CN109364163A - A kind of Chinese materia medica preparation and preparation method thereof with hypolipemic function - Google Patents

Abstract

The present invention relates to pharmaceutics of Chinese drugs field more particularly to a kind of Chinese materia medica preparations and preparation method thereof with hypolipemic function.The present invention provides the Chinese materia medica preparation with hypolipemic function, is made of the raw material of following parts by weight: 5-15 parts of Radix Notoginseng, 5-15 parts of hawthorn, 5-15 parts of rhizoma alismatis, 5-15 parts of cassia seed, 5-15 parts of mulberry leaf, 5-15 parts of banana skin, 5-15 parts of safflower, 5-15 parts of ganoderma lucidum, 5-15 parts of the tuber of multiflower knotweed, 5-15 parts of pueraria lobata, 5-15 parts of Radix Glycyrrhizae.Chinese materia medica preparation of the invention is using Chinese herbal medicine as primary raw material, and low raw-material cost, preparation is convenient to take, practical, with strong points, can effective reducing blood lipid, and toxic side effect is small.

Description

A kind of Chinese materia medica preparation and preparation method thereof with hypolipemic function

Technical field

The present invention relates to pharmaceutics of Chinese drugs field more particularly to a kind of Chinese materia medica preparations and its preparation with hypolipemic function Method.

Background technique

Blood lipid, refers to the general name of contained lipid in blood, including neutral fat (triglycerides and cholesterol) and lipoid (Gu Alcohol, phosphatide, glycolipid, steroids), main component is triglycerides and cholesterol, and triglycerides participates in human body energy metabolism, and gallbladder is solid Alcohol is mainly used for synthetic cell serous coat, steroid hormone and bile acid.Under normal circumstances, most blood lipids can be penetrated into from endarterium Arterial wall, then be discharged from adventitial lymphatic vessel, it will not be deposited on arterial wall.Normal person's fasting plasma lipid value (mg/lOOmL) Are as follows: triglycerides 20-110, cholesterol and its ester 110-220 (cholesterol accounts for 70%-75%), phosphatidase 1 10-120.It is clinically high Pionemia refers to that triglycerides is higher than 130-150mg/mL, and cholesterol is higher than 220-230mg/mL.Cholesterol can also be with lipoprotein shape At compound, common lipoprotein has high-density lipoprotein, low-density lipoprotein, polar region density lipoprotein.High-density lipoprotein Protein body is small, and protein content is high, can form compound with the cholesterol on arterial wall, its antiport is made into liver It is excreted, and reduces its deposition on arterial wall, therefore one high-density lipoprotein cholesterol of this compound is also referred to as " good cholesterol ".And low-density lipoprotein molecule is small, cholesterol level highest, can by liver synthesize cholesterol transport to move The low-density lipoprotein of arteries and veins, excessive level can transport excessive cholesterol, cause cholesterol in the accumulation of arterial wall, to cause The arterial diseases such as artery sclerosis, also muscle infarction, therefore low density lipoprotein cholesterol is also known as " bad cholesterol ".Extra-low density rouge Albumen is synthesized by liver, and 80%-90% is triglycerides, is the important form for transporting endogenous triglycerides, and content increases When, triglycerides also necessarily increases.Therefore, the definition of hyperlipidemia is are as follows: blood fat disorder or dyslipidemia refer to blood in human body The concentration level of fat eliminating matter has exceeded normal scope, including the horizontal liter of serum total cholesterol (total cholesterol, TC) High, the horizontal raising of the sweet triglycerides of serum (triacylglycerols, TG), serum High Density Lipoprotein Cholesterol (high- Density lipoprotein cholesterol, HDL-C) reduced levels.

Hyperlipemia is to lead to the primary hazard factor of atherosclerotic vascular disease, and in addition high fat of blood can also cause A series of complication being detrimental to health.According to recent statistics, China is there are about 2.1 hundred million dyslipidemia crowds at present, and 88,000,000 Hyperlipidemia patient.The awareness of China's hyperlipidemia, treatment rate, control rate are only are as follows: 21%, 8.1% and 2.8%.It is annual tens of thousands of Life loses life because of high fat of blood, it severely compromises China's human health, and the common reducing blood lipid in market at present Drug generally has stronger side effect, so the blood lipid-lowering medicine or health food of exploitation Nantural non-toxic side effect, do not allow at quarter It is slow.

Hyperlipidemia, clinical manifestation, biochemistry without this name of disease in Chinese medicine ancient literature, according to modern medicine to hyperlipemia The understanding such as index and prognosis and outcome, it is believed that belong to the range of the diseases such as traditional Chinese medicine " fat ", " rouge is turbid ", " phlegm wet " " blood stasis ".

Fat derives from body fluid, is one of base substance of human body, though record of the ancient physician without " hyperlipidemia ", There is the discussion much crossed about fat and contain harm to the human body.Formation for " rouge ", " cream ", " the infirmity body fluid of Ling Shu Miraculous Pivot or Divine Axis five is other " are pointed out " body fluid of five cereals and combined into cream person, it is interior to seep in bone sky, help brains, and flow down in negative stock." Zhang Jingyue is " class is through five It is other in body fluid " this note is said in a piece and " body fluid and is combined into green person, is then marrow for brain to fill up among bone sky, be essence be blood." clear Fat is elaborated from body fluid, is one of base substance of human body, ancient medicine be also recognized that fat generation in blood, defeated cloth, Metabolic disorder can cause a disease, and such as " Plain Questions vitality of human communicating and corresponding to the universe opinion " is said: " change of sorghum, the raw big fourth of foot." " Medicine Comprehended " have more this Point out to body: " ordinary person's addiction delicious food or pure wine milk are dead drunk, it is interior it is wet from interior by humidogene phlegm, phlegm heat, hot air wind producing, the nothing therefore soldier so faints Know." qi-blood-body fluid metabolism disorder is figuratively illustrated, cause phlegm-blood stasis to be cemented among blood vessels, saliva blood stiff can be made, be not easy Circulation, and stop up stagnant trouble caused by human body separating clear and excreting turbid dysfunction, it more coincide with the concept of modern hyperlipidemia.

Traditional Chinese medicine thinks that the generation of dyslipidemia and age, diet, constitution and inherent cause have certain relationship.Wherein external cause It is the product of overfeeding greasy and surfeit flavour, delicious food, property sweet in flavor is slow, and it is slow then temper is stagnant, it cannot change turbid and give birth to phlegm wet, internal cause is internal organs function It can lack of proper care, failure of qi transforming fluid, then the turbid retardance of phlegm, functional activity of QI being not smooth, venation block.Hyperlipidemia clinical manifestation is intricate, but basic The cause of disease is asthenia in origin and asthenia in superficiality.This void and liver and spleen deficiency of the kidney virtual relation are closer, and disease and evil is mostly phlegm, the stasis of blood, and two kinds of mutual shadows of disease and evil It rings, phlegm can cause the stasis of blood, and the stasis of blood can give birth to phlegm, and phlegm-turbidity and blood stasis blood is mutually fought knot in sering, and phlegm-turbidity and blood stasis blood formation pathological product, root is in internal organs function It can imbalance.Therefore blockage of phlegm and blood stasis, visceral dysfunction are the basic pathogenesis that dyslipidemia is formed.

Summary of the invention

In view of the above-mentioned problems, it is an object of that present invention to provide a kind of with the Chinese materia medica preparation of hypolipemic function and its preparation side Method, the Chinese materia medica preparation low raw-material cost is easy to use, practical, with strong points, can effective reducing blood lipid, toxic side effect is small.

In order to achieve the above-mentioned object of the invention, the present invention provides following technical schemes.

A kind of Chinese materia medica preparation with hypolipemic function, is made of the raw material of following parts by weight: 5-15 parts of Radix Notoginseng, hawthorn 5-15 parts, 5-15 parts of rhizoma alismatis, 5-15 parts of cassia seed, 5-15 parts of mulberry leaf, 5-15 parts of banana skin, 5-15 parts of safflower, 5-15 parts of ganoderma lucidum, 5-15 parts of the tuber of multiflower knotweed, 5-15 parts of pueraria lobata, 5-15 parts of Radix Glycyrrhizae.

The Chinese materia medica preparation with hypolipemic function is the oral preparations such as Chinese herbal medicine powder, the water-bindered pill, honeyed bolus.

The preparation method of the Chinese materia medica preparation with hypolipemic function, includes the following steps.

Step 1, pretreatment: banana skin is cut into the segment of 2CM or so after 40-45 DEG C of drying room is dried, and sterilizes standby With other medicinal materials get material with production ordering and check material code name, the name of an article, specification, number and weight, and carry out coat And disinfection.

Step 2, granulation: by formula rate weigh Radix Notoginseng, hawthorn, rhizoma alismatis, cassia seed, mulberry leaf, safflower, part ganoderma lucidum, the tuber of multiflower knotweed, Pueraria lobata, Radix Glycyrrhizae.Raw material is put into mixer-granulator and pelletizes, and Particle size requirements are greater than 60 meshes, less than 16 meshes.

Step 3, drying: after granulation, being dried, and drying time is 8 hours, and drying temperature is controlled at 35-40 DEG C.

Step 4, whole grain: the material after drying is subjected to whole grain processing in pelletizing machine.

Step 5, mixing filling: by the material after step 4 whole grain, the auxiliary materials such as lactose, amylum pregelatinisatum, superfine silica gel powder are added Afterwards, it is uniformly mixed in mixing machine, is then packed on automatic packaging machine.

Step 6 is heat-shrinked: ready-made inner wrapping product being accomplished fluently the corresponding date of manufacture, heat shrink films is packaged and carries out hot receipts Contracting.

Step 7, metal detection: the product after thermal contraction is placed on food metal detector and is detected, is then packed It is packaged, obtains finished product.

Step 8, storage: finished product is put into the product qualification area of storehouse.

Each raw material pharmacological action is as follows.

Radix Notoginseng: sweet in flavor, slight bitter, warm-natured, return heart, liver, stomach, small intestinl channel have hemostasis, activating microcirculation and removing stasis medicinal, strengthening by means of tonics, lipid-loweringing The effect of decompression.Research shows that the water of total lipid can be reduced in blood lipid metabolism by reducing the effect of blood cholesterol and blood-lipoids It is flat, especially it is substantially reduced content of triglyceride, the effect of atherosclerosis.Arasaponin same rouge in alimentary canal Class combines and forms the substance for being not easy to absorb, and prevents lipid from depositing in the blood vessels to protect inner membrance, prevents artery sclerosis, reduces damage Wound.Studies have shown that 5% glucose injection 250mL diabetic 0.9%NaCl solution is added with arasaponin 500mg It slowly instils after 25mL dilution, once a day, the course for the treatment of 2 weeks.Pretherapy and post-treatment blood lipid and blood viscosity value are detected, blood lipid after as a result treating And blood viscosity decreased significantly, and show that arasaponin treatment hyperlipidemia is significant in efficacy with High blood viscosty.

Hawthorn: returns spleen, stomach, Liver Channel, tool food digesting stomach fortifying, change the effect of turbid lipid-loweringing at scattered stasis.Modern study proves that mountain Short, bristly hair or beard extract has effect for reducing fat relatively certainly to the various hyperlipidemia models of different animals, can significantly reduce High cholesterol diet New Zealand White Rabbit and grey mouse serum total cholesterol and serum triglyceride level；Ursolic acid and Hyperoside in hawthorn have bright Aobvious reduction cholesterol, adjusting blood lipid and the raising active drug action of serum superoxide dismutases, these effects are for controlling It treats hyperlipidemia, prevention blood vessel endothelium injury, the formation of blood vessel scleratheroma prevented to have important meaning.

Rhizoma alismatis has water excreting dampness, purge heat resolving sputum the effect of, it is modern research shows that rhizoma alismatis has drop blood for expelling the heat-evil, diuresis Rouge effect；Its extract and monomer component animal experiments show that, rhizoma alismatis has the function of good reduction serum cholesterol, The mechanism of effect may be related to the metabolism of cholesterol with the absorption and liver for influencing body exogenous cholesterol；In rhizoma alismatis Triterpene alcohols chemical component has the apparent effect for reducing rat blood serum lipids contents.

Cassia seed: nature and flavor are sweet, bitter, salty, slightly cold, return liver, kidney, large intestine channel, have effects that clearing liver kidney-nourishing, sharp water defaecation. Research shows that cassia seed has good effect for reducing fat, cassia seed anthraquinones are the main active components of cassia seed lipid-loweringing；It is logical Influence of the observation cassia seed to experimental hypercholesterolemicrabbits Rabbit Model is crossed, as a result, it has been found that the Anthraquinones contained in cassia seed Closing object has catharsis effect, can be reduced enteron aisle to the absorption of cholesterol etc. and increases its excretion；Prompt cassia seed anthraquinone glycoside may It is that blood lipid is reduced by the absorption and increase excretion of the exogenous lipid of reduction；Protein cooperates with lipid-loweringing existing with anthraquinone glucosides As also having prompted cassia seed as a kind of superiority with multiple target point, the drug of multipath lipid-loweringing effect.

Mulberry leaf, nature and flavor bitter sweet are trembled with fear, sweet so beneficial blood, trembles with fear so cool blood.Have effects that nourishing liver and improving eyesight, relax bowel and defecation.With Modern medicines analytical technology and pharmacological research and development, show in mulberry leaf containing flavone compound have good drop blood Rouge effect should have certain effect for diseases such as prevention of arterial atherosis, coronary heart disease.

The effect of banana skin, regulating spleen and stomach, laxative constipation.Containing Multiple components, wherein polyphenol component can be substantially reduced TG, TC, LDL-C are horizontal, increase HDL-C level, have the function of certain reducing blood lipid prevention of arterial atherosis formation；Banana skin Polyphenol has many phenolic hydroxyl group, provides H+ in conjunction with interior free yl by autoxidation, it is made to be reduced to inert compound, with The deposition of cholesterol and its oxide on arterial wall is prevented, to promote the transhipment and removing of cholesterol, improves blood periphery Circulation plays the role of prevention hyperlipidemia, inhibits artery sclerosis formation.

Ganoderma lucidum, brain tonic kidney-nourishing have long applicating history, result of study in China as a kind of famous medicinal fungus It can be substantially reduced hyperlipemia animal serum TC, TG and LDL-C content after showing ganoderma lucidum administration, and can be alleviated under HDL-C Drop trend can effectively improve the blood lipid level of test rat, have effects that reduce blood lipid.

The tuber of multiflower knotweed, nourishing the blood and yin, relax bowel and defecation have apparent effect for reducing blood fat.Experimental study shows the tuber of multiflower knotweed to high in fat dynamic TC, TG, free cholesterol and the cholesterol ester of object model have significant effect for reducing fat；Data show that high lipid food can be significant Ground causes total cholesterol in rabbit plasma to accumulate；Also reduce the Basal activity of rabbit blood red cell membrane Ca2+, Mg2+-ATPase close 20%；And the activity of Ca2+, Mg2+-ATPase of Calmodulin-dependent (CaM) activation are then the 144% of normal rabbit.The tuber of multiflower knotweed it is main 2,3,5,4'- tetrahydroxystilbene -2-O- β-D- glucoside (THSG) of active constituent has good regulating blood lipid action, energy Enough effectively control Hyperlipemia model rat serum TCs and LDL-C are increased, and can significantly reduce atherosclerosis index, and energy Enough increase the expression of ldl receptor.In addition, studying the shadow of Polygonum Multiflorum Thunb. On The Serum Lipid In Rats by experiment feeding rat It ringing, the results showed that TG, TC, LDL-C content and LDL-C/HDL-C ratio in rat blood serum can be effectively reduced in radix-polygoni multiflori extract, And HDL-C content and HDL-C/TC ratio are significantly raised.

Pueraria lobata, rising Yang invigorating the spleen are Pueraria lobota containing a large amount of flavone compound, such as Puerarin, daidzein, daidzin The main functional component of root.Kudzu root extract can be substantially reduced the blood lipid level of food-borne hyperlipidemia rats, reduce TC, TG, LDL-C are horizontal, and it is horizontal to improve HDL-C；ET level significantly reduces；NO level significantly improves, and can reduce lipid peroxidation journey Degree, improves the oxidation resistance of body, is conducive to prevent and treat atherosclerosis, reduces the generation of cardiovascular and cerebrovascular disease.

Safflower is one of traditional Chinese medicine clinical commonly used drug, and sweet in flavor, slight bitter is warm-natured, there is removing heat from the liver, menstruation regulating, work Blood, hemostasis, analgesic, detumescence and safflower can significantly reduce rat blood serum total cholesterol (TC), triacylglycerol the effect of nourish positive essence (TG) and low-density lipoprotein (LDL) content.Can be reduced total TC, TG in test-type atherosclerosis (AS) quail blood plasma, LDL-C is horizontal and inhibits the formation of Aortic Plaque.

Radix Glycyrrhizae, as Chinese medicine important simply, through Chinese medicine compound prescription is added frequently as a kind of auxiliary material.Its is sweet in flavor mild-natured, tool It invigorates the spleen and benefits qi, the effect of coordinating the drug actions of a prescription.Weight gain of three dosage groups of glycyrrhiza total flavonoid to Hyperlipemia model rat There is good inhibiting effect with fat coefficient, can inhibit rat body weight and reduces rat kidney peripheral adipose and testis week The fat enclosed, this result, which discloses glycyrrhiza total flavonoid, can reduce the accumulation of fat.Result of study shows licoflavone tool There is preferable effect for reducing fat, has some improvement to hyperlipidemia.On blood lipids index (TG, TC, LDL, HDL), Radix Glycyrrhizae Three dosage groups of general flavone all have apparent improvement to it.

The compatibility paraphrase of prescription of the present invention: Chinese medicine thinks that the hyperlipemia cause of disease is mostly two kinds of mutual shadows of disease and evil caused by phlegm, the stasis of blood Sound, phlegm can cause the stasis of blood, and the stasis of blood can give birth to phlegm, and phlegm-turbidity and blood stasis blood is mutually fought and tied in arteries and veins blood, this disease root loses in spleen, liver, the dirty function of kidney three It adjusts.This formula is monarch with Radix Notoginseng, hawthorn, rhizoma alismatis, Radix Notoginseng can promoting blood circulation and hemostasis, i.e. activating microcirculation and removing stasis medicinal, and can anti-promoting blood circulation too stop blooding, Also have a strengthening by means of tonics, hawthorn, digestion-promoting spleen-invigorating, scattered stasis, taste are strong, and middle coke QI movement being in harmonious way, then phlegm excreting dampness does not regenerate, blood Rouge must drop.Rhizoma alismatis clearing damp and promoting diuresis, resolving sputum of purging heat, it is turbid to dissolve internal phlegm, and three medicines share activating microcirculation and removing stasis medicinal, eliminating dampness and resolving phlegm, adjusts spleen Stomach makes the turbid elimination of unobstructed vessel, phlegm, middle coke mechanism of qi tonneau；Cassia seed clearing liver kidney-nourishing, sharp water defaecation, mulberry leaf nourishing liver and improving eyesight, ease constipation Defaecation, banana skin regulating spleen and stomach, laxative constipation are ministerial drug, three medicines can defaecation, and can help, and be the agent of laxative, make water Damp phlegm drink goes out with ambassador without hurting healthy tendency, safflower blood circulation, and stasis eliminatings analgesic helps Radix Notoginseng, three short, bristly hair or beard activating microcirculation and removing stasis medicinal, and all ministerial drugs close With principal drug assistance activating microcirculation and removing stasis medicinal, sharp aquation phlegm；Ganoderma lucidum is used for brain tonic kidney-nourishing, tuber of multiflower knotweed nourishing the blood and yin, relax bowel and defecation, and pueraria lobata rising Yang is strong Spleen, ganoderma lucidum, the tuber of multiflower knotweed, pueraria lobata share kidney tonifying, soothing the liver, invigorating the spleen, play regulatory role for spleen, liver, kidney, are altogether adjutant；Radix Glycyrrhizae is to make, Coordinating the drug actions of a prescription.

Compared with prior art, beneficial effects of the present invention.

Western medicine reducing blood lipid is rapid-action with its, curative for effect by doctor and patient's favor, even if being to generally acknowledge that rouge is adjusted most to have Effect and widely applied Statins, also there is a degree of adverse reaction, such as: hepatotoxicity wind agitation, nervous system toxicity and musclar toxicity, And the risk that serious adverse reaction occurs is in dose-dependent relationship.Therefore doctor requires the good dosage of strict control, avoids the occurrence of tight Adverse reaction again.For Western medicine, the advantages of Reducing Blood Lipid by Chinese medicine acts on, is embodied in multipath, multiple target point, wide spectrum and bad React few etc., therefore, Chinese medicine fat reducing health product has a large amount of market demand.For vast hyperlipemic patients, through numerous special Family understands hyperlipemia etiology and pathogenesis for the research of Reducing Blood Lipid by Chinese medicine effect and Chinese medicine, according to many years clinical practice experience It summarizes into we.Hyperlipemia interpretation of the cause, onset and process of an illness phlegm is turbid, blood stasis is related, therefore this formula is monarch with Radix Notoginseng, hawthorn, rhizoma alismatis, resolving sputum Li Shui, Activating microcirculation and removing stasis medicinal, to control its mark, cassia seed mulberry leaf, banana skin, safflower are ministerial drug, and all ministerial drugs share principal drug assistance activating microcirculation and removing stasis medicinal, Li Shui Resolving sputum, though hyperlipemia interpretation of the cause, onset and process of an illness phlegm is turbid, blood stasis is related, basic reason is kidney,liver,spleen functional disturbance, helps with ganoderma lucidum, head Crow, pueraria lobata can help three it is dirty, and kidney, spleen sun gas can be risen, enable that phlegm is turbid, blood stasis is dissolved, Radix Glycyrrhizae is to make, coordinating the drug actions of a prescription.This Formula activating microcirculation and removing stasis medicinal, is tonified the liver and kidney at strengthening the spleen and reducing phlegm, and disease, which is controlled, asks this, and treating both manifestation and root cause of disease makes vital QI recovered after pathogens eliminated, physical recovery.

The present invention is to provide the Chinese medicine preparations with hypolipemic function will be in 16 tastes according to the combination principle of traditional Chinese medicine Medicine carries out prescription, effectively enhances original drug effect of each ingredient, each ingredient is made to complement each other, good synergistic effect is generated, to height Blood lipid disease has significant curative effect.In addition, raw material used in the Chinese medicine preparation derives from the genunie medicinal materials of " Chinese Pharmacopoeia ", poison is secondary to be made With small, there is more apparent effect to sleep is adjusted, there is potential social benefit.

Specific embodiment

Present invention be described in more detail combined with specific embodiments below.

Embodiment 1.

The present embodiment provides a kind of Chinese materia medica preparations for hypolipemic function, are made of the raw material of following parts by weight: 15 parts of Radix Notoginseng, 10 parts of rhizoma alismatis, 10 parts of hawthorn, 10 parts of cassia seed, 10 parts of mulberry leaf, 15 parts of banana skin, 10 parts of safflower, 10 parts of ganoderma lucidum, 10 parts of the tuber of multiflower knotweed, 15 parts of pueraria lobata, 10 parts of Radix Glycyrrhizae.

The preparation method of the Chinese materia medica preparation for hypolipemic function, includes the following steps.

Step 1, pretreatment: banana skin is cut into the segment of 2CM or so after 40-45 DEG C of drying room is dried, and sterilizes standby With other medicinal materials get material with production ordering and check material code name, the name of an article, specification, number and weight etc., and outside being gone Clothing and disinfection.

Step 2, granulation: Radix Notoginseng, hawthorn, rhizoma alismatis, cassia seed, mulberry leaf, safflower, part ganoderma lucidum, the tuber of multiflower knotweed, Pueraria lobota are taken by formula rate Root, Radix Glycyrrhizae.

Raw material is put into mixer-granulator and pelletizes, and Particle size requirements are greater than 60 meshes, less than 16 meshes.

Step 3, drying: after granulation, being dried, and drying time is 8 hours, and drying temperature is controlled at 35-40 DEG C.

Step 4, whole grain: the material after drying is subjected to whole grain processing in pelletizing machine.

Step 5, mixing filling: by the material after step 4 whole grain, the auxiliary materials such as lactose, amylum pregelatinisatum, superfine silica gel powder are added Afterwards, it is uniformly mixed in mixing machine, is then packed on automatic packaging machine.

Step 6 is heat-shrinked: ready-made inner wrapping product being accomplished fluently the corresponding date of manufacture, heat shrink films is packaged and carries out hot receipts Contracting.

Step 7, metal detection: the product after thermal contraction is placed on food metal detector and is detected, is then packed It is packaged, obtains finished product.

Step 8, storage: finished product is put into the product qualification area of storehouse.

Embodiment 2.

The present embodiment provides a kind of Chinese medicine preparations for hypolipemic function, are made of the raw material of following parts by weight: 10 parts of Radix Notoginseng, 15 parts of hawthorn, 15 parts of rhizoma alismatis, 5 parts of cassia seed, 15 parts of mulberry leaf, 15 parts of banana skin, 5 parts of safflower, 5 parts of ganoderma lucidum, the tuber of multiflower knotweed 5 parts, 10 parts of pueraria lobata, 5 parts of Radix Glycyrrhizae.

The preparation method is the same as that of Example 1 for the Chinese materia medica preparation for hypolipemic function.

Embodiment 3.

The present embodiment provides a kind of Chinese medicine preparations for hypolipemic function, are made of the raw material of following parts by weight: 5 parts of Radix Notoginseng, 5 parts of hawthorn, 5 parts of rhizoma alismatis, 15 parts of cassia seed, 15 parts of banana skin, 10 parts of mulberry leaf, 15 parts of safflower, 15 parts of ganoderma lucidum, the tuber of multiflower knotweed 15 parts, 5 parts of pueraria lobata, 15 parts of Radix Glycyrrhizae.

The preparation method is the same as that of Example 1 for the Chinese materia medica preparation for hypolipemic function.

The experiment of 4 pharmacodynamic study of embodiment.

1. experimental animal: male Wistar rat 90, weight (200 ± 20) g, Sd mouse weight (20 ± 2) g, (offer of Liaoning University of TCM's Experimental Animal Center).

2. experimental material: homemade traditional Chinese drug lipid-loweringing is formulated alcohol extract (density 1.3), Simvastatin Tablets specification 20mg*14 piece (Shandong Xin Qi pharmaceutcal corporation, Ltd).

3. experimental method.

Influence of the 3.1 Chinese medicine lipid-loweringing formulas to normal rat blood lipid: Wistar rat 30, it is randomly divided into experimental group 20 Only, control group 10.Experimental group continuously gives Chinese medicine lipid-loweringing formula (12 g/kg) extracting solution, and control group gives same volume Physiological saline, 2 groups equal stomach-filling 5 days, one time a day.Broken end took blood on 6th, solid with enzyme process (GPO PAP method) measurement total gallbladder of serum Alcohol (TC)；Serum triglyceride (TG) is measured with enzymatic end pointassay (GPO PAP method)；It is measured with phosphotungstic acid magnesium precipitate method Serum High Density Lipoprotein Cholesterol (HDL C).

Influence of the 3.2 Chinese medicine lipid-loweringing formulas to hyperlipemia rat blood lipid: Wistar rat 60, be randomly divided into normal group, Model group, Simvastatin group and large, medium and small totally 6 groups of dosage group, every group 10 of Chinese medicine lipid-loweringing formula.Normal group gives normal feeding Material, other 5 groups are given high lipid food (10 % of milk powder, lard 5%, 10 % of egg, cholate 0.5%, 1 % of cod-liver oil, 73.5 % Basal feed).Normal group and the isometric physiological saline of model group stomach-filling；0. 8 mg of Simvastatin group stomach-filling/kg Simvastatin Suspension；Chinese medicine lipid-loweringing is formulated large, medium and small dosage group difference 12,8 and 4 g of stomach-filling/kg Chinese medicine lipid-loweringing and is formulated alcohol extract. One time a day, broken end takes blood system from serum to each group after continuous 15 days, last dose 1 hour, measures TC, TG and HDLC, is used in combination Friedwald formula calculates low density lipoprotein cholesterol (LDLC).

3.3 acute toxicity testings: SD mouse 20, weight (20 ± 2) g.Give mouse stomach-filling Chinese medicine through preliminary experiment Lipid-loweringing is formulated alcohol extract 0. 6 ml/20 g, carries out maximal tolerance dose observation experiment.20 mouse are in points 3 times in 24 hours Stomach-filling Jianpi Jiangzhi Ling suspension, the every time g of 0. 6 ml/20,10 hours observation maximal tolerance doses of conventinal breeding.

4 experimental results.

4. the influence of 1 pair of normal rat blood lipid: Chinese medicine lipid-loweringing formula has reduction effect to normal rat TC, TG, right HDLC has raising effect, with normal group comparing difference without conspicuousness (P > 0.05).Wherein control group TC value reduces by 21.53%, TG value reduces by 3. 81%, and LDLC value drops 37.28%, HDLC value and increases 10.12%, is shown in Table 1.

The influence of 4.2 Chinese medicine lipid-loweringing recipe on experimental hyperlipidemic rats: Chinese medicine lipid-loweringing formula is big, middle dosage can reduce TC, Wherein middle dosage and large dosage group have conspicuousness (P is < 0. 01) with model group comparing difference, and small dose group and model Group comparing difference can reduce TC content up to 8. 41% without conspicuousness, illustrate also have certain TC that reduces to act on.Simvastatin is also Has the function of good reduction TC, it is similar to be formulated large dosage of group to Chinese medicine lipid-loweringing.To TG, Simvastatin and Chinese medicine lipid-loweringing formula Greatly, middle dose group is substantially reduced effect, and compared with model group, difference has conspicuousness (P is < 0. 05)；Small dose group With model group comparing difference without conspicuousness, but the content that can reduce TG illustrates also have certain TG that reduces to act on up to 5. 41%.For HDLC, Simvastatin and Chinese medicine lipid-loweringing are formulated big, middle dose group and are increased significantly effect, compared with model group, have significant Sex differernce (P is < 0. 05)；Small dose group and model group comparing difference are without conspicuousness, but the content that can increase HDC reaches 14.06%, illustrate also play the role of centainly increasing HDLC.For LDLC, Simvastatin and Chinese medicine lipid-loweringing are formulated big, middle dose group There is apparent reduction to act on, compared with model group, Simvastatin and Chinese medicine lipid-loweringing are formulated big, middle dose group difference and have significantly Property (P < 0. 01 or P < 0. 05)；And small dose group and model group comparing difference be without conspicuousness, but can reduce containing for LDLC Amount illustrates also play the role of reducing LDL C up to 11.07%.It is shown in Table 2.

4.3 acute toxicity testings: point 3 stomach-filling Chinese medicine lipid-loweringing formulas, each 0.6ml/20 g are added up in 24 hours 198g/kg, this dosage are equivalent to 405 times of adult human dose, as a result have no animal dead and obvious adverse reaction occur.Show Chinese medicine lipid-loweringing is formulated small toxicity, takes orally safety, can provide clinical use.

5 typical case of embodiment.

1 Mr. Wang of case, female 72 years old, in retired employee's physical examination of in July, 2016 unit organization, detect total cholesterol Value is 6.51, as hyperlipidemia, and with critical hypertension.Class drug is stung from purchase and carries out lipid-loweringing, and after one month, cholesterol is extensive Normal level has been arrived again.After seeing that cholesterol restores normal, Mr. Wang stopped drug administration, be chemically examined after one month, and total gallbladder is solid Alcohol gos up again to previous level.Layman accompanies, Sui Lai our hospital outpatient clinic.Existing symptom: feeling dizzy, be out of strength, early after the meal Improve, easily feel sleepy in the afternoon, night is awake, pink tongue, yellow tongue fur.Recipe: embodiment 1, decoction, two times a day.After three months, head Confused brain is swollen, symptom out of strength mitigates, and night dormancy is good, and total cholesterol value has restored normal range (NR) for 6.21, because there are also dizzy, diseases out of strength Shape intends top and adds and subtracts medication, further consultation after one month, and other symptoms disappear.

2 Lee of case, male, 38 years old, has hyperlipidemia medical history 9 years, and interruption takes simvastatin, fenofibrate, Effects of Xuezhikang Equal drugs, blood lipid can drop always.Take fenofibrate within nearest one month, only night takes once, there is apparent Lumbago Shape worries side effect, the hospitalization of Sui Lai our hospital.Existing symptom: flushing, out of strength, waist abdomen is fat, tongue is red, yellow and greasy fur.Auxiliary inspection Look into: blood bio-chemistry checking shows: GGT145U/L；TP88g/L；ALB44g/L；GLO42g/L ALB/GLO1.03；CHO6.48mmol/ L；TG11.29mmol/L；LDL/HDL0.03；Belly color ultrasound is shown: moderate fatty liver.Treatment: 1. simvastatins are oral, daily mouth Dosing is 80mg, and the early, noon respectively takes 20mg, is taken at bed time with 40mg, 2. embodiments 1, decoction, two times a day.Go out after one month Institute, blood bio-chemistry checking index in the normal range, to consolidate curative effect, continue to use top medication, further consultation after two months, blood lipid keeps good It is good, patient's bland diet is advised, appropriate exercise, in case hyperlipemia recurs.

3 Zhu of case, female, 65 years old.Have combined hyperlipidemia familial medical history 2 years, after making a definite diagnosis, once interruption take Simvastatin, The drugs lipid-loweringing such as Atorvastatin calcium, now not rule medication, blood lipid control are bad；Occurs dizzy, companion's head before patient 5 days after fatigue Distending pain, top-heavy sense, with tinnitus, ignore object rotation with nausea without vomiting, and symptom is without substantially reduced after rest, then to hospital It is medical.Physical examination: 36.5 DEG C of body temperature, 65 beats/min of pulse, 22 beats/min, 160/100 mmHg of blood pressure are breathed, height 155 Cm, 82 kg of weight, constitutional index (BMI) are 36.Auxiliary examination: blood bio-chemistry checking shows: total cholesterol is 6.68 mmol/L；It is sweet Oily three esters (TG) are 3.46 mmol/L；High-density lipoprotein cholesterol (HDL-C) is 1.18 mmol/L；Low-density lipoprotein gallbladder Sterol (LDL-C) is 4.65 mmol/L；Have existing symptom: face is micro- red, and dizzy with distending pain, tinnitus, tongue fur is greasy, wiry and rolling pulse.Because patient is flat When with high salt, high oily diet, it is fat and do not like to move, have combined hyperlipidemia familial medical history, treat: 1. diet programs: regular less salt, Low fat diet reinforces postprandial exercise, 1200 kilocalories of daily standard total amount of heat, staple food 200 ~ 250 g, oily 18g, protein 40g. 2. motion scheme: usually motion mode be take a walk or fitness exercise, run duration > 0.5 hour/day, 5 days/week.3. recipe: hydrochloric acid 10 mg of benazepil/d controls blood pressure;Take Simvastatin (simvastatin) 20 mg/d control blood lipid；Embodiment 3, decoction, one Twice-daily.Leave hospital after two months, all symptoms disappear, and in the normal range, 125/90 mmHg of blood pressure continues blood bio-chemistry checking index Benazepril hydrochloride 10mg/d control blood pressure is taken, less salt, low oily diet is paid attention to, keeps movement.

Claims (6)

1. a kind of Chinese materia medica preparation with hypolipemic function, which is characterized in that be made of the raw material of following parts by weight: Radix Notoginseng 5- 15 parts, 5-15 parts of hawthorn, 5-15 parts of rhizoma alismatis, 5-15 parts of cassia seed, 5-15 parts of mulberry leaf, 5-15 parts of banana skin, 5-15 parts of safflower, spirit 5-15 parts of sesame, 5-15 parts of the tuber of multiflower knotweed, 5-15 parts of pueraria lobata, 5-15 parts of Radix Glycyrrhizae.

2. as described in claim 1 with the Chinese materia medica preparation of hypolipemic function, which is characterized in that by the original of following parts by weight Material composition: 15 parts of Radix Notoginseng, 10 parts of rhizoma alismatis, 10 parts of hawthorn, 10 parts of cassia seed, 10 parts of mulberry leaf, 15 parts of banana skin, 10 parts of safflower, spirit 10 parts of sesame, 10 parts of the tuber of multiflower knotweed, 15 parts of pueraria lobata, 10 parts of Radix Glycyrrhizae.

3. as described in claim 1 with the Chinese materia medica preparation of hypolipemic function, which is characterized in that by the original of following parts by weight Material composition: 10 parts of Radix Notoginseng, 15 parts of hawthorn, 15 parts of rhizoma alismatis, 5 parts of cassia seed, 15 parts of mulberry leaf, 15 parts of banana skin, 5 parts of safflower, ganoderma lucidum 5 Part, 5 parts of the tuber of multiflower knotweed, 10 parts of pueraria lobata, 5 parts of Radix Glycyrrhizae.

4. as described in claim 1 with the Chinese materia medica preparation of hypolipemic function, which is characterized in that by the original of following parts by weight Material composition: 5 parts of Radix Notoginseng, 5 parts of hawthorn, 5 parts of rhizoma alismatis, 15 parts of cassia seed, 15 parts of banana skin, 10 parts of mulberry leaf, 15 parts of safflower, ganoderma lucidum 15 Part, 15 parts of the tuber of multiflower knotweed, 5 parts of pueraria lobata, 15 parts of Radix Glycyrrhizae.

5. the Chinese materia medica preparation with hypolipemic function as described in claim 1-4 is any, which is characterized in that dissipated for Chinese patent drug The oral preparations such as agent, the water-bindered pill, honeyed bolus.

6. a kind of preparation method of the Chinese materia medica preparation with hypolipemic function, which is characterized in that specifically includes the following steps:

Step 1, pretreatment: banana skin is cut into the segment of 2CM or so after 40-45 DEG C of drying room is dried, after disinfection to reserve, Its medicinal material gets material with production ordering and checks material code name, the name of an article, specification, number and weight, and carries out coat and disappear Poison；

Step 2, granulation: Radix Notoginseng, hawthorn, rhizoma alismatis, cassia seed, mulberry leaf, safflower, part ganoderma lucidum, the tuber of multiflower knotweed, Pueraria lobota are weighed by formula rate Root, Radix Glycyrrhizae, raw material are put into mixer-granulator and pelletize, and Particle size requirements are greater than 60 meshes, less than 16 meshes；

Step 3, drying: after granulation, being dried, and drying time is 8 hours, and drying temperature is controlled at 35-40 DEG C；

Step 4, whole grain: the material after drying is subjected to whole grain processing in pelletizing machine；

Step 5, mixing filling: by the material after step 4 whole grain, after adding the auxiliary materials such as lactose, amylum pregelatinisatum, superfine silica gel powder, It is uniformly mixed in mixing machine, is then packed on automatic packaging machine；

Step 6 is heat-shrinked: ready-made inner wrapping product being accomplished fluently the corresponding date of manufacture, heat shrink films is packaged and is heat-shrinked；

Step 7, metal detection: the product after thermal contraction being placed on food metal detector and is detected, and then packaging is packaged, Obtain finished product；

Step 8, storage: finished product is put into the product qualification area of storehouse.