CN109363726A - The acquisition device of liquid sample with valve - Google Patents
The acquisition device of liquid sample with valve Download PDFInfo
- Publication number
- CN109363726A CN109363726A CN201811262141.5A CN201811262141A CN109363726A CN 109363726 A CN109363726 A CN 109363726A CN 201811262141 A CN201811262141 A CN 201811262141A CN 109363726 A CN109363726 A CN 109363726A
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- China
- Prior art keywords
- storage pipe
- liquid storage
- acquisition device
- valve
- diversion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0067—Tear or lachrymal fluid
Abstract
The acquisition device of the present invention provides a kind of liquid sample with valve, comprising: liquid storage pipe, with seal cavity, the air pressure of seal cavity is negative pressure；Diversion tube, it is connected to the seal cavity of liquid storage pipe, and there is directed fluid inlet, diversion outlet and the valve being arranged between directed fluid inlet and diversion outlet, valve controls the connection and closing of directed fluid inlet and diversion outlet, and the extended line of directed fluid inlet and the extended line of diversion outlet are formed with angle；And penetrating member, it is used to pierce through organizer, and be connected to the diversion outlet of diversion tube.In the present invention, doctor etc. can be easily and safely by penetrating member to organizer (such as anterior chamber of eyes etc.) automatic collection liquid sample, and the liquid sample for being stored in liquid storage pipe directly easily can be carried out subsequent detection.
Description
Technical field
The present invention relates to medical instruments field, in particular to the acquisition device of a kind of liquid sample with valve.
Background technique
In medical research, organize intracorporal liquid sample that there is important clinic and scientific research value.Such as ophthalmology
In common clinical samples, the liquid such as aqueous humor and vitreous humor sample examines the cause of disease of a variety of retinal diseases and uveitis
Disconnected, treatment guidance and glaucoma drop intraocular pressure etc. have extremely important clinical and scientific research value.Therefore, it effectively acquires and saves
Liquid sample is also link important in the therapeutic process such as clinical operation.
For the liquid sample in such as ophthalmology, puncture and aspiration once becomes the main side for obtaining liquid sample
Method, but since this method has higher requirement to the operation skill of doctor and acquisition position, and the operating process of tapping can
Control property is poor, and doctor needs manually to extract liquid sample from organizer out.Currently, common ophthalmology liquid methods of sample collection is deposited
In following problem: (1) the intraocular liquid specimen amount that can be acquired is less, when acquiring aqueous humor such as puncture of anterior chamber, in order to obtain sufficient amount
Sample must repeatedly press eyeball, be easy to cause complication；(2) using syringe as the acquisition device of liquid sample, but
It is that this method needs doctor's both hands while operating, and controllability is poor, easily occurs aspirating too quickly and causing operation simultaneously
Send out disease；(3) sample being not easy that storage stays sample to take at syringe needle position loses much again；(4) sample acquired on operating table
The process of unloading storage to liquid storage pipe is various again afterwards, increases the workload for taking sample doctor；(5) in addition to Vitrectomy can obtain
Take more vitreous humor, the still method without acquisition vitreous humor minimally invasive well.
Summary of the invention
The present invention in view of the above-mentioned prior art situation and complete, its purpose is to provide a kind of easy to operate and safe
The reliably acquisition device of the liquid sample with valve.
For this purpose, the acquisition device of the present invention provides a kind of liquid sample with valve, comprising: liquid storage pipe, with close
Cavity is sealed, the air pressure of the seal cavity is negative pressure；Diversion tube is connected to the seal cavity of the liquid storage pipe, and has
Directed fluid inlet, diversion outlet and the valve being arranged between the directed fluid inlet and the diversion outlet, the valve control
The connection and closing of the directed fluid inlet and the diversion outlet, and the extended line of the directed fluid inlet and the diversion outlet
Extended line be formed with angle；And penetrating member, it is used to pierce through organizer, and the water conservancy diversion with the diversion tube
Entrance connection.
In the present invention, the operators such as doctor, nurse or other professionals can be conveniently by penetrating member pair
Organizer's (such as anterior chamber or vitreum etc. of eyes) will can easily be acquired by negative pressure automatic collection liquid sample
To the liquid sample for being stored in liquid storage pipe directly carry out subsequent detection, especially suitable in ophthalmology to aqueous humor and vitreous humor
Acquisition.
In addition, the liquid storage pipe is removably connect with the diversion tube in acquisition device according to the present invention.
It finishes to the liquid collection of specimens of liquid storage pipe, is separately separated liquid storage pipe with can be convenient as a result, directly carry out subsequent detection
Step.
In addition, the valve can be the machinery valve of push type in acquisition device according to the present invention.As a result,
The operators such as doctor can be facilitated to operate the valve of diversion tube, to easily control the acquisition of liquid sample.
In addition, the liquid sample can be intraocular aqueous humor in acquisition device according to the present invention.In this feelings
Under condition, easily intraocular aqueous humor can be adopted automatically by negative pressure (such as less than intraocular pressure) characteristic in liquid storage pipe
Collection.
In addition, in the penetrating member, restricted puncture position can be set in acquisition device according to the present invention
Position-limit mechanism.Thereby, it is possible to more accurately control the puncture position of penetrating member, the reliability of operation is improved.
In addition, in acquisition device according to the present invention, the extended line of the directed fluid inlet and the diversion outlet
Extended line, which is formed by angle, to be 30~120 degree or 180~300 degree.In this case, doctor etc. can facilitate operation
Penetrating member avoids liquid storage pipe and diversion tube to adverse effect caused by penetrating member operation.
In addition, liquid storage pipe can be transparent tube body in acquisition device according to the present invention.Thereby, it is possible to convenient
The operators such as doctor observe the acquisition situation of the liquid sample of liquid storage pipe in real time.
In addition, in liquid storage pipe, scale can be set in acquisition device according to the present invention.Doctor etc. grasps as a result,
The collection capacity of liquid sample can be learnt in real time by making personnel.
In addition, further including the set for being removably covered in the penetrating member in acquisition device according to the present invention
Lid.Thereby, it is possible to ensure that acquisition device is in sealing state, and penetrating member is avoided to accidentally injure operator.
In addition, penetrating member can be needle tubing in acquisition device according to the present invention.Thereby, it is possible to facilitate doctor
Equal operators pierce through the acquisition that organizer carries out liquid sample.
In addition, skid resistance strip can be set in the outer surface of liquid storage pipe in acquisition device according to the present invention.By
This, can facilitate the operators such as doctor to remove liquid storage pipe.
In accordance with the invention it is possible to provide a kind of acquisition of liquid sample with valve that can be easy to operate and safe and reliable
Device.
Detailed description of the invention
Fig. 1 is to show the signal of the acquisition device of the liquid sample with valve involved in embodiments of the present invention
Figure.
Fig. 2 is to show the three-dimensional knot of the acquisition device of the liquid sample with valve involved in embodiments of the present invention
Composition.
Fig. 3 is to show the decomposition diagram of acquisition device shown in Fig. 2.
Fig. 4 is to show the schematic diagram of the diversion tube of acquisition device shown in Fig. 2.
Fig. 5 is to show the three-dimensional structure diagram of the diversion tube of acquisition device shown in Fig. 2.
Fig. 6 is to show the diagrammatic cross-section of the diversion tube of the hatching line A-A' along Fig. 5.
Fig. 7 is to show the three-dimensional structure diagram of the penetrating member of acquisition device involved in embodiments of the present invention.
Fig. 8 is to show the usage state diagram of the penetrating member of acquisition device involved in embodiments of the present invention.
Fig. 9 is to show the three-dimensional structure diagram of the upper shield of acquisition device involved in embodiments of the present invention.
Figure 10 is to show the schematic diagram of the access of acquisition device involved in embodiments of the present invention.
Figure 11 is to show the schematic diagram of acquisition device involved in another embodiment of the invention.
Specific embodiment
Hereinafter, explaining the preferred embodiment of the present invention in detail with reference to attached drawing.In the following description, for identical
Component assign identical symbol, the repetitive description thereof will be omitted.Scheme in addition, attached drawing is only schematical, the mutual ruler of component
Very little shape of ratio or component etc. can be with actual difference.
It should be noted that term " includes " and " having " and their any deformation in the present invention, such as wrapped
Include or the process, method, system, product or equipment of possessed a series of steps or units are not necessarily limited to be clearly listed that
A little step or units, but may include or with being not clearly listed or for these process, methods, product or equipment
Intrinsic other step or units.
Fig. 1 is to show the schematic diagram of the acquisition device with valve involved in embodiments of the present invention.Fig. 2 is to show
The three-dimensional structure diagram of liquid sample collecting apparatus with valve involved in embodiments of the present invention.Fig. 3 is to show Fig. 2
Shown in acquisition device decomposition diagram.
As shown in Figure 1, the acquisition device of the liquid sample with valve involved in present embodiment is (following sometimes referred to as " to adopt
Acquisition means ") 1 include liquid storage pipe 10, diversion tube 20 and penetrating member 30.Wherein, diversion tube 20 has control liquid storage pipe 10
The valve 23 (being described later on) being connected to penetrating member 30, thus the operators such as doctor, nurse or other professionals can
Conveniently by penetrating member 30 to the liquid sample in organizer (such as anterior chamber of eyes etc.) by negative pressure come automatic collection,
And the collected liquid sample for being stored in liquid storage pipe directly easily can be subjected to subsequent detection.
In the present embodiment, liquid storage pipe 10 can have seal cavity 11, and the air pressure of the seal cavity 11 is negative pressure.This
In, negative pressure is set according to different usages, that is to say, that the seal cavity 11 of liquid storage pipe 10 can be according to being wanted
At with different negative pressure, negative pressure at this time is limited to the gas of seal cavity 11 for liquid preparation of specimen in the different tissues of acquisition
Pressure is less than the intracorporal air pressure of tissue.For example, corresponding negative pressure refers to small for intraocular liquid sample such as aqueous humor etc.
In intraocular pressure.
In some instances, seal cavity 11 can be formed as the subnormal ambient that air pressure is less than regulation air pressure, thus, it is possible to
Realize the automatic collection to liquid sample.In addition, in order to preferably carry out automatic collection, the usual phase of seal cavity 11 using negative pressure
For organizing intracorporal pressure.In some instances, the air pressure of seal cavity 11 can for example be set according to different usages
It is set to 5000Pa, 1000Pa, 500Pa, 100Pa etc..
In addition, the capacity of the seal cavity 11 of liquid storage pipe 10 it is not also specifically limited, can for 1mL to 20mL, 20mL extremely
50mL or 1mL to 100mL.Such as ophthalmology liquid sample, the volume (capacity) of seal cavity 11 can be 0.05mL
To 0.1mL, 0.1mL to 0.20mL or 0.20mL to 0.50mL.
In some instances, different models can be set into acquisition device 1 involved in present embodiment, correspondingly,
Capacity and vacuum magnitude in liquid storage pipe 10 can be different.Thereby, it is possible to improve the applicability of acquisition device 1.
In some instances, liquid storage pipe 10 can be in hollow cylinder.In addition, in other examples, liquid storage pipe
10 can be in hollow cuboid, hollow multiedge cylinder etc..Thus, it is possible to adapt to the liquid collection of specimens of different purposes.
In some instances, the bottom of liquid storage pipe 10 can be flat, and thus, it is possible to be conducive to the placement of liquid storage pipe 10.
In addition, in some instances, the bottom of liquid storage pipe 10 can also be indent, in this case, it is equally beneficial for liquid storage pipe
10 placement.
In some instances, liquid storage pipe 10 can be made of materials such as plastics, glass or metals.Face as a result, actual
In bed application, the operators such as doctor can be for the liquid storage pipe 10 of different liquid sample selection different materials.
In some instances, liquid storage pipe 10 can be transparent tube body.Thereby, it is possible to facilitate the operators such as doctor real-time
Observe the acquisition situation of the liquid sample of liquid storage pipe in ground.In some instances, liquid storage pipe 10 can be transparent glass tube or modeling
Expects pipe.In addition, in some instances, scale can be set in liquid storage pipe 10.For example, being provided in the outer surface of liquid storage pipe 10
Indicate the scale of liquid storage pipe capacity.In this case, the operators such as doctor can learn the acquisition of liquid sample in real time
Amount.
In some instances, the scale on liquid storage pipe 10 can be arranged along the outer surface of liquid storage pipe 10, the reading of scale
Be sequentially increased since the bottom of liquid storage pipe 10, for example, 0 μ L, 5 μ L, 10 μ L ..., 100 μ L, 200 μ L etc..But the disclosure is unlimited
In this, such as the reading of scale can also be since the junction with diversion tube 20 of liquid storage pipe 10 to the bottom of liquid storage pipe 10
Be sequentially increased, for example, 0 μ L, 5 μ L, 10 μ L ..., 100 μ L, 200 μ L etc..
In some instances, the liquid sample collected of acquisition device 1 can be intraocular aqueous humor.In this case,
Automatic collection easily can be carried out to intraocular aqueous humor by negative pressure (being lower than intraocular pressure) characteristic in liquid storage pipe 10.
In the clinical operation of ophthalmology, the general difficulty of the acquisition of liquid sample is larger, such as the collection capacity such as one of aqueous humor
As be no more than 100 μ L, therefore, how to ensure the dosage of liquid sample collected, avoid excessive acquire etc. to be always that ophthalmology faces
The difficulty faced in bed.It in the present embodiment, can effectively gram by using the negative pressure acquisition device 1 controlled with valve
Take above-mentioned difficulties, it is ensured that the dosage of the liquid sample such as aqueous humor required for doctor etc. can safely and reliably collect.
When in some instances, for being used for acquisition device 1 to acquire intraocular aqueous humor, the collection capacity of aqueous humor is less for example only
For 20~100 μ L, at this point, in order to effectively read thus the seal cavity 11 of liquid storage pipe 10, liquid storage pipe 10 can be arranged to long and narrow
Shape, the floor space that the seal cavity 11 of liquid storage pipe 10 is also arranged to inner cavity is small and height is big.
In some instances, in the outer surface of liquid storage pipe 10, anti-slipping mechanism can be set.Thereby, it is possible to facilitate doctor
Equal operators remove liquid storage pipe 10.In other examples, multiple protrusions have been can be set in the outer surface of liquid storage pipe 10, can
Facilitate the operators such as doctor to remove liquid storage pipe 10, liquid storage pipe 10 is avoided to slide from operator's hand.
In some instances, in addition liquid storage pipe 10 can also configure sealing cover (not shown).For example, when liquid storage pipe 10 acquires
After complete liquid sample, it can be unloaded from diversion tube 20, and cover liquid storage pipe 10 using sealing cover, thus, it is possible to guarantee subsequent storage
The liquid sample of liquid pipe 10 is also convenient for the preservation or inspection of the liquid sample of subsequent liquid storage pipe 10 not by outside contamination.
Fig. 4 is to show the schematic diagram of the diversion tube of acquisition device shown in Fig. 2.Fig. 5 is to show shown in Fig. 2 adopt
The three-dimensional structure diagram of the diversion tube of acquisition means.Fig. 6 is to show the section signal of the diversion tube of the line A-A' along Fig. 5
Figure.
In the acquisition device 1 involved in present embodiment, diversion tube 20 connect and is connected to liquid storage pipe 10, that is,
Access is formed between diversion tube 20 and liquid storage pipe 10 (referring to the Fig. 6 being described later on).Specifically, diversion tube 20 can be with
It is connected to the seal cavity 11 of liquid storage pipe 10, since seal cavity 11 is in negative pressure state, liquid sample can be via leading
Flow tube body 20 and the seal cavity 11 for being flowed into liquid storage pipe 10.
In some instances, diversion tube 20 can form Rule with liquid storage pipe 10 and connect.For example, the one of diversion tube 20
End is that female Luer is connect with the formation of liquid storage pipe 10 Rule.In this case, diversion tube 20 can be removably installed in
Liquid storage pipe 10.
In addition, there is diversion tube 20 directed fluid inlet 21, diversion outlet 22 and setting to go out in directed fluid inlet 21 with water conservancy diversion
Valve 23 between mouth 22.
In the present embodiment, directed fluid inlet 21 can connect with penetrating member 30 and (be described later on), and diversion outlet 22 can
Opening and closing is controlled by valve 23 to be connected to liquid storage pipe 10, and between directed fluid inlet 21 and diversion outlet 22.In such case
Under, liquid storage pipe 10 can be controlled conveniently by control valve 23, and (especially penetrating member 30 is pierced into penetrating member 30
The intracorporal liquid sample of tissue) connection and closure.
As described above, in diversion tube 20, valve 23 can control the connection of directed fluid inlet 21 and diversion outlet 22 with
It closes.In addition, the extended line L2 of the extended line L1 of directed fluid inlet 21 and diversion outlet 22 is formed with angle theta (referring to fig. 4).One
In a little examples, it can be that angle theta can be that the extended line of directed fluid inlet 21 and the extended line of diversion outlet 22, which are formed by angle,
30~330 degree.In this case, doctor etc. can facilitate operation penetrating member 30, inhibit liquid storage pipe 10 and diversion tube 20
To penetrating member 30 in operation caused by adverse effect.
In addition, the extended line of directed fluid inlet 21 and the extended line of diversion outlet 22 are formed by folder in other examples
Angle θ can be 30~120 degree or 180~300 degree.In other examples, the extended line and diversion outlet 22 of directed fluid inlet 21
Extended line be formed by angle theta can be for 90 degree or 270 degree (referring to fig. 4), so, it is easier to the operators such as doctor operate
Acquisition device 1.
In some instances, liquid storage pipe 10 is removably connect with diversion tube 20.As a result, to the liquid mark of liquid storage pipe 10
This acquisition finishes, and is separately separated liquid storage pipe 10 with can be convenient, directly carries out subsequent detecting step.For example, can will store up
Liquid pipe 10 is disassembled from diversion tube 20, and the liquid storage pipe 10 with liquid sample is directly carried out subsequent medicine inspection
It surveys, thus, it is possible to save detection time, improves the efficiency of clinical treatment.In some instances, valve 23 can be push type
Machinery valve.In this case, the operators such as doctor can be facilitated to operate the valve 23 of diversion tube, thus side
Just the acquisition of liquid sample is controlled.Specifically, the operators such as doctor can be by easily being controlled by pressure valve 23
Thus the automatic collection of liquid sample improves the clinical operation efficiency of doctor etc..
As shown in Figure 5 and Figure 6, in the present embodiment, valve 23 substantially may include press head 231 and press head 231
The body of rod 232 of connection, the inner cavity cooperated with the body of rod 232, the sealing ring 233 for being separately positioned on 232 different location of the body of rod and sealing
Circle 234 and the setting elastomeric element 235 in inner cavity 236.
In some instances, press head 231 can be round pie, thus, it is possible to facilitate the operators such as doctor to touch, side
Just it carries out the operation such as pressing.In addition, as shown in Fig. 2, show press head 231 in the situation of the side of valve 23, but the disclosure
Without being limited thereto, in some instances, the other side of valve 23 also can be set in press head 231.
In valve 23, elastomeric element 235 is changed by pressing press head 231, is existed at least be provided with the body of rod 232
First position and the second position in inner cavity 236.Such as when the body of rod 232 squeezes spring 235 and is in first position, water conservancy diversion enters
One end 21a of mouth 21 and one end 22a of diversion outlet 22 are between sealing ring 233 and sealing ring 234, in this case,
Directed fluid inlet 21 is connected with diversion outlet 22 via space 236, and liquid storage pipe 10 is via directed fluid inlet 21, diversion outlet 22 and thorn
Component 30 is worn to be connected to extraneous (organizer)；Such as when the body of rod 232 squeezes spring 235 and is in the second position, such as water conservancy diversion
One end 21a of entrance 21 is between sealing ring 233 and sealing ring 234, in this case, directed fluid inlet 21 and diversion outlet
22 are not connected to, and liquid storage pipe 10 is isolated from the outside.It in this way, can be by press head 231 come the unlatching of control valve 23
And closing, thus easily control have subnormal ambient liquid storage pipe 10 with the external world connection and be isolated.
In the present embodiment, the constituent material of valve 23 is not particularly limited, and in some instances, valve 23 can be
It is made of materials such as plastics, glass or metals.From the point of view of durable, valve 23 preferably uses metal material.
In addition, being also provided with the airtight stopper 24 for liquid storage pipe 10 to be embodied as to negative pressure in diversion tube 20.Tool
For body, in the case where diversion tube 20 (the specifically diversion outlet 22 of diversion tube 20) is connected to liquid storage pipe 10, pass through
Such as needle tubing penetrates the access of airtight stopper 24 to diversion outlet 22, and valve 23 is being kept to be in close state (directed fluid inlet at this time
21 are not connected to diversion outlet 22) in the case where carry out vacuumize process, thereby, it is possible to easily make the seal chamber of liquid storage pipe 10
Body 11 forms the environment of defined subnormal ambient such as less than intraocular pressure.
In addition, airtight stopper 24 can also maintain 10 negative pressure of liquid storage pipe.Specifically, due to extracting vacuum via airtight stopper 24
Afterwards, since airtight stopper 24 still is able to restore original state, the clogging access, therefore, airtight stopper 24 still are able to maintain liquid storage pipe
10 subnormal ambient.In some instances, airtight stopper 24 can be rubber stopper.
In addition, as described above, liquid storage pipe 10 is connect with diversion tube 20, and airtight stopper 24 is formed in leading for diversion tube 20
One end of outflux 22, in order to ensure airtight stopper 24 can be utilized to implement the Negative pressure entrance of liquid storage pipe 10, in liquid storage pipe
10 need at least to expose a part of airtight stopper 24 with diversion tube 20 when connecting, can for example to extract the needle tubing of vacuum
Penetrate airtight stopper 24.
In some instances, sealing ring 233 and sealing ring 234 can be made of medical grade rubber such as silica gel.At other
In example, sealing ring 233 and sealing ring 234 can also be by other medical material structures such as plastics, glass resin, synthetic compounds
At.Thereby, it is possible to guarantee the air-tightness of valve 23 while ensuring to meet requirement of the medical instrument for material.
In addition, in some instances, valve 23 or electrically operated valve.For example, the valve can detect air pressure simultaneously
Or hydraulic variation, after electrically operated valve unlatching detect air pressure or it is hydraulic lower than some value when, electrically operated valve is automatically closed, and makes
Directed fluid inlet 21 is not connected to diversion outlet 22.It in this case, being capable of more convenient operator's operation valve 23.
Fig. 7 is to show the three-dimensional structure diagram of the penetrating member of acquisition device involved in embodiments of the present invention.Fig. 8
It is to show the usage state diagram of the penetrating member of acquisition device involved in embodiments of the present invention.Fig. 9 is to show this
The three-dimensional structure diagram of the upper shield of acquisition device involved in the embodiment of invention.Figure 10 is to show embodiments of the present invention
The schematic diagram of the access of related acquisition device.In fig. 8, example is applied for convenience, shows acquisition device 1 for adopting
Collect the example of the aqueous humor in eyeball 2, however, the present invention is not limited thereto.
As shown in fig. 7, penetrating member 30 may include main body 31 and the puncture portion 32 connecting with main body 31.In addition, main body
31 can be connected to puncture portion 32, and thus liquid sample can flow through penetrating member 30 and reach diversion tube 20.
In some instances, in penetrating member 30, be formed between main body 31 and puncture portion 32 narrow access (referring to
Figure 10), thus, it is possible to ensure liquid sample to make because residing in main body 31 or puncture portion 32 flowing through penetrating member 30
It is lost at liquid sample.This structure is especially suitable for being directed to the situation measuring few liquid sample such as aqueous humor and being extracted.
In some instances, penetrating member 30 can form Rule with diversion tube 20 and connect.Such as diversion tube 20
Female Luer is formed close to one end of directed fluid inlet 21 and is formed Rule with penetrating member 30 and is connect.
In addition, in some instances, penetrating member 30 can be formed as one molding with diversion tube 20.In such case
Under, penetrating member 30 can be from the part that diversion tube 20 is drawn.
In some instances, in penetrating member 30, the restricted position-limit mechanism 33 for piercing through position can be set.It is specific and
The restricted position-limit mechanism 33 for piercing through position is arranged in speech between the main body 31 and puncture portion 32 of penetrating member 30.In this feelings
Under condition, when doctor etc., which will puncture through component 30, is pierced into organizer, puncture (piercing) position of penetrating member 30 is limited, it is possible thereby to
Convenient for the equal depth for controlling penetrating member 30 when acquiring aqueous humor and entering of doctor, penetrating member can be more accurately controlled
30 puncture position effectively avoids enter into too deep and patient is caused to receive secondary injury, improves the reliability of operation.
Here, it pierces through position and refers to that penetrating member 30 is pierced into the position of organizer, specifically, containing liquid by being pierced into
Then the organizer of sample passes through liquid storage pipe so that intracorporal liquid sample is organized to be connected to the seal cavity 11 of liquid storage pipe 10
10 negative pressure and to organizing intracorporal liquid sample to carry out automatic collection.
Penetrating member 30 shown in Fig. 8 is pierced into the example for obtaining aqueous humor sample in eyeball 2, and rainbow should be avoided by piercing through position
The position of film and cornea causes to damage to avoid to above-mentioned tissue.In addition, it is necessary to explanation, penetrating member shown in Fig. 8
Before 30 operation direction is only example effect, such as penetrating member 30 can also be with iris substantially in parallel direction piercing eyeball
Room is to obtain aqueous humor sample.
In some instances, position-limit mechanism 33 can be designed to fit in the surface of organizer, and thus, it is possible to play to pierce
The puncture portion 32 for wearing component 30 is self aligned to pierce through position.Thus, it is possible to facilitate the operators such as doctor to carry out puncture operation.
In some instances, penetrating member 30 can have protrusion 34.By protrusion 34, will puncture through with can be convenient
Component 30 disassembles or will puncture through component 30 from diversion tube 20 and is installed on diversion tube 20.Phase has can be set in protrusion 34
Pair two, more convenient can will puncture through component 30 in this way and disassemble or will puncture through component 30 from diversion tube 20 and be installed on
Diversion tube 20.
In some instances, penetrating member 30 can alongst can also be in by contracting shape.Thus, it is possible to facilitate doctor
The operators such as raw carry out the puncture to organizer, improve reliability and stability.
In addition, in some instances, penetrating member 30 can be needle tubing.In this case, since the front end of needle tubing is
It is tip-shape, therefore can be easy to pierce through organizer's such as eyeball etc..Thereby, it is possible to facilitate the operators such as doctor to pierce through organizer
Carry out the acquisition of liquid sample.
In some instances, the syringe needle outer diameter as the needle tubing of penetrating member 30, can be 0.31-4.57mm, in syringe needle
Diameter can be 0.15-3.81mm.Acquisition for the liquid sample such as ophthalmology, the syringe needle outer diameter of needle tubing be preferably 0.31mm extremely
0.64mm, internal diameter are preferably 0.15mm to 0.33mm, can either effectively acquire liquid sample as a result, can also realize wound most
Smallization accomplishes that safety is minimally invasive and makes a collection of specimens.
As described above, liquid storage pipe 1, diversion tube 2 and penetrating member 3 connect and are formed with narrow access (such as Figure 10 institute
Show), thus liquid sample can be via penetrating member 3, diversion tube 2 and by automatic collection to liquid storage pipe 1.In such case
Under, liquid sample as much as possible can either be effectively collected, can also realize that wound minimizes, accomplishes the minimally invasive collection mark of safety
This.
In addition, in the present embodiment, the length in the puncture portion 32 of penetrating member 30 is not particularly limited, such as eye
For the liquid sample such as aqueous humor of section, the anterior chamber of eyes and the deep enough anterior chamber of energy can be pierced into.
In the present embodiment, acquisition device 1 can also have upper shield 40 (referring to Fig. 3).In some instances, upper shield 40
It is removably installed in penetrating member 30.As shown in Figure 3 and Figure 9, by by liquid storage pipe 10, diversion tube 20, penetrating member 30
It is fitted together with upper shield 40, so as to ensure that acquisition device 1 is in protected state, penetrating member 40 is avoided to accidentally injure doctor
Equal operators.In addition, upper shield 40 can prevent penetrating member 30 from being polluted by dust etc. with blocks dust.
In some instances, upper shield 40 can be the airtight cover for being covered in penetrating member 30.Thus, it is possible to further ensure that
The negative pressure state of liquid storage pipe 10.
In addition, in some instances, upper shield 40 can also cover penetrating member 30 and valve 23 simultaneously.In such case
Under, valve 23 can also obtain the protection of upper shield 40, and valve 23 is avoided to be misused.Here, the tail end of upper shield 40 can be according to valve
The structure of door 23 makees the adjustment of adaptability, so as to matchingly cover valve 23.
In some instances, upper shield 40 can be made of materials such as plastics, glass, metals.In some instances, upper shield 40
It can be in various shapes such as cylindrical body, cuboid, multiedge cylinder or anomalistic objects.
In some instances, it is also provided with skid resistance strip in the outer wall of upper shield 40 (referring to Fig. 9).In some examples
In, skid resistance strip 41 can be set a plurality of, such as the peripheral direction of upper shield 40 be provided with four, eight or 12
Deng.In some instances, skid resistance strip 41 can be arranged along the length direction of upper shield 40, be formed as strip.
In addition, being also provided with protrusion in the outer wall of upper shield 40 in other examples.In other examples, set
The outer wall of lid 40 is also provided with Anti-slip cover.Thereby, it is possible to prevent from skidding in use.
Although being illustrated in conjunction with the accompanying drawings and embodiments to the present invention above, it will be appreciated that above description
The invention is not limited in any way.Those skilled in the art without departing from the true spirit and scope of the present invention may be used
To deform and change to the present invention as needed, these deformations and variation are within the scope of the present invention.
For example, the extended line of directed fluid inlet 21 and the extended line of diversion outlet 22 are formed by angle in acquisition device 1
θ is 180 degree, that is, diversion tube 20 is formed as strip.At the same time, (the specifically thorn of penetrating member 30 of penetrating member 30
Wear portion 32) shape of bending can be set into, as shown in figure 11.In this case, the puncture portion 32 of penetrating member 30 can be with
With bending part 321.Doctor etc. can promote diversion tube 20 from different perspectives as a result, and this structure is especially suitable for intraocular
The acquisition of liquid sample such as aqueous humor.
In some instances, the bending angle of bending part 321 can be such as 30 degree, 45 degree, 60 degree, 90 degree.One
In a little examples, bending part 321 can be made of memory metal material.Thus, it is possible to adjust the angle of bending, according to circumstances with suitable
Answer the acquisition of different parts.
Claims (10)
1. a kind of acquisition device of the liquid sample with valve, which is characterized in that
Include:
Liquid storage pipe, with seal cavity, the air pressure of the seal cavity is negative pressure；
Diversion tube is connected to the seal cavity of the liquid storage pipe, and there is directed fluid inlet, diversion outlet and setting to exist
Valve between the directed fluid inlet and the diversion outlet, the valve control the directed fluid inlet and the diversion outlet
Connection and closing, and the extended line of the extended line of the directed fluid inlet and the diversion outlet is formed with angle；And
Penetrating member is used to pierce through organizer, and is connected to the directed fluid inlet of the diversion tube.
2. acquisition device as described in claim 1, which is characterized in that
The liquid storage pipe is removably connect with the diversion tube.
3. acquisition device as described in claim 1, which is characterized in that
The valve is the machinery valve of push type.
4. acquisition device as described in claim 1, which is characterized in that
The liquid sample is intraocular aqueous humor.
5. acquisition device as claimed in claim 4, which is characterized in that
In the penetrating member, the restricted position-limit mechanism for piercing through position is set.
6. acquisition device as described in claim 1, which is characterized in that
The extended line of the extended line of the directed fluid inlet and the diversion outlet be formed by angle be 30~120 degree or 180~
330 degree.
7. acquisition device as described in claim 1, which is characterized in that
The liquid storage pipe is transparent tube body.
8. acquisition device as claimed in claim 7, which is characterized in that
In the liquid storage pipe, it is provided with scale.
9. acquisition device as described in claim 1, which is characterized in that
It further include the upper shield for being removably covered in the penetrating member.
10. acquisition device as described in claim 1, which is characterized in that
The penetrating member is needle tubing.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110264735.5A CN113143332B (en) | 2018-04-11 | 2018-10-27 | Push type liquid specimen collecting device |
| CN202110267797.1A CN113143333B (en) | 2018-04-11 | 2018-10-27 | Collection device for intraocular liquid specimen |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018103230465 | 2018-04-11 | ||
| CN201810323046.5A CN108433748A (en) | 2018-04-11 | 2018-04-11 | The harvester of liquid sample with valve |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110267797.1A Division CN113143333B (en) | 2018-04-11 | 2018-10-27 | Collection device for intraocular liquid specimen |
| CN202110264735.5A Division CN113143332B (en) | 2018-04-11 | 2018-10-27 | Push type liquid specimen collecting device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109363726A true CN109363726A (en) | 2019-02-22 |
| CN109363726B CN109363726B (en) | 2021-03-30 |
Family
ID=63199683
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810323046.5A Pending CN108433748A (en) | 2018-04-11 | 2018-04-11 | The harvester of liquid sample with valve |
| CN202110267797.1A Active CN113143333B (en) | 2018-04-11 | 2018-10-27 | Collection device for intraocular liquid specimen |
| CN201811262141.5A Active CN109363726B (en) | 2018-04-11 | 2018-10-27 | Liquid specimen collecting device with valve |
| CN202110264735.5A Active CN113143332B (en) | 2018-04-11 | 2018-10-27 | Push type liquid specimen collecting device |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810323046.5A Pending CN108433748A (en) | 2018-04-11 | 2018-04-11 | The harvester of liquid sample with valve |
| CN202110267797.1A Active CN113143333B (en) | 2018-04-11 | 2018-10-27 | Collection device for intraocular liquid specimen |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110264735.5A Active CN113143332B (en) | 2018-04-11 | 2018-10-27 | Push type liquid specimen collecting device |
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| Country | Link |
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| CN (4) | CN108433748A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3777909A4 (en) * | 2018-04-11 | 2021-12-15 | Zhongshan Opththalmic Center of Sun Yat-sen University | Liquid sample collection apparatus with valve |
| CN108652680A (en) * | 2018-04-11 | 2018-10-16 | 吴飞 | A kind of sampling detecting device for eyeball |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN113143333A (en) | 2021-07-23 |
| CN113143332B (en) | 2022-08-05 |
| CN108433748A (en) | 2018-08-24 |
| CN109363726B (en) | 2021-03-30 |
| CN113143332A (en) | 2021-07-23 |
| CN113143333B (en) | 2022-08-05 |
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