CN109395020A - 一种治疗甲亢的药物组合物及其制备方法 - Google Patents
一种治疗甲亢的药物组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗甲亢的药物组合物及其制备方法,本发明的组合物以丹参、川芎、赤芍、青皮、青木香理气活血;以牛黄、熊胆、番红花、三七调节生理功能;以羚羊角、瓦楞子、甲珠、海藻、昆布、三棱、莪术、皂角刺攻坚散结;以胆南星、白芥子、浙贝母、金银花、连翘、夏枯草、半枝莲、生大黄化毒排浊;以甘草解毒,调和诸药,共奏治疗甲亢病的奇功。本发明通过各原料的协同作用,药效相辅相成,相得益彰,通过疏肝理气,对甲亢及并发症进行根本性治疗,还可以增加患者机体的免疫功能。
Description
技术领域
本发明属于医药技术领域,具体涉及一种治疗甲亢的药物组合物及其制备方法。
背景技术
甲状腺功能亢进症简称“甲亢”,是由于甲状腺合成释放过多的甲状腺激素,造成机体代谢亢进和交感神经兴奋,引起心悸、出汗、进食和便次增多和体重减少的病症。多数患者还常常同时有突眼、眼睑水肿、视力减退等症状。绝大多数患者甲亢(80%以上)是由弥漫性毒性甲状腺肿(Graves病)引起的。Graves病为自身免疫疾病,患者淋巴细胞产生了刺激甲状腺的特异性抗体。近年来,人们生活节奏日益加快,精神压力大,睡眠不足,Graves病发病率逐年升高,严重影响了人们的身体健康。
目前,西医在治疗上常用的抗甲亢病的药物分为硫脲类和咪唑类,前者为甲基硫氧嘧啶、丙基硫氧嘧啶,后者为他巴唑和甲亢平,两类药物主要以抵制过氧化酶对于无机碘的活化而阻止甲状腺激素的合成,达到治疗的目的,停药后容易复发,治标不治本,且长期服用对人体健康有影响,不适合长期服用。
鉴于以上原因,特提出本发明。
发明内容
为了解决现有技术存在的以上问题,本发明提供了一种治疗甲亢的药物组合物及其制备方法,本发明的药物组合物治疗甲亢效果好,不易复发,没有副作用,见效快,治愈率高。
为了实现上述目的,本发明采用如下技术方案:
一种治疗甲亢的药物组合物,按照重量份,包括如下原料:丹参24-36重量份、川芎12-18重量份、赤芍24-36重量份、牛黄5-7重量份、熊胆2-4重量份、番红花7.5-10.5重量份、三七5-7重量份、青皮8-12重量份、青木香12-18重量份、胆南星8-12重量份、白芥子8-12重量份、羚羊角8-10重量份、瓦楞子24-36重量份、甲珠8-12重量份、海藻12-18重量份、昆布12-18重量份、三棱12-18重量份、莪术12-18重量份、皂角刺24-36重量份、浙贝母8-12重量份、金银花12-18重量份、连翘12-18重量份、夏枯草24-36重量份、半枝莲24-36重量份、生大黄12-18重量份和甘草5-7重量份。
丹参具有活血祛瘀,安神宁心,排脓,止痛。治心绞痛,月经不调,痛经,经闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒的功效。
川芎常用于活血行气,祛风止痛,川芎辛温香燥,走而不守,既能行散,上行可达巅顶;又入血分,下行可达血海。活血祛瘀作用广泛,适宜瘀血阻滞各种病症;祛风止痛,效用甚佳,可治头风头痛、风湿痹痛等症。
赤芍止痛、祛瘀、消肿、活血散瘀、清热凉血。
牛黄息风止痉,清心肝热,化痰开窍,清热解毒。
熊胆有清热解毒、平肝明目、杀虫止血的功效。
番红花活血化瘀,凉血解毒,解郁安神。用于经闭症瘕、产后瘀阻、温毒发斑、忧郁痞闷、惊悸发狂。
三七止血,散瘀,消肿,定痛。治吐血,咳血,衄血,便血,血痢,崩漏,癥瘕,产后血晕,恶露不下,跌扑瘀血,外伤出血,痈肿疼痛。
青皮主要含挥发油类、黄酮类橙皮苷以及对羟福林。具有疏肝破气,消积化滞的功效。用于胸胁胀痛、疝气、乳核、乳痈、食积腹痛等症状。
青木香行气,解毒,消肿。治胸腹胀痛,痧症,肠炎下痢,高血压,疝气,蛇咬毒,痈肿,疔疮,皮肤瘙痒或湿烂。
胆南星有清热化痰,胆南星苦凉,苦能燥湿化痰,寒能清热功效,可用治痰火咳嗽,头风眩晕,中风痰壅,老年神困,产后怔忡,痰火失眠等症状。
白芥子温肺豁痰利气,乳腺散结通络止痛。用于寒痰喘咳,胸胁胀痛,痰滞经络,关节麻木、疼痛,痰湿流注,阴疽肿毒。
羚羊角平肝息风,清肝明目,散血解毒,用于肝风内动,惊痫抽搐,妊娠子痫,高热痉厥,癫痫发狂,头痛眩晕,目赤翳障,温毒发斑,痈肿疮毒。
瓦楞子作用是消痰化瘀,软坚散结,制酸止痛,治瘰疬,顽痰久咳,胃痛吐酸。
甲珠性微寒,归肝经、胃经。能活血散结、通经下乳、消痈溃坚。主血瘀经闭、症瘕、风湿痹痛、乳汁不下、痈肿、瘰疬等。
海藻性味咸寒,具有清热、软坚散结的功效。
昆布气腥,味咸。归肝、胃、肾经。有软坚散结,消痰,利水之功能。用于痰饮水肿。软坚散结,瘿瘤、瘰疬、睾丸肿痛、痰饮水肿。
三棱用于症瘕痞块,痛经,瘀血经闭,胸痹心痛,食积胀痛。
莪术主治“气血凝滞,心腹胀痛,症瘕,积聚,宿食不消,妇女血瘀经闭,跌打损伤作痛。”块根称“绿丝郁金”,有行气解郁,破瘀,止痛的功用。
皂角刺辛散温通,性极锐利,能攻走血脉,直达病所,攻散之力较强,故有消肿托毒排脓之功,凡痈疽肿毒,未成能消,已成能溃,为外科常用药。
浙贝母用于清热化痰、散结消肿、止咳,还能主治风热犯肺、痰火咳嗽、肺痈、乳痈、瘰疬、疮毒等。
金银花性甘寒气芳香,甘寒清热而不伤胃,芳香透达又可祛邪。金银花既能宣散风热,还善清解血毒,用于各种热性病,如身热、发疹、发斑、热毒疮痈、咽喉肿痛等症,均效果显著。
连翘清热解毒、消肿散结、消炎。
夏枯草治疗目赤肿痛、头痛的作用。还能清肝火、降血压、散结消肿等。
半枝莲清热解毒、活血化瘀、利尿。属清热药下属中的清热解毒药。
生大黄具有很强的抗感染作用、抗衰老抗氧化作用、能够调节免疫、抗炎、解热作用、抗病原微生物作用、降血脂、止血作用、抗胃及十二指肠溃疡、促进胰液分泌、抑制胰酶活性、利胆、保肝、泻下作用。
甘草气微,味甜而特殊。功能主治清热解毒、祛痰止咳、脘腹等。本发明的组合物以丹参、川芎、赤芍、青皮、青木香理气活血;以牛黄、熊胆、番红花、三七调节生理功能;以羚羊角、瓦楞子、甲珠、海藻、昆布、三棱、莪术、皂角刺攻坚散结;以胆南星、白芥子、浙贝母、金银花、连翘、夏枯草、半枝莲、生大黄化毒排浊;以甘草解毒,调和诸药,共奏治疗甲亢病的奇功。本发明通过各原料的协同作用,药效相辅相成,相得益彰,通过疏肝理气,对甲亢及并发症进行根本性治疗,还可以增加患者机体的免疫功能。
进一步的,按照重量份,包括如下原料:丹参28-32重量份、川芎14-16重量份、赤芍28-32重量份、牛黄5.5-6.5重量份、熊胆2.5-3.5重量份、番红花8.5-9.5重量份、三七5.5-6.5重量份、青皮9-11重量份、青木香14-16重量份、胆南星9-11重量份、白芥子9-11重量份、羚羊角8.5-9.5重量份、瓦楞子28-32重量份、甲珠9-11重量份、海藻14-16重量份、昆布14-16重量份、三棱14-16重量份、莪术14-16重量份、皂角刺28-32重量份、浙贝母9-11重量份、金银花14-16重量份、连翘14-16重量份、夏枯草28-32重量份、半枝莲28-32重量份、生大黄14-16重量份和甘草5.5-6.5重量份。
进一步的,按照重量份,包括如下原料:丹参30重量份、川芎15重量份、赤芍30重量份、牛黄6重量份、熊胆3重量份、番红花9重量份、三七6重量份、青皮10重量份、青木香15重量份、胆南星10重量份、白芥子10重量份、羚羊角9重量份、瓦楞子30重量份、甲珠10重量份、海藻15重量份、昆布15重量份、三棱15重量份、莪术15重量份、皂角刺30重量份、浙贝母10重量份、金银花15重量份、连翘15重量份、夏枯草30重量份、半枝莲30重量份、生大黄15重量份和甘草6重量份。
进一步的,所述的组合物为可制备成药学上可接受的剂型,优选为丸剂或膏剂。
本发明还提供了一种所述的治疗甲亢的药物组合物的制备方法,所述的组合物为丸剂,制备方法如下:
(1)取每味中药原料,分别进行消毒灭菌处理;
(2)然后进行粉碎,加入蜂蜜,制成细丸,得到所述的丸剂。
进一步的,步骤(1)中消毒灭菌处理采用大于52°的白酒进行炙制。
在白酒中炙制不仅可以起到消毒灭菌的作用,而且还可以增强药力,将各药物的活性成分提高,采用本发明的炙制方法,得到的组合物治疗效果更好。
进一步的,步骤(2)中所有中药原料的总质量与蜂蜜的质量比为1:4-5,所述细丸的质量为0.15-0.25g/丸,优选的细丸的质量为0.2g/丸。
本发明的丸剂的服用方法:成人每天3次,每次9-12g,餐后90-120分钟服药,温开水送服,服药后60-90分钟不可进食。儿童用量减半。
注意事项:1、服药不能间断。2、禁食白糖、葱、姜、蒜等辛辣食物及地瓜、土豆、柿子、茄子、板栗等滞气食品。
进一步的,所述的组合物为膏剂,制备方法如下:取中药原料清除杂质,放入温水中浸泡1.5-2.5h,然后大火煮沸,再以小火慢炖,榨汁,浓缩,得到所述的膏剂。
进一步的,温水的质量与中药原料总质量之比为2.5-3.5:1,优选的,质量比为3:1,温水的温度为25-35℃。
进一步的,大火煮沸3-7min,小火慢炖80-100min,优选的,大火煮沸5min,小火慢炖90min。
本发明的膏剂的服用方法:成人每天3次,每次120-150ml,餐后90-120分钟服药,温开水送服,服药后60-90分钟不可进食。儿童用量减半。
注意事项:1、服药不能间断。2、禁食白糖、葱、姜、蒜等辛辣食物及地瓜、土豆、柿子、茄子、板栗等滞气食品。
与现有技术相比,本发明的有益效果为:
(1)本发明的治疗甲亢的药物组合物通过各原料的协同作用,药效相辅相成,相得益彰,通过疏肝理气,对甲亢及并发症进行根本性治疗,还可以增加患者机体的免疫功能,降低患者的急速水平,且药效平和,服用方便,无毒副作用,见效快,治愈率高,不易复发;
(2)本发明的制备方法简单,可以将各原料的有效成分充分的提取出来,不添加任何辅料,保持了天然药物的有效成分。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚,下面将对本发明的技术方案进行详细的描述。显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动的前提下所得到的所有其它实施方式,都属于本发明所保护的范围。
实施例1
一种治疗甲亢的药物组合物,包括如下原料:丹参24g、川芎12g、赤芍24g、牛黄5g、熊胆2g、番红花7.5g、三七5g、青皮8g、青木香12g、胆南星8g、白芥子8g、羚羊角8g、瓦楞子24g、甲珠8g、海藻12g、昆布12g、三棱12g、莪术12g、皂角刺24g、浙贝母8g、金银花12g、连翘12g、夏枯草24g、半枝莲24g、生大黄12g和甘草5g。
本实施例的中药组合物为丸剂,制备方法如下:
(1)取每味中药原料,清除杂质与异物,分别在53°的白酒中进行炙制,起到了消毒灭菌的作用,同时还可以增强药力的效果;
(2)然后采用纳米粉碎技术将各原料进行粉碎,加入油菜花蜂蜜,中药原料的总质量与蜂蜜的质量比为1:4,制成细丸,所述细丸的质量为0.15g/丸,得到所述的丸剂。
实施例2
一种治疗甲亢的药物组合物,包括如下原料:丹参28g、川芎14g、赤芍28g、牛黄5.5g、熊胆2.5g、番红花8.5g、三七5.5g、青皮9g、青木香14g、胆南星9g、白芥子9g、羚羊角8.5g、瓦楞子28g、甲珠9g、海藻14g、昆布142g、三棱14g、莪术14g、皂角刺28g、浙贝母9g、金银花14g、连翘14g、夏枯草28g、半枝莲28g、生大黄14g和甘草5.5g。
本实施例的药物组合物为丸剂,制备方法如下:
(1)取每味中药原料,清除杂质与异物,分别在55°的白酒中进行炙制,起到了消毒灭菌的作用,同时还可以增强药力的效果;
(2)然后采用纳米粉碎技术将各原料进行粉碎,加入油菜花蜂蜜,中药原料的总质量与蜂蜜的质量比为1:4.5,制成细丸,所述细丸的质量为0.2g/丸,得到所述的丸剂。
实施例3
一种治疗甲亢的药物组合物,包括如下原料:丹参30g、川芎15g、赤芍30g、牛黄6g、熊胆3g、番红花9g、三七6g、青皮10g、青木香15g、胆南星10g、白芥子10g、羚羊角9g、瓦楞子30g、甲珠10g、海藻15g、昆布15g、三棱15g、莪术15g、皂角刺30g、浙贝母10g、金银花15g、连翘15g、夏枯草30g、半枝莲30g、生大黄15g和甘草6g。
本实施例的药物组合物为丸剂,制备方法如下:
(1)取每味中药原料,清除杂质与异物,分别在58°的白酒中进行炙制,起到了消毒灭菌的作用,同时还可以增强药力的效果;
(2)然后采用纳米粉碎技术将各原料进行粉碎,加入油菜花蜂蜜,中药原料的总质量与蜂蜜的质量比为1:5,制成细丸,所述细丸的质量为0.25g/丸,得到所述的丸剂。
实施例1-3的丸剂的服用方法:成人每天3次,每次9-12g,餐后90-120分钟服药,温开水送服,服药后60-90分钟不可进食。儿童用量减半。
注意事项:1、服药不能间断。2、禁食白糖、葱、姜、蒜等辛辣食物及地瓜、土豆、柿子、茄子、板栗等滞气食品。
实施例4
一种治疗甲亢的药物组合物,包括如下原料:丹参32g、川芎16g、赤芍32g、牛黄6.5g、熊胆3.5g、番红花9.5g、三七6.5g、青皮11g、青木香16g、胆南星11g、白芥子11g、羚羊角9.5g、瓦楞子32g、甲珠11g、海藻16g、昆布16g、三棱16g、莪术16g、皂角刺32g、浙贝母11g、金银花16g、连翘16g、夏枯草32g、半枝莲32g、生大黄16g和甘草6.5g。
本实施例的药物组合物为膏剂,制备方法如下:取中药原料清除杂质,放入25℃的温水中浸泡1.5h,温水的质量与中药原料总质量之比为2.5:1,连药带水放入瓦锅,然后大火煮沸3min,再以小火慢炖80min,榨取药汁,浓缩,得到所述的膏剂。
实施例5
一种治疗甲亢的药物组合物,包括如下原料:丹参36g、川芎18g、赤芍36g、牛黄7g、熊胆4g、番红花10.5g、三七7g、青皮12g、青木香18g、胆南星12g、白芥子12g、羚羊角10g、瓦楞子36g、甲珠12g、海藻18g、昆布18g、三棱18g、莪术18g、皂角刺36g、浙贝母12g、金银花18g、连翘18g、夏枯草36g、半枝莲36g、生大黄18g和甘草7g。
本实施例的药物组合物为膏剂,制备方法如下:取中药原料清除杂质,放入35℃的温水中浸泡2.5h,温水的质量与中药原料总质量之比为3.5:1,连药带水放入瓦锅,然后大火煮沸7min,再以小火慢炖100min,榨取药汁,浓缩,得到所述的膏剂。
实施例6
一种治疗甲亢的药物组合物,包括如下原料:丹参30g、川芎15g、赤芍30g、牛黄6g、熊胆3g、番红花9g、三七6g、青皮10g、青木香15g、胆南星10g、白芥子10g、羚羊角9g、瓦楞子30g、甲珠10g、海藻15g、昆布15g、三棱15g、莪术15g、皂角刺30g、浙贝母10g、金银花15g、连翘15g、夏枯草30g、半枝莲30g、生大黄15g和甘草6g。
本实施例的药物组合物为膏剂,制备方法如下:取中药原料清除杂质,放入30℃的温水中浸泡2h,温水的质量与中药原料总质量之比为3:1,连药带水放入瓦锅,然后大火煮沸5min,再以小火慢炖90min,榨取药汁,浓缩,得到所述的膏剂。
实施例4-6的膏剂的服用方法:成人每天3次,每次120-150ml,餐后90-120分钟服药,温开水送服,服药后60-90分钟不可进食。儿童用量减半。
注意事项:1、服药不能间断。2、禁食白糖、葱、姜、蒜等辛辣食物及地瓜、土豆、柿子、茄子、板栗等滞气食品。
试验例1
选取甲亢患者356人,服用实施例3制备的丸剂,每天服用3次,每次12g,餐后90-120分钟服用,温开水送服,服药后60-90分钟不可进食,连续服用1个月,有效标准、显效率和治愈率均以国家医疗检查统一标准为准。效果见表1。
表1
治疗效果 | 有效 | 显效率 | 临床治愈 |
人数 | 277 | 242 | 210 |
百分率 | 78% | 68% | 59% |
本发明人也对其他实施例制备的中药组合物进行了上述的试验,结果基本一致,由于篇幅有限,不再一一列举。
以上所述,仅为本发明的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,可轻易想到变化或替换,都应涵盖在本发明的保护范围之内。因此,本发明的保护范围应以所述权利要求的保护范围为准。
Claims (10)
1.一种治疗甲亢的药物组合物,其特征在于,按照重量份,包括如下原料:丹参24-36重量份、川芎12-18重量份、赤芍24-36重量份、牛黄5-7重量份、熊胆2-4重量份、番红花7.5-10.5重量份、三七5-7重量份、青皮8-12重量份、青木香12-18重量份、胆南星8-12重量份、白芥子8-12重量份、羚羊角8-10重量份、瓦楞子24-36重量份、甲珠8-12重量份、海藻12-18重量份、昆布12-18重量份、三棱12-18重量份、莪术12-18重量份、皂角刺24-36重量份、浙贝母8-12重量份、金银花12-18重量份、连翘12-18重量份、夏枯草24-36重量份、半枝莲24-36重量份、生大黄12-18重量份和甘草5-7重量份。
2.根据权利要求1所述的治疗甲亢的药物组合物,其特征在于,按照重量份,包括如下原料:丹参28-32重量份、川芎14-16重量份、赤芍28-32重量份、牛黄5.5-6.5重量份、熊胆2.5-3.5重量份、番红花8.5-9.5重量份、三七5.5-6.5重量份、青皮9-11重量份、青木香14-16重量份、胆南星9-11重量份、白芥子9-11重量份、羚羊角8.5-9.5重量份、瓦楞子28-32重量份、甲珠9-11重量份、海藻14-16重量份、昆布14-16重量份、三棱14-16重量份、莪术14-16重量份、皂角刺28-32重量份、浙贝母9-11重量份、金银花14-16重量份、连翘14-16重量份、夏枯草28-32重量份、半枝莲28-32重量份、生大黄14-16重量份和甘草5.5-6.5重量份。
3.根据权利要求2所述的治疗甲亢的药物组合物,其特征在于,按照重量份,包括如下原料:丹参30重量份、川芎15重量份、赤芍30重量份、牛黄6重量份、熊胆3重量份、番红花9重量份、三七6重量份、青皮10重量份、青木香15重量份、胆南星10重量份、白芥子10重量份、羚羊角9重量份、瓦楞子30重量份、甲珠10重量份、海藻15重量份、昆布15重量份、三棱15重量份、莪术15重量份、皂角刺30重量份、浙贝母10重量份、金银花15重量份、连翘15重量份、夏枯草30重量份、半枝莲30重量份、生大黄15重量份和甘草6重量份。
4.根据权利要求1-3任意一项所述的治疗甲亢的药物组合物,其特征在于,所述的组合物为可制备成药学上可接受的剂型,优选为丸剂或膏剂。
5.一种权利要求4所述的治疗甲亢的药物组合物的制备方法,其特征在于,所述的组合物为丸剂,制备方法如下:
(1)取每味中药原料,分别进行消毒灭菌处理;
(2)然后进行粉碎,加入蜂蜜,制成细丸,得到所述的丸剂。
6.根据权利要求5所述的治疗甲亢的药物组合物的制备方法,其特征在于,步骤(1)中消毒灭菌处理采用大于52°的白酒进行炙制。
7.根据权利要求5所述的治疗甲亢的药物组合物的制备方法,其特征在于,步骤(2)中所有中药原料的总质量与蜂蜜的质量比为1:4-5,所述细丸的质量为0.15-0.25g/丸,优选的,细丸的质量为0.2g/丸。
8.一种权利要求4所述的治疗甲亢的药物组合物的制备方法,其特征在于,所述的组合物为膏剂,制备方法如下:取中药原料清除杂质,放入温水中浸泡1.5-2.5h,然后大火煮沸,再以小火慢炖,榨汁,浓缩,得到所述的膏剂。
9.根据权利要求8所述的治疗甲亢的药物组合物的制备方法,其特征在于,温水的质量与中药原料总质量之比为2.5-3.5:1,优选的,质量比为3:1,温水的温度为25-35℃。
10.根据权利要求8所述的治疗甲亢的药物组合物的制备方法,其特征在于,大火煮沸3-7min,小火慢炖80-100min,优选的,大火煮沸5min,小火慢炖90min。
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104189742A (zh) * | 2014-08-15 | 2014-12-10 | 济南环太机电技术有限公司 | 一种治疗甲状腺亢进的中药膏剂 |
CN104474471A (zh) * | 2014-12-01 | 2015-04-01 | 张京玲 | 一种治疗甲状腺的中药组合物 |
CN109432354A (zh) * | 2018-11-27 | 2019-03-08 | 李天基 | 一种治疗甲状腺癌的药物及其制备方法 |
-
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104189742A (zh) * | 2014-08-15 | 2014-12-10 | 济南环太机电技术有限公司 | 一种治疗甲状腺亢进的中药膏剂 |
CN104474471A (zh) * | 2014-12-01 | 2015-04-01 | 张京玲 | 一种治疗甲状腺的中药组合物 |
CN109432354A (zh) * | 2018-11-27 | 2019-03-08 | 李天基 | 一种治疗甲状腺癌的药物及其制备方法 |
Non-Patent Citations (1)
Title |
---|
张永杰等: "王立琴治疗甲状腺机能亢进症经验", 《中医杂志》 * |
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