CN109303970A - A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery - Google Patents
A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery Download PDFInfo
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- CN109303970A CN109303970A CN201811157385.7A CN201811157385A CN109303970A CN 109303970 A CN109303970 A CN 109303970A CN 201811157385 A CN201811157385 A CN 201811157385A CN 109303970 A CN109303970 A CN 109303970A
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- drug
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- dosing tank
- snorkel
- drug reservoir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
- A61H35/00—Baths for specific parts of the body
- A61H35/04—Baths for specific parts of the body for the nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0618—Nose
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Otolaryngology (AREA)
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- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Rehabilitation Therapy (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The present invention discloses the device and drug reservoir of a kind of quantitative intranasal brain-targeted drug delivery, the device includes spray head and bottle body, the spray head is connected or is removably mounted on the bottle body, dosing tank, gas extrusion cabin and the accommodating cabin for holding medicine module are respectively equipped in the bottle body, it is equipped with the partition that can be inserted into and extract between the dosing tank and accommodating cabin, cartridge clip spline structure is additionally provided in the accommodating cabin for pushing drug moiety to dosing tank；The drug moiety includes the drug reservoir equipped with drug of sealing, and the chamber wall of the drug reservoir is made of hard material, and the position that the arrival end of the delivery tube and the gas outlet end of the snorkel I are corresponded on chamber wall is set as sealing membrane structure.The device is detachable, and modularized design is conveniently assembled and used, and it is convenient to clean and nurse, and the spray head of drug delivery device is detachable, can be dedicated with special messenger, regularly updates and is also possible to prevent drug contamination, cross-infection.The separation of medicine instrument is also convenient for storage, management, is suitble to assembly army.
Description
Technical field
The invention belongs to the field of medical instrument technology, and in particular to a kind of quantitatively device of intranasal brain-targeted drug delivery and drug storage
Container.
Background technique
Blood-brain barrier is one layer of natural barrier between body circulation and central nervous system, is playing barrier action,
While stopping pathogenic microorganism and harmful substance to enter brain, also counteract that many drugs enter central nervous system via blood circulation
System plays therapeutic effect.Existing many medications, such as through cranium in-situ injection, through subarachnoid injection, because of wound
Property strong, operating technology require the reasons such as height, it is difficult to be widely used in clinic.
The branched ending of olfactory nerve is distributed in olfactory mucosa, as one of 12 pairs of cranial nerves, exists so that external substance passes through
Olfactory nerve and its related pathways enter brain in the presence of possible.In addition, the distribution of nasal cavity Zhong Yiyou trigeminal neuralgia branch, and schneiderian membrance exists
Widely distributed blood vessel and lymphatic vessel can be linked up with encephalic, therefore drug intranasal enters brain and can avoid blood brain screen to a certain extent
Barrier, and administration difficulty can be farthest reduced, it can theoretically increase drug relative to oral administration, intravenous injection administration
The dosage for entering cranium promotes the function and effect of drug.
Current nose administration device is ripe day by day in terms of the dispersion of drug, transmission and distribution.It is clear from simple nasal cavity
Watering can, nasal spray are washed, to the application of ultrasonic atomizatio, osmotic pumps on nose administration device, distribution of the drug in nasal cavity is
It can achieve widely distributed and finely dispersed purpose.However most devices are stored in drug or device cleaning, device are long-term
Be recycled etc. Shortcomings.
Traditional direct nasal drip is using existing mixed or premix the direct collunarium of drug, it is advantageous that can neatly basis
The demand of user adjusts dosage, also without the concern for the Preservation of drug.However configuration drug is needed before collunarium,
The workload of medical staff is increased in clinical use, and there may be biggish mistakes for the operating result of different medical workers
Difference, and for patients, complicated operation reduces the compliance used.
The integrated design of intranasal drug and device is common in liquid spray, osmotic pumps, ultrasonic atomizing device etc., administration
Convenient, drug is uniformly mixed, and can effectively improve the therapeutic effect of nose administration.And the part of the not anti-backflow of many devices,
It is directly linked up with the external world, increases the rotten possibility of drug contamination, reduce drug uses validity period.And nasal cavity is to have collarium
Border, the device, which is used for a long time, the risk for causing secondary infection.And most integrated apparatus are difficult to dismantle, therefore clean the barrier of nursing
Hinder the generation for also resulting in pollution.And once produce, built-in drug can not be replaced, and be finished rear device and often also have no again
The possibility utilized brings the waste of resource to a certain extent.The device being administered in conjunction with ultrasonic atomizing device designs complicated, cost
It is high, and the validity of Vltrasonic device still needs to be proved.
To solve the above problems, we have devised it is a kind of based on ammunition loading and using air pressure as the dress of the principle of power
It sets, detachable apparatus and premix drug is separated, and drug is filled to special drug reservoir according to common or recommended dose
In, achieve the purpose that simple, efficient, quantitative, cleaning is administered by being applied in combination for the two.
Summary of the invention
The purpose of the present invention is to provide the devices and drug reservoir of a kind of quantitative intranasal brain-targeted drug delivery.
The purpose of the present invention can be achieved through the following technical solutions:
A kind of device of quantitative intranasal brain-targeted drug delivery, which includes spray head and bottle body, and the spray head is connected or can
Disassembly is mounted on the bottle body, dosing tank, gas extrusion cabin is respectively equipped in the bottle body and for holding medicine mould
The accommodating cabin of block is equipped with the partition that can be inserted into and extract, also sets in the accommodating cabin between the dosing tank and accommodating cabin
There is cartridge clip spline structure for pushing drug moiety to dosing tank, the dosing tank is connected to the gas by snorkel I and squeezes
Ballasting, the snorkel I are equipped with the cooling gas check valve opened towards dosing tank, and the gas extrusion cabin passes through snorkel
II connection is extraneous, and the outlet end of the snorkel II is equipped with the cooling gas check valve opened towards gas extrusion cabin, the gas
It squeezes and is equipped with piston in cabin, spring is installed between the piston and the bulkhead in gas extrusion cabin, is equipped in the spray head
Delivery tube, the arrival end of the delivery tube are arranged in the dosing tank；
The drug moiety includes the drug reservoir equipped with drug of sealing, and the chamber wall of the drug reservoir is by hard
Material is made, and the position that the arrival end of the delivery tube and the gas outlet end of the snorkel I are corresponded on chamber wall is set as
Seal membrane structure；
The gas outlet end of the arrival end of the delivery tube and the snorkel I is the tip made of hard material, just
Sealing membrane structure described in puncturing is inserted into the drug reservoir and guarantees the sealing state of drug reservoir.
As a kind of optimal technical scheme, the gas outlet end of the arrival end of the delivery tube and the snorkel I is distinguished
Positioned at the top of the dosing tank, the sealing membrane structure includes seal pipe and the film for close encapsulation pipe upper end,
The lower end of the seal pipe of the corresponding delivery tube arrival end is located at the bottom of the drug reservoir and is located under the liquid level of medical fluid, right
It answers the lower end of the seal pipe of I gas outlet end of snorkel to be located at the top of the drug reservoir and is located at the liquid level of medical fluid
On.It is further preferred that the upper end of the seal pipe is funnel-form, the film is as the funnelform bottom surface to sealing
Pipe is sealed (i.e. the film is arranged in hopper base).
The side wall of the dosing tank, which is equipped with, takes medicine window for taking out used drug moiety.
Drug storage cabin is additionally provided in the bottle body, the drug storage cabin is equipped with hatchcover.
The II gas access end of snorkel is equipped with strainer.
The cartridge clip spline structure includes push plate and substrate, and spring is equipped between the push plate and substrate, described
Push plate pushes drug moiety to dosing tank by the elastic force that the spring being mounted between the push plate and the substrate generates.
One end insertion of the substrate is arranged in the groove on the accommodating cabin bulkhead, and the other end of the substrate uses
Lock is fixed.
The partition passes through between the jack insertion being located on the bulkhead dosing tank and accommodating cabin.
The chamber wall of a kind of drug reservoir, the drug reservoir is made of hard material, and be additionally provided on chamber wall two it is close
Seal membrane structure；The sealing membrane structure includes seal pipe and the film for close encapsulation pipe upper end, one of them is close
The lower end of tube sealing is located at the bottom of the drug reservoir and is located under the liquid level of medical fluid, and the lower end of another seal pipe is located at described
The top of drug reservoir and be located at medical fluid liquid level on.
Above-mentioned drug reservoir, sealing membrane structure described in two is located at the upper end of the drug reservoir, described
The upper end of seal pipe is funnel-form, and the film is sealed seal pipe as the funnelform bottom surface.
The device and drug reservoir for the quantitative intranasal brain-targeted drug delivery that the present invention designs have the advantage that
(1) detachably, modularized design is conveniently assembled and is used, and it is convenient to clean and nurse, drug delivery device
Spray head it is detachable, can be dedicated with special messenger, regularly update be also possible to prevent drug contamination, cross-infection.Point of medicine instrument
From storage, management is also convenient for, it is suitble to assembly army,
(2) similar ammunition loads the working mechanism of sample, and soldier is using having natural cordial feeling, the novel sense that crowd uses
All be conducive to improve compliance.
(3) diversified drug moiety can be designed according to actual needs, reached a device multipurpose, cut drug moiety
It is interior the form of drug to be made by less limitation with loading powder, aqua, gel, the principle blowed based on filtering gas.
(4) novel in design, principle is illustrated, and facilitates production.Reserved chamber space can not only store drug, but also after being
Continuous further design and innovation provide enough spaces.
(5) thinking is novel, the thinking set of common nose administration device is jumped out, in conjunction with the quick hair of nowadays 3D printing technique
Exhibition, such design fast and easy production, and convenient for being improved according to itself specific demand.
Detailed description of the invention
Structure chart when Fig. 1 is the administration of the device of quantitative intranasal brain-targeted drug delivery.
Fig. 2 is the structure chart after the administration of the device of quantitative intranasal brain-targeted drug delivery.
Fig. 3 is the facing structure figure of drug reservoir.
Fig. 4 is the overlooking structure figure of drug reservoir.
Specific embodiment
As illustrated in figs. 1 and 2, a kind of device of quantitative intranasal brain-targeted drug delivery, which includes spray head 1 and bottle body 2, institute
The spray head 1 stated be connected or be removably mounted on the bottle body 2 (preferably detachable installation, it is described when detachable installation
Spray head 1 and bottle body 2 are buckle-type or screw-type connection, but not limited to this), dosing tank 3, gas are respectively equipped in the bottle body 2
Body squeezes cabin 4 and the accommodating cabin 5 for holding medicine module 6, be equipped between the dosing tank 3 and accommodating cabin 5 can be inserted into and
The hard partition 7 of extraction is additionally provided with cartridge clip spline structure in the accommodating cabin 5 for pushing drug moiety 6 to dosing tank 3, institute
The dosing tank 3 the stated gas extrusion cabin 4 described by the connection of snorkel I 8, the snorkel I 8 are equipped with towards dosing tank 3
The cooling gas check valve of opening, the gas extrusion cabin 4 is extraneous by the connection of snorkel II 9, the outlet end of the snorkel II 9
Equipped with the cooling gas check valve opened towards gas extrusion cabin 4, piston 10, the piston are equipped in the gas extrusion cabin 4
Spring 11 is installed between 10 and the bulkhead in gas extrusion cabin 4, is equipped with delivery tube 12, the delivery tube 12 in the spray head 1
Arrival end be arranged in the dosing tank 3；
The drug moiety 6 includes the drug reservoir 6-1 equipped with drug of sealing, the container of the drug reservoir 6-1
Wall is made of hard material, and the arrival end of the delivery tube 12 and the gas outlet end of the snorkel I 8 are corresponded on chamber wall
Position be set as sealing membrane structure；As a kind of optimal technical scheme, the arrival end and the snorkel I of the delivery tube 12
8 gas outlet end is located at the top of the dosing tank 3, and the sealing membrane structure includes seal pipe (6-11,6-
12) and for close encapsulation pipe upper end film (6-13,6-14), the seal pipe 6-11's of corresponding 12 arrival end of delivery tube
Lower end is located at the bottom of the drug reservoir 6-1 and is located under the liquid level of medical fluid, corresponding I 8 gas outlet end of snorkel
The lower end of seal pipe 6-12 is located at the top of the drug reservoir 6-1 and is located on the liquid level of medical fluid.It is further preferred that described
The upper end of seal pipe (6-11,6-12) is funnel-form, and the film (6-13,6-14) is arranged in hopper base.
The arrival end of the delivery tube 12 and the gas outlet end of the snorkel I 8 are the tip made of hard material,
Convenient for puncturing the film (6-13,6-14) of the sealing membrane structure, to be inserted into the drug reservoir 6-1 interior and guarantee to store up
The sealing state of medicine container 6-1.
The side wall of the dosing tank 3, which is equipped with, takes medicine window (being not drawn into figure) for taking out used drug moiety 6.
Drug storage cabin 12 is additionally provided in the bottle body 1, the drug storage cabin 12 is equipped with hatchcover 14.The snorkel II 9
Gas access end be equipped with strainer.
The cartridge clip spline structure includes push plate 15 and substrate 16, is equipped with spring between the push plate 15 and substrate 16
11, the elastic force that the push plate 15 is generated by the spring 11 that is mounted between the push plate 15 and the substrate 16 is by drug mould
Block 6 pushes dosing tank 3 to.
One end insertion of the substrate 16 is arranged in the groove 17 on accommodating 5 bulkhead of cabin, for helping to fix, institute
The other end for stating substrate is fixed using lock 18, and cartridge clip spline structure can be removed by opening lock 18.
The partition 7 passes through jack (being not drawn into the figure) insertion being located on the bulkhead dosing tank 3 and accommodating cabin 5
Between.
As shown in Figure 3 and Figure 4, a kind of drug reservoir 6-1, the chamber wall of drug reservoir 6-1 are made of hard material (often
Hard medical grade plastic materials), when preventing from pressurizeing to drug reservoir 6-1, drug reservoir 6-1 deformation, and also set on chamber wall
There are two seal membrane structure；The sealing membrane structure includes seal pipe (6-11,6-12) and for close encapsulation pipe
The film (6-13,6-14) at end, the lower end of one of seal pipe 6-11 are located at the bottom of the drug reservoir 6-1 and are located at medicine
Under the liquid level of liquid, the lower end of another seal pipe 6-12 is located at the top of the drug reservoir 6-1 and is located on the liquid level of medical fluid.
The sealing membrane structure is made of latex or silica gel material.
Sealing membrane structure described in two is located at the upper end of the drug reservoir 6-1, the seal pipe (6-11,
Upper end 6-12) is funnel-form, and the film (6-13,6-14) is arranged in hopper base.
In the device of the invention, the spray head 1 is led to by the hard reticular structure 1-1 package medical fluid with certain plasticity
The delivery tube 12 crossed, then formed in the surface of hard reticular structure 1-1 cladding silica gel spline structure 1-2.The hard is netted
Structure 1-1 Web materials made of common hard medical grade plastic materials.
When the spray head 1 and bottle body 2 is detachably installed, the spray head 1 and bottle body 2 are that buckle-type or screw-type connect
It connects, delivery tube 12 therein is also classified into two sections, and upper section is located in spray head 1, and lower section is located at bottle body 2, and spray head 1 and bottle body 2 are detachable
When connection, interface is equipped with sealing ring, and two sections of delivery tube 12 are tightly joined together.
The hatchcover 14 in the drug storage cabin 13 is equipped with lock spline structure, for protecting the drug moiety 6 saved in cabin.
Drug moiety 6 is provided with i.e. configured drug/device cleaning physiological saline etc. when production, can also be according to need
Carry out drug moiety design.The drug moiety 6 pierces through the drug reservoir by delivery tube 12 and snorkel I 8 respectively
The film (6-13,6-14) that membrane structure is sealed on 6-1 is inserted into the drug reservoir 6-1 and guarantees drug reservoir 6-1
Sealing state.The side wall of the dosing tank 3, which is equipped with, takes medicine window for taking out used drug moiety 6.Drug moiety 6 uses
After, extract partition 7 out, opening takes medicine window, drug moiety 6 is pressed with subordinate, by drug moiety 6 from the entrance of the delivery tube 12
It is removed on the gas outlet end of end and the snorkel I 8, takes out used drug moiety 6.
Cooling gas check valve in the snorkel I 8 is similar to heart valve sample, opens towards drug moiety 6, lives in pressing
It can be opened under the gas pressure that plug 10 generates, gas can enter drug moiety 6, the medical fluid in extrusion drug moiety 6/solidifying
Glue ensures that solutions/gels smoothly spray, and can close after the completion of administration prevents medical fluid adverse current from polluting.
The gas access end of the snorkel II 9 is equipped with strainer, is used to air pressure balance in ensuring equipment, filtering enters device
Interior air ensures that drug is not contaminated.
The outlet end of the snorkel II 9 is equipped with towards the cooling gas check valve opened to gas extrusion cabin 4, presses piston 10
When close, prevent gas from escaping through snorkel II 9, after the completion of administration process, spring back suction function in bring cabin in spring 11
Lower opening, gas enter gas extrusion cabin 4.Guarantee device internal and external pressure balance, prepares for administration next time.
Hard partition 7 between the dosing tank 3 and accommodating cabin 5 is set, extraction can be inserted, device is used when not used
Completely cut off accommodating cabin 5 and dosing tank 3, prevent the drug moiety 6 in accommodating cabin 5 from entering in dosing tank 3 and being punctured, when use extracts
Partition 7, under the effect of spring 11 drug moiety 6 it is automatic on be filled in dosing tank 3, turn back to again at this time partition 7 can isolate it is adjacent
Two drug moieties 6, the liquid medicine contamination for preventing not used drug moiety 6 to be squeezed or overflow.
There are multiple spring spline structures between the bulkhead and piston 10 in gas extrusion cabin 4, while ensureing leakproofness, by squeezing
The high pressure gas that pressure generates, which is used to squeeze medical fluid, smoothly leaves drug moiety 6, into nasal cavity designated position.The piston 10 by
Rubber-like material is made.
The workflow of apparatus of the present invention:
(1) lock 18 is opened, cartridge clip spline structure is taken out, partition 7 is in insert state, opens hatchcover 14, is taken out several
Drug moiety 6 is packed into the opening of drug delivery device bottom in the right direction, reinstalls cartridge clip spline structure, and buckle lock 18.
(2) partition 7 to be extracted, drug moiety goes upward to dosing tank 3 under the action of cartridge clip spline structure, it is inserted into partition 7,
Film (6-13,6- that membrane structure is sealed on the drug reservoir 6-1 are pierced through respectively in the tip of delivery tube 12 and snorkel I 8
14) it is inserted into the drug reservoir 6-1 and guarantees the sealing state of drug reservoir 6-1.
(3) nasal cavity is inserted into 1 upper end of the spray head of device, presses piston 10, the gas of the gas outlet end of the snorkel II 9
Body check valve is directly closed, and gas pressure increases, and the cooling gas check valve in snorkel I 8 is promoted unidirectionally to beat towards drug moiety 6
It opens, gas can enter drug moiety 6, and the pressure rise in drug moiety 6 squeezes out the solutions/gels in drug moiety 6, protects
Barrier solutions/gels smoothly spray, into nasal cavity.
(4) after being administered, piston 10 is unclamped, the check valve of the snorkel I 8 returns to initial closed state.Spring is made
Original state is recoiled to naturally with lower piston 10, and the gas extrusion cabin 4 that pressure reduces beats the one-way cock of snorkel II 9
It opens, gas enters gas extrusion cabin 4 via filter screen, maintains device pressure balance, prepares for administration next time.
(5) opening to be arranged on 3 side wall of dosing tank takes medicine window to take out used drug moiety 6.As needed into
Process is administered in row next time, or carries out the cleaning of device.
Apparatus of the present invention can reach different treatment, health purpose by the difference of drug moiety.The drug mould
Block includes being not limited to following functions:
(1) drug moiety based on physiology seawater is used to nasal irrigation, to improve environment in nasal cavity.
(2) module based on relieving mental strain and helping sleep class drug ensures the state of mind, the health of the army and the people.
(3) module of the drug based on glucocorticoid, for treating the diseases such as Chronic Obstructive Pulmonary Disease.
(4) module based on sterile saline, alcohol etc., for completing the disinfection of drug delivery device, intranasal wound.
(5) rehabilitation is promoted for improving the nervous function of Post stroke patient based on the drug moiety of nerve growth factor.
(6) based on the drug moiety of analgesic, for treating the chronic forms pain such as trigeminal neuralgia.
(7) drug moiety based on drugs such as Montelukast Sodium, beta receptor agonist classes, for treating allergic rhinitis, roaring
The air flues chronic inflammatory diseases such as asthma.
(8) based on the drug moiety of central stimulant, it is used to excited cerebral cortex, medullary respiratory center stimulant, promotes
Brain function is restored, and can be used for the rescue of patient and needed for wartime.
(9) based on the drug moiety of mesenchymal stem cell, to promote the neurological functional recovery of Post stroke patient.
Claims (10)
1. a kind of device of quantitative intranasal brain-targeted drug delivery, which is characterized in that the device includes spray head and bottle body, the spray head
It is connected or is removably mounted on the bottle body, dosing tank, gas extrusion cabin are respectively equipped in the bottle body and for putting
The accommodating cabin of drug moiety is set, is equipped with the partition that can be inserted into and extract, the accommodating between the dosing tank and accommodating cabin
Cartridge clip spline structure is additionally provided in cabin for pushing drug moiety to dosing tank, the dosing tank is connected to described by snorkel I
Gas extrusion cabin, the snorkel I is equipped with the cooling gas check valve opened towards dosing tank, and the gas extrusion cabin leads to
It crosses snorkel II and is connected to the external world, the outlet end of the snorkel II is equipped with the cooling gas check valve opened towards gas extrusion cabin, institute
It is equipped with piston in the gas extrusion cabin stated, spring, the spray are installed between the piston and the bulkhead in gas extrusion cabin
Delivery tube is equipped in head, the arrival end of the delivery tube is arranged in the dosing tank；
The drug moiety includes the drug reservoir equipped with drug of sealing, and the chamber wall of the drug reservoir is by hard material
It is made, and the position that the arrival end of the delivery tube and the gas outlet end of the snorkel I are corresponded on chamber wall is set as sealing
Membrane structure；
The gas outlet end of the arrival end of the delivery tube and the snorkel I is the tip made of hard material, convenient for thorn
Break the sealing state that the sealing membrane structure is inserted into the drug reservoir and guarantees drug reservoir.
2. the apparatus according to claim 1, which is characterized in that the gas of the arrival end of the delivery tube and the snorkel I
Body outlet end is located at the top of the dosing tank, and the sealing membrane structure includes seal pipe and for close encapsulation pipe
The film of upper end, the lower end of the seal pipe of the corresponding delivery tube arrival end are located at the bottom of the drug reservoir and are located at medical fluid
Liquid level under, the lower end of the seal pipe of corresponding I gas outlet end of snorkel is located at the top of the drug reservoir and is located at
On the liquid level of medical fluid.
3. the apparatus of claim 2, which is characterized in that the side wall of the dosing tank, which is equipped with, takes medicine window for taking out
Used drug moiety.
4. the apparatus according to claim 1, which is characterized in that be additionally provided with drug storage cabin, the drug storage in the bottle body
Cabin is equipped with hatchcover.
5. the apparatus according to claim 1, which is characterized in that the II gas access end of snorkel is equipped with strainer.
6. the apparatus according to claim 1, which is characterized in that the cartridge clip spline structure includes push plate and substrate, described
Push plate and substrate between spring is installed, the push plate is produced by the spring being mounted between the push plate and the substrate
Raw elastic force pushes drug moiety to dosing tank.
7. the apparatus according to claim 1, which is characterized in that one end insertion of the substrate is arranged in the accommodating cabin cabin
In groove on wall, the other end of the substrate is fixed using lock.
8. the apparatus according to claim 1, which is characterized in that the partition is inserted into institute by the jack being located on bulkhead
Between the dosing tank stated and accommodating cabin.
9. a kind of drug reservoir, which is characterized in that the chamber wall of the drug reservoir is made of hard material, and is also set on chamber wall
There are two seal membrane structure；The sealing membrane structure includes seal pipe and the film for close encapsulation pipe upper end,
In a seal pipe lower end be located at the drug reservoir bottom and be located at medical fluid liquid level under, the lower end of another seal pipe
It is located at the top of the drug reservoir and is located on the liquid level of medical fluid.
10. drug reservoir according to claim 9, which is characterized in that the upper end of the seal pipe is funnel-form, described
Film is arranged in hopper base.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811157385.7A CN109303970A (en) | 2018-09-30 | 2018-09-30 | A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811157385.7A CN109303970A (en) | 2018-09-30 | 2018-09-30 | A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery |
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| CN109303970A true CN109303970A (en) | 2019-02-05 |
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