CN108433748A - The harvester of liquid sample with valve - Google Patents
The harvester of liquid sample with valve Download PDFInfo
- Publication number
- CN108433748A CN108433748A CN201810323046.5A CN201810323046A CN108433748A CN 108433748 A CN108433748 A CN 108433748A CN 201810323046 A CN201810323046 A CN 201810323046A CN 108433748 A CN108433748 A CN 108433748A
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- CN
- China
- Prior art keywords
- storage pipe
- liquid storage
- harvester
- valve
- diversion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B2010/0067—Tear or lachrymal fluid
Abstract
The harvester of the present invention provides a kind of liquid sample with valve, including：Liquid storage pipe, with seal cavity, the air pressure of seal cavity is negative pressure；Diversion tube, it is connected to the seal cavity of liquid storage pipe, and there is directed fluid inlet, diversion outlet and the valve being arranged between directed fluid inlet and diversion outlet, valve controls the connection and closing of directed fluid inlet and diversion outlet, and the extended line of directed fluid inlet and the extended line of diversion outlet are formed with angle；And penetrating member, it is used to pierce through organizer, and be connected to the diversion outlet of diversion tube.In the present invention, doctor etc. can be easily and safely by penetrating member to organizer (such as anterior chamber etc. of eyes) automatic collection liquid sample, and can the liquid sample for being stored in liquid storage pipe directly easily be carried out subsequent detection.
Description
Technical field
The present invention relates to medical instruments field, more particularly to the harvester of a kind of liquid sample with valve.
Background technology
In medical research, the liquid sample in organizer has important clinic and scientific research value.Such as ophthalmology
In common clinical samples, the liquid such as aqueous humor and vitreous humor sample examines the cause of disease of a variety of retinal diseases and uveitis
Disconnected, treatment guidance and glaucoma drop intraocular pressure etc. have extremely important clinical and scientific research value.Therefore, it effectively acquires and preserves
Liquid sample is also link important in the therapeutic process such as clinical operation.
For the liquid sample in such as ophthalmology, puncture and aspiration once becomes the main side for obtaining liquid sample
Method, but since this method has higher requirement to the operation skill of doctor and acquisition position, and the operating process of tapping can
Control property is poor, and doctor needs manually to extract liquid sample from organizer out.Currently, common ophthalmology liquid methods of sample collection is deposited
In following problem：(1) the intraocular liquid specimen amount that can be acquired is less, when acquiring aqueous humor such as puncture of anterior chamber, in order to obtain sufficient amount
Sample must repeatedly press eyeball, be easy to cause complication；(2) using syringe as the harvester of liquid sample, but
It is that this method needs doctor's both hands to be carried out at the same time operation, and controllability is poor, easily occurs aspirating too quickly and causing operation simultaneously
Send out disease；(3) sample being not easy that storage stays sample to take at syringe needle position loses much again；(4) sample acquired on operating table
The process of unloading storage to liquid storage pipe is various again afterwards, increases the workload for taking sample doctor；(5) in addition to Vitrectomy can obtain
Take more vitreous humor, the still method without acquisition vitreous humor minimally invasive well.
Invention content
The present invention completes in view of the situation of the above-mentioned prior art, and its purpose is to provide a kind of easy to operate and safe
The reliably harvester of the liquid sample with valve.
For this purpose, the harvester of the present invention provides a kind of liquid sample with valve, including：Liquid storage pipe, with close
Cavity is sealed, the air pressure of the seal cavity is negative pressure；Diversion tube is connected to the seal cavity of the liquid storage pipe, and has
Directed fluid inlet, diversion outlet and the valve being arranged between the directed fluid inlet and the diversion outlet, the valve control
The connection and closing of the directed fluid inlet and the diversion outlet, and the extended line of the directed fluid inlet and the diversion outlet
Extended line be formed with angle；And penetrating member, be used to pierce through organizer, and with the water conservancy diversion of the diversion tube
Entrance is connected to.
In the present invention, the operating personnel such as doctor, nurse or other professionals can be conveniently by penetrating member pair
Organizer (such as anterior chamber of eyes or vitreum etc.) will can easily be acquired by negative pressure automatic collection liquid sample
To the liquid sample for being stored in liquid storage pipe directly carry out subsequent detection, especially suitable in ophthalmology to aqueous humor and vitreous humor
Acquisition.
In addition, in harvester according to the present invention, the liquid storage pipe is removably connect with the diversion tube.
It waits for that the liquid collection of specimens of liquid storage pipe finishes as a result, easily liquid storage pipe can be separately separated, directly carry out subsequent detection
Step.
In addition, in harvester according to the present invention, the valve can be the machinery valve of push type.As a result,
The operating personnel such as doctor can be facilitated to operate the valve of diversion tube, to easily control the acquisition of liquid sample.
In addition, in harvester according to the present invention, the liquid sample can be the aqueous humor of intraocular.In this feelings
Under condition, easily the aqueous humor of intraocular can be adopted automatically by negative pressure (such as less than intraocular pressure) characteristic in liquid storage pipe
Collection.
In addition, in harvester according to the present invention, in the penetrating member, restricted puncture position can be set
Position-limit mechanism.Thereby, it is possible to more accurately control the puncture position of penetrating member, the reliability of operation is improved.
In addition, in harvester according to the present invention, the extended line of the directed fluid inlet and the diversion outlet
It can be 30~120 degree or 180~300 degree that extended line, which is formed by angle,.In this case, doctor etc. can be conveniently operated
Penetrating member, harmful effect caused by avoiding liquid storage pipe and diversion tube from operating penetrating member.
In addition, in harvester according to the present invention, liquid storage pipe can be transparent tube body.Thereby, it is possible to convenient
The operating personnel such as doctor observe the acquisition situation of the liquid sample of liquid storage pipe in real time.
In addition, in harvester according to the present invention, in liquid storage pipe, scale can be provided with.The behaviour such as doctor as a result,
The collection capacity of liquid sample can be learnt in real time by making personnel.
Further include the set for being removably covered in the penetrating member in addition, in harvester according to the present invention
Lid.Thereby, it is possible to ensure that harvester is in sealing state, and penetrating member is avoided to accidentally injure operating personnel.
In addition, in harvester according to the present invention, penetrating member can be needle tubing.Thereby, it is possible to facilitate doctor
Equal operating personnel pierce through the acquisition that organizer carries out liquid sample.
In addition, in harvester according to the present invention, skid resistance strip can be provided in the outer surface of liquid storage pipe.By
This, can facilitate the operating personnel such as doctor to remove liquid storage pipe.
In accordance with the invention it is possible to provide a kind of acquisition of the liquid sample with valve that can be easy to operate and safe and reliable
Device.
Description of the drawings
Fig. 1 is the signal for the harvester for showing the liquid sample with valve involved by embodiments of the present invention
Figure.
Fig. 2 is the three-dimensional knot for the harvester for showing the liquid sample with valve involved by embodiments of the present invention
Composition.
Fig. 3 is the decomposition diagram for showing harvester shown in Fig. 2.
Fig. 4 is the schematic diagram for the diversion tube for showing harvester shown in Fig. 2.
Fig. 5 is the three-dimensional structure diagram for the diversion tube for showing harvester shown in Fig. 2.
Fig. 6 is the diagrammatic cross-section for the diversion tube for showing the hatching line A-A' along Fig. 5.
Fig. 7 is the three-dimensional structure diagram for the penetrating member for showing the harvester involved by embodiments of the present invention.
Fig. 8 is the usage state diagram for the penetrating member for showing the harvester involved by embodiments of the present invention.
Fig. 9 is the three-dimensional structure diagram for the upper shield for showing the harvester involved by embodiments of the present invention.
Figure 10 is the schematic diagram for the access for showing the harvester involved by embodiments of the present invention.
Figure 11 is the schematic diagram for showing the harvester involved by another embodiment of the invention.
Specific implementation mode
Hereinafter, refer to the attached drawing, explains the preferred embodiment of the present invention in detail.In the following description, for identical
Component assign identical symbol, the repetitive description thereof will be omitted.Scheme in addition, attached drawing is only schematical, the mutual ruler of component
Very little shape of ratio or component etc. can be with actual difference.
It should be noted that the term " comprising " and " having " in the present invention and their any deformation, such as wrapped
Include or possessed series of steps or the process of unit, method, system, product or equipment are not necessarily limited to clearly to list that
A little steps or unit, but may include or with not listing clearly or for these processes, method, product or equipment
Intrinsic other steps or unit.
Fig. 1 is the schematic diagram for showing the harvester with valve involved by embodiments of the present invention.Fig. 2 is to show
The three-dimensional structure diagram of liquid sample collecting apparatus with valve involved by embodiments of the present invention.Fig. 3 is to show Fig. 2
Shown in harvester decomposition diagram.
As shown in Figure 1, the harvester of the liquid sample with valve involved by present embodiment is (following sometimes referred to as " to adopt
Acquisition means ") 1 include liquid storage pipe 10, diversion tube 20 and penetrating member 30.Wherein, diversion tube 20 has control liquid storage pipe 10
The valve 23 (being described later on) being connected to penetrating member 30, thus the operating personnel such as doctor, nurse or other professionals can
Conveniently by penetrating member 30 to the liquid sample in organizer (such as anterior chamber etc. of eyes) by negative pressure come automatic collection,
And can the collected liquid sample for being stored in liquid storage pipe be directly easily subjected to subsequent detection.
In the present embodiment, liquid storage pipe 10 can have seal cavity 11, and the air pressure of the seal cavity 11 is negative pressure.This
In, negative pressure is set according to different usages, that is to say, that the seal cavity 11 of liquid storage pipe 10 can be according to being wanted
At with different negative pressure, negative pressure at this time is limited to the gas of seal cavity 11 for liquid preparation of specimen in the different tissues of acquisition
Pressure is less than the air pressure in organizer.For example, for the liquid sample of intraocular is such as aqueous humor, corresponding negative pressure refers to small
In intraocular pressure.
In some instances, seal cavity 11 can be formed as the subnormal ambient that air pressure is less than regulation air pressure, thus, it is possible to
Realize the automatic collection to liquid sample.In addition, in order to preferably carry out automatic collection, 11 usual phase of seal cavity using negative pressure
For the pressure in organizer.In some instances, the air pressure of seal cavity 11 can for example be set according to different usages
It is set to 5000Pa, 1000Pa, 500Pa, 100Pa etc..
In addition, the capacity of the seal cavity 11 of liquid storage pipe 10 it is not also specifically limited, can be 1mL to 20mL, 20mL extremely
50mL or 1mL to 100mL.Such as ophthalmology liquid sample, the volume (capacity) of seal cavity 11 can be 0.05mL
To 0.1mL, 0.1mL to 0.20mL or 0.20mL to 0.50mL.
In some instances, the harvester 1 involved by present embodiment can be arranged to different models, correspondingly,
Capacity and vacuum magnitude in liquid storage pipe 10 can be different.Thereby, it is possible to improve the applicability of harvester 1.
In some instances, liquid storage pipe 10 can be in hollow cylinder.In addition, in other examples, liquid storage pipe
10 can be in hollow cuboid, hollow multiedge cylinder etc..Thus, it is possible to adapt to the liquid collection of specimens of different purposes.
In some instances, the bottom of liquid storage pipe 10 can be flat, and thus, it is possible to be conducive to the placement of liquid storage pipe 10.
In addition, in some instances, the bottom of liquid storage pipe 10 can also be indent, in this case, be equally beneficial for liquid storage pipe
10 placement.
In some instances, liquid storage pipe 10 can be made of materials such as plastics, glass or metals.Face as a result, actual
In bed application, the operating personnel such as doctor can be directed to the liquid storage pipe 10 of different liquid sample selection different materials.
In some instances, liquid storage pipe 10 can be transparent tube body.Thereby, it is possible to facilitate the operating personnel such as doctor real-time
Observe the acquisition situation of the liquid sample of liquid storage pipe in ground.In some instances, liquid storage pipe 10 can be transparent glass tube or modeling
Expects pipe.In addition, in some instances, scale can be provided in liquid storage pipe 10.For example, being provided in the outer surface of liquid storage pipe 10
Indicate the scale of liquid storage pipe capacity.In this case, the operating personnel such as doctor can learn the acquisition of liquid sample in real time
Amount.
In some instances, the scale on liquid storage pipe 10 can be arranged along the outer surface of liquid storage pipe 10, the reading of scale
Be sequentially increased since the bottom of liquid storage pipe 10, for example, 0 μ L, 5 μ L, 10 μ L ..., 100 μ L, 200 μ L etc..But the disclosure is unlimited
In this, such as the reading of scale can also be since the junction with diversion tube 20 of liquid storage pipe 10 to the bottom of liquid storage pipe 10
Be sequentially increased, for example, 0 μ L, 5 μ L, 10 μ L ..., 100 μ L, 200 μ L etc..
In some instances, the liquid sample that harvester 1 is acquired can be the aqueous humor of intraocular.In this case,
Can automatic collection easily be carried out to the aqueous humor of intraocular by negative pressure (being less than intraocular pressure) characteristic in liquid storage pipe 10.
In the clinical operation of ophthalmology, the general difficulty of acquisition of liquid sample is larger, for example, aqueous humor collection capacity such as one
As be no more than 100 μ L, therefore, how to ensure the dosage of acquired liquid sample, avoid excessive acquire etc. to be always that ophthalmology faces
The difficulty faced in bed.It in the present embodiment, can effectively gram by using the negative pressure harvester 1 controlled with valve
Take above-mentioned difficulties, it is ensured that doctor etc. can safely and reliably collect the dosage of the liquid sample such as required aqueous humor.
When in some instances, for being used for harvester 1 to acquire intraocular aqueous humor, the collection capacity of aqueous humor is less for example only
Liquid storage pipe 10 can be arranged to long and narrow at this point, in order to effectively read the seal cavity 11 of event liquid storage pipe 10 for 20~100 μ L
Shape, the floor space that the seal cavity 11 of liquid storage pipe 10 is also arranged to inner cavity are small and highly big.
In some instances, in the outer surface of liquid storage pipe 10, anti-slipping mechanism can be provided with.Thereby, it is possible to facilitate doctor
Equal operating personnel remove liquid storage pipe 10.In other examples, the outer surface of liquid storage pipe 10 can be provided with multiple protrusions, can
Facilitate the operating personnel such as doctor to remove liquid storage pipe 10, liquid storage pipe 10 is avoided to be slid from operating personnel's hand.
In some instances, in addition liquid storage pipe 10 can also configure sealing cover (not shown).For example, when liquid storage pipe 10 acquires
It after complete liquid sample, can be unloaded from diversion tube 20, and liquid storage pipe 10 is covered using sealing cover, thus, it is possible to ensure subsequently to store up
The liquid sample of liquid pipe 10 also allows for the preservation or inspection of the liquid sample of follow-up liquid storage pipe 10 not by outside contamination.
Fig. 4 is the schematic diagram for the diversion tube for showing harvester shown in Fig. 2.Fig. 5 is to show shown in Fig. 2 adopt
The three-dimensional structure diagram of the diversion tube of acquisition means.Fig. 6 is the section signal for the diversion tube for showing the line A-A' along Fig. 5
Figure.
In harvester 1 involved by present embodiment, diversion tube 20 connect and is connected to liquid storage pipe 10, that is,
Access is formed between diversion tube 20 and liquid storage pipe 10 (referring to the Fig. 6 being described later on).Specifically, diversion tube 20 can be with
It is connected to the seal cavity 11 of liquid storage pipe 10, since seal cavity 11 is in negative pressure state, liquid sample can be via leading
Flow tube body 20 and the seal cavity 11 for being flowed into liquid storage pipe 10.
In some instances, diversion tube 20 can form Rule with liquid storage pipe 10 and connect.For example, the one of diversion tube 20
End is that female Luer is connect with the formation of liquid storage pipe 10 Rule.In this case, diversion tube 20 can be removably installed in
Liquid storage pipe 10.
In addition, there is diversion tube 20 directed fluid inlet 21, diversion outlet 22 and setting to go out with water conservancy diversion in directed fluid inlet 21
Valve 23 between mouth 22.
In the present embodiment, directed fluid inlet 21 can connect with penetrating member 30 and (be described later on), and diversion outlet 22 can
To be connected to liquid storage pipe 10, and opening and closing is controlled by valve 23 between directed fluid inlet 21 and diversion outlet 22.In such case
Under, (penetrating member 30 can be especially to be pierced into penetrating member 30 to control liquid storage pipe 10 conveniently by control valve 23
Organizer in liquid sample) connection and closure.
As described above, in diversion tube 20, valve 23 can control the connection of directed fluid inlet 21 and diversion outlet 22 with
It closes.In addition, the extended line L1 of directed fluid inlet 21 and the extended line L2 of diversion outlet 22 are formed with angle theta (referring to Fig. 4).One
In a little examples, it can be angle theta that the extended line of directed fluid inlet 21 and the extended line of diversion outlet 22, which are formed by angle, to be
30~330 degree.In this case, doctor etc. can be conveniently operated penetrating member 30, inhibit liquid storage pipe 10 and diversion tube 20
To penetrating member 30 in operation caused by harmful effect.
In addition, in other examples, the extended line of directed fluid inlet 21 is formed by folder with the extended line of diversion outlet 22
Angle θ can be 30~120 degree or 180~300 degree.In other examples, extended line and the diversion outlet 22 of directed fluid inlet 21
Extended line be formed by angle theta can be 90 degree or 270 degree (referring to Fig. 4), so, it is easier to the operating personnel such as doctor operation
Harvester 1.
In some instances, liquid storage pipe 10 is removably connect with diversion tube 20.The liquid mark of liquid storage pipe 10 is waited for as a result,
This acquisition finishes, and can easily be separately separated liquid storage pipe 10, directly carry out subsequent detecting step.For example, can will store up
Liquid pipe 10 is disassembled from diversion tube 20, and the liquid storage pipe 10 with liquid sample is directly carried out subsequent medicine inspection
It surveys, thus, it is possible to save detection time, improves the efficiency of clinical treatment.In some instances, valve 23 can be push type
Machinery valve.In this case, the operating personnel such as doctor can be facilitated to operate the valve 23 of diversion tube, to side
Just the acquisition of liquid sample is controlled.Specifically, the operating personnel such as doctor can be controlled by easily pressing valve 23
Thus the automatic collection of liquid sample improves the clinical operation efficiency of doctor etc..
As shown in Figure 5 and Figure 6, in the present embodiment, valve 23 substantially may include press head 231 and press head 231
The body of rod 232 of connection, the inner cavity coordinated with the body of rod 232, the sealing ring 233 for being separately positioned on 232 different location of the body of rod and sealing
Circle 234 and the setting elastomeric element 235 in inner cavity 236.
In some instances, press head 231 can be round pie, thus, it is possible to facilitate the operating personnel such as doctor to touch, side
Just it carries out the operation such as pressing.In addition, as shown in Fig. 2, showing press head 231 in the situation of the side of valve 23, but the disclosure
Without being limited thereto, in some instances, the other side of valve 23 can also be arranged in press head 231.
In valve 23, change elastomeric element 235 by pressing press head 231, at least exist provided with the body of rod 232
First position in inner cavity 236 and the second position.Such as when the body of rod 232 squeezes spring 235 and is in first position, water conservancy diversion enters
One end 21a of mouth 21 and one end 22a of diversion outlet 22 are between sealing ring 233 and sealing ring 234, in this case,
Directed fluid inlet 21 is connected with diversion outlet 22 via space 236, and liquid storage pipe 10 is via directed fluid inlet 21, diversion outlet 22 and thorn
Component 30 is worn to be connected to extraneous (organizer)；Such as when the body of rod 232 squeezes spring 235 and is in the second position, such as water conservancy diversion
One end 21a of entrance 21 is between sealing ring 233 and sealing ring 234, in this case, directed fluid inlet 21 and diversion outlet
22 are not connected to, and liquid storage pipe 10 is isolated from the outside.It in this way, can be by press head 231 come the unlatching of control valve 23
And closing, to easily control with subnormal ambient liquid storage pipe 10 with the external world connection and be isolated.
In the present embodiment, the constituent material of valve 23 is not particularly limited, and in some instances, valve 23 can be
It is made of materials such as plastics, glass or metals.From the point of view of durable, valve 23 preferably uses metal material.
In addition, in diversion tube 20, it is also provided with the airtight stopper 24 for liquid storage pipe 10 to be embodied as to negative pressure.Tool
For body, in the case where diversion tube 20 (being specifically the diversion outlet 22 of diversion tube 20) is connected to liquid storage pipe 10, pass through
Such as needle tubing penetrates airtight stopper 24 to the access of diversion outlet 22, and (directed fluid inlet at this time is closed keeping valve 23
21 are not connected to diversion outlet 22) in the case of carry out vacuumize process, thereby, it is possible to easily make the seal chamber of liquid storage pipe 10
Body 11 forms the environment of defined subnormal ambient such as less than intraocular pressure.
In addition, airtight stopper 24 can also maintain 10 negative pressure of liquid storage pipe.Specifically, due to extracting vacuum via airtight stopper 24
Afterwards, since airtight stopper 24 still is able to restore original state, the clogging access, therefore, airtight stopper 24 still are able to maintain liquid storage pipe
10 subnormal ambient.In some instances, airtight stopper 24 can be rubber stopper.
In addition, as described above, liquid storage pipe 10 is connect with diversion tube 20, and airtight stopper 24 is formed in leading for diversion tube 20
One end of outflux 22, in order to ensure airtight stopper 24 can be utilized to implement the Negative pressure entrance of liquid storage pipe 10, in liquid storage pipe
10 need the part at least exposing airtight stopper 24 when being connect with diversion tube 20, the needle tubing for example to extract vacuum can
Penetrate airtight stopper 24.
In some instances, sealing ring 233 and sealing ring 234 can be made of medical grade rubber such as silica gel.At other
In example, sealing ring 233 and sealing ring 234 can also be by other medical material structures such as plastics, glass resin, synthetic compounds
At.The requirement that thereby, it is possible to ensure the air-tightness of valve 23 while ensuring to meet medical instrument for material.
In addition, in some instances, valve 23 or electrically operated valve.For example, the valve can detect air pressure simultaneously
Or the variation of hydraulic pressure, when detecting that air pressure or hydraulic pressure are less than some value after electrically operated valve unlatching, electrically operated valve is automatically closed, and makes
Directed fluid inlet 21 is not connected to diversion outlet 22.It in this case, being capable of more convenient operating personnel's operation valve 23.
Fig. 7 is the three-dimensional structure diagram for the penetrating member for showing the harvester involved by embodiments of the present invention.Fig. 8
It is the usage state diagram for the penetrating member for showing the harvester involved by embodiments of the present invention.Fig. 9 is to show this
The three-dimensional structure diagram of the upper shield of harvester involved by the embodiment of invention.Figure 10 is to show embodiments of the present invention
The schematic diagram of the access of involved harvester.In fig. 8, example is applied for convenience, shows harvester 1 for adopting
Collect the example of the aqueous humor in eyeball 2, however, the present invention is not limited thereto.
As shown in fig. 7, penetrating member 30 may include main body 31 and the puncture portion 32 being connect with main body 31.In addition, main body
31 can be connected to puncture portion 32, and thus liquid sample can flow through penetrating member 30 and reach diversion tube 20.
In some instances, in penetrating member 30, be formed between main body 31 and puncture portion 32 narrow access (referring to
Figure 10), thus, it is possible to ensure liquid sample to make because residing in main body 31 or puncture portion 32 flowing through penetrating member 30
It is lost at liquid sample.This structure is especially suitable for for the situation measured few liquid sample such as aqueous humor and extracted.
In some instances, penetrating member 30 can form Rule with diversion tube 20 and connect.Such as diversion tube 20
Female Luer is formed close to one end of directed fluid inlet 21 and is formed Rule with penetrating member 30 and is connect.
In addition, in some instances, penetrating member 30 can be formed as one molding with diversion tube 20.In such case
Under, penetrating member 30 can be from the part that diversion tube 20 is drawn.
In some instances, in penetrating member 30, the restricted position-limit mechanism 33 for piercing through position can be set.It is specific and
The restricted position-limit mechanism 33 for piercing through position is arranged in speech between the main body 31 and puncture portion 32 of penetrating member 30.In this feelings
Under condition, when doctor etc., which will puncture through component 30, is pierced into organizer, puncture (piercing) position of penetrating member 30 is limited, it is possible thereby to
Convenient for the equal depth for controlling penetrating member 30 when acquiring aqueous humor and entering of doctor, penetrating member can be more accurately controlled
30 puncture position effectively avoids enter into too deep and patient is caused to receive secondary injury, improves the reliability of operation.
Here, it refers to the position that penetrating member 30 is pierced into organizer to pierce through position, specifically, containing liquid by being pierced into
The organizer of sample so that the liquid sample in organizer is connected to the seal cavity 11 of liquid storage pipe 10, then passes through liquid storage pipe
10 negative pressure and in organizer liquid sample carry out automatic collection.
Penetrating member 30 shown in Fig. 8 is pierced into the example for obtaining aqueous humor sample in eyeball 2, and rainbow should be avoided by piercing through position
The position of film and cornea causes to damage to avoid to above-mentioned tissue.In addition, it is necessary to explanation, penetrating member shown in Fig. 8
Before 30 operation direction is only example effect, such as penetrating member 30 can also be with iris substantially in parallel direction piercing eyeball
Room is to obtain aqueous humor sample.
In some instances, position-limit mechanism 33 can be designed to fit in the surface of organizer, and thus, it is possible to play to pierce
The puncture portion 32 for wearing component 30 is self aligned to pierce through position.Thus, it is possible to facilitate the operating personnel such as doctor to carry out puncture operation.
In some instances, penetrating member 30 can have protrusion 34.By protrusion 34, can easily will puncture through
Component 30 disassembles or will puncture through component 30 from diversion tube 20 and is installed on diversion tube 20.Protrusion 34 can be provided with phase
To two, more convenient can will puncture through component 30 in this way and disassemble or will puncture through component 30 from diversion tube 20 and be installed on
Diversion tube 20.
In some instances, penetrating member 30 can also be in alongst by contracting shape.Thus, it is possible to facilitate doctor
The operating personnel such as raw carry out the puncture to organizer, improve reliability and stability.
In addition, in some instances, penetrating member 30 can be needle tubing.In this case, since the front end of needle tubing is
It is tip-shape, therefore can be easy to pierce through organizer such as eyeball.Thereby, it is possible to facilitate the operating personnel such as doctor to pierce through organizer
Carry out the acquisition of liquid sample.
In some instances, the syringe needle outer diameter as the needle tubing of penetrating member 30, can be 0.31-4.57mm, in syringe needle
Diameter can be 0.15-3.81mm.Acquisition for the liquid sample such as ophthalmology, the syringe needle outer diameter of needle tubing be preferably 0.31mm extremely
0.64mm, internal diameter are preferably 0.15mm to 0.33mm, can either effectively acquire liquid sample as a result, also can realize wound most
Smallization accomplishes that safety is minimally invasive and makes a collection of specimens.
As described above, liquid storage pipe 1, diversion tube 2 and penetrating member 3 connect and are formed with narrow access (such as Figure 10 institutes
Show), thus liquid sample can be via penetrating member 3, diversion tube 2 and by automatic collection to liquid storage pipe 1.In such case
Under, liquid sample as much as possible can either be effectively collected, can also realize that wound minimizes, accomplishes the minimally invasive collection mark of safety
This.
In addition, in the present embodiment, the length in the puncture portion 32 of penetrating member 30 is not particularly limited, such as eye
For the liquid sample such as aqueous humor of section, the anterior chamber of eyes and the deep enough anterior chamber of energy can be pierced into.
In the present embodiment, harvester 1 can also have upper shield 40 (referring to Fig. 3).In some instances, upper shield 40
It is removably installed in penetrating member 30.As shown in Figure 3 and Figure 9, by by liquid storage pipe 10, diversion tube 20, penetrating member 30
It is fitted together with upper shield 40, so as to ensure that harvester 1 is in protected state, penetrating member 40 is avoided to accidentally injure doctor
Equal operating personnel.In addition, upper shield 40 can prevent penetrating member 30 by pollutions such as dusts with blocks dust.
In some instances, upper shield 40 can be the airtight cover for being covered in penetrating member 30.Thus, it is possible to further ensure that
The negative pressure state of liquid storage pipe 10.
In addition, in some instances, upper shield 40 can also cover penetrating member 30 and valve 23 simultaneously.In such case
Under, valve 23 can also obtain the protection of upper shield 40, and valve 23 is avoided to be misused.Here, the tail end of upper shield 40 can be according to valve
The structure of door 23 makees the adjustment of adaptability, so as to matchingly cover valve 23.
In some instances, upper shield 40 can be made of materials such as plastics, glass, metals.In some instances, upper shield 40
Can be in the various shapes such as cylinder, cuboid, multiedge cylinder or anomalistic object.
In some instances, it is also provided with skid resistance strip in the outer wall of upper shield 40 (referring to Fig. 9).In some examples
In, skid resistance strip 41 can be provided with a plurality of, such as the peripheral direction of upper shield 40 be provided with four, eight or 12
Deng.In some instances, skid resistance strip 41 can be arranged along the length direction of upper shield 40, be formed as strip.
In addition, in other examples, protrusion is also provided in the outer wall of upper shield 40.In other examples, set
The outer wall of lid 40 is also provided with Anti-slip cover.Thereby, it is possible to prevent from skidding in use.
Although being illustrated to the present invention above in association with drawings and examples, it will be appreciated that above description
The invention is not limited in any way.Those skilled in the art without departing from the true spirit and scope of the present invention may be used
To deform and change to the present invention as needed, these deformations and variation are within the scope of the present invention.
For example, in harvester 1, the extended line of directed fluid inlet 21 is formed by angle with the extended line of diversion outlet 22
θ is 180 degree, that is, diversion tube 20 is formed as strip.At the same time, penetrating member 30 (is specifically the thorn of penetrating member 30
Wear portion 32) shape of bending can be arranged to, as shown in figure 11.In this case, the puncture portion 32 of penetrating member 30 can be with
With bending part 321.Doctor etc. can promote diversion tube 20 from different perspectives as a result, and this structure is especially suitable for intraocular
The acquisition of liquid sample such as aqueous humor.
In some instances, the bending angle of bending part 321 can be such as 30 degree, 45 degree, 60 degree, 90 degree.One
In a little examples, bending part 321 can be made of memory metal material.Thus, it is possible to the angle of bending according to circumstances be adjusted, with suitable
Answer the acquisition of different parts.
Claims (10)
1. a kind of harvester of the liquid sample with valve, which is characterized in that
Including：
Liquid storage pipe, with seal cavity, the air pressure of the seal cavity is negative pressure；
Diversion tube is connected to the seal cavity of the liquid storage pipe, and is existed with directed fluid inlet, diversion outlet and setting
Valve between the directed fluid inlet and the diversion outlet, the valve control the directed fluid inlet and the diversion outlet
Connection and closing, and the extended line of the directed fluid inlet and the extended line of the diversion outlet are formed with angle；And
Penetrating member is used to pierce through organizer, and is connected to the directed fluid inlet of the diversion tube.
2. harvester as described in claim 1, which is characterized in that
The liquid storage pipe is removably connect with the diversion tube.
3. harvester as described in claim 1, which is characterized in that
The valve is the machinery valve of push type.
4. harvester as described in claim 1, which is characterized in that
The liquid sample is the aqueous humor of intraocular.
5. harvester as claimed in claim 4, which is characterized in that
In the penetrating member, the restricted position-limit mechanism for piercing through position is set.
6. harvester as described in claim 1, which is characterized in that
The extended line of the extended line of the directed fluid inlet and the diversion outlet be formed by angle be 30~120 degree or 180~
330 degree.
7. harvester as described in claim 1, which is characterized in that
The liquid storage pipe is transparent tube body.
8. harvester as claimed in claim 7, which is characterized in that
In the liquid storage pipe, it is provided with scale.
9. harvester as described in claim 1, which is characterized in that
It further include the upper shield for being removably covered in the penetrating member.
10. harvester as described in claim 1, which is characterized in that
The penetrating member is needle tubing.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810323046.5A CN108433748A (en) | 2018-04-11 | 2018-04-11 | The harvester of liquid sample with valve |
| CN202110264735.5A CN113143332B (en) | 2018-04-11 | 2018-10-27 | Push type liquid specimen collecting device |
| CN201811262141.5A CN109363726B (en) | 2018-04-11 | 2018-10-27 | Liquid specimen collecting device with valve |
| CN202110267797.1A CN113143333B (en) | 2018-04-11 | 2018-10-27 | Collection device for intraocular liquid specimen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810323046.5A CN108433748A (en) | 2018-04-11 | 2018-04-11 | The harvester of liquid sample with valve |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108433748A true CN108433748A (en) | 2018-08-24 |
Family
ID=63199683
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810323046.5A Pending CN108433748A (en) | 2018-04-11 | 2018-04-11 | The harvester of liquid sample with valve |
| CN202110264735.5A Active CN113143332B (en) | 2018-04-11 | 2018-10-27 | Push type liquid specimen collecting device |
| CN201811262141.5A Active CN109363726B (en) | 2018-04-11 | 2018-10-27 | Liquid specimen collecting device with valve |
| CN202110267797.1A Active CN113143333B (en) | 2018-04-11 | 2018-10-27 | Collection device for intraocular liquid specimen |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110264735.5A Active CN113143332B (en) | 2018-04-11 | 2018-10-27 | Push type liquid specimen collecting device |
| CN201811262141.5A Active CN109363726B (en) | 2018-04-11 | 2018-10-27 | Liquid specimen collecting device with valve |
| CN202110267797.1A Active CN113143333B (en) | 2018-04-11 | 2018-10-27 | Collection device for intraocular liquid specimen |
Country Status (1)
| Country | Link |
|---|---|
| CN (4) | CN108433748A (en) |
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| CN108652680A (en) * | 2018-04-11 | 2018-10-16 | 吴飞 | A kind of sampling detecting device for eyeball |
| WO2019196175A1 (en) * | 2018-04-11 | 2019-10-17 | 中山大学中山眼科中心 | Liquid sample collection apparatus with valve |
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- 2018-10-27 CN CN202110264735.5A patent/CN113143332B/en active Active
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108652680A (en) * | 2018-04-11 | 2018-10-16 | 吴飞 | A kind of sampling detecting device for eyeball |
| WO2019196175A1 (en) * | 2018-04-11 | 2019-10-17 | 中山大学中山眼科中心 | Liquid sample collection apparatus with valve |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113143333B (en) | 2022-08-05 |
| CN113143333A (en) | 2021-07-23 |
| CN109363726A (en) | 2019-02-22 |
| CN113143332B (en) | 2022-08-05 |
| CN109363726B (en) | 2021-03-30 |
| CN113143332A (en) | 2021-07-23 |
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Application publication date: 20180824 |
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