CN209332917U - A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery - Google Patents
A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery Download PDFInfo
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- CN209332917U CN209332917U CN201821694859.7U CN201821694859U CN209332917U CN 209332917 U CN209332917 U CN 209332917U CN 201821694859 U CN201821694859 U CN 201821694859U CN 209332917 U CN209332917 U CN 209332917U
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- drug
- drug reservoir
- support frame
- reservoir
- quantitative
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Abstract
The utility model discloses the devices and drug reservoir of a kind of quantitative intranasal brain-targeted drug delivery, the device includes bottle body, the spray head for being removably mounted at the bottle body upper end, drug emitting module and the drug fixation kit for fixed drug module, and the drug fixation kit and drug emitting module are successively set on from top to bottom in the bottle body.The apparatus structure of the quantitative intranasal brain-targeted drug delivery of the utility model design is simple, it is easy to use, detachably, it is readily cleaned, utility model device separates detachable apparatus and premix drug, and be filled to drug in special drug reservoir according to common or recommended dose, achieve the purpose that simple, efficient, quantitative, cleaning is administered by being applied in combination for the two.
Description
Technical field
The utility model belongs to medical instruments field, and in particular to a kind of quantitatively device of intranasal brain-targeted drug delivery and drug storage
Container.
Background technique
Blood-brain barrier is one layer of natural barrier between body circulation and central nervous system, is playing barrier action,
While stopping pathogenic microorganism and harmful substance to enter brain, also counteract that many drugs enter central nervous system and play treatment work
With.Existing many medications, such as through cranium in-situ injection, through subarachnoid injection, because of traumatic strong, operating technology
It is required that the reasons such as height, it is difficult to be widely used in clinical patients.
The branched ending of olfactory nerve is distributed in olfactory mucosa, as one of 12 pairs of cranial nerves, exists so that external substance passes through
Olfactory nerve and its related pathways enter brain in the presence of possible.In addition, the distribution of nasal cavity Zhong Yiyou trigeminal neuralgia branch, and schneiderian membrance exists
Widely distributed blood vessel and lymphatic vessel can be linked up with encephalic, therefore drug intranasal enters brain and can avoid blood-brain barrier and maximum journey
Degree ground reduces administration difficulty.
Current nose administration device is ripe day by day in terms of the dispersion of drug, transmission and distribution.It is clear from simple nasal cavity
Watering can, nasal spray are washed, to the application of ultrasonic atomizatio, osmotic pumps on nose administration device, distribution of the drug in nasal cavity is
It can achieve widely distributed and finely dispersed purpose.However most device Shortcomings in terms of drug storage.
Traditional direct nasal drip is using existing mixed or premix the direct collunarium of drug, it is advantageous that can neatly basis
The demand of user adjusts dosage, however configuration drug is needed before collunarium, and the work of medical staff is increased in clinical use
Amount, and for patients, complicated operation reduces the compliance used.
The integrated design of intranasal drug and device is common in liquid spray, osmotic pumps, ultrasonic atomizing device etc., administration
Convenient, drug is uniformly mixed, and can effectively improve the therapeutic effect of nose administration.And the part of the not anti-backflow of many devices,
It is directly linked up with the external world, increases the rotten possibility of drug contamination, reduce drug uses validity period.And nasal cavity is to have collarium
Border, the device, which is used for a long time, the risk for causing secondary infection.And most integrated apparatus are difficult to dismantle, therefore clean the barrier of nursing
Hinder the generation for also resulting in pollution.
To solve the above problems, utility model device by detachable apparatus and premix drug separate, and by drug according to
Common or recommended dose is filled in special drug reservoir, reaches simple, efficient, quantitative, clear by being applied in combination for the two
The purpose of clean administration.
Summary of the invention
The purpose of this utility model is to provide the devices and drug reservoir of a kind of quantitative intranasal brain-targeted drug delivery.
The purpose of this utility model can be implemented with the following technical solutions:
A kind of device of quantitative intranasal brain-targeted drug delivery, the device include bottle body, are removably mounted at the bottle body upper end
Spray head, drug emitting module and the drug fixation kit for fixed drug module, the drug fixation kit and drug
Emitting module is successively set on from top to bottom in the bottle body；
The inside of the spray head is equipped with administration channel, and the upper end of the administration channel is equipped with filter tip, the administration channel
Lower end be inverted funnel shape；
The drug fixation kit includes support frame I, the support frame I by spring it is liftable be mounted on it is described
The intracorporal top of bottle, the support frame I are equipped with circular through hole, and the drug moiety is placed on support frame I, the medicine
Circular through hole described in the bottom alignment of object module；
The drug emitting module includes the support frame II that can be slided up and down in the bottle body, the support
Frame II is equipped with cylinder, and the cylinder is located at the underface of the circular through hole of support frame as described above I；
The drug moiety is the drug reservoir equipped with drug of sealing, and the top of the drug reservoir is inverted funnel shape
And matched with the inverted funnel shape of the administration channel lower end, the side wall of the drug reservoir is made of hard material, and bottom surface is
The drug reservoir can be closed and the bottom surface that can be slided up and down or the bottom surface with high-strength elastic, the medicine of the drug reservoir
Object outlet end is sealed using film.
As a kind of optimal technical scheme, lifting handle is installed solid for controlling the drug on the support frame I
Determine the height of component, one end of the lifting handle is connected on support frame I, and the other end is by being provided with bottle body side side
The vertical chute on wall slides up and down the lifting for controlling the drug fixation kit.
It is further preferred that one end of the spring is fixed on the lifting handle, the other end of the spring is solid
It is scheduled on the fixed point of the vertical chute upper end.
As a kind of optimal technical scheme, transmitting handle is installed for pushing the drug on the support frame II
Emitting module in the drug reservoir to pressurizeing and discharge drug.One end of the transmitting handle is connected in the support frame
On II, the other end is slided up and down by the vertical chute being provided on the side wall of the bottle body other side.
It is closer it is further preferred that the sylphon seal that folds of the underrun of the drug reservoir is in the drug reservoir
Bottom, in the upper end of the bellows, the lower end of the bellows is sealedly connected on the drug storage and holds the sealing bottom surface
The bottom of device.Before use, the bellows is in folded state, the internal volume of the drug reservoir is maximized, in use,
Quickly pushing up transmitting handle makes drug emitting module apply pressure to the bottom surface of the drug reservoir, and bellows is in stress
Under the conditions of open, the bottom surface quick upward sliding in drug reservoir reduces the drug reservoir inner volume, pressure wink
Between increase break through medicine outlet end sealing film release drug.
The side wall of a kind of drug reservoir, the drug reservoir is made of hard material, and bottom surface is that can close the drug storage to hold
Device and the bottom surface that can be slided up and down or the bottom surface with high-strength elastic, the medicine outlet end of the drug reservoir using film into
Row sealing.
Preferably, the side wall of the drug reservoir is tubular.The top of the drug reservoir is inverted funnel shape.It is further excellent
Choosing, in the bottom of the drug reservoir, the bottom surface is close for the sylphon seal that the underrun of the drug reservoir folds
It is enclosed in the upper end of the bellows, the lower end of the bellows is sealedly connected on the bottom of the drug reservoir.
The utility model has the beneficial effects that
The apparatus structure of the quantitative intranasal brain-targeted drug delivery of the utility model design is simple, easy to use, detachably, is easy to
Cleaning, utility model device separate detachable apparatus and premix drug, and drug is loaded according to common or recommended dose
To in special drug reservoir, achieve the purpose that simple, efficient, quantitative, cleaning is administered by being applied in combination for the two.
Detailed description of the invention
Fig. 1 is the front view of the device of quantitative intranasal brain-targeted drug delivery.
Fig. 2 is the left side view of the device of quantitative intranasal brain-targeted drug delivery.
Fig. 3 is the right side view of the device of quantitative intranasal brain-targeted drug delivery.
Fig. 4 is the structure chart of the device of quantitative intranasal brain-targeted drug delivery.
Fig. 5 is the top view of drug fixation kit.
Fig. 6 is the top view of drug emitting module.
Fig. 7 is the structure chart of drug reservoir.
Specific embodiment
As shown in Fig. 1 ~ 7, a kind of device of quantitative intranasal brain-targeted drug delivery, the device includes bottle body 1, is removably mounted at
Spray head 2, drug moiety 3, drug emitting module 5 and the drug fixation kit for fixed drug module 3 of 1 upper end of bottle body
4, the drug fixation kit 4 and drug emitting module 5 are successively set on from top to bottom in the bottle body 1；
The inside of the spray head 2 is equipped with administration channel 2-1, and the upper end of the administration channel 2-1 is equipped with filter tip 2-2, institute
The lower end for stating administration channel 2-1 is inverted funnel shape；
The drug fixation kit 4 includes I 4-1 of support frame, and I 4-1 of support frame is liftable by spring 4-2
It is mounted on the top in the bottle body 1, the spring 4-2 is used to control the height of drug fixation kit 4, and ancillary drug is solid
The fixation for determining component 4 prevents hyperextension or excessively in the wrong.I 4-1 of support frame is equipped with circular through hole 4-3, the drug moiety
3 are placed on I 4-1 of support frame, circular through hole 4-3 described in the bottom alignment of the drug moiety 3；
The height that lifting handle 4-4 is used to control the drug fixation kit, institute are installed on I 4-1 of support frame
The one end for stating lifting handle 4-4 is connected on I 4-1 of support frame, and the other end is perpendicular on the 1 side side wall of bottle body by being provided with
The lifting for controlling the drug fixation kit 4 is slided up and down to sliding slot 1-1.
It is further preferred that one end of the spring 4-2 is fixed on the lifting handle 4-4, the spring 4-2's
The other end is fixed on the fixed point of the upper end the vertical chute 1-1.
The drug emitting module 5 includes support frame II 5-1 that can be slided up and down in the bottle body 1, described
II 5-1 of support frame be equipped with cylinder 5-2, the cylinder 5-2 be located at the circular through hole 4-3 of I 4-1 of support frame as described above just under
Side；
Transmitting handle 5-3 is installed for pushing the drug emitting module 5 to described on II 5-1 of support frame
Drug moiety 3 pressurize and discharge drug.One end of the transmitting handle 5-3 is connected on II 5-1 of support frame, another
End is slided up and down by the vertical chute 1-2 being provided on 1 other side side wall of bottle body.
For the intensity for increasing by I 4-1 of support frame and II 5-1 of support frame, respectively in I 4-1 of support frame as described above
Reinforcing rib 4-5,5-4 of triangle are equipped with the bottom surface of II 5-1 of support frame.
The drug moiety 3 is the drug reservoir 3-1 equipped with drug of sealing, and the top of the drug reservoir is to fall to leak
Bucket-shaped and match with the inverted funnel shape of the administration channel lower end, the side wall of the drug reservoir is made of hard material, bottom
Face is that can close the drug reservoir and can slide up and down or the bottom surface 3-2 with high-strength elastic, the drug reservoir
Medicine outlet end is sealed using film 3-3.As a kind of optimal technical scheme, the bottom surface 3-2 of the drug reservoir 3-1 is logical
Cross the bottom that the bellows 3-4 folded is sealed in the drug reservoir 3-1.The bottom surface 3-2 is sealed in the bellows 3-4
Upper end, the lower end of the bellows 3-4 is sealedly connected on the bottom of the drug reservoir 3-1.Before use, the bellows
3-4 is in folded state, and the internal volume of the drug reservoir 3-1 maximizes, in use, quickly pushing up transmitting handle 5-
3 make drug emitting module apply pressure to the bottom surface 3-2 of the drug reservoir 3-1, and bellows 3-4 is beaten under stress condition
It opens, the bottom surface 3-2 quick upward sliding in drug reservoir 3-1, reduces the drug reservoir 3-1 inner volume, pressure
The sealing film release drug at medicine outlet end is broken through in moment increase.
The connection type of the spray head 2 and bottle body 1 is to be threadedly coupled or snap connection.
Drug in the drug moiety 3 is generally 100-500 μ L, is the optimal dose of single administration.In use, removing
Spray head 2 is put into drug moiety 3 from the opening of 1 upper end of bottle body, and the drug moiety 3 is placed on I 4-1 of support frame, and bottom
Portion is directed at the circular through hole 4-3 on I 4-1 of support frame as described above；Spray head 2 is installed, the upper end of the drug moiety 3 is in spring
It is that inverted funnel shape structure is tightly bonded with the lower end the administration channel 2-1 under the pulling force of 4-2.Quickly push up transmitting handle
5-3 makes the cylinder 5-2 of drug emitting module pass through the circular through hole 4-3 on I 4-1 of support frame, holds to the drug storage
The bottom surface 3-2 of device 3-1 applies pressure, and bellows 3-4 is pulled up under stress condition, and the bottom surface 3-2 of the drug moiety 3 exists
Quick upward sliding in drug reservoir 3-1 reduces the drug reservoir 3-1 inner volume, and pressure moment increases, and breaks through drug
The sealing film at medicine outlet end discharges drug by the administration channel 2-1 of spray head 2, so that drug is entered nasal cavity with Sprayable and glues
Intranasal brain-targeted drug delivery is realized in film and regio olfactoria.The filter tip 2-2 of the upper end installation of the administration channel 2-1 can by the fluid column of injection or
Big droplet distribution is droplet to increase distribution area and reduce mucosal irritation sense.
Since drug is destroyed by manual pressure, pressing speed is relatively slow, and drug is to be pre-charged with, therefore suggest drug mould
The storage drug that mobility is preferable and property is stable in block 3.
The side wall of a kind of drug reservoir, drug reservoir 3-1 is made of hard material, and bottom surface is that can close the storage
Medicine container and the bottom surface that can be slided up and down or bottom surface 3-2 with high-strength elastic, the medicine outlet end of the drug reservoir is adopted
It is sealed with film 3-3.The side wall of the drug reservoir 3-1 is tubular.The top of the drug reservoir 3-1 is inverted funnel
Shape.The bottom surface 3-2 of the drug reservoir is sealed in the bottom of the drug reservoir 3-1 by the bellows 3-4 folded, described
Bottom surface 3-2 is sealed in the upper end of the bellows 3-4, and the lower end of the bellows 3-4 is sealedly connected on the drug reservoir 3-1
Bottom.
The apparatus structure of the quantitative intranasal brain-targeted drug delivery of the utility model design is simple, easy to use, detachably, is easy to
Cleaning, utility model device separate detachable apparatus and premix drug, and drug is loaded according to common or recommended dose
To in special drug reservoir, achieve the purpose that simple, efficient, quantitative, cleaning is administered by being applied in combination for the two.
Claims (10)
1. a kind of device of quantitative intranasal brain-targeted drug delivery, which is characterized in that the device include bottle body, be removably mounted at it is described
Spray head, drug emitting module and the drug fixation kit for fixed drug module of bottle body upper end, the fixed group of the drug
Part and drug emitting module are successively set on from top to bottom in the bottle body；
The inside of the spray head is equipped with administration channel, and the upper end of the administration channel is equipped with filter tip, under the administration channel
End is inverted funnel shape；
The drug fixation kit includes support frame I, and the support frame I is mounted on the bottle body by the way that spring is liftable
Interior top, the support frame I are equipped with circular through hole, and the drug moiety is placed on support frame I, the drug mould
Circular through hole described in the bottom alignment of block；
The drug emitting module includes the support frame II that can be slided up and down in the bottle body, the support frame II
It is equipped with cylinder, the cylinder is located at the underface of the circular through hole of support frame as described above I；
The drug moiety is the drug reservoir equipped with drug of sealing, the top of the drug reservoir for inverted funnel shape and with
The inverted funnel shape of the administration channel lower end matches, and the side wall of the drug reservoir is made of hard material, and bottom surface is can
It closes the drug reservoir and the bottom surface that can be slided up and down or the bottom surface with high-strength elastic, the drug of the drug reservoir goes out
Mouth end is sealed using film.
2. the device of quantitative intranasal brain-targeted drug delivery according to claim 1, which is characterized in that on the support frame I
The height that lifting handle is used to control the drug fixation kit is installed, one end of the lifting handle is connected in support frame I
On, the other end slides up and down the control drug fixation kit by the vertical chute being provided on the side wall of the bottle body side
Lifting.
3. the device of quantitative intranasal brain-targeted drug delivery according to claim 2, which is characterized in that one end of the spring is solid
It is scheduled on the lifting handle, the other end of the spring is fixed on the fixed point of the vertical chute upper end.
4. the device of quantitative intranasal brain-targeted drug delivery according to claim 1, which is characterized in that on the support frame II
Transmitting handle is installed for pushing the drug emitting module to pressurizeing in the drug reservoir and discharge drug.
5. the device of quantitative intranasal brain-targeted drug delivery according to claim 4, which is characterized in that the one of the transmitting handle
End is connected on the support frame II, and the other end in the vertical chute that is provided on the side wall of the bottle body other side by gliding
It is dynamic.
6. the device of quantitative intranasal brain-targeted drug delivery according to claim 1, which is characterized in that the bottom of the drug reservoir
Face by the sylphon seal that folds in the bottom of the drug reservoir, the sealing bottom surface in the upper end of the bellows,
The lower end of the bellows is sealedly connected on the bottom of the drug reservoir.
7. a kind of drug reservoir, which is characterized in that the side wall of the drug reservoir is made of hard material, and bottom surface is can close institute
It states drug reservoir and the bottom surface that can be slided up and down or the bottom surface with high-strength elastic, the medicine outlet end of the drug reservoir is adopted
It is sealed with film.
8. drug reservoir according to claim 7, which is characterized in that the side wall of the drug reservoir is tubular.
9. drug reservoir according to claim 7 or 8, which is characterized in that the top of the drug reservoir is inverted funnel shape.
10. drug reservoir according to claim 7, which is characterized in that the wave that the underrun of the drug reservoir folds
The line seal of tube is in the bottom of the drug reservoir, and the sealing bottom surface is under the upper end of the bellows, the bellows
End is sealedly connected on the bottom of the drug reservoir.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821694859.7U CN209332917U (en) | 2018-10-19 | 2018-10-19 | A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821694859.7U CN209332917U (en) | 2018-10-19 | 2018-10-19 | A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209332917U true CN209332917U (en) | 2019-09-03 |
Family
ID=67745622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821694859.7U Withdrawn - After Issue CN209332917U (en) | 2018-10-19 | 2018-10-19 | A kind of device and drug reservoir of quantitative intranasal brain-targeted drug delivery |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209332917U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109289107A (en) * | 2018-10-19 | 2019-02-01 | 中国人民解放军南京军区南京总医院 | A kind of device of quantitative intranasal brain-targeted drug delivery |
| WO2024027040A1 (en) * | 2022-08-05 | 2024-02-08 | 王鹏 | Medicine canister with dispensing needle |
-
2018
- 2018-10-19 CN CN201821694859.7U patent/CN209332917U/en not_active Withdrawn - After Issue
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109289107A (en) * | 2018-10-19 | 2019-02-01 | 中国人民解放军南京军区南京总医院 | A kind of device of quantitative intranasal brain-targeted drug delivery |
| CN109289107B (en) * | 2018-10-19 | 2023-03-17 | 中国人民解放军南京军区南京总医院 | Device of ration intranasal brain target dosing |
| WO2024027040A1 (en) * | 2022-08-05 | 2024-02-08 | 王鹏 | Medicine canister with dispensing needle |
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| AV01 | Patent right actively abandoned |
Granted publication date: 20190903 Effective date of abandoning: 20230317 |
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| AV01 | Patent right actively abandoned |
Granted publication date: 20190903 Effective date of abandoning: 20230317 |
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| AV01 | Patent right actively abandoned | ||
| AV01 | Patent right actively abandoned |