CN109289107B - Device of ration intranasal brain target dosing - Google Patents
Device of ration intranasal brain target dosing Download PDFInfo
- Publication number
- CN109289107B CN109289107B CN201811218611.8A CN201811218611A CN109289107B CN 109289107 B CN109289107 B CN 109289107B CN 201811218611 A CN201811218611 A CN 201811218611A CN 109289107 B CN109289107 B CN 109289107B
- Authority
- CN
- China
- Prior art keywords
- drug
- medicine
- support frame
- storage container
- bottle body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02W—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT
- Y02W90/00—Enabling technologies or technologies with a potential or indirect contribution to greenhouse gas [GHG] emissions mitigation
- Y02W90/10—Bio-packaging, e.g. packing containers made from renewable resources or bio-plastics
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention discloses a quantitative transcranial targeted drug delivery device, which comprises a bottle body, a spray head detachably mounted at the upper end of the bottle body, a drug emission assembly and a drug fixing assembly for fixing a drug module, wherein the drug fixing assembly and the drug emission assembly are sequentially arranged in the bottle body from top to bottom. The device for quantitative transnasal brain targeted drug delivery has the advantages of simple structure, convenience in use, detachability and easiness in cleaning, separates the detachable device from the premixed drug, fills the premixed drug into a special drug storage container according to a common or recommended dose, and achieves the purposes of simple, efficient, quantitative and clean drug delivery through the combined use of the two.
Description
Technical Field
The invention belongs to the field of medical instruments, and particularly relates to a quantitative nasal-cerebral targeted drug delivery device.
Background
The blood brain barrier is a natural barrier between the systemic circulation and the central nervous system, and can play a role in barrier, prevent pathogenic microorganisms and harmful substances from entering the brain, and prevent a plurality of medicines from entering the central nervous system to play a role in treatment. The existing administration methods, such as transcranial in-situ injection, subarachnoid injection and the like, are difficult to be widely applied to clinical patients due to strong traumatism, high operation technical requirements and the like.
The terminal branch of the olfactory nerve is distributed in the olfactory mucosa, and its presence makes it possible for foreign substances to enter the brain via the olfactory nerve and its associated pathways, as one of 12 pairs of cranial nerves. In addition, the nasal cavity also has trigeminal nerve branches, and the nasal mucosa has widely distributed blood vessels and lymphatic vessels which can communicate with the intracranial space, so that the medicine can not only avoid the blood brain barrier when entering the brain through the nose, but also reduce the administration difficulty to the maximum extent.
Current nasal delivery devices are becoming increasingly sophisticated in terms of the dispersion, transport and distribution of drugs. From simple nasal cavity cleaning spray pots and nasal cavity spraying to application of ultrasonic atomization and osmotic pumps to nasal administration devices, the distribution of the medicine in the nasal cavity can achieve the purposes of wide distribution and uniform dispersion. However, most devices have deficiencies in drug storage.
The traditional direct nasal drip method uses the existing mixed or premixed medicine to directly drip the nose, and has the advantages that the dosage can be flexibly adjusted according to the requirements of a user, however, the medicine needs to be configured before the nose drip, the workload of medical staff is increased in clinical use, and the compliance of use is reduced by complicated operation for a patient.
The integrated design of intranasal medicine and device is commonly found in liquid spray, osmotic pump, ultrasonic atomization device etc. and it is convenient that it doses, and the medicine misce bene can effectively improve the treatment effect of intranasal dosing. And many devices do not have a part for preventing backflow and are directly communicated with the outside, so that the possibility of pollution and deterioration of the medicines is increased, and the use period of validity of the medicines is reduced. And the nasal cavity is a bacteria-containing environment, and the device is used for a long time to cause the risk of secondary infection. Moreover, most of the integrated devices are difficult to disassemble, so that the cleaning and nursing obstacles can cause pollution.
In order to solve the problems, the device of the invention separates the detachable device from the premixed medicine, fills the medicine into a special medicine storage container according to the common or recommended dose, and achieves the aims of simple, efficient, quantitative and clean administration by combining the two medicines.
Disclosure of Invention
The invention aims to provide a device for quantitative transcranial targeted drug delivery.
The purpose of the invention can be realized by adopting the following technical scheme:
a device for quantitative transnasal brain targeted drug delivery comprises a bottle body, a spray head detachably mounted at the upper end of the bottle body, a drug emission assembly and a drug fixing assembly for fixing a drug module, wherein the drug fixing assembly and the drug emission assembly are sequentially arranged in the bottle body from top to bottom;
a dosing channel is arranged in the spray head, a filter tip is installed at the upper end of the dosing channel, and the lower end of the dosing channel is in an inverted funnel shape;
the medicine fixing assembly comprises a support frame I, the support frame I is arranged at the upper part in the bottle body in a lifting mode through a spring, a circular through hole is formed in the support frame I, the medicine module is placed on the support frame I, and the bottom of the medicine module is aligned to the circular through hole;
the medicine launching assembly comprises a support frame II capable of sliding up and down in the bottle body, a cylinder is arranged on the support frame II, and the cylinder is arranged right below the circular through hole of the support frame I;
the medicine module be the sealed medicine storage container that is equipped with the medicine, the upper portion of storing up the medicine container be for falling the funnel form and with the funnel form that falls of passageway lower extreme cooperatees of dosing, the lateral wall of storing up the medicine container is made by hard material, and the bottom surface is for can sealing store up the medicine container and can be gliding bottom surface from top to bottom or have the elastic bottom surface of excelling in, the medicine exit end of storing up the medicine container adopts the film to seal.
As an optimal technical scheme, the support frame I on install the lift handle and be used for control the height of the fixed subassembly of medicine, the one end of lift handle links firmly on support frame I, the other end through set up slide control from top to bottom through the vertical spout on the lateral wall of bottle one side the lift of the fixed subassembly of medicine.
Preferably, one end of the spring is fixed on the lifting handle, and the other end of the spring is fixed on a fixing point at the upper end of the vertical sliding groove.
As a preferred technical scheme, a launching handle is mounted on the support frame II and used for pushing the medicine launching assembly to pressurize the medicine storage container and release the medicine. One end of the launching handle is fixedly connected to the support frame II, and the other end of the launching handle slides up and down through a vertical sliding groove formed in the side wall of the other side of the bottle body.
More preferably, the bottom surface of the drug storage container is sealed to the bottom of the drug storage container by a folded bellows, the bottom surface is sealed to the upper end of the bellows, and the lower end of the bellows is sealed to the bottom of the drug storage container. Before use, the corrugated pipe is in a folded state, the internal volume of the medicine storage container is maximized, when the medicine storage container is used, the launching handle is pushed upwards quickly to enable the medicine launching assembly to apply pressure to the bottom surface of the medicine storage container, the corrugated pipe is opened under a stressed condition, the bottom surface slides upwards quickly in the medicine storage container, the volume of the medicine storage container is reduced, and the pressure is increased instantly to break through a sealing film at the medicine outlet end to release medicines.
The side wall of the medicine storage container is made of hard materials, the bottom surface of the medicine storage container can be closed, the bottom surface of the medicine storage container can slide up and down or has high-strength elasticity, and the medicine outlet end of the medicine storage container is sealed by a thin film.
Preferably, the side wall of the medicine storage container is cylindrical. The upper part of the medicine storage container is in a shape of an inverted funnel. Further preferably, the bottom surface of the medicine storage container is sealed at the bottom of the medicine storage container through a folded corrugated pipe, the bottom surface is sealed at the upper end of the corrugated pipe, and the lower end of the corrugated pipe is hermetically connected at the bottom of the medicine storage container.
The invention has the beneficial effects that:
the device for quantitative transnasal brain targeted drug delivery has the advantages of simple structure, convenience in use, detachability and easiness in cleaning, separates the detachable device from the premixed drug, fills the premixed drug into a special drug storage container according to a common or recommended dose, and achieves the purposes of simple, efficient, quantitative and clean drug delivery through the combined use of the two.
Drawings
Fig. 1 is a front view of a device for quantitative nasal-brain targeted drug delivery.
Fig. 2 is a left side view of a device for quantitative naso-cerebral targeted drug delivery.
Fig. 3 is a right side view of a device for quantitative transcranial targeted drug delivery.
Fig. 4 is a block diagram of a device for quantitative transcranial targeted drug delivery.
Fig. 5 is a top view of a drug retention assembly.
Fig. 6 is a top view of the drug emitting assembly.
Fig. 7 is a structural view of the medicine storage container.
Detailed Description
As shown in fig. 1 to 7, a device for quantitative target drug delivery through the nose and brain comprises a bottle body 1, a spray head 2 detachably mounted at the upper end of the bottle body 1, a drug module 3, a drug emitting component 5 and a drug fixing component 4 for fixing the drug module 3, wherein the drug fixing component 4 and the drug emitting component 5 are sequentially arranged in the bottle body 1 from top to bottom;
a dosing channel 2-1 is arranged in the spray head 2, a filter tip 2-2 is mounted at the upper end of the dosing channel 2-1, and the lower end of the dosing channel 2-1 is in an inverted funnel shape;
the medicine fixing component 4 comprises a support frame I4-1, the support frame I4-1 is arranged at the upper part in the bottle body 1 in a lifting manner through a spring 4-2, and the spring 4-2 is used for controlling the height of the medicine fixing component 4 and assisting the fixing of the medicine fixing component 4 to prevent over-extension or over-bending. A circular through hole 4-3 is formed in the support frame I4-1, the medicine module 3 is placed on the support frame I4-1, and the bottom of the medicine module 3 is aligned to the circular through hole 4-3;
the lifting handle 4-4 is arranged on the support frame I4-1 and used for controlling the height of the medicine fixing component, one end of the lifting handle 4-4 is fixedly connected to the support frame I4-1, and the other end of the lifting handle 4-4 controls the lifting of the medicine fixing component 4 through up-and-down sliding of the vertical sliding groove 1-1 arranged on the side wall of one side of the bottle body 1.
Further preferably, one end of the spring 4-2 is fixed on the lifting handle 4-4, and the other end of the spring 4-2 is fixed on a fixed point at the upper end of the vertical chute 1-1.
The drug launching assembly 5 comprises a support frame II 5-1 capable of sliding up and down in the bottle body 1, a cylinder 5-2 is arranged on the support frame II 5-1, and the cylinder 5-2 is arranged right below a circular through hole 4-3 of the support frame I4-1;
and a launching handle 5-3 is arranged on the support frame II 5-1 and used for pushing the medicine launching assembly 5 to pressurize the medicine module 3 and release the medicine. One end of the launching handle 5-3 is fixedly connected to the support frame II 5-1, and the other end of the launching handle slides up and down through a vertical sliding groove 1-2 formed in the side wall of the other side of the bottle body 1.
In order to increase the strength of the support frame I4-1 and the support frame II 5-1, triangular reinforcing ribs 4-5 and 5-4 are respectively arranged on the bottom surfaces of the support frame I4-1 and the support frame II 5-1.
The medicine module 3 is a sealed medicine storage container 3-1 filled with medicines, the upper part of the medicine storage container is in an inverted funnel shape and is matched with the inverted funnel shape at the lower end of the medicine feeding channel, the side wall of the medicine storage container is made of hard materials, the bottom surface is a bottom surface 3-2 which can seal the medicine storage container and can slide up and down or has high elasticity, and the medicine outlet end of the medicine storage container is sealed by a film 3-3. As a preferable technical scheme, the bottom surface 3-2 of the medicine storage container 3-1 is sealed at the bottom of the medicine storage container 3-1 through a folded corrugated pipe 3-4. The bottom surface 3-2 is sealed at the upper end of the corrugated pipe 3-4, and the lower end of the corrugated pipe 3-4 is hermetically connected with the bottom of the medicine storage container 3-1. Before use, the corrugated pipe 3-4 is in a folded state, the internal volume of the medicine storage container 3-1 is maximized, when the medicine storage device is used, the launching handle 5-3 is pushed upwards rapidly to enable the medicine launching assembly to apply pressure to the bottom surface 3-2 of the medicine storage container 3-1, the corrugated pipe 3-4 is opened under the stress condition, the bottom surface 3-2 slides upwards rapidly in the medicine storage container 3-1, the internal volume of the medicine storage container 3-1 is reduced, and the pressure is increased instantly to break through a sealing film at the medicine outlet end to release the medicine.
The connection mode of the spray head 2 and the bottle body 1 is threaded connection or buckling connection.
The drug in the drug module 3 is generally 100-500 μ L, which is a suitable dose for one-time administration. When the medicine bottle is used, the spray head 2 is taken down, the medicine module 3 is placed from the opening at the upper end of the bottle body 1, the medicine module 3 is placed on the support frame I4-1, and the bottom of the medicine module 3 is aligned to the circular through hole 4-3 on the support frame I4-1; the spray head 2 is installed, and the upper end of the medicine module 3 is tightly attached to the lower end of the medicine feeding channel 2-1 in an inverted funnel-shaped structure under the tension of 4-2 of the spring. The emission handle 5-3 is pushed rapidly upwards to enable the cylinder 5-2 of the medicine emission assembly to penetrate through the circular through hole 4-3 in the support frame I4-1, pressure is applied to the bottom surface 3-2 of the medicine storage container 3-1, the corrugated pipe 3-4 stretches upwards under the stress condition, the bottom surface 3-2 of the medicine module 3 slides rapidly upwards in the medicine storage container 3-1, the volume in the medicine storage container 3-1 is reduced, the pressure is increased instantly, the medicine breaks through a sealing film at the medicine outlet end and is released through the medicine delivery channel 2-1 of the spray head 2, and the medicine enters nasal mucosa and the olfactory region in a spray mode to achieve target medicine delivery through the nose and the brain. The filter 2-2 installed at the upper end of the administration path 2-1 can disperse the sprayed liquid column or large liquid drops into small liquid drops to increase the distribution area and reduce the mucous membrane irritation.
Since the drug is destroyed by manual pressurization, the pressurization speed is relatively slow, and the drug is pre-filled, it is recommended that the drug module 3 stores the drug having good fluidity and stable properties.
A medicine storage container is characterized in that the side wall of the medicine storage container 3-1 is made of a hard material, the bottom surface of the medicine storage container is a bottom surface which can seal the medicine storage container and can slide up and down or a bottom surface 3-2 with high elasticity, and the medicine outlet end of the medicine storage container is sealed by a thin film 3-3. The side wall of the medicine storage container 3-1 is cylindrical. The upper part of the medicine storage container 3-1 is in an inverted funnel shape. The bottom surface 3-2 of the medicine storage container is sealed at the bottom of the medicine storage container 3-1 through a folded corrugated pipe 3-4, the bottom surface 3-2 is sealed at the upper end of the corrugated pipe 3-4, and the lower end of the corrugated pipe 3-4 is hermetically connected at the bottom of the medicine storage container 3-1.
The device for quantitative transnasal brain targeted drug delivery has the advantages of simple structure, convenience in use, detachability and easiness in cleaning, separates the detachable device from the premixed drug, fills the premixed drug into a special drug storage container according to a common or recommended dose, and achieves the purposes of simple, efficient, quantitative and clean drug delivery through the combined use of the two.
Claims (6)
1. A device for quantitative target drug delivery through nose and brain is characterized by comprising a bottle body, a spray head detachably mounted at the upper end of the bottle body, a drug emission assembly and a drug fixing assembly for fixing a drug module, wherein the drug fixing assembly and the drug emission assembly are sequentially arranged in the bottle body from top to bottom;
a drug delivery channel is arranged in the spray head, a filter tip is arranged at the upper end of the drug delivery channel, and the lower end of the drug delivery channel is in an inverted funnel shape;
the medicine fixing assembly comprises a support frame I, the support frame I is arranged at the upper part in the bottle body through a spring in a lifting manner, a circular through hole is formed in the support frame I, the medicine module is placed on the support frame I, and the bottom of the medicine module is aligned to the circular through hole;
the medicine launching assembly comprises a support frame II capable of sliding up and down in the bottle body, a cylinder is arranged on the support frame II, and the cylinder is arranged right below the circular through hole of the support frame I;
the medicine module be the sealed medicine storage container that is equipped with the medicine, the upper portion of storing up the medicine container be for falling the funnel form and with the funnel form that falls of passageway lower extreme cooperatees of dosing, the lateral wall of storing up the medicine container is made by hard material, and the bottom surface is for can sealing store up the medicine container and can be gliding bottom surface from top to bottom or have the elastic bottom surface of excelling in, the medicine exit end of storing up the medicine container adopts the film to seal.
2. The device for quantitative transnasal-cerebral targeted drug delivery according to claim 1, wherein the support frame I is provided with a lifting handle for controlling the height of the drug fixing component, one end of the lifting handle is fixedly connected to the support frame I, and the other end of the lifting handle controls the lifting of the drug fixing component by sliding up and down through a vertical sliding groove formed in the side wall of one side of the bottle body.
3. The device for quantitative transcranial targeted drug delivery according to claim 2, wherein one end of the spring is fixed on the lifting handle, and the other end of the spring is fixed on a fixed point at the upper end of the vertical chute.
4. The device for quantitative transnasal-cerebral targeted drug delivery according to claim 1, wherein a launching handle is mounted on the support II and used for pushing the drug launching assembly to pressurize the drug storage container and release the drug.
5. The device for quantitative transcranial targeted drug delivery according to claim 4, wherein one end of the emission handle is fixedly connected to the support frame II, and the other end of the emission handle slides up and down through a vertical sliding groove formed in the side wall of the other side of the bottle body.
6. The device for quantitative transnasal-cerebral-targeted drug delivery according to claim 1, wherein the bottom surface of the drug storage container is sealed at the bottom of the drug storage container by a folded bellows, the bottom surface is sealed at the upper end of the bellows, and the lower end of the bellows is hermetically connected at the bottom of the drug storage container.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811218611.8A CN109289107B (en) | 2018-10-19 | 2018-10-19 | Device of ration intranasal brain target dosing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811218611.8A CN109289107B (en) | 2018-10-19 | 2018-10-19 | Device of ration intranasal brain target dosing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109289107A CN109289107A (en) | 2019-02-01 |
| CN109289107B true CN109289107B (en) | 2023-03-17 |
Family
ID=65157766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811218611.8A Active CN109289107B (en) | 2018-10-19 | 2018-10-19 | Device of ration intranasal brain target dosing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109289107B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204446844U (en) * | 2015-03-03 | 2015-07-08 | 苏州同力生物医药有限公司 | Disposable per nasal brain-targeted drug delivery device |
| CN106983947A (en) * | 2017-05-10 | 2017-07-28 | 北京大学深圳医院 | Vaginal lactobacilli planter |
| WO2018072665A1 (en) * | 2016-10-17 | 2018-04-26 | 广东东阳光药业有限公司 | Multi-cavity atomizing apparatus |
| CN209332917U (en) * | 2018-10-19 | 2019-09-03 | 中国人民解放军南京军区南京总医院 | A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3184136T3 (en) * | 2010-03-25 | 2021-08-23 | New Injection Systems Ltd | INJECTOR |
| WO2016107789A1 (en) * | 2014-12-29 | 2016-07-07 | Novo Nordisk A/S | Drug delivery device with a hydraulic trigger mechanism |
-
2018
- 2018-10-19 CN CN201811218611.8A patent/CN109289107B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN204446844U (en) * | 2015-03-03 | 2015-07-08 | 苏州同力生物医药有限公司 | Disposable per nasal brain-targeted drug delivery device |
| WO2018072665A1 (en) * | 2016-10-17 | 2018-04-26 | 广东东阳光药业有限公司 | Multi-cavity atomizing apparatus |
| CN106983947A (en) * | 2017-05-10 | 2017-07-28 | 北京大学深圳医院 | Vaginal lactobacilli planter |
| CN209332917U (en) * | 2018-10-19 | 2019-09-03 | 中国人民解放军南京军区南京总医院 | A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109289107A (en) | 2019-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN209332917U (en) | A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery | |
| US20140236098A1 (en) | Intraocular Injection Device | |
| DE60329608D1 (en) | SPRAY FIT WITH DRIVE DEVICE TO HI | |
| US11400265B2 (en) | Methods and systems for bathing nose and sinus passages | |
| CN109289107B (en) | Device of ration intranasal brain target dosing | |
| CN106492335B (en) | A kind of Internal Medicine-Oncology drug delivery device | |
| CN209221218U (en) | Atomized medicine introducing device is used in a kind of nursing of ear-nose-throat department | |
| CN204864522U (en) | Tumour internal medicine device of dosing | |
| CN105963853B (en) | Medicament sprinkler | |
| CN209332983U (en) | A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery | |
| US20160250423A1 (en) | Device for delivery of an aerosol substance | |
| CN108578883A (en) | A kind of the cell transplantation pipe and its application method of via intranasal application administration | |
| CN210844937U (en) | Integrated cleaning drug administration sprayer | |
| US20200038594A1 (en) | Drug delivery system | |
| CN203749630U (en) | Medical disinfection device for stomatological department | |
| CN211751504U (en) | Miniature micro-dispensing-free infusion pump | |
| KR101398106B1 (en) | Handpiece | |
| CN208770588U (en) | A kind of chemical spraying device of ENT dept. oral cavity from dynamic pressure tongue | |
| CN202397644U (en) | Syringe for dairy cow disease treatment | |
| KR102686490B1 (en) | Insulin syringes | |
| CN209695991U (en) | One kind being conducive to Adding chemicals atomizer | |
| RU187055U1 (en) | The cutaneous device of the system of repeated subcutaneous administration of a solution of medicinal substances | |
| CN109303970A (en) | A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery | |
| CN204484953U (en) | A kind of obstructed lacrimal passage therapeutic apparatus | |
| WO2018006195A1 (en) | Healthcare system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |