CN109350715A - A kind of antipruritic tincture liniment and preparation method thereof - Google Patents

A kind of antipruritic tincture liniment and preparation method thereof Download PDF

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CN109350715A
CN109350715A CN201711079810.0A CN201711079810A CN109350715A CN 109350715 A CN109350715 A CN 109350715A CN 201711079810 A CN201711079810 A CN 201711079810A CN 109350715 A CN109350715 A CN 109350715A
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parts
liniment
acid
antipruritic
alcohol
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李永辉
李福印
黄春萌
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Abstract

The invention discloses a kind of antipruritic tincture liniments and preparation method thereof, the antipruritic tincture liniment includes the component of following parts by weight: 40~50 parts of cassia bark, 40~50 parts of rheum officinale, 30~40 parts of kuh-seng, 30~40 parts of cortex dictamni, 30~40 parts of Cortex Phellodendri, 30~40 parts of azedarach, 40~50 parts of the tuber of stemona, 30~40 parts of the fruit of summer cypress, 30~40 parts of rhizoma polygonati, 30~40 parts of pericarpium zanthoxyli, 30~40 parts of frutus cnidii, 30~40 parts of Asian puccoon, 0.5~1 part of benzoic acid, 0.5~1 part of salicylic acid, 0.3~0.5 part of carbolic acid, pungent 0.5~1 part of thunder lock, 0.5~1 part of camphor, 0.5~1 part of menthol, 0.5~1 part of borneol, 3~5 parts of glycerol, 1~2 part of gentamicin, 1~2 part of lincomycinum.It is raw material that the present invention antipruritic tincture liniment, which selects the Chinese medicine for being conducive to sterilizing, it not only has no toxic side effect, securely and reliably, and the materials such as addition benzoic acid, Lei Suoxin, carbolic acid, salicylic acid, camphor, gentamicin and lincomycinum therein can significantly increase the curative effect of the antipruritic tincture liniment, it can be widely applied to such as: the treatment for the treatment of dermatitis, eczema, bite by mosquitos, fungi tinea pedis, jock itch, ringworm of the body, pruitus disease, great market application and promotional value.

Description

A kind of antipruritic tincture liniment and preparation method thereof
Technical field
The invention belongs to treat the technical field of pharmaceuticals of pruitus disease, it is related to a kind of antipruritic tincture liniment and its production side In particular method is a kind of pro-skin itch-stopping tincture as externally applied medicine for treating pruitus.
Background technique
The drug that ringworm of the body and pruitus use is treated for people at present, it is various in style, it works well, but it treats function Single, therapeutic domain is confined to a certain skin tinea and cutaneous pruritus.In order to meet the Treatment need of different patients, just must It must select to be treated for certain skin tinea and the drug of cutaneous pruritus, various ringworm of the body can be treated by manufacturing one kind, The antipruritic tincture spray of various cutaneous pruritus can be treated again to meet the needs of people's treatment.
In addition, cutaneous pruritus, neurodermatitis, chronic eczema etc., are the common illnesss of skin disease, caused by itch Scratching, makes skin proliferation thicken, and forms stimulation to the sensory nerve of skin, aggravates itch, is formed more to itch and more be grabbed, aggravated original The skin state of an illness expands skin lesion range, accelerates pathological process.The specific medicament for treating itch is seldom, and most is to contain hormone Western medicine, long-time service be also easy to produce the adverse reactions such as drug resistance and allergy.
Therefore, how a kind of antipruritic tincture liniment have no toxic side effect, is significant in efficacy, having a wide range of application and its production side are provided The problem of method is those skilled in the art's urgent need to resolve.
Summary of the invention
In view of this, a kind of antipruritic the technical problem to be solved by the present invention is to overcome the deficiencies of the prior art and provide Tincture liniment and preparation method thereof, it is raw material which, which selects the Chinese medicine for being conducive to sterilizing, has purging fire for removing toxin, cool blood Detumescence, enhancing antifungal activity, significant antimycotic effect, and have no toxic side effect, securely and reliably, it can be widely applied to skin scabies The treatment for disease of itching.
To achieve the goals above, the invention provides the following technical scheme:
A kind of antipruritic tincture liniment, the component including following parts by weight: 40~50 parts of cassia bark, 40~50 parts of rheum officinale, kuh-seng 30~40 parts, 30~40 parts of cortex dictamni, 30~40 parts of Cortex Phellodendri, 30~40 parts of azedarach, 40~50 parts of the tuber of stemona, the fruit of summer cypress 30~40 Part, 30~40 parts of rhizoma polygonati, 30~40 parts of pericarpium zanthoxyli, 30~40 parts of frutus cnidii, 30~40 parts of Asian puccoon, 0.5~1 part of benzoic acid, bigcatkin willow 0.5~1 part of acid, 0.3~0.5 part of carbolic acid, thunder lock pungent 0.5~1 part, 0.5~1 part of camphor, 0.5~1 part of menthol, borneol 0.5~1 part, 3~5 parts of glycerol, 1~2 part of gentamicin, 1~2 part of lincomycinum.
Preferably, in a kind of above-mentioned antipruritic tincture liniment, the component including following parts by weight: including following parts by weight Component: 45 parts of cassia bark, 45 parts of rheum officinale, 35 parts of kuh-seng, 35 parts of cortex dictamni, 35 parts of Cortex Phellodendri, 35 parts of azedarach, 45 parts of the tuber of stemona, 35 parts of skin, 30 parts of rhizoma polygonati, 32 parts of pericarpium zanthoxyli, 35 parts of frutus cnidii, 35 parts of Asian puccoon, 0.6 part of benzoic acid, 0.6 part of salicylic acid, carbolic acid 0.4 part, it is 0.8 part of resorcinol, 0.6 part of camphor, 0.8 part of menthol, 0.6 part of borneol, 4 parts of glycerol, 1.6 parts of gentamicin, clean mould 1.2 parts of element.
A kind of production method of antipruritic tincture liniment, includes the following steps:
(1) it weighs Chinese medicine: weighing the component of following parts by weight: 40~50 parts of cassia bark, 40~50 parts of rheum officinale, kuh-seng respectively 30~40 parts, 30~40 parts of cortex dictamni, 30~40 parts of Cortex Phellodendri, 30~40 parts of azedarach, 40~50 parts of the tuber of stemona, the fruit of summer cypress 30~40 Part, 30~40 parts of rhizoma polygonati, 30~40 parts of pericarpium zanthoxyli, 30~40 parts of frutus cnidii, 30~40 parts of Asian puccoon, mix, are mixed Material；
(2) it first time alcoholic extraction: measures 2500mL, the alcohol that purity is 75%~95%, the alcohol is poured into body Product than be 2:1 water in, be uniformly mixed and obtain alcohol weak solution, and the alcohol weak solution poured into weighed through step (1) In Chinese medicine, sealed soak is handled 72 hours, and it is spare to obtain the first extracting solution for filtering；
(3) second of alcoholic extraction: it measures 2500mL, the alcohol that purity is 75%~95%, the alcohol is poured into body Product ratio is to be uniformly mixed in the water of 2:1 and obtain alcohol weak solution, and the alcohol weak solution is poured into and filters institute through step (2) In the filter residue obtained, sealed soak is handled 24 hours, and it is spare to obtain the second extracting solution for filtering；
(4) mixing is removed slag: the second extracting solution that step (3) obtains is added in the first extracting solution that step (2) obtains, It rocks, be uniformly mixed, filter and remove residue, it is spare；
(5) weigh material: weighing the component of following parts by weight respectively: 0.5~1 part of benzoic acid, 0.5~1 part of salicylic acid, 0.3~0.5 part of carbolic acid, thunder lock pungent 0.5~1 part, 0.5~1 part of camphor, 0.5~1 part of menthol, 0.5~1 part of borneol, glycerol 3~5 parts, 1~2 part of gentamicin, 1~2 part of lincomycinum；
(6) the weighed benzoic acid of step (5), salicylic acid and carbolic acid dissolution mixing: are dissolved in step (4) resulting mixing In liquid, it is sufficiently stirred and is added glycerol dilution dissolution, extracts supernatant after standing 24 hours；
(7) sub-bottle is filling: will extract resulting supernatant through step (6) and be added in liquid quantitative filling machine, and according to 10 It is filling that~30mL packing specification carries out sub-bottle.
Preferably, in a kind of above-mentioned production method of antipruritic tincture liniment, step (1) weighs following important number respectively Component: 40~50 parts of cassia bark, 40~50 parts of rheum officinale, 30~40 parts of kuh-seng, 30~40 parts of cortex dictamni, 30~40 parts of Cortex Phellodendri, China tree 30~40 parts of skin, 40~50 parts of the tuber of stemona, 30~40 parts of the fruit of summer cypress, 30~40 parts of rhizoma polygonati, 30~40 parts of pericarpium zanthoxyli, frutus cnidii 30~40 Part, 30~40 parts of Asian puccoon.
Preferably, in a kind of above-mentioned production method of antipruritic tincture liniment, step (6) weighs following parts by weight respectively Component: 0.5~1 part of benzoic acid, 0.5~1 part of salicylic acid, 0.3~0.5 part of carbolic acid, thunder lock pungent 0.5~1 part, camphor 0.5~1 Part, 0.5~1 part of menthol, 0.5~1 part of borneol, 3~5 parts of glycerol, 1~2 part of gentamicin, 1~2 part of lincomycinum.
It preferably, include following in a kind of above-mentioned production method of antipruritic tincture liniment, between step (6) and step (7) Step: before the antipruritic tincture liniment to be used, camphor, menthol, borneol, gentamicin and lincomycinum that step (5) is obtained It is added to and is extracted in resulting supernatant through step (6) jointly, be sufficiently stirred, be uniformly mixed.
It should be noted that since the material pesticide effects such as camphor, menthol, borneol, gentamicin are unstable, when with storage Between extension, efficacy can reduce accordingly.Therefore, we select, before using the antipruritic tincture liniment, on resulting The above substance is added in clear liquid, to retain efficacy.
Preferably, in a kind of above-mentioned production method of antipruritic tincture liniment, the drug effect of various Chinese medicines are as follows:
Cassia bark: not only fragrant aroma can make meat dish raw meat solution of dispelling greasy, make us appetite and increase；And it is appropriate in dish Add cassia bark, help to prevent or delay with age caused by type-2 diabetes mellitus；And contain derived from phenyl acrylic acid in cassia bark Object is closed, has therapeutic effect to hyperplasia of prostate.
Rheum officinale: external application energy purging fire for removing toxin, cool blood detumescence control heat toxin carbuncle swells malignant boil furuncle.
Kuh-seng: it is cold in nature, there is the effect of heat-clearing and damp-drying drug, desinsection.Kuh-seng bath can remove damp-heat in lower-JIAO, and desinsection is antipruritic, There is good relaxation effect to pruitus.In addition, kuh-seng ether extract and alcohol extract have stronger suppression to staphylococcus aureus Bacterium effect；And kuh-seng flooding agent is to trichophyton, Trichophyton concentricum, Trichophyton schoenleini, Du small gemma tinea bacterium of big belly difficult to understand etc. There is inhibiting effect.
Cortex dictamni: having an antibacterial action, and the infusion of in vitro test 1:4 is to a variety of pathomycetes such as trichophyton, same Disposition trichophyta, oidium schoenleinii have different degrees of inhibiting effect.
Cortex Phellodendri: being used for damp-heat dysentery, and jaundice and reddish urine, leukorrhagia pruritus vulvae, puckery pain of heat gonorrhea, tinea pedis impotence is preesed, hectic fever due to yin labor heat, night sweat, Spermatorrhea, sore swollen toxin, eczema wet sore.
Azedarach: roundworm disease, enterobiasis and abdominal pain due to enterositosis are used for；Scabies itch is controlled outside.
The tuber of stemona: gentle lung qi, cough-relieving, desinsection.Cough due to wind-cold evil, pertussis, pulmonary tuberculosis and old cough and asthma and ascarid can be treated Worm, enterobiasis, skin scabies and eczema.
The fruit of summer cypress: diuresis, clearing away damp-heat.It is wet to control difficult urination, stranguria syndrome, leukorrhagia, hernia, rubeola, sore, scabies and private parts Itch.
Rhizoma polygonati: having the effects of blood pressure lowering, hypoglycemic, reducing blood lipid, atherosclerosis, anti-aging and antibacterial, Wherein Siberian solomonseal rhizome polysaccharide has Immunestimulatory effect.It is applied not only to the lung-dryness syndrome due to yin deficiency, dry cough lacks the overstrain cough chronic cough etc. of phlegm and lung-kidney deficiency, It is also used to weakness of the spleen and the stomach.Not only tonifying spleen-yin, but also beneficial temper, obtain dizzy, soreness and weakness of waist and knees for deficiency of kidney essence, poliosis and quench one's thirst Deng.
Pericarpium zanthoxyli: function Wei's line water detumescence；It is swollen to cure mainly fullness and oppression of chest and abdomen, difficult urination, skin.
Frutus cnidii: there is antifungic action, Osthole, bergapten and isopimpinellin in vitro test pair therein The trichophyton mentagrophytes of trichophyte have strong activity；And xanthotoxol therein has significant Antifungal activities.
Asian puccoon: being a kind of Chinese medicine, and nature and flavor are sweet, salty, has clearing heat and cooling blood, promoting blood circulation, removing toxic substances promoting eruption and other effects.
It can be seen via above technical scheme that compared with prior art, the present disclosure provides a kind of antipruritic tincture liniments And preparation method thereof, selecting the Chinese medicine for being conducive to sterilizing first is raw material, has purging fire for removing toxin, cool blood detumescence, enhancing anti-true Bacterium activity, significant antimycotic effect, and have no toxic side effect, securely and reliably, it can be widely applied to the treatment of pruitus disease；
Secondly, Chinese medicine is directly crushed to powder, mixed liquor is obtained by alcoholic extraction, reagent (benzoic acid, bigcatkin willow is added The materials such as acid, camphor, menthol, Lei Suoxin, carbolic acid) dissolution mixing, and the filling antipruritic tincture that obtains of supernatant sub-bottle is taken to wipe Agent, not only operating procedure is simple, cost of material is low, but also technological parameter therein and raw material composition proportion are that inventor consults greatly Amount data combination a large number of experiments is summarized and is obtained, and has real reliability, significant in efficacy with the antipruritic tincture liniment for guaranteeing prepared；
Then, by selecting benzoic acid to combine with salicylic acid, it can treat adult skin nosomycosis, mycotic infection of superficial part is such as The diseases such as ringworm of the body, the tinea manuum and tinea pedis；And camphor, menthol and the borneol wherein added can not only be used for the antipruritic tincture liniment Odorant, and there is swelling and pain relieving, refrigerant antipruritic effect；And the glycerol of addition can dissolve in any proportion with water, it is low Concentration glycerin solution be used as lubricating oil skin is carried out it is moist；In addition, addition gentamicin and lincomycinum belong to it is antibacterial Agent slowly can decompose in an acidic solution and generate formaldehyde to play the role of to affected skin sterilizing；
Finally, be applied not only to treatment eczema, pruigo by the antipruritic tincture liniment that is prepared of the present invention, and to it is bite, Nerve and seborrhea have significant curative effect, and can be applied to and the diseases such as mushroom skin disease and fungal dermatosis are controlled It treats.
The present invention integrates easy to operate, low in cost, is raw material by selecting the Chinese medicine for being conducive to sterilizing, not only It has no toxic side effect, securely and reliably, and adds the materials energy such as benzoic acid, salicylic acid, camphor, gentamicin and lincomycinum therein The curative effect for enough significantly increasing the antipruritic tincture liniment, can be widely applied to the treatment of pruitus disease, and great market is applied and pushed away Wide value.
Detailed description of the invention
In order to more clearly explain the embodiment of the invention or the technical proposal in the existing technology, to embodiment or will show below There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this The embodiment of invention for those of ordinary skill in the art without creative efforts, can also basis The attached drawing of offer obtains other attached drawings.
Fig. 1 attached drawing is method step flow diagram of the invention.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.It is based on Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall within the protection scope of the present invention.
The embodiment of the invention discloses a kind of antipruritic tincture liniment and preparation method thereof, which, which selects, is conducive to sterilization The Chinese medicine of disinfection is raw material, has no toxic side effect, securely and reliably, can be widely applied to the treatment of pruitus disease, great market Using with promotional value.
Embodiment one
(1) it weighs Chinese medicine: weighing the component of following parts by weight respectively: is 45 parts of cassia bark, 45 parts of rheum officinale, 35 parts of kuh-seng, white 35 parts of fresh hide, 35 parts of Cortex Phellodendri, 35 parts of azedarach, 45 parts of the tuber of stemona, 35 parts of the fruit of summer cypress, 30 parts of rhizoma polygonati, 32 parts of pericarpium zanthoxyli, frutus cnidii 35 Part, 35 parts of Asian puccoon, mix, obtain mixture；
(2) first time alcoholic extraction: 2500mL is measured, the alcohol that purity is 75%, the alcohol, which is poured into volume ratio, is It in the water of 2:1, is uniformly mixed and obtains alcohol weak solution, and the alcohol weak solution is poured into through in step (1) weighed Chinese medicine, Sealed soak is handled 72 hours, and it is spare to obtain the first extracting solution for filtering；
(3) second of alcoholic extraction: 2500mL is measured, the alcohol that purity is 75%, the alcohol, which is poured into volume ratio, is It in the water of 2:1, is uniformly mixed and obtains alcohol weak solution, and the alcohol weak solution is poured into and filters resulting filter through step (2) In slag, sealed soak is handled 24 hours, and it is spare to obtain the second extracting solution for filtering；
(4) mixing is removed slag: the second extracting solution that step (3) obtains is added in the first extracting solution that step (2) obtains, It rocks, be uniformly mixed, filter and remove residue, it is spare；
(5) it weighs material: weighing the component of following parts by weight: 0.6 part of benzoic acid, 0.6 part of salicylic acid, carbolic acid respectively 0.4 part, thunder lock is 0.8 part pungent, 0.6 part of camphor, 0.8 part of menthol, 0.6 part of borneol, 4 parts of glycerol, 1.6 parts of gentamicin, clean mould 1.2 parts of element；
(6) the weighed benzoic acid of step (5), salicylic acid, carbolic acid and Lei Suoxin dissolution mixing: are dissolved in step (4) institute In the mixed liquor obtained, it is sufficiently stirred and is added glycerol dilution dissolution, extracts supernatant after standing 24 hours；
(7) sub-bottle is filling: will extract resulting supernatant through step (6) and be added in liquid quantitative filling machine, and according to 10 It is filling that~30mL packing specification carries out sub-bottle.
In order to further optimize the above technical scheme, the following steps are included: institute to be used between step (6) and step (7) Before stating antipruritic tincture liniment, camphor, menthol, borneol, gentamicin and lincomycinum that step (5) obtains are added to jointly through step Suddenly (6) are extracted in resulting supernatant, are sufficiently stirred, are uniformly mixed.
Embodiment two
(1) it weighs Chinese medicine: weighing the component of following parts by weight respectively: is 48 parts of cassia bark, 48 parts of rheum officinale, 38 parts of kuh-seng, white 38 parts of fresh hide, 38 parts of Cortex Phellodendri, 38 parts of azedarach, 48 parts of the tuber of stemona, 38 parts of the fruit of summer cypress, 38 parts of rhizoma polygonati, 38 parts of pericarpium zanthoxyli, frutus cnidii 38 Part, 38 parts of Asian puccoon, mix, obtain mixture；
(2) first time alcoholic extraction: 2500mL is measured, the alcohol that purity is 85%, the alcohol, which is poured into volume ratio, is It in the water of 2:1, is uniformly mixed and obtains alcohol weak solution, and the alcohol weak solution is poured into through in step (1) weighed Chinese medicine, Sealed soak is handled 72 hours, and it is spare to obtain the first extracting solution for filtering；
(3) second of alcoholic extraction: 2500mL is measured, the alcohol that purity is 85%, the alcohol, which is poured into volume ratio, is It in the water of 2:1, is uniformly mixed and obtains alcohol weak solution, and the alcohol weak solution is poured into and filters resulting filter through step (2) In slag, sealed soak is handled 24 hours, and it is spare to obtain the second extracting solution for filtering；
(4) mixing is removed slag: the second extracting solution that step (3) obtains is added in the first extracting solution that step (2) obtains, It rocks, be uniformly mixed, filter and remove residue, it is spare；
(5) it weighs material: weighing the component of following parts by weight: 0.5 part of benzoic acid, 0.5 part of salicylic acid, carbolic acid respectively 0.3 part, thunder lock is 0.5 part pungent, 0.5 part of camphor, 0.5 part of menthol, 0.5 part of borneol, 3 parts of glycerol, 1.6 parts of gentamicin, clean mould 1.2 parts of element；
(6) the weighed benzoic acid of step (5), salicylic acid, carbolic acid and Lei Suoxin dissolution mixing: are dissolved in step (4) institute In the mixed liquor obtained, it is sufficiently stirred and is added glycerol dilution dissolution, extracts supernatant after standing 24 hours；
(7) sub-bottle is filling: will extract resulting supernatant through step (6) and be added in liquid quantitative filling machine, and according to 10 It is filling that~30mL packing specification carries out sub-bottle.
In order to further optimize the above technical scheme, the following steps are included: institute to be used between step (6) and step (7) Before stating antipruritic tincture liniment, camphor, menthol, borneol, gentamicin and lincomycinum that step (5) obtains are added to jointly through step Suddenly (6) are extracted in resulting supernatant, are sufficiently stirred, are uniformly mixed.
Embodiment three
(1) it weighs Chinese medicine: weighing the component of following parts by weight respectively: is 46 parts of cassia bark, 45 parts of rheum officinale, 34 parts of kuh-seng, white 35 parts of fresh hide, 38 parts of Cortex Phellodendri, 34 parts of azedarach, 45 parts of the tuber of stemona, 32 parts of the fruit of summer cypress, 35 parts of rhizoma polygonati, 34 parts of pericarpium zanthoxyli, frutus cnidii 35 Part, 35 parts of Asian puccoon, mix, obtain mixture；
(2) first time alcoholic extraction: 2500mL is measured, the alcohol that purity is 90%, the alcohol, which is poured into volume ratio, is It in the water of 2:1, is uniformly mixed and obtains alcohol weak solution, and the alcohol weak solution is poured into through in step (1) weighed Chinese medicine, Sealed soak is handled 72 hours, and it is spare to obtain the first extracting solution for filtering；
(3) second of alcoholic extraction: 2500mL is measured, the alcohol that purity is 90%, the alcohol, which is poured into volume ratio, is It in the water of 2:1, is uniformly mixed and obtains alcohol weak solution, and the alcohol weak solution is poured into and filters resulting filter through step (2) In slag, sealed soak is handled 24 hours, and it is spare to obtain the second extracting solution for filtering；
(4) mixing is removed slag: the second extracting solution that step (3) obtains is added in the first extracting solution that step (2) obtains, It rocks, be uniformly mixed, filter and remove residue, it is spare；
(5) it weighs material: weighing the component of following parts by weight: 0.8 part of benzoic acid, 0.8 part of salicylic acid, carbolic acid respectively 0.4 part, thunder lock is 0.6 part pungent, 0.5 part of camphor, 0.8 part of menthol, 0.6 part of borneol, 5 parts of glycerol, 1.6 parts of gentamicin, clean mould 1.2 parts of element；
(6) the weighed benzoic acid of step (5), salicylic acid, carbolic acid and Lei Suoxin dissolution mixing: are dissolved in step (4) institute In the mixed liquor obtained, it is sufficiently stirred and is added glycerol dilution dissolution, extracts supernatant after standing 24 hours；
(7) sub-bottle is filling: will extract resulting supernatant through step (6) and be added in liquid quantitative filling machine, and according to 10 It is filling that~30mL packing specification carries out sub-bottle.
In order to further optimize the above technical scheme, the following steps are included: institute to be used between step (6) and step (7) Before stating antipruritic tincture liniment, camphor, menthol, borneol, gentamicin and lincomycinum that step (5) obtains are added to jointly through step Suddenly (6) are extracted in resulting supernatant, are sufficiently stirred, are uniformly mixed.
Test method:
(1) selection criteria of case:
Select the cutaneous pruritus with obvious pruritis, neurodermatitis, patients with chronic eczema to observe object, altogether Meter observation 60, including male 45, female 15.Age, the course of disease was about 1~2 year between 18~45 years old.
(2) antipruritic effect assessment method:
1, antipruritic effect observation index: (1) itch degree: slight is that can cause to scratch, or restrain and do not scratch；Moderate is Cause to scratch, influences working and learning；Severe unbearably, causes acutely to scratch, influences to sleep for itch.(2) the itch duration And frequency: being slightly transient；Moderate was the duration less than 2 minutes, and breaking-out is infrequently；Severe is the duration to be greater than 2 points Clock, breaking-out are frequent.
2, antipruritic effect evaluation criteria: point-score is used.The above observation index slightly remembers 1 point, and moderate remembers 2 points, severe note 3 Point, such as divide without note 0.With the sum of pre-treatment score, the sum of post treatment integral is subtracted, (0 sub-item is disregarded divided by observation item number Calculate), be greater than or equal to 2 as a result to be excellent, be greater than less than 21 be it is good, it is to be less than or equal to 0 that 0 is greater than less than or equal to 1 Difference.With it is excellent with it is the sum of good calculate it is efficient, in the sum of difference calculate inefficiency.
(3) observation method:
(1) of the invention antipruritic tincture liniment 60 are applied alone, patient clinical symptom, sign are evaluated before medication, used tricks Point-score record, it is desirable that patient's continuous medication 1 week, further consultation determined antipruritic effect after being discontinued 3 days.
(2) safety observations: record side effect deactivates the medicine when necessary.
(4) result
60 antipruritic effect observation results are referring to table 1:
1 60 antipruritic effect observations example (%) of table
Name of disease Number of cases It is excellent It is good In Difference It is total effective In vain
Cutaneous pruritus 25 20(80.3) 3(12.8) 2(6.9) 0(0) 23(93.1) 2(6.9)
Neurodermatitis 15 9(63.2) 5(33.0) 1(9.8) 0(0) 14(96.2) 1(9.8)
Chronic eczema 20 15(75.9) 3(16.9) 2(5.4) 0(1.8) 18(92.8) 2(7.2)
It is total 60 44(73.4) 11(21.7) 5(8.3) 0(0.6) 55(92) 5(8)
In conclusion antipruritic tincture liniment of the invention to three kinds with obvious pruritis skin disease (cutaneous pruritus, Neurodermatitis, chronic eczema) carry out antipruritic effect observation, clinical verification total effective rate 92%, inefficiency 8%.Complete In portion's treatment observation, the generation of no discovery toxic side effect.Clinical application shows that its effect is expelling wind and activating blood flow, skin moistening and itch stopping, it It is a kind of externally applied liniment, when use locates medicament erasing to itching, and can rub for several times day.The distinguishing feature of antipruritic tincture liniment is energy Quick itch stopping, it is nontoxic, non-stimulated, without side-effects, it is easy to use.
Each embodiment in this specification is described in a progressive manner, the highlights of each of the examples are with other The difference of embodiment, the same or similar parts in each embodiment may refer to each other.For device disclosed in embodiment For, since it is corresponded to the methods disclosed in the examples, so being described relatively simple, related place is said referring to method part It is bright.
The foregoing description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, as defined herein General Principle can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, of the invention It is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein phase one The widest scope of cause.

Claims (6)

1. a kind of antipruritic tincture liniment, which is characterized in that the component including following parts by weight: 40~50 parts of cassia bark, rheum officinale 40~ 50 parts, 30~40 parts of kuh-seng, 30~40 parts of cortex dictamni, 30~40 parts of Cortex Phellodendri, 30~40 parts of azedarach, 40~50 parts of the tuber of stemona, 30~40 parts of skin, 30~40 parts of rhizoma polygonati, 30~40 parts of pericarpium zanthoxyli, 30~40 parts of frutus cnidii, 30~40 parts of Asian puccoon, benzoic acid 0.5 ~1 part, 0.5~1 part of salicylic acid, 0.3~0.5 part of carbolic acid, thunder lock it is pungent 0.5~1 part, 0.5~1 part of camphor, menthol 0.5~ 1 part, 0.5~1 part of borneol, 3~5 parts of glycerol, 1~2 part of gentamicin, 1~2 part of lincomycinum.
2. a kind of antipruritic tincture liniment according to claim 1, which is characterized in that the component including following parts by weight: osmanthus 45 parts of skin, 45 parts of rheum officinale, 35 parts of kuh-seng, 35 parts of cortex dictamni, 35 parts of Cortex Phellodendri, 35 parts of azedarach, 45 parts of the tuber of stemona, 35 parts of the fruit of summer cypress, 30 parts of rhizoma polygonati, 32 parts of pericarpium zanthoxyli, 35 parts of frutus cnidii, 35 parts of Asian puccoon, 0.6 part of benzoic acid, 0.6 part of salicylic acid, 0.4 part of carbolic acid, thunder Trivial pungent 0.8 part, 0.6 part of camphor, 0.8 part of menthol, 0.6 part of borneol, 4 parts of glycerol, 1.6 parts of gentamicin, 1.2 parts of lincomycinum.
3. a kind of production method of antipruritic tincture liniment, which comprises the steps of:
(1) it weighs Chinese medicine: weighing the component of following parts by weight respectively: 40~50 parts of cassia bark, 40~50 parts of rheum officinale, kuh-seng 30~ 40 parts, 30~40 parts of cortex dictamni, 30~40 parts of Cortex Phellodendri, 30~40 parts of azedarach, 40~50 parts of the tuber of stemona, 30~40 parts of the fruit of summer cypress, 30~40 parts of rhizoma polygonati, 30~40 parts of pericarpium zanthoxyli, 30~40 parts of frutus cnidii, 30~40 parts of Asian puccoon, mix, obtain mixture；
(2) it first time alcoholic extraction: measures 2500mL, the alcohol that purity is 75%~95%, the alcohol is poured into volume ratio To be uniformly mixed and obtaining alcohol weak solution, and the alcohol weak solution is poured into through step (1) weighed Chinese medicine in the water of 2:1 In, sealed soak is handled 72 hours, and it is spare to obtain the first extracting solution for filtering；
(3) second of alcoholic extraction: it measures 2500mL, the alcohol that purity is 75%~95%, the alcohol is poured into volume ratio For in the water of 2:1, be uniformly mixed and obtain alcohol weak solution, and the alcohol weak solution poured into filtered through step (2) it is resulting In filter residue, sealed soak is handled 24 hours, and it is spare to obtain the second extracting solution for filtering；
(4) mixing is removed slag: the second extracting solution that step (3) obtains being added in the first extracting solution that step (2) obtains, is shaken It shakes, be uniformly mixed, filter and remove residue, it is spare；
(5) it weighs material: weighing the component of following parts by weight: 0.5~1 part of benzoic acid, 0.5~1 part of salicylic acid, coal respectively 0.3~0.5 part of acid, thunder lock pungent 0.5~1 part, 0.5~1 part of camphor, 0.5~1 part of menthol, 0.5~1 part of borneol, glycerol 3~5 Part, 1~2 part of gentamicin, 1~2 part of lincomycinum；
(6) it is resulting that the weighed benzoic acid of step (5), salicylic acid, carbolic acid and Lei Suoxin dissolution mixing: are dissolved in step (4) In mixed liquor, it is sufficiently stirred and is added glycerol dilution dissolution, extracts supernatant after standing 24 hours；
(7) sub-bottle is filling: resulting supernatant will be extracted through step (6) and be added in liquid quantitative filling machine, and according to 10~ It is filling that 30mL packing specification carries out sub-bottle.
4. a kind of production method of antipruritic tincture liniment according to claim 3, which is characterized in that step (1) weighs respectively The component of important number below: 40~50 parts of cassia bark, 40~50 parts of rheum officinale, 30~40 parts of kuh-seng, 30~40 parts of cortex dictamni, Cortex Phellodendri 30~40 parts, 30~40 parts of azedarach, 40~50 parts of the tuber of stemona, 30~40 parts of the fruit of summer cypress, 30~40 parts of rhizoma polygonati, pericarpium zanthoxyli 30~40 Part, 30~40 parts of frutus cnidii, 30~40 parts of Asian puccoon.
5. a kind of production method of antipruritic tincture liniment according to claim 3, which is characterized in that step (6) weighs respectively The component of following parts by weight: 0.5~1 part of benzoic acid, 0.5~1 part of salicylic acid, 0.3~0.5 part of carbolic acid, thunder lock pungent 0.5~ 1 part, 0.5~1 part of camphor, 0.5~1 part of menthol, 0.5~1 part of borneol, 3~5 parts of glycerol, 1~2 part of gentamicin, lincomycinum 1~2 part.
6. a kind of production method of antipruritic tincture liniment according to claim 3, which is characterized in that step (6) and step (7) Between the following steps are included: before the antipruritic tincture liniment to be used, camphor that step (5) is obtained, menthol, borneol, celebrating are big Mycin and lincomycinum are added to jointly to be extracted in resulting supernatant through step (6), is sufficiently stirred, is uniformly mixed.
CN201711079810.0A 2017-11-06 2017-11-06 A kind of antipruritic tincture liniment and preparation method thereof Pending CN109350715A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110215501A (en) * 2019-04-01 2019-09-10 曾子芸 A kind of dermatologic cream and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106606721A (en) * 2015-10-27 2017-05-03 黄明 Radix arnebiae fructus cnidii lotion used for treating pruritic diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106606721A (en) * 2015-10-27 2017-05-03 黄明 Radix arnebiae fructus cnidii lotion used for treating pruritic diseases

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110215501A (en) * 2019-04-01 2019-09-10 曾子芸 A kind of dermatologic cream and preparation method thereof

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Application publication date: 20190219