CN109419846A - A kind of application of Herba Moslae volatile oil in treatment norovirus infectious diarrhea - Google Patents

A kind of application of Herba Moslae volatile oil in treatment norovirus infectious diarrhea Download PDF

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CN109419846A
CN109419846A CN201710770806.2A CN201710770806A CN109419846A CN 109419846 A CN109419846 A CN 109419846A CN 201710770806 A CN201710770806 A CN 201710770806A CN 109419846 A CN109419846 A CN 109419846A
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volatile oil
herba moslae
elscholtiza
application
moslae volatile
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CN109419846B (en
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赵宽
徐旭东
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Anhui Tiankang Group Co Ltd
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Anhui Tiankang Group Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
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  • Medicines Containing Plant Substances (AREA)
  • Fats And Perfumes (AREA)

Abstract

The invention discloses a kind of application of Herba Moslae volatile oil in treatment norovirus infectious diarrhea, wherein, the total amount of thymol and carvacrol is no less than 60% in Herba Moslae volatile oil, has a better effect to norovirus infectious diarrhea tool, after taking, 2 can daily restore normal.

Description

A kind of application of Herba Moslae volatile oil in treatment norovirus infectious diarrhea
Technical field
The present invention relates to a kind of application of Herba Moslae volatile oil in treatment norovirus infectious diarrhea.
Background technique
Norovirus infectious diarrhea is to belong to diarrhea caused by virus as norovirus, have morbidity is anxious, spread speed is fast, The features such as coverage is wide is the Etiological for causing Non-bacterial diarrhea to break out.Norovirus is infectious strong, with intestinal transmitted Based on, it can be propagated by the water source of pollution, food, article, air etc., often in community, school, restaurant, hospital, nursery, orphan Old institute and army etc. cause collective to break out.
Norovirus, which is broken out, is found in all months.It is some carry out under temperate climate studies have shown that winter it is several The moon is disease incidence peak.Norovirus is being propagated between men by fecal-oral route, and incubation period is 1-2 days.In addition, infection passes The approach of broadcasting further includes the vomitus droplet containing virion, pollutant or the contaminated food of intake and water of airborne.Disease Poison, which is propagated, needs a small amount of virus infection.
In view of norovirus propagation there are many mode (including contacted with environmental surfaces, air borne atomization vomitus and The contact of person to person), Infection outbreak is difficult to control.
The warming cold-damp and damp and hot method in Qinghua is respectively adopted according to its fever and chills difference in norovirus infectious diarrhea.Belong to Cold-damp accumulating in the interior person, it is seen that diarrhea is thin, or even such as water sample, abdominal pain borborygmus, or sees fever, headache, limb aching pain, and tongue fur is white or white Greasy, soft and moderate pulse, treatment should can be added and subtracted based on cold dispelling dampness elimination with huoxiang zhengqi powder；Belong to person in damp and hot wound, it is seen that diarrhea abdomen Bitterly, rush down lower urgent, stool being yellowish-brown, smell is smelly dirty, burning sensation of the anus, dysphoria and thirsty, oliguria with yellow urine, red tongue body, yellow and greasy fur, slippery and rapid pulse Or number is moistened, it treats using clearing heat and promoting diuresis as principle, can be added and subtracted with gegen qinlian decoction.It, can if there is exterior syndromes such as headache, fever, floating pulses Add the dispelling wind and heat such as honeysuckle flower, Fructus Forsythiae, but these prescription therapeutic effects cannot get instant result.
Summary of the invention
The present invention provides a kind of application of Herba Moslae volatile oil in treatment norovirus infectious diarrhea.
To solve the above-mentioned problems, the technical scheme adopted by the invention is that such, a kind of Herba Moslae volatile oil is being treated Application in norovirus infectious diarrhea, the total amount of thymol and carvacrol must not be less than in the Herba Moslae volatile oil 60%, it is preferable that the content of thymol is 48%-60% in Herba Moslae volatile oil.The content of carvacrol is 12%-20%.
Wherein, for the Herba Moslae volatile oil using critical carbon dioxide fluid extraction, extraction temperature is 20~65 DEG C, Preferably 30~40 DEG C, further preferably 35~38 DEG C；Extracting pressure is 5~20Mpa, preferably 8~10Mpa, into one Step is preferably 8.5~8.9Mpa, and extraction time is 1~4 hour, and preferably 1.5~3 hours, further preferably 2~2.5 is small When.
The elscholtiza fine powder is in 30~70 DEG C of low temperature dryings after cleaning elscholtiza, and preferable temperature is 30~60 DEG C, most Good temperature is 30~40 DEG C, is crushed to obtained by 10~20 mesh, most preferably 20 mesh；
The capsule taken orally in pharmacy is made in the various auxiliary materials that the Herba Moslae volatile oil is allowed by the way that pharmacy is added.
The main component of Herba Moslae volatile oil are as follows: carvacrol, to P-cymene, 4- carene, cumyl alcohol, β-pinane The content of alkene and thymol, the elsholtzia oil being prepared using distinct methods, main component is different, finally to norovirus sense There is very big influence in metachromia diarrhea curative effect, through a large amount of experimental studies have found that, in Herba Moslae volatile oil, Moschus in Herba Moslae volatile oil The total amount of careless phenol and carvacrol is no less than 60%, has a better effect to norovirus infectious diarrhea tool, after taking, 2 days Can it restore normal.
The preparation method of Herba Moslae volatile oil provided by the invention is simple, and extraction pressure is small, and temperature is low, and operating condition is easily-controllable System, and no solvent residue, do not destroy active skull cap components and heat-sensitive ingredients, can keep the natural of extract to the maximum extent Feature.
Specific embodiment
In order to deepen the understanding of the present invention, the present invention will be described in further detail with reference to the examples below, the embodiment For explaining only the invention, it is not intended to limit the scope of the present invention..
A kind of embodiment 1: preparation method of Herba Moslae volatile oil
1, raw material preparation: quickly being cleaned up elscholtiza with clear water, sets 30 DEG C of low temperature dryings, and it is thin to be crushed to 20 mesh with pulverizer Powder；
2, it extracting: taking elscholtiza fine powder 600g, using CO 2 fluid extraction equipment, extract volatile oil, extraction temperature is 25 DEG C, Extracting pressure is 8.9Mpa, and extraction time is 2 hours, obtains volatile oil 10.5ml, after measured, thymol (C10H14Containing O) Amount is 48.71%；Carvacrol (C10H14O content) is 13.99%.
A kind of embodiment 2: preparation method of Herba Moslae volatile oil
1, raw material preparation: quickly being cleaned up elscholtiza with clear water, sets 40 DEG C of low temperature dryings, and it is thin to be crushed to 20 mesh with pulverizer Powder；
2, it extracting: taking elscholtiza fine powder 600g, using CO 2 fluid extraction equipment, extract volatile oil, extraction temperature is 39 DEG C, Extracting pressure is 8.7Mpa, and extraction time is 2 hours, obtains volatile oil 9.7ml, after measured, thymol (C10H14O content) It is 50.26%；Carvacrol (C10H14O content) is 16.53%.
A kind of embodiment 3: preparation method of Herba Moslae volatile oil
1, raw material preparation: quickly being cleaned up elscholtiza with clear water, sets 30 DEG C of low temperature dryings, and it is thin to be crushed to 20 mesh with pulverizer Powder；
2, it extracting: taking elscholtiza fine powder 600g, using CO 2 fluid extraction equipment, extract volatile oil, extraction temperature is 28 DEG C, Extracting pressure is 9.2Mpa, and extraction time is 2.5 hours, obtains volatile oil 11.8ml, after measured, thymol (C10H14O) Content is 59.07%；Carvacrol (C10H14O content) is 19.75%.
A kind of embodiment 4: preparation method of Herba Moslae volatile oil
1, raw material preparation: quickly being cleaned up elscholtiza with clear water, sets 30 DEG C of low temperature dryings, and it is thin to be crushed to 20 mesh with pulverizer Powder；
2, it extracting: taking elscholtiza fine powder 600g, using CO 2 fluid extraction equipment, extract volatile oil, extraction temperature is 21 DEG C, Extracting pressure is 8.6Mpa, and extraction time is 2 hours, obtains volatile oil 10.7ml, after measured, thymol (C10H14Containing O) Amount is 53.28%；Carvacrol (C10H14O content) is 17.43%.
A kind of embodiment 5: preparation method of Herba Moslae volatile oil
1, raw material preparation: quickly being cleaned up elscholtiza with clear water, sets 30 DEG C of low temperature dryings, and it is thin to be crushed to 20 mesh with pulverizer Powder；
2, it extracting: taking elscholtiza fine powder 600g, using CO 2 fluid extraction equipment, extract volatile oil, extraction temperature is 36 DEG C, Extracting pressure is 9.5Mpa, and extraction time is 2.5 hours, obtains volatile oil 11.5ml, after measured, thymol (C10H14O) Content is 51.90%；Carvacrol (C10H14O content) is 16.92%.
A kind of embodiment 6: preparation method of Herba Moslae volatile oil
1, raw material preparation: quickly being cleaned up elscholtiza with clear water, sets 30 DEG C of low temperature dryings, and it is thin to be crushed to 20 mesh with pulverizer Powder；
2, it extracting: taking elscholtiza fine powder 600g, using CO 2 fluid extraction equipment, extract volatile oil, extraction temperature is 40 DEG C, Extracting pressure is 8.5Mpa, and extraction time is 2.5 hours, obtains volatile oil 10.4ml, after measured, thymol (C10H14O) Content is 49.33%；Carvacrol (C10H14O content) is 14.49%.
The preparation of elscholtiza oil capsule
Each 10ml of volatile oil for taking above-described embodiment 1-6 to prepare adds ethyl alcohol 20ml, the volatile oil solution stirred evenly；Take beta-cyclodextrin 120g adds 360ml water to dissolve by heating, and above-mentioned volatile oil solution is slowly added under 40 DEG C of insulated and stirreds, insulated and stirred 5 minutes, is led to It crosses colloid mill to include 3 times, refrigeration 12 hours or more, filter, inclusion compound sets 40 DEG C of forced air dryings 6 hours, is sieved, and stearic acid is added Magnesium 0.4g is mixed, and is packed into capsule to get finished product.
Clinical case:
Chen, male, 11 years old.Vomiting 5 times was caused because food does not wash melon and fruit before 2 days, nausea, abdominal pain, defecating is dilute water just 3 times, nothing Mucus purulence blood.Stool routine examination microscopy WBC:11.85 × 109/ L has no RBC, and blood routine examination is without special discovery.In vomitus Detect norovirus.The elscholtiza oil capsule of the preparation of the embodiment of the present invention 1 is taken, 3 times a day, once a grain.After taking 1 day, Symptom is substantially reduced；After taking 2 days, restore normal completely, does not find any adverse reaction.
Mr. Wang, female, 5 years old.It p.prand vomits, abdominal pain, defecates for dilute water just.Through hospitalized to have a thorough examination, examined in vomitus Measure norovirus.The elscholtiza oil capsule of the preparation of the embodiment of the present invention 3 is taken, 3 times a day, once a grain.The treatment same day is at night After taking the 1st time, next day vomiting, colic symptoms disappear, and restore normal, do not find any adverse reaction.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.

Claims (7)

1. a kind of application of Herba Moslae volatile oil in treatment norovirus infectious diarrhea, which is characterized in that the elscholtiza is waved The total amount of thymol and carvacrol is no less than 60% in hair oil.
2. application according to claim 1, which is characterized in that the content of thymol is 48%- in Herba Moslae volatile oil 60%, the content of carvacrol is 12%-20%.
3. application according to claim 1 or 2, which is characterized in that the Herba Moslae volatile oil is used to elscholtiza fine powder Critical carbon dioxide fluid extraction obtains, and extraction temperature is 20~65 DEG C, and extracting pressure is 5~20Mpa, and extraction time is 1~4 Hour.
4. application according to claim 3, which is characterized in that the extraction temperature is 30~40 DEG C, extracting pressure 8 ~10Mpa, extraction time are 1.5~3 hours.
5. application according to claim 4, which is characterized in that the extraction temperature is 35~38 DEG C, and extracting pressure is 8.5~8.9Mpa, extraction time are 2~2.5 hours.
6. application according to claim 3, which is characterized in that the elscholtiza fine powder is after cleaning elscholtiza in 30~70 DEG C low temperature drying is crushed to obtained by 10~20 mesh.
7. according to application described in claim 1, which is characterized in that the Herba Moslae volatile oil is by being added each of pharmacy permission The capsule taken orally in pharmacy is made in kind auxiliary material.
CN201710770806.2A 2017-08-31 2017-08-31 Application of herba Moslae volatile oil in treating norovirus infectious diarrhea Active CN109419846B (en)

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