CN1334104A - Hypolipemic pill - Google Patents
Hypolipemic pill Download PDFInfo
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- CN1334104A CN1334104A CN 01102858 CN01102858A CN1334104A CN 1334104 A CN1334104 A CN 1334104A CN 01102858 CN01102858 CN 01102858 CN 01102858 A CN01102858 A CN 01102858A CN 1334104 A CN1334104 A CN 1334104A
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- radix
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- rhizoma
- hypolipemic
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Abstract
A hypolipemic medicine in the form of tablet, powder, pill, particle, capsule or oral liquid for treating hyperlipemia is prepared from 10 Chinese-medicinal materials including haw, leech, alismatis rhizome, red sage root, etc. Its advantages are high curative effect and unique preparing process.
Description
The present invention is a kind of treatment hyperlipemia, prevents the pure Chinese medicinal preparation that cardiovascular and cerebrovascular disease takes place, and plays key effect to prevention of arterial is atherosis with cardiovascular and cerebrovascular disease.
Hyperlipemia is common clinical, frequently-occurring disease, does not still have specific short at present, and it belongs to motherland's medical science " fat " category.The differential diagnosis in tcm theory is thought that the treatment of " heart and brain atherosclerosis " should help digestion and is stagnated, promoting flow of QI and blood, and dissolving stasis and dispelling spots so that reduce the absorption of lipid, quickens the metabolism of lipid, eliminates the calm material on the blood vessel wall, thereby reaches the purpose of prevention sclerosis of blood vessels.
The main pharmacological of " hypolipemic pill " is blood fat reducing, viscosity reduction, has the effect of triglyceride reducing and cholesterol reducing, brings high blood pressure down, and coronary blood flow increasing is controlled platelet aggregation and anticoagulation in addition, so hyperlipemia is had curative effect preferably.
Because " hypolipemic pill " have obvious reduction serum TC and TG effect,, make the TC antiport liver quickly in the tunica intima speckle, and excrete through metabolism generation cholic acid therein HOL-C antiport TC.Clinical observation shows, this medicine not only makes cholesterolemia, triglyceride reduce, and HDL-C is raise, for the control cardiovascular and cerebrovascular disease has been opened up a kind of new drug, and show the unique advantage of many-side, multi-level advantageous effect, real ideal medicament for preventing and treating coronary heart disease and cerebral atherosclerosis.
The clinical discovery metabolism disorder is an atherosclerosis, the important risk factor of coronary heart disease.Serum TC whenever falls 1%, and Incidence of CHD approximately descends 2%, thereby reduces hyperlipemia person's TC, TG level, improves the HDL-C level, and for the generation that reduces cardiovascular and cerebrovascular disease, development has great significance.This medicine is the natural green plant simultaneously, has no side effect, and is safe and reliable, can take for a long time.
Therefore, medicine of the present invention is to be the Chinese patent medicine that feedstock production forms with following pharmaceutical composition.
Fructus Crataegi 100-200 gram, Hirudo 100-200 gram, Rhizoma Alismatis 100-200 gram, Radix Salviae Miltiorrhizae 100-200 gram, Radix Notoginseng 100-200 gram, Radix Et Rhizoma Rhei 50-100 gram, Semen Cassiae 50-100 gram, Radix Polygoni Multiflori 50-100 gram, Rhizoma Chuanxiong 50-100 gram, Radix Glycyrrhizae 50-100 restrain (weight portion).
The preferred weight proportioning of pharmaceutical composition of the present invention is:
Fructus Crataegi 100, Hirudo 100, Rhizoma Alismatis 100, Radix Salviae Miltiorrhizae 100, Radix Notoginseng 100, Radix Et Rhizoma Rhei 50, Semen Cassiae 50, Radix Polygoni Multiflori 50, Rhizoma Chuanxiong 50, Radix Glycyrrhizae 50 (weight portion).
Pharmaceutical composition of the present invention can be prepared into any pharmaceutical preparation that is suitable for using clinically according to conventional formulation technology.For example: tablet, powder, pill, granule, capsule, oral liquid etc.
Pharmaceutical composition of the present invention can directly prepare patent medicine, also can extract respectively each combination of compositions, prepares patent medicine then, and these are all within protection scope of the present invention.
Process for preparing medicine of the present invention is:
1, selected crude drug: selected high-quality Chinese crude drug, remove impurity, and differentiate with run-of-the-mill by pharmacopeia regulation and to check.Defective work medical material such as of poor quality, as to go bad, damage by worms, go mouldy must not use.
2, dried: medical materials such as Fructus Crataegi, Hirudo, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Et Rhizoma Rhei, Semen Cassiae, Radix Polygoni Multiflori, Rhizoma Chuanxiong, Radix Glycyrrhizae are placed the stainless (steel) wire dish respectively, send in the digital display air dry oven, temperature is transferred at 60 ℃ of constant temperature, and baking is to 30 minutes, till crude drug parches.
3, coarse powder: the Chinese medicine grinder mesh screen is configured to 40 orders,, sends into respectively and carry out coarse powder in the pulverizer, get 40 order coarse powder exsiccant crude drug, standby.
4, smart powder: the micro jet mesh screen is configured to 150 orders,, sends in the jet mill, make 150 purpose fine powders the coarse powder that processes, standby.
5, be mixed: put into behind the Chinese medicine mixer mix homogeneously medical material that crushes standby.
6, sterilization treatment: the medicine of mix homogeneously is put into clean charging tray, send in the sterilization cabinet and carried out sterilization treatment 2 hours, it is standby that sterile bag is put in taking-up.
7, capsule formulation: with the fine drug powder of sterilization, in No. 0 capsule of packing into promptly.
One, pharmaceutical composition of the present invention, adopt the random packet medication, observe the cholesterol (TC) of this medicine lipid-lowering effect and hyperlipidemia patient, triglyceride (TG), HDL-C (HDL-C), atherogenic index (A1), superoxide dismutase (SOD), the influence of serum malonaldehyde (MDA).The result treats back TC, TG, A1, MDA descend, and HDL-D raises, and compares P<0.05-0.01 with matched group, conclusion, the effect that Chinese medicine has good adjusting lipid metabolism and removes free radical.
Two, 1, pharmaceutical composition of the present invention, adopt healthy mice to be divided into 3 groups at random, cholesterol matched group (being called for short the C group), hypolipemic treatment group (being called for short the T group), normal control group (being called for short the N group) by body weight.Each organizes the basic feedstuff that equal feed is rich in multivitamin and trace element.C group hello 0.7 cholesterol every every day (cholesterol is mixed and made into 0.5% cholesterol feed with basic feedstuff).T group adds every every day on C group basis feeds hypolipemic pill.The N group is only fed the basic granules feedstuff.Each is organized the total amount of taking food every every day and equates that whenever survey body weight once all around, experiment whole process was 10 weeks.
2, assay method and observation index:
(1), blood fat, per 4 weeks survey once, comprise serum total cholesterol (TC), serum levels of triglyceride (TG) is all used enzyme process, finishes on automatic analyzer.
(2), plasma SOD is measured and is adopted the azanol colorimetry.Whole blood GSH-PX measures and adopts the DTNB colorimetry.
(3), blood plasma thromboxane B2 (TXB2), 6-ketone-prostacyclin (6-Ke-to-PGFl
2), survey once weekly, use radioimmunology.
Three, result: in experimentation, organize white mice body weight no significant difference (P>0.05) fully, toxic reaction is not seen in each internal organs section.
(1), there is not significant difference between blood fat (TC, TG) group before the experiment.After the experiment beginning, the cholesterol matched group, hypolipemic treatment group TC is all than blank group obviously raise (P<0.05), whole experiment hypolipemic treatment group TC all is starkly lower than cholesterol matched group (P<0.05), cholesterol matched group TC is from be significantly higher than normal control group (p<0.05) in the 4th week, hypolipemic pill treatment group TG is close with the normal control group, from the 8th week significantly being lower than cholesterol matched group (P<0.05).Show that hypolipemic pill has good fall TC, TG effect.
LPO between each group before the experiment, GSH-Px does not have significant difference.Experiment beginning back blood plasma LPO raises with the rising of blood fat, and the two is high-positive correlation, and cholesterol control serum TC and MDA all are remarkable positive correlation the 10th weekend at the 8th weekend.Along with the experiment process, the cholesterol matched group, hypolipemic treatment group LPO all obviously raises, but the hypolipemic group is at the 8th weekend, the 10th weekend LPO be starkly lower than cholesterol matched group (P<0.05, P<0.005), cholesterol matched group blood GSH-Px vigor is on a declining curve with the blood fat rising, and active the 8th week of hypolipemic group GSH-Px, the 10th weekend is apparently higher than matched group, also be higher than normal group (P<0.05, P<0.01).Show that hypolipemic has reduction LPO, improve the effect of GSH-Px.
(2), blood plasma TXB
2, no significant difference between each group of 6-Keto-PGFla, the normal control group is blood plasma TXB in experimentation
2, 6-Keto-PGFLa does not have obvious change.Along with the rising of TC, the cholesterol matched group, TXB all appears in hypolipemic treatment group
2, FXB
2, 6-Keto-PGFLa rises, and 6-Keto-PGFLa descends.At the 10th weekend, the TXB of hypolipemic treatment group
2Significantly be lower than cholesterol, matched group (P<0.05), 6-Keto-PGFLa then are significantly higher than cholesterol matched group (P<0.05) at the 6th, 10 weekends, and close with the normal control group, illustrate that hypolipemic pill has good adjustment TXB
2, the 6-Keto-PGFLa balanced action.
This experimental result shows, hypolipemic pill has good fall TC, TG effect, is one of basis of the anti-AS of hypolipemic pill so adjust blood lipid metabolism.
Chinese medicine is thought the pathological product of phlegm and blood stasis of AS, should be familiar with from the deficiency of vital energy, the stagnation of QI, blood stasis, angle that expectorant is turbid, hypolipemic pill is just according to these theories, select for use and have the vital energy benefiting and the kidney invigorating blood circulation promoting and blood stasis dispelling, the all medicines of Fructus Crataegi, Hirudo, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Et Rhizoma Rhei, Semen Cassiae, Radix Polygoni Multiflori, Rhizoma Chuanxiong, Radix Glycyrrhizae of dehumidifying resolve phlegm effect stop the AS formation and development, and reach the purpose of treatment hyperlipemia.
Embodiment:
Prescription: Fructus Crataegi 100, Hirudo 100, Rhizoma Alismatis 100, Radix Salviae Miltiorrhizae 100, Radix Notoginseng 100, Radix Et Rhizoma Rhei 50, Semen Cassiae 50, Radix Polygoni Multiflori 50, Rhizoma Chuanxiong 50, Radix Glycyrrhizae 50 (weight portion).
Technology:
1, with the crude drug check, after taking by weighing, all medicines such as selected high-quality Fructus Crataegi, Hirudo, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Et Rhizoma Rhei, Semen Cassiae, Radix Polygoni Multiflori, Rhizoma Chuanxiong, Radix Glycyrrhizae.
2, with above-mentioned medical material, place the stainless (steel) wire dish respectively, send in the drying machine, temperature is transferred more than 60 ℃, dry 30 minutes till crude drug parches.
3, the Chinese medicine grinder mesh screen is configured to 40 orders, the good crude drug of drying is sent into respectively carried out coarse powder in the pulverizer.
4, the micro jet mesh screen is configured to 150 orders,, sends in the jet mill, make 150 purpose fine powders the coarse powder that processes, standby.
5, the medical material that crushes is put into behind the Chinese medicine mixer mix homogeneously standby.
6, the medicine of mix homogeneously is put into clean charging tray, send in the sterilization cabinet and carried out sterilization treatment 2 hours, it is standby that sterile bag is put in taking-up.
7, the medicine of making is packed in No. 0 capsule promptly.Perhaps making pellets by mixing medical powder with honey also can be made into tablet, granule and oral liquid etc.
Case 1: open * *, man, 41 years old, height 174cm, 86 kilograms of body weight, the worker of Baihe forestry bureau, dizzy 3 months, when irritable tired more very, sensation of oppression over the chest with shortness of breath, honey stomach, constipation, blood pressure 128/90mmHg, stringy and thready pulse, tongue is dark red, only can adhere to part-time employment, part-time job, part-time work, in JIUYUE in 1999 first visit on the 8th.
Laboratory examination: cholesterol 320mg%, B lipoprotein 1578mg%, triglyceride 96mg%.Be diagnosed as hyperlipemia, give " hypolipemic pill ".Intermittently took 3 months, body weight is reduced to 74 kilograms, blood pressure 116/78mmHg, and the arteries and veins tongue is normal.Cholesterol is reduced to 289mg%, and the B lipoprotein is reduced to 460mg%, triglyceride 75mg%.Patient and feel that symptom dizzy and uncomfortable in chest all eliminates can adhere to full-time working, and advising holds on takes medicine 2 months.Symptom such as that patient does not occur again is dizzy, uncomfortable in chest, breathe hard.
Case 2: the king * *, the man, 53 years old, dizziness, insomnia and dreamful sleep, hypomnesis is existing once to remove certain examination in hospital more than a year, and clinical diagnosis is a hyperlipemia, early stage cerebral arteriosclerosis.Result of laboratory test is: cholesterol 235mg%, B lipoprotein 725mg%, triglyceride 120mg%.Through taking hypolipemic pill, check after 1 month, the result is: cholesterol is reduced to 180mg%, and the B lipoprotein is reduced to 363mg%, and triglyceride is reduced to 78mg%.
Claims (3)
- One, a kind of pure Chinese medicinal preparation " hypolipemic pill " for the treatment of hyperlipemia is characterized in that with Fructus Crataegi, Hirudo, Rhizoma Alismatis, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Et Rhizoma Rhei, Semen Cassiae, Radix Polygoni Multiflori, Rhizoma Chuanxiong, Radix Glycyrrhizae, the medicament that is prepared from according to following proportioning:Fructus Crataegi: 100-200 gram;Hirudo: 100-200 gram;Rhizoma Alismatis: 100-200 gram;Radix Salviae Miltiorrhizae: 100-200 gram;Radix Notoginseng: 100-200 gram;Radix Et Rhizoma Rhei: 50-100 gram;Semen Cassiae: 50-100 gram;Radix Polygoni Multiflori: 50-100 gram;Rhizoma Chuanxiong: 50-100 gram;Radix Glycyrrhizae: 50-100 restrains (weight portion).
- Two, Chinese medicine according to claim 1 is characterized in that Fructus Crataegi and Hirudo, Rhizoma Alismatis and Radix Salviae Miltiorrhizae, and Radix Notoginseng and Radix Et Rhizoma Rhei, Semen Cassiae and Radix Polygoni Multiflori, the proportioning of Rhizoma Chuanxiong and Radix Glycyrrhizae is:Fructus Crataegi: 100Hirudo: 100Rhizoma Alismatis: 100Radix Salviae Miltiorrhizae: 100Radix Notoginseng: 100Radix Et Rhizoma Rhei: 50Semen Cassiae: 50Radix Polygoni Multiflori: 50Rhizoma Chuanxiong: 50Radix Glycyrrhizae: 50 (weight portions).
- Three, according to the Chinese medicine of claim 1 or 10, the dosage form that it is characterized in that this medicine is a tablet, powder, pill, capsule, granule, oral liquid any.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB011028580A CN1137706C (en) | 2001-02-10 | 2001-02-10 | Hypolipemic pill |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CNB011028580A CN1137706C (en) | 2001-02-10 | 2001-02-10 | Hypolipemic pill |
Publications (2)
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CN1334104A true CN1334104A (en) | 2002-02-06 |
CN1137706C CN1137706C (en) | 2004-02-11 |
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CNB011028580A Expired - Fee Related CN1137706C (en) | 2001-02-10 | 2001-02-10 | Hypolipemic pill |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102406771A (en) * | 2011-11-29 | 2012-04-11 | 宋爱民 | Chinese medicine preparation for treating hyperlipaemia |
CN103638302A (en) * | 2013-12-03 | 2014-03-19 | 苏甲臣 | Medicine for treating hyperlipemia |
CN104107244A (en) * | 2014-03-05 | 2014-10-22 | 王悦阳 | Lipid regulation and pulse-beat invigoration pill |
CN107213287A (en) * | 2017-06-30 | 2017-09-29 | 禹州市合同泰药业有限公司 | A kind of prepared slices of Chinese crude drugs for reducing blood fat and preparation method thereof |
CN109364163A (en) * | 2018-12-14 | 2019-02-22 | 辽宁美罗君元药业有限公司 | A kind of Chinese materia medica preparation and preparation method thereof with hypolipemic function |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1330346C (en) * | 2005-05-22 | 2007-08-08 | 崔秀芝 | Chinese proprietary medicine for treating hypertension and hyperlipemia and preparation process thereof |
-
2001
- 2001-02-10 CN CNB011028580A patent/CN1137706C/en not_active Expired - Fee Related
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102406771A (en) * | 2011-11-29 | 2012-04-11 | 宋爱民 | Chinese medicine preparation for treating hyperlipaemia |
CN102406771B (en) * | 2011-11-29 | 2014-03-05 | 宋爱民 | Traditional Chinese medicine preparation for treating hyperlipaemia |
CN103638302A (en) * | 2013-12-03 | 2014-03-19 | 苏甲臣 | Medicine for treating hyperlipemia |
CN104107244A (en) * | 2014-03-05 | 2014-10-22 | 王悦阳 | Lipid regulation and pulse-beat invigoration pill |
CN107213287A (en) * | 2017-06-30 | 2017-09-29 | 禹州市合同泰药业有限公司 | A kind of prepared slices of Chinese crude drugs for reducing blood fat and preparation method thereof |
CN109364163A (en) * | 2018-12-14 | 2019-02-22 | 辽宁美罗君元药业有限公司 | A kind of Chinese materia medica preparation and preparation method thereof with hypolipemic function |
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Publication number | Publication date |
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CN1137706C (en) | 2004-02-11 |
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