CN109414227A - 用于非侵入性监测物质的多路复用经皮提取和检测装置及其使用方法 - Google Patents

用于非侵入性监测物质的多路复用经皮提取和检测装置及其使用方法 Download PDF

Info

Publication number
CN109414227A
CN109414227A CN201780039263.5A CN201780039263A CN109414227A CN 109414227 A CN109414227 A CN 109414227A CN 201780039263 A CN201780039263 A CN 201780039263A CN 109414227 A CN109414227 A CN 109414227A
Authority
CN
China
Prior art keywords
pixel
electrode
glucose
sensor
gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201780039263.5A
Other languages
English (en)
Chinese (zh)
Inventor
理查德·盖伊
阿德利娜·伊利耶
卢卡·利帕尼
弗洛里安特·东梅内
伯特兰·吉尔伯特·罗格·雅克·杜邦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bath (gb) Claverton Down Bath Ba2 7ay England, University of
Original Assignee
Bath (gb) Claverton Down Bath Ba2 7ay England, University of
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1703300.2A external-priority patent/GB201703300D0/en
Application filed by Bath (gb) Claverton Down Bath Ba2 7ay England, University of filed Critical Bath (gb) Claverton Down Bath Ba2 7ay England, University of
Publication of CN109414227A publication Critical patent/CN109414227A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B2010/0009—Testing for drug or alcohol abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A61B2562/0215—Silver or silver chloride containing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • A61B2562/164—Details of sensor housings or probes; Details of structural supports for sensors the sensor is mounted in or on a conformable substrate or carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4845—Toxicology, e.g. by detection of alcohol, drug or toxic products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201780039263.5A 2016-04-26 2017-04-26 用于非侵入性监测物质的多路复用经皮提取和检测装置及其使用方法 Pending CN109414227A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1607265.4 2016-04-26
GB201607265 2016-04-26
GB1703300.2 2017-03-01
GBGB1703300.2A GB201703300D0 (en) 2017-03-01 2017-03-01 Multiplexed transdermal extraction and detection devices for non-invasive monitoring of substances and methods of use
PCT/EP2017/059909 WO2017186783A1 (en) 2016-04-26 2017-04-26 Multiplexed transdermal extraction and detection devices for non-invasive monitoring of substances and methods of use

Publications (1)

Publication Number Publication Date
CN109414227A true CN109414227A (zh) 2019-03-01

Family

ID=58632416

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780039263.5A Pending CN109414227A (zh) 2016-04-26 2017-04-26 用于非侵入性监测物质的多路复用经皮提取和检测装置及其使用方法

Country Status (5)

Country Link
US (1) US11278218B2 (https=)
EP (1) EP3448258B1 (https=)
JP (1) JP6953431B2 (https=)
CN (1) CN109414227A (https=)
WO (1) WO2017186783A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111803087A (zh) * 2020-06-12 2020-10-23 同济大学 一种生物体无损血糖检测器件及其制备方法
CN113647952A (zh) * 2021-08-18 2021-11-16 北京航空航天大学 基于银/氯化银纳米线制成的柔性干电极及其制备方法
CN114557694A (zh) * 2022-04-28 2022-05-31 中国科学院大学 一种无创皮下组织液提取-检测装置和提取-检测方法
CN116087294A (zh) * 2023-02-21 2023-05-09 青岛科技大学 一种可穿戴传感器的制备方法
CN116858914A (zh) * 2023-07-14 2023-10-10 苏州大学 一种基于疏水基底的无酶葡萄糖传感器及其制备方法和应用

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110389163A (zh) * 2018-04-16 2019-10-29 潘新宇 基于多传感器像素阵列的无创血糖检测装置
CN110501403B (zh) * 2018-05-18 2025-01-03 潘新宇 单像素无创血糖检测装置
JP7220598B2 (ja) * 2019-03-15 2023-02-10 本田技研工業株式会社 生体情報測定センサ、生体情報測定装置及び生体情報測定方法
WO2020232405A1 (en) * 2019-05-16 2020-11-19 California Institute Of Technology Laser-enabled lab on skin
WO2021231948A1 (en) * 2020-05-15 2021-11-18 Hememics Biotechnologies, Inc. Multiplex biosensor for rapid point-of-care diagnostics
KR20230123944A (ko) * 2020-11-18 2023-08-24 세르카코르 래버러토리즈, 인크. 포도당 센서 및 제조 방법
CN113017995B (zh) * 2021-03-03 2022-01-04 杭州可靠护理用品股份有限公司 具有尿酸提示功能的成人纸尿裤
US12529134B1 (en) * 2023-01-04 2026-01-20 Rhythmlink International, Llc Methods of making silver/silver chloride electrodes by vapor deposition techniques
GB2630155B (en) * 2023-10-12 2025-06-04 Transdermal Diagnostics Ltd Method and sensor
CN118058741B (zh) * 2024-02-01 2024-11-26 丽新(浙江)科技有限公司 一种用于汗液维生素b监测的柔性贴片装置

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000110A1 (en) * 1994-06-24 1996-01-04 Cygnus, Inc. Iontophoretic sampling device and method
JP2004016489A (ja) * 2002-06-17 2004-01-22 Polytronics Ltd 皮下含有物質の検査装置
US20050096520A1 (en) * 2003-11-04 2005-05-05 Sysmex Corporation Extracting device, extracting method, analyzer and analyzing method
CN101365381A (zh) * 2005-12-09 2009-02-11 弹性医疗系统有限责任公司 用于监测和递送的柔性设备和方法
CN102119860A (zh) * 2010-01-12 2011-07-13 长庚医疗器材股份有限公司 电极贴片及非侵入式血糖量测系统和测量方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2907342B2 (ja) 1988-01-29 1999-06-21 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア イオン滲透非侵襲的サンプリングまたは送出装置
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5954685A (en) 1996-05-24 1999-09-21 Cygnus, Inc. Electrochemical sensor with dual purpose electrode
US5911223A (en) 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
PT1077636E (pt) 1998-05-13 2004-06-30 Cygnus Therapeutic Systems Processamento de sinal para medicao de analitos fisiologicos
EP1270041A1 (en) 2001-06-22 2003-01-02 Universite De Geneve Device for non-invasively determining the relative levels of two substances present in a biological system
WO2007070093A2 (en) * 2005-12-09 2007-06-21 Flexible Medical Systems, Llc. Flexible apparatus and method for monitoring and delivery
US8333874B2 (en) * 2005-12-09 2012-12-18 Flexible Medical Systems, Llc Flexible apparatus and method for monitoring and delivery
JP5470509B2 (ja) 2008-11-27 2014-04-16 独立行政法人産業技術総合研究所 電極用白金クラスター及びその製造方法
US9451913B2 (en) * 2010-12-10 2016-09-27 Touchtek Labs, Llc Transdermal sampling and analysis device
US9380965B2 (en) * 2011-05-20 2016-07-05 Abbott Diabetes Care Inc. Analyte sensors having a membrane with low temperature sensitivity
JP5903806B2 (ja) 2011-09-05 2016-04-13 船井電機株式会社 検出装置
US9700245B2 (en) * 2011-09-23 2017-07-11 Itrace Biomedical Inc. Transdermal analyte extraction and detection system and the method thereof
JP6219212B2 (ja) 2014-03-27 2017-10-25 浜松ホトニクス株式会社 生体計測用プローブ及び生体計測装置
WO2016025430A1 (en) * 2014-08-11 2016-02-18 The Board Of Trustees Of The University Of Illinois Epidermal photonic systems and methods
CA2957932A1 (en) * 2014-08-11 2016-02-18 The Board Of Trustees Of The University Of Illinois Devices and related methods for epidermal characterization of biofluids
WO2016033204A2 (en) * 2014-08-26 2016-03-03 Echo Therapeutics, Inc. Differential biosensor system
US10722160B2 (en) * 2014-12-03 2020-07-28 The Regents Of The University Of California Non-invasive and wearable chemical sensors and biosensors
US10856790B2 (en) * 2015-01-09 2020-12-08 Exhalix Llc Transdermal sampling strip and method for analyzing transdermally emitted gases
US10105100B2 (en) * 2015-07-28 2018-10-23 Verily Life Sciences Llc Display on a bandage-type monitoring device
US10925543B2 (en) * 2015-11-11 2021-02-23 The Board Of Trustees Of The University Of Illinois Bioresorbable silicon electronics for transient implants
US10653342B2 (en) * 2016-06-17 2020-05-19 The Board Of Trustees Of The University Of Illinois Soft, wearable microfluidic systems capable of capture, storage, and sensing of biofluids

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996000110A1 (en) * 1994-06-24 1996-01-04 Cygnus, Inc. Iontophoretic sampling device and method
JP2004016489A (ja) * 2002-06-17 2004-01-22 Polytronics Ltd 皮下含有物質の検査装置
US20050096520A1 (en) * 2003-11-04 2005-05-05 Sysmex Corporation Extracting device, extracting method, analyzer and analyzing method
CN101365381A (zh) * 2005-12-09 2009-02-11 弹性医疗系统有限责任公司 用于监测和递送的柔性设备和方法
CN102119860A (zh) * 2010-01-12 2011-07-13 长庚医疗器材股份有限公司 电极贴片及非侵入式血糖量测系统和测量方法

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111803087A (zh) * 2020-06-12 2020-10-23 同济大学 一种生物体无损血糖检测器件及其制备方法
CN113647952A (zh) * 2021-08-18 2021-11-16 北京航空航天大学 基于银/氯化银纳米线制成的柔性干电极及其制备方法
CN114557694A (zh) * 2022-04-28 2022-05-31 中国科学院大学 一种无创皮下组织液提取-检测装置和提取-检测方法
CN116087294A (zh) * 2023-02-21 2023-05-09 青岛科技大学 一种可穿戴传感器的制备方法
CN116858914A (zh) * 2023-07-14 2023-10-10 苏州大学 一种基于疏水基底的无酶葡萄糖传感器及其制备方法和应用

Also Published As

Publication number Publication date
CA3021886A1 (en) 2017-11-02
EP3448258C0 (en) 2024-06-26
US11278218B2 (en) 2022-03-22
JP2019516452A (ja) 2019-06-20
US20200008717A1 (en) 2020-01-09
JP6953431B2 (ja) 2021-10-27
EP3448258B1 (en) 2024-06-26
WO2017186783A1 (en) 2017-11-02
EP3448258A1 (en) 2019-03-06

Similar Documents

Publication Publication Date Title
CN109414227A (zh) 用于非侵入性监测物质的多路复用经皮提取和检测装置及其使用方法
Park et al. Electrochemically active materials and wearable biosensors for the in situ analysis of body fluids for human healthcare
Das et al. Electrochemical nanosensors for sensitization of sweat metabolites: from concept mapping to personalized health monitoring
Lipani et al. Non-invasive, transdermal, path-selective and specific glucose monitoring via a graphene-based platform
Xu et al. A PEDOT: PSS conductive hydrogel incorporated with Prussian blue nanoparticles for wearable and noninvasive monitoring of glucose
Chang et al. Highly integrated watch for noninvasive continual glucose monitoring
Vora et al. Microneedle-based biosensing
Huang et al. 3D-assembled microneedle ion sensor-based wearable system for the transdermal monitoring of physiological ion fluctuations
Kim et al. Wearable bioelectronics: Enzyme-based body-worn electronic devices
US20240049994A1 (en) One-touch fingertip sweat sensor and personalized data processing for reliable prediction of blood biomarker concentrations
Manasa et al. Skin patchable sensor surveillance for continuous glucose monitoring
Sonawane et al. Stability of enzymatic biosensors for wearable applications
Samavat et al. Uniform sensing layer of immiscible enzyme-mediator compounds developed via a spray aerosol mixing technique towards low cost minimally invasive microneedle continuous glucose monitoring devices
WO2022090741A1 (en) Sensor for in vivo monitoring of an analyte
Jiao et al. Recent advances in wearable electrochemical sensors for in situ detection of biochemical markers
CN117858655A (zh) 用于可靠预测血液生物标记物浓度的单触指尖汗液传感器和个性化数据处理
JP2025505352A (ja) タッチベースの迅速な生理学的および化学的センシングのための固体センサ
Huang et al. Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species
Li et al. Boosting the performance of an iontophoretic biosensing system with a graphene aerogel and Prussian blue for highly sensitive and noninvasive glucose monitoring
Lyu et al. Soft, disruptive and wearable electrochemical biosensors
Lihong et al. Advancements and Obstacles in Sweat-Based Biosensors for Health Monitoring
Majdinasab Wearable electrochemical biosensors for glucose monitoring
Tang et al. Wearable chemosensors in physiological monitoring
Zhu et al. pH calibration allows accurate glucose detection in interstitial fluid via reverse iontophoresis
El-Desoky Voltammetric sensors for biological sample analysis

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination