CN109276732A - A kind of desinfection chamber sterilization method in medicine production process - Google Patents

A kind of desinfection chamber sterilization method in medicine production process Download PDF

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Publication number
CN109276732A
CN109276732A CN201811251560.9A CN201811251560A CN109276732A CN 109276732 A CN109276732 A CN 109276732A CN 201811251560 A CN201811251560 A CN 201811251560A CN 109276732 A CN109276732 A CN 109276732A
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CN
China
Prior art keywords
parts
production process
desinfection chamber
sterilization method
medicine production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201811251560.9A
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Chinese (zh)
Inventor
陈桂平
相解
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Nanjing Allen Chemical Technology Co Ltd
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Nanjing Allen Chemical Technology Co Ltd
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Publication date
Application filed by Nanjing Allen Chemical Technology Co Ltd filed Critical Nanjing Allen Chemical Technology Co Ltd
Priority to CN201811251560.9A priority Critical patent/CN109276732A/en
Publication of CN109276732A publication Critical patent/CN109276732A/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08—Magnoliopsida [dicotyledons]
    • A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultra-violet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/16—Disinfection, sterilisation or deodorisation of air using physical phenomena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/25—Rooms in buildings, passenger compartments

Abstract

The present invention provides the desinfection chamber sterilization method in a kind of medicine production process.Desinfection chamber sterilization method in medicine production process of the invention, it is characterized in that: this method comprises: (1) carries out ventilation ventilation process 1-2 hours to process(ing) cell daily；(2) at interval of progress spray disinfectant agent disinfection in 3-4 hours；(3) progress in every 12 hours ultraviolet lamp disinfection 15-30 minutes.The present invention is combined by the method for physics and chemistry, reaches more thorough aseptic processing environment, provides more structurally sound safety guarantee to drug production.

Description

A kind of desinfection chamber sterilization method in medicine production process
Technical field:
The present invention relates to the desinfection chamber sterilization methods in a kind of medicine production process, belong to chemical technology field.
Background technique:
Aseptic medicine quality is concerning patient vitals' safety, because drug is directly administered by injection or wound, although curative effect is fast Risk is larger.Therefore, the production of no aseptic medicine has to strictly design and carry out according to the method for verifying and regulation, it is sterile and Quality control must start from design, through production overall process.
There is no living microorganism in product to reach, aseptic medicine needs that various methods is taken to make a return journey in the fabrication process Except microorganism original in product and prevent pollution of the product by microorganism.It can be used to control microorganism there are many method Microorganism is killed or removes in growth, these methods are usually divided into chemically and physically two major classes in drug process for making. Wherein, chemical method has chemosterilant, gasification hydrogen peroxide, ozone and ethylene oxide etc.；Physical method has damp and hot or xeothermic goes out Bacterium, radiation sterilization and filtration sterilization etc..The reliability of these methods requires to prove using the test of the growth and breeding of microorganism.
Existing sterile working is mainly realized by the methods of ventilation, sterile clothes, and bacterial content can be substantially reached It is lower, it is unable to reach more thorough gnotobasis.
Summary of the invention:
The purpose of the present invention is providing the desinfection chamber sterilization method in a kind of medicine production process in view of the above problems, lead to The method for crossing physics and chemistry combines, and reaches more thorough aseptic processing environment, provides more structurally sound peace to drug production All risk insurance barrier.
Above-mentioned purpose is realized by following technical scheme:
Desinfection chamber sterilization method in medicine production process, this method comprises:
(1) ventilation ventilation process 1-2 hours is carried out to process(ing) cell daily；
(2) at interval of progress spray disinfectant agent disinfection in 3-4 hours；
(3) progress in every 12 hours ultraviolet lamp disinfection 15-30 minutes.
Desinfection chamber sterilization method in the medicine production process, the ventilation ventilation is carried out using purification air and nothing The indoor air exchange of bacterium.
Desinfection chamber sterilization method in the medicine production process, the disinfectant include honeysuckle in parts by weight 3-9 parts of extract, 2-5 parts of geranium oil, 4-9 parts of volatile argyi leaf oil, 5-8 parts of Rhzoma Atractylodis Lanceae volatile oil, 10-14 parts of hydrogen peroxide, to chlorine Meta-xylene phenol 5-12,50 parts of distilled water.
Desinfection chamber sterilization method in the medicine production process, the dosage of the spray disinfectant agent are 10-20ml/ Rice3Space.
Desinfection chamber sterilization method in the medicine production process, the dosage of the ultraviolet light irradiation are to ask radiation The intensity of 253.7nrn ultraviolet light are as follows: > 180uW/CM2。
The utility model has the advantages that
1. the present invention is combined by the method for physics and chemistry, reach more thorough aseptic processing environment, is mentioned to drug production For more structurally sound safety guarantee.
Specific embodiment:
Embodiment 1:
Desinfection chamber sterilization method in medicine production process, this method comprises:
(1) ventilation ventilation process 1-2 hours is carried out to process(ing) cell daily；
(2) at interval of progress spray disinfectant agent disinfection in 3-4 hours；
(3) progress in every 12 hours ultraviolet lamp disinfection 15-30 minutes.
Desinfection chamber sterilization method in the medicine production process, the ventilation ventilation is carried out using purification air and nothing The indoor air exchange of bacterium.
Desinfection chamber sterilization method in the medicine production process, the disinfectant include honeysuckle in parts by weight 3-9 parts of extract, 2-5 parts of geranium oil, 4-9 parts of volatile argyi leaf oil, 5-8 parts of Rhzoma Atractylodis Lanceae volatile oil, 10-14 parts of hydrogen peroxide, to chlorine Meta-xylene phenol 5-12,50 parts of distilled water.
Desinfection chamber sterilization method in the medicine production process, the dosage of the spray disinfectant agent are 10-20ml/ Rice3Space.
Desinfection chamber sterilization method in the medicine production process, the dosage of the ultraviolet light irradiation are to ask radiation The intensity of 253.7nrn ultraviolet light are as follows: > 180uW/CM2。
The above is only highly preferred embodiment of the present invention, the method for the present invention includes but be not limited to the above embodiments, the present invention Unaccomplished matter, belong to the common knowledge of those skilled in the art.

Claims (5)

1. the desinfection chamber sterilization method in a kind of medicine production process, it is characterized in that: this method comprises:
(1) ventilation ventilation process 1-2 hours is carried out to process(ing) cell daily；
(2) at interval of progress spray disinfectant agent disinfection in 3-4 hours；
(3) progress in every 12 hours ultraviolet lamp disinfection 15-30 minutes.
2. the desinfection chamber sterilization method in medicine production process according to claim 1, it is characterized in that: the ventilation is divulged information It is carried out and sterile indoor air exchange using purification air.
3. the desinfection chamber sterilization method in medicine production process according to claim 1, it is characterized in that: the disinfectant In parts by weight including Honegsukle flower P.E 3-9 parts, 2-5 parts of geranium oil, 4-9 parts of volatile argyi leaf oil, 5-8 parts of Rhzoma Atractylodis Lanceae volatile oil, 10-14 parts of hydrogen peroxide, parachlorometaxylenol 5-12,50 parts of distilled water.
4. the desinfection chamber sterilization method in medicine production process according to claim 1, it is characterized in that: the sprinkling disappears The dosage of toxic agent is 10-20ml/ meters3Space.
5. the desinfection chamber sterilization method in medicine production process according to claim 1, it is characterized in that: the ultraviolet lamp The dosage of irradiation is the intensity for seeking radiation 253.7nrn ultraviolet light are as follows: > 180uW/CM2。
CN201811251560.9A 2018-10-25 2018-10-25 A kind of desinfection chamber sterilization method in medicine production process Pending CN109276732A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201811251560.9A CN109276732A (en) 2018-10-25 2018-10-25 A kind of desinfection chamber sterilization method in medicine production process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201811251560.9A CN109276732A (en) 2018-10-25 2018-10-25 A kind of desinfection chamber sterilization method in medicine production process

Publications (1)

Publication Number Publication Date
CN109276732A true CN109276732A (en) 2019-01-29

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Family Applications (1)

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Country Status (1)

Country Link
CN (1) CN109276732A (en)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2064873U (en) * 1990-01-20 1990-10-31 王伟 Indoor air cleaner
WO2009046561A2 (en) * 2007-10-10 2009-04-16 Hanspeter Steffen Method for the disinfection of poultry barns and livestock sheds using ozone, electrolytically oxidative radicals, uv-c radiation, electrostatic spray technology, excess pressure ventilation and air-humidification technology
KR20110087516A (en) * 2010-01-26 2011-08-03 이용화 Hand sterilizer with self purifying function
CN102845482A (en) * 2012-08-14 2013-01-02 青岛叁鼎卫生制品有限公司 Air disinfectant with natural fragrance
CN106524384A (en) * 2016-11-14 2017-03-22 安徽名杰净化科技有限公司 Circular ventilation GMP sterile purification workshop
CN206167435U (en) * 2016-07-21 2017-05-17 四川康而好动物药业有限公司 A degassing unit for production of pharmaceuticals in -process
CN107198784A (en) * 2017-05-03 2017-09-26 安徽省伟业净化设备有限公司 A kind of I grades of clean operating room sterilization method
CN108246027A (en) * 2017-12-20 2018-07-06 佛山杰致信息科技有限公司 A kind of medicine production sterilizing dust removing room
CN108405018A (en) * 2018-06-07 2018-08-17 苏州朝霞生物科技有限公司 A kind of Bioexperiment aseptic operating platform

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN2064873U (en) * 1990-01-20 1990-10-31 王伟 Indoor air cleaner
WO2009046561A2 (en) * 2007-10-10 2009-04-16 Hanspeter Steffen Method for the disinfection of poultry barns and livestock sheds using ozone, electrolytically oxidative radicals, uv-c radiation, electrostatic spray technology, excess pressure ventilation and air-humidification technology
KR20110087516A (en) * 2010-01-26 2011-08-03 이용화 Hand sterilizer with self purifying function
CN102845482A (en) * 2012-08-14 2013-01-02 青岛叁鼎卫生制品有限公司 Air disinfectant with natural fragrance
CN206167435U (en) * 2016-07-21 2017-05-17 四川康而好动物药业有限公司 A degassing unit for production of pharmaceuticals in -process
CN106524384A (en) * 2016-11-14 2017-03-22 安徽名杰净化科技有限公司 Circular ventilation GMP sterile purification workshop
CN107198784A (en) * 2017-05-03 2017-09-26 安徽省伟业净化设备有限公司 A kind of I grades of clean operating room sterilization method
CN108246027A (en) * 2017-12-20 2018-07-06 佛山杰致信息科技有限公司 A kind of medicine production sterilizing dust removing room
CN108405018A (en) * 2018-06-07 2018-08-17 苏州朝霞生物科技有限公司 A kind of Bioexperiment aseptic operating platform

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
冯骏著: "《工业用水处理微生物分析》", 30 November 1989, 广东科技出版社 *
安欣良主编: "《血站（库）实用管理手册》", 31 August 1993, 苏州大学出版社 *

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Application publication date: 20190129

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