JP6953431B2 - 物質の非侵襲性モニタリング用多重経皮抽出および検出装置ならびに使用方法 - Google Patents

物質の非侵襲性モニタリング用多重経皮抽出および検出装置ならびに使用方法 Download PDF

Info

Publication number
JP6953431B2
JP6953431B2 JP2018555939A JP2018555939A JP6953431B2 JP 6953431 B2 JP6953431 B2 JP 6953431B2 JP 2018555939 A JP2018555939 A JP 2018555939A JP 2018555939 A JP2018555939 A JP 2018555939A JP 6953431 B2 JP6953431 B2 JP 6953431B2
Authority
JP
Japan
Prior art keywords
array
pixel
glucose
sensor
gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018555939A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019516452A (ja
JP2019516452A5 (https=
Inventor
ガイ，リチャード
イリエ，アデリーナ
リパーニ，ルカ
ドゥオンメネ，フロリアント
デュポン，ベルトラン・ジルベール・ロジェ・ジャック
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Bath
Original Assignee
University of Bath
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1703300.2A external-priority patent/GB201703300D0/en
Application filed by University of Bath filed Critical University of Bath
Publication of JP2019516452A publication Critical patent/JP2019516452A/ja
Publication of JP2019516452A5 publication Critical patent/JP2019516452A5/ja
Application granted granted Critical
Publication of JP6953431B2 publication Critical patent/JP6953431B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B2010/0009—Testing for drug or alcohol abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Instruments for taking body samples for diagnostic purposes; Other methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A61B2010/008—Interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0209—Special features of electrodes classified in A61B5/24, A61B5/25, A61B5/283, A61B5/291, A61B5/296, A61B5/053
    • A61B2562/0215—Silver or silver chloride containing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/04—Arrangements of multiple sensors of the same type
    • A61B2562/046—Arrangements of multiple sensors of the same type in a matrix array
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A61B2562/125—Manufacturing methods specially adapted for producing sensors for in-vivo measurements characterised by the manufacture of electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
    • A61B2562/164—Details of sensor housings or probes; Details of structural supports for sensors the sensor is mounted in or on a conformable substrate or carrier
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4845—Toxicology, e.g. by detection of alcohol, drug or toxic products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2018555939A 2016-04-26 2017-04-26 物質の非侵襲性モニタリング用多重経皮抽出および検出装置ならびに使用方法 Active JP6953431B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1607265.4 2016-04-26
GB201607265 2016-04-26
GB1703300.2 2017-03-01
GBGB1703300.2A GB201703300D0 (en) 2017-03-01 2017-03-01 Multiplexed transdermal extraction and detection devices for non-invasive monitoring of substances and methods of use
PCT/EP2017/059909 WO2017186783A1 (en) 2016-04-26 2017-04-26 Multiplexed transdermal extraction and detection devices for non-invasive monitoring of substances and methods of use

Publications (3)

Publication Number Publication Date
JP2019516452A JP2019516452A (ja) 2019-06-20
JP2019516452A5 JP2019516452A5 (https=) 2020-05-21
JP6953431B2 true JP6953431B2 (ja) 2021-10-27

Family

ID=58632416

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018555939A Active JP6953431B2 (ja) 2016-04-26 2017-04-26 物質の非侵襲性モニタリング用多重経皮抽出および検出装置ならびに使用方法

Country Status (5)

Country Link
US (1) US11278218B2 (https=)
EP (1) EP3448258B1 (https=)
JP (1) JP6953431B2 (https=)
CN (1) CN109414227A (https=)
WO (1) WO2017186783A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110389163A (zh) * 2018-04-16 2019-10-29 潘新宇 基于多传感器像素阵列的无创血糖检测装置
CN110501403B (zh) * 2018-05-18 2025-01-03 潘新宇 单像素无创血糖检测装置
JP7220598B2 (ja) * 2019-03-15 2023-02-10 本田技研工業株式会社 生体情報測定センサ、生体情報測定装置及び生体情報測定方法
WO2020232405A1 (en) * 2019-05-16 2020-11-19 California Institute Of Technology Laser-enabled lab on skin
WO2021231948A1 (en) * 2020-05-15 2021-11-18 Hememics Biotechnologies, Inc. Multiplex biosensor for rapid point-of-care diagnostics
CN111803087B (zh) * 2020-06-12 2021-11-09 同济大学 一种生物体无损血糖检测器件及其制备方法
KR20230123944A (ko) * 2020-11-18 2023-08-24 세르카코르 래버러토리즈, 인크. 포도당 센서 및 제조 방법
CN113017995B (zh) * 2021-03-03 2022-01-04 杭州可靠护理用品股份有限公司 具有尿酸提示功能的成人纸尿裤
CN113647952A (zh) * 2021-08-18 2021-11-16 北京航空航天大学 基于银/氯化银纳米线制成的柔性干电极及其制备方法
CN114557694B (zh) * 2022-04-28 2022-09-23 中国科学院大学 一种无创皮下组织液提取-检测装置和提取-检测方法
US12529134B1 (en) * 2023-01-04 2026-01-20 Rhythmlink International, Llc Methods of making silver/silver chloride electrodes by vapor deposition techniques
CN116087294A (zh) * 2023-02-21 2023-05-09 青岛科技大学 一种可穿戴传感器的制备方法
CN116858914A (zh) * 2023-07-14 2023-10-10 苏州大学 一种基于疏水基底的无酶葡萄糖传感器及其制备方法和应用
GB2630155B (en) * 2023-10-12 2025-06-04 Transdermal Diagnostics Ltd Method and sensor
CN118058741B (zh) * 2024-02-01 2024-11-26 丽新(浙江)科技有限公司 一种用于汗液维生素b监测的柔性贴片装置

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2907342B2 (ja) 1988-01-29 1999-06-21 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア イオン滲透非侵襲的サンプリングまたは送出装置
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
CA2193885C (en) * 1994-06-24 2003-11-25 Janet Tamada Iontophoretic sampling device and method
US5954685A (en) 1996-05-24 1999-09-21 Cygnus, Inc. Electrochemical sensor with dual purpose electrode
US5911223A (en) 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
PT1077636E (pt) 1998-05-13 2004-06-30 Cygnus Therapeutic Systems Processamento de sinal para medicao de analitos fisiologicos
EP1270041A1 (en) 2001-06-22 2003-01-02 Universite De Geneve Device for non-invasively determining the relative levels of two substances present in a biological system
JP2004016489A (ja) * 2002-06-17 2004-01-22 Polytronics Ltd 皮下含有物質の検査装置
JP2005137416A (ja) * 2003-11-04 2005-06-02 Sysmex Corp 経皮的分析物抽出システム及び経皮的分析物分析システム
WO2007070093A2 (en) * 2005-12-09 2007-06-21 Flexible Medical Systems, Llc. Flexible apparatus and method for monitoring and delivery
US8333874B2 (en) * 2005-12-09 2012-12-18 Flexible Medical Systems, Llc Flexible apparatus and method for monitoring and delivery
CN101365381A (zh) 2005-12-09 2009-02-11 弹性医疗系统有限责任公司 用于监测和递送的柔性设备和方法
JP5470509B2 (ja) 2008-11-27 2014-04-16 独立行政法人産業技術総合研究所 電極用白金クラスター及びその製造方法
CN102119860B (zh) * 2010-01-12 2013-07-17 长庚医学科技股份有限公司 非侵入式血糖量测系统和测量方法
US9451913B2 (en) * 2010-12-10 2016-09-27 Touchtek Labs, Llc Transdermal sampling and analysis device
US9380965B2 (en) * 2011-05-20 2016-07-05 Abbott Diabetes Care Inc. Analyte sensors having a membrane with low temperature sensitivity
JP5903806B2 (ja) 2011-09-05 2016-04-13 船井電機株式会社 検出装置
US9700245B2 (en) * 2011-09-23 2017-07-11 Itrace Biomedical Inc. Transdermal analyte extraction and detection system and the method thereof
JP6219212B2 (ja) 2014-03-27 2017-10-25 浜松ホトニクス株式会社 生体計測用プローブ及び生体計測装置
WO2016025430A1 (en) * 2014-08-11 2016-02-18 The Board Of Trustees Of The University Of Illinois Epidermal photonic systems and methods
CA2957932A1 (en) * 2014-08-11 2016-02-18 The Board Of Trustees Of The University Of Illinois Devices and related methods for epidermal characterization of biofluids
WO2016033204A2 (en) * 2014-08-26 2016-03-03 Echo Therapeutics, Inc. Differential biosensor system
US10722160B2 (en) * 2014-12-03 2020-07-28 The Regents Of The University Of California Non-invasive and wearable chemical sensors and biosensors
US10856790B2 (en) * 2015-01-09 2020-12-08 Exhalix Llc Transdermal sampling strip and method for analyzing transdermally emitted gases
US10105100B2 (en) * 2015-07-28 2018-10-23 Verily Life Sciences Llc Display on a bandage-type monitoring device
US10925543B2 (en) * 2015-11-11 2021-02-23 The Board Of Trustees Of The University Of Illinois Bioresorbable silicon electronics for transient implants
US10653342B2 (en) * 2016-06-17 2020-05-19 The Board Of Trustees Of The University Of Illinois Soft, wearable microfluidic systems capable of capture, storage, and sensing of biofluids

Also Published As

Publication number Publication date
CN109414227A (zh) 2019-03-01
CA3021886A1 (en) 2017-11-02
EP3448258C0 (en) 2024-06-26
US11278218B2 (en) 2022-03-22
JP2019516452A (ja) 2019-06-20
US20200008717A1 (en) 2020-01-09
EP3448258B1 (en) 2024-06-26
WO2017186783A1 (en) 2017-11-02
EP3448258A1 (en) 2019-03-06

Similar Documents

Publication Publication Date Title
JP6953431B2 (ja) 物質の非侵襲性モニタリング用多重経皮抽出および検出装置ならびに使用方法
EP4153276B1 (en) Fault detection for microneedle array based continuous analyte monitoring device
Teymourian et al. Electrochemical glucose sensors in diabetes management: an updated review (2010–2020)
Chinnadayyala et al. Nonenzymatic determination of glucose at near neutral pH values based on the use of nafion and platinum black coated microneedle electrode array
Tasca et al. Microneedle-based electrochemical devices for transdermal biosensing: a review
De la Paz et al. Non-invasive monitoring of interstitial fluid lactate through an epidermal iontophoretic device
DE69910003T2 (de) Überwachung physiologischer analyte
JP3366646B2 (ja) 化学シグナル非透過性マスク
US20020019604A1 (en) Electrochemical sensor with dual purpose electrode
US20160331290A1 (en) Biosensor electrode structure and biosensor including the same
CN106725470B (zh) 一种连续或非连续的生理参数分析系统
CN114748064A (zh) 空心微针垂直石墨烯传感器及制备方法
JP2006167428A (ja) 分析物抽出装置、分析装置、分析物抽出方法および分析方法
Zhan et al. A 3D-printed microneedle extraction system integrated with patterned electrodes for minimally invasive transdermal detection
Li et al. Boosting the performance of an iontophoretic biosensing system with a graphene aerogel and Prussian blue for highly sensitive and noninvasive glucose monitoring
Wang et al. Monitoring & healing dual channel system designed for continuous glucose monitoring decorated with high-efficient self-healing CuO nanoflakes glucose catalytic electrode
CA3021886C (en) Multiplexed transdermal extraction and detection devices for non-invasive monitoring of substances and methods of use
CN117379048A (zh) 微针电极阵列及制备方法、微针阵列贴片式传感装置
WO2024010976A1 (en) Flexible biosensor for the detection and/or 2d/3d mapping of biomarker concentration
El-Desoky Voltammetric sensors for biological sample analysis
Yoon et al. A Flexible Electrochemical-Physiological Epidermal Hybrid Patch for Chronic Disease Management
Tehrani Lab-under-the-skin: a microneedle platform for electrochemical wearable sensing
CN119915881B (zh) 一种葡萄糖生物传感器及其制备方法和应用
TWI571238B (zh) 非侵入式代謝產物偵測裝置
Mohan et al. Wearable biosensor platform: design and healthcare commercial values

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200408

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20200408

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20210226

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210303

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210602

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210802

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210908

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210929

R150 Certificate of patent or registration of utility model

Ref document number: 6953431

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250