CN109331345A - A kind of optical dynamic therapy diagnostic device for capableing of optical fiber puncture - Google Patents
A kind of optical dynamic therapy diagnostic device for capableing of optical fiber puncture Download PDFInfo
- Publication number
- CN109331345A CN109331345A CN201811363983.XA CN201811363983A CN109331345A CN 109331345 A CN109331345 A CN 109331345A CN 201811363983 A CN201811363983 A CN 201811363983A CN 109331345 A CN109331345 A CN 109331345A
- Authority
- CN
- China
- Prior art keywords
- optical fiber
- metal
- syringe needle
- laser
- conehead
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6848—Needles
- A61B5/6849—Needles in combination with a needle set
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N2005/0612—Apparatus for use inside the body using probes penetrating tissue; interstitial probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Laser Surgery Devices (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The present invention relates to a kind of optical dynamic therapy diagnostic devices for capableing of optical fiber puncture, it includes optical fiber, laser, light splitting coupler and fluorescence analyser, optical fiber includes main part and piercing needle, one end of main part is connect with piercing needle, the other end is connect with light splitting coupler, and light splitting coupler is connect with laser and fluorescence analyser simultaneously so that the laser in laser can be entered by light splitting coupler in optical fiber and the fluorescence generated after sensitiser absorption laser can enter fluorescence analyser by optical fiber and light splitting coupler.The treatment diagnostic device emits photosensitizer drug absorbing wavelength laser by laser, reaches in-vivo tumour position by puncturing needle tubing through optical fiber after light splitting coupler, feux rouges kills tumour cell after the photosensitive drug in tumour absorbs.Photosensitive drug generates fluorescence after being stimulated and passes through light splitting coupler again and enter fluorescence analyser, by analysis result can analysis of fluorescence quantum yield and therapeutic effect etc., realize the effect of synchronous therapeutic and diagnosis.
Description
Technical field
The present invention relates to a kind of the field of medical instrument technology, and in particular to the optical dynamic therapy that one kind is capable of optical fiber puncture is examined
Disconnected device.
Background technique
Photodynamic therapy (Photodynamic Therapy, PDT) is to carry out medical diagnosis on disease using photodynamic effect and control
A kind of new technology treated.Its exposure basis is photodynamic effect.This is a kind of light of adjoint biological effect for having oxygen molecule to participate in
Sensitized reaction.Its process is that the laser irradiation of specific wavelength excites the photosensitizer of tissue resorption, and excitation state is photosensitive
Agent generates highly active singlet oxygen, oxygen occurs for singlet oxygen and adjacent large biological molecule again energy transmission to the oxygen of surrounding
Change reaction, generates cytotoxic effect, and then lead to cell damage or even death.Compared to traditional remedies, photodynamic therapy has
Wound is small, targeting is good, without drug resistance and the advantages of toxic side effect.But since the main wavelength of photodynamic therapy concentrates on more than 600
The red spectral band of nanometer, this wave band is big in the loss of people's body absorption, can only generally transmit several millimeters to tens of milliseconds magnitude, for
Some deep tumors can not play the role of effective optical dynamic therapy.By optical fiber, endoscope and other interventional techniques, can incite somebody to action
Laser aiming is treated to internal deep, the wound and pain caused by operation such as avoids out chest, opens abdomen.It uses and contains at present
The puncture needle of optical fiber can introduce light into vivo, but to overcome penetration Resistance, optical fiber is wrapped up by hard metal material, needle tubing
It is relatively thick, it needs to make its puncture using very big pressure in puncture process, be easy to cause biggish wound, destroy normal blood vessels group
Weave into bleeding.
Photodynamic therapy generates singlet oxygen and kills to tumour, and the fluorescent yield of singlet oxygen is to measure therapeutic effect
Important indicator.Singlet oxygen yield generally passes through the methods of remaining fluorescence in analysis blood, puncture sampling post analysis at present, can not
It realizes quick on-line checking, the accuracy of therapeutic effect and case research is influenced very big.
Summary of the invention
In view of this, being solved the object of the present invention is to provide a kind of optical dynamic therapy diagnostic device for capableing of optical fiber puncture
The deficiencies in the prior art.
The purpose of the present invention is be achieved through the following technical solutions:
A kind of optical dynamic therapy diagnostic device capableing of optical fiber and puncturing comprising optical fiber, laser, light splitting coupler and glimmering
Light analyzer, the optical fiber include main part and piercing needle, and one end of the main part is connect with piercing needle, main part
The other end is connect with light splitting coupler, and the light splitting coupler is connect with laser and fluorescence analyser so that in laser simultaneously
Laser can be entered by light splitting coupler in optical fiber and the fluorescence that is generated after sensitiser absorption laser can by optical fiber with
And light splitting coupler enters fluorescence analyser；The piercing needle includes straight type head and draws conehead, and the drawing conehead is using drawing
The taper end that the diameter that cone technique is formed is tapered；The periphery of the main part is enclosed with main body tube, outside the straight type head
It is enclosed with metal-coating, the periphery for drawing conehead is enclosed with syringe needle covering, and one end and the main body tube of the metal-coating are fixed
Connection, the other end are fixedly connected with syringe needle covering；In the syringe needle covering, the place corresponding to the taper end for drawing conehead is equipped with
Pyramidal structure that is that diameter is sequentially reduced and being wrapped in taper end periphery just.
Further, the metal-coating tight is in the periphery of the straight type head of optical fiber so that optical fiber is connected with metal-coating
It is integrated, the metal-coating is the structure that spiral helicine metal-coating or its outer surface are equipped with joint-cutting.
Further, one end that the optical fiber or main body tube are connect with light splitting coupler, which is also connected with, is able to carry out front and back vibration
Dynamic power device is so that it can give one forward pressure of optical fiber puncture needle while vibration.It is preferred that the power device
For acoustic vibration motor, the front and back Oscillation Amplitude of the power device is 10um-500um, vibration frequency 10Hz-1000Hz.
Further, the syringe needle covering is overcoat polymer or point petaloid syringe needle being made of memory metal；If poly-
Beyond the region of objective existence set is closed, then the overcoat polymer is externally provided with down dentalation or kerf structure so that when it advances when the small retrogressing of resistance
Resistance is big；If petaloid syringe needle is divided, then this point of petaloid syringe needle is made of multiple conical lobes；And when temperature is T0, by memory gold
Belong to each conical lobe divided in petaloid syringe needle constituted to be closed, this divides petaloid syringe needle in cone shape structure after closure, and closes
This point of petaloid syringe needle is wrapped in just outside the drawing conehead of optical fiber after closing；When temperature is T1, what is be made of memory metal divides valve
Each conical lobe in shape syringe needle is opened, and the drawing conehead of the optical fiber is exposed to outside and allows it to light direct irradiation to swollen
In tumor.
It is main to have the beneficial effect that the present invention provides a kind of optical dynamic therapy diagnostic device for capableing of optical fiber puncture
(1), the treatment diagnostic device emits photosensitizer drug absorbing wavelength laser by laser, by wearing after light splitting coupler through optical fiber
Pricker pipe reaches in-vivo tumour position, and feux rouges, which generates singlet oxygen after the photosensitive drug in tumour absorbs and generates to kill to tumour, to be made
With.The fluorescence that photosensitive drug generates after being stimulated is collected by optical fiber and is transmitted, then enters fluorescence analyser by light splitting coupler, is led to
Cross analysis result can analysis of fluorescence quantum yield and therapeutic effect etc., realize synchronous therapeutic and diagnosis effect.(2), for
For optical fiber punctures needle tubing, passes through the mutual synergistic effect of all parts, can be realized and passed in long blood vessel faster
Defeated purpose, as can smoothly walking nearly 2 meters of length of vessel；And can be realized higher light extraction efficiency and therapeutic effect,
There is important application value and meaning in photodynamic tumor-treatment.And the puncture needle tubing can also be applied in other necks
Domain, such as eliminate blood vessel occlusion or carry out vascular puncture.(3), the present invention is cleverly drawn by using optical fiber piercing needle
Cone technique forms the increasingly thinner drawing conehead of diameter and is conducive to illumination and photosensitizer so that effective exposure rate of light greatly promotes
Effective cooperation, the waste for reducing light or photosensitizer reduces cost to increase therapeutic effect.Importantly, passing through control
The refractive index for drawing the specification of conehead, refractive index, the angle for drawing conehead or taper end and overcoat polymer, realizes drawing conehead
On mainly go out light can emphasis expose to its front certain angle in the range of, then can dramatically increase illumination efficiency and control
Therapeutic effect, so that light, photosensitizer waste rate are less, efficient higher.(4), by forming optical fiber head using drawing cone technique
The increasingly thinner drawing conehead of diameter, and draw the cone angle of conehead to be conducive to so that effective exposure rate of light greatly promotes by control
Effective cooperation of illumination and photosensitizer, the waste for reducing light or photosensitizer reduce cost to increase therapeutic effect.Straight type head
Auxiliary irradiation can be carried out to extension position, the outer helical metal housing wrapped up is not only to the flexible of puncture needle tubing piercing needle
Property and intensity play a significant role, it is often more important that, length, spiral joint-cutting, flight or sheet metal width etc. all to light
There is extremely important adjuvant treatment effect in terms of power oncotherapy, i.e., it can also be outside metal while drawing conehead to go out light
It covers and carries out going out light on a small quantity simultaneously in joint-cutting, then assist the effective treatment for drawing conehead to realize to positions such as entire tumours.(5), cone is drawn
Head is thinner, increases its flexibility, and brittleness reduces, it is not easy to situations such as fractureing.Syringe needle covering can protect drawing conehead, make
It does not allow frangibility, while will not be polluted by the complex fluid solid etc. in blood vessel.On overcoat polymer and/or metal-coating
Fall dentalation or barb-like structure resistance is big when resistance small retrogressing when to advance, needed to effectively reduce to puncture
Thrust makes to puncture needle tubing in the blood vessel forward more smooth, reduces operating difficulty and operating time.Pawl shape in the present invention
Structure or barb-like structure etc. cooperate vibrating motor, realize effective transmission that is convenient, being not easy retrogressing of advancing, are conducive to
It smoothly walks in blood vessel.The setting of vibrating motor can make to puncture the regular generation miniature deformation of needle tubing, and the spiral shell of spiral part
Away from contraction, help to move ahead in the blood vessel, and overcoat polymer can prevent its retrogressing, therefore considerably increase laser propagation effect.
(6) even if, overcoat polymer can also make to draw conehead phenomena such as fractureing, have the protection of overcoat polymer also to damage
Blood trouble pipe etc. will not be lost in body.Point petaloid syringe needle cleverly uses the characteristic of memory metal, it is creative with it is internal
It walks temperature, fuel factor of light etc. to be combined, realize in transmission process, optical fiber head is protected, point of closure
Petaloid syringe needle can also be punctured, and it is stronger to be conducive to across blood vessel walking, practicability during walking；And it is imitated by the fever of light
It answers, so that petaloid syringe needle will be divided to open in illumination, so that the light in optical fiber is shone directly into purpose position and realize treatment etc..
Generally speaking, clinical good application effect, it is practical, there is biggish application value.
Detailed description of the invention
Fig. 1 is the overall structure diagram of optical dynamic therapy diagnostic device；
Fig. 2 is light splitting coupler structural schematic diagram；
Fig. 3 is the section structural schematic diagram that optical fiber punctures needle tubing；
Fig. 4 is the perspective structure schematic diagram that optical fiber punctures needle tubing；
Fig. 5 is the structural schematic diagram of metal-coating；
Fig. 6 is the structural schematic diagram of the optical fiber puncture needle tubing traveling process under vibrating motor driving；
Fig. 7 is another structural schematic diagram in the optical fiber puncture needle tubing traveling process under vibrating motor driving；
Fig. 8 is malformation schematic diagram of the piercing needle under the driving of vibrating motor；
Fig. 9 is the section structural schematic diagram (seeing from inside to outside) of main body tube；
Figure 10 is wound around the cross-sectional structure schematic diagram of the main body tube outside fiber body portion；
Figure 11 is the overall structure diagram that optical fiber punctures needle tubing；
Figure 12 is the diagrammatic cross-section of the piercing needle containing housing；
Figure 13 is the perspective diagram of the piercing needle containing housing；
Figure 14 is the thickness structure schematic diagram of overcoat polymer；
Figure 15 is the range schematic diagram for drawing the light emission on conehead or overcoat polymer to go out；
Figure 16 is the emergent light spot schematic diagram for drawing conehead；
Figure 17 is the schematic diagram of optical fiber puncture needle tubing when point petaloid syringe needle is closed；
Figure 18 is the structural schematic diagram of head end when point petaloid syringe needle is opened；
Figure 19 is the sectional view for the piercing needle containing housing that optical fiber punctures needle tubing
Figure 20 is the partial structure diagram of spiral helicine metal-coating；
Figure 21 is cross-sectional view when point petaloid syringe needle is closed together；
Figure 22 is cross-sectional view when point petaloid syringe needle is opened；
Figure 23 is the range schematic diagram that point petaloid syringe needle opens that the light emission on post-tensioning conehead goes out；
Figure 24 is Temperature Distribution schematic diagram when a point petaloid syringe needle has light irradiation；
Figure 25 is the structural schematic diagram of the outer surface of metal-coating；
Figure 26 is the structural schematic diagram of the outer surface of metal-coating.
In figure, straight type head -- 1, draw conehead -- 2, overcoat polymer -- 3, metal-coating -- 4, divide petaloid syringe needle -- 5, syringe needle
Covering -- 6, main part -- 8, main body tube -- 9, optical fiber punctures needle tubing -- and 10, vibrating motor -- 11, light splitting coupler -- 12, fluorescence
Analyzer -- 13, laser -- 14, taper end -- 21, pyramidal structure -- 31, dentalation -- 32, joint-cutting -- 33, cone
Shape valve -- 51, annular ring -- 52, tip -- 53, tail end -- 54, it is responsible for housing -- 106, hydrophilic coating -- 107.
Specific embodiment
The following is a clear and complete description of the technical scheme in the embodiments of the invention, it is clear that described embodiment
It is a part of the embodiment of the present invention, instead of all the embodiments.The detailed description of the embodiment of the present invention presented below is simultaneously
It is not intended to be limiting the range of claimed invention, but is merely representative of selected embodiment of the invention.Based in the present invention
Embodiment, this field commonsense method personnel every other embodiment obtained without creative efforts,
It shall fall within the protection scope of the present invention.
Embodiment 1
A kind of optical dynamic therapy diagnostic device for capableing of optical fiber puncture comprising optical fiber punctures needle tubing 10, laser 14, divides
Photo-coupler 12 and fluorescence analyser 13, it includes optical fiber that the optical fiber, which punctures needle tubing, and the optical fiber includes main part 8 and puncture needle
One end of head, the main part 8 is connect with piercing needle, and the other end of main part is connect with light splitting coupler 12, the light splitting
Coupler 12 is connect with laser 14 and fluorescence analyser 13 simultaneously so that the laser in laser 14 can be coupled by light splitting
The fluorescence generated in the entrance optical fiber of device 12 and after sensitiser absorption laser can be entered glimmering by optical fiber and light splitting coupler 12
Light analyzer 13；As shown in Figure 1.
The piercing needle includes straight type head 1 and draws conehead 2, and the front end for drawing conehead 2 or free end are to use to draw
The taper end that is tapered of diameter that cone technique is formed, one end of straight type head 1 are fixedly connected or one with 8 integrally connected of main part
Body formed, the other end is fixedly connected or is integrally formed with the larger diameter end of conehead is drawn.
The periphery of the main part 8 is enclosed with main body tube 9, and the straight type head 1 is wrapped with metal-coating 4, the metal
4 tight of housing is in the periphery of straight type head 1 so that the straight type head 1 and metal-coating 4 of optical fiber are connected as one；The drawing conehead
2 periphery is enclosed with syringe needle covering 6；One end of the metal-coating 4 is fixedly connected with syringe needle covering or integrally connected, outside metal
The other end of set is fixedly connected with main body tube or integrally connected；As shown in Figure 3；The piercing needle and the gold outside piercing needle of optical fiber
Puncture needle head end can be collectively referred to as by belonging to housing 4 and overcoat polymer 3.
In the syringe needle covering 6, corresponding to draw conehead 2 on taper end place be equipped with diameter be sequentially reduced, simultaneously
Just it is wrapped in the pyramidal structure of taper end periphery, as shown in Figure 3-4.
Preferably, the light splitting coupler 12 is made of the reflecting mirror of 50% reflectivity, laser 14 emit feux rouges by
Reflecting mirror enters the optical fiber after penetrating, and enters the fluorescence analyser after being reflected by the fluorescence that optical fiber is collected by reflecting mirror
13, as shown in Figure 2.
As further preferred embodiment, the syringe needle covering is overcoat polymer or point being made of memory metal
Petaloid syringe needle.
If overcoat polymer, then overcoat polymer 3 is transparent, in the overcoat polymer, corresponds to taper end
Place be equipped with diameter is sequentially reduced and pyramidal structure that be wrapped in taper end periphery just, the overcoat polymer peripheral hardware
There are down dentalation or kerf structure so that resistance is big when resistance small retrogressing when it advances；
If petaloid syringe needle is divided, then this point of petaloid syringe needle is made of multiple conical lobes；And when temperature is T0, by memory gold
Belong to each conical lobe divided in petaloid syringe needle constituted to be closed, this divides petaloid syringe needle in cone shape structure after closure, and closes
This point of petaloid syringe needle is wrapped in just outside the drawing conehead of optical fiber after closing；When temperature is T1, what is be made of memory metal divides valve
Each conical lobe in shape syringe needle is opened, and the drawing conehead of optical fiber is exposed to outside and allows it to light direct irradiation to tumour
On.Memory metal includes Nitinol, corronil, albronze, ormolu etc..
As further preferred embodiment, as in Figure 3-5, the metal-coating 4 is spiral helicine metal-coating,
The metal-coating 4 is to carry out laser cutting on metal tube to form the helical structure of helical form joint-cutting to make it have some strength
Increase certain flexibility simultaneously.
It is highly preferred that in metal-coating 4, as shown in figure 5, the width a of joint-cutting is 0.1-0.5mm, as 0.1mm,
0.2mm, 0.3mm, 0.4mm, 0.5mm etc., the width b for constituting the sheet metal of 4 helical structure of metal-coating is 0.2-1mm, such as
0.2mm, 0.4mm, 0.6mm, 0.8mm, 1mm etc.；The width a of joint-cutting and the data of width b of sheet metal and matching for the two
Can conjunction relationship directly affects pass through blood vessel and the smoothness across blood vessel, but also affects and pierce into from a blood vessel
Enter the piercing intensity of another blood vessel.Width a and width b it is too wide it is too narrow can all affect its flexibility and intensity, intensity is too
It is strong then can not be and very big to the injury tolerance of blood vessel by the knee of blood vessel；It is flexible too strong, then it is longer can not to pass through length
Blood vessel, the length within 1 meter is easier to, but 1 meter or more of blood vessel is difficult across and user's bad control in vitro
And direction, when penetrating into another blood vessel from a blood vessel, due to the too low also bad puncture of intensity, intensity it is too strong and
Flexible too intensity cannot achieve up in the blood vessel or organ of depth into the human body, in liver neoplasm.Only suitable width a matches
Good effect can be realized by closing the suitable width side b.
As further preferred embodiment, the optical fiber punctures one end that needle tubing is connect with light splitting coupler 12, i.e.,
It stays in external one end and is connected with the power device for being able to carry out front and back vibration so that it can wear while vibration to optical fiber
One forward pressure of pricker pipe.
The power device is preferably acoustic vibration motor 11, i.e. vibrating motor 11, and the front and back of the power device vibrates width
Degree is 10um-500um, vibration frequency 10Hz-1000Hz.
Such as: when puncturing, needle tubing will be punctured and connect acoustic vibration motor 11, vibration frequency 100Hz, Oscillation Amplitude is
50um.As shown in figs 6-8, when acoustic vibration motor 11 vibrates forward, needle tubing overall structure deformation occurs conduction vibration is punctured,
As shown in A in Fig. 6 and Fig. 8, when vibrating forward, miniature deformation occurs for puncture needle, bending and metal-coating including puncturing needle tubing
The contraction of screw pitch in 4, the elastic deformation promote needle point to travel forward, resistance are overcome to puncture forward.When vibrating backward, such as Fig. 7
With shown in the B in Fig. 8, since overcoat polymer 3 has dentalation, frictional force is much larger than and travels forward, therefore shakes in sound wave
When dynamic motor 11 vibrates backward, needle point tends to motionless and puncture needle tubing is pulled integrally to travel forward.In multiple vibration while applying
Under the action of adding extra pressure, punctures needle tubing and continue to puncture forward.Apply pressure needed for such puncture mode and is less than tradition puncture
Needle, therefore it is thinner more soft to allow optical fiber puncture needle, while can complete to puncture effect.
As further preferred embodiment, the length of the piercing needle is 7-10mm, wherein the syringe needle covering
Length L be 2.5-4mm, such as 3mm；The length l of the metal-coating 4 or straight type head 1 is 4.5-6mm, such as 5mm, such as Fig. 3 institute
Show.Syringe needle covering 3 draws the length of conehead 2 is too long to be easy to cause to damage to blood vessel, and is unfavorable at blood vessel slight curves
Walking, it is too short to cannot achieve puncture effect, and row in smooth, quick blood vessel can not be carried out under the cooperation of vibrating motor 11
It walks.Metal-coating 4 is too long or too short be also unfavorable for walking or cannot achieve in blood vessel good auxiliary conehead 2 is drawn to pierce through blood vessel
The operation such as wall, it is often more important that, certain light can be projected in the spiral joint-cutting of metal-coating 4, then adjuvant treatment can be achieved, thus it is golden
Joint-cutting and width, the length of metal-coating 4 of sheet metal etc. for belonging to housing 4 play a significant role therapeutic effect.Therefore, only
Have in the case where appropriate length, blood vessel can be passed through well, and complete the operations such as good transmission, piercing, for puncturing
Needle tubing has synergistic effect.
As further preferred embodiment, the length of the main body tube 9 is 1-2m, such as 1.8m, fiber body portion 8 with
The length of main body tube 9 is consistent, and 8 tight of main body tube is outer in the main part 8 of optical fiber so that the two is integrally formed, and facilitates transmission.
The diameter of the main part 8 of optical fiber and straight type head 1 can be 400 μm, can be silica fibre, in the drawings conehead, bore
The most advanced diameter of shape tail end is 10-50 μm, such as 20 μm, 30 μm, 40 μm, which will increase the flexibility of optical fiber instead,
Reduce its brittleness；The outer diameter of the metal-coating 4 and main body tube 9 can be 600 μm, and internal diameter can be 400 μm.
Preferably, draw the refractive index of conehead 2 for 1.45-1.55, preferably 1.5, then drawing the cone angle beta of conehead 2 is 7-25 °,
As shown in Figure 14 and 19, then can guarantee to draw the light that goes out of conehead substantially is to emit light within the scope of 60-120 °, angle such as Figure 23
In α shown in, angle is as shown in the α in Figure 15 and 23.Specifically, by optical analog it is found that cone angle beta is 22 °, then light
Angle of divergence alpha is within 120 °, if cone angle beta is 7.6 °, the angle of divergence alpha of light is within 60 °.Therefore, when the cone angle beta for drawing conehead 2
When being 7-25 °, draw light on conehead can effective directive destination locations then can be effective in such as tumour containing photosensitizer
Using luminous energy, light emission rate is greatly increased.If puncture covering is overcoat polymer 3, the refractive index of overcoat polymer 3 can be
1.45-1.55, such as 1.45,1.5,1.55, the light for drawing conehead is effectively shot out from overcoat polymer 3.
The refractive index of the main part of optical fiber is also 1.5, however, being coated with covering outside main part 8, the refractive index of covering is lower than
Optical fibre refractivity, such as can be 1.2,1.3, so that the light in the main part 8 of optical fiber will not be projected from main part, light is constrained,
Expose to light then can only again on the tumor locus containing photosensitizer from drawing conehead to issue.
It is preferred that not having outside the straight type head 1 of the optical fiber at spiral helicine metal-coating 4, i.e. optical fiber at the joint-cutting of metal-coating 4
The refractive index type head 1 more straight than optical fiber for wrapping up covering or covering is smaller, then at the joint-cutting that the light of a part can be passed through spiral sleeve
Light is carried out out, realizes the irradiation to other auxiliary positions, then effectively to be irradiated by drawing conehead to attack keypoint part directly, directly
Type head 1 carries out auxiliary irradiation to extension position, realizes effective irradiation to whole position to be illuminated, as irradiation contains photosensitizer
Tumor tissues, can effectively increase photosensitizer drug effect performance, finally increase therapeutic effect.
In the present embodiment, the restraining force of 3 pairs of light of overcoat polymer is poor, and refractive index 1.2-1.5 then draws conehead to come out
Light can pass through overcoat polymer 3 project.In use, the piercing needle one end for puncturing needle tubing is pierced into blood vessel first, so
It transmits in the blood vessel afterwards, the external one end for puncturing needle tubing can connect vibrating motor 11, and puncture needle tubing is assisted to reach pre- by blood vessel
Determine position, such as intracorporal tumour (such as liver neoplasm) is medium.Then open laser 14, by the feux rouges of 650nm (wavelength it is red
Light can make photosensitizer react realize treatment tumour purpose) by light splitting coupler 12 enter optical fiber in, then from optical fiber
Drawing conehead project, and expose to the tumor locus containing photosensitizer, the feux rouges of 650nm through photosensitizer drug (such as
PHOTOFRINR singlet oxygen is generated after) absorbing to kill tumour cell.And photosensitizer drug generates fluorescence after absorbing feux rouges,
The fluorescence that optical fiber puncture needle is collected enters back into fluorimetric assay for biological materials instrument 13 (such as by monochromator and Gao Ling by light splitting coupler 12
Quick detector composition), by analysis of fluorescence intensity, singlet oxygen yield is analyzed.By apparatus above, realize in light power
It treats while carrying out online fluorescence analysis, improve the speed and accuracy rate of analysis.
Embodiment 2
On the basis of embodiment 1, the main body tube 9 is the helix tube containing multiple spiral coils, and the joint-cutting of helix tube is
The helical structure of helical form joint-cutting is formed using laser cutting.
As shown in figure 9, based on the Fig. 9 pipe 9 section schematic diagram, and be the view seen from inside to outside from main body tube 9；It is described
In main body tube 9, the width a of joint-cutting is 0.02-0.2mm, such as 0.05,0.08mm, 0.1mm, 0.15mm, is constituted in main body tube 9
The width d of the flight of helical structure is 0.5-3mm, such as 1mm, with a thickness of 0.05-0.1mm, such as 0.08mm.The length of main body tube 9
Nearly 2 meters of degree, penetrating human body usually just has 1-1.8m, and human vas thickness is different, there are also certain curvature, so long
Distance, such special vascular environment, it is very high to its intensity and flexibility requirements, therefore the width of the width a of joint-cutting, flight
Can the data and matching relationship of d and its thickness directly affect pass through blood vessel and the smoothness across blood vessel, even
Have an effect on the intensity that piercing needle is pierced into tumor vessel wall.The too wide of width a and width d too narrow can all affect its flexibility
And intensity, only suitable width a cooperate the suitable width side d that can realize good effect.
The main body tube 9 is biomedical metallic material, and including but not limited to stainless steel, synthetic fibers, carbon fiber, titanium close
One of gold, Jin Heyin, preferably stainless steel, see on the whole, which wrapped up simultaneously by a stainless steel wire in fact
It is helically wound around the wrapping wire layer of 8 periphery of main part of optical fiber, can also be two or more wrapping wire windings certainly.
As shown in figs. 9-10, the main body tube 9 is externally provided with supervisor's housing 106 to increase the leakproofness and reduction of main body tube 9
Resistance；The material for being responsible for housing 106 can be polyamide or polypropylene etc., and other many polymer are ok.Outside the supervisor
The outside of set 106 is coated with hydrophilic coating 107 to increase blood compatibility.The hydrophilic coating 107 is using chemically stable
Material is made, including but not limited to polytetrafluoroethylene (PTFE), silicon rubber, polyethylene, polyvinyl chloride, fluorocarbon polymer and polyurethane.It applies
Hydrophilic coating is covered, resistance in the blood vessel is reduced, the long blood vessel of interior environment complexity can be passed through.
Hydrophobic coating substitution can be used in hydrophilic coating 107 in the present embodiment.
Embodiment 3
On the basis of embodiment 1 or 2, as shown in figures 17 to 20, the sheet metal for constituting 4 helical structure of metal-coating is to fall
Hook formation, such structure have very little resistance when advancing, and when retreating, resistance is larger, so as to apply weak impact
Mode is punctured in a manner of progressive, effectively reduces the pressure for puncturing and needing.
Barb-like structure are as follows: the sheet metal 41 for constituting metal-coating 4 is less than the thickness of rear end in the thickness of front end, so that light
Fine puncture needle more easily walks forward and is not easy to retreat.
It is highly preferred that as shown in figure 20, since the thickness c of sheet metal front end is too thin, being not easy to indicate its thickness in the accompanying drawings
Degree, therefore the position of c is only denoted in attached drawing, do not provide its thickness relationship.In falling in dentalation for metal-coating 4, i.e. structure
In structure of the thickness less than the thickness of rear end at the front end of the sheet metal of metal-coating, the thickness c of sheet metal front end is 50-70
μm, the thickness d of sheet metal rear end is 90-110 μm, and the thickness difference of front-end and back-end is 30-50 μm.The control of the thickness for
Effectively smoothly transmission is advanced important, and thickness difference is too big then or to be will increase metal-coating outer diameter or need to reduce gold
The internal diameter for belonging to housing, then be affected to integrated piercing needle tubing, and thickness difference is big, the thickness of sheet metal trailing flank increase compared with
Greatly, it will increase whole advance resistance instead, and for minute blood vessel, also will increase the degree of injury to blood vessel.
If if thickness difference is too small, not having helps to advance, prevents that falls back most to use.
Embodiment 4
In embodiment 1-3 any one on the basis of, as illustrated in figs. 11-14, if the syringe needle covering be polymer outside
Set, then in the overcoat polymer 3, the outside of the taper end 21 corresponding to optical fiber is equipped with the taper knot that diameter is sequentially reduced
Structure 31, then it is consistent with 21 structure of taper end of conehead 2 is drawn.
The material of the overcoat polymer 3 can be polyamide or polypropylene.Overcoat polymer 3 be externally provided with down dentalation or
Kerf structure, as illustrated in figs. 11-14, such structure have very little resistance when advancing, and when retreating, resistance is larger, so as to
It is enough to apply in a manner of weak impact, punctured in a manner of progressive, effectively reduce the pressure for puncturing and needing.
As further preferred embodiment, the dentalation 32 that falls outside the overcoat polymer 3 is by multiple front ends
The big truncated cone-shaped structure of the small rear end diameter of diameter is constituted, and as shown in figure 11, i.e., multiple truncated cone-shaped structures are end to end to be looped around drawing
The periphery of conehead, so that optical fiber punctures needle tubing and more easily walks forward and be not easy to retreat.
Specifically, as shown in figure 5, being fallen in dentalation 32 at this, the nose thickness c of truncated cone-shaped structure is 50-70 μm, circle
The thickness d of the rear end of platform shape structure is 90-110 μm, and the thickness difference of front-end and back-end is 30-50 μm.The control pair of the thickness
In effectively smoothly transmission is advanced important, thickness difference is too big then or to be will increase metal-coating outer diameter or needs to reduce
The internal diameter of metal-coating is then affected to integrated piercing needle tubing, and thickness difference is big, the diameter in truncated cone-shaped structure back side face
Increase larger, will increase whole advance resistance instead, and for minute blood vessel, also will increase the damage to blood vessel
Degree.If if thickness difference is too small, not having helps to advance, prevents that falls back most to use；Therefore, above-mentioned dentalation 32
Thickness and truncated cone-shaped structure rear and front end needle tubing is punctured for optical fiber the entirety such as thickness difference move ahead it is extremely important.
In the present embodiment, if a length of 650nm of input optical fibre light wave, when input power is 1W, conehead is drawn to go out from optical fiber
Penetrating optical power is 0.94W, and emergent power is very high, and the angle of divergence is about 60 degree, can effectively be irradiated for keypoint part
Or treatment；Light spot shape is as shown in figure 16.
Embodiment 5
On the basis of embodiment 3, as in figs. 17-19, if the syringe needle covering be made of memory metal divide valve
Shape syringe needle 5, then point petaloid syringe needle illumination effect under heating generate deformation and opening appears the light of optical fiber；The metal-coating
4 are fixedly connected with point tail end of petaloid syringe needle 5 or larger diameter end, and described point of petaloid syringe needle 5 is made of multiple conical lobes 51, such as scheme
Shown in 19.
When temperature is T0, as shown in figure 17, each conical lobe 51 in point petaloid syringe needle 5 being made of memory metal is closed
It closes, this divides petaloid syringe needle 5 to be in cone shape structure after closure, and this point of petaloid syringe needle 5 is wrapped in optical fiber just after closure
Drawing conehead 2 outside；Optical fiber is wrapped in point valvular structure, protects optical fiber, and during walking in the blood vessels, circular cone figure
Divide valvular structure is convenient to walk in the blood vessel, advance resistance is small, and backing resistance is big, convenient to move ahead.
When temperature is T1, as depicted in figs. 18-19, each conical lobe in point petaloid syringe needle 5 being made of memory metal
51 open, then the drawing conehead 2 of the optical fiber is exposed to outside allow it to will be on light direct irradiation to tumour.
As further preferred embodiment, when being emitted in optical fiber without light, i.e., when laser 14 is not turned on,
The temperature of point petaloid syringe needle transmitted in vivo is T0, and each conical lobe in point petaloid syringe needle closes up for needle-shaped or cone shape；
When optical fiber has light outgoing, i.e., the laser 14 that is connect with optical fiber opening make optical transport to optical fiber after, due to the fuel factor of optical fiber,
I.e. when light is emitted by conical fiber and is radiated on memory metal so that point petaloid syringe needle 5 being made of memory metal by
Temperature gradually rises as T1 after illumination, then each conical lobe divided in petaloid syringe needle is opened, that is, is more than its phase transition temperature and generates
Outside prefabricated deformation is in open shape；Light is emitted by opening, i.e., the exposed light made on optical fiber of drawing conehead of optical fiber is directly from beating
Point petaloid syringe needle opened projects.
Temperature T0 can be 37 DEG C, and temperature T1 can be 50 DEG C；Such as: at temperature T0 (such as 37 DEG C), petaloid syringe needle 5 will be divided
Be made as in advance it is close-shaped, temperature be T1 (such as 50 DEG C) when, point petaloid syringe needle 5 in advance is made as open shape.Then puncture in vivo
When, light passing, head do not divide 5 temperature of petaloid syringe needle to be body temperature T0 (37 DEG C) in optical fiber, and point closure of petaloid syringe needle 5 realizes that transmission is worn
Thorn.Leading to 100mW wavelength after being punctured to the predetermined area, in optical fiber is 650nm laser, draws conehead to be radiated by remembering by optical fiber
What metal was constituted divides on petaloid syringe needle 5；As shown in figure 24, Figure 24 is that have 500W/ (m2.K) right in the outside on puncture needle head
Conductance enthusiasm condition (the typical rate of heat dissipation of liquid convection), temperature can be increased to 70.5 DEG C under 100mW laser action, more than T1 temperature
It spends (50 DEG C), generates deformation and open.
As further preferred embodiment, the conical lobe 51 be thereon each equal curvature of point it is consistent, by arc
The conical lobe that face is constituted.The shapes and sizes of all conical lobes 51 are consistent, then the power being distributed on each conical lobe 51 is more
Uniformly, whole dynamics is bigger.Divide and contains 2-5 conical lobe, preferably 2 or 3 conical lobes in valvular structure；Valve number is then every too much
A conical lobe is too small, and intensity is inadequate.
Preferably, divide petaloid syringe needle 5 or conical lobe 51 with a thickness of 0.06-0.12mm.When its closure, wrap up just
In the outside for drawing conehead 2, preferably draws conehead 2 and divide seamless between petaloid syringe needle, then draw conehead 2 for a point petaloid syringe needle 5
Have the function of that auxiliary enhances its intensity, then cooperate the conical lobe 51 of specific thicknesses, is conducive to puncture the transmission of needle tubing, be pierced into
Deng with synergistic effect.
Preferably, dividing petaloid syringe needle 5 includes tail end 54 and tip 53, and as shown in figs. 17-18, the conical lobe 51 is by tail
To tip, its width is sequentially reduced at end, and when each conical lobe 51 closure, the diameter of tail end 54 is greater than the diameter at tip 53；Respectively
The tail end integrally connected of a conical lobe forms the annular ring 52 of cirque structure, the annular ring 52 and the fixed company of metal-coating 4
It connects.
Preferably, when each conical lobe 51 is closed, close to each other two side in two neighboring conical lobe 51 is tight
Close closing, this divides valvular structure to constitute totally enclosed cone shape structure, preferably protects the drawing conehead of optical fiber, and conehead is drawn to exist
It is contaminated in transmission process, influencing the later period goes out the exposure rate of light, to will affect the effect of photosensitizer on tumor locus.
Embodiment 6
On the basis of embodiment 5, as shown in fig. 21-22, in conical lobe 51, for the closing of adjacent conical valve or point
The side opened is inclined-plane 105, i.e. there are two sides for a conical lobe 51, and each side is bevel structure.And all conical lobes
105 direction of inclined-plane in 51 is consistent, i.e., consistent by direction clockwise or counterclockwise, then ensures in two neighboring conical lobe
Two inclined-planes of mutual closing can be just to being combined, i.e., one is gradually to tilt from the inside, and one is from outside
Slope inwardly, then the two can be combined together just, so that being smooth arc to its rear the inner surface and the outer surface is combined
Shape face.
It is designed as bevel structure, the width for being equivalent to side broadens, then makes mutual closing in two neighboring conical lobe 51
When contact area increase, then divide petaloid syringe needle 5 be closed after, the bond strength between each conical lobe 51 is bigger, is showed
The puncture effect of acicular texture out is more preferable.Importantly, since side is designed as inclined-plane 105, so that two neighboring cone
Contact width when shape 51 mutual closing of valve increases, better tightness, therefore in the blood vessel in transmission process, it is not easy to make inside
Optical fiber draws conehead 2 to be disseminated, to influence final light out.
The attached drawing of the present embodiment be by taking 4 valve conical lobes 51 as an example, in fact, 2 valves, 3 valves.
Embodiment 7
On the basis of embodiment 5 or 6, in conical lobe 51, with 51 closing of adjacent conical valve or the side separated or tiltedly
Face 105 is equipped with the first flexible layer so that the bonding strength more high leakproofness between conical lobe 51 is more preferable, and better tightness can
Conehead is drawn in liquid pollution in better anti-hemostatic tube etc., and better tightness also can help to improve point petaloid syringe needle of closure
Intensity.
As further preferred embodiment, the medial surface at the tip of the conical lobe is equipped with the second flexible layer so as to divide
It is higher by resultant force intensity between conical lobe when valvular structure is closed, better tightness.
The thickness of first flexible layer and the second flexible layer can be 0.005-0.04mm, the first flexible layer and the second flexible layer
Material can be polytetrafluoroethylene (PTFE), polyamide or polypropylene etc..
Embodiment 8
On the basis of any one in embodiment 1-7, overcoat polymer 3 or its outer surface are equipped with multiple joint-cuttings
33 structure falls joint-cutting 33 in the outer surface of metal tube laser cutting wedge shape as shown by figures 25-26, i.e. joint-cutting 33
Inclined direction is to tilt backwards, and as shown in figure 25, the width of joint-cutting 33 is by lateral surface one end to close to medial surface one end,
Thickness successively reduces.Preferably, the overcoat polymer 3 in the present embodiment can be for by tail end to front end, i.e. its diameter from back to front
The structure being sequentially reduced facilitates advance, as shown by figures 25-26.
Resistance is big when resistance small retrogressing when kerf structure to advance, so that the thrust for puncturing and needing is effectively reduced,
Make to puncture needle tubing in the blood vessel forward more smooth, reduces operating difficulty and operating time.
It should also be noted that, the barb-like structure on metal-coating described in embodiment 5 may be such as this implementation
Kerf structure described in.
Embodiment 9
A kind of application of optical dynamic therapy diagnostic device that capableing of optical fiber puncture, which punctures needle tubing can be in long blood vessel
It smoothly walks, and vascular wall or obturator can effectively be punctured, moreover it is possible to the blood vessel, tissue or organ etc. of human body depths
The irradiation of light is carried out, therefore the puncture needle tubing can effectively be applied in light power oncology, additionally it is possible in dredging vascellum internal resistance
Plug thing, which is applied and has extravasated blood or clot in the tissue etc., is dredged or is treated.Importantly, by will be intracorporal
Light leads in fluorescence analyser 13 and is analyzed, and can also be achieved the treatment diagnostic effect to corresponding disease.
It, will if interventional therapy is liver neoplasm if the optical fiber, which punctures needle tubing, to be used in photodynamic tumor-treatment
Optical fiber punctures needle tubing and is pierced into femoral artery, then can enter liver artery under the cooperation of vibrating motor 11, then from femoral artery puncture,
Blood vessel in liver neoplasm is finally entered, laser 14 is opened, the feux rouges that laser 14 issues enters by light splitting coupler 12
In optical fiber, light is reached by optical fiber on the drawing conehead of optical fiber most end, and then light is radiated at the tumour tumor for having injected photosensitive drug
(if overcoat polymer, then light is directly projected from overcoat polymer body；If petaloid syringe needle is divided, then petaloid syringe needle is divided to open,
Light is directly projected from drawing conehead), make the intracorporal photosensitive drug of tumor that photochemical reaction generation singlet oxygen occur and then causes tumour tumor
The necrosis of body and apoptosis, to achieve the purpose that treat tumour.And the fluorescence that photosensitive drug generates after being stimulated is by piercing needle
It collects, fluorescence analyser 13 is entered by optical splitter, passes through the interpretation of result fluorescence quantum yield of fluorescence analyser 13 and treatment
Effect etc..
Embodiment 10
In order to further study the practical function that the optical fiber in the present invention punctures needle tubing, the applicant is from the blood vessel passed through
Multiple latitudes such as type and length, crossing time, the dynamics at tip, radiation response, therapeutic efficiency and piercing precision carry out
Research.
Method: enter for liver neoplasm sampling biopsy: by Seldinger arteriopuncture technology, in irradiation image
Under guidance, optical fiber is punctured into needle tubing and is pierced into femoral artery, under the booster action of vibrating motor 11, enters liver via femoral artery
Artery, then enter liver vessel from liver artery, eventually enter into inside tumor blood vessel；To joined the tumor tissues of photosensitizer into
Row irradiation, treatment.
The length of vessel passed through: 1.6 meters.
Puncture needle tubing in embodiment 2,4,5 and 7 is tested as experimental group 1-4.
Comparative example 1: non-polymer housing, it is other consistent with embodiment 4.Comparative example 2: without conehead is drawn, needle-less covering is worn
The structure of pricker pipe front end is the structure for the straight type head 1 that metal-coating 4 wraps up, other consistent with embodiment 2.Comparative example
3: without spiral helicine metal-coating 4, i.e. drawing conehead is directly ined succession main part 8, other consistent with embodiment 2.Comparative example 4: will
Main body tube in embodiment 2 becomes spring.Comparative example 5: the metal-coating 4 in embodiment 2 is become into spring.Comparative example 6: nothing point
Petaloid syringe needle draws conehead exposed, other consistent with embodiment 5.
For being summarized as follows shown in table for the above test group.
In upper table, 1) it reaches before the tumor vascular time refers to tumor vessel, required for walking in the blood vessel
Time.2) light extraction efficiency of optical fiber refers to that the piercing needle of the light actually exposed on tumour photosensitizer and optical fiber is shone as normal
It is incident upon the percentage of the light on photosensitizer.3) the effective illumination on the photosensitizer for exposing to tumour that the illumination efficiency of optical fiber refers to
Amount, it is proportional with absorption efficiency of the photosensitizer to light；4) it when tip dynamics refers to being pierced into tumor vessel inner wall when being pierced into, wears
Power possessed by spike head.
The result of above-mentioned experimental group and contrast groups is described as follows shown:
Experimental group 1-4: intravascular walking is easy, light emission rate, the illumination efficiency of optical fiber, puncture effect and therapeutic effect etc.
It is relatively good.
Comparative example 1: due to non-polymer housing, also without dentalation, therefore the time walked in the blood vessel can increase
Add, and due to drawing conehead exposed, with certain brittleness, therefore needs carefully, also to will affect thetravel times in the blood vessel when walking.
Due to drawing conehead exposed, in transmission process, intravascular environment, which has it, to be had a certain impact, and in the process of walking,
On the also refractive index for influencing light and light emission rate easy to attach substance, therefore cause it in the light extraction efficiency of the optical fiber of destination locations
It is lower.Since its light extraction efficiency is lower, therefore the illumination efficiency of its optical fiber is leveraged, that is, exposes to effective light on photosensitizer
It reduces.Its tip dynamics when piercing through is substantially reduced.
Comparative example 2: it will affect its walking in the process of walking due to that can not puncture, because some are needed across blood
The place that tube wall is walked in another blood vessel is needed to be cooperated using other way, therefore largely effects on its total time walked.
Whole light extraction efficiency is lower.And light only goes out light from the joint-cutting of optical fiber top face and spiral sleeve, leads to its quantity of illumination
It substantially reduces, equally exists more blindness, prevent the light issued is from being utilized effectively, therefore the illumination efficiency of optical fiber
It is low, leverage its therapeutic efficiency.It cannot achieve puncture due to no cutting-edge structure.
Comparative example 3: the metal-coating 4 without helical structure, light is only from drawing conehead to project, then the universal face of its irradiation is small,
It is only capable of exposing to certain key regions, for other auxiliary places almost without illumination, then leverages its whole irradiation effect
Rate, to leverage its therapeutic efficiency.And certain influence is also had on tip dynamics and travel time etc..
Comparative example 4: the bad control of spring and direction, therefore leverage the total time walked.Since dynamics is bad
Control, therefore the puncture effect dynamics of certain point is substantially reduced.
Comparative example 5: if selection intensity and the consistent spring of the intensity of metal-coating, flexibility, elasticity etc. and this hair
Bright metal-coating is had any different, and the bad control in its direction, and the dynamics for causing its whole tip to show is less than experimental group.
Comparative example 6: it due to drawing conehead exposed, with certain brittleness, therefore needs carefully, to influence to walk when walking.Due to
Draw conehead exposed, in transmission process, intravascular environment, which has it, to be had a certain impact, and in the process of walking, thereon
It is easy to attach influence light refractive index and light emission rate substance, therefore cause its optical fiber of destination locations light extraction efficiency compared with
It is low.Since its light extraction efficiency is lower, therefore the illumination efficiency of its optical fiber is leveraged, that is, exposes to effective light drop on photosensitizer
It is low.Its tip dynamics when piercing through is substantially reduced.
Embodiment 11
Tumor rat model is established, the rat for taking tumor size almost the same only adds photosensitive as experimental subjects, control group
Agent is treated, and experimental group adds photosensitizer and carries out illumination using method of the present invention.
Experimental group 1-3 is respectively to use optical fiber described in embodiment 2,4 and 5 to puncture needle tubing to be irradiated feux rouges.Comparison
Group 1-3 is the contrast groups 1-3 in embodiment 10, and laser irradiating method is consistent with experimental group.
Method: after treatment 10 days, dissecting rat, and do coronal incision by the surface seeding point of puncture of rat, by vertical and
Horizontal direction measures tumor size, gross tumor volume=a2Π/6 b (a is the minor axis of tumour, and b is the major diameter of tumour).Tumour growth
Inhibiting rate=[(control group tumor average volume-experimental group tumor average volume/control group tumor average volume) × 100%
To indicate.Then the inhibiting rate of resulting tumour growth is as shown in the table.
Therefore, in photodynamic tumor-treatment, the efficiency of light extraction efficiency and illumination has final therapeutic effect straight
Connect influence.The therapeutic effect of experimental group of the invention is apparently higher than the effect in contrast groups.
In the present invention, light splitting coupler is 50:50 (R:T) plate beamsplitter mirror, buys producer: Thorlabs, certainly,
That buys other companies can also be with.
The above is only preferred embodiments, are not intended to restrict the invention, and to those skilled in the art, the present invention can
To there is various modifications and changes.All any modification, equivalent replacement, improvement and so within the spirit and principles of the present invention,
It is all included in the scope of protection of the present invention.
Claims (10)
1. the optical dynamic therapy diagnostic device that one kind is capable of optical fiber puncture, it is characterised in that: it includes optical fiber, laser, light splitting
Coupler and fluorescence analyser, the optical fiber include main part and piercing needle, and one end of the main part and piercing needle connect
It connects, the other end of main part is connect with light splitting coupler, and the light splitting coupler is connect with laser and fluorescence analyser simultaneously
So that the fluorescence energy that the laser in laser can be entered in optical fiber by light splitting coupler and be generated after sensitiser absorption laser
Fluorescence analyser is enough entered by optical fiber and light splitting coupler；
The piercing needle includes straight type head and draws conehead, and the drawing conehead is to be tapered using the diameter for drawing cone technique to be formed
Taper end；The periphery of the main part is enclosed with main body tube, and the straight type head is wrapped with metal-coating, the drawing conehead
Periphery be enclosed with syringe needle covering, one end of the metal-coating is fixedly connected with main body tube, and the other end is fixed with syringe needle covering
Connection；
In the syringe needle covering, corresponding to draw conehead taper end place be equipped with diameter be sequentially reduced and can be lucky
It is wrapped in the pyramidal structure of taper end periphery.
2. the optical dynamic therapy diagnostic device according to claim 1 for capableing of optical fiber puncture, it is characterised in that: the metal
For housing tight in the periphery of the straight type head of optical fiber so that optical fiber and metal-coating are connected as one, the metal-coating is spiral
The metal-coating of shape or its outer surface are equipped with the structure of joint-cutting, and if spiral helicine metal-coating, then metal-coating is in gold
Belong to and carries out being cut by laser the helical structure for forming helical form joint-cutting on pipe to make it have some strength while increase centainly soft
Toughness.
3. the optical dynamic therapy diagnostic device according to claim 1 or 2 for capableing of optical fiber puncture, it is characterised in that: described
One end that optical fiber or main body tube are connect with light splitting coupler be also connected be able to carry out front and back vibrate power device so that its
One forward pressure of optical fiber puncture needle can be given while vibration.
4. the optical dynamic therapy diagnostic device according to claim 3 for capableing of optical fiber puncture, it is characterised in that: the power
Device is acoustic vibration motor, and the front and back Oscillation Amplitude of the power device is 10um-500um, vibration frequency 10Hz-
1000Hz。
5. the optical dynamic therapy diagnostic device according to claim 3 for capableing of optical fiber puncture, it is characterised in that: the syringe needle
Covering is overcoat polymer or point petaloid syringe needle being made of memory metal；
If overcoat polymer, then in the overcoat polymer, the place corresponding to taper end is equipped with what diameter was sequentially reduced
And it is wrapped in the pyramidal structure of taper end periphery just, the overcoat polymer is externally provided with down dentalation or kerf structure
So that resistance is big when resistance small retrogressing when it advances；
If petaloid syringe needle is divided, then this point of petaloid syringe needle is made of multiple conical lobes；And when temperature is T0, by memory metal structure
At each conical lobe divided in petaloid syringe needle be closed, this divides petaloid syringe needle in cone shape structure after closure, and be closed with
This point of petaloid syringe needle is wrapped in just outside the drawing conehead of optical fiber afterwards；When temperature is T1, point petaloid needle that is made of memory metal
Each conical lobe in head is opened, and the drawing conehead of the optical fiber is exposed to outside and allows it to light direct irradiation to tumour
On.
6. the optical dynamic therapy diagnostic device according to claim 5 for capableing of optical fiber puncture, it is characterised in that: the optical fiber
Main part outside be coated with the main body wrap for preventing the light in optical fiber from projecting from side；The cone angle beta for drawing conehead is 7-
25°；The refractive index for drawing conehead is 1.45-1.55,
If syringe needle covering is overcoat polymer, the refractive index of overcoat polymer is 1.4-1.55；
The refractive index of the straight type head of optical fiber at the joint-cutting of metal-coating is 1.4-1.55 so that the light of a part passes through spiral sleeve
Joint-cutting at carry out out light；
In the drawing conehead, the most advanced diameter of taper end is 10-50 μm.
7. the optical dynamic therapy diagnostic device according to claim 5 for capableing of optical fiber puncture, it is characterised in that: the polymerization
The dentalation that falls outside beyond the region of objective existence set is to be made of the big truncated cone-shaped structure of the small rear end diameter of multiple point diameters so that optical fiber punctures
Needle tubing more easily walks forward and is not easy to retreat；
The kerf structure that falls outside the overcoat polymer is to be cut by laser to form the wedge-shaped joint-cutting that falls in the outer surface of metal tube,
The inclined direction of joint-cutting is to tilt backwards, and the width of joint-cutting is successively to be reduced by lateral surface one end to close to medial surface one end.
8. the optical dynamic therapy diagnostic device according to claim 7 for capableing of optical fiber puncture, it is characterised in that: the polymerization
Falling in dentalation outside beyond the region of objective existence set, the nose thickness of truncated cone-shaped structure is 50-70 μm, the rear end of truncated cone-shaped structure with a thickness of
90-110 μm, and the thickness difference of front-end and back-end is 30-50 μm；
Conical lobe in described point of petaloid syringe needle is that each equal curvature of point is consistent thereon, the conical lobe that is made of arcwall face；Institute
There are the shapes and sizes of the conical lobe consistent；
Temperature T0 is 37 DEG C, and temperature T1 is 50 DEG C；Be made as in advance in temperature T0 time-division petaloid syringe needle it is close-shaped, temperature be T1
When, each conical lobe in point petaloid syringe needle is made as opening shape in advance；When puncturing, not light passing in optical fiber divides petaloid syringe needle temperature
Degree is T0, and closure realizes that transmission punctures；After being punctured to the predetermined area, laser is led in optical fiber, optical fiber draws the light radiation on conehead
Onto memory metal, temperature is increased to T1 or more, and petaloid syringe needle is divided to open.
9. the optical dynamic therapy diagnostic device according to claim 2 for capableing of optical fiber puncture, it is characterised in that: in helical form
Metal-coating in, constitute metal-coating sheet metal be front end thickness be less than rear end thickness barb-like structure so that light
Fine puncture needle more easily walks forward and is not easy to retreat.
10. capableing of the optical dynamic therapy diagnostic device of optical fiber puncture according to claim 2 or 9, it is characterised in that: described
Main body tube is the helix tube containing multiple spiral coils, and the joint-cutting of helix tube is the spiral that helical form joint-cutting is formed using laser cutting
Structure；The length of main body tube is 1-2m；
The length of the piercing needle is 7-10mm, wherein the length of the syringe needle covering is 2.5-4mm；The metal-coating
Length be 4.5-6mm；
In metal-coating, the width of joint-cutting is 0.1-0.5mm, and the width for constituting the sheet metal of metal-coating helical structure is
0.2-1mm；
In main body tube, the width of joint-cutting is 0.02-0.2mm, and the width for the flight for constituting helical structure in main body tube is
0.5-3mm, main body tube with a thickness of 0.05-0.1mm.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810844992 | 2018-07-27 | ||
| CN2018108449924 | 2018-07-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109331345A true CN109331345A (en) | 2019-02-15 |
| CN109331345B CN109331345B (en) | 2019-11-15 |
Family
ID=65315983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811363983.XA Active CN109331345B (en) | 2018-07-27 | 2018-11-16 | A kind of optical dynamic therapy diagnostic device for capableing of optical fiber puncture |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109331345B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114377303A (en) * | 2022-03-23 | 2022-04-22 | 杭州高瓴医疗科技有限公司 | Flexible needle-shaped high-energy infrared water filtering therapeutic instrument |
| WO2023012406A1 (en) * | 2021-08-03 | 2023-02-09 | Modulight Corporation | Theranostic laser system |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005082254A2 (en) * | 2004-02-23 | 2005-09-09 | Ethicon, Inc. | Diagnostic swab and biopsy punch systems, and diagnostic caps for use in such systems |
| CN101269257A (en) * | 2007-03-20 | 2008-09-24 | 深圳市微创医学科技有限公司 | Optical power therapentic equipment |
| WO2017070702A1 (en) * | 2015-10-23 | 2017-04-27 | Inari Medical, Inc. | Intravascular treatment of vascular occlusion and associated devices, systems, and methods |
-
2018
- 2018-11-16 CN CN201811363983.XA patent/CN109331345B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005082254A2 (en) * | 2004-02-23 | 2005-09-09 | Ethicon, Inc. | Diagnostic swab and biopsy punch systems, and diagnostic caps for use in such systems |
| CN101269257A (en) * | 2007-03-20 | 2008-09-24 | 深圳市微创医学科技有限公司 | Optical power therapentic equipment |
| WO2017070702A1 (en) * | 2015-10-23 | 2017-04-27 | Inari Medical, Inc. | Intravascular treatment of vascular occlusion and associated devices, systems, and methods |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023012406A1 (en) * | 2021-08-03 | 2023-02-09 | Modulight Corporation | Theranostic laser system |
| CN114377303A (en) * | 2022-03-23 | 2022-04-22 | 杭州高瓴医疗科技有限公司 | Flexible needle-shaped high-energy infrared water filtering therapeutic instrument |
| CN114377303B (en) * | 2022-03-23 | 2022-06-21 | 杭州高瓴医疗科技有限公司 | Flexible needle-shaped high-energy infrared water filtering therapeutic instrument |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109331345B (en) | 2019-11-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10993769B2 (en) | Devices and systems for ablation therapy | |
| US9149651B2 (en) | Non-invasive vascular treatment systems, devices, and methods of using the same | |
| JP2001505443A (en) | Balloon catheter for photodynamic therapy | |
| CN109331345B (en) | A kind of optical dynamic therapy diagnostic device for capableing of optical fiber puncture | |
| CN106955423B (en) | Blood vessel optical fiber catheter | |
| JP2009061083A (en) | Shock wave ablation system | |
| US10463876B1 (en) | Photodynamic therapy diagnostic device capable of optical fiber puncture | |
| WO2020019306A1 (en) | Optical fiber puncture needle tube and application thereof | |
| CN109331346B (en) | A kind of memory metal optical fiber puncture needle tubing | |
| CN109283688B (en) | A kind of reflection-type light uniforming device and its preparation and application | |
| CN109331347B (en) | A kind of optical fiber puncture needle tubing | |
| Zharov et al. | Laser combined medical technologies from Russia | |
| WO2020019307A1 (en) | Memory metal optical fiber puncture needle tube | |
| CN107213554B (en) | A kind of liquid light conduction device of intervention | |
| CN109603010B (en) | A kind of preparation method of even the optical fiber puncture needle of light and slit and light uniforming device out | |
| CN110339489A (en) | A kind of novel blood vessel optical fiber seal wire | |
| CN207679870U (en) | A kind of blood vessel fibre-optic catheter | |
| US10300295B2 (en) | Liquid light conducting device used in intervention | |
| Li | Deep photoacoustic imaging and acoustic cavitation mapping in shockwave lithotripsy | |
| CN109330636A (en) | A kind of intravascular memory metal lancing system and its application method | |
| US20240050767A1 (en) | Device and method for improving light penetration | |
| WO2021199978A1 (en) | Therapy device and therapy method | |
| Li et al. | Photoacoustic Imaging Guide Efficiently Tumor Therapy by Microbubble Explosion Induced by Ultrasonication | |
| RU119240U1 (en) | DEVICE FOR PHOTODYNAMIC THERAPY OF HYPERPLASIA OF THE PROSTATE | |
| RU94840U1 (en) | PUNCH LIGHT NEEDLE |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |