CN109122700A - Composition and its preparation and application containing zinc thiazole and azoles mepanipyrim - Google Patents
Composition and its preparation and application containing zinc thiazole and azoles mepanipyrim Download PDFInfo
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- CN109122700A CN109122700A CN201710456212.4A CN201710456212A CN109122700A CN 109122700 A CN109122700 A CN 109122700A CN 201710456212 A CN201710456212 A CN 201710456212A CN 109122700 A CN109122700 A CN 109122700A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/82—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with three ring hetero atoms
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
- A01G13/00—Protecting plants
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
- A01G7/00—Botany in general
- A01G7/06—Treatment of growing trees or plants, e.g. for preventing decay of wood, for tingeing flowers or wood, for prolonging the life of plants
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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Abstract
The invention discloses a kind of composition containing zinc thiazole and azoles mepanipyrim, the composition includes zinc thiazole and azoles mepanipyrim, wherein the weight ratio of the zinc thiazole and azoles mepanipyrim is 1: (0.01-50).In the presence of effective component zinc thiazole and azoles mepanipyrim are in the present composition with specified weight ratio, bactericidal activity effect is greater than the bactericidal activity summation of zinc thiazole and azoles mepanipyrim, syneryistic effect highly significant.
Description
Technical field
The invention belongs to technical field of pesticide, and in particular to composition and its preparation containing zinc thiazole and azoles mepanipyrim and answer
With.
Background technique
Various diseases caused by various bacteria, fungi etc. are infected often are encountered in the actual production of crops, are prevented
These diseases are controlled other than necessary agricultural measures, the use of fungicide are essential.However, in most cases, one
The activity of kind of fungicide is often due to the limitation of its fungicidal spectrum and disease caused by cannot effectively preventing various bacteria, fungi etc. simultaneously
Evil, and repeat and got worse in large quantities using the drug resistance that single bactericide will lead to germ.Therefore, it is sterilized to expand
The generation for composing, improving control efficiency, reducing dosage, delay drug resistance or drug resistance, carrying out compounding to fungicide is in solution
State the effective and practical approach of one kind of problem.
Zinc thiazole is thiadiazole organic zinc fungicide, is the compound that the applicant succeeded in developing in 1999
(ZL00132119.6), single dose largely enters market, serves agricultural.Zinc thiazole imitates the prevention and treatment of bacterial diseases of plants
Fruit is prominent, also has good preventive effect to some fungi disease, while when concentration is appropriate can promote the life of root system of plant and cauline leaf
It is long, improve resistance and disease resistance.In addition, the zinc thiazole also strong feature with high security and with other fungicide miscibilties.
Although zinc thiazole is considered as that effectively, cannot fully meet plant tolerance and sterilize the requirement of high activity, and act on
Target is relatively single, is easy to produce drug resistance, and so as to cause dosage increase, pesticide residue aggravation further promotes drug resistance
Development.Less as the research of bactericidal composition for zinc thiazole in the prior art, CN105941427A discloses one kind and contains
The bactericidal composition and its application of volution bacterium amine and zinc thiazole.The bactericidal composition is main effective with volution bacterium amine and zinc thiazole
Ingredient, wherein the mass ratio of volution bacterium amine and zinc thiazole is 1~90:1~90.The bactericidal composition can be applied to prevention and treatment cereal
Class, fruit tree, vegetable disease, it is particularly possible to for preventing and treating powdery mildew, rust, stripe disease, bacterial blight of rice, bacterial stripe
The fungal diseases such as disease, anthracnose and bacteriosis.
Azoles mepanipyrim is that triazole is phonetic its chemical name is 5- ethyl -6- heptyl [1,2,4] triazole [1,5] pyrimidine -7- amine
Pyridine class fungicide, belongs to mitochondrial respiratory inhibitor, to the Oomycetes pathogens such as Peronosporaceae, pythiaceae, white phytophthora section have compared with
Good inhibiting effect can influence the formation, release and sprouting of zoospore significantly.In addition, azoles is phonetic as systemic fungicide
Bacterium amine has excellent protection, treatment, holding effect and rain resistance energy, and is suitable for preventing and treating the crops such as melon, solanberry, grape
Downy mildew and epidemic disease, while can be redistributed in blade, cover crop grows up healthy and sound, and gives full play to growth potential.Permitted at present
More researchers are dedicated to researching and developing the composite bactericide containing azoles mepanipyrim: as 103798254 A of CN disclose it is a kind of phonetic containing azoles
The bactericidal composition of bacterium amine and Flutriafol；103828824 A of CN discloses one kind mepanipyrim containing azoles and thiocarbamates
Bactericidal composition；103828821 A of CN discloses one kind mepanipyrim containing azoles and methoxy acrylic bactericidal composition.
Different farm chemical ingredients are compounded, judge that agriculture chemical compounding is synergy, sums it up also by practical application effect
It is antagonism.In most cases, the effect of agriculture chemical compounding is addition, and the agriculture chemical compounding with synergistic effect is few
It is again few, the especially significant agriculture chemical compounding of synergistic effect is even more rare.So far, it is compounded about zinc thiazole and azoles mepanipyrim
Composition and application there is no people to report at present.The present inventor deeply grinds the recipe determination of zinc thiazole and azoles mepanipyrim
Study carefully, it is found that zinc thiazole and azoles mepanipyrim carry out mixture that the latter two have prevention and treatment crop disease in certain mixed ratio and expect
Less than control efficiency, synergistic effect is fairly obvious.Based on this discovery, after further study, applicant completes the present invention.
Summary of the invention
In view of the above problems, the present inventor is to solve the problems, such as that single bactericide is also easy to produce drug resistance and fungicidal spectrum is narrow,
It is found after testing repeatedly, zinc thiazole and azoles mepanipyrim compounding can be effectively prevented into disease, had significant synergies,
To cause formulation rate to reduce, so that cost also reduces.Most importantly, the mechanism of action of zinc thiazole and azoles mepanipyrim not phase
Together, the generation of pathogen resistance can be delayed.
To achieve the goals above, present invention firstly provides a kind of composition containing zinc thiazole and azoles mepanipyrim, described group
Closing object includes zinc thiazole and azoles mepanipyrim, wherein the weight ratio of the zinc thiazole and azoles mepanipyrim is 1: (0.01-50).The present invention
In the presence of effective component zinc thiazole and azoles mepanipyrim are in composition with specified weight ratio, bactericidal activity effect is greater than zinc thiazole and azoles
The bactericidal activity summation of mepanipyrim, syneryistic effect highly significant.
Preferably, in above-mentioned composition, the weight ratio of the zinc thiazole and azoles mepanipyrim is 1: (0.02-40).
It is highly preferred that the weight ratio of the zinc thiazole and azoles mepanipyrim is 1: (0.05-10) in above-mentioned composition.
Most preferably, in above-mentioned composition, the weight ratio of the zinc thiazole and azoles mepanipyrim is 1: (0.05-1).
Preferably, in above-mentioned composition, the composition also includes insecticides adjuvant, wherein the zinc thiazole and the phonetic bacterium of azoles
The sum of weight of amine is the 1%-90%, preferably 5%-80%, more preferably 15%-50% of the composition total weight,
Remaining is insecticides adjuvant.
The present composition can be prepared to agriculturally acceptable pesticidal preparations, i.e. the present composition can be made
At the various dosage forms agriculturally allowed.The pesticidal preparations (dosage form) are liquid preparation or solid pharmaceutical preparation.More preferentially, the liquid
The dosage form of body preparation is suspending agent, suspoemulsion, microcapsule suspending agent, dispersible oil-suspending agent, seed treatment suspending agent, seed treatment
Microcapsule suspending agent, suspension seed-coating agent；The dosage form of the solid pharmaceutical preparation is wettable powder, pulvis, seed treatment dry powder doses, seed
Handle dispersible pulvis, granule, dry suspending agent, water dispersible granules, effervescent tablet and/or granulae effervescentes.
The insecticides adjuvant include wetting agent, dispersing agent, emulsifier, cosurfactant, thickener, solvent, cosolvent,
Antifreezing agent, disintegrating agent, effervesce auxiliary agent, preservative, stabilizer, film forming agent, encapsulating agent, pH acid-base modifier, defoaming agent, coloring
One of agent, filler, water etc. are a variety of, the insecticides adjuvant be all in preparing commonly use or agriculturally allow using it is various at
Point, it is not particularly limited, specific ingredient and dosage are determined as desired by test.
Preferably, the wetting agent is selected from EO/PO block polyether, fatty alcohol polyoxyethylene ether, fatty alcohol ethoxylate and closes
One of object, shea butter ethyoxyl ammonium salt, alkylnaphthalene sulfonate, fatty alcohol polyoxyethylene ether sulfate, acyl group glutamate
Or it is a variety of.
Preferably, the dispersing agent is selected from condensation naphthalene sulfonate, phenolsulfonic acid condensation product sodium salt, methyl naphthalene sulfonic acid sodium formaldehyde
Condensation product, sodium lignin sulfonate, sodium metnylene bis-naphthalene sulfonate, acrylate homopolymer sodium salt, polymeric polycarboxylic acid salt, dioctyl sulphur
One of base succinic acid sodium salt, EO/PO block polyether, maleic acid-acrylic acid copolymer sodium salt are a variety of.
Preferably, the emulsifier is selected from alkyl phenol polyoxyethylene ether, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyoxy second
Alkene ether, fatty alcohol polyoxyethylene ether, phenethyl phenol polyethenoxy ether polyethenoxy ether, aliphatic amine polyoxyethylene ether, castor-oil plant oil ring
Oxidative ethane addition product and its derivative, polyol fatty acid ester and its ethylene oxide adduct, alkylbenzene sulfonate, alkyl sulfonic acid
Salt, dialkyl succinylsuccinate sulfonated ester, alkyl biphenyl base ether sulfonate, naphthalene sulfonic acid-formaldehyde condensation product, aliphatic alcohol sulfate, alkyl phenol
Polyoxyethylene ether sulfate, aralkyl phenol polyethenoxy ether sulfate, alkyl phenol polyoxyethylene ether phosphate, phenethyl phenol polyoxy
Ethylene ether phosphate, polyoxyethylene carboxylate phosphate, ethoxylated fatty amines phosphate, alkylphosphonic, alkyl phenol
Polyoxyethylene ether formaldehyde condensation products, aralkyl phenol polyethenoxy ether formaldehyde condensation products, biphenyl phenol polyethenoxy ether formaldehyde condensation products,
Polyoxyethylene polyoxypropylene block copolymer, alkyl naphthalene sulfonic acid formaldehyde condensation products, phenol formaldehyde condensate sulfonate, alkyl phenol polyoxy
It is vinethene formaldehyde condensation products sulfate, contracting methylcellulose and its derivative, alkylammonium salt, amino alcohol fatty acid derivatives, more
Amine derivative of fatty acid, quaternary ammonium salt, shea butter ethyoxyl ammonium salt, alkylnaphthalene sulfonate, amino acid, amine oxide, glycine betaine, fat
One of alcohol polyoxyethylene ether sulfate and acyl group glutamate are a variety of.
Preferably, the cosurfactant is selected from one of n-butanol, isobutanol, n-octyl alcohol, isopropanol or a variety of.
Preferably, the thickener is selected from xanthan gum, aluminum magnesium silicate, sodium carboxymethylcellulose, starch phosphate sodium, octene
One of base succinic acid starch sodium, polyvinyl alcohol are a variety of.
Preferably, the solvent is selected from one of dimethylbenzene, turpentine-based vegetable oil, methyl oleate and heavy aromatic solvent oil
Or it is a variety of.
Preferably, the cosolvent is selected from one of cyclohexanone, n,N-dimethylacetamide, n,N-Dimethylformamide
Or it is a variety of.
Preferably, the antifreezing agent in ethylene glycol, propylene glycol, glycerine, isopropanol, urea, diethylene glycol one
Kind is a variety of.
Preferably, the film forming agent selects polyvinyl alcohol, polyvinyl acetate, polyethylene glycol polymethylacrylic acid second
Diol ester, carboxymethyl cellulose, gum arabic, xanthan gum, starch etc. have the high molecular polymer of caking property and film forming.
Preferably, it is by isocyanate-monomer and polyalcohol or more that cyst material used in the encapsulating agent, which is carbamide resin,
First amine is made by interface polymerization reaction, and wherein it is different to be selected from toluene di-isocyanate(TDI), 4,4- diphenyl methane two for isocyanates
The multiple methylene polyisocyanates of cyanate, more phenyl, polyphenyl polymethylene polyisocyanates etc..
Preferably, the pH acid-base modifier be selected from citric acid, glacial acetic acid, hydrochloric acid, ammonium hydroxide, triethylamine, triethanolamine and
One of diethylenetriamine is a variety of；Institute's expense is that the pH value of final products is adjusted in stability range to be advisable.
Preferably, the disintegrating agent selects one of sodium chloride, ammonium chloride, ammonium sulfate, sodium sulphate, soluble starch or more
Kind.
Preferably, the effervesce auxiliary agent select citric acid, tartaric acid, adipic acid, fumaric acid, malic acid, potassium citrate dihydrogen,
One of tartaric acid potassium dihydrogen, succinic acid, sodium carbonate, ammonium carbonate, sodium bicarbonate, calcium carbonate, potassium carbonate, saleratus are more
Kind.
Preferably, the preservative is selected from Kathon CG, 2- benzisothiazole-3-ketone, formaldehyde, phenyl salicylate, benzoic acid
One of sodium, butyl p-hydroxybenzoate, potassium sorbate are a variety of.
Preferably, the stabilizer be selected from epoxidized soybean oil, epoxychloropropane, triphenyl phosphite, glycidol ether or
Pentaerythrite.
Preferably, the defoaming agent is selected from organic silicon defoamer and/or polyether antifoam agent.
Preferably, the colorant is selected from one of iron oxide, titanium oxide, azo dyes or a variety of.
Preferably, the filler is selected from one of kaolin, diatomite, talcum powder, precipitated calcium carbonate, white carbon black or more
Kind.
The present composition and its preparation can be prepared with universal method.Therefore, the invention also includes above-mentioned composition and
The preparation method of its preparation.
Product of the present invention can be provided in the form of finished product preparation, i.e., each substance has mixed in composition, be made
Used time is directly diluted to required concentration；The ingredient of composition can also be provided in the form of single dose, directly be existed using preceding
It is directly mixed in bucket and tank by metering, is then diluted to required concentration.
In addition, the composition is applied to prevention and treatment crop disease the present invention also provides the purposes of above-mentioned composition and preparation
Purposes.
Preferably, the crop is cucumber, capsicum, Chinese cabbage, tomato, grape, potato.
Preferably, the crop disease is cucumber bacterial angular leaf spot, pepper bacterial leaf spot, soft rot of cabbage, Huang
One of melon downy mildew, Chinese cabbage downy mildew, capsicum epidemic disease, the late blight of potato, downy mildew of garpe, tomato late blight are more
Kind.
The method that product of the present invention uses includes being applied to plant to be processed or its growth place, seed, material with mixing
With the zinc thiazole and azoles mepanipyrim reactive compound of total effective active, can germ or virus infection material, plant or seed it
It is preceding or apply later.
Terms used herein " growth place " includes growth process plant or the field for sowing cultivated plant seed, or kind
Son is embedded in the place in soil.Term " seed " includes all plant propagation materials such as nursery stock, fruit, seed, stock, connects
Fringe, cutting, sprout, root tuber, stem tuber, bulb, bulb, pollen or plant culture materials.
Composition and its preparation of the present invention can be used with itself concentration form or with dosage form, according to
Using be sprayed, spray, pourings, atomizing, dressing seed, spreading fertilizer over the fields or brushing method, application is always effective to live for the property difference of target disease
Property bactericidal amount changes with weather condition, crop condition or method of administration.
In addition, the effective component zinc thiazole in product of the present invention contains Zn-ef ficiency, not only there is bactericidal effect, it can be with
Microelement-supplementing improves crop anti-adversity and disease resistance so that plant be promoted to grow.
Compared with prior art, the present invention has the following advantages and beneficial effects:
1) synergistic effect is significant: zinc thiazole and azoles mepanipyrim show significant collaboration effect in certain ratio range
It answers, there is compared to single dose to disease the control efficiency significantly improved, reduce the usage amount and dispenser cost of pesticide；
2) use cost reduces: since zinc thiazole and azoles mepanipyrim have significant synergistic function and significantly improves
Protection effect reduces spraying times, and therefore reduces use cost, time and labour saving, has apparent economic benefit and society
Benefit；
3) generation of resistance delays: effective component zinc thiazole and azoles mepanipyrim of the invention have different mechanism of action and
Fungicidal spectrum, bactericidal effect is good, and significantly reduces the dosage of single medicament, is conducive to the production for delaying pathogen resistance
It is raw, and expand the use scope and service life of product of the present invention；
4) environmental pollution is reduced: since zinc thiazole and azoles mepanipyrim have excellent synergistic effect and protection effect, not only
Anti- pathogen, antibacterial or antibacterial effect are improved, prevention spectrum has also been enlarged, so as to reduce times for spraying, while making to apply
It is significantly reduced with dosage, therefore reduces environmental pollution and increase the safety to people and animals simultaneously.
Specific embodiment
In order to keep objects and advantages of the present invention more concise, the present invention will be explained with following specific embodiments
Bright, however, the present invention is by no means limited to these examples.Following embodiment is only the present invention more preferably embodiment, and is only used for explaining
The present invention is stated, should not be understood as limitation of the scope of the invention.It should be pointed out that all within essence and principle of the invention
Any modifications, equivalent replacements, and improvements etc. done, should all be included in the protection scope of the present invention.Therefore, the present invention is special
The scope of protection shall be subject to the appended claims for benefit.
Unless otherwise mentioned, each component used herein is commercially available or well-known in the prior art or skill
Art personnel are readily available by the disclosure of the prior art.
Example of formulations
Following term illustrates in the embodiment of the present invention that Fungicidal compounds zinc thiazole and azoles mepanipyrim are with specific mixture ratio
The composition that example is constituted.
Embodiment 1:40% zinc thiazole azoles mepanipyrim (35%+5.0%) suspending agent
By 35g zinc thiazole, 5g azoles mepanipyrim, 4g fatty alcohol polyoxyethylene ether, 2g alkylnaphthalene sulfonate, 1g methyl naphthalene sulfonic acid
Sodium formaldehyde condensation product, 0.1g gum arabic, 0.6g aluminum magnesium silicate, 2g glycerine, 0.4g sodium benzoate, the defoaming of 0.1g organosilicon
Agent, deionized water are mended to 100g, are put into high shear homogeneous emulsifying machine high speed and are sheared 20 minutes, then transport in sand mill, follow
Ring is sanded 3 times up to suspending agent.
Embodiment 2:45% zinc thiazole azoles mepanipyrim (40.0%+5.0%) suspending agent
40g zinc thiazole, 5g azoles mepanipyrim, 2g alkylnaphthalene sulfonate, 1g fatty alcohol polyoxyethylene ether sulfate, 3g is wooden
Plain sodium sulfonate, 2g starch Sodium Octenyl Succinate, 2g glycerine, 0.2g potassium sorbate, 0.1g polyether antifoam agent, distilled water mend to
100g puts into high shear homogeneous emulsifying machine high speed and shears 25 minutes, then pumps into sand mill and be sanded 90 minutes, after filtering i.e.
Obtain suspending agent.
Embodiment 3:50% zinc thiazole azoles mepanipyrim (10.0%+40.0%) suspending agent
By 10g zinc thiazole, 40g azoles mepanipyrim, 1g shea butter ethyoxyl amine salt, 2g acyl group glutamate, 2.9g dioctyl
Sulfosuccinic acid sodium salt, 3g urea, 0.1g polyether antifoam agent, deionized water are mended to 100g, and high shear homogeneous emulsifying machine is put into
High speed shear 20 minutes, then with after high pressure homogenizer homogeneous to obtain the final product 50% suspending agent.
Embodiment 4:50% zinc thiazole azoles mepanipyrim (25.0%+25.0%) suspending agent
By 25g zinc thiazole, 25g azoles mepanipyrim, 1g EO/PO block polyether, 2.1g alkylnaphthalene sulfonate, 4.3g macromolecule
Polycarboxylate, 1.5g acrylate homopolymer sodium salt, 2g n-butanol, 0.1g organic silicon defoamer, 0.5g sodium benzoate, tap water are mended
It to 100g, puts into high shear homogeneous emulsifying machine high speed and shears 30 minutes, then transport in sand mill, circulation is sanded 3 times to obtain the final product
50% suspending agent.
Embodiment 5:25% zinc thiazole azoles mepanipyrim (10.0%+15.0%) microcapsule suspending agent
10g zinc thiazole, 15g azoles mepanipyrim, 2g EO/PO block polyether, 1g alkylnaphthalene sulfonate, 0.16g organosilicon are disappeared
Infusion, 3g polyphenyl polymethylene polyisocyanates PAPI, 2g methyl diphenylene diisocyanate MDI, 10g water of gum acacia
Solution (mass fraction of Arabic gum is 5%) and 39.4g deionized water are sufficiently mixed, then are put into sand mill and be sanded, sand
Being milled to D90 partial size is 4 microns.Later on stirring (maintaining 700 turns/min), and the suspension being sanded is warming up to 60 DEG C,
It is slowly added to 0.04g triethanolamine simultaneously, maintains stable cyst material solidification temperature 8 hours, 2g poly alkyl alcohol is added later
Ethylene oxide ether sulfate, 1g alkylnaphthalene sulfonate, 2g urea, 2g glycerine, 10g sodium carboxymethyl cellulose solution (its quality
Score be 2.0%), suitable diluted hydrochloric acid aqueous solution tune pH value to 6.5 or so, 0.1g2- benzisothiazole-3-ketone and 0.3g
Organic silicon defoamer stirs evenly, and obtains 25% microcapsule suspending agent.
Embodiment 6:60% zinc thiazole azoles mepanipyrim (15.0%+45.0%) water dispersible granules
By 15g zinc thiazole, 45g azoles mepanipyrim, 4g EO/PO block polyether, 5g lignosulfonates, 15.5g sodium sulphate,
1.5g aluminum magnesium silicate, kaolin are mended to 100g and are sufficiently mixed, then by air-flow crushing, granulating and forming obtains water dispersible granules.
Embodiment 7:50% zinc thiazole azoles mepanipyrim (20.0%+30.0%) water dispersible granules
By 20g zinc thiazole, 30g azoles mepanipyrim, 7g EO/PO block polyether, 4.5g fatty alcohol polyoxyethylene ether, 10g sulfuric acid
Sodium, 1.5g starch Sodium Octenyl Succinate, diatomite are mended to 100g and are sufficiently mixed, and tap water is then added and is uniformly mixed, and throws
Enter to high shear homogeneous emulsifying machine high speed and shear corase grinding and homogeneous, then pumps and be sanded into sand mill, granulating and forming obtains later
Water dispersible granules.
Embodiment 8:60% zinc thiazole azoles mepanipyrim (40.0%+20.0%) water dispersible granules
By 40g zinc thiazole, 20g azoles mepanipyrim, 4g EO/PO block polyether, 5g fatty alcohol polyoxyethylene ether, 1g lignin
Sulfonate, 15g sodium chloride, 2g starch Sodium Octenyl Succinate, kaolin are mended to 100g and are sufficiently mixed, and it is mixed that distilled water is then added
It closes uniformly, and puts into high shear homogeneous emulsifying machine high speed shearing corase grinding and homogeneous, then pump and be sanded into sand mill, later
Granulating and forming obtains water dispersible granules.
Embodiment 9:35% zinc thiazole azoles mepanipyrim (25.0%+10.0%) wettable powder
25g zinc thiazole, 10g azoles mepanipyrim, 3g ethoxylated fatty amines phosphate, 5g sodium lignin sulfonate, 3g is white
Carbon black and 51g kaolin are sufficiently mixed, and carry out ultra-fine grinding then up to wettable powder.
Embodiment 10:60% zinc thiazole azoles mepanipyrim (50.0%+10.0%) wettable powder
By 50g zinc thiazole, 10g azoles mepanipyrim, 3g maleic acid-acrylic acid copolymer sodium salt, 5g polymeric polycarboxylic acid salt, 2g
Talcum powder, 5.5g precipitated calcium carbonate, diatomite are mended to 100g and are sufficiently mixed, and carry out ultra-fine grinding then up to wettable powder.
Embodiment 11:18% zinc thiazole azoles mepanipyrim (16.0%+2.0%) suspension seed-coating agent
16g zinc thiazole, 2g azoles mepanipyrim, 2g alkylnaphthalene sulfonate, 3g fatty alcohol polyoxyethylene ether, 2.1g acrylic acid is equal
Polymers sodium salt, 1g starch, 3.2g glycerine, 0.2g xanthan gum, 0.1g organic silicon defoamer, 0.2g azo dyes, deionized water
Benefit is sufficiently mixed to 100g, puts into high shear homogeneous emulsifying machine high speed shearing corase grinding and homogeneous later, and pump to sand mill
Middle sand milling then filters up to suspension seed-coating agent.
Embodiment 12:30% zinc thiazole azoles mepanipyrim (20.0%+10.0%) suspension seed-coating agent
By 20g zinc thiazole, 10g azoles mepanipyrim, 2g alkylnaphthalene sulfonate, 6g dioctyl sodium sulphosuccinate salt, 2g I
Uncle natural gum, 3g isopropanol, 0.2g xanthan gum, 0.6g titanium oxide, 0.1g polyether antifoam agent, distilled water are mended to 100g and are sufficiently mixed,
High shear homogeneous emulsifying machine high speed shearing corase grinding and homogeneous are put into later, and pumps and is sanded into sand mill, and then filtering is
Obtain suspension seed-coating agent.
Embodiment 13:50% zinc thiazole azoles mepanipyrim (20.0%+30.0%) suspension seed-coating agent
By 20g zinc thiazole, 30g azoles mepanipyrim, 3g polymeric polycarboxylic acid salt, 3.5g sodium metnylene bis-naphthalene sulfonate, 2g poly-vinegar
Vinyl acetate, 3g ethylene glycol, 0.2g carboxymethyl cellulose, 0.1g polyether antifoam agent, 0.4g titanium oxide, deionized water are mended to 100g
It is sufficiently mixed, puts into high shear homogeneous emulsifying machine high speed shearing corase grinding and homogeneous later, and pump and be sanded into sand mill, with
After filter up to suspension seed-coating agent.
Embodiment 14:50% zinc thiazole azoles mepanipyrim (25.0%+25.0%) seed treatment dry powder doses
25g zinc thiazole and 25g azoles mepanipyrim, 4.3g are condensed naphthalene sulfonate, 2.2g talcum powder, 15g precipitated calcium carbonate, silicon
Diatomaceous earth is mended to 100g and is sufficiently mixed, and carries out ultra-fine grinding later up to seed treatment dry powder doses.
Granula can be dispersed in embodiment 15:50% zinc thiazole azoles mepanipyrim (20.0%+30.0%) seed treatment
By 20g zinc thiazole and 30g azoles mepanipyrim, 7g EO/PO block polyether, 5g fatty alcohol polyoxyethylene ether, 7g sulfuric acid
Sodium, 1.1g aluminum magnesium silicate, kaolin is mended to 100g and is sufficiently mixed, and distilled water is added, and then puts into high shear emulsifying
Machine high speed shearing corase grinding and homogeneous, pump be sanded into sand mill later, grain can be dispersed up to seed treatment in subsequent granulating and forming
Agent.
Embodiment 16:45% zinc thiazole azoles mepanipyrim (30.0%+15.0%) seed treatment suspending agent
By 30g zinc thiazole, 15g azoles mepanipyrim, 3g shea butter ethyoxyl ammonium salt, 1g acyl group glutamate, 1g poly alkyl alcohol
Ethylene oxide ether sulfate, 2g starch Sodium Octenyl Succinate, 2g polyethylene glycol polymethylacrylic acid glycol ester, 1g season penta
Tetrol, 2g glycerine, 0.1g organic silicon defoamer, deionized water is mended to 100g and is uniformly mixed, and puts into high shear homogenized milk
Change machine high speed is sheared 25 minutes, and then pump is sanded 60 minutes into sand mill, filters suspend up to 45% seed treatment later
Agent.
Embodiment 17:35% zinc thiazole azoles mepanipyrim (30.0%+5.0%) seed treatment microcapsule suspending agent
50g zinc thiazole, 2g polymeric polycarboxylic acid salt, 0.5g polyether antifoam agent and 47.5g deionized water are sufficiently mixed, then
It is sanded, filters later up to 50.0% thiazole zincium suspension agent in investment sand mill.Then by above-mentioned 50% thiophene being prepared of 60g
Azoles zincium suspension agent, 5g azoles mepanipyrim, 2g acyl group glutamate, 2g fatty alcohol polyoxyethylene ether sulfate, 1g ocentyl succinic
Sodium starch, 2g glycerine, deionized water are mended to 100g and are mixed, and are put into high shear homogeneous emulsifying machine and be warming up to 70
DEG C, emulsifying rate is 1200 revs/min, high speed shear 25 minutes, warm bath 120 minutes, and up to 35% seed treatment micro-capsule after filtering
Suspending agent.
Embodiment 18:25% zinc thiazole azoles mepanipyrim (20.0%+5.0%) suspoemulsion
By 40g zinc thiazole, 1g EO/PO block polyether, 3g phenolsulfonic acid condensation product sodium salt, 2g propylene glycol, 0.3g xanthan
Glue, 0.1g polyether antifoam agent, deionized water are mended to 100g and are sufficiently mixed, and put into the shearing of high shear homogenized milk agent high speed
Corase grinding and homogeneous, then pump is sanded into sand mill, is filtered later up to 40.0% thiazole zincium suspension agent.Then by 50g
Above-mentioned 40% thiazole zincium suspension agent being prepared, 5g azoles mepanipyrim, 10g dimethylbenzene, 3g fatty alcohol polyoxyethylene ether sulfate,
3g ethoxylated fatty amines phosphate, 3g propylene glycol, 0.1g xanthan gum, 0.1g polyether antifoam agent and 25.8g deionized water are filled
Divide mixing, then carry out high speed shear and emulsifying, up to suspoemulsion after filtering.
Embodiment 19:30% zinc thiazole azoles mepanipyrim (20.0%+10.0%) suspoemulsion
By 40g zinc thiazole, 1g EO/PO block polyether, 2g phenolsulfonic acid condensation product sodium salt, 1g acrylate homopolymer sodium salt,
2g ethylene glycol, 0.3g xanthan gum, 0.1g polyether antifoam agent, deionized water is mended to 100g and is sufficiently mixed, and it is equal to put into high shear
Matter emulsifier high speed shearing corase grinding and homogeneous, then pump is sanded into sand mill, is filtered later up to 40.0% thiazole
Zincium suspension agent.Then by above-mentioned 40% thiazole zincium suspension agent being prepared of 50g, 10g azoles mepanipyrim, 15g dimethylbenzene, 3g naphthalene sulphur
Sour condensation product sodium salt, 5g fat alcohol ethoxyl compound, 4g ethylene glycol, 0.3g sodium carboxymethylcellulose, 0.1g polyether antifoam agent
It is sufficiently mixed with 12.6g deionized water and then carries out high speed shear and emulsifying, up to suspoemulsion after filtering.
Embodiment 20:35% zinc thiazole azoles mepanipyrim (25.0%+10.0%) suspoemulsion
By 50g zinc thiazole, 2g EO/PO block polyether, 4g acrylate homopolymer sodium salt, 2g glycerine, 0.3g xanthan gum,
0.1g potassium sorbate, 0.1g organic silicon defoamer, deionized water are mended to 100g and are sufficiently mixed, and put into high shear emulsifying
Agent high speed shearing corase grinding and homogeneous, then pump is sanded into sand mill, is filtered later up to 50% thiazole zincium suspension agent.Then
By above-mentioned 50% thiazole zincium suspension agent being prepared of 50g, 10g azoles mepanipyrim, 15g heavy aromatic solvent oil, 3g shea butter ethoxy
Base ammonium salt, 4g naphthalene sulfonic acid condensate sodium salt, 2g glycerine, 0.3g sodium carboxymethylcellulose, 0.1g organic silicon defoamer and 15.6g
Deionized water is sufficiently mixed, up to suspoemulsion after subsequent progress high speed shear and emulsifying, filtering.
Embodiment 21:50% zinc thiazole azoles mepanipyrim (35.0%+15.0%) suspoemulsion
By 70g zinc thiazole, 3g methyl naphthalene sulfonate formaldehyde condensate, 3g shea butter ethyoxyl ammonium salt, 2g glycerine, 0.3g
Xanthan gum, 0.3g Kathon CG, 0.1g polyether antifoam agent, deionized water are mended to 100g and are sufficiently mixed, and put into high shear homogenized milk
Agent high speed shearing corase grinding and homogeneous, then pump is sanded into sand mill, is filtered later up to 70.0% thiazole zincium suspension agent.
Then by above-mentioned 70% thiazole zincium suspension agent being prepared of 50g, 15g azoles mepanipyrim, 15.5g turpentine-based vegetable oil, 3g fat
Alcohol polyoxyethylene ether, 4g fat alcohol ethoxyl compound, 3g glycerine, 0.3g aluminum magnesium silicate, 0.2g polyether antifoam agent and 9g are gone
Ionized water is sufficiently mixed, and then carries out high speed shear and emulsifying, up to suspoemulsion after filtering.
The invention will be further described with reference to embodiments, and the preparation method of dosage form is conventional side in embodiment
Method, " % " of the present invention is mass percent.
Field control effectiveness test
1. test process:
Be respectively adopted 18mg/L, 90mg/L, 100mg/L, 250mg/L and 500mg/L thiazole zincium suspension agent and 5mg/L,
The azoles mepanipyrim suspending agent of 45mg/L, 90mg/L, 180mg/L, 720mg/L and 900mg/L, 7 single dose processing；And above two
The mixed combination of 7 kinds of buckets of a single dose carries out field trial to four kinds of cucumber, tomato, potato, grape crops.Test period is
2015-2016.It prevents and treats cucumber downy mildew and carries out field referring to " National Standard of the People's Republic of China GB/T17980.26-2000 "
Between pharmacodynamic test；It prevents and treats downy mildew of garpe and carries out field referring to " National Standard of the People's Republic of China GB/T17980.122-2004 "
Between pharmacodynamic test；The late blight of potato is prevented and treated to carry out referring to " National Standard of the People's Republic of China GB/T17980.34-2000 "
Field control effectiveness test；Tomato late blight is prevented and treated to carry out referring to " National Standard of the People's Republic of China GB/T17980.31-2000 "
Field control effectiveness test.
2. preventive effect is evaluated:
According to Gowing method evaluating drug effect mode, calculation formula are as follows: E0=X+Y (100-X)/100, wherein X is anti-for A single dose
It imitates (%), Y is B single dose preventive effect (%), and the practical preventive effect (%) that E A, B twos' single dose are mutually mixed works as E-E0Make when > 10% for synergy
With E-E0It is antagonism, E-E when < -10%0It is summation action when value is between -10%~10%.
The control efficiency of 1 zinc thiazole of table and azoles mepanipyrim and its mixture to cucumber downy mildew
The control efficiency of 2 zinc thiazole of table and azoles mepanipyrim and its mixture to downy mildew of garpe
The control efficiency of 3 zinc thiazole of table and azoles mepanipyrim and its mixture to the late blight of potato
The control efficiency of 4 zinc thiazole of table and azoles mepanipyrim and its mixture to tomato late blight
The above result shows that: zinc thiazole and azoles mepanipyrim are compounded in the scope of the present invention ratio, to prevention and treatment cucumber
Downy mildew, downy mildew of garpe, the late blight of potato and tomato late blight show preferable synergistic effect.
In summary, it is recommended to use the binary bactericidal composition of zinc thiazole and azoles mepanipyrim of the present invention is conducive to mutually
Increase drug effect, has no antagonism, and expand fungicidal spectrum, solve the problems, such as that plant develops drug resistance, peasant household can be substantially reduced
Use cost, simultaneously because reducing dosage and environmental pressure can be reduced.
According to the disclosure and teachings of the above specification, those skilled in the art in the invention can also be to above-described embodiment
It changes and modifies.Therefore, the invention is not limited to specific embodiments disclosed and described above, repair to some of invention
Change and change should also be as falling into the scope of the claims of the present invention.In addition, although having been used in this specification some
Specific term, these terms are merely for convenience of description, does not limit the present invention in any way.
Claims (10)
1. a kind of composition containing zinc thiazole and azoles mepanipyrim, which is characterized in that the composition includes zinc thiazole and the phonetic bacterium of azoles
Amine, wherein the weight ratio of the zinc thiazole and azoles mepanipyrim is 1: (0.01-50).
2. composition according to claim 1, which is characterized in that the weight ratio of the zinc thiazole and azoles mepanipyrim is 1:
(0.02-40)。
3. composition according to claim 1, which is characterized in that the weight ratio of the zinc thiazole and azoles mepanipyrim is 1:
(0.05-10)。
4. composition according to claim 1, which is characterized in that the weight ratio of the zinc thiazole and azoles mepanipyrim is 1:
(0.05-1)。
5. composition according to claim 1, which is characterized in that the composition also includes insecticides adjuvant, wherein described
The sum of weight of zinc thiazole and azoles mepanipyrim is the 1%-90% of the composition total weight, remaining is insecticides adjuvant.
6. composition according to claim 1-5, which is characterized in that the insecticides adjuvant includes wetting agent, divides
It is powder, emulsifier, cosurfactant, thickener, solvent, cosolvent, antifreezing agent, disintegrating agent, effervesce auxiliary agent, preservative, steady
Determine one of agent, film forming agent, encapsulating agent, pH acid-base modifier, defoaming agent, colorant, filler, water or a variety of.
7. composition according to claim 1-5, which is characterized in that the dosage form of the composition be suspending agent,
Suspoemulsion, microcapsule suspending agent, seed treatment suspending agent, seed treatment microcapsule suspending agent, suspension seed-coating agent, dispersible oil suspend
Agent, wettable powder, pulvis, seed treatment dry powder doses, seed treatment dispersible pulvis, water dispersible granules, granule, dry suspension
Agent, effervescent tablet and/or granulae effervescentes.
8. the purposes of composition according to claim 1-5, which is characterized in that the composition is applied to prevention and treatment
The purposes of crop disease.
9. purposes according to claim 8, which is characterized in that the crop be cucumber, capsicum, Chinese cabbage, tomato, grape,
Potato.
10. purposes according to claim 8, which is characterized in that the crop disease is cucumber bacterial angular leaf spot, capsicum
Bacterial leaf spot, soft rot of cabbage, cucumber downy mildew, Chinese cabbage downy mildew, capsicum epidemic disease, the late blight of potato, grape downy mildew
One of disease, tomato late blight are a variety of.
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