itself is not by the destruction of free radical.(4) application of the procyanidine in the fields such as drug and cosmetics, grape pip procyanidin
Vasoactive, elastase inhibitor activity and antioxidant activity make it be used widely in the fields such as drug and cosmetics.
1. drug grape pip procyanidin is to the therapeutic value of vascular diseases in early 1980s i.e. by common people institute
Recognize.In France, the patented product made of grape pip procyanidin is for treating microcirculatory disorders, including eyes and outer peritricha
Thin vascular permeability disorder and vein and lymphatic function be not complete;The inventions such as French Bonnaure are with procyanidine oligomer or monomer
To treat periodontosis preparation and patent has been obtained for active constituent (content 0.1%);French Sanofi company grape pip procyanidin
Compound (every contains this compound 250mg) is made with soybean lecithin, is used as Vasoprotectant and anti-inflammatory agent;French Vennat
Deng the high dose piece (50mg/ piece) containing 80% procyanidine is also made, which can discharge rapidly and completely, and in different items
Under part, storage still has good stability in 10 months;The Berkhman etc. of Germany has developed the original flower for treating alcoholism
Green element preparation etc..
2. cosmetics nineteen ninety France Masquelier is for example anti-inflammatory, anti-to therapeutic effect of the procyanidine in idicatio
Radiation isoreactivity is studied.The result shows that the therapeutic effect of procyanidine and the ability that it removes free radical are closely related,
And the degenerative process of lipid, protein and nucleic acid caused by stimulation of the environment to skin, mucous membrane and hair needs not with free radical
It can divide.Strength antioxygenic activity possessed by procyanidine and the ability for removing free radical are that it is making up as bioactive ingredients
The basis of inherence used in product.
3. the application in food is due to OPC ' s from food raw material and production process is not introduced into nuisance substantially
Matter, because its safety is unquestionable again, as antioxidant come using not having any problems in food.It is in food at present
Come primarily as the hardening agent of natural, healthy food material and nourishing reinforced food using (Lian Fujihong is military
Chief editor, " dietotherapeutic resource and bioactive ingredients ", Chemical Industry Press, September the 1st edition in 2005,189-191 pages).
Since modern people's rhythm of life is accelerated, life stress is big, the variation of life pattern, and environmental pollution is to the modern times in addition
Increasing trend is also presented in some distinctive diseases accordingly in life.Such as because of insufficiency of vital energy and blood, the institutes such as qi and blood retardance or qi deficiency to blood stasis
The endocrine disturbance of cause, chloasma (blackish facial patch), freckle, butterfly macules, the yellow cases such as coarse of skin surface obviously increase, until current
There is not the therapeutic agent of definite curative effect yet.Have effects that special anti-oxidant and effect of scavenging radical using procyanidine,
In conjunction with the traditional traditional Chinese medical theory in China, with benefiting qi and removing blood stasis, menstruation-regulating and speckle-dispelling nourishes the Chinese traditional medicine composition of skin, by former cyanine
This natural active matter of element and traditional medicine and modern pharmaceutical technology organically combine, and form a kind of new pharmaceutical composition
Object enables the composition to play the preventive and therapeutic effect of auxiliary in the treatment of above-mentioned disease.
Summary of the invention
The purpose of the present invention is to provide be by procyanidine-β-ring paste rich in procyanidine traditional Chinese medicine extract composition
Inclusion compounds and Chinese medical extract composition.
The object of the invention is also to provide the compositions in preparation auxiliary adjustment benefiting qi and removing blood stasis, menstruation-regulating and speckle-dispelling, nourishes flesh
As the purposes for preparing health care product in skin drug.
The object of the invention is also to provide the pharmaceutical compositions in the purposes for preparing the additive in cosmetics.
It is provided by the invention to be rich in procyanidine traditional Chinese medicine extract composition, which is characterized in that it is by procyanidine-β-
Cyclodextrin inclusion compound and Chinese medical extract are procyanidine-Benexate Hydrochloride 25-50%, traditional Chinese medicine extraction by weight percentage
Object 50-75% is made, and the Chinese medical extract is prepared as follows: yellow by ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g
Stilbene 550g is added concentration and impregnates 168 hours at 38-42 DEG C for the ethyl alcohol 12500g of 75%(v/v), and leaching soaked extracting solution is returned
Receipts ethyl alcohol obtains leaching liquor and saves backup, and the dregs of a decoction is separately added water to cook 3 times by 8 times, 5 times, 3 times of medicinal material weight respectively, decocting time
Be the 1st time 2 hours, second 1 hour, third time 0.5 hour merged 3 decoction liquors, through filtering, it is concentrated to specific gravity be 1.0
Concentrate when, then merge with the leaching liquor after above-mentioned recycling ethyl alcohol, be further condensed into thick paste, it is dry to be less than to water content
5%w/w obtains Chinese medical extract, separately mixes procyanidine-Benexate Hydrochloride with Chinese medical extract, stirs evenly, sieving,
Up to rich in procyanidine traditional Chinese medicine extract composition;Procyanidine-the Benexate Hydrochloride is made by following methods:
In procyanidine: the weight ratio of beta-cyclodextrin is 1:10 ratio, in the dehydrated alcohol for first weighing 10 times of weight of procyanidine addition,
Being placed in grinding in mortar makes molten, and beta-cyclodextrin is added and is mediated to form one uniform paste, grinding 35min is continued, in
Dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get procyanidine-Benexate Hydrochloride.
The dry drying means using under the conditions of dry technology well known in the art described above, is such as dried in vacuo, is cold
Dry or hot wind low temperature drying etc. is lyophilized, in the condition in view of avoiding or reducing the loss of effective component in Chinese medical extract, choosing
Select the drying process for avoiding the drying means of high temperature suitable for the present invention.
Routinely tablet, capsule, granule, oral solution is made as the use for preparing health care product in technique to the composition
On the way.
The composition is as the purposes for preparing wine product.
Purposes of the composition as the additive prepared in cosmetics.
Ginseng, sweet, slight bitter, tepor.Returns spleen, lung, heart kidney channel.It with replenish vital energy, restore pulse, and strengthen and remove vital energy, reinforces the spleen to benefit the lung, promotes the production of body fluid
Blood-nourishing, tranquilize the mind and promote the intelligence function.Ginseng reinforces vital energy, and vigour is filled, and the motive must support, and the mind obtains rather, intelligence obtain it is clever, and have calm the nerves benefit
The effect of intelligence, for treating deficiency of heart-QI or heart kidney qi deficiency, the insomnia of the insufficiency of heart and spleen, amnesia etc..Ginseng sweet temperature, reinforces vital energy,
QI invigorating has the benefits of qi-blood tonifying with green blood, therefore can be used and control deficiency of spleen-QI and stomach-QI, changes source deficiency, the card of blood deficiency chlorosis.
Radix Angelicae Sinensis, sweet, acrid, warm.Return liver, the heart, the spleen channel.With replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels function is used for blood
Empty sallow, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, ulcer sores, intestinal dryness is just
It is secret.The sweet temperature of Radix Angelicae Sinensis, blood-nourishing qi-restoratives, for good medicine of enriching blood, thus it is available control heart-liver blood deficiency, color is sallow, dizziness palpitaition.
Rhizome of chuanxiong, it is acrid in flavour and warm in nature.Return liver, gallbladder, pericardium channel.With blood-activating and qi-promoting, wind-expelling pain-stopping function.The pungent scattered temperature of rhizome of chuanxiong is logical, function
Blood-activating and qi-promoting has the title of " gas medicine in blood " (" collected statements on the herbal foundation ").Both promoting blood circulation was promoted blood circulation, kind to control heart arteries and veins stasis blocking, chest impediment and cardialgia;Again
Promote breath and open depression analgesic, the sternal rib shouting pain by stagnation of QI due to depression of the liver are multi-purpose.Rhizome of chuanxiong is good at " lower menstruation regulating water " (" collected statements on the herbal foundation "), promoting blood circulation is adjusted
Through the excellent key medicine for cards such as irregular menstruation, dysmenorrhea, menostasis;Yi Zhi abdominal mass and abdominal pain, the function with promoting blood circulation, disease eliminating powder junction.
Radix Astragali, sweet, tepor.Return lung, the spleen channel.With tonifying Qi and lifting yang, strengthening exterior and reducing sweat, inducing diuresis for removing edema, shengjin nourishing, row is stagnant to be led to
Numbness, pus draining and toxin expelling, expelling pus and promoting granulation effect is out of strength for qi and blood, anorexia and loose stool, the sinking of qi of middle-jiao, diarrhea rectal prolapse, uterine bleeding of having blood in stool, table
Empty spontaneous perspiration, deficiency of vital energy and edema, Heat Diabetes, the sallow card of the deficiency of vital energy.The sweet tepor of Radix Astragali, benefiting qi and raising yang, lid Yin grows while yang is generating, the prosperous blood of gas
It is raw, therefore have the function of qi-supplementing, blood-engendering, long to be used for overstrain internal injury, gas loses the deficiency of blood, and deficiency of blood sun is floating, the hot flushing of flesh, the deficiency of blood of the big inability of arteries and veins
Fever card.And worry beyond measure, internal lesion caused by overexertion heart spleen, deficiency of qi and blood, sallow complexion, palpitation and insomnia person.
Above 4 kinds of Chinese medicinal compositions prepare extract, prove there is benefiting qi and removing blood stasis according to traditional Chinese medical theory, menstruation-regulating and speckle-dispelling is grown
Skin effect is supported, by modern Chinese herbal medicine theoretical research, if Radix Angelicae Sinensis is one of main ingredient in component, effective component ferulic acid be can be reduced
H2O2Content, and inhibit oxidation reaction and radical reaction in conjunction with phosphatidyl-ethanolamine, damage of the antagonism free radical to tissue,
It promotes blood circulation, promotes the effect of skin cell development.Free radical can not only be quenched in ferulic acid.But also it is raw to be adjustable human body
Reason mechanism inhibits the enzyme generated free radicals, promotes the generation for removing the enzyme of free radical.
Heterogeneity, no can be generated using procyanidine-Benexate Hydrochloride active constituent and Chinese traditional medicine composition extract
The synergistic therapeutic action of same-action mechanism can strengthen the anti-oxidant and effect of scavenging radical of its drug.The present invention utilizes former flower
Green element has beneficial effect that is anti-oxidant, removing free radical, and with benefiting qi and removing blood stasis, menstruation-regulating and speckle-dispelling is nourished in skin effect
Medicine combination, the damage to prevention and treatment free radical to skin, promotes blood circulation, and promoting skin cell development has preferable auxiliary anti-
Control effect.By the extract of procyanidine-Benexate Hydrochloride and Chinese traditional medicine composition of the present invention, new pharmaceutical compositions are formed
Object can give full play to procyanidine and traditional Chinese medicine ingredients beneficial effect, especially increase the special antioxygen that procyanidine has
The effect of changing and removing free radical enhances drug to skin injury, spot, tinea disease and cutaneous pigmentation etc. with good
The application that conditioning functions are pharmaceutical composition of the present invention in health food, cosmetics provides theoretical basis.Especially antioxygen
Change, remove free radical and physical function conditioning functions are more significant, thus product both can be used as health food it is for oral administration edible or
It drinks, also can be used as natural beauty skin care product external application.The present invention overcomes current Chinese traditional medicine composition component and effect is undesirable
Problem, and product is easy to use, good in taste, simple process, high production efficiency, quality are stablized, can be widely used for health care product,
The production of wine product, cosmetics.
Of the invention is rich in anthocyanidin traditional Chinese medicine extract composition, can according to need and is configured to different peroral dosage forms.
Pharmaceutical composition and pharmaceutically acceptable auxiliary material can be hybridly prepared into tablet, capsule, granule, wine product etc.,
Middle capsule can be prepared into soft capsule and hard capsule;The wherein preferred effervescent tablet of tablet, chewable tablets, buccal tablet, because of effervesce
Piece, chewable tablets, buccal tablet have following advantage compared with conventional tablet: (1) convenient to take, chewable clothes, buccal, Ke Huashui,
A certain amount of sugared part will be added as excipient due to preparing these tablets, thus it is in good taste, and people gladly take, effervescent tablet
Add after water self-dissolving like one glass of beverage, people is made to be happy to drink;(2) absorb it is fast because direct oral cavity or bubble drink make drug ingedient from
Sonization is allowed to absorb fast, bioavilability height;(3) easy to carry, convenient transportation;Wherein the wine product can be made into white wine, Portugal
Grape wine, yellow rice wine and beer product.A kind of Pharmaceutical composition of the present invention, can also be configured to cosmetics as needed.
Specific embodiment
It is that the present invention is further illustrated, but does not constitute any limit to the scope of the present invention by following embodiment
System.
Embodiment 1
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution;After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.5% to get Chinese medical extract;Weigh original
Anthocyanidin-Benexate Hydrochloride 25g is mixed with Chinese medical extract 75g, is stirred evenly, and sieving is to get rich in procyanidine
Medicament extract composition;Procyanidine-the Benexate Hydrochloride is made by following methods: being weighed procyanidine 2.5g and is added
Entering into 10g dehydrated alcohol to be placed in mortar grinding makes molten, and beta-cyclodextrin 25g is added and is mediated to form a uniform paste
Agent continues to grind 35min, and dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get former cyanine
Element-Benexate Hydrochloride.
It is described rich in procyanidine traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 2
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution;After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.8% to get Chinese medical extract;Weigh original
Anthocyanidin-Benexate Hydrochloride 50g is mixed with Chinese medical extract 50g, is stirred evenly, and sieving is to get rich in procyanidine
Medicament extract composition;Procyanidine-the Benexate Hydrochloride is made by following methods: weighing procyanidine 5g addition
Grinding is placed in mortar into 50g dehydrated alcohol to be made molten, and beta-cyclodextrin 50g is added and is mediated to form a uniform paste
Agent continues to grind 35min, and dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get former cyanine
Element-Benexate Hydrochloride.
It is described rich in procyanidine traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 3
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution;After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.2% to get Chinese medical extract;Weigh original
Anthocyanidin-Benexate Hydrochloride 40g is mixed with Chinese medical extract 60g, is stirred evenly, and sieving is to get rich in procyanidine
Medicament extract composition;Procyanidine-the Benexate Hydrochloride is made by following methods: weighing procyanidine 4g addition
Grinding is placed in mortar into 40g dehydrated alcohol to be made molten, and beta-cyclodextrin 40g is added and is mediated to form a uniform paste
Agent continues to grind 35min, and dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get former cyanine
Element-Benexate Hydrochloride.
It is described rich in procyanidine traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 4
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution;After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.6% to get Chinese medical extract;Weigh original
Anthocyanidin-Benexate Hydrochloride 35g is mixed with Chinese medical extract 65g, is stirred evenly, and sieving is to get rich in procyanidine
Medicament extract composition;Procyanidine-the Benexate Hydrochloride is made by following methods: being weighed procyanidine 3.5g and is added
Entering into 35g dehydrated alcohol to be placed in mortar grinding makes molten, and beta-cyclodextrin 35g is added and is mediated to form a uniform paste
Agent continues to grind 35min, and dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get former cyanine
Element-Benexate Hydrochloride.
It is described rich in procyanidine traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 5
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution;After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.5% to get Chinese medical extract;Weigh original
Anthocyanidin-Benexate Hydrochloride 30g is mixed with Chinese medical extract 70g, is stirred evenly, and sieving is to get rich in procyanidine
Medicament extract composition;Procyanidine-the Benexate Hydrochloride is made by following methods: weighing procyanidine 3g addition
Grinding is placed in mortar into 30g dehydrated alcohol to be made molten, and beta-cyclodextrin 30g is added and is mediated to form a uniform paste
Agent continues to grind 35min, and dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get former cyanine
Element-Benexate Hydrochloride.
It is described rich in procyanidine traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Embodiment 6
Net medicinal material ginseng 150g, Radix Angelicae Sinensis 450g, rhizome of chuanxiong 100g are weighed respectively, and Radix Astragali 550g is placed in extractor, and concentration is added and is
75% ethyl alcohol 12.5kg, it is closed under the conditions of 40 DEG C to impregnate 168 hours, it was stirred 1 time, soaks every 6 hours during immersion
After bubble, soaked extracting solution recycling ethyl alcohol is obtained the another device of leaching liquor and saved backup by leaching soaked extracting solution;After alcohol is extracted
The dregs of a decoction are added 10 kilograms of pure water, and heating decocts 2 hours, leaching decoction liquor, and the dregs of a decoction add 6.25 kilograms of pure water, and heating is decocted
It boils 1 hour, leaching decoction liquor, then the dregs of a decoction is added 3.75 kilograms of pure water, heating decocts 0.5 hour, leaching decoction liquor, by 3 times
Decoction liquor merges, filtering, when concentrating the filtrate to the concentrate that specific gravity is 1.0, then merges with above-mentioned leaching liquor, further dense
After shortening thick paste into, being placed in vacuum drier and be dried under vacuum to water content is 4.7% to get Chinese medical extract;Weigh original
Anthocyanidin-Benexate Hydrochloride 45g is mixed with Chinese medical extract 55g, is stirred evenly, and sieving is to get rich in procyanidine
Medicament extract composition;Procyanidine-the Benexate Hydrochloride is made by following methods: being weighed procyanidine 4.5g and is added
Entering into 45g dehydrated alcohol to be placed in mortar grinding makes molten, and beta-cyclodextrin 45g is added and is mediated to form a uniform paste
Agent continues to grind 35min, and dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get former cyanine
Element-Benexate Hydrochloride.
It is described rich in procyanidine traditional Chinese medicine extract composition routinely technique be made tablet, capsule, granule or
Wine product are as the purposes for preparing health care product or as the purposes of the additive prepared in cosmetics.
Claims (5)
1. one kind is rich in procyanidine traditional Chinese medicine extract composition, which is characterized in that it is by procyanidine-beta-cyclodextrin inclusion compound
Object and Chinese medical extract are procyanidine-Benexate Hydrochloride 25-50%, Chinese medical extract 50-75% by weight percentage
Be made, preparation method: procyanidine-Benexate Hydrochloride being mixed with Chinese medical extract, is stirred evenly, sieving to get
Rich in procyanidine traditional Chinese medicine extract composition;The Chinese medical extract is prepared as follows: by ginseng 150g, Radix Angelicae Sinensis
450g, rhizome of chuanxiong 100g, Radix Astragali 550g are added the ethyl alcohol 12500g that concentration is 75%v/v and impregnate 168 hours at 38-42 DEG C, filter
Soaked extracting solution is taken, recycling ethyl alcohol obtains leaching liquor and saves backup, and the dregs of a decoction are separately pressed to 8 times of medicinal material weight, 5 times, 3 extraordinarily decoctings respectively
It boils 3 times, decocting time is the 1st time 2 hours, and second 1 hour, third time 0.5 hour merged 3 decoction liquors, filtered, and is passed through
When being concentrated into the concentrate that specific gravity is 1.0, then merge with the leaching liquor after above-mentioned recycling ethyl alcohol, be further condensed into thick paste,
It is dry to obtain Chinese medical extract less than 5%w/w to water content;Procyanidine-the Benexate Hydrochloride is by following methods system
: in procyanidine: the weight ratio of beta-cyclodextrin is 1:10 ratio, first weighs the dehydrated alcohol that procyanidine is added 10 times of weight
In, being placed in grinding in mortar makes molten, and beta-cyclodextrin is added and is mediated to form one uniform paste, grinding 35min is continued,
Dry under the conditions of 45 DEG C, gained dried object is ground with pestle, crosses 150 μm of sieves to get procyanidine-Benexate Hydrochloride.
2. routinely tablet, capsule, granule, oral solution or wine product are made in technique to composition according to claim 1
Purposes.
3. purposes of the composition according to claim 1 as the additive prepared in cosmetics.
4. the purposes of composition according to claim 2, for preparing effervescent tablet, chewable tablets, buccal tablet.
5. the purposes of composition according to claim 2, for being configured to white wine, grape wine, yellow rice wine and beer.
Priority Applications (1)
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CN201811341537.9A CN109276590A (en) | 2018-11-12 | 2018-11-12 | Composition and purposes rich in procyanidine and Chinese medical extract |
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CN201811341537.9A CN109276590A (en) | 2018-11-12 | 2018-11-12 | Composition and purposes rich in procyanidine and Chinese medical extract |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN110959735A (en) * | 2019-12-17 | 2020-04-07 | 天津市尖峰天然产物研究开发有限公司 | Candy added with vaccinium myrtillus extract and preparation method thereof |
-
2018
- 2018-11-12 CN CN201811341537.9A patent/CN109276590A/en not_active Withdrawn
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110959735A (en) * | 2019-12-17 | 2020-04-07 | 天津市尖峰天然产物研究开发有限公司 | Candy added with vaccinium myrtillus extract and preparation method thereof |
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Application publication date: 20190129 |