CN109452281A - A kind of bactericidal composition containing isopropyl metsulfovax and fenhexamid - Google Patents
A kind of bactericidal composition containing isopropyl metsulfovax and fenhexamid Download PDFInfo
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- CN109452281A CN109452281A CN201811589891.3A CN201811589891A CN109452281A CN 109452281 A CN109452281 A CN 109452281A CN 201811589891 A CN201811589891 A CN 201811589891A CN 109452281 A CN109452281 A CN 109452281A
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- fenhexamid
- metsulfovax
- isopropyl metsulfovax
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/10—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with sulfur as the ring hetero atom
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
- A01N37/22—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides
- A01N37/24—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof the nitrogen atom being directly attached to an aromatic ring system, e.g. anilides containing at least one oxygen or sulfur atom being directly attached to the same aromatic ring system
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- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
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- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses the bactericidal compositions and its application of a kind of metsulfovax containing isopropyl and fenhexamid, effective active composition is made of the first active constituent isopropyl metsulfovax and the second active constituent fenhexamid, the weight ratio of first active constituent and the second active constituent is 1:60~60:1, preferably 1:40~40:1.This composition can be configured to the wettable powder agriculturally allowed, water dispersible granules, suspending agent, suspoemulsion, aqueous emulsion, micro-emulsion form.Instant component is reasonable, and bactericidal effect is good, and its activity and bactericidal effect are not the active simple superposition of each component, compared with existing single formulation, in addition to significant bactericidal effect, and have significant synergistic effect, good to crop safety.The present invention has significant control efficiency to crop gray mold, sclerotiniose, scab, powdery mildew and brown spot.
Description
Technical field
The present invention relates to a kind of bactericidal compositions, by the first active constituent isopropyl metsulfovax and the second active constituent ring acyl bacterium
Amine and auxiliary agent composition, belong to technical field of compounded pesticide.
Background technique
Isopropyl metsulfovax, English name isofetamid, chemical name are N- [1,1- dimethyl -2- (4- isopropyl oxygen
Base-o-tolyl) -2- oxoethyl] -3 methyl thiophene -2- formamide.One kind of Japanese Ishihara Sangyo Kaisha, Ltd.'s exploitation
Acid amide fungicides mainly act on the succinate dehydrogenase in pathogen, inhibit its breathing to play a role.2014
It is listed by Summit Agro in the U.S., for preventing and treating sclerotiniose caused by gray mold caused by Botrytis cinerea and sclerotinite.
Fenhexamid, English name fenhexamid, chemical name are N- (2,3- bis- chloro- 4- hydroxy phenyl) -1- first
Butylcyclohexane formamide.Fenhexamid is mainly used for rice field prevention and treatment rice blast, various gray molds and relevant sclerotiniose, blackspot
Disease etc. has special efficacy to gray mold.
Applicant is through retrieving, and there is presently no the reports of isopropyl metsulfovax and fenhexamid mixture prevention and treatment plant fungal disease
Road is further found by experiment that, the different isopropyl metsulfovax of the mechanism of action and fenhexamid are compounded, and is had unexpected
Effect, synergistic effect excellent to the fungal diseases control efficiency such as crop gray mold, sclerotiniose, scab, powdery mildew, brown spot
Obviously, dosage is reduced, and control cost reduces, to crop safety.
Summary of the invention
The purpose of the present invention is to provide a kind of component is reasonable, synergistic effect is significant, and bactericidal effect is good, and drug cost is low,
To the bactericidal composition containing isopropyl metsulfovax and fenhexamid of crop safety.
Another object of the present invention is to provide the bactericidal composition preparation formulations containing isopropyl metsulfovax and fenhexamid.
A further object of the present invention is to provide above-mentioned compositions in prevention and treatment crop gray mold, sclerotiniose, scab, white powder
Application on the fungal diseases such as disease, brown spot.
In order to overcome the defect of existing single formulation, the technical scheme is that solve in this way:
A) the first active constituent isopropyl metsulfovax；
B) the second active constituent fenhexamid；
The weight ratio of first active constituent and the second active constituent is 1:60~60:1, preferably 1:40~40:1.
The sum of content of first active constituent and the second active constituent is the 1%~80% of the composition total weight, preferably
It is 1%~60%.
A kind of bactericidal composition containing isopropyl metsulfovax and fenhexamid of the present invention, according to those skilled in the art of the present technique
The preparation formulation that known method can be prepared is wettable powder, water dispersible granules, suspending agent, suspoemulsion, aqueous emulsion, micro-
Emulsion.
To wettable powder, workable auxiliary agent has: dispersing agent such as polycarboxylate, lignosulfonates, polyoxyethylene is poly-
Oxypropylene group ether block copolymers, alkyl naphthalene formaldehyde condensate sulfonate, alkylphenol-polyethenoxy base ether phosphate, poly alkyl alcohol
One of ethylene oxide ether phosphate, alkylphenol polyoxyethylene ether sulfonate etc. are a variety of；Wetting agent such as alkyl sulfate, alkane
One of base sulfonate, alkylnaphthalene sulfonate etc. are a variety of；Filler such as ammonium sulfate, urea, sucrose, glucose, diatomite, height
One of ridge soil, white carbon black, light calcium, talcum powder, attapulgite, clay etc. are a variety of.
To water dispersible granules, workable auxiliary agent has: dispersing agent such as polycarboxylate (TERSPERSE2700, T36, GY-D06
Deng), lignosulfonates, one of alkylnaphthalene sulfonate etc. or a variety of；Wetting agent for example alkyl sulfate, alkylsulfonate,
One of naphthalene sulfonate etc. is a variety of；Disintegrating agent such as ammonium sulfate, sodium sulphate, polyvinylpyrrolidone, starch and its derivative,
One of bentonite etc. is a variety of；Binder for example starch, glucose, polyvinyl alcohol, polyethylene glycol, sodium carboxymethylcellulose,
One of sucrose etc. is a variety of；Filler such as diatomite, kaolin, white carbon black, light calcium, talcum powder, attapulgite, in clay
It is one or more.
To suspending agent, workable auxiliary agent has: dispersing agent such as polycarboxylate, lignosulfonates, alkyl naphthalene formaldehyde condensation
Object sulfonate, alkylphenol-polyethenoxy base ether phosphate, alkylphenol polyoxyethylene ether sulfonate, phenethyl phenol polyoxyethylene groups
Ether phosphate, alkyl polyoxyethylene ether sulfonate, polyoxyethylene polyoxypropylene base ether block copolymers, pull open powder, dodecyl
One of polyoxyethylene ether phosphate etc. is a variety of；Wetting agent such as alkylphenol polyoxyethylene ether formaldehyde condensate sulfate,
Phenethyl phenol polyoxyethylene groups ether phosphate, alkyl sulfate, alkylsulfonate, alkylnaphthalene sulfonate, alkylphenol-formaldehyde resin
One of polyoxyethylene ether, triphenoethyl benzene phenol polyoxyethylene polyoxypropylene block polymer etc. are a variety of；Thickener is such as yellow
One of virgin rubber, polyvinyl alcohol, bentonite, aluminium-magnesium silicate, carboxymethyl cellulose, carboxyethyl cellulose, methylcellulose etc.
Or it is a variety of；One of preservative such as formaldehyde, benzoic acid, sodium benzoate, potassium sorbate, isothiazolinone etc. is a variety of；Defoaming
Agent such as silicone oil, silicone compound, C10-20 saturated fat acid compounds, C8-10 fatty alcohols, hexanol, butanol, octanol etc.
One of or it is a variety of；Antifreezing agent such as ethylene glycol, propylene glycol, glycerine, polyethylene glycol, sorbierite, urea, in inorganic salts
It is one or more；Water is deionized water.
To suspoemulsion, workable auxiliary agent has: emulsifier for example calcium dodecyl benzene sulfonate (agriculture breast 500#), Nongru-700 #,
Agriculture breast 2201, this disk -60#, emulsifier T-60(common name: anhydrous sorbitol single-hard ester acid ester polyoxyethylene ether), TX-10(it is logical
With name: octylphenol polyethylene ethylene oxide (10) ether), agriculture breast 1601#, agriculture breast 600#, one of agriculture breast 400# or a variety of；Dispersing agent is such as
It is polycarboxylate, lignosulfonates, one or more in alkylnaphthalene sulfonate；Solvent such as repefral, adjacent benzene two
It is formic acid dibutyl ester, ethyl acetate, one or more in methyl benzoate；Defoaming agent is as such as silicone oil, silicone compound, C10-20
One of saturated fat acids compound, C8-10 fatty alcohols, hexanol, butanol, octanol are a variety of；Thickener such as white carbon black,
It is polyvinyl alcohol, bentonite, one or more in aluminium-magnesium silicate；Antifreeze such as ethylene glycol, propylene glycol, glycerol, urea, inorganic salts
As one or more in sodium chloride；Water is deionized water.
To aqueous emulsion, workable auxiliary agent has: emulsifier such as Nonyl pheno (EO=10) ether phosphate, triphen second
Base phenol polyoxyethylene phosphonate, Nongru-700 #(alkyl phenol formaldehyde resin polyoxyethylene ether), agriculture breast 2201#, this disk -60#
(Span60), Tween-60 #(polyoxyethylene sorbitan stearate), TX-10(octyl phenol polyoxy second
Alkene (10) ether), agriculture breast 1601(triphenoethyl benzene phenol polyoxyethylene polyoxypropylene block polymer), agriculture breast 600#, agriculture breast 400#
Deng one of or it is a variety of；Solvent such as dimethylbenzene, toluene, cyclohexanone, in solvent naphtha (trade mark: S-150, S-180, S-200)
It is one or more；One of stabilizer such as triphenyl phosphite, epoxychloropropane, epoxidized soybean oil etc. is a variety of；It is antifreeze
One of agent such as ethylene glycol, propylene glycol, glycerol, urea, inorganic salts such as sodium chloride etc. is a variety of；Thickener such as xanthan gum,
One of polyvinyl alcohol, bentonite, aluminium-magnesium silicate etc. are a variety of；Preservative such as formaldehyde, benzoic acid, one in sodium benzoate
Kind is a variety of, and water is deionized water.
To microemulsion, workable auxiliary agent has: emulsifier such as agriculture breast 500#(calcium dodecyl benzene sulfonate), Nongru-700 #,
Agriculture breast 2201, this disk-60#, polysorbate60-#, TX-10, agriculture breast 1601(phenethyl phenol polyoxyethylene poly-oxygen propylene aether), agriculture breast
One of 600#, agriculture breast 400# etc. or a variety of；One of assistant for emulsifying agent such as methanol, isopropanol, n-butanol, ethyl alcohol etc. is more
Kind；Solvent such as cyclohexanone, N-Methyl pyrrolidone, dimethylbenzene, toluene, in solvent naphtha (trade mark: S-150, S-180, S-200)
It is one or more；One of stabilizer such as triphenyl phosphite, epoxychloropropane etc. is a variety of；Water is deionized water.
Instant component is reasonable, and bactericidal effect is good, and drug cost is low, and its activity and bactericidal effect are not each component activity
Simple superposition, but have significant synergistic effect, it is good to crop safety, meet the security requirement of pesticidal preparations.This hair
It is bright that there is excellent control efficiency to fungal diseases such as crop gray mold, sclerotiniose, scab, powdery mildew, brown spots.
Specific embodiment
Mixed synergy measurement to gray mold.
In order to prevent and treat the gray mold in agricultural production, we with isopropyl metsulfovax with the progress of fenhexamid is mutual compounds
Synergy research, the specific method is as follows.
Test using graw mold of tomato (Botrytis cinerea) it is test object.Raw medicine is configured to the test needed
Medicament, 5 various concentration gradients are arranged in single dose and each Mixed Pharmacy, and (on the basis of preliminary experiment result, bacteriostasis rate is 5%
It is set in the range of~90% by geometric progression).If clear water compares, it is repeated 4 times.Test uses mycelial growth rate method, will cultivate
Good pathogen, is aseptically 5mm punch with diameter, cuts bacteria cake from colony edge, connect bacteria cake with transfer needle
In on the culture medium flat plate of different agents concentration, setting 22 DEG C, cultivate in saturated humidity incubator；When control group bacterium colony covers with, survey
Colony diameter is measured, the percentage that each chemicals treatment inhibits mycelia growth is calculated, passes through the probit value of inhibiting rate and series of concentrations
Linear regression analysis between logarithm finds out the EC of each medicament50Value calculates the co-toxicity coefficient of mixture with Sun Yunpei's Method
(CTC), reagent agent is evaluated to the activity of germ with this.
The co-toxicity coefficient (CTC) >=120 of compound preparation shows as synergistic effect；CTC≤80 show as antagonism；80 <
CTC < 120 shows as being added
Effect.
1 isopropyl metsulfovax of table and fenhexamid measure the mixed synergy of graw mold of tomato
Synergy measurement result shows: isopropyl metsulfovax is mixed by 1:80~80:1 with fenhexamid, to botrytis cinerea
It shows different activity: when ratio is 1:60~60:1, showing as synergistic effect；When ratio is 1:40~40:1, increase
Effect effect becomes apparent from.
Mixed synergy measurement to sclerotiniose.
In order to prevent and treat the sclerotiniose in agricultural production, we with isopropyl metsulfovax with the progress of fenhexamid is mutual compounds
Synergy research, the specific method is as follows.
Test using Sclerotinia sclerotiorum (Sclerotinia sclerotiorum) it is test object.Raw medicine is configured to
The test medicine needed, by single dose and each Mixed Pharmacy be arranged 5 various concentration gradients (on the basis of preliminary experiment result,
Bacteriostasis rate is set in the range of 5%~90% by geometric progression).If clear water compares, it is repeated 4 times.Test is using mycelia growth speed
Cultured pathogen is aseptically 5mm punch with diameter, bacteria cake is cut from colony edge, with inoculation by rate method
Bacteria cake is connected on the culture medium flat plate of different agents concentration by needle, is set 20 DEG C, is cultivated in saturated humidity incubator；To control group bacterium colony
When covering with, colony diameter is measured, calculates the percentage that each chemicals treatment inhibits mycelia growth, by the probit value of inhibiting rate and is
Linear regression analysis between the logarithm of column concentration finds out the EC of each medicament50Value calculates the total poison of mixture with Sun Yunpei's Method
Coefficient (CTC) evaluates reagent agent to the activity of germ with this.
The co-toxicity coefficient (CTC) >=120 of compound preparation shows as synergistic effect；CTC≤80 show as antagonism；80 <
CTC < 120 shows as summation action.
2 isopropyl metsulfovax of table and fenhexamid measure the mixed synergy of sclerotinia sclerotiorum
Synergy measurement result shows: isopropyl metsulfovax is mixed by 1:80~80:1 with fenhexamid, to Sclerotinia sclerotiorum
It shows different activity: when ratio is 1:60~60:1, showing as synergistic effect；When ratio is 1:40~40:1, increase
Effect effect becomes apparent from.
Mixed synergy measurement to scab.
In order to prevent and treat the scab in agricultural production, we with isopropyl metsulfovax with the progress of fenhexamid is mutual compounds
Synergy research, the specific method is as follows.
Test using pear cucumerinum (Venturia pirina) it is test object.Raw medicine is configured to the test needed
Medicament, 5 various concentration gradients are arranged in single dose and each Mixed Pharmacy, and (on the basis of preliminary experiment result, bacteriostasis rate is 5%
It is set in the range of~90% by geometric progression).If clear water compares, it is repeated 4 times.Test uses mycelial growth rate method, will cultivate
Good pathogen, is aseptically 5mm punch with diameter, cuts bacteria cake from colony edge, connect bacteria cake with transfer needle
In on the culture medium flat plate of different agents concentration, setting 21 DEG C, cultivate in saturated humidity incubator；When control group bacterium colony covers with, survey
Colony diameter is measured, the percentage that each chemicals treatment inhibits mycelia growth is calculated, passes through the probit value of inhibiting rate and series of concentrations
Linear regression analysis between logarithm finds out the EC of each medicament50Value calculates the co-toxicity coefficient of mixture with Sun Yunpei's Method
(CTC), reagent agent is evaluated to the activity of germ with this.
The co-toxicity coefficient (CTC) >=120 of compound preparation shows as synergistic effect；CTC≤80 show as antagonism；80 <
CTC < 120 shows as summation action.
3 isopropyl metsulfovax of table and fenhexamid measure the mixed synergy of pear scab
Synergy measurement result shows: isopropyl metsulfovax is mixed by 1:80~80:1 with fenhexamid, to pear cucumerinum table
Reveal different activity: when ratio is 1:60~60:1, showing as synergistic effect；When ratio is 1:40~40:1, synergy
Effect becomes apparent from.
Mixed synergy measurement to powdery mildew.
In order to prevent and treat the powdery mildew in agricultural production, we with isopropyl metsulfovax with the progress of fenhexamid is mutual compounds
Synergy research, the specific method is as follows.
Subjects be cucumber powdery mildew's pathogen (Sphaerotheca fuliginea).Raw medicine is configured to the test needed
Medicament, test method with reference to " the 6th part of farm-chemical indoor determination test rule fungicide: mixed synergy measurement " and
" the 11st part of farm-chemical indoor determination test rule fungicide: prevention and treatment cucurbits powdery mildew tests pot-culture method ".
5 various concentration gradients are arranged in single dose and each Mixed Pharmacy first, and (on the basis of preliminary experiment, bacteriostasis rate exists
It is set in the range of 5%~90% by geometric progression).If blank control is repeated 4 times.Using pot-culture method, medical fluid is uniformly sprayed on
Blade face, it is spare after medical fluid natural air drying.With spore suspension spray inoculation, then natural air drying moves to thermostatic chamber, in temperature
Under conditions of 20~24 DEG C, 7d~10d is cultivated.When blank control disease leaf rate reaches 80% or more, classification investigation is got a haircut everywhere
30 leaves are at least investigated in state of an illness condition, every processing.Grade scale are as follows:
0 grade: disease-free；
1 grade: lesion area accounts for 5% or less entire leaf area；
3 grades: lesion area accounts for the 5%~15% of entire leaf area；
5 grades: lesion area accounts for the 15%~25% of entire leaf area；
7 grades: lesion area accounts for the 25%~50% of entire leaf area；
9 grades: lesion area accounts for the 50%~75% of entire leaf area；
11 grades: lesion area accounts for 75% or more of entire leaf area；
According to survey data, the disease index and control efficiency of each processing are calculated.Pass through pair of preventive effect probability value and series of concentrations
Linear regression analysis between numerical value finds out the EC50 value of each medicament.
The co-toxicity coefficient (CTC) of mixture is calculated with Sun Yunpei's Method, and reagent agent is evaluated to the activity of germ with this.Compounding
The co-toxicity coefficient (CTC) >=120 of preparation shows as synergistic effect；CTC≤80 show as antagonism；80 < CTC < 120 performance
For summation action.
4 isopropyl metsulfovax of table and fenhexamid measure the mixed synergy of powdery mildew of cucumber
Synergy measurement result shows: isopropyl metsulfovax is mixed by 1:80~80:1 with fenhexamid, to cucumber powdery mildew's pathogen
It shows different activity: when ratio is 1:60~60:1, showing as synergistic effect；When ratio is 1:40~40:1, increase
Effect effect becomes apparent from.
Mixed synergy measurement to brown spot.
In order to prevent and treat the brown spot in agricultural production, we with isopropyl metsulfovax with the progress of fenhexamid is mutual compounds
Synergy research, the specific method is as follows.
Test using apple marssonina leaf spot (Marssonina coronaria) it is test object.Raw medicine is configured to needs
Test medicine, by single dose and each Mixed Pharmacy be arranged 5 various concentration gradients (on the basis of preliminary experiment result, bacteriostasis rate
It is set in the range of 5%~90% by geometric progression).If clear water compares, it is repeated 4 times.Test uses mycelial growth rate method, will
Cultured pathogen is aseptically 5mm punch with diameter, cuts bacteria cake from colony edge, with transfer needle by bacterium
Cake is connected on the culture medium flat plate of different agents concentration, is set 23 DEG C, is cultivated in saturated humidity incubator；It is covered with to control group bacterium colony
When, colony diameter is measured, the percentage that each chemicals treatment inhibits mycelia growth is calculated, it is dense by the probit value and series of inhibiting rate
Linear regression analysis between the logarithm of degree finds out the EC of each medicament50Value calculates the co-toxicity coefficient of mixture with Sun Yunpei's Method
(CTC), reagent agent is evaluated to the activity of germ with this.
The co-toxicity coefficient (CTC) >=120 of compound preparation shows as synergistic effect；CTC≤80 show as antagonism；80 <
CTC < 120 shows as summation action.
5 isopropyl metsulfovax of table and fenhexamid measure the mixed synergy of apple marssonina leaf spot
Synergy measurement result shows: isopropyl metsulfovax is mixed by 1:80~80:1 with fenhexamid, to marssonina coronaria
It shows different activity: when ratio is 1:60~60:1, showing as synergistic effect；When ratio is 1:40~40:1, increase
Effect effect becomes apparent from.
In order to better illustrate the present invention, the content of present invention is described further below with reference to embodiment, in formula
Percentage is weight percentage.
Example of formulations 1
Weigh 4% isopropyl metsulfovax, 40% fenhexamid, 5% alkylphenol polyoxyethylene ether sulfonate, 8% aliphatic alcohol polyethenoxy
Ether phosphate, 3% Negel, diatomite are filled up to 100% parts by weight.Above-mentioned raw materials through mixing, ultra micro air-flow crushing,
Hybrid technique step is prepared into 44% isopropyl metsulfovax fenhexamid wettable powder.
Example of formulations 2
Weigh 5% isopropyl metsulfovax, 40% fenhexamid, 5% sodium polycarboxylate, 2% alkylphenol-polyethenoxy base ether phosphate, 4% 12
Sodium alkyl sulfate, talcum powder are filled up to 100% parts by weight.Above-mentioned raw materials are through mixing, ultra micro air-flow crushing, hybrid technique step
It is prepared into 45% isopropyl metsulfovax fenhexamid wettable powder.
Example of formulations 3
Weigh 3% isopropyl metsulfovax, 30% fenhexamid, 4% sodium lignin sulfonate, 6% Negel, 4% Nekal BX (two
Sodium butylnaphthalenesulfonate), 2% lauryl sodium sulfate, 3% bentonite, attapulgite adds to 100% parts by weight.Above-mentioned raw materials are through routine
The method for producing water dispersible granules mixes, ultra micro air-flow crushing, mixing, granulation step produce 33% isopropyl metsulfovax ring acyl
Bacterium aqueous amine dispersible granule.
Example of formulations 4
Weigh 2% isopropyl metsulfovax, 28% fenhexamid, 5% Negel, 4% sodium lignin sulfonate, 3% Nekal BX (two
Sodium butylnaphthalenesulfonate), 2% sodium alkyl sulfonate, 3% sodium carboxymethylcellulose, talcum powder adds to 100% parts by weight.Above-mentioned raw materials are frequent
Method i.e. mixing, ultra micro air-flow crushing, mixing, the granulation step of regulation water intaking dispersible granule produces 30% isopropyl metsulfovax ring
Acyl bacterium aqueous amine dispersible granule.
Example of formulations 5
Weigh 35% isopropyl metsulfovax, 30% fenhexamid, 5% alkyl naphthalene formaldehyde condensate sulfonate, 6% sodium lignin sulfonate, 5%
Sodium alkyl sulfate, 0.8% carboxymethyl cellulose, 2% sodium benzoate, 0.6% potassium sorbate, 1.8% butanol, deionized water add to 100%
Parts by weight.For above-mentioned raw materials through mixing, high speed shear disperses 30min, is sanded with sand mill to partial size D9033% is made after less than 10 μm
Isopropyl metsulfovax fenhexamid suspending agent.
Example of formulations 6
Weigh 6% isopropyl metsulfovax, 24% fenhexamid, 4% alkyl naphthalene formaldehyde condensation product sodium sulfonate, 5% triphenoethyl benzene phenol polyoxy
Propylene polyoxyethylene block polymers, 4% sodium alkyl sulfate, 1% xanthan gum, 3% sorbierite, 0.6% potassium sorbate, 2% butanol, go
Ionized water adds to 100% parts by weight.For above-mentioned raw materials through mixing, high speed shear disperses 30min, is sanded with sand mill to partial size D90It is small
30% isopropyl metsulfovax fenhexamid suspending agent is made after 10 μm.
Example of formulations 7
Weigh 3% isopropyl metsulfovax, 30% fenhexamid, 6% 3 phenethyl phenol polyoxyethylene ether phosphate, 5% dispersing agent NNO,
5% sodium polycarboxylate, 3% castor oil, 5% methyl oleate, 4% this disk -60#, 3% dispersing agent TERSPERSE 2500,2% bentonite,
0.6% xanthan gum, 5% propylene glycol, 1% epoxychloropropane, 0.3% benzoic acid, 0.4% butanol, deionized water add to 100% parts by weight.
Above-mentioned raw materials are uniformly mixed, and high speed shear disperses 30min, and 33% isopropyl metsulfovax fenhexamid is made after being sanded with sand mill
Suspoemulsion.
Example of formulations 8
Weigh 4% isopropyl metsulfovax, 20% fenhexamid, 4% sodium lignin sulfonate, 6% methyl oleate, 5% soybean oil, 4% agriculture breast
600#, 4% Tween-60 #, 3% alkylphenol-polyethenoxy base ether phosphate, 2% aluminium-magnesium silicate, 0.5% xanthan gum, 5% ethylene glycol, 3%
Triphenyl phosphite, 0.5% sodium benzoate, 0.8% octanol, deionized water add to 100% parts by weight.Above-mentioned raw materials are uniformly mixed, high
Speed shearing dispersion 30min, is made 24% isopropyl metsulfovax fenhexamid suspoemulsion after being sanded with sand mill.
Example of formulations 9
Weigh 3% isopropyl metsulfovax, 30% fenhexamid, 6% agriculture breast 600#, 4% agriculture breast 2201#, 5% Span60,
3% this disk -60#, 1% epoxychloropropane, 4% sodium chloride, 3% toluene, 0.6% aluminium-magnesium silicate, 0.5% sodium benzoate, deionized water add
To 100% parts by weight.For above-mentioned raw materials through mixing, 33% isopropyl metsulfovax fenhexamid aqueous emulsion is made in high speed shearing emulsification.
Example of formulations 10
Weigh 2% isopropyl metsulfovax, 24% fenhexamid, 7% agriculture breast 2201#, 4% Nongru-700 #, 5% Tween-60 #, 3% urea, 6%
Solvent naphtha S-200,4% formaldehyde, 0.4% polyvinyl alcohol, 0.4% formaldehyde, deionized water add to 100% parts by weight.Above-mentioned raw materials are through mixed
It closes, 26% isopropyl metsulfovax fenhexamid aqueous emulsion is made in high speed shearing emulsification.
Example of formulations 11
Weigh 3% isopropyl metsulfovax, 30% fenhexamid, 4% agriculture breast 1601,6% agriculture breast, 2201,6% this disk -60,10% dimethylbenzene, 4%
Cyclohexanone, 2% methanol, 5% triphenyl phosphite are dissolved completely and are uniformly mixed, and deionized water adds to 100% parts by weight, stirring
33% isopropyl metsulfovax fenhexamid microemulsion is made afterwards.
Example of formulations 12
Weigh 2% isopropyl metsulfovax, 34% fenhexamid, 5% agriculture breast 2201,4% polysorbate60-#, 8% solvent naphtha S-180,5% toluene,
3% n-butanol, 3% triphenyl phosphite are dissolved completely and are uniformly mixed, and deionized water adds to 100% parts by weight, makes after stirring
Obtain 36% isopropyl metsulfovax fenhexamid microemulsion.
Biological Examples 1: prevention and treatment graw mold of tomato field control effectiveness test.
Example of formulations 1(44% isopropyl metsulfovax fenhexamid wettable powder has been carried out in Shaanxi Province Jingyang County within 2018
Agent), example of formulations 3(33% isopropyl metsulfovax fenhexamid water dispersible granules), prevention and treatment graw mold of tomato field trial, test
Control efficiency of the medicament to graw mold of tomato and the safety to tomato are demonstrate,proved.
Trial crops are tomato, controlling object be graw mold of tomato (Botrytis cinerea).Test is located at Jingyang County
Yunyang town, experimental plot topography is flat, and soil is loam, and middle fertility, pH value 6.9, fertilizer and water management is medium during test.Investigational agent
See Table 6 for details for agent and dosage.Separately set blank control, 4 repetitions of every processing, every 30 ㎡ of cell, random district's groups arrangement.Using conventional spray
Mist method, mu are administered liquid 45kg, are uniformly sprayed at leave dual sides.
Investigation and statistical method: state of an illness radix is investigated before the 1st application, 10~14d is reinvestigated after last time is administered
Once, it investigates 2 times, is administered 2 times altogether.Every cell uses five point sampling, and every is investigated 3 plants, and whole blades of every plant of investigation are counted
Calculate disease index.Graw mold of tomato grade scale (as unit of blade):
0 grade: disease-free spot；
1 grade: single blade has scab 3；
3 grades: single blade has scab 4~6；
5 grades: single blade has scab 7~10；
7 grades: single blade has scab 11~20, and part is intensive in blocks；
9 grades: single blade has scab intensively to account for leaf area a quarter or more.
Disease index=[∑ (the disease numbers of sheets at different levels × opposite value of series)/(investigation total leaf number × 9)] × 100
Control efficiency (%)=[1- (disease index after disease index × processing application before control is administered)/(state of an illness refers to after control application
Disease index before number × processing is administered] × 100
Table 6 prevents and treats graw mold of tomato field test results
Table of field test results are bright, and example of formulations 1 and 3 pair graw mold of tomato has good control efficiency, by 100g a.i./
hm22 times spraying, 10 days preventive effects are above 70% after the 2nd medicine, with 36% isopropyl metsulfovax suspending agent 9.1g of comparison medicament
a.i./hm2, 50% fenhexamid suspending agent 90.9g a.i./hm2Preventive effect compares, and synergistic effect is significant.By to the 2nd medicine
10 days preventive effect significance difference analysis afterwards, embodiment chemicals treatment and comparison medicament processing preventive effect difference reach extremely significant level.
Security survey to tomato is observed after spray for several days after the 1st day and medicine, and each test process is to tomato without phytotoxicity
Phenomenon occurs.
Biological Examples 2: prevention and treatment sclerotinia sclerotiorum field trial.
Example of formulations 5(33% isopropyl metsulfovax fenhexamid suspending agent has been carried out in Shaanxi Province's Hanzhong City within 2018),
Example of formulations 7 (33% isopropyl metsulfovax fenhexamid suspoemulsion) prevents and treats sclerotinia sclerotiorum field trial, demonstrates the medicament
Control efficiency to sclerotinia sclerotiorum and the safety to rape.Trial crops are rape, and controlling object is sclerotinia sclerotiorum
(Sclerotinia sclerotiorum).Test is located at Hanzhong City Yang County Huayang town, and experimental plot topography is flat, and soil is yellowish-brown
Loam, middle fertility, pH value 7.1, fertilizer and water management is medium during test.See Table 7 for details for test medicine and dosage.Separately set blank pair
According to, 4 repetitions of every processing, every 40 ㎡ of cell, random district's groups arrangement.Using conventional spray-on process, mu is administered liquid 45kg, uniformly sprays
In leave dual sides.
Investigation and statistical method: investigating state of an illness radix before application, 10~14d is reinvestigated once after last time is administered, altogether
Investigation 2 times.10 points of every cell checkerboard type investigation, every is investigated 5 plants, and when investigation is careful not to sample in side row.Stage division:
0 grade: disease-free spot；
1 grade: slight morbidity, onset area account for 5% or less stem surface area；
3 grades: slight morbidity, onset area account for the 6%~15% of stem surface area；
5 grades: medium morbidity, onset area account for the 16%~30% of stem surface area；
7 grades: height is fallen ill, and onset area accounts for the 31%~50% of stem surface area；
9 grades: serious morbidity, onset area account for 50% or more of stem surface area.
Disease index=[∑ (diseased plant numbers at different levels × opposite value of series)/(investigating total strain the piece number × 9)] × 100
Control efficiency (%)=[1- (disease index after disease index × processing application before control is administered)/(state of an illness refers to after control application
Disease index before number × processing is administered] × 100
Table 7 prevents and treats sclerotinia sclerotiorum field test results
Table of field test results are bright, and example of formulations 5 and 7 pair sclerotinia sclerotiorum has good control efficiency, by 100g a.i./
hm22 times spraying, 10 days preventive effects are above 65% after the 2nd medicine, with 36% isopropyl metsulfovax suspending agent 9.1g of comparison medicament
a.i./hm2, 50% fenhexamid suspending agent 90.9g a.i./hm2Preventive effect compares, and synergistic effect is significant.By to the 2nd medicine
10 days preventive effect significance difference analysis afterwards, embodiment chemicals treatment and comparison medicament processing preventive effect difference reach extremely significant level.
Security survey to rape is observed after spray for several days after the 1st day and medicine, and each test process is to rape without phytotoxicity
Phenomenon occurs.
Biological Examples 3: prevention and treatment powdery mildew of cucumber field trial.
Example of formulations 9(33% isopropyl metsulfovax fenhexamid aqueous emulsion has been carried out in Shouguang City, Shandong Province within 2018),
Example of formulations 11(21% isopropyl metsulfovax fenhexamid microemulsion) prevention and treatment powdery mildew of cucumber field trial, demonstrate the medicine
Control efficiency of the agent to powdery mildew of cucumber and the safety to cucumber.Trial crops are cucumber, and controlling object is powdery mildew of cucumber
(Sphaerotheca fuliginea).Test is located at Shouguang City, the rice field Zhen Dong village, rice field, and experimental plot topography is flat, and soil is earth
Soil, middle fertility, pH value 6.9, fertilizer and water management is medium during test.See Table 8 for details for test medicine and dosage.Blank control separately is set,
4 repetitions of every processing, every 30 ㎡ of cell, random district's groups arrangement.Using conventional spray-on process, mu is administered liquid 45kg, is uniformly sprayed at
Leave dual sides.
Investigation and statistical method: investigating state of an illness radix before application, 10~14d is reinvestigated once after last time is administered, altogether
Investigation 2 times.Every cell takes at 4 points at random, and whole blades of every 2 plants of investigation, every leaf accounts for the percentage of leaf area according to scab
Classification record.Stage division:
0 grade: disease-free spot；
1 grade: lesion area accounts for 5% or less entire leaf area；
3 grades: lesion area accounts for the 6%~10% of entire leaf area；
5 grades: lesion area accounts for the 11%~20% of entire leaf area；
7 grades: lesion area accounts for the 21%~40% of entire leaf area；
9 grades: lesion area accounts for 40% or more of entire leaf area.
Disease index=[∑ (the disease numbers of sheets at different levels × opposite value of series)/(investigation total leaf number × 9)] × 100
Control efficiency (%)=[1- (disease index after disease index × processing application before control is administered)/(state of an illness refers to after control application
Disease index before number × processing is administered] × 100
Table 8 prevents and treats powdery mildew of cucumber field test results
Table of field test results are bright, and example of formulations 9 and 11 pair powdery mildew of cucumber has good control efficiency, by 90g a.i./
hm22 times spraying, 10 days preventive effects are above 60% after the 2nd medicine, with 36% isopropyl metsulfovax suspending agent 8.2g of comparison medicament
a.i./hm2, 50% fenhexamid suspending agent 81.8g a.i./hm2Preventive effect compares, and synergistic effect is significant.By to the 2nd medicine
10 days preventive effect significance difference analysis afterwards, embodiment chemicals treatment and comparison medicament processing preventive effect difference reach extremely significant level.
Security survey to cucumber is observed after spray for several days after the 1st day and medicine, and each test process is to cucumber without phytotoxicity
Phenomenon occurs.
In addition to above-mentioned graw mold of tomato, sclerotinia sclerotiorum and powdery mildew of cucumber, above-mentioned example of formulations to pear scab and
Apple marssonina leaf spot also has synergistic effect.
Above embodiments explanation, the first active constituent isopropyl metsulfovax and the second active constituent fenhexamid are by weight 1:
60~60:1 compounding, can be made into wettable powder, water dispersible granules, suspending agent, suspoemulsion, aqueous emulsion, micro-emulsion form, to work
Object gray mold, sclerotiniose, scab, powdery mildew, brown spot have significant control efficiency, and synergistic effect is obvious, and dosage is few, anti-
Effect height is controlled, and good to crop safety.
In conclusion composition of the invention is using two kinds of active components compound scheme, activity and bactericidal effect are not
It is the active simple superposition of each component, compared with existing single formulation, other than with significant bactericidal effect, more has significant
Synergistic effect, it is good to crop safety, meet the security requirement of pesticidal preparations.
Claims (6)
1. a kind of bactericidal composition containing isopropyl metsulfovax and fenhexamid, it is characterised in that: the first active constituent is isopropyl
Metsulfovax, the second active constituent are fenhexamid, and the weight ratio of isopropyl metsulfovax and fenhexamid is 1:60~60:1.
2. the bactericidal composition containing isopropyl metsulfovax and fenhexamid according to claim 1, it is characterised in that: isopropyl thiophene
The weight ratio of bacterium amine and fenhexamid is 1:40~40:1.
3. the bactericidal composition containing isopropyl metsulfovax and fenhexamid according to claim 1, it is characterised in that: isopropyl thiophene
The total weight of bacterium amine and fenhexamid accounts for composition total weight 1~80%.
4. the bactericidal composition containing isopropyl metsulfovax and fenhexamid according to claim 1, it is characterised in that: isopropyl thiophene
The total weight of bacterium amine and fenhexamid accounts for composition total weight 1~60%.
5. the bactericidal composition containing isopropyl metsulfovax and fenhexamid according to claim 1, it is characterised in that: composition
Dosage form is wettable powder, water dispersible granules, suspending agent, suspoemulsion, aqueous emulsion, microemulsion.
6. the bactericidal composition containing isopropyl metsulfovax and fenhexamid according to claim 1, it is characterised in that: described to kill
Bacteria composition is for preventing and treating crop gray mold, sclerotiniose, scab, powdery mildew and brown spot.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101917858A (en) * | 2007-11-05 | 2010-12-15 | 石原产业株式会社 | Fungicidal composition and method for controlling noxious fungi |
| CN108402043A (en) * | 2018-03-23 | 2018-08-17 | 北京科发伟业农药技术中心 | A kind of bactericidal composition of the metsulfovax containing isopropyl |
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2018
- 2018-12-25 CN CN201811589891.3A patent/CN109452281A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101917858A (en) * | 2007-11-05 | 2010-12-15 | 石原产业株式会社 | Fungicidal composition and method for controlling noxious fungi |
| CN108402043A (en) * | 2018-03-23 | 2018-08-17 | 北京科发伟业农药技术中心 | A kind of bactericidal composition of the metsulfovax containing isopropyl |
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