CN109394955A - A kind of Chinese medicine composition and preparation method thereof for treating osteoarthritis and osteonecrosis - Google Patents
A kind of Chinese medicine composition and preparation method thereof for treating osteoarthritis and osteonecrosis Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/487—Psoralea
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The present invention relates to field of Chinese medicinal composition, provide a kind of Chinese medicine composition and preparation method thereof for treating osteoarthritis and osteonecrosis.The component of the drug includes 20-40 parts of teasel root, 8-18 parts of Radix Salviae Miltiorrhizae, 8-18 parts of psoralea corylifolia, 8-18 parts of radix achyranthis bidentatae, 8-18 parts of corydalis tuber, 20-140 parts of Herba Epimedii, 8-18 parts of rhizoma anemarrhenae, 8-18 parts of Rehmannia glutinosa and 8-18 parts of Cortex Eucommiae according to parts by weight.Preparation method includes that the component of the Chinese medicine composition of above-mentioned treatment osteoarthritis and osteonecrosis is mixed to tanning or granulation.It cooperates between each component of the present embodiment, can be effectively relieved and treat the symptoms such as osteoarthritis and osteonecrosis.
Description
Technical field
The present invention relates to field of Chinese medicinal composition, in particular to a kind of Chinese medicine for treating osteoarthritis and osteonecrosis
Composition and preparation method thereof.
Background technique
Osteoarthritis is a kind of retrogression pathological changes, is due to increasing age, obesity, strain, wound, joint birth defect, closing
The damage of articular cartilage degeneration caused by the factors such as deformity, joint margins and subchondral bone reactive hyperplasia are saved, also known as bone closes
Save disease, degenerative arthritis, senescent arthritis, hypertrophiarthritis etc..Clinical manifestation is the arthralgia slowly developed, pressure
Bitterly, stiff, arthroncus, limitation of activity and joint deformity etc..
Summary of the invention
The purpose of the present invention can for example including a kind of Chinese medicine composition for treating osteoarthritis and osteonecrosis is provided
Effectively treatment osteoarthritis and osteonecrosis, alleviate its pain symptom.
The purpose of the present invention further includes providing a kind of preparation method of Chinese medicine composition for treating osteoarthritis and osteonecrosis,
The preparation method is simple, easy to accomplish.
The embodiment of the present invention is achieved in that
A kind of Chinese medicine composition for treating osteoarthritis and osteonecrosis, component include teasel root 20-40 according to parts by weight
It is part, 8-18 parts of Radix Salviae Miltiorrhizae, 8-18 parts of psoralea corylifolia, 8-18 parts of radix achyranthis bidentatae, 8-18 parts of corydalis tuber, 20-140 parts of Herba Epimedii, 8-18 parts of rhizoma anemarrhenae, ripe
8-18 parts of glutinous rehmannia and 8-18 parts of Cortex Eucommiae.
A kind of preparation method of Chinese medicine composition that treating osteoarthritis and osteonecrosis comprising by above-mentioned treatment Bones and joints
The component mixing tanning or granulation of scorching and osteonecrosis Chinese medicine composition.
The beneficial effect of the embodiment of the present invention is: the Chinese traditional medicine composition for the treatment of osteoarthritis and osteonecrosis provided in this embodiment
Object using teasel root and Herba Epimedii as monarch drug in a prescription, teasel root can nourishing liver and kidney, enhance muscles and bones, injury of tendon and muscle fracture, injury from falling down etc. be effectively relieved
Illness, and Herba Epimedii can tonifying kidney and strengthening yang, alleviate by pain in low back and legs caused by osteoarthritis or osteonecrosis, numb limb, half
The unsuccessful equal diseases of body.Rehmannia glutinosa and Cortex Eucommiae can further nourishing liver and kidney, take into account nourishing liver and kidney with psoralea corylifolia and rhizoma anemarrhenae, strong taste connect
With Radix Salviae Miltiorrhizae, radix achyranthis bidentatae and corydalis tuber carry out activating microcirculation and removing stasis medicinal, prevent the region stasis blocking of osteoarthritis and osteonecrosis obstructed, QI-blood circulation is just
Often.Cooperate between each component of the present embodiment, combined from internal cause and external cause be effectively relieved and treat osteoarthritis and
The symptoms such as osteonecrosis.Further it is provided that preparation method it is simple, can directly mixing and water adding be brewed into decoction, can also part
Pulverizing medicinal materials, the tanning of part medicinal material, last mixing granulation, our experiments show that, by teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber point
It does not crush, and is added in thick paste according to a graded, the effect of the Chinese medicine composition of the treatment osteoarthritis and osteonecrosis of acquisition
More preferably.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the invention.It is not specified in embodiment specific
Condition person carries out according to conventional conditions or manufacturer's recommended conditions.Reagents or instruments used without specified manufacturer is
The conventional products that can be obtained by commercially available purchase.
Chinese medicine composition of the treatment osteoarthritis of the embodiment of the present invention and osteonecrosis and preparation method thereof is carried out below
It illustrates.
A kind of Chinese medicine composition for treating osteoarthritis and osteonecrosis, component include teasel root 20-40 according to parts by weight
It is part, 8-18 parts of Radix Salviae Miltiorrhizae, 8-18 parts of psoralea corylifolia, 8-18 parts of radix achyranthis bidentatae, 8-18 parts of corydalis tuber, 20-140 parts of Herba Epimedii, 8-18 parts of rhizoma anemarrhenae, ripe
8-18 parts of glutinous rehmannia and 8-18 parts of Cortex Eucommiae.
Wherein, teasel root, slightly warm in nature are bitter, pungent；Return liver and kidney channel.There is nourishing liver and kidney, strengthening the bones and muscles, continuous injured, stop metrorrhagia and metrostaxis
Effect can be used for treating the illnesss such as kidney deficiency and liver, soreness and weakness of waist and knees, rheumatic arthralgia, injury of tendon and muscle fracture, injury from falling down.Wherein prepared RADIX DIPSACI with yellow rice wine
It is chiefly used in rheumatic arthralgia, injury of tendon and muscle fracture, injury from falling down, prepared RADIX DIPSACI with salt solution is chiefly used in soreness and weakness of waist and knees.
The effect of Radix Salviae Miltiorrhizae has promoting blood circulation, inducing meastruation to relieve menalgia, relieving restlessness and restlessness, cool blood to disappear carbuncle.For chest impediment and cardialgia, stomach duct and abdomen
Hypochondriac pain, a lump in the abdomen causing distension and pain, hot numbness pain.
Psoralea corylifolia, seed are used as medicine, and have the function of tonifying kidney and strengthening yang, good efficacy to suffering from a deficiency of the kidney, and can control the skin diseases such as psoriasis；Pharmacological property:
It is bitter, pungent, warm.Return kidney, the spleen channel.Tonifying kidney and strengthening yang, retention of essence and urine, kidney deficiency and lumbago, kidney leakage, warming spleen and stopping diarrha, gas of receiving is relievingd asthma.
Radix achyranthis bidentatae, root are used as medicine, blood circulation；Nourishing liver and kidney, strong waist and knee；Control soreness of waist and knee joint, caused by liver and kidney deficiency, bruise stasis caused pain.By the stasis of blood
Promoting menstruation, nourishing liver and kidney, strengthening the bones and muscles, inducing diuresis for treating strangurtia are ensuringd proper downward flow of the blood.
Corydalis tuber is used as medicine with stem tuber, there is promoting blood circulation to remove blood stasis, and the effect of regulating qi-flowing for relieving pain cures mainly stomachache, dysmenorrhea, traumatic injury etc..
Herba Epimedii；Herba Epimedii herb hyoscine.Tonifying kidney and strengthening yang, dispelling wind and eliminating dampness.Cure mainly pain in low back and legs, numb limb, half body
It is unsuccessful, the diseases such as neurasthenia.
Rhizoma anemarrhenae, it is bitter in taste, it trembles with fear.Return lung, stomach, kidney channel.Effect, clearing heat-fire, nourishing Yin and moistening dryness.Cure mainly pyreticosis and polydipsia, lung heat
Cough caused by dryness, osteopyrexia and fever, Heat Diabetes, dry constipation of intestines.
Rehmannia glutinosa, sweet in flavor, slightly warm in nature have nourishing yin and supplementing blood, beneficial to spirit and marrow and other effects.Cure mainly the deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees,
The diseases such as osteopyrexia and fever, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation.
The effect of Cortex Eucommiae, Cortex Eucommiae have nourishing liver and kidney, control spinal column ache, foot and knee flaccidity, hypertension.Cortex Eucommiae to immune system,
Endocrine system, central nervous system, the circulatory system and urinary system have different degrees of adjustment effect, and Cortex Eucommiae excited can hang down
Body-interrenal system enhances adrenal cortex function.
Osteoarthritis and osteonecrosis, in tcm causa morbi, be due to kidney deficiency and liver, deficiency of qi and blood caused by, it is congenital it
Originally it is kidney, kidney storing essence, raw marrow, main bone, deficiency of kidney-essence, deficiency of kidney-QI, then bone is become homeless feeding；Muscle bone no hard, or be various congenital
Deformity.Liver is homologous with kidney, and master pulse, kidney qi was both lost, and liver is also insufficient.The spleen and stomach provide the material basis of the acquired, kidney yang virtual loss, cannot warm, promotion
Transporting and transforming function of the spleen and stomach, qi and blood lose in agitating and run sluggishness, cause stasis blocking obstructed eventually, QI-blood circulation is not normal, and several persons influence each other, and increasingly loses
Void meets various inducements, then Yi Fawei osteonecrosis.
Therefore, in the present embodiment, using teasel root and Herba Epimedii as monarch drug in a prescription, teasel root can nourishing liver and kidney, enhance muscles and bones, it is effectively slow
Solve injury of tendon and muscle fracture, the illnesss such as injury from falling down, and Herba Epimedii can tonifying kidney and strengthening yang, caused by alleviating by osteoarthritis or osteonecrosis
Pain in low back and legs, numb limb, the diseases such as hemiplegia.Rehmannia glutinosa and Cortex Eucommiae can further nourishing liver and kidney, with psoralea corylifolia and rhizoma anemarrhenae
Nourishing liver and kidney is taken into account, strong taste then carry out activating microcirculation and removing stasis medicinal with Radix Salviae Miltiorrhizae, radix achyranthis bidentatae and corydalis tuber, prevent the area of osteoarthritis and osteonecrosis
Domain stasis blocking is obstructed, and QI-blood circulation is normal.It cooperates between each component of the present embodiment, combines from internal cause and external cause with effective
Alleviate and treat the symptoms such as osteoarthritis and osteonecrosis.
Further, the component for treating the Chinese medicine composition of osteoarthritis and osteonecrosis includes teasel root according to parts by weight
25-35 parts, 10-15 parts of Radix Salviae Miltiorrhizae, 10-15 parts of psoralea corylifolia, 10-15 parts of radix achyranthis bidentatae, 10-15 parts of corydalis tuber, 25-135 parts of Herba Epimedii, rhizoma anemarrhenae
10-15 parts, 10-15 parts of Rehmannia glutinosa and 10-15 parts of Cortex Eucommiae.
Further, the component for treating the Chinese medicine composition of osteoarthritis and osteonecrosis includes teasel root 30 according to parts by weight
Part, 12 parts of Radix Salviae Miltiorrhizae, 12 parts of psoralea corylifolia, 12 parts of radix achyranthis bidentatae, 12 parts of corydalis tuber, 30 parts of Herba Epimedii, 12 parts of rhizoma anemarrhenae, 12 parts of Rehmannia glutinosa and Du
Secondary 12 parts.
Further, the component for treating the Chinese medicine composition of osteoarthritis and osteonecrosis includes teasel root 30 according to parts by weight
Part, 12 parts of Radix Salviae Miltiorrhizae, 12 parts of psoralea corylifolia, 12 parts of radix achyranthis bidentatae, 12 parts of corydalis tuber, 135 parts of Herba Epimedii, 12 parts of rhizoma anemarrhenae, 12 parts of Rehmannia glutinosa and
12 parts of Cortex Eucommiae.
In addition, present invention also provides a kind of preparation method of Chinese medicine composition for treating osteoarthritis and osteonecrosis,
Including above-mentioned treatment osteoarthritis and the component of the Chinese medicine composition of osteonecrosis are mixed tanning or granulation.
It that is to say, the Chinese medicine composition for the treatment of osteoarthritis and osteonecrosis in the present embodiment can be mixed tanning shape
At decoction, particle can also be formed with mixing granulation.
When preparation forms particulate matter, specifically includes the following steps:
S1, teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber are pulverized；
In the present embodiment, mixes, can also mix after teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber being crushed respectively
It crushes.
Wherein, 200-240 mesh is crossed after teasel root milling, crosses 160-180 mesh, Radix Salviae Miltiorrhizae, radix achyranthis bidentatae and corydalis tuber after psoralea corylifolia milling
100-120 mesh is crossed after milling.In the present embodiment, by controlling the milling mesh number of different pharmaceutical, to control the medicine of different pharmaceutical
Effect release and coating function.
When it is mixed and smashed, the mesh number of mixed powder is 100-120 mesh.
S2, Herba Epimedii, rhizoma anemarrhenae, Rehmannia glutinosa and Cortex Eucommiae are added water to cook repeatedly, collecting decoction is concentrated into thick paste；
The time added water to cook is each 1-2h.Thick paste is 1.35~1.38 relative to the relative density of water.
S3, the powder that teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber are added into thick paste, mixing granulation.
When mixed powder is by obtaining after teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber co-grinding, i.e., directly in thick paste
Interior addition mixed powder.
When mixed powder is crushed respectively by teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber, i.e., by being persistently separately added into.Specifically
Ground, the biggish Radix Salviae Miltiorrhizae of particle, radix achyranthis bidentatae and corydalis tuber, Radix Salviae Miltiorrhizae, radix achyranthis bidentatae and corydalis tuber are first added into thick paste to be uniformly mixed with thick paste,
Due to aqueous in thick paste, enable to the surface adhesion of Radix Salviae Miltiorrhizae, radix achyranthis bidentatae and corydalis tuber to have thick paste and partial moisture, benefit will be subsequently added into
Bone fat powder, Malaytea Scurfpea Fruit are further coated on the outside of thick paste, Radix Salviae Miltiorrhizae, radix achyranthis bidentatae and corydalis tuber, are subsequently added into Himalayan Teasel Root, continue
The particle of disconnected powder is small, is easy to be attached at the surface of material, while can further decrease the water content of material, by continuous
Be mixed, it is to be mixed uniformly after, through drying and granulating.
Preparation method provided in this embodiment is simple, can directly mixing and water adding be brewed into decoction, can also part medicine
Material crushes, the tanning of part medicinal material, last mixing granulation, our experiments show that, teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber are distinguished
It crushes, and is added in thick paste according to a graded, the effect of the Chinese medicine composition of the treatment osteoarthritis and osteonecrosis of acquisition is more
It is good.
With reference to embodiments to treatment osteoarthritis and the Chinese medicine composition of osteonecrosis and preparation method thereof of the invention
Further progress illustrates.
Embodiment 1
A kind of Chinese medicine composition for treating osteoarthritis and osteonecrosis is present embodiments provided, preparation method includes:
Stock: teasel root 20g, Radix Salviae Miltiorrhizae 8g, psoralea corylifolia 8g, radix achyranthis bidentatae 8g, corydalis tuber 8g, Herba Epimedii 20g, rhizoma anemarrhenae 8g, Rehmannia glutinosa 8g
And Cortex Eucommiae 8g；
Preparation: teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber are uniformly mixed, and it is mixed for 100 purposes to be then ground into mesh number
Powder is closed, Herba Epimedii, rhizoma anemarrhenae, Rehmannia glutinosa and Cortex Eucommiae are added water to cook three times, each 1h, collecting decoction is concentrated into relative density
For 1.35~1.38 thick paste, mixed powder, mixing granulation are added into thick paste.
Embodiment 2
A kind of Chinese medicine composition for treating osteoarthritis and osteonecrosis is present embodiments provided, preparation method includes:
Stock: teasel root 26g, Radix Salviae Miltiorrhizae 11g, psoralea corylifolia 11g, radix achyranthis bidentatae 11g, corydalis tuber 11g, Herba Epimedii 26g, rhizoma anemarrhenae 11g, radix rehmanniae preparata
Yellow 11g and Cortex Eucommiae 11g；
Preparation: teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber are uniformly mixed, and it is mixed for 120 purposes to be then ground into mesh number
Powder is closed, Herba Epimedii, rhizoma anemarrhenae, Rehmannia glutinosa and Cortex Eucommiae are added water to cook three times, each 2h, collecting decoction is concentrated into relative density
For 1.35~1.38 thick paste, mixed powder, mixing granulation are added into thick paste.
Embodiment 3
A kind of Chinese medicine composition for treating osteoarthritis and osteonecrosis is present embodiments provided, preparation method includes:
Stock: teasel root 30g, Radix Salviae Miltiorrhizae 12g, psoralea corylifolia 12g, radix achyranthis bidentatae 12g, corydalis tuber 12g, Herba Epimedii 30g, rhizoma anemarrhenae 12g, radix rehmanniae preparata
Yellow 12g and Cortex Eucommiae 12g；
Preparation: teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber are uniformly mixed, and it is mixed for 120 purposes to be then ground into mesh number
Powder is closed, Herba Epimedii, rhizoma anemarrhenae, Rehmannia glutinosa and Cortex Eucommiae are added water to cook three times, each 2h, collecting decoction is concentrated into relative density
For 1.37 thick paste, mixed powder, mixing granulation are added into thick paste.
Embodiment 4
A kind of Chinese medicine composition for treating osteoarthritis and osteonecrosis is present embodiments provided, preparation method includes:
Stock: teasel root 37g, Radix Salviae Miltiorrhizae 17g, psoralea corylifolia 17g, radix achyranthis bidentatae 17g, corydalis tuber 17g, Herba Epimedii 37g, rhizoma anemarrhenae 17g, radix rehmanniae preparata
Yellow 17g and Cortex Eucommiae 17g；
Preparation: teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber are uniformly mixed, and it is mixed for 100 purposes to be then ground into mesh number
Powder is closed, Herba Epimedii, rhizoma anemarrhenae, Rehmannia glutinosa and Cortex Eucommiae is added water to cook three times, each 1.5h, collecting decoction, is concentrated into relatively close
The thick paste that degree is 1.35~1.38, mixed powder, mixing granulation are added into thick paste.
Embodiment 5
The Chinese medicine composition for the treatment of osteoarthritis and osteonecrosis provided in this embodiment, amounts of components and embodiment 3 one
Sample, difference are that preparation method is different；
In the present embodiment, teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber are pulverized respectively, wherein after teasel root milling
220 meshes are crossed, 160 mesh are crossed after psoralea corylifolia milling, cross 100 mesh after Radix Salviae Miltiorrhizae, radix achyranthis bidentatae and corydalis tuber milling.
Herba Epimedii, rhizoma anemarrhenae, Rehmannia glutinosa and Cortex Eucommiae are added water to cook three times, each 2h, collecting decoction, is concentrated into relatively close
The thick paste that degree is 1.37.
The powder of Radix Salviae Miltiorrhizae, radix achyranthis bidentatae and corydalis tuber is first added into thick paste, is subsequently added into Malaytea Scurfpea Fruit, is subsequently added into teasel root powder
End, by being constantly mixed, it is to be mixed uniformly after, through drying and granulating.
Embodiment 6-7
The Chinese medicine composition for the treatment of osteoarthritis and osteonecrosis provided in this embodiment, substantially the same manner as Example 5, area
It is not, the mesh number of powder is different；
In embodiment 6,200 meshes are crossed after teasel root milling, and 160 mesh, Radix Salviae Miltiorrhizae, radix achyranthis bidentatae and corydalis tuber milling are crossed after psoralea corylifolia milling
100 mesh are crossed afterwards.
In embodiment 7,240 meshes are crossed after teasel root milling, and 180 mesh, Radix Salviae Miltiorrhizae, radix achyranthis bidentatae and corydalis tuber milling are crossed after psoralea corylifolia milling
120 mesh are crossed afterwards.
Embodiment 8
A kind of Chinese medicine composition for treating osteoarthritis and osteonecrosis is present embodiments provided, preparation method includes:
Stock: teasel root 20g, Radix Salviae Miltiorrhizae 8g, psoralea corylifolia 8g, radix achyranthis bidentatae 8g, corydalis tuber 8g, Herba Epimedii 140g, rhizoma anemarrhenae 8g, Rehmannia glutinosa 8g
And Cortex Eucommiae 8g；
Preparation: said components mixing and water adding is decocted three times, each 1h, collecting decoction to obtain the final product.
Embodiment 9-11
The Chinese medicine composition for the treatment of osteoarthritis and osteonecrosis provided in this embodiment, substantially the same manner as Example 8, area
It is not, amounts of components is different；
In embodiment 9, teasel root 26g, Radix Salviae Miltiorrhizae 11g, psoralea corylifolia 11g, radix achyranthis bidentatae 11g, corydalis tuber 11g, Herba Epimedii 120g, rhizoma anemarrhenae
11g, Rehmannia glutinosa 11g and Cortex Eucommiae 11g；
In embodiment 10, teasel root 30g, Radix Salviae Miltiorrhizae 12g, psoralea corylifolia 12g, radix achyranthis bidentatae 12g, corydalis tuber 12g, Herba Epimedii 135g, rhizoma anemarrhenae
12g, Rehmannia glutinosa 12g and Cortex Eucommiae 12g；
In embodiment 11, teasel root 37g, Radix Salviae Miltiorrhizae 17g, psoralea corylifolia 17g, radix achyranthis bidentatae 17g, corydalis tuber 17g, Herba Epimedii 140g, rhizoma anemarrhenae
17g, Rehmannia glutinosa 17g and Cortex Eucommiae 17g.
Test example 1
By the Chinese medicine composition of above-described embodiment 1-11 treatment osteoarthritis and osteonecrosis obtained, and in the prior art
Dexamethasone be control group, treat 100 patients (amounting to 1200 patients) respectively, through detecting, this 1200 patients are equal
With knee osteoarthritis.It is secondary for decoction daily one for particle daily one (every xxg).Effect recording is as follows:
| It cures | It is effective | Effectively | In vain | It is efficient | |
| Embodiment 1 | 52 | 31 | 11 | 6 | 94% |
| Embodiment 2 | 55 | 30 | 10 | 5 | 95% |
| Embodiment 3 | 62 | 23 | 12 | 3 | 97% |
| Embodiment 4 | 63 | 21 | 10 | 6 | 94% |
| Embodiment 5 | 66 | 21 | 11 | 2 | 98% |
| Embodiment 6 | 65 | 22 | 11 | 2 | 98% |
| Embodiment 7 | 67 | 21 | 11 | 1 | 99% |
| Embodiment 8 | 49 | 22 | 19 | 10 | 90% |
| Embodiment 9 | 53 | 25 | 13 | 9 | 91% |
| Embodiment 10 | 57 | 26 | 9 | 8 | 92% |
| Embodiment 11 | 50 | 27 | 14 | 9 | 91% |
| Control group | 56 | 19 | 10 | 15 | 85% |
As can be seen from the above table, the effective percentage of embodiment 1-11 is above comparative example, the especially effective percentage of embodiment 5-7
98% or more, therapeutic effect is prominent.
In conclusion the Chinese medicine composition for the treatment of osteoarthritis provided in this embodiment and osteonecrosis is with teasel root and Herba Epimedii
As monarch drug in a prescription, teasel root can nourishing liver and kidney, enhance muscles and bones, the illnesss such as injury of tendon and muscle fracture, injury from falling down be effectively relieved, and Herba Epimedii can
Tonifying kidney and strengthening yang is alleviated by pain in low back and legs caused by osteoarthritis or osteonecrosis, numb limb, the diseases such as hemiplegia.Rehmannia glutinosa
With Cortex Eucommiae can further nourishing liver and kidney, take into account nourishing liver and kidney, strong taste, then with Radix Salviae Miltiorrhizae, radix achyranthis bidentatae and member with psoralea corylifolia and rhizoma anemarrhenae
Activating microcirculation and removing stasis medicinal is carried out recklessly, prevents the region stasis blocking of osteoarthritis and osteonecrosis obstructed, QI-blood circulation is normal.The present embodiment it is each
It cooperates between component, combines from internal cause and external cause to be effectively relieved and treat the symptoms such as osteoarthritis and osteonecrosis.In addition,
The preparation method of offer is simple, can directly mixing and water adding be brewed into decoction, can also part pulverizing medicinal materials, part medicinal material endures
System, last mixing granulation, our experiments show that, teasel root, Radix Salviae Miltiorrhizae, psoralea corylifolia, radix achyranthis bidentatae and corydalis tuber are crushed respectively, and according to certain time
Sequence is added in thick paste, the better effect of the Chinese medicine composition of the treatment osteoarthritis and osteonecrosis of acquisition.
These are only the preferred embodiment of the present invention, is not intended to restrict the invention, for those skilled in the art
For member, the invention may be variously modified and varied.All within the spirits and principles of the present invention, it is made it is any modification,
Equivalent replacement, improvement etc., should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of Chinese medicine composition for treating osteoarthritis and osteonecrosis, which is characterized in that its component includes according to parts by weight
20-40 parts of teasel root, 8-18 parts of Radix Salviae Miltiorrhizae, 8-18 parts of psoralea corylifolia, 8-18 parts of radix achyranthis bidentatae, 8-18 parts of corydalis tuber, 20-140 parts of Herba Epimedii, rhizoma anemarrhenae
8-18 parts, 8-18 parts of Rehmannia glutinosa and 8-18 parts of Cortex Eucommiae.
2. the Chinese medicine composition for the treatment of osteoarthritis and osteonecrosis according to claim 1, which is characterized in that its component is pressed
Parts by weight meter include 25-35 parts of teasel root, 10-15 parts of Radix Salviae Miltiorrhizae, 10-15 parts of psoralea corylifolia, 10-15 parts of radix achyranthis bidentatae, 10-15 parts of corydalis tuber,
25-135 parts of Herba Epimedii, 10-15 parts of rhizoma anemarrhenae, 10-15 parts of Rehmannia glutinosa and 10-15 parts of Cortex Eucommiae.
3. the Chinese medicine composition for the treatment of osteoarthritis and osteonecrosis according to claim 2, which is characterized in that its component is pressed
Parts by weight meter includes 30 parts of teasel root, 12 parts of Radix Salviae Miltiorrhizae, 12 parts of psoralea corylifolia, 12 parts of radix achyranthis bidentatae, 12 parts of corydalis tuber, 30 parts of Herba Epimedii, rhizoma anemarrhenae
12 parts, 12 parts of Rehmannia glutinosa and 12 parts of Cortex Eucommiae.
4. the Chinese medicine composition for the treatment of osteoarthritis and osteonecrosis according to claim 2, which is characterized in that its component is pressed
Parts by weight meter includes 30 parts of teasel root, 12 parts of Radix Salviae Miltiorrhizae, 12 parts of psoralea corylifolia, 12 parts of radix achyranthis bidentatae, 12 parts of corydalis tuber, 135 parts of Herba Epimedii, rhizoma anemarrhenae
12 parts, 12 parts of Rehmannia glutinosa and 12 parts of Cortex Eucommiae.
5. a kind of preparation method for the Chinese medicine composition for treating osteoarthritis and osteonecrosis, which is characterized in that it includes by right
It is required that the component mixing tanning or granulation of the Chinese medicine composition of the described in any item treatment osteoarthritis of 1-4 and osteonecrosis.
6. the preparation method of the Chinese medicine composition for the treatment of osteoarthritis according to claim 5 and osteonecrosis, feature exist
In the teasel root, the Radix Salviae Miltiorrhizae, the psoralea corylifolia, the radix achyranthis bidentatae and the corydalis tuber being pulverized, by the Herba Epimedii, institute
It states rhizoma anemarrhenae, the Rehmannia glutinosa and the Cortex Eucommiae to add water to cook repeatedly, collecting decoction, is concentrated into thick paste, adds in Xiang Suoshu thick paste
Enter the powder of the teasel root, the Radix Salviae Miltiorrhizae, the psoralea corylifolia, the radix achyranthis bidentatae and the corydalis tuber, mixing granulation.
7. the preparation method of the Chinese medicine composition for the treatment of osteoarthritis according to claim 6 and osteonecrosis, feature exist
In the teasel root crosses 200-240 mesh after being milled, cross 160-180 mesh, the Radix Salviae Miltiorrhizae, the radix achyranthis bidentatae after the psoralea corylifolia milling
100-120 mesh is crossed with after corydalis tuber milling.
8. the preparation method of the Chinese medicine composition for the treatment of osteoarthritis according to claim 6 and osteonecrosis, feature exist
In the thick paste is 1.35~1.38 relative to the relative density of water.
9. the preparation method of the Chinese medicine composition for the treatment of osteoarthritis according to claim 6 and osteonecrosis, feature exist
In the time added water to cook is each 1-2h.
10. the preparation method of the Chinese medicine composition for the treatment of osteoarthritis according to claim 6 and osteonecrosis, feature exist
In the first powder that the Radix Salviae Miltiorrhizae, the radix achyranthis bidentatae and the corydalis tuber are added into the thick paste is subsequently added into the powder of the psoralea corylifolia
End is subsequently added into the powder of the teasel root.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1742934A (en) * | 2005-09-29 | 2006-03-08 | 余世春 | Xianlinggubao granulae preparation, and preparing method and quality control technology |
| CN1781535A (en) * | 2005-04-28 | 2006-06-07 | 贵州同济堂制药股份有限公司 | Medicine for treating osteoporosis and its preparing method and use |
| CN102327380A (en) * | 2011-10-22 | 2012-01-25 | 李进峰 | Chinese medicinal composition for treating knee osteoarthritis |
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- 2018-12-19 CN CN201811560786.7A patent/CN109394955A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1781535A (en) * | 2005-04-28 | 2006-06-07 | 贵州同济堂制药股份有限公司 | Medicine for treating osteoporosis and its preparing method and use |
| CN1742934A (en) * | 2005-09-29 | 2006-03-08 | 余世春 | Xianlinggubao granulae preparation, and preparing method and quality control technology |
| CN102327380A (en) * | 2011-10-22 | 2012-01-25 | 李进峰 | Chinese medicinal composition for treating knee osteoarthritis |
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Application publication date: 20190301 |