CN109288060A - A kind of L MALIC ACID increases the health care product and preparation method thereof of bone density - Google Patents
A kind of L MALIC ACID increases the health care product and preparation method thereof of bone density Download PDFInfo
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- CN109288060A CN109288060A CN201811127909.8A CN201811127909A CN109288060A CN 109288060 A CN109288060 A CN 109288060A CN 201811127909 A CN201811127909 A CN 201811127909A CN 109288060 A CN109288060 A CN 109288060A
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- China
- Prior art keywords
- malic acid
- bone density
- health care
- preparation
- care product
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- 229940116298 l- malic acid Drugs 0.000 title claims abstract description 62
- 230000037182 bone density Effects 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 38
- 230000036541 health Effects 0.000 title claims abstract description 34
- 238000004519 manufacturing process Methods 0.000 title description 8
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 16
- 239000000284 extract Substances 0.000 claims abstract description 16
- 239000011782 vitamin Substances 0.000 claims abstract description 16
- 229940092124 calcium citrate malate Drugs 0.000 claims abstract description 13
- MPCMQXRREZMSPJ-UHFFFAOYSA-L calcium;2-hydroxybutanedioate;2-hydroxypropane-1,2,3-tricarboxylic acid;pentahydrate Chemical compound O.O.O.O.O.[Ca+2].[O-]C(=O)C(O)CC([O-])=O.OC(=O)CC(O)(C(O)=O)CC(O)=O MPCMQXRREZMSPJ-UHFFFAOYSA-L 0.000 claims abstract description 13
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 11
- 229940059329 chondroitin sulfate Drugs 0.000 claims abstract description 11
- 235000013343 vitamin Nutrition 0.000 claims abstract description 11
- 229940088594 vitamin Drugs 0.000 claims abstract description 11
- 229930003231 vitamin Natural products 0.000 claims abstract description 11
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 11
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical class OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 5
- CHVZQMAANSUXJU-JJKGCWMISA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanamide;hydrochloride Chemical compound Cl.NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CHVZQMAANSUXJU-JJKGCWMISA-N 0.000 claims abstract description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 claims description 15
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 13
- 239000003513 alkali Substances 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 11
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 6
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 6
- 238000009938 salting Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 3
- 239000002552 dosage form Substances 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 3
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 2
- 244000046146 Pueraria lobata Species 0.000 claims 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 241000219781 Pueraria montana var. lobata Species 0.000 abstract description 14
- 230000000694 effects Effects 0.000 abstract description 8
- BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract description 5
- 239000002253 acid Substances 0.000 abstract description 3
- 229940049920 malate Drugs 0.000 abstract description 3
- 206010067484 Adverse reaction Diseases 0.000 abstract description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract description 2
- 230000006838 adverse reaction Effects 0.000 abstract description 2
- 230000008901 benefit Effects 0.000 abstract description 2
- 238000011160 research Methods 0.000 abstract description 2
- 210000000988 bone and bone Anatomy 0.000 description 20
- 239000011575 calcium Substances 0.000 description 17
- 229910052791 calcium Inorganic materials 0.000 description 17
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 16
- 241000700159 Rattus Species 0.000 description 14
- 239000002904 solvent Substances 0.000 description 13
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical group [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
- 210000000689 upper leg Anatomy 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 6
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 5
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 5
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 5
- 229960002442 glucosamine Drugs 0.000 description 5
- 208000001132 Osteoporosis Diseases 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 239000004459 forage Substances 0.000 description 3
- 235000013402 health food Nutrition 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 235000006708 antioxidants Nutrition 0.000 description 2
- 230000002146 bilateral effect Effects 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000013376 functional food Nutrition 0.000 description 2
- 150000002301 glucosamine derivatives Chemical class 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 235000011181 potassium carbonates Nutrition 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 108091006149 Electron carriers Proteins 0.000 description 1
- 102000013460 Malate Dehydrogenase Human genes 0.000 description 1
- 108010026217 Malate Dehydrogenase Proteins 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- -1 alkali metal salt Chemical class 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000037118 bone strength Effects 0.000 description 1
- 150000001669 calcium Chemical class 0.000 description 1
- 229960005069 calcium Drugs 0.000 description 1
- 230000003185 calcium uptake Effects 0.000 description 1
- 239000003560 cancer drug Substances 0.000 description 1
- 230000005961 cardioprotection Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 230000003861 general physiology Effects 0.000 description 1
- 239000000852 hydrogen donor Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 238000009616 inductively coupled plasma Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940099690 malic acid Drugs 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 229940127554 medical product Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 229940105631 nembutal Drugs 0.000 description 1
- 238000009806 oophorectomy Methods 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- WPUMTJGUQUYPIV-UHFFFAOYSA-L sodium malate Chemical compound [Na+].[Na+].[O-]C(=O)C(O)CC([O-])=O WPUMTJGUQUYPIV-UHFFFAOYSA-L 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 235000012976 tarts Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A23L33/155—Vitamins A or D
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses the health care products and preparation method thereof that a kind of L MALIC ACID increases bone density.The health care product that this L MALIC ACID increases bone density is made of raw material below: aminoglucose hydrochloride, chondroitin sulfate, kudzu root extract, L MALIC ACID salt, calcium citrate malate, vitamin.Also disclose that this L MALIC ACID increases the preparation method of the health care product of bone density simultaneously.The present invention takes full advantage of the healthcare function of L MALIC ACID, by the preparation of L MALIC ACID salt, can apply on health care product.It cooperates with kudzu root extract, citrate malate acid to increase bone density by research discovery L MALIC ACID, improves the adverse reaction of previous product, and it is more significant to increase bone density effect.
Description
Technical field
The present invention relates to the health care products and preparation method thereof that a kind of L MALIC ACID increases bone density.
Background technique
Osteoporosis is that a kind of systemic bone amount and bone structure change, and increases with bone brittleness and is easy to cause fracture
Disease, with bone amount reduction in unit volume, the micro-architectural deterioration of bone, compact bone substance is thinning, bone trabecula number is reduced, ossis
Broadening, bone strength lowers, being easy to fracture is characterized.The whole world about 200,000,000 people suffer from osteoporosis, and it is each that disease incidence occupies the world
The 6th of kind common disease.China 60 years old or more old man 80% suffers from osteoporosis, and there are about patients with osteoporosis 60,000,000-
80000000, wherein with elderly woman disease incidence highest.
L MALIC ACID (L-malic acid, LMA) is the food additives that dosage arranges the 3rd after citric acid, lactic acid,
The acid and flavoring agent being mainly used as in beverage and food industry.L MALIC ACID can promote intracellular ATP to generate, and strengthen machine
The energetic supersession of body.It is important as organism to generate NAD (P) H, NAD (P) H for L MALIC ACID under the action of malic dehydrogenase
Electron carrier and hydrogen donor, participate in the reducing/regenerating of a variety of antioxidant, maintain the anti-oxidant energy of body, and can be with
Free radical is directly removed, antioxidation is played.L MALIC ACID also has enhancing calcium uptake, antifatigue, cardioprotection, reduction anti-
The physiological functions such as cancer drug toxic side effect can be applied in functional food and medical product.L MALIC ACID will play a role, and take the photograph
A certain amount must be reached by entering amount, but since mouthfeel is too sour, limit its application on functional food.L MALIC ACID salt tart flavour
Weaken, but is sold in the market without L-type malate.
The prior art has been widely used comprising Glucosamine, chondroitin sulfate, kudzu root extract, calcium, vitamine D3
Product for increasing bone density, such as ZL201210123708.7, provide one kind by Glucosamine, calcium agent and fish oil group
At have increase bone density and Saving cortilage double effects health food design scheme.ZL200910169811.3 is provided
It is a kind of that there is joint care and increasing by what Glucosamine, chondroitin sulfate, calcium agent, copper agent, manganese agent and vitamin formed
Add the health care product and preparation method thereof of bone density.
Summary of the invention
The purpose of the present invention is to provide the health care products and preparation method thereof that a kind of L MALIC ACID increases bone density.
The technical solution used in the present invention is:
A kind of L MALIC ACID increases the health care product of bone density, is made of the raw material of following mass parts: glucosamine salt
200 parts~500 parts of hydrochlorate, 100 parts~300 parts of chondroitin sulfate, 10 parts~60 parts of kudzu root extract, 8 parts of L MALIC ACID salt~
20 parts, 200 parts~500 parts of calcium citrate malate, 0.3 part~0.8 part of vitamin.
This L MALIC ACID increases in the health care product of bone density, and vitamin is vitamine D3.
This L MALIC ACID increases the preparation method of the health care product of bone density, comprising the following steps:
1) alkali carbonate or bicarbonate are made into salting liquid with water, are then reacted with L MALIC ACID mixing,
Mixture is obtained, is stood；
2) mixture is mixed with kudzu root extract, is pelletized, it is dry；
3) obtained dried object is mixed with calcium citrate malate, adds aminoglucose hydrochloride, chondroitin sulfate
Element and vitamin mixing, preparation, obtain the health care product that L MALIC ACID increases bone density.
In the step 1) of preparation method, in salting liquid the mass concentration of alkali carbonate or bicarbonate be 3%~
8%.
In the step 1) of preparation method, the molar ratio of L MALIC ACID and alkali carbonate or bicarbonate be 1:(0.5~
3)。
In the step 1) of preparation method, alkali carbonate or bicarbonate are specially sodium carbonate, potassium carbonate, bicarbonate
At least one of sodium, saleratus.
In the step 1) of preparation method, the time of standing is 15min~30min.
In the step 2) of preparation method, dry temperature is 45 DEG C~65 DEG C.
In the step 3) of preparation method, the dosage form of preparation is tablet, capsule, pulvis, any one in pill.
The beneficial effects of the present invention are:
The present invention takes full advantage of the healthcare function of L MALIC ACID, by the preparation of L MALIC ACID salt, can apply to
On health care product.It cooperates with kudzu root extract, citrate malate acid to increase bone density by research discovery L MALIC ACID, improves previous
The adverse reaction of product, and it is more significant to increase bone density effect.
Detailed description of the invention
Fig. 1 is the calcium content of bone figure of each test group of the present invention；
Fig. 2 is the midpoint bone density figure of each test group of the present invention；
Fig. 3 is the distal bone density map of each test group of the present invention.
Specific embodiment
A kind of L MALIC ACID increases the health care product of bone density, is made of the raw material of following mass parts: glucosamine salt
200 parts~500 parts of hydrochlorate, 100 parts~300 parts of chondroitin sulfate, 10 parts~60 parts of kudzu root extract, 8 parts of L MALIC ACID salt~
20 parts, 200 parts~500 parts of calcium citrate malate, 0.3 part~0.8 part of vitamin.
Preferably, this L MALIC ACID increases in the health care product of bone density, and vitamin is vitamine D3.
Preferably, this L MALIC ACID increases in the health care product of bone density, and L MALIC ACID salt is L MALIC ACID alkali metal salt；
Further, L MALIC ACID salt is L MALIC ACID sodium salt or L MALIC ACID sylvite.
This L MALIC ACID increases the preparation method of the health care product of bone density, comprising the following steps:
1) alkali carbonate or bicarbonate are made into salting liquid with water, are then reacted with L MALIC ACID mixing,
Mixture is obtained, is stood；
2) mixture is mixed with kudzu root extract, is pelletized, it is dry；
3) obtained dried object is mixed with calcium citrate malate, adds aminoglucose hydrochloride, chondroitin sulfate
Element and vitamin mixing, preparation, obtain the health care product that L MALIC ACID increases bone density.
Preferably, in the step 1) of preparation method, the mass concentration of alkali carbonate or bicarbonate is in salting liquid
3%~8%.
Preferably, in the step 1) of preparation method, the molar ratio of L MALIC ACID and alkali carbonate or bicarbonate is
1:(0.5~3).
Preferably, in the step 1) of preparation method, alkali carbonate or bicarbonate be specially sodium carbonate, potassium carbonate,
At least one of sodium bicarbonate, saleratus；It is further preferred that alkali carbonate or bicarbonate are specially bicarbonate
At least one of sodium, saleratus.
Preferably, in the step 1) of preparation method, the time of standing is 15min~30min.
Preferably, in the step 2) of preparation method, dry temperature is 45 DEG C~65 DEG C.
Preferably, in the step 3) of preparation method, the dosage form of preparation is tablet, capsule, pulvis, any one in pill
Kind.
The contents of the present invention are described in further detail below by way of specific embodiment.Original used in embodiment
Material unless otherwise specified, can be obtained from routine business approach.
Embodiment 1:
The L MALIC ACID of embodiment 1 increase bone density health care product the preparation method is as follows:
1) sodium bicarbonate 10.6g is accurately weighed, 150g water is added, sodium bicarbonate solution is made.L MALIC ACID is accurately weighed again
L MALIC ACID is added in solution by 13.4g, and side stirring while reacting, obtains mixture.
2) mixture is stood 20 minutes, kudzu root extract 60g is then added, pelletized, 60 DEG C of dryings are spare.
3) it weighs 300g calcium citrate malate to be added in dried object, mixes, add auxiliary material glucosamine hydrochloric acid
300 parts of salt, 200 parts of chondroitin sulfate and 0.5 part of vitamine D3 mixing, are made tablet.
Embodiment 2:
The L MALIC ACID of embodiment 2 increase bone density health care product the preparation method is as follows:
1) saleratus 12.6g is accurately weighed, 150g water is added, potassium bicarbonate solution is made.L MALIC ACID is accurately weighed again
L MALIC ACID is added in solution by 13.4g, and side stirring while reacting, obtains mixture.
2) mixture is stood 20 minutes, kudzu root extract 40g is then added, pelletized, 60 DEG C of dryings are spare.
3) it weighs 400g calcium citrate malate to be added in dried object, mixes, add auxiliary material glucosamine hydrochloric acid
400 parts of salt, 100 parts of chondroitin sulfate and 0.5 part of vitamine D3 mixing, are made tablet.
Evaluation test:
Be below by health caring food tablet made from embodiment 1 carry out functional evaluation test, and with L MALIC ACID is not added,
By the kudzu root extract and calcium citrate malate of identical weight ratio, tablet made of auxiliary material is added and compares.
1 test objective
Effect of the observation using this technique and the tablet of formula production to castrated rats bone density, in addition observes and L- is not added
Malic acid is added tablet made of auxiliary material and is carried out to castration by the kudzu root extract and calcium citrate malate of identical weight ratio
The effect of rat bone density, the two are compared, and determine that L MALIC ACID collaboration kudzu root extract, calcium citrate malate increase are gone
Gesture rat bone density.
2 given the test agent
Using the tablet material of the formula production of embodiment 1, character: brownish-yellow powder is named as sample 1；L- apple is not added
Auxiliary material is added by the kudzu root extract and calcium citrate malate of identical weight ratio in tartaric acid (weight occupied is by auxiliary material replacement)
Mixed raw material, character: brownish-yellow powder is named as sample 2.Storage method: cool place is dry, avoids direct sunlight, closed guarantor
It deposits.
3 experimental animals
SPF grades of SD kind Healthy female rats, 250~300g of weight are provided, animal by Guangdong Medical Lab Animal Center
Production licence number: SCXK (Guangdong) 2013-0002, certification of fitness number NO.44007200007451.Experimental animal use is permitted
It can the number of card: SYXK (Guangdong) 2013-0011.Feeding environment: 20~26 DEG C of temperature, humidity mobility scale 40%~70%.Feed by
Guangdong Medical Lab Animal Center provides.
4 key instruments
Bone mineral analyzer (SD-1000), inductively coupled plasma spectrometer (5100ICP-OES).
5 methods
" health food is examined and assessment technique specification " (version in the 2003) side promulgated by Ministry of Health of the People's Republic of China
Method operation.
6 dose designs
Experiment sets 9 groups: sham-operation group, solvent control group, calcium carbonate group and sample 1 is low, in sample 1,1 high three, sample
Dosage group, sample 2 is low, in sample 2,2 high three dosage groups of sample, basic, normal, high three dosage is respectively 0.66,1.32,
3.96g/kg.bw is equivalent to 5,10,30 times of human body recommended amounts, solvent control group Ca2+For 150mg/100g feed, calcium carbonate
Group dosage is 0.39g/kg.bw, identical as sample high dose group calcium level.
7 sample treatments
Given the test agent is mixed in feed, by 8% conversion of weight.0.41%, 0.82% and 2.46% is pressed respectively by sample
Low, middle and high dose groups tested material feed is made in product incorporation formula forage；Separately on the basis of formula forage, mixed by 0.34%
Enter calcium carbonate identical with sample high dose group calcium level, calcium carbonate group feed is made.Feed formula is matched referring to AIN93 feed
Side.
8 test methods
After 90 female rats adapt to observation three days in laboratory conditions, six dosage groups are randomly divided into, it is respectively false
Operation group, solvent control group, calcium carbonate group, sample 1 be low, in sample 1,1 high dose group of sample, sample 2 be low, in sample 2, sample
2 high dose groups, every group 10, sub-cage rearing.Give the feed for mixing various dose given the test agent to each dosage group animal respectively
Freely ingest；Solvent control group animal and sham-operation group animal give formula forage；Calcium carbonate group gives calcium carbonate feed.It is all
Rat carries out Bilateral oophorectomy through intraperitoneal injection nembutal solution (20mg/kg.bw) anesthesia, and postoperative muscle injects 20,000 U
Penicillin.The fat that 0.5g or so is only cut off behind sham-operation group opening abdominal cavity, retains bilateral ovaries.Each group, which is given, after operation is formulated
Feed.It freely ingests, drinks deionized water to avoid calcium is obtained from drinking-water.
9 observation index
9.1 ordinary circumstances: the general physiology sign of rat, appearance, behavior, stool and urine, fur etc..
9.2 growth and development: weight, food utilization etc..
9.3 femur weight: putting to death after animal feeding 3 months, separates right side femur, bakes in 105 DEG C of ovens to constant weight,
Weigh backbone weight.
9.4 bone densities: the bone density of left femur midpoint and distal end is measured with single photon bone density machine.
9.5 calcium content of bone: right side bone calcium content of femur is measured with inductance Coupled Plasma Spectroscopy instrument.
10 result judgements
Product not based on replenishing the calcium, solvent control group calcium content of bone or bone density are substantially less than sham-operation group, show to make
At the low model of rat bone density；The calcium content of bone or bone density of removal ovary dosage group are dramatically increased compared with solvent control group, and not
Lower than the calcium carbonate control group of corresponding dosage, and other indexs (except weight) are not significantly lower than solvent control group, can determine that by
Trying object has increase bone density function effect.
11 statistical dispositions
All data carry out variance analysis using SPSS13.0 software package, are as a result indicated with mean ± standard deviation
12 samples 1, influence of the sample 2 to rat body weight, food intake dose, utilization rate
As seen from Table 1: solvent control group rat body weight, total augment weight, total intake, overall utilization compared with sham-operation group,
In addition to starting weight no significant difference (P > 0.05), remaining has significant differences (P < 0.01)；Each dosage group indices
Compared with solvent control group, difference that there are no significant (P > 0.05) shows sample to nothings such as rat body weight, intake, utilization rates
It significantly affects.
1 technique of table and formula production tablet to rat body weight influence (n=10,)
13 samples 1, influence of the sample 2 to rat femur weight, calcium content of bone and bone density
As seen from Table 2: for solvent control group compared with sham-operation group, right side bone calcium content of femur, left femur distal bone are close
Degree significantly reduces, and difference is very significant (p < 0.01), shows to cause the low model of rat bone density.High dose group
Compared with solvent control group, right side bone calcium content of femur, left femur distal end bone density are dramatically increased, and difference has conspicuousness meaning
Adopted (p < 0.05)；And distal bone mean density value is greater than calcium carbonate group.Show that the given the test agent bone density test result is positive.This
Calcium content of bone, midpoint bone density, the distal bone density map for inventing each test group can be shown in attached drawing 1,2 and 3 respectively.
2 techniques of table and formula production tablet to femur weight, calcium content of bone and bone density influence (n=10,)
Note in table 2: 1.ΔΔIndicate solvent control group P < 0.01 compared with sham-operation group；2.**Indicate dosage group and solvent pair
Compare P < 0.01 according to group；*Indicate P < 0.05；3.#Indicate the p < 0.05 compared with sample 2 of sample 1.
14 conclusions
Originally the experimental results showed that, health food of the present invention, which has, increases bone density health function, and effect is better than not
The sample of L MALIC ACID is added, and there is significant difference.
Claims (9)
1. the health care product that a kind of L MALIC ACID increases bone density, it is characterised in that: be made of the raw material of following mass parts: amino Portugal
200 parts~500 parts of grape sugar hydrochloride, 100 parts~300 parts of chondroitin sulfate, 10 parts~60 parts of kudzu root extract, L MALIC ACID salt
8 parts~20 parts, 200 parts~500 parts of calcium citrate malate, 0.3 part~0.8 part of vitamin.
2. the health care product that a kind of L MALIC ACID according to claim 1 increases bone density, it is characterised in that: vitamin is dimension
Raw element D3.
3. the preparation method that a kind of L MALIC ACID increases the health care product of bone density, it is characterised in that: the following steps are included:
1) alkali carbonate or bicarbonate are made into salting liquid with water, then react, obtains with L MALIC ACID mixing
Mixture is stood；
2) mixture is mixed with kudzu root extract, is pelletized, it is dry；
3) obtained dried object is mixed with calcium citrate malate, add aminoglucose hydrochloride, chondroitin sulfate and
Vitamin mixing, preparation obtain the health care product of composition as claimed in claim 1 or 2.
4. the preparation method that a kind of L MALIC ACID according to claim 3 increases the health care product of bone density, it is characterised in that:
In step 1), the mass concentration of alkali carbonate or bicarbonate is 3%~8% in salting liquid.
5. the preparation method that a kind of L MALIC ACID according to claim 4 increases the health care product of bone density, it is characterised in that:
In step 1), L MALIC ACID is 1:(0.5~3 with the molar ratio of alkali carbonate or bicarbonate).
6. a kind of L MALIC ACID according to claim 4 or 5 increases the preparation method of the health care product of bone density, feature exists
In: in step 1), alkali carbonate or bicarbonate be specially sodium carbonate, potassium carbonate, sodium bicarbonate, in saleratus extremely
Few one kind.
7. the preparation method that a kind of L MALIC ACID according to claim 3 increases the health care product of bone density, it is characterised in that:
In step 1), the time of standing is 15min~30min.
8. the preparation method that a kind of L MALIC ACID according to claim 3 increases the health care product of bone density, it is characterised in that:
In step 2), dry temperature is 45 DEG C~65 DEG C.
9. the preparation method that a kind of L MALIC ACID according to claim 3 increases the health care product of bone density, it is characterised in that:
In step 3), the dosage form of preparation is tablet, capsule, pulvis, any one in pill.
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