CN109369519B - 一种2-氯-3-氰基吡啶的绿色制备方法 - Google Patents
一种2-氯-3-氰基吡啶的绿色制备方法 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
本发明公开了一种2‑氯‑3‑氰基吡啶的绿色制备方法,包括以下步骤:以3‑氰基吡啶N‑氧化物为原料,将其溶在一定量的有机溶剂中,加入添加剂、有机碱与相转移催化剂,形成原料体系,控制适宜的温度,然后将双(三氯甲基)碳酸酯溶解到一定量的有机溶剂中,缓慢滴加到原料体系中进行反应,反应完毕经简单处理即可得到2‑氯‑3‑氰基吡啶。本发明制备方法简单,反应周期短,使用绿色的氯化试剂代替含磷试剂,无重金属参与,与现有的技术相比,环境污染小,操作安全,成本低廉,适宜工业化生产。本方法应用于3‑氰基吡啶N‑氧化物的绿色氯化反应,但不局限于2‑氯‑3‑氰基吡啶的制备。
Description
技术领域
本发明属于有机中间体合成领域,具体涉及一种2-氯-3-氰基吡啶的绿色制备方法。
背景技术
2-氯-3-氰基吡啶是医药工业中常见的重要中间体,其用途广泛,可以其为原料合成众多性能优良的药物,例如抗抑郁药米氮平,抗艾滋病药物奈韦拉平,同时还具有消炎止痛,治疗消耗综合症等功效,也可以其为原料合成农用化学品,以用于提高饲料蛋白的利用率,同时还可以用作杀虫剂和除草剂。
现有的2-氯-3-氰基吡啶合成路线有很多,其中一条是以3-氰基吡啶N-氧化物为原料,与氯化试剂进行反应,所用的氯化试剂大多以三氯氧磷、五氯化磷、二氯亚砜以及磺酰氯为主,主要存在以下不足:(1)使用POCl3作为氯化剂在回流条件下直接氯化,或增添PCl5加速反应,使用的氯化剂摩尔量不仅是原料摩尔量的3倍以上,并且产生了大量难以处理的含磷废水与废酸。(2)使用二氯亚砜及磺酰氯作为氯化试剂,会产生较多2位羟基取代的副产物以及大量的二氧化硫气体,具有较低反应选择性和反应收率。
专利JP8217753报道用双(三氯甲基)碳酸酯取代三氯氧磷做氯化试剂进行反应,收率仅为43%;专利CN101659637(A)在此基础上进行条件优化,报道收率在50%~85%;专利CN101941943(A)通过双(三氯甲基)碳酸酯与取代酰胺反应,先制得Vilsmeier试剂,然后在高温条件下对底物进行氯化,报道收率基本在80%以上(纯度>98%)。按照专利CN101941943(A)报道的方式进行实验,未得到理想收率;在专利CN101659637(A)基础上,通过加入添加剂和相转移催化剂以及反应条件筛选,最终收率稳定提高至90%以上。且相比原有氯化方式,反应条件更加温和。
此制备方法采用绿色有机合成试剂双(三氯甲基)碳酸酯做氯化试剂,符合环保要求;而且工艺简单,操作方便,减少工业生产2-氯3-氰基吡啶及类似物带来的环境污染。
发明内容
本发明克服了现有合成2-氯-3-氰基吡啶技术存在的上述缺陷,提出了一种环境较为友好的2-氯-3-氰基吡啶的制备方法,用双(三氯甲基)碳酸酯作为氯化试剂,与3-氰基吡啶N-氧化物反应,在添加剂以及相转移催化剂的作用下,大大提高反应收率,同时极大程度上降低原有技术路线对环境造成的污染。
本发明以3-氰基吡啶N-氧化物为原料,制备2-氯-3-氰基吡啶,包括以下步骤:
首先在有机溶剂中溶解3-氰基吡啶N-氧化物,于-5℃~10℃下加入有机碱;控制体系温度在-10~-5℃,加入添加剂与相转移催化剂;继续降温,在-15~-10℃下缓慢滴加溶于有机溶剂的双(三氯甲基)碳酸酯溶液,并于-15℃~60℃下反应2~16h。
上述反应过程如下式所示:
所述分离提纯过程可按照本领域常规方法进行,具体如下:反应结束后,加入少许水淬灭、分层萃取、有机层依次碱洗、水洗、萃取、脱色、干燥,浓缩得产物2-氯-3-氰基吡啶。
使用的溶剂为1,2-二氯乙烷、二氯甲烷、甲苯、1,4-二氧六环、乙腈、四氢呋喃、石油醚中的一种,优选为1,2-二氯乙烷。
使用的有机碱为三乙胺,N,N-二甲基甲酰胺、吡啶中的一种,优选为三乙胺。
使用的添加剂为氯化钠、氯化钾、氯化铝、亚硫酸钠、硫代硫酸钠、连二亚硫酸钠中的一种或多种,优选为氯化钠与亚硫酸钠的组合,此时,3-氰基吡啶N-氧化物与氯化钠的摩尔比为1:0.5~1;3-氰基吡啶N-氧化物与亚硫酸钠的摩尔比为1:0.01~0.05,此时,反应收率可以稳定地达到90%以上。
为得到较多目标产品,避免原料及氯化试剂浪费,作为优选,所用3-氰基吡啶N-氧化物与双(三氯甲基)碳酸酯及有机碱的摩尔比为1:0.4~1:1.5~3.5,所用溶剂与3-氰基吡啶N-氧化物的重量比为5~20:1。
本发明中,所述的3-氰基吡啶N-氧化物和相转移催化剂的摩尔比为1:0.01~0.04
本发明与现有技术相比具有以下优点:
(1)双(三氯甲基)碳酸酯是一种较安全的氯化试剂,利用其代替二氯亚砜、磺酰氯,三氯氧磷、五氯化磷等可避免二氧化硫、含磷废水等高污染物的生成,对环境影响小。
(2)工艺简单,反应条件相对于已有方法较温和,且后处理方便,最终产品纯度和收率高,适合工业化生产。
附图说明
图1为本发明具体实施例1中所得产品2-氯-3氰基吡啶的氢核磁谱图(1H-NMR),核磁数据如下:1H NMR(500MHz,DMSO)δ8.70(dd,J=4.9,1.9Hz,1H),8.47(dd,J=7.8,1.9Hz,1H),7.65(dd,J=7.8,4.9Hz,1H).
具体实施方式
实施例1
取一干燥的四口烧瓶,搭好尾气吸收装置,加入15g(125mmol)3-氰基吡啶N-氧化物及110mL1,2-二氯乙烷,在0℃的低温条件下搅拌成均质溶液,当T=-5~0℃时,加入25.30g(250mmol)三乙胺,继续降温,加入3.50g(62.5mmol)氯化钠,0.78g(6.25mmol)亚硫酸钠,1.13g(5mmol)苄基三乙基氯化铵,继续冷却至-15℃,开始缓慢滴加60mL含18.52g(62.5mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,于该温度下保温反应16小时,反应完毕,滴加40mL去离子水搅拌淬灭。分层,有机相用60mL10%的氢氧化钠溶液洗涤,再用60mL去离子水洗涤,最后用(60mL*2)1,2-二氯乙烷萃取水相,合并有机层,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机相用无水硫酸镁干燥后,脱除溶剂,粗产物打浆,烘干后,得16.30g红褐色产物,收率94.15%。
实施例2
取一干燥的四口烧瓶,搭好尾气吸收装置,加入15g(125mmol)3-氰基吡啶N-氧化物及110mL1,2-二氯乙烷,在0℃的低温条件下搅拌成均质溶液,当T=-5~0℃时,加入31.63g(312.5mmol)三乙胺,继续降温,加入1.83g(31.25mmol)氯化钠,0.78g(6.25mmol)亚硫酸钠,1.13g(5mmol)苄基三乙基氯化铵,继续冷却至-15℃,开始缓慢滴加60mL含18.52g(62.5mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,于该温度下保温反应16小时,反应完毕,滴加40mL去离子水搅拌淬灭。分层,有机相用60mL10%的氢氧化钠溶液洗涤,再用60mL去离子水洗涤,最后用(60mL*2)1,2-二氯乙烷萃取水相,合并有机层,加入活性炭于60℃下回流脱色一小时,脱色完毕,过滤,有机相用无水硫酸镁干燥后,脱除溶剂,粗产物打浆,烘干后,得13.74g红褐色产物,收率79.36%。
实施例3
取一干燥的四口烧瓶,搭好尾气吸收装置,加入15g(125mmol)3-氰基吡啶N-氧化物及110mL1,2-二氯乙烷,在0℃的低温条件下搅拌成均质溶液,当T=-5~0℃时,加入31.63g(312.5mmol)三乙胺,继续降温,加入3.50g(62.5mmol)氯化钠,0.78g(6.25mmol)亚硫酸钠,1.13g(5mmol)苄基三乙基氯化铵,继续冷却至-15℃,开始缓慢滴加60mL含18.52g(62.5mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,于该温度下保温反应15小时,反应完毕,滴加40mL去离子水搅拌淬灭。分层,有机相用60mL10%的氢氧化钠溶液洗涤,再用60mL去离子水洗涤,最后用(60mL*2)1,2-二氯乙烷萃取水相,合并有机层,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,用无水硫酸镁干燥后,脱除溶剂,粗产物打浆,烘干后,得14.76g红褐色产物,收率85.26%。
实施例4
取一干燥的四口烧瓶,搭好尾气吸收装置,加入15g(125mmol)3-氰基吡啶N-氧化物及110mL1,2-二氯乙烷,在0℃的低温条件下搅拌成均质溶液,当T=-5~0℃时,加入37.95g(375mmol)三乙胺,继续降温,加入1.83g(31.25mmol)氯化钠,0.78g(6.25mmol)亚硫酸钠,1.13g(5mmol)苄基三乙基氯化铵,继续冷却至-15℃,开始缓慢滴加100mL含29.63g(100mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,于该温度下保温反应4小时,反应完毕,滴加40mL去离子水搅拌淬灭。分层,有机相用60mL10%的氢氧化钠溶液洗涤,再用60mL去离子水洗涤,最后用(60mL*2)1,2-二氯乙烷萃取水相,合并有机层,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机相用无水硫酸镁干燥后,脱除溶剂,粗产物打浆,烘干后,得14.85g红褐色产物,收率85.76%。
实施例5
取一干燥的四口烧瓶,搭好尾气吸收装置,加入15g(125mmol)3-氰基吡啶N-氧化物及110mL1,2-二氯乙烷,在0℃的低温条件下搅拌成均质溶液,当T=-5~0℃时,加入37.95g(375mmol)三乙胺,继续降温,加入1.83g(31.25mmol)氯化钠,0.78g(6.25mmol)亚硫酸钠,1.13g(5mmol)苄基三乙基氯化铵,继续冷却至-15℃,开始缓慢滴加120mL含37.03g(125mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,于该温度下保温反应3小时,反应完毕,滴加40mL去离子水搅拌淬灭。分层,有机相用60mL10%的氢氧化钠溶液洗涤,再用60mL去离子水洗涤,最后用(60mL*2)1,2-二氯乙烷萃取水相,合并有机层,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机相用无水硫酸镁干燥后,脱除溶剂,粗产物打浆,烘干后,得13.52g红褐色产物,收率78.10%。
实施例6
取一干燥的四口烧瓶,搭好尾气吸收装置,加入15g(125mmol)3-氰基吡啶N-氧化物及110mL1,2-二氯乙烷,在0℃的低温条件下搅拌成均质溶液,当T=-5~0℃时,加入37.95g(375mmol)三乙胺,继续降温,加入1.83g(31.25mmol)氯化钠,0.78g(6.25mmol)亚硫酸钠,1.13g(5mmol)苄基三乙基氯化铵,继续冷却至-15℃,开始缓慢滴加120mL含37.03g(125mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,升温至60℃,并在该温度下保温反应10小时,反应完毕,滴加40mL去离子水搅拌淬灭。分层,有机相用60mL10%的氢氧化钠溶液洗涤,再用60mL去离子水洗涤,最后用(60mL*2)1,2-二氯乙烷萃取水相,合并有机层,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机层用无水硫酸镁干燥后,脱除溶剂,粗产物打浆,烘干后,得14.58g红黑色产物,收率84.22%。
实施例7
取一干燥的四口烧瓶,搭好尾气吸收装置,加入2.40g(20mmol)3-氰基吡啶N-氧化物,7.00g(23.4mmol)双(三氯甲基)碳酸酯及25mL石油醚,并于0℃下滴加30mL含7.08g(70mmol)三乙胺的石油醚溶液,滴加完毕,升温至60℃,并在该温度下保温反应4小时,反应完毕,冷却至室温,依次用20mL去离子水洗涤,再用20mL10%的碳酸氢钠溶液洗涤。分层,收集有机相,加入活性碳,于60℃下回流脱色一小时,脱色完毕,过滤,有机层用无水硫酸镁干燥后,脱除溶剂,得1.46g砖红色产物,收率52.3%。
实施例8
取一干燥的四口烧瓶,搭好尾气吸收装置,加入6g(50mmol)3-氰基吡啶N-氧化物,7.60g(75mmol)三乙胺及40mL1,2-二氯乙烷,并于-15℃下滴加25mL含7.40g(25mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,并在该温度下保温反应2小时,反应完毕,升温至室温,加少许水淬灭后,分层,依次用20mL10%的碳酸氢钠溶液洗涤,再用20mL去离子水洗涤。分层,收集有机相,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机层用无水硫酸镁干燥后,脱除溶剂,得5.07g砖红色产物,收率73.21%。
实施例9
取一干燥的四口烧瓶,搭好尾气吸收装置,加入12g(100mmol)3-氰基吡啶N-氧化物,20.24g(200mmol)三乙胺及100mL1,2-二氯乙烷,并于-10℃下滴加60mL含17.78g(60mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,并在该温度下保温反应4小时,反应完毕,升温至室温,加少许水淬灭后,分层,依次用25mL10%的碳酸氢钠溶液洗涤,再用40mL去离子水洗涤。分层,收集有机相,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机层用无水硫酸镁干燥后,脱除溶剂,得11.83g红色产物,收率85.40%。
实施例10
取一干燥的四口烧瓶,搭好尾气吸收装置,加入6g(50mmol)3-氰基吡啶N-氧化物,7.60g(75mmol)三乙胺及40mL二氯甲烷,并于-15℃下滴加25mL含7.40g(25mmol)双(三氯甲基)碳酸酯的二氯甲烷溶液,滴加完毕,并在该温度下保温反应2小时,反应完毕,升温至室温,加少许水淬灭后,分层,依次用20mL10%的碳酸氢钠溶液洗涤,再用20mL去离子水洗涤。分层,收集有机相,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机层用无水硫酸镁干燥后,脱除溶剂,得4.87g砖红色产物,收率70.32%。
实施例11
取一干燥的四口烧瓶,搭好尾气吸收装置,加入6g(50mmol)3-氰基吡啶N-氧化物,7.60g(75mmol)三乙胺及40mL四氢呋喃,并于-15℃下滴加25mL含7.40g(25mmol)双(三氯甲基)碳酸酯的四氢呋喃溶液,滴加完毕,并在该温度下保温反应2小时,反应完毕,升温至室温,加少许水淬灭后,分层,依次用20mL10%的碳酸氢钠溶液洗涤,再用20mL去离子水洗涤。分层,收集有机相,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,用无水硫酸镁干燥后,脱除溶剂,得3.58g砖红色产物,收率51.70%。
实施例12
取一干燥的四口烧瓶,搭好尾气吸收装置,加入6g(50mmol)3-氰基吡啶N-氧化物,7.60g(75mmol)三乙胺及40mL甲苯,并于-15℃下滴加25mL含7.40g(25mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,升温至60℃,并在该温度下保温反应2小时,反应完毕,降温至室温,加少许水淬灭后,分层,依次用20mL10%的碳酸氢钠溶液洗涤,再用20mL去离子水洗涤。分层,收集有机相,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机相用无水硫酸镁干燥后,脱除溶剂,得4.52g红色产物,收率65.27%。
实施例13
取一干燥的四口烧瓶,搭好尾气吸收装置,加入6g(50mmol)3-氰基吡啶N-氧化物,9.93g(75mmol)吡啶及40mL1,2-二氯乙烷,并于-15℃下滴加25mL含7.40g(25mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,并在该温度下保温反应2小时,反应完毕,升温至室温,加少许水淬灭后,分层,依次用20mL10%的氢氧化钠溶液洗涤,再用20mL去离子水洗涤。分层,收集有机相,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机相用无水硫酸镁干燥后,脱除溶剂,得2.98g红褐色产物,收率43.03%。
实施例14
取一干燥的四口烧瓶,搭好尾气吸收装置,加入6g(50mmol)3-氰基吡啶N-氧化物,5.06g(50mmol)三乙胺及40mL1,2-二氯乙烷,当温度降至0℃后,加入0.56g(2mmol)四丁基氯化铵及5.85g(100mmol)氯化钠,并于-10℃下滴加25mL含7.41g(25mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,并在该温度下保温反应2小时,之后升温至60℃反应2小时,反应结束,降至室温,加少许水淬灭后,分层,依次用20mL10%的氢氧化钠溶液洗涤,再用20mL去离子水洗涤。分层,收集有机相,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机相用无水硫酸镁干燥后,脱除溶剂,得4.47g淡红褐色产物,收率64.52%。
实施例15
取一干燥的四口烧瓶,搭好尾气吸收装置,加入6g(50mmol)3-氰基吡啶N-氧化物,12.65g(125mmol)三乙胺及40mL1,2-二氯乙烷,当温度降至0℃后,加入1.09g(8mmol)三氯化铝,并于-10℃下滴加40mL含11.85g(40mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,并在该温度下保温反应半小时小时,之后升温至40℃反应5小时,反应结束,降至室温,加少许水淬灭后,分层,依次用20mL10%的碳酸氢钠溶液洗涤,再用20mL去离子水洗涤。分层,收集有机相,并用(25mL*2)1,2-二氯乙烷萃取水相,合并有机相,加入活性炭于60℃下回流脱色一小时,脱色完毕,过滤,有机相用无水硫酸镁干燥后,脱除溶剂,得5.14g白褐色产物,收率74.17%。
实施例16
取一干燥的四口烧瓶,搭好尾气吸收装置,加入6g(50mmol)3-氰基吡啶N-氧化物,12.65g(125mmol)三乙胺及50mL1,2-二氯乙烷,当温度降至0℃后,加入0.63g(2mmol)苄基三乙基氯化铵及2.93g(50mmol)氯化钠,并于-10℃下滴加50mL含14.84g(50mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,并在该温度下保温反应2小时,反应结束,加入40mL去离子水淬灭,分层,有机相依次用20mL10%的氢氧化钠溶液洗涤,再用20mL去离子水洗涤。分层,收集有机相,并用(25mL*2)1,2-二氯乙烷萃取水相,合并有机相,加入活性炭于60℃下回流脱色一小时,脱色完毕,过滤,用无水硫酸镁干燥后,脱除溶剂,得6.33g酒红色产物,收率91.41%。
实施例17
取一干燥的四口烧瓶,搭好尾气吸收装置,加入12g(100mmol)3-氰基吡啶N-氧化物,25.30g(250mmol)三乙胺及90mL1,2-二氯乙烷,当温度降至0℃后,加入2.13g(16mmol)三氯化铝,并于-10℃下滴加90mL含29.68g(100mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,并在该温度下保温反应2小时,反应结束,加入80mL去离子水淬灭,分层,有机相依次用100mL10%的氢氧化钠溶液洗涤,再用100mL去离子水洗涤。分层,收集有机相,并用(60mL*2)1,2-二氯乙烷萃取水相,合并有机相,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机相用无水硫酸镁干燥后,脱除溶剂,得11.60g红黑色产物,收率74.11%。
实施例18
取一干燥的四口烧瓶,搭好尾气吸收装置,加入6g(50mmol)3-氰基吡啶N-氧化物,7.59g(75mmol)三乙胺及50mL1,2-二氯乙烷,当温度降至0℃后,加入1.26g(10mmol)亚硫酸钠,并于-10℃下滴加50mL含14.81g(50mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,并在该温度下保温反应4小时,反应结束,加入50mL去离子水淬灭,分层,有机相依次用20mL10%的氢氧化钠溶液洗涤,再用20mL去离子水洗涤。分层,收集有机相,并用(25mL*2)1,2-二氯乙烷萃取水相,合并有机相,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机层用无水硫酸镁干燥后,脱除溶剂,得4.54g白褐色产物,收率65.56%。
实施例19
取一干燥的四口烧瓶,搭好尾气吸收装置,加入6g(50mmol)3-氰基吡啶N-氧化物,12.65g(125mmol)三乙胺及50mL1,2-二氯乙烷,当温度降至0℃后,加入0.63g(5mmol)亚硫酸钠及0.67g(5mmol)三氯化铝,并于-10℃下滴加50mL含14.81g(50mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,并在该温度下保温反应3小时,反应结束,加入40mL去离子水淬灭,分层,有机相依次用40mL10%的氢氧化钠溶液洗涤,再用40mL去离子水洗涤。分层,收集有机相,并用(30mL*2)1,2-二氯乙烷萃取水相,合并有机相,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机相用无水硫酸镁干燥后,脱除溶剂,得4.99g砖红色产物,收率72.12%。
实施例20
取一干燥的四口烧瓶,搭好尾气吸收装置,加入12g(100mmol)3-氰基吡啶N-氧化物,25.30g(250mmol)三乙胺及90mL1,2-二氯乙烷,当温度降至0℃后,加入1.29g(4mmol)苄基三乙基氯化铵及5.84g(100mmol)氯化钠,并于-5℃下滴加100mL含29.63g(100mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,并在该温度下保温反应3小时,反应结束,加入40mL去离子水淬灭,分层,有机相依次用20mL10%的氢氧化钠溶液洗涤,再用20mL去离子水洗涤。分层,收集有机相,并用(25mL*2)1,2-二氯乙烷萃取水相,合并有机相,加入活性炭,于60℃下回流脱色一小时,脱色完毕,过滤,有机相用无水硫酸镁干燥后,脱除溶剂,得11.92g褐色产物,收率86.3%。
实施例21
取一干燥的四口烧瓶,搭好尾气吸收装置,加入6g(50mmol)3-氰基吡啶N-氧化物,12.65g(125mmol)三乙胺及50mL1,2-二氯乙烷,当温度降至0℃后,加入0.63g(2mmol)苄基三乙基氯化铵及0.63g(5mmol)亚硫酸钠,并于-15℃下滴加50mL含14.84g(50mmol)双(三氯甲基)碳酸酯的1,2-二氯乙烷溶液,滴加完毕,并在该温度下保温反应5小时,反应结束,加入40mL去离子水淬灭,分层,有机相依次用30mL10%的氢氧化钠溶液洗涤,再用30mL去离子水洗涤。分层,收集有机相,并用(40mL*2)1,2-二氯乙烷萃取水相,合并有机相,加入活性炭于60℃下回流脱色一小时,脱色完毕,过滤,有机相用无水硫酸镁干燥后,脱除溶剂,得5.83g褐色产物,收率84.20%。
实施例1~21中所得目标产品经核磁数据、熔点数据检测,与已报道文献中2-氯-3-氰基吡啶基本一致。
熔点:106.0℃-106.3℃。
Claims (2)
1.一种2-氯-3-氰基吡啶的绿色制备方法,其特征在于,包括:
在有机溶剂中加入3-氰基吡啶N-氧化物,于-5℃~10℃下加入有机碱;控制体系温度在-10~-5 ℃,加入添加剂与相转移催化剂;继续降温,在-15~-10 ℃下缓慢滴加溶于有机溶剂的双(三氯甲基)碳酸酯溶液,并于-15℃~60℃下反应2~16 h;反应完毕,经过淬灭、洗涤、萃取、脱色、干燥,浓缩得产物2-氯-3-氰基吡啶;
所述有机碱为三乙胺;
所述添加剂为氯化钠与亚硫酸钠的组合;
3-氰基吡啶N-氧化物与氯化钠的摩尔比为1:0.5~1;3-氰基吡啶N-氧化物与亚硫酸钠的摩尔比为1:0.01~0.05;
所述3-氰基吡啶N-氧化物、双(三氯甲基)碳酸酯、有机碱的摩尔比为1:0.4~1.0:1.2~3.5;
所述有机溶剂为1,2-二氯乙烷;
所述相转移催化剂为苄基三乙基氯化铵。
2.根据权利要求1所述的2-氯-3-氰基吡啶的绿色制备方法,其特征在于,所述有机溶剂与3-氰基吡啶N-氧化物质量比为5~20:1。
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