CN109310088A - Synergistic fungicidal mixture - Google Patents
Synergistic fungicidal mixture Download PDFInfo
- Publication number
- CN109310088A CN109310088A CN201780037210.XA CN201780037210A CN109310088A CN 109310088 A CN109310088 A CN 109310088A CN 201780037210 A CN201780037210 A CN 201780037210A CN 109310088 A CN109310088 A CN 109310088A
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- CN
- China
- Prior art keywords
- mixture
- agent
- fungicidal mixture
- group
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 100
- 230000000855 fungicidal effect Effects 0.000 title claims abstract description 60
- 230000002195 synergetic effect Effects 0.000 title abstract description 3
- 239000005808 Metalaxyl-M Substances 0.000 claims abstract description 27
- ZQEIXNIJLIKNTD-GFCCVEGCSA-N metalaxyl-M Chemical compound COCC(=O)N([C@H](C)C(=O)OC)C1=C(C)C=CC=C1C ZQEIXNIJLIKNTD-GFCCVEGCSA-N 0.000 claims abstract description 27
- XERJKGMBORTKEO-VZUCSPMQSA-N (1e)-2-(ethylcarbamoylamino)-n-methoxy-2-oxoethanimidoyl cyanide Chemical compound CCNC(=O)NC(=O)C(\C#N)=N\OC XERJKGMBORTKEO-VZUCSPMQSA-N 0.000 claims abstract description 25
- 239000005756 Cymoxanil Substances 0.000 claims abstract description 25
- -1 defoamers Substances 0.000 claims abstract description 18
- 239000000080 wetting agent Substances 0.000 claims abstract description 13
- 239000002270 dispersing agent Substances 0.000 claims abstract description 11
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 25
- UFEODZBUAFNAEU-NLRVBDNBSA-N fluoxastrobin Chemical compound C=1C=CC=C(OC=2C(=C(OC=3C(=CC=CC=3)Cl)N=CN=2)F)C=1C(=N/OC)\C1=NOCCO1 UFEODZBUAFNAEU-NLRVBDNBSA-N 0.000 claims description 24
- 239000005784 Fluoxastrobin Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000002518 antifoaming agent Substances 0.000 claims description 13
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 12
- 239000004563 wettable powder Substances 0.000 claims description 12
- 239000000853 adhesive Substances 0.000 claims description 10
- 230000001070 adhesive effect Effects 0.000 claims description 10
- 239000000843 powder Substances 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 7
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 6
- 235000011152 sodium sulphate Nutrition 0.000 claims description 6
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 4
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 150000007513 acids Chemical class 0.000 claims description 3
- 239000004927 clay Substances 0.000 claims description 3
- 239000002736 nonionic surfactant Substances 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 3
- 159000000000 sodium salts Chemical class 0.000 claims description 3
- 229940080313 sodium starch Drugs 0.000 claims description 3
- 239000008107 starch Substances 0.000 claims description 3
- 235000019698 starch Nutrition 0.000 claims description 3
- 229920002785 Croscarmellose sodium Polymers 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 claims description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
- 229930006000 Sucrose Natural products 0.000 claims description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 2
- CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 claims description 2
- 229940063655 aluminum stearate Drugs 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 229910052570 clay Inorganic materials 0.000 claims description 2
- 229960001681 croscarmellose sodium Drugs 0.000 claims description 2
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008121 dextrose Substances 0.000 claims description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 229920001519 homopolymer Polymers 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
- 235000019359 magnesium stearate Nutrition 0.000 claims description 2
- 235000010755 mineral Nutrition 0.000 claims description 2
- 239000011707 mineral Substances 0.000 claims description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 2
- 229920002401 polyacrylamide Polymers 0.000 claims description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 2
- 229940001593 sodium carbonate Drugs 0.000 claims description 2
- 235000017550 sodium carbonate Nutrition 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 235000002639 sodium chloride Nutrition 0.000 claims description 2
- 235000019832 sodium triphosphate Nutrition 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- 239000000375 suspending agent Substances 0.000 claims description 2
- 235000012222 talc Nutrition 0.000 claims description 2
- 239000000454 talc Substances 0.000 claims description 2
- 229910052623 talc Inorganic materials 0.000 claims description 2
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 2
- 239000011575 calcium Substances 0.000 claims 2
- 229910052791 calcium Inorganic materials 0.000 claims 2
- 229920000881 Modified starch Polymers 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- BIGPRXCJEDHCLP-UHFFFAOYSA-N ammonium bisulfate Chemical compound [NH4+].OS([O-])(=O)=O BIGPRXCJEDHCLP-UHFFFAOYSA-N 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 229920003020 cross-linked polyethylene Polymers 0.000 claims 1
- 239000004703 cross-linked polyethylene Substances 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229920005610 lignin Polymers 0.000 claims 1
- 235000019426 modified starch Nutrition 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims 1
- 150000004040 pyrrolidinones Chemical class 0.000 claims 1
- 229920005573 silicon-containing polymer Polymers 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- 241000233866 Fungi Species 0.000 abstract description 8
- 239000005730 Azoxystrobin Substances 0.000 abstract 1
- 239000001692 EU approved anti-caking agent Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- WFDXOXNFNRHQEC-GHRIWEEISA-N azoxystrobin Chemical compound CO\C=C(\C(=O)OC)C1=CC=CC=C1OC1=CC(OC=2C(=CC=CC=2)C#N)=NC=N1 WFDXOXNFNRHQEC-GHRIWEEISA-N 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000007884 disintegrant Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 description 28
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 28
- 238000012545 processing Methods 0.000 description 27
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 22
- 238000003756 stirring Methods 0.000 description 22
- 239000008240 homogeneous mixture Substances 0.000 description 18
- 238000002156 mixing Methods 0.000 description 18
- 239000000417 fungicide Substances 0.000 description 16
- 239000013618 particulate matter Substances 0.000 description 16
- 238000000034 method Methods 0.000 description 13
- 239000002245 particle Substances 0.000 description 13
- 239000000377 silicon dioxide Substances 0.000 description 11
- 231100000674 Phytotoxicity Toxicity 0.000 description 10
- 235000002595 Solanum tuberosum Nutrition 0.000 description 9
- 244000061456 Solanum tuberosum Species 0.000 description 9
- 239000000470 constituent Substances 0.000 description 8
- 239000008187 granular material Substances 0.000 description 8
- 238000002347 injection Methods 0.000 description 8
- 239000007924 injection Substances 0.000 description 8
- 238000001035 drying Methods 0.000 description 6
- 208000015181 infectious disease Diseases 0.000 description 6
- 239000005995 Aluminium silicate Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 5
- 235000012211 aluminium silicate Nutrition 0.000 description 5
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 5
- 238000011160 research Methods 0.000 description 5
- 239000002689 soil Substances 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- 229920005646 polycarboxylate Polymers 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 4
- 229940121375 antifungal agent Drugs 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000036253 epinasty Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000017074 necrotic cell death Effects 0.000 description 3
- 239000002002 slurry Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003945 anionic surfactant Substances 0.000 description 2
- 230000000843 anti-fungal effect Effects 0.000 description 2
- 239000003429 antifungal agent Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 235000015424 sodium Nutrition 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000007619 statistical method Methods 0.000 description 2
- 239000002023 wood Substances 0.000 description 2
- 125000003837 (C1-C20) alkyl group Chemical group 0.000 description 1
- ZNQVEEAIQZEUHB-UHFFFAOYSA-N 2-ethoxyethanol Chemical compound CCOCCO ZNQVEEAIQZEUHB-UHFFFAOYSA-N 0.000 description 1
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 1
- 229920005682 EO-PO block copolymer Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- 206010050392 Face injury Diseases 0.000 description 1
- JHXVRRJXCDAINK-UHFFFAOYSA-N NC(=O)N.N#CC#N Chemical compound NC(=O)N.N#CC#N JHXVRRJXCDAINK-UHFFFAOYSA-N 0.000 description 1
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 1
- 241000233622 Phytophthora infestans Species 0.000 description 1
- 235000011941 Tilia x europaea Nutrition 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 229940044197 ammonium sulfate Drugs 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 229920005551 calcium lignosulfonate Polymers 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
- 239000008116 calcium stearate Substances 0.000 description 1
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 238000010413 gardening Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 239000004571 lime Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000003123 plant toxin Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N41/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom
- A01N41/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a sulfur atom bound to a hetero atom containing a sulfur-to-oxygen double bond
- A01N41/04—Sulfonic acids; Derivatives thereof
- A01N41/06—Sulfonic acid amides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/34—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the groups, e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a synergistic fungicidal mixture comprising as active ingredients a combination of metalaxyl-M, cymoxanil and azoxystrobin in a weight ratio in the range of 1:1:0.5 to 1:3:30 and an excipient selected from the group consisting of dispersants, defoamers, wetting agents, disintegrants, anti-caking agents, carriers and binders. The fungicidal mixture of the present invention can prevent the development of resistance by fungi over a long period of time and has an enhanced fungicidal effect.
Description
Invention field
The present invention relates to a kind of Fungicidal mixtures.
Background technique
Crop, fruits and vegetables are easy to be invaded by fungi.It is true usually using fungicide prevention in agricultural and gardening
Bacterium.Most common and most widely used anti-fungal method may be implemented using synthesis of antifungal agents.Synthesis there are many being currently known
Fungicide, each manufacturer release largely based on the formula of these synthesis of antifungal agents to take precautions against fungi.Fluoxastrobin, enemy bacterium
The various compounds such as spirit, cymoxanil are typically used as fungicide.
Always suggest reducing the use of fungicide, to reduce the risk to human and environment.Correspondingly, needing to continuously improve
The fungicidal properties of fungicide, without increasing the toxicity to human and environment, to reach required biological effect with low rate of application.
Therefore, the present invention designs a kind of Fungicidal mixture with reinforcing effect.
Goal of the invention
Some purposes of the invention are as follows, and are met by following at least one specific embodiment.
It is an object of the invention to improve one or more problems of the prior art or at least provide one kind useful choosing
Select scheme.
It is an object of the present invention to provide a kind of Fungicidal mixtures.
It is a further object to provide a kind of Fungicidal mixtures with enhancing fungicidal action.
In being described below, other objects of the present invention and advantage incite somebody to action further to define, but these descriptions are not intended
It limits the scope of the invention.
Summary of the invention
The present invention relates to a kind of Fungicidal mixture, the active constituent for including includes Metalaxyl-M, cymoxanil and phonetic
Bacterium ester combination, weight ratio in 1:1:0.5 to 1:3:30 range, and from dispersing agent, defoaming agent, wetting agent, disintegrating agent, prevent
At least one excipient selected in the group of agglomeration agent, carrier and adhesive composition.
The invention further relates to a kind of methods for preparing Fungicidal mixture, comprising the following steps: mixing predefines
Anticaking agent, carrier and the Metalaxyl-M of quantity obtain substantially homogeneous mixture A；The Fluoxastrobin of mixing predetermined number,
Cymoxanil, wetting agent, dispersing agent, disintegrating agent obtain substantially homogeneous mixture B；Mix substantially homogeneous mixture A and basic
Uniform mixture B, obtains substantially homogeneous mixture C, and then grinding obtains substantially homogeneous powder, granule object size in 3 μ
Between m to 10 μm.Substantially homogeneous powder, water and the defoaming agent that predetermined number can be mixed, are then kneaded into dough；It squeezes
Dough obtains wet process extruded granule.The wet process extruded granule obtained is dried under controllable drying condition, then mistake
Sieve obtains granular size in the drying extruded granule of 0.5mm to 2mm.
Specific embodiment
It has been observed that Fluoxastrobin, cymoxanil and Metalaxyl-M have good fungicidal action.But their effect mould
Formula is single, is easy to produce resistance.
Therefore, the present invention designs a kind of fungicidal action and does not allow the synergy for being also easy to produce fungus resistant to kill very with enhancing
Bacterium mixture.
Applicant chances on, and is killed using the synergy of Metalaxyl-M, cymoxanil and Fluoxastrobin specific combination as active constituent
Fungal mix has Fungicidal effect.Fungicidal product needs suitable combination, generates resistance to avoid fungi.
Fungicidal mixture of the invention successfully enhances fungicidal action, and fungi is avoided to generate resistance.Fungicidal mixture of the invention
Amazing fungicidal action is shown, the effect summation being used alone beyond each ingredient.
In one aspect of the invention, the active constituent that Fungicidal mixture includes includes weight ratio in 1:1:0.5
It is combined to the Metalaxyl-M of 1:3:30, cymoxanil and Fluoxastrobin, and from dispersing agent, defoaming agent, wetting agent, disintegrating agent, anti-caking
At least one excipient selected in the group of block agent, carrier and adhesive composition.
Ingredient of the dispersing agent for the evenly dispersed Fungicidal mixture in dosage forms, especially active constituent.One
In a specific embodiment, dispersing agent be can be from sodium lignin sulfonate, calcium lignosulfonate, alkyl naphthalene sulfonic acid sodium salt, sulfonic acid
Aromatic polymer sodium salt, polycarboxylic acids homopolymer, ethylene oxide/propylene oxide (EO/PO) block copolymer and polycarboxylic acids copolymerization
At least one selected in the group of object sodium salt composition.Usual alkyl can be C1-C20 alkyl, the virtue of sulfonic acid aromatic polymer
Base is C1 to C20 aryl.
Defoaming agent can be used for preventing from forming foam.In a specific embodiment, defoaming agent can be from poly- diformazan
At least one selected in the group of radical siloxane powder and polydimethylsiloxane liquid composition.
Wetting agent is used for by reducing surface tension, moistens formula components with water-wet.In a specific embodiment, this hair
The wetting agent that bright mixture uses can be the group formed from nonionic surfactant, anionic surfactant and combinations thereof
At least one of middle selection.The non-limiting example of nonionic surfactant can be the alkane of number of moles of ethylene oxide 9 to 15
Ethoxy-ethanol.The non-limiting example of anionic surfactant includes alkylnaphthalene sulfonate, dialkyl naphthalene sulfonate salts, alkylnaphthalene
Sulfonate condensate liquid, lauryl sodium sulfate and neopelex.Other wetting agents that can be used are from alkyl ring
Oxidative ethane condensate liquid, aryl ethylene oxide condensate liquid, alkyl epoxy propane condensate liquid, aryl propylene oxide condensate liquid, alkyl second
At least one selected in oxygroup compound and the group of arylethoxy compound composition.The alkyl and aryl of usual wetting agent are C1-
C20 alkyl.
Disintegrating agent is to aid in the compound of substance fast decoupled in water.In a specific embodiment, the present invention is mixed
It closes the disintegrating agent that object uses and can be and derive from sodium chloride, sodium sulphate, ammonium sulfate, sodium carbonate, sodium bicarbonate, starch and starch
At least one selected in the group that object, sodium tripolyphosphate, croscarmellose sodium, crosslinked polyvinylpyrrolidone form.
Anticaking agent is for preventing Fungicidal mixture from agglomerating during storage.In a specific embodiment, prevent
Agglomeration agent can be at least one selected from the group that clay, precipitated silica and metallic stearate form.At another
In specific embodiment, metallic stearate can be from the group of zinc stearate, calcium stearate, magnesium stearate and aluminum stearate composition
Middle selection.
Carrier is used as diluent or filler in formula.Carrier can be from the group that clay, minerals and talcum form
Selection.
Adhesive is for the ingredient in adhesive mixture to assign required intensity.In a specific embodiment, it bonds
Agent can be to be selected from the group that polyvinyl alcohol, polyvinylpyrrolidone, polyacrylamide, dextrose, sucrose and lactose form
At least one.
Fungicidal mixture of the invention can be using the group that particle, wettable powder and suspending agent composition can be dispersed in water
The form of middle selection.
In another aspect of the present invention, a kind of method preparing Fungicidal mixture is also provided.The method is specifically
It is bright as follows:
Anticaking agent, carrier and the Metalaxyl-M for obtaining predetermined number, are mixed using blender, obtain base
This uniform mixture A.In a specific embodiment, Metalaxyl-M can be heated to 35 DEG C to 80 DEG C of temperature, then
It is sprayed on anticaking agent and carrier, the substantially homogeneous mixture A of stirring to obtain.
Fluoxastrobin, cymoxanil, wetting agent, dispersing agent, disintegrating agent and the adhesive for obtaining predetermined number, use stirring
Device mixes, and obtains substantially homogeneous mixture B.
Substantially homogeneous mixture A and substantially homogeneous mixture B are mixed in blender, obtain substantially homogeneous mixing
Object C.Then substantially homogeneous mixture C is ground into fine particulates size, obtains substantially homogeneous powder.It is specific at one
In embodiment, the particulate matter size of substantially uniform powder is in 3 μm to 10 μ ms.In a specific embodiment, make
It is milled with air injection and smashs substantially homogeneous mixture C to pieces.
Then substantially uniform powder, water and the defoaming agent of predetermined number are added to dough mixing machine, kneading obtains dough.
Then dough is handled in extruder, obtains wet process extruded granule.The dry wet process extrusion forming under controllable drying condition
Particle obtains dry extruded granule.
In a specific embodiment, dry extruded granule can be further sieved, obtains particulate matter size
The drying extruded granule of 0.5mm to 2mm.
In another the method according to the invention, can first using air injection mill smash to pieces/grind Fluoxastrobin and frost
Urea cyanogen obtains powder, then by powder and Metalaxyl-M, water, dispersing agent, wetting agent, adhesive, defoaming agent, disintegrating agent and load
Body mixing, obtains the slurries of total solids content 40% to 65%.The slurries of acquisition can be in spray dryer or bed spray
It is spray-dried in drier, obtains dry particle.It is sieved in the screen dry particle, obtains 100 μm of particulate matter size and arrive
850 μm of particle.
In another method of the invention, with water and wetting agent mixing Fluoxastrobin and cymoxanil in homogenizer, obtain
Substantially homogeneous mixture D.Substantially homogeneous mixture D is smashed to pieces as the mixture D of fine particulates size.In a typical case
In specific embodiment, smashed to pieces using wet milk execution.In a specific embodiment, the mixture of fine particulates size
The particulate matter size of D is 2 μm to 5 μm.Can by the mixture D of fine particulates size further with Metalaxyl-M, water, dispersion
Agent, adhesive, anti-caking agent, disintegrating agent, defoaming agent and carrier mixing, obtain the slurries of total solid content 40% to 65%.So
It is spray-dried afterwards with spray dryer or fluid bed spray dryer, obtains dry particle.Dry of sieving in the screen
Grain obtains 100 μm to 850 μm of particulate matter size of particle.
In another the method according to the invention, with anti-caking agent and carrier mixing Fluoxastrobin, cymoxanil and smart first frost
Spirit obtains substantially homogeneous mixture E.Substantially homogeneous mixture E is smashed to pieces in air injection is milled, and obtains particulate matter size
3 μm to 10 μm of premixing powder.In another container, obtains the water of predetermined number, dispersing agent, adhesive, moistens
Agent, disintegrating agent and defoaming agent, mixing obtain substantially homogeneous mixture F.In fluid bed processor, by substantially homogeneous mixing
Object F is sprayed in substantially homogeneous mixture E, and temperature is controlled at 30 DEG C to 50 DEG C, obtains substantially homogeneous mixture G.Can
Substantially homogeneous mixture G is further dried under the conditions of controlling temperature, obtains 100 μm to 1000 μm of granular size of dry particle.
Other possible mutation of the method for the present invention have also been devised.
Therefore, the present invention provides a kind of is killed very by the easy-to-use synergy of stablizing that Metalaxyl-M, cymoxanil and Fluoxastrobin form
A kind of preparation method of bacterium mixture and such mixture.
The present invention will be further illustrated by following experiment below, these experiments are merely to illustrate, are not interpreted as with any
Mode limits the scope of the invention.Experiment can be expanded to industry/commercial size below, and the result of acquisition can be extrapolated to industrial rule
Mould.
Test details
A: Fungicidal mixture and its preparation process
Embodiment 1
Sigma blender is added in 35gms silica and 153gms kaolin, is stirred 10 minutes.By 110gms essence first
White spirit is heated to 35 DEG C to 80 DEG C temperature ranges, obtains the Metalaxyl-M of melting, and blender is then added, and stirring mixture 2 is small
When, obtain mixture A.
By 215gms Fluoxastrobin, 211gms cymoxanil, 40gms alkyl naphthalene sulfonic acid sodium salt, 100gms polycarboxylate, 19gms
Ribbon stirrer is added in sodium lignin sulfonate, 5gms lactose, 110gms sodium sulphate, stirs 2 hours acquisition mixture B.
Mixture B is added in mixture A in ribbon stirrer, continues to stir 2 hours acquisition mixture Cs.
It smashs mixture C to pieces in injection is milled, obtains the wettable powder of particulate matter size 3 to 10micron.
Dough mixing machine is added in wettable powder, 2gms silica and 40gms water, stirring to obtain dough is added.
Dough is squeezed with basket extruder, obtains the particle of particulate matter size 0.8mm to 1.2mm, it is dry in 40 DEG C of fluidized beds
Continue to interfere in dry device, obtains final mixture product.
Embodiment 2
Sigma blender is added in 80gms silica and 153gms kaolin, is stirred 10 minutes.110gms is melted
Blender is added in Metalaxyl-M, stirs the mixture of formation 2 hours, obtains mixture A.
215gms Fluoxastrobin, 225gms cymoxanil, 40gms alkyl naphthalene sulfonic acid sodium salt, 60gms alkyl naphthalene sulfonic acid sodium salt is cold
Ribbon stirrer is added in lime set, 40gms sodium lignin sulfonate, 75gms sodium carbonate, stirs 2 hours acquisition mixture B.
Mixture B is added in mixture A in ribbon stirrer, continues to stir 2 hours acquisition mixture Cs.
It smashs mixture C to pieces in injection is milled, obtains the wettable powder of particulate matter size 3 to 10micron.
Dough mixing machine is added in wettable powder；2gm silica and 40gms water, stirring to obtain dough is added.
The dough obtained is squeezed with basket extruder, obtains the particle of particulate matter size 0.8mm to 1.2mm, is flowed at 40 DEG C
Change and continue to interfere in bed dryer, obtains final mixture product.
Embodiment 3
Sigma blender is added in 80gms silica and 153gms kaolin, is stirred 10 minutes.110gms is melted
Metalaxyl-M is heated to 35 DEG C to 80 DEG C temperature ranges, and blender is added in Metalaxyl-M, stirs mixture 2 hours, is mixed
Close object A.
By 232gms Fluoxastrobin, 211gms cymoxanil, 40gms alkyl naphthalene sulfonic acid sodium salt, 100gms polycarboxylate, 24gms
Ribbon stirrer is added in sodium lignin sulfonate, 48gms sodium sulphate, stirs 2 hours acquisition mixture B.
Mixture B is added in mixture A in ribbon stirrer, continues to stir 2 hours acquisition mixture Cs.
It smashs mixture C to pieces in injection is milled, obtains the wettable powder of particulate matter size 3 to 10micron.
Dough mixing machine is added in wettable powder, 2gm silica (as defoaming agent) and 40gms water, stirring to obtain is added
Dough.Dough is squeezed with basket extruder, the particle of particulate matter size 0.8mm to 1.2mm is obtained, in 40 degree of fluidized bed drying
Continue to interfere in device, obtains final mixture product.
Embodiment 4
Sigma blender is added in 40gms silica and 153gms kaolin, is stirred 10 minutes.100gms is melted
Metalaxyl-M is heated to 35 DEG C to 80 DEG C temperature ranges, and blender is added in Metalaxyl-M, stirs mixture 2 hours, is mixed
Close object A.
By 232gms Fluoxastrobin, 211gms cymoxanil, 25gms alkyl naphthalene sulfonic acid sodium salt, 50gms polycarboxylate, 21gms wood
Ribbon stirrer is added in quality sodium sulfonate, 166gms sodium sulphate, stirs 2 hours acquisition mixture B.
Mixture B is added in mixture A in ribbon stirrer, continues to stir 2 hours acquisition mixture Cs.It is ground in injection
It smashs mixture C in mill to pieces, obtains the wettable powder of particulate matter size 3 to 10micron.
Dough mixing machine is added in wettable powder, 2gm silica (as defoaming agent) and 40gms water, stirring to obtain is added
Dough.Dough is squeezed with basket extruder, the particle of particulate matter size 0.8mm to 1.2mm is obtained, in 40 degree of fluidized bed drying
Continue to interfere in device, obtains final mixture product.
Embodiment 5
Sigma blender is added in 40gms silica and 250gms kaolin, is stirred 10 minutes.By 13gms essence first frost
Spirit is heated to 35 DEG C to 80 DEG C temperature ranges, obtains the Metalaxyl-M of melting, and blender is then added, and stirs mixture 2 hours,
Obtain mixture A.
By 321gms Fluoxastrobin, 33gms cymoxanil, 25gms alkyl naphthalene sulfonic acid sodium salt, 50gms polycarboxylate, 21gms wood
Ribbon stirrer is added in quality sodium sulfonate, 10gms lactose, 235gms sodium sulphate, stirs 2 hours acquisition mixture B.
Mixture B is added in mixture A in ribbon stirrer, continues to stir 2 hours acquisition mixture Cs.
It smashs mixture C to pieces in injection is milled, obtains the wettable powder of particulate matter size 3 to 10micron.
Dough mixing machine is added in wettable powder, 2gms silica and 40gms water, stirring to obtain dough is added.
Dough is squeezed with basket extruder, obtains the particle of particulate matter size 0.8mm to 1.2mm, it is dry in 40 DEG C of fluidized beds
Continue to interfere in dry device, obtains final mixture product.
The explanation of table 1 optimizes according to active constituent of the invention and excipient, the shelf stability of Fungicidal mixture.
Table 1
AHS- accelerates storage research
The test of WST- wet screening
As it can be seen from table 1 embodiment 1-5 stablizes, even if suspending power parameter is not also bright after accelerating storage research
It is aobvious to reduce.
B: the biopotency research and phytotoxicity research biopotency of Fungicidal mixture:
To give the Fungicidal formula that concentration determination is prepared according to the embodiment of the present invention 1 to 5, using two-way possible tank
Hybrid combining, i.e. cymoxanil 50%WP+ Fluoxastrobin 25%SC (tank mixing), (tank is mixed by Metalaxyl-M 25%WP+ Fluoxastrobin 25%SC
Close) & cymoxanil 50%WP+ Metalaxyl-M 25%WP (tank mixing) and various independent fungicides, i.e. Fluoxastrobin 25%SC,
Cymoxanil 50%WP& Metalaxyl-M 25%WP, untreated control group, for potato morning late blight.Using being mounted with solid-cone
The knapsack sprayer of shape nozzle, using fungicide as lobate spray.When field starts to occur disease, start to go and buy Chinese medicine.
It was sprayed with 10 days for interval.
Disease Visual symptoms appearance is recorded before the 1st sprinkling, records later observation result after sprinkling in every 10 days.In order to remember
Record observation gives a mark to the leaf of every piece of 10 plants of soil crop as a result, according to late blight and early blight Disease Score scale (0-9),
As shown in table 2.
Table 2: disease assessment
Percentage disease index (PDI) is calculated according to following formula:
PDI value is converted by angular transformation, it is for statistical analysis.Disease control DC (%) is calculated according to following formula.
Yield:
Output per hectare (q/ha), statistical when recording the yield in every block of soil, calculation processing yield, and being converted to harvest
Analyse data.
Phytotoxicity:
Different disposal measure is taken to 10 crops in every block of soil, observation is injured caused by crop, considers plant poison
Property symptom, i.e. blade tip and blade face injury, wilting, veinclearing disease, necrosis, epinasty and hyponasty.Before sprinkling, the 1st after application,
3,5,7,10 and 15 days records observe result.For the phytotoxicity research that blade tip and blade face injure, table 3 provides the scale used
(0-10)。
Table 3: phytotoxicity marking scales (PRS)
Statistical analysis: variance analysis is calculated using OPSTAT computer software programs.
Table 4: biopotency (Rabi 2016-17) of the different fungicide processing to the late blight of potato
Percentage occurs for PDI- disease
PDC- disease control percentage
Number of days after DAA- application
NS- is inessential
G a.i./ha-g active constituent/hectare
It is that table 4 is summarized the result shows that, when starting test, any crop illustrates to test soil all without late blight
Uniformity in processing.After applying 10 days for the first time, observe that late blight highest infects (10.75%) in control group T12.It can send out
It is existing, untreated control group is compared, all fungicide processing can significantly reduce disease severity.T1 to T3 observes late blight
Minimum infection (0.00%), corresponding T4 (0.38%).These processing (T1 to T4) are substantially better than remaining processing.
After second of application 10 days, observe that disease highest infects (25.19%) in control group.T1 observes late blight most
Low infection (1.12%), alignment processing T2 (1.49%), T3 (1.86%) and T4 (1.86%).These processing (T1 to T4) are obvious
Better than remaining processing.
After third time application 10 days, the trend similar with applying for the second time is observed.T1 observes the minimum infection of late blight
(2.97%), corresponding T2 (3.71%), T3 (4.08%) and T4 (4.45%).Untreated control group observes that disease highest infects
(55.19%).These processing (T1 to T4) are substantially better than remaining processing.
Processing T1 observes highest disease control percentage (PDC) (94.62%), is T2 (93.28%), T3 respectively later
(92.61%) and T4 (91.94%).Processing T8 observes minimum disease control (55.03%), is T7 respectively later
(67.78%) and T6 (69.80%).
Table 5: biopotency (Rabi 2016-17) of the different fungicide processing to target
Percentage occurs for PDI- disease
PDC- disease control percentage
Number of days after DAA- application
NS- is inessential
G a.i./ha-g active constituent/hectare
Table 5 the result shows that, when on-test, start early blight occur, but there is no significant difference between handling, this says
Bright transmission is uniform.After application for the first time 10 days, observe that disease highest infects (5.19%) in control group.T1 (0.00%)
The minimum infection of disease, corresponding T2 (0.38%), T3 (0.75%) and T4 (0.75%) are observed with T5 (0.00%).These processing
(T1 to T5) is substantially better than remaining processing.
After second of application 10 days, disease indication is not observed in processing T1 to T5.Control group observes disease highest sense
It contaminates (13.71%).T1 (0.00%) and T5 (0.00%) observes the minimum infection of disease, corresponding T2 (0.38%), T3
(0.75%) and T4 (0.75%).These processing (T1 to T5) are substantially better than remaining processing.
After third time application 10 days, similar trend is observed.The minimum infection of disease is observed in processing T5 (0.00%), corresponding
T1&T2 (0.38%), later T4 (0.75%) and T3 (1.12%).Untreated control group observes that disease highest infects
(17.41%).(T1 to T5) is handled better than remaining processing.
Processing T5 (100%) observe highest disease control percentage (PDC), be respectively later T1&T2 (97.82%),
T4 (95.69%), T3 (93.57%).Minimum disease control is observed in processing T7 (27.63%), is T6&T11 respectively later
(31.88%), T10 (48.94) and T9 (55.31%).
Table 6: different fungicides handle the influence (Rabi 2016-17) to potato yield
As can be seen from Table 6, all processing significantly improve yield (178.67q/ha) compared to untreated control group.Handle T1
(246q/ha) observes maximum output, is significantly better than remaining processing, corresponding T2 (240.33q/ha), T3 (238q/ha) and T4
(230q/ha) is T5 (226.67q/ha) later.Untreated control group (178.67q/ha) observes minimum output.
Table 7: different fungicide processing influence (Rabi 2016-17) for the phytotoxicity of potato
Phytotoxicity symptom-blade tip and blade face are injured, wilting, veinclearing disease, necrosis, epinasty and hyponasty
G a.i./ha-g active constituent/hectare
Various fungicide combinations are sprayed with dosage X (500g/ha) and 2X (1000g/ha), record is to Ma Ling in table 7
The phytotoxicity of potato crop influences, wilting if blade tip and blade face injure, veinclearing disease, necrosis, epinasty and hyponasty.?
Before sprinkling, 3 after application, these phytotoxicity parametric results are observed within 5,7,10 and 15 days.After sprinkling processing, not in potato crop
On observe phytotoxicity.Potato crop in the soil combined with maximum dose level@1000g/ha applications of fungicides does not have
It is found negative effect.
Therefore, Fungicidal mixture of the invention (Fluoxastrobin, cymoxanil and Metalaxyl-M) can effectively control horse
The early blight and late blight of bell potato.Wherein Fluoxastrobin 20%+ cymoxanil 20%+ Metalaxyl-M 10%WG is highly effective.The present invention
The effect of Fungicidal agent be far superior to commercial fungicide (Fluoxastrobin 25%SC, cymoxanil 50%WP and Metalaxyl-M
25%WP) and their two-way possible tank hybrid combining.The yield of Fungicidal mixture raising potato.Use this hair
Bright Fungicidal mixture is not observed on the influence of the phytotoxicity of potato.
Therefore, Fungicidal mixture of the invention has the synergistic effect of control disease.In addition, Fungicidal mixture is in length
Phase use when it is effective, prevent fungi generate resistance, compared to Fluoxastrobin 25%SC, cymoxanil 50%WP and Metalaxyl-M 25%WP with
And their two-way possible tank hybrid combining, Crop damage can be limited.
Technical advantage and economic significance
Present invention described above has multiple technical advantages, including but not limited to realizes a kind of following antifungal mixing
Object:
Enhance fungicidal action；
Prevent fungi from generating resistance.
The description of above-mentioned specific embodiment sufficiently discloses the generality of specific embodiment in the present invention, be not detached from
Under the premise of universal, other people easily can modify and/or adjust such specific embodiment with existing knowledge
Various applications.Therefore, these adjustment and modification should be encompassed by and disclosed specific embodiment is comparable contains
In justice and range.It should be appreciated that the wording and term that use herein are the purposes in order to describe rather than limited.Therefore, although
Specific embodiment in text describes preferred specific embodiment, and known those skilled in the art recognizes described
Specific embodiment spirit and scope in, can modify to the specific embodiment in text.
Word " comprising " in this specification or its deformation are all understood to imply comprising a kind of element, whole
Several or step or one group of element, integer or step, but be not excluded for any other element, integer or step or element, integer or
Step group.
The usage of word " at least " or "at least one" shows using one or more elements or ingredient or quantity, the present invention
Use in embodiment is to realize one or more desired objects or result.
The discussion of the All Files, behavior, material, equipment, the article that include in this specification etc. is to aim at offer of the present invention
One context environmental.This be not an admission that some or all of these data just constitute this patent application it
The preceding common sense for being just present in any national related fields.
The numerical value of various physical parameters, size or the quantity mentioned is only approximation, it is thus understood that above/below distributing to
The value of the numerical value of these parameters, size or quantity is also within the scope of the present invention, unless having in this specification specific opposite
Statement.
Although by the considerable component and component parts for focusing on preferred embodiment, it is to be understood that
Under the premise of without departing from principle of the present invention, can there are many embodiment, and preferred embodiment can be made it is many more
Change.Content according to the present invention, those skilled in the art will be easily to the preferred embodiment of the present invention and other implementations
These and other variation of mode made, it is possible thereby to which the description that embodiment of above is well understood is only the present invention
The illustrative description of content, describes and not restrictive.
Claims (11)
1. a kind of Fungicidal mixture, includes:
A. Metalaxyl-M；
B. cymoxanil；
C. Fluoxastrobin；
D. at least one excipient.
2. Fungicidal mixture as described in claim 1, wherein the weight ratio of Metalaxyl-M, cymoxanil and Fluoxastrobin is
1:1:0.5 to 1:3:30.
3. Fungicidal mixture as described in claim 1, wherein the excipient from dispersing agent, defoaming agent, wetting agent,
It is selected in the group that disintegrating agent, anticaking agent, carrier and adhesive form.
4. Fungicidal mixture as claimed in claim 3, wherein the dispersing agent is from sodium lignin sulfonate, lignin
Sulfoacid calcium, alkyl naphthalene sulfonic acid sodium salt, sulfonic acid aromatic polymer sodium salt, polycarboxylic acids homopolymer, ethylene oxide/propylene oxide (EO/
PO) at least one selected in the group of block copolymer and co-poly carboxylic acid sodium salt composition.
5. Fungicidal mixture as claimed in claim 3, wherein the defoaming agent is from dimethyl silicone polymer powder
With at least one selected in the group of polydimethylsiloxane liquid composition.
6. Fungicidal mixture as claimed in claim 3, wherein the wetting agent is from nonionic surfactant, yin
At least one selected in the group of ionic surface active agent and combinations thereof composition.
7. Fungicidal mixture as claimed in claim 3, wherein the disintegrating agent is from sodium chloride, sodium sulphate, sulfuric acid
Ammonium, sodium carbonate, sodium bicarbonate, starch and starch derivatives, sodium tripolyphosphate, croscarmellose sodium, crosslinked polyethylene
At least one selected in the group of pyrrolidones composition.
8. Fungicidal mixture as claimed in claim 3, wherein the anticaking agent is from zinc stearate, stearic acid
At least one selected in the group of calcium, magnesium stearate and aluminum stearate composition.
9. Fungicidal mixture as claimed in claim 3, wherein what the carrier was formed from clay, minerals and talcum
It is selected in group.
10. Fungicidal mixture as claimed in claim 3, wherein described adhesive is from polyvinyl alcohol, polyethylene pyrrole
At least one selected in the group that pyrrolidone, polyacrylamide, dextrose, sucrose and lactose form.
11. Fungicidal mixture as described in claim 1, wherein the Fungicidal mixture is using dispersible in water
At least one dosage form selected in the group of grain, wettable powder and suspending agent composition.
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| PCT/IB2017/053610 WO2017216776A1 (en) | 2016-06-17 | 2017-06-17 | A synergistic fungicidal composition |
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|---|---|---|---|---|
| ATE238661T1 (en) * | 1998-07-30 | 2003-05-15 | Nihon Nohyaku Co Ltd | FUNGICIDE COMPOSITION CONTAINING A 1,2,3-THIADIAZOLE DERIVATIVE AND USE THEREOF |
-
2017
- 2017-06-17 WO PCT/IB2017/053610 patent/WO2017216776A1/en active Application Filing
- 2017-06-17 CN CN201780037210.XA patent/CN109310088A/en active Pending
- 2017-06-17 RU RU2018144260A patent/RU2738360C2/en active
-
2018
- 2018-12-13 PH PH12018502636A patent/PH12018502636A1/en unknown
- 2018-12-13 CO CONC2018/0013439A patent/CO2018013439A2/en unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002021918A1 (en) * | 2000-09-12 | 2002-03-21 | Syngenta Participations Ag | Fungicidal compositions |
| WO2006060272A2 (en) * | 2004-11-30 | 2006-06-08 | Syngenta Participations Ag | Process and composition for coating propagation material |
| WO2006128655A2 (en) * | 2005-05-31 | 2006-12-07 | Syngenta Participations Ag | Method of mollusc control |
| CN102388897A (en) * | 2011-10-10 | 2012-03-28 | 尹小根 | Antibacterial composition containing azoxystrobin and cymoxanil |
| CN105409963A (en) * | 2015-12-19 | 2016-03-23 | 青岛奥迪斯生物科技有限公司 | Sterilization composition containing efficient metalaxyl-M and azoxystrobin |
| CN105475317A (en) * | 2015-12-19 | 2016-04-13 | 青岛奥迪斯生物科技有限公司 | Sterilization combination containing efficient metalaxyl-M and cymoxanil |
Non-Patent Citations (1)
| Title |
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| 罗彦涛 等: "马铃薯晚疫病菌对不同药剂敏感性及相应药剂田间防效验证", 《农药》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2738360C2 (en) | 2020-12-11 |
| WO2017216776A1 (en) | 2017-12-21 |
| RU2018144260A (en) | 2020-07-17 |
| PH12018502636A1 (en) | 2019-10-21 |
| CO2018013439A2 (en) | 2019-01-18 |
| RU2018144260A3 (en) | 2020-07-17 |
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