CN109418277A - Composition and its preparation and application containing zinc thiazole and fluorine thiazole pyrrole ethyl ketone - Google Patents
Composition and its preparation and application containing zinc thiazole and fluorine thiazole pyrrole ethyl ketone Download PDFInfo
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- CN109418277A CN109418277A CN201710716833.1A CN201710716833A CN109418277A CN 109418277 A CN109418277 A CN 109418277A CN 201710716833 A CN201710716833 A CN 201710716833A CN 109418277 A CN109418277 A CN 109418277A
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- ethyl ketone
- thiazole
- pyrrole ethyl
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/16—Heavy metals; Compounds thereof
Abstract
The invention discloses a kind of composition containing zinc thiazole and fluorine thiazole pyrrole ethyl ketone, the composition includes zinc thiazole and fluorine thiazole pyrrole ethyl ketone, wherein the weight ratio of the zinc thiazole and fluorine thiazole pyrrole ethyl ketone is 1: (0.01-100).In the presence of effective component zinc thiazole and fluorine thiazole pyrrole ethyl ketone are in the present composition with specified weight ratio, bactericidal activity effect is greater than the bactericidal activity summation of zinc thiazole and fluorine thiazole pyrrole ethyl ketone, syneryistic effect highly significant.
Description
Technical field
The invention belongs to technical field of pesticide, and in particular to composition and its preparation containing zinc thiazole and fluorine thiazole pyrrole ethyl ketone
And application.
Background technique
Various diseases caused by various bacteria, fungi etc. are infected often are encountered in the actual production of crops, are prevented
These diseases are controlled other than necessary agricultural measures, the use of fungicide are essential.However, in most cases, one
The activity of kind of fungicide is often due to the limitation of its fungicidal spectrum and disease caused by cannot effectively preventing various bacteria, fungi etc. simultaneously
Evil, and repeat and got worse in large quantities using the drug resistance that single bactericide will lead to germ.Therefore, it is sterilized to expand
The generation for composing, improving control efficiency, reducing dosage, delay drug resistance or drug resistance, carrying out compounding to fungicide is in solution
State the effective and practical approach of one kind of problem.
Zinc thiazole is thiadiazole organic zinc fungicide, is the compound that the applicant succeeded in developing in 1999
(ZL00132119.6), single dose largely enters market, serves agricultural.Zinc thiazole imitates the prevention and treatment of bacterial diseases of plants
Fruit is prominent, also has good preventive effect to some fungi disease, while when concentration is appropriate can promote the life of root system of plant and cauline leaf
It is long, improve resistance and disease resistance.In addition, the zinc thiazole also strong feature with high security and with other fungicide miscibilties.
Although zinc thiazole is considered as that effectively, cannot fully meet plant tolerance and sterilize the requirement of high activity, and act on
Target is relatively single, is easy to produce drug resistance, and so as to cause dosage increase, pesticide residue aggravation further promotes drug resistance
Development.
CN105941427A discloses a kind of bactericidal composition containing volution bacterium amine and zinc thiazole and its application.The sterilization group
Close object using volution bacterium amine and zinc thiazole as principle active component, wherein the mass ratio of volution bacterium amine and zinc thiazole be 1~90:1~
90.The bactericidal composition can be applied to prevention and treatment Cereal, fruit tree, vegetable disease, it is particularly possible to for prevent and treat powdery mildew, rust,
The fungal diseases such as stripe disease, bacterial blight of rice, bacterial stripe, anthracnose and bacteriosis.
Fluorine thiazole pyrrole ethyl ketone is a kind of new piperidine class fungicide, is the highest a kind of oomycetes suppression of bioactivity so far
Preparation and 21 century are most representative and be expected to new type bactericide as series of products, can significantly reinforce to potato,
The prevention and treatment of the specialties corps diseases such as grape, vegetables, and there is unique action site to Oomycete pathogen.Fluorine thiazole pyrrole second
Ketone also has very favorable toxicology and an environmental characteristics, and dosage is also few, to the safety of user, agricultural producer and environment compared with
It is high.Current many researchers are dedicated to researching and developing the composite bactericide containing fluorine thiazole pyrrole ethyl ketone: as 106234377 A of CN is disclosed
A kind of bactericidal composition of fluorine-containing thiazole pyrrole ethyl ketone and eugenol；106172435 A of CN discloses one kind and contains benzene thiophene bacterium
The bactericidal composition of ester and fluorine thiazole pyrrole ethyl ketone.
Different farm chemical ingredients are compounded, judge that agriculture chemical compounding is synergy, sums it up also by practical application effect
It is antagonism.In most cases, the effect of agriculture chemical compounding is addition, and the agriculture chemical compounding with synergistic effect is few
It is again few, the especially significant agriculture chemical compounding of synergistic effect is even more rare.So far, about zinc thiazole and fluorine thiazole pyrrole ethyl ketone
The composition of compounding and application there is no people to report at present.The present inventor carries out the recipe determination of zinc thiazole and fluorine thiazole pyrrole ethyl ketone
Further investigation, find zinc thiazole and fluorine thiazole pyrrole ethyl ketone carry out mixture the latter two in certain mixed ratio to prevention and treatment crop
Disease has unexpected control efficiency, and synergistic effect is fairly obvious.Based on this discovery, after further study, applicant is complete
At the present invention.
Summary of the invention
In view of the above problems, the present inventor is tested repeatedly in order to solve the problems, such as that single bactericide is also easy to produce drug resistance
After find, by zinc thiazole and fluorine thiazole pyrrole ethyl ketone compounding can effectively prevent disease, have significant synergies, to cause
Reduce formulation rate, so that cost also reduces.Particularly, the mechanism of action of zinc thiazole and fluorine thiazole pyrrole ethyl ketone is not identical, can
Delay the generation of pathogen resistance.
To achieve the goals above, present invention firstly provides a kind of composition containing zinc thiazole and fluorine thiazole pyrrole ethyl ketone, institute
Stating composition includes zinc thiazole and fluorine thiazole pyrrole ethyl ketone, wherein the weight ratio of the zinc thiazole and fluorine thiazole pyrrole ethyl ketone is 1:
(0.01-100).In the presence of effective component zinc thiazole and fluorine thiazole pyrrole ethyl ketone are in the present composition with specified weight ratio, sterilization
Active function is greater than the bactericidal activity summation of zinc thiazole and fluorine thiazole pyrrole ethyl ketone, syneryistic effect highly significant.
Preferably, in above-mentioned composition, the weight ratio of the zinc thiazole and fluorine thiazole pyrrole ethyl ketone is 1: (0.02-50).
It is highly preferred that the weight ratio of the zinc thiazole and fluorine thiazole pyrrole ethyl ketone is 1: (0.05- in above-mentioned composition
30)。
Most preferably, in above-mentioned composition, the weight ratio of the zinc thiazole and fluorine thiazole pyrrole ethyl ketone is 1: (1-10).
Preferably, in above-mentioned composition, the composition also includes insecticides adjuvant, wherein the zinc thiazole and fluorine thiazole
The sum of weight of pyrrole ethyl ketone is the 1%-90%, preferably 5%-80%, more preferably 10%- of the composition total weight
60%, remaining is insecticides adjuvant.
The insecticides adjuvant be all in preparing commonly use or agriculturally allow using various composition, be not particularly limited, have
Body ingredient and dosage are determined as desired by test.
Compared with bactericidal composition of the present invention is used alone with zinc thiazole and fluorine thiazole pyrrole ethyl ketone, there is apparent synergy to make
With, and protective effect is obvious, the decline of total dosage, greatly reduces dispenser cost, while more on unit area
On delay the generation of pathogen drug resistance, reduce the risk that pathogen generates resistance to single bactericide, extend composition
The service life of middle each component, to realize the purpose of economical and efficient.
Preferably, in above-mentioned composition, the insecticides adjuvant includes wetting agent, dispersing agent, emulsifier, helps surface-active
Agent, thickener, solvent, cosolvent, antifreezing agent, disintegrating agent, effervesce auxiliary agent, preservative, stabilizer, film forming agent, encapsulating agent, pH acid
One of alkali regulator, defoaming agent, colorant, filler, water etc. are a variety of, and the insecticides adjuvant is all common or agriculture in preparing
Allow in industry using various composition, be not particularly limited, specific ingredient and dosage are determined as desired by test.
Preferably, in above-mentioned composition, the wetting agent is selected from EO/PO block polyether, fatty alcohol polyoxyethylene ether, rouge
Fat alcohol ethoxylates, shea butter ethyoxyl ammonium salt, alkylnaphthalene sulfonate, fatty alcohol polyoxyethylene ether sulfate, acyl group paddy
One of amino acid salt is a variety of.
Preferably, in above-mentioned composition, the dispersing agent be selected from condensation naphthalene sulfonate, phenolsulfonic acid condensation product sodium salt,
Methyl naphthalene sulfonate formaldehyde condensate, sodium lignin sulfonate, sodium metnylene bis-naphthalene sulfonate, acrylate homopolymer sodium salt, macromolecule
One of polycarboxylate, dioctyl sodium sulphosuccinate salt, EO/PO block polyether, maleic acid-acrylic acid copolymer sodium salt or
It is a variety of.
Preferably, in above-mentioned composition, the emulsifier is selected from alkyl phenol polyoxyethylene ether, benzyl phenol polyethenoxy
Ether, phenethyl phenol polyethenoxy ether, fatty alcohol polyoxyethylene ether, phenethyl phenol polyethenoxy ether polyethenoxy ether, fatty amine are poly-
Ethylene oxide ether, castor oil ethylene oxide adduct and its derivative, polyol fatty acid ester and its ethylene oxide adduct, alkyl
Benzene sulfonate, alkylsulfonate, dialkyl succinylsuccinate sulfonated ester, alkyl biphenyl base ether sulfonate, naphthalene sulfonic acid-formaldehyde condensation product, rouge
Fat alcohol sulfate, alkyl phenol polyoxyethylene ether sulfate, aralkyl phenol polyethenoxy ether sulfate, alkyl phenol polyoxyethylene ether phosphorus
Acid esters, phenethyl phenol polyethenoxy ether phosphate, polyoxyethylene carboxylate phosphate, ethoxylated fatty amines phosphate,
Alkylphosphonic, APES formaldehyde condensation product, aralkyl phenol polyethenoxy ether formaldehyde condensation products, xenol polyoxy
Vinethene formaldehyde condensation products, polyoxyethylene polyoxypropylene block copolymer, alkyl naphthalene sulfonic acid formaldehyde condensation products, phenol formaldehyde condensate
Sulfonate, APES formaldehyde condensation products sulfat, contracting methylcellulose and its derivative, alkylammonium salt, amino
Polyol fatty acid derivative, polyamines derivative of fatty acid, quaternary ammonium salt, shea butter ethyoxyl ammonium salt, alkylnaphthalene sulfonate, amino acid,
One of amine oxide, glycine betaine, fatty alcohol polyoxyethylene ether sulfate and acyl group glutamate are a variety of.
Preferably, in above-mentioned composition, the cosurfactant is selected from n-butanol, isobutanol, n-octyl alcohol, isopropanol
One of or it is a variety of.
Preferably, in above-mentioned composition, the thickener is selected from xanthan gum, aluminum magnesium silicate, sodium carboxymethylcellulose, shallow lake
One of powder sodium phosphate, starch Sodium Octenyl Succinate, polyvinyl alcohol are a variety of.
Preferably, in above-mentioned composition, the solvent is selected from dimethylbenzene, turpentine-based vegetable oil, methyl oleate and weight virtue
One of hydrocarbon solvent oil is a variety of.
Preferably, in above-mentioned composition, the cosolvent is selected from cyclohexanone, n,N-dimethylacetamide, N, N- diformazan
One of base formamide is a variety of.
Preferably, in above-mentioned composition, the antifreezing agent be selected from ethylene glycol, propylene glycol, glycerine, isopropanol, urea,
One of diethylene glycol is a variety of.
Preferably, in above-mentioned composition, the film forming agent selects polyvinyl alcohol, polyvinyl acetate, polyethylene second two
Alcohol polymethylacrylic acid glycol ester, carboxymethyl cellulose, gum arabic, xanthan gum, starch etc. have caking property and film forming
The high molecular polymer of property.
Preferably, in above-mentioned composition, cyst material used in the encapsulating agent is that carbamide resin is by isocyanates list
Body and polyalcohol or polyamine are made by interface polymerization reaction, and wherein isocyanates is selected from toluene di-isocyanate(TDI), 4,
The multiple methylene polyisocyanates of 4- methyl diphenylene diisocyanate, more phenyl, polyphenyl polymethylene polyisocyanates etc..
Preferably, in above-mentioned composition, the pH acid-base modifier is selected from citric acid, glacial acetic acid, hydrochloric acid, ammonium hydroxide, three
One of ethamine, triethanolamine and diethylenetriamine are a variety of；Institute's expense is that the pH value of final products is adjusted to stabilization
It is advisable in range.
Preferably, in above-mentioned composition, the disintegrating agent is selected from sodium chloride, ammonium chloride, ammonium sulfate, sodium sulphate, solvable
One of property starch is a variety of.
Preferably, in above-mentioned composition, the effervesce auxiliary agent is selected from citric acid, tartaric acid, adipic acid, fumaric acid, apple
Tartaric acid, potassium citrate dihydrogen, tartaric acid potassium dihydrogen, succinic acid, sodium carbonate, ammonium carbonate, sodium bicarbonate, calcium carbonate, potassium carbonate, carbon
One of potassium hydrogen phthalate is a variety of.
Preferably, in above-mentioned composition, the preservative is selected from Kathon CG, 2- benzisothiazole-3-ketone, formaldehyde, water
One of poplar acid phenenyl ester, sodium benzoate, butyl p-hydroxybenzoate, potassium sorbate are a variety of.
Preferably, in above-mentioned composition, the stabilizer is selected from epoxidized soybean oil, epoxychloropropane, phosphorous triphenyl phosphate
Ester, glycidol ether and/or pentaerythrite.
Preferably, in above-mentioned composition, the defoaming agent is selected from organic silicon defoamer and/or polyether antifoam agent.
Preferably, in above-mentioned composition, the colorant be selected from one of iron oxide, titanium oxide, azo dyes or
It is a variety of.
Preferably, in above-mentioned composition, the filler is selected from kaolin, diatomite, talcum powder, precipitated calcium carbonate, white
One of carbon black is a variety of.
Preferably, in above-mentioned composition, the water be tap water, deionized water, distilled water or other meet agricultural and want
That asks uses water.
The present composition can be prepared into agriculturally acceptable solid-like or liquid preparation.This kind of composition can
It is prepared by known method by mixed active ingredient zinc thiazole and fluorine thiazole pyrrole ethyl ketone with suitable auxiliary element, wherein solid
Shape preparation includes the wettable powder of powdery, pulvis, seed treatment dry powder doses, seed treatment dispersible pulvis, granule, does and hang
Floating agent, water dispersible granules, soluble granule, effervescent tablet or granulae effervescentes, liquid preparation include suspending agent, suspoemulsion, micro-capsule
Suspending agent, dispersible oil-suspending agent, seed treatment suspending agent, seed treatment microcapsule suspending agent, suspension seed-coating agent.
So the dosage form of above-mentioned composition can be suspending agent, suspoemulsion, microcapsule suspending agent, seed treatment suspending agent, seed
Handle microcapsule suspending agent, suspension seed-coating agent, dispersible oil-suspending agent, wettable powder, pulvis, seed treatment dry powder doses, seed
Handle dispersible pulvis, water dispersible granules, granule, dry suspending agent, soluble granule, effervescent tablet and/or granulae effervescentes.
The processing technology of the various dosage forms of the present composition, adopts equipment by known method, is Pesticide formulation technique
In common method.
Product of the present invention can be provided in the form of finished product preparation, i.e., each substance has mixed in composition, be made
Used time is directly diluted to required concentration；The ingredient of composition can also be provided in the form of single dose, directly be existed using preceding
It is directly mixed in bucket and tank by metering, is then diluted to required concentration.
In addition, being applied to the purposes of prevention and treatment corps diseases the present invention also provides the purposes of above-mentioned composition.
Preferably, the crops are cucumber, grape, potato, capsicum, Chinese cabbage and citrus.
Preferably, the disease is fungal disease and/or bacterial disease.
It is highly preferred that the fungal disease is cucumber downy mildew, downy mildew of garpe, the late blight of potato, capsicum epidemic disease
In it is one or more, the bacterial disease is that soft rot of cabbage, cucumber bacterial angular leaf spot, citrus bacterial canker disease, potato are black
One of shin disease is a variety of.
The method that product of the present invention uses includes being applied to plant to be processed or its growth place, seed, material with mixing
It, can be in germ, virus, pestinfestation material, plant with the zinc thiazole and fluorine thiazole pyrrole ethyl ketone active compound of total effective dose
Or it is applied before or after seed.
Terms used herein " growth place " includes growth process plant or the field for sowing cultivated plant seed, or kind
Son is embedded in the place in soil.Term " seed " includes all plant propagation materials such as nursery stock, fruit, seed, stock, connects
Fringe, cutting, sprout, root tuber, stem tuber, bulb, bulb, pollen or plant culture materials.
Composition and its preparation of the present invention can be used with itself concentration form or with dosage form, according to
The property difference use of target disease is sprayed, spray, pouring, atomizing, seed dressing, soaks seed, spreading fertilizer over the fields or brushing method, application always have
Active bactericidal amount is imitated to change with weather condition, crop condition or method of administration.
In addition, the effective component zinc thiazole in product of the present invention contains Zn-ef ficiency, not only there is bactericidal effect, it can be with
Microelement-supplementing improves crop anti-adversity and disease resistance so that plant be promoted to grow.
Compared with prior art, the present invention has the following advantages and beneficial effects:
1) synergistic effect is significant: zinc thiazole and fluorine thiazole pyrrole ethyl ketone show significant collaboration in certain ratio range
Effect has the control efficiency significantly improved to disease compared to single dose, reduces the usage amount and dispenser cost of pesticide；
2) use cost reduces: since zinc thiazole and fluorine thiazole pyrrole ethyl ketone have significant synergistic function and obviously mention
High protection effect, reduces spraying times, and therefore reduces use cost, time and labour saving, have apparent economic benefit and
Social benefit；
3) generation of resistance delays: effective component zinc thiazole and fluorine thiazole pyrrole ethyl ketone of the invention has the function of different machines
System and fungicidal spectrum, bactericidal effect is good, and significantly reduces the dosage of single medicament, is conducive to delay pathogen resistance
It generates, and expands the use scope and service life of product of the present invention；
4) environmental pollution is reduced: since zinc thiazole and fluorine thiazole pyrrole ethyl ketone have excellent synergistic effect and protection effect,
Anti- pathogen, antibacterial or antibacterial effect are not only increased, prevention spectrum has also been enlarged, so as to reduce times for spraying, simultaneously
Administration dosage is significantly reduced, therefore reduces environmental pollution and increases the safety to people and animals simultaneously.
Specific embodiment
In order to keep objects and advantages of the present invention more concise, the present invention will be explained with following specific embodiments
Bright, however, the present invention is by no means limited to these examples.Following embodiment is only the present invention more preferably embodiment, and is only used for explaining
The present invention is stated, should not be understood as limitation of the scope of the invention.It should be pointed out that all within essence and principle of the invention
Any modifications, equivalent replacements, and improvements etc. done, should all be included in the protection scope of the present invention.Therefore, the present invention is special
The scope of protection shall be subject to the appended claims for benefit.
Unless otherwise mentioned, each component used herein is commercially available or well-known in the prior art or skill
Art personnel are readily available by the disclosure of the prior art.
Example of formulations
Following term illustrates in the embodiment of the present invention that Fungicidal compounds zinc thiazole and fluorine azoles Acibenzolar are with specific mixture
The composition of composition of proportions.
Embodiment 1:40% zinc thiazole fluorine thiazole pyrrole ethyl ketone (35.0%+5.0%) suspending agent
By 35.0g zinc thiazole, 5.0g fluorine thiazole pyrrole ethyl ketone, 2.0g fatty alcohol polyoxyethylene ether, 2.0g alkylnaphthalene sulfonate,
1.0g methyl naphthalene sulfonate formaldehyde condensate, 0.1g gum arabic, 0.5g aluminum magnesium silicate, 2.0g glycerine, 0.6g benzoic acid
Sodium, 0.1g organic silicon defoamer, deionized water are mended to 100g, are put into high shear homogeneous emulsifying machine high speed and are sheared 20 minutes,
It transports in sand mill again, circulation is sanded 3 times up to suspending agent.
Embodiment 2:45% zinc thiazole fluorine thiazole pyrrole ethyl ketone (40.0%+5.0%) suspending agent
By 40.0g zinc thiazole, 5.0g fluorine thiazole pyrrole ethyl ketone, 2.5g alkylnaphthalene sulfonate, 1.0g fatty alcohol polyoxyethylene ether
Sulfate, 3.5g sodium lignin sulfonate, 2.0g starch Sodium Octenyl Succinate, 2.5g glycerine, 0.2g potassium sorbate, 0.1g are poly-
Ether defoaming agent, distilled water are mended to 100g, are put into high shear homogeneous emulsifying machine high speed and are sheared 25 minutes, then pump into sand mill
It is sanded 90 minutes, up to suspending agent after filtering.
Embodiment 3:50% zinc thiazole fluorine thiazole pyrrole ethyl ketone (10.0%+40.0%) suspending agent
By 10.0g zinc thiazole, 40.0g fluorine thiazole pyrrole ethyl ketone, 1.0g shea butter ethyoxyl amine salt, 2.5g acyl group Glutamic Acid
Salt, 3.0g dioctyl sodium sulphosuccinate salt, 3.0g urea, 0.1g polyether antifoam agent, deionized water are mended to 100g, and height is put into
Shear homogeneous emulsifying machine high speed shear 20 minutes, then with after high pressure homogenizer homogeneous to obtain the final product 50% suspending agent.
Embodiment 4:50% zinc thiazole fluorine thiazole pyrrole ethyl ketone (25.0%+25.0%) suspending agent
By 25.0g zinc thiazole, 25.0g fluorine thiazole pyrrole ethyl ketone, 1.0g EO/PO block polyether, 2.4g alkylnaphthalene sulfonate,
4.5g polymeric polycarboxylic acid salt, 1.5g acrylate homopolymer sodium salt, 2.0g ethylene glycol, 0.1g organic silicon defoamer, 0.5g Kathon CG,
Tap water is mended to 100g, is put into high shear homogeneous emulsifying machine high speed and is sheared 30 minutes, then transport in sand mill, circulation is sanded
3 times up to 50% suspending agent.
Embodiment 5:25% zinc thiazole fluorine thiazole pyrrole ethyl ketone (10.0%+15.0%) microcapsule suspending agent
By 10.0g zinc thiazole, 15.0g fluorine thiazole pyrrole ethyl ketone, 1.0g EO/PO block polyether, 1.5g phenolsulfonic acid condensation product
Sodium salt, 0.15g organic silicon defoamer, two isocyanide of 3.4g polyphenyl polymethylene polyisocyanates PAPI, 2.5g diphenyl methane
Acid esters MDI, 10g Arabic gum aqueous solution (mass fraction of Arabic gum is 5%) and 39.0g deionized water are sufficiently mixed,
It puts into sand mill and is sanded again, be sanded to D90Partial size is 4 microns.Later on stirring (maintaining 700 turns/min), and will be sanded
Good suspension is warming up to 60 DEG C, while being slowly added to 0.05g triethanolamine, maintains stable cyst material solidification temperature 8 small
When, 2g fatty alcohol polyoxyethylene ether sulfate, 1.6g phenolsulfonic acid condensation product sodium salt, 2.2g urea, 2.2g the third three are added later
Alcohol, 9.0g sodium carboxymethyl cellulose solution (its mass fraction is 2.5%), suitable diluted hydrochloric acid aqueous solution tune pH value to 6.5
Left and right, 0.1g preservative formaldehyde and 0.3g organic silicon defoamer, stir evenly, obtain 25% microcapsule suspending agent.
Embodiment 6:60% zinc thiazole fluorine thiazole pyrrole ethyl ketone (15.0%+45.0%) water dispersible granules
By 15.0g zinc thiazole, 45.0g fluorine thiazole pyrrole ethyl ketone, 5.0g fatty alcohol polyoxyethylene ether, 4.0g lignin sulfonic acid
Salt, 15.0g sodium sulphate, 2.0g aluminum magnesium silicate, kaolin are mended to 100g, are sufficiently mixed, then by air-flow crushing, granulating and forming is obtained
Water dispersible granules.
Embodiment 7:50% zinc thiazole fluorine thiazole pyrrole ethyl ketone (20.0%+30.0%) water dispersible granules
By 20.0g zinc thiazole, 30.0g fluorine thiazole pyrrole ethyl ketone, 6.0g EO/PO block polyether, 5.0g aliphatic alcohol polyethenoxy
Ether, 5.0g sodium sulphate, 1.5g starch Sodium Octenyl Succinate, diatomite are mended to 100g and are sufficiently mixed, and it is mixed that tap water is then added
It closes uniformly, and puts into high shear homogeneous emulsifying machine high speed shearing corase grinding and homogeneous, then pump and be sanded into sand mill, later
Granulating and forming obtains water dispersible granules.
Embodiment 8:60% zinc thiazole fluorine thiazole pyrrole ethyl ketone (40.0%+20.0%) water dispersible granules
By 40.0g zinc thiazole, 20.0g fluorine thiazole pyrrole ethyl ketone, 4.5g EO/PO block polyether, 6.5g aliphatic alcohol polyethenoxy
Ether, 2g lignosulfonates, 10.0g sodium chloride, 2.0g starch Sodium Octenyl Succinate, kaolin are mended to 100g and are sufficiently mixed,
Then be added distilled water be uniformly mixed, and put into high shear homogeneous emulsifying machine high speed shearing corase grinding and homogeneous, then pump to
It is sanded in sand mill, granulating and forming obtains water dispersible granules later.
Embodiment 9:35% zinc thiazole fluorine thiazole pyrrole ethyl ketone (25.0%+10.0%) effervescent tablet
By 25.0g zinc thiazole and 10.0g fluorine thiazole pyrrole ethyl ketone, potassium citrate dihydrogen 5.0g, starch 10.0g, poly-vinegar acid second
Enester 3.0g, fatty alcohol polyoxyethylene ether sulfate 2.8.0g, alkylnaphthalene sulfonate 3.2g, sodium carbonate 10.0g, white carbon black
15.0g, diatomite are mended to 100g, are mixed merga pass ultra-fine grinding, then are granulated, it is dry after again tabletting to get 35% effervescent tablet.
Embodiment 10:60% zinc thiazole fluorine thiazole pyrrole ethyl ketone (50.0%+10.0%) wettable powder
By 50.0g zinc thiazole, 10.0g fluorine thiazole pyrrole ethyl ketone, 3.0g maleic acid-acrylic acid copolymer sodium salt, 4.5g high score
Sub- polycarboxylate, 2.0g talcum powder, 5.0g precipitated calcium carbonate, diatomite are mended to 100g and are sufficiently mixed, and ultra-fine grinding is then carried out
Up to wettable powder.
Embodiment 11:18% zinc thiazole fluorine thiazole pyrrole ethyl ketone (16.0%+2.0%) dry suspending agent
By 16.0g zinc thiazole and 2.0g fluorine thiazole pyrrole ethyl ketone, 6.0g lignosulfonates, 4.0g alkylnaphthalene sulfonate,
0.1g xanthan gum, 16.0g white carbon black, 4.0g potassium carbonate, diatomite are mended to 100g, are sufficiently mixed, then plus it is a certain proportion of originally
Water puts into high shear emulsifying kettle high speed shearing corase grinding and homogeneous, then pumps and be sanded into sand mill, is sanded to certain grain
Diameter, then granulating and forming obtain 18% dry suspending agent.
Embodiment 12:30% zinc thiazole fluorine thiazole pyrrole ethyl ketone (20.0%+10.0%) suspension seed-coating agent
By 20.0g zinc thiazole, 10.0g fluorine thiazole pyrrole ethyl ketone, 2.0g alkylnaphthalene sulfonate, 5.0g acyl group sodium hydrogen α-aminoglutarate,
2.5g dioctyl sodium sulphosuccinate salt, 2.0g gum arabic, 3.0g isopropanol, 0.2g xanthan gum, 0.3g Kathon CG, 0.6g oxygen
Change titanium, 0.1g polyether antifoam agent, distilled water is mended to 100g and is sufficiently mixed, puts into high shear homogeneous emulsifying machine high speed later and cut
Corase grinding and homogeneous are cut, and pumps and is sanded into sand mill, is then filtered up to suspension seed-coating agent.
Embodiment 13:50% zinc thiazole fluorine thiazole pyrrole ethyl ketone (20.0%+30.0%) granule
By 20.0g zinc thiazole, 30.0g fluorine thiazole pyrrole ethyl ketone, 4.0gEO/PO block polyether, 5.0g ammonium sulfate, 2.0g hard charcoal
Black, 10.0g ammonium chloride, diatomite are mended to 98g, are sufficiently mixed, and by air-flow crushing, add 2.0g carboxymethyl cellulose,
Middle carboxymethyl cellulose is configured to aqueous solution with the water for accounting for dry weight 30% in advance, after mixing mixed at high speed granulating and forming, dries
50% granule is obtained after dry, screening qualification.
Embodiment 14:50% zinc thiazole fluorine thiazole pyrrole ethyl ketone (25.0%+25.0%) seed treatment dry powder doses
25.0g zinc thiazole and 25.0g fluorine thiazole pyrrole ethyl ketone, 4.5g condensation naphthalene sulfonate, 2.5g talcum powder, 14.5g is light
Matter calcium carbonate, diatomite are mended to 100g and are sufficiently mixed, and carry out ultra-fine grinding later up to seed treatment dry powder doses.
Embodiment 15:45% zinc thiazole fluorine thiazole pyrrole ethyl ketone (30.0%+15.0%) seed treatment suspending agent
By 30.0g zinc thiazole, 15.0g fluorine thiazole pyrrole ethyl ketone, 2.0g shea butter ethyoxyl ammonium salt, 1.5g acyl group Glutamic Acid
Salt, 1.0g fatty alcohol polyoxyethylene ether sulfate, 1.0g acrylate homopolymer sodium salt, 2.0g starch Sodium Octenyl Succinate,
2.0g polyethylene glycol polymethylacrylic acid glycol ester, 1.0g pentaerythrite, 2.0g glycerine, the defoaming of 0.1g organosilicon
Agent, deionized water are mended to 100g and are uniformly mixed, and are put into high shear homogeneous emulsifying machine high speed and sheared 25 minutes, are then pumped extremely
It is sanded 60 minutes, filters later up to 45% seed treatment suspending agent in sand mill.
Embodiment 16:35% zinc thiazole fluorine thiazole pyrrole ethyl ketone (30.0%+5.0%) seed treatment microcapsule suspending agent
50.0g zinc thiazole, 2.0g polymeric polycarboxylic acid salt, 2.0g polyether antifoam agent and 46g deionized water are sufficiently mixed,
It puts into sand mill and is sanded again, filtered later up to 50.0% thiazole zincium suspension agent.Then it is prepared 60.0g is above-mentioned
50% thiazole zincium suspension agent, 5.0g fluorine thiazole pyrrole ethyl ketone, 1.0g alkylnaphthalene sulfonate, 2.0g acyl group glutamate, 1.0g fat
Alcohol polyoxyethylene ether sulfate, 1.0g starch Sodium Octenyl Succinate, 2.0g glycerine, deionized water are mended to 100g and are mixed
It closes, and puts into high shear homogeneous emulsifying machine and be warming up to 70 DEG C, emulsifying rate is 1200 revs/min, high speed shear 25 minutes, warm
Bath 120 minutes, up to 35% seed treatment microcapsule suspending agent after filtering.
Oil-suspending agent can be dispersed in embodiment 17:25% zinc thiazole fluorine thiazole pyrrole ethyl ketone (20.0%+5.0%)
By 20.0g zinc thiazole, 5.0g fluorine thiazole pyrrole ethyl ketone, 4.0g fatty alcohol polyoxyethylene ether, 4.0g alkylnaphthalene sulfonate,
0.3g aluminum magnesium silicate, 2.0g ethylene glycol, 0.5g Kathon CG, 0.2g organic silicon defoamer, methyl oleate are mended to 100g, are put into height and are cut
It cuts homogeneous emulsifying machine high speed to shear 20 minutes, then pumps into sand mill, circulation is sanded after 3 filterings up to 25% dispersible oil
Suspending agent.
The invention will be further described with reference to embodiments, and the preparation method of dosage form is conventional side in embodiment
Method, " % " of the present invention is mass percent.
Field control effectiveness test
Test process: be respectively adopted 15mg/L, 25mg/L, 75mg/L, 100mg/L, 500mg/L, 800mg/L and
20% thiazole zincium suspension agent of 1000mg/L and 10% fluorine of 10mg/L, 40mg/L, 100mg/L, 750mg/L and 1500mg/L
Thiazole pyrrole ethyl ketone suspending agent, 12 kinds of single doses；And the combined medicament of above 12 kinds of single doses, to potato, Chinese cabbage and cucumber into
Row field trial.Test period is 2015-2016, and prevention and treatment cucumber downy mildew is referring to " National Standard of the People's Republic of China GB/
T17980.26-2000 " carry out field control effectiveness test；Soft rot of cabbage is prevented and treated referring to " National Standard of the People's Republic of China GB/
T17980.114-2004 " carry out field control effectiveness test；Cucumber bacterial angular leaf spot is prevented and treated referring to " country, the People's Republic of China (PRC)
Standard GB/T17980.110-2004 " carry out field control effectiveness test；The late blight of potato is prevented and treated referring to " state, the People's Republic of China (PRC)
Family standard GB/T17980.34-2000 " carry out field control effectiveness test.
2. preventive effect is evaluated:
According to Gowing method evaluating drug effect mode, calculation formula are as follows: E0=X+Y (100-X)/100, wherein X is anti-for A single dose
It imitates (%), Y is B single dose preventive effect (%), and the practical preventive effect (%) that E A, B twos' single dose are mutually mixed works as E-E0It is synergistic effect when > 10,
E-E0It is acted on when < -10 for reduction, E-E0It is summation action when between ± 10.
The control efficiency of 1 zinc thiazole of table and fluorine thiazole pyrrole ethyl ketone and its mixture to cucumber downy mildew
The control efficiency of 2 zinc thiazole of table and fluorine thiazole pyrrole ethyl ketone and its mixture to soft rot of cabbage
The control efficiency of 3 zinc thiazole of table and fluorine thiazole pyrrole ethyl ketone and its mixture to cucumber bacterial angular leaf spot
The control efficiency of 4 zinc thiazole of table and fluorine thiazole pyrrole ethyl ketone and its mixture to the late blight of potato
The above result shows that: zinc thiazole and fluorine thiazole pyrrole ethyl ketone are compounded in the scope of the present invention ratio, to prevention and treatment
Cucumber downy mildew, cucumber bacterial angular leaf spot, the late blight of potato, soft rot of cabbage show preferable synergistic effect.
In summary, it is recommended to use the binary bactericidal composition of zinc thiazole and fluorine thiazole pyrrole ethyl ketone of the present invention is conducive to
Increase drug effect mutually, has no antagonism, and expand fungicidal spectrum, solve the problems, such as that plant develops drug resistance, agriculture can be substantially reduced
The use cost at family, simultaneously because reducing dosage and environmental pressure can be reduced.
According to the disclosure and teachings of the above specification, those skilled in the art in the invention can also be to above-described embodiment
It changes and modifies.Therefore, the invention is not limited to specific embodiments disclosed and described above, repair to some of invention
Change and change should also be as falling into the scope of the claims of the present invention.In addition, although having been used in this specification some
Specific term, these terms are merely for convenience of description, does not limit the present invention in any way.
Claims (9)
1. a kind of composition containing zinc thiazole and fluorine thiazole pyrrole ethyl ketone, which is characterized in that the composition includes zinc thiazole and fluorine
Thiazole pyrrole ethyl ketone, wherein the weight ratio of the zinc thiazole and fluorine thiazole pyrrole ethyl ketone is 1: (0.01-100).
2. composition according to claim 1, which is characterized in that the weight ratio of the zinc thiazole and fluorine thiazole pyrrole ethyl ketone is
1: (0.02-50), preferably 1: (0.05-30), more preferable 1: (1-10).
3. composition according to claim 1, which is characterized in that the composition also includes insecticides adjuvant, wherein described
The sum of weight of zinc thiazole and fluorine thiazole pyrrole ethyl ketone is the 1%-90% of the composition total weight, remaining is insecticides adjuvant.
4. composition according to claim 3, which is characterized in that the insecticides adjuvant includes wetting agent, dispersing agent, emulsification
Agent, cosurfactant, thickener, solvent, cosolvent, antifreezing agent, disintegrating agent, effervesce auxiliary agent, preservative, stabilizer, film forming
One of agent, encapsulating agent, pH acid-base modifier, defoaming agent, colorant, filler, water are a variety of.
5. composition described in any one of -4 according to claim 1, which is characterized in that the dosage form of the composition is to suspend
Agent, suspoemulsion, microcapsule suspending agent, seed treatment suspending agent, seed treatment microcapsule suspending agent, suspension seed-coating agent, dispersible oil are outstanding
Floating agent, pulvis, seed treatment dry powder doses, seed treatment dispersible pulvis, water dispersible granules, granule, is done and is hanged wettable powder
Floating agent, soluble granule, effervescent tablet and/or granulae effervescentes.
6. the purposes of any one of -4 compositions according to claim 1, which is characterized in that the purposes is for preventing and treating farming
Object disease.
7. purposes according to claim 6, which is characterized in that the crops are cucumber, grape, potato, capsicum, white
Dish and citrus.
8. purposes according to claim 6, which is characterized in that the disease is fungal disease and/or bacterial disease.
9. purposes according to claim 8, which is characterized in that the fungal disease is cucumber downy mildew, grape downy mildew
Disease, the late blight of potato, one or more in capsicum epidemic disease, the bacterial disease is soft rot of cabbage, the bacillary angle of cucumber
One of pinta, citrus bacterial canker disease, blakleg of potato are a variety of.
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| CN106719710A (en) * | 2017-01-20 | 2017-05-31 | 广东中迅农科股份有限公司 | A kind of bactericidal composition containing fluorine thiazole pyrrole ethyl ketone |
| CN106922707A (en) * | 2015-12-29 | 2017-07-07 | 浙江新农化工股份有限公司 | Bactericidal composition and its preparation and application containing picarbutrazox |
| CN108522519A (en) * | 2017-03-02 | 2018-09-14 | 江苏龙灯化学有限公司 | A kind of bactericidal composition |
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| CN101953346A (en) * | 2010-09-15 | 2011-01-26 | 浙江新农化工股份有限公司 | Zinc thiazole-containing bactericidal composition |
| CN104336033A (en) * | 2013-08-01 | 2015-02-11 | 陕西美邦农药有限公司 | A compound sterilization composition containing oxathiapiprolin and thiocarbamate |
| CN104396970A (en) * | 2014-11-11 | 2015-03-11 | 浙江新农化工股份有限公司 | Sterilizing composition containing zinc thiazole, preparation and applications thereof |
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