CN109276632A - A kind of Medical cold application and preparation method thereof - Google Patents

A kind of Medical cold application and preparation method thereof Download PDF

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Publication number
CN109276632A
CN109276632A CN201811327045.4A CN201811327045A CN109276632A CN 109276632 A CN109276632 A CN 109276632A CN 201811327045 A CN201811327045 A CN 201811327045A CN 109276632 A CN109276632 A CN 109276632A
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China
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parts
radix
medicine layer
medical cold
phase
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CN201811327045.4A
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Inventor
龙高产
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Henan Wufutang Trading Co Ltd
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Henan Wufutang Trading Co Ltd
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Priority to CN201811327045.4A priority Critical patent/CN109276632A/en
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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Abstract

The present invention relates to a kind of Medical cold applications and preparation method thereof, belong to technical field of Chinese medicine.The Medical cold application, including back sheet, medicine layer and adherent layer, medicine layer is made of traditional Chinese medicinal components and auxiliary material, and traditional Chinese medicinal components include: ground bettle, vomiting nut, Southern Star, the tuber of pinellia, Radix Notoginseng, safflower, asarum, Fructus Aurantii, green peel, pangolin, centipede, monkshood, radix aconiti agrestis, myrrh, Rhizoma Et Radix Notopterygii, Cortex Eucommiae, olibanum, Resina Draconis, Semen Cuscutae, red halloysite, full worm, Radix Glycyrrhizae, radix achyranthis bidentatae, Radix Polygalae, Radix Angelicae Sinensis, teasel root, tripterygium wilfordii, turtle shell, cortex cinnamomi；Auxiliary material includes: carbomer part, Sodium Polyacrylate part, glycerol part, purifying moisture content.Medical cold application of the present invention has effects that activating microcirculation and removing stasis medicinal, swelling and pain relieving, clearing damp eliminating impediment, the treatment for being mainly used for the closed soft tissue injuries such as various neck-shoulder pain, lumbago and leg pains, disc herniation, sciatica, rheumatic arthritis, traumatic injury and aching.

Description

A kind of Medical cold application and preparation method thereof
Technical field
The invention belongs to technical field of Chinese medicine, and in particular to a kind of Medical cold application and preparation method thereof.
Background technique
Cold compress patch is improved according to traditional cold compress mode, the drug delivery system prepared based on high-molecular gel For core, it is made of back sheet, gel layer, adherent layer.Cold compress patch can be such that local capillary shrinks, and mitigate contrafluxion, can Making the sensibility of nerve endings reduces and mitigates pain, and cooling is brought down a fever, and regional flow can be reduced, and prevents inflammation and diffusion of suppurating. Cold compress patch is mainly used for early stage local software tissue damage, hyperpyretic patient and heatstroke person, toothache etc. and needs cold compress crowd, function at present Can on certain limitation.China's tcm prescription flavour of a drug are mostly used as medicine with fine powder, and it is incomplete, quality controllable that there are drug releases The problems such as property is poor, inconvenient for use.
Summary of the invention
The purpose of the invention is to overcome the defect in conventional prescriptions dosage form, and break the function limitation of cold compress patch, and A kind of Medical cold application is provided, has effects that activating microcirculation and removing stasis medicinal, swelling and pain relieving, clearing damp eliminating impediment.
The object of the present invention is achieved like this: a kind of Medical cold application, including back sheet, medicine layer and adherent layer, institute It states medicine layer equably to apply on back sheet, the adherent layer is attached on medicine layer, it is characterised in that: under the medicine layer includes State the traditional Chinese medicinal components of mass fraction: 1-10 parts of ground bettle, 7-20 parts of vomiting nut, 1-10 parts of Southern Star, 5-15 parts of the tuber of pinellia, Radix Notoginseng 5-15 Part, 7-20 parts of safflower, 1-10 parts of asarum, 5-15 parts of Fructus Aurantii, 5-15 parts of green peel, 1-10 parts of pangolin, 5-15 parts of centipede, monkshood 7- 20 parts, 7-20 parts of radix aconiti agrestis, 5-15 parts of myrrh, 5-15 parts of Rhizoma Et Radix Notopterygii, 5-15 parts of Cortex Eucommiae, 7-14 parts of olibanum, 5-15 parts, Tu of Resina Draconis 5-15 parts sub-, 1-10 parts of red halloysite, worm 7-14 parts complete, 7-20 parts of Radix Glycyrrhizae, 5-15 parts of radix achyranthis bidentatae, 5-15 parts of Radix Polygalae, 5-15 parts of Radix Angelicae Sinensis, 7-14 parts of teasel root, 5-15 parts of tripterygium wilfordii, 7-14 parts of turtle shell, 15-25 parts of cortex cinnamomi；The medicine layer further includes following mass fractions Auxiliary material: 10-20 parts of carbomer, 15-25 parts of Sodium Polyacrylate, 60-120 parts of glycerol, 150-200 parts of purified water.
Further, a kind of medicine layer of the Medical cold application includes the traditional Chinese medicinal components of following mass fractions to the present invention: 5 parts of ground bettle, 10 parts of vomiting nut, 5 parts of Southern Star, 7 parts of the tuber of pinellia, 7 parts of Radix Notoginseng, 10 parts of safflower, 5 parts of asarum, 6 parts of Fructus Aurantii, green peel 6 Part, 5 parts of pangolin, 7 parts of centipede, 10 parts of monkshood, 10 parts of radix aconiti agrestis, 7 parts of myrrh, 6 parts of Rhizoma Et Radix Notopterygii, 6 parts of Cortex Eucommiae, 8 parts of olibanum, Resina Draconis 7 parts, 6 parts of Semen Cuscutae, 5 parts of red halloysite, 8 parts of full worm, 10 parts of Radix Glycyrrhizae, 7 parts of radix achyranthis bidentatae, 6 parts of Radix Polygalae, 6 parts of Radix Angelicae Sinensis, 8 parts of teasel root, Thunder God 7 parts of rattan, 8 parts of turtle shell, 20 parts of cortex cinnamomi；The medicine layer further includes the auxiliary material of following mass fractions: 15 parts of carbomer, polyacrylic acid 20 parts of sodium, 90 parts of glycerol, 170 parts of purified water.
A kind of preparation step of Medical cold application of the present invention is as follows:
1) Chinese medical concrete, is prepared
1., take ground bettle, vomiting nut, Southern Star, the tuber of pinellia, Radix Notoginseng, safflower, asarum, Fructus Aurantii, green peel, pangolin, centipede, monkshood, grass Crow, myrrh, Rhizoma Et Radix Notopterygii, Cortex Eucommiae, olibanum, Semen Cuscutae, red halloysite, full worm, Radix Glycyrrhizae, radix achyranthis bidentatae, Radix Polygalae, Radix Angelicae Sinensis, teasel root, tripterygium wilfordii, soft-shelled turtle First, cortex cinnamomi, grinding are in coarse powder；
2., take step 1. in coarse powder obtained, add 10 times amount volume fractions be 90% ethanol water, be heated to 78.5 DEG C, Reflux mentions 2-3 times, each 2-3h, combined extract, and being concentrated under reduced pressure into relative density is 1.15-1.20, obtains Chinese medical concrete, recycles Ethyl alcohol；
2) gel-type vehicle, is prepared
1. taking carbomer, it is dissolved in appropriate purified water, is sufficiently stirred, is swollen overnight, makees water phase A；
2. Sodium Polyacrylate, Resina Draconis powder is taken to be uniformly mixed, glycerol adding is stirred evenly, and makees glycerol phase B；
3. homemade traditional Chinese drug extract, as C phase；
4. A, A is added in B phase and stirs evenly after 60 DEG C of 10 min of water-bath by B phase, C phase is then added, stirs It mixes uniformly；
5. adjusting pH to neutrality to get gelling agent；
3), system patch
Gel investment is melted in glue tank, 80 DEG C is heated to, stirs 1 hour, is spread out by coating machine and applies molding, is pasted using cross cutting Piece is artificial compound to get molding Medical cold application.
In Chinese medicine composition of the present invention, each component pharmacological property drug effect is as described below.
Ground bettle-meridian distribution of property and flavor: it is cold, it is salty；Return liver warp；Mild toxicity；Major function: broken stasis of blood blood, continuous muscles and bones.It is rolled over for muscles and bones Wound, blood stasis closed, miasma lump in the abdomen lump in the abdomen.
Vomiting nut-meridian distribution of property and flavor: temperature, it is bitter；Return liver, the spleen channel；Big poison；Major function: remove obstruction in channels to relieve pain, mass dissipating and swelling eliminating.For Rheumatoid arthritis stubborn paralysis and numbness, injury from falling down, ulcer sore pain；Sequelae of infantile paralysis, rheumatoid arthritis.
Southern Star-meridian distribution of property and flavor: temperature, it is bitter, pungent；Return lung, liver, the spleen channel；Poison；Major function: eliminating dampness and eliminating phlegm, expelling wind and relieving convulsion, dissipates Knot detumescence.For stupid productive cough, anemophlegmatic vertigo, heap soil or fertilizer over and around the roots of apoplexy phlegm, facial paralysis, hemiplegia；Epilepsy, infantile convulsion, tetanus.It is raw to use Controlling outward carbuncle swells, snakebite and bugbite.
The tuber of pinellia-meridian distribution of property and flavor: temperature, it is pungent；Returns spleen, stomach, lung channel；Poison；Major function: eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, the ruffian that disappears dissipates Knot.For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, phlegm and headache, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus；It is raw with controlling outside Carbuncle swells subcutaneous nodule.Pinellia is chiefly used in stopping nausea and vomiting by lowering the adverse flow of QI.
Radix Notoginseng-meridian distribution of property and flavor: temperature, sweet, slight bitter；Return liver, stomach meridian；Major function: dissipating stasis and stanching bleeding, detumescence ding-tong.For coughing up Blood is spitted blood, bleeding from five sense organs or subcutaneous tissue, hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage, chest and abdomen shouting pain, tumbling and swelling.
Safflower-meridian distribution of property and flavor: temperature, it is pungent；Converge to heart and liver channels；Major function: blood circulation, removing blood stasis and acesodyne.For menostasis, pain Through, lochia, purplish or white patches on the skin lump in the abdomen lump in the abdomen, injury from falling down, sore swell and ache curative.
Asarum-meridian distribution of property and flavor: temperature, it is pungent；Return lung, kidney, the heart channel of Hang-Shaoyin；Mild toxicity；Major function: expelling wind and clearing away cold, sensible analgesic, warm lung Change drink.For anemofrigid cold, have a headache, toothache, nasosinusitis of having a stuffy nose, rheumatic arthralgia, sputum cough.
Fructus Aurantii-meridian distribution of property and flavor: temperature is bitter, pungent, sour；Returns spleen, stomach meridian；Major function: regulating the flow of QI to ease the stomach, the stagnant dissipate-swelling of row.For chest The stagnation of the circulation of vital energy, turgor pain are coerced, accumulation of food in the stomach and intes tine due to indigestion stops in phlegm retention；Gastroptosis, rectal prolapse, uterine prolapse.
Green peel-meridian distribution of property and flavor: temperature, it is pungent, bitter；Return liver, gallbladder, stomach meridian；Major function: soothing the liver relieving stagnant Qi, disperse accumulationization are stagnant.For chest Coerce distending pain, hernia, newborn core, acute mastitis, dyspeptic abdominalgia.
Pangolin-meridian distribution of property and flavor: it is slightly cold, it is salty；Return liver, stomach meridian；Major function: newborn under promoting menstruation, it is logical to search wind for detumescence and apocenosis Network.For menostasis lump in the abdomen lump in the abdomen, alactation, carbuncle sore tumefacting virus, arthralgia, numbness contracture.
Centipede-meridian distribution of property and flavor: temperature, it is pungent；Return liver warp；Poison；Major function: Inflammation Zhijing, dispersing pathogen accumulation are removed obstruction in channels to relieve pain.With In child convulsion, spasm of twitching, middle air port fish sticking its mouth out of the water, hemiplegia, cold, rheumatoid arthritis stubborn, sore, scrofula, venomous snake bite.
Monkshood-meridian distribution of property and flavor: heat, it is pungent, bitter；Return heart, spleen, liver and kidney channel；Big poison；Major function: dispelling wind and eliminating dampness, Wen Jingzhi Bitterly.It is used for treating arthralgia due to cold and dampness, arthralgia, trusted subordinate's crymodynia, cold hernia is had a pain, narcotic analgesic.
Radix aconiti agrestis-meridian distribution of property and flavor: heat, it is pungent, bitter；Return heart, liver,kidney,spleen warp；Big poison；Major function: dispelling wind and eliminating dampness, Wen Jingzhi Bitterly.It is used for treating arthralgia due to cold and dampness, arthralgia, trusted subordinate's crymodynia, cold hernia is had a pain, narcotic analgesic.
Myrrh-meridian distribution of property and flavor: it is flat, it is bitter, pungent；Return heart, liver, the spleen channel；Major function: promoting blood circulation and stopping pain, detumescence and promoting granulation.For outer Traumatology traumatic injury, sore carbuncle swells, all pain cards of stagnation of blood stasis.
Rhizoma Et Radix Notopterygii-meridian distribution of property and flavor: temperature, it is pungent, bitter；Return bladder, kidney channel；Major function: cold dispelling, wind-dispelling dehumidify, analgesic.For Anemofrigid cold headache, rheumatic arthralgia, aching pain in shoulder and back.
Cortex Eucommiae-meridian distribution of property and flavor: temperature, it is sweet；Return liver and kidney channel；Major function: nourishing liver and kidney, strengthening the bones and muscles, miscarriage prevention.For kidney deficiency waist Bitterly, muscles and bones is powerless, blood leaking in gestation, threatened abortion；Hypertension.
Olibanum-meridian distribution of property and flavor: temperature, it is pungent, bitter；Return liver, the heart, the spleen channel；Major function: blood-activating and qi-promoting relieves pain, detumescence and promoting granulation.With In external wounds traumatic injury, sore carbuncle swells, all pain cards of stagnation of blood stasis.
Semen Cuscutae-meridian distribution of property and flavor: temperature, it is sweet；Liver,kidney,spleen is returned to pass through；Major function: nourishing liver and kidney, miscarriage prevention, improving eyesight, antidiarrheal. For impotence and seminal emission, dripping urination, enuresis frequent micturition, soreness and weakness of waist and knees, blurred vision tinnitus, vaginal bleeding due to deficiency of the kidney during pregnancy, threatened abortion, spleen kidney deficiency rushes down； Externally treating leucoderma.
Red halloysite-meridian distribution of property and flavor: temperature, it is sweet, puckery；Return large intestine, stomach meridian；Major function: puckery intestines, hemostasis, myogenic sore.For Protracted dysentery and diarrhea, fecal blood, metrorrhagia and metrostaxis leukorrhagia；It controls sore outside not hold back, eczema pus contamination.
Full worm-meridian distribution of property and flavor: it is flat, it is pungent；Return liver warp；Poison；Major function: relieve the wind syndrome antispastic, dispersing pathogen accumulation are removed obstruction in channels to relieve pain.In Child convulsion, twitch spasm, middle air port fish sticking its mouth out of the water, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, sore, scrofula.
Radix Glycyrrhizae-meridian distribution of property and flavor: it is flat, it is sweet；Return heart, lung, spleen, stomach meridian；Major function: invigorating the spleen and benefiting qi, clearing heat and detoxicating, eliminating the phlegm stops Cough, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, fatigue and weakness, shortness of breath and palpitation, coughing with a lot of sputum, stomach duct and abdomen, four limbs contraction are suddenly ached Bitterly, carbuncle sore tumefacting virus alleviates drug toxicity, strong.
Radix achyranthis bidentatae-meridian distribution of property and flavor: it is flat, it is bitter, sweet, sour；Return liver and kidney channel；Major function: nourishing liver and kidney, strengthening the bones and muscles, dispelling stasis of blood and stimulating the menstrual flow, It ensurings proper downward flow of the blood.For soreness of waist and knee joint, muscles and bones is powerless, menostasis scar lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
Radix Polygalae-meridian distribution of property and flavor: temperature, it is bitter, pungent；Return heart, kidney, lung channel；Major function: tranquilize the mind and promote the intelligence, eliminating the phlegm, detumescence.For Insomnia and dreamful sleep caused by breakdown of the normal physiological coordination between the heart and the kidney, amnesia and pavor, despicable, expectoration is not well, sore swollen toxin, breast swell and pain.
Radix Angelicae Sinensis-meridian distribution of property and flavor: temperature, it is sweet, pungent；Return liver, the heart, the spleen channel；Major function: replenishing and activating blood, menstruction regulating and pain relieving, ease constipation are logical Just.For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, dry constipation of intestines, rheumatic arthralgia falls and flutters damage Wound, ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine blood circulation.For amenorrhea and algomenorrhea, rheumatic arthralgia, traumatic injury.
Teasel root-meridian distribution of property and flavor: tepor, it is bitter, sweet, pungent；Return liver and kidney channel；Major function: nourishing liver and kidney, strengthening the bones and muscles continue injured, Only metrorrhagia and metrostaxis.For soreness and weakness of waist and knees, rheumatic arthralgia, metrorrhagia and metrostaxis, vaginal bleeding during pregnancy, injury from falling down.
Tripterygium wilfordii-meridian distribution of property and flavor: it is cold, it is bitter；Converge to heart and liver channels；Big poison；Major function: dispelling wind and eliminating dampness, promoting blood circulation and removing obstruction in channels, detumescence Analgesic, desinsection removing toxic substances.It is used for treating arthralgia due to cold and dampness, furuncle swelling toxin, waistband sore, pruitus.
Turtle shell-meridian distribution of property and flavor: it is slightly cold, it is salty；Return liver and kidney channel；Major function: nourishing and suppressing Yang, resolving hard lump, bring down a fever except steaming. For fever due to yin deficiency, the hot hectic fever due to yin of labor, endogenous deficient wind, menostasis, chronic malaria malaria with abdominal mass.
Cortex cinnamomi-meridian distribution of property and flavor: big heat, it is pungent, sweet；Returns spleen, kidney, the heart, Liver Channel；Major function: mends fire supporing yang, let the fire back to its origin, Eliminating cold to stop pain, blood circulation.For impotence, palace cold, waist and knee crymodynia, kidney deficiency characterized by dyspnea, dizziness due to yang deficiency, hot eyes pharyngalgia, trusted subordinate's crymodynia, Cold of insufficiency type vomiting and diarrhea, cold hernia, renal mass, menostasis, dysmenorrhea.
Resina Draconis-also known as Sanguis Draxonis, for the red resin that swordleaf dragon tree trunk generates, property is sweet, warm, salty, flat, return heart, Liver Channel is enriched blood, the pharmacological effect of expelling pus and promoting granulation, referred to as " panacea of promoting blood circulation " with activating microcirculation and removing stasis medicinal, swelling and pain relieving, hemostasis, in Doctor is commonly used for promoting blood circulation to remove blood stasis and hemostatic.
The present invention overcomes the defect in traditional Chinese medicine prescription dosage form, and traditional Chinese medicine prescription is combined with gel ointment, system At a kind of Medical cold application with activating microcirculation and removing stasis medicinal, swelling and pain relieving.The present invention selects carbomer for carrier base material, card Wave nurse is that water-soluble base has preferable affinity to skin, nonirritant, without sensitization, can take off repeatedly and pull and stick, not dirty Contaminate clothing.Furthermore the present invention selects gelling agent to have drugloading rate big, and body absorbs fastly, and good permeability has good biofacies Capacitive, can long duration of action in affected part, medicament slow release effect can be played.Medical cold application of the present invention is mainly used for closed Pain caused by soft tissue injury, swelling and numbness treatment.The present invention, which has, practices Couple herbs for many years, is used for various neck shoulders Closed soft tissue injuries such as pain in waist and lower extremities, disc herniation, sciatica, rheumatic arthritis, traumatic injury and that aches control It treats, for cure rate up to 90%, patient feedback is good.
Specific embodiment
The present invention will be further explained with reference to the examples below.
Embodiment 1
A kind of Medical cold application, including back sheet, medicine layer and adherent layer, the medicine layer equably apply on back sheet, institute It states adherent layer to be attached on medicine layer, the medicine layer includes the traditional Chinese medicinal components of following mass fractions: 10 parts of ground bettle, vomiting nut 7 Part, 1 part of Southern Star, 5 parts of the tuber of pinellia, 5 parts of Radix Notoginseng, 20 parts of safflower, 10 parts of asarum, 15 parts of Fructus Aurantii, 5 parts of green peel, 10 parts of pangolin, centipede 15 parts, 7 parts of monkshood, 20 parts of radix aconiti agrestis, 15 parts of myrrh, 5 parts of Rhizoma Et Radix Notopterygii, 15 parts of Cortex Eucommiae, 7 parts of olibanum, 5 parts of Resina Draconis, 15 parts of Semen Cuscutae, 1 part of red halloysite, 14 parts of full worm, 20 parts of Radix Glycyrrhizae, 15 parts of radix achyranthis bidentatae, 5 parts of Radix Polygalae, 15 parts of Radix Angelicae Sinensis, 14 parts of teasel root, 15 parts of tripterygium wilfordii, soft-shelled turtle 14 parts of first, 25 parts of cortex cinnamomi；The medicine layer further includes the auxiliary material of following mass fractions: 20 parts of carbomer, 25 parts of Sodium Polyacrylate, 120 parts of glycerol, 200 parts of purified water.
The preparation step of the Medical cold application is as follows:
1) Chinese medical concrete, is prepared
1., take ground bettle, vomiting nut, Southern Star, the tuber of pinellia, Radix Notoginseng, safflower, asarum, Fructus Aurantii, green peel, pangolin, centipede, monkshood, grass Crow, myrrh, Rhizoma Et Radix Notopterygii, Cortex Eucommiae, olibanum, Semen Cuscutae, red halloysite, full worm, Radix Glycyrrhizae, radix achyranthis bidentatae, Radix Polygalae, Radix Angelicae Sinensis, teasel root, tripterygium wilfordii, soft-shelled turtle First, cortex cinnamomi, grinding are in coarse powder；
2., take step 1. in coarse powder obtained, add 10 times amount volume fractions be 90% ethanol water, be heated to 78.5 DEG C, Reflux mentions 2 times, each 3h, combined extract, and being concentrated under reduced pressure into relative density is 1.15, obtains Chinese medical concrete, recycles ethyl alcohol；
2) gel-type vehicle, is prepared
1. taking carbomer, it is dissolved in appropriate purified water, is sufficiently stirred, is swollen overnight, makees water phase A；
2. Sodium Polyacrylate, Resina Draconis powder is taken to be uniformly mixed, glycerol adding is stirred evenly, and makees glycerol phase B；
3. homemade traditional Chinese drug extract, as C phase；
4. A, A is added in B phase and stirs evenly after 60 DEG C of 10 min of water-bath by B phase, C phase is then added, stirs It mixes uniformly；
5. adjusting pH to neutrality to get gelling agent；
3), system patch
Gel investment is melted in glue tank, 80 DEG C is heated to, stirs 1 hour, is spread out by coating machine and applies molding, is pasted using cross cutting Piece is artificial compound to get molding Medical cold application.
Embodiment 2
A kind of Medical cold application, including back sheet, medicine layer and adherent layer, the medicine layer equably apply on back sheet, institute It states adherent layer to be attached on medicine layer, the medicine layer includes the traditional Chinese medicinal components of following mass fractions: 1 part of ground bettle, vomiting nut 20 Part, 10 parts of Southern Star, 15 parts of the tuber of pinellia, 15 parts of Radix Notoginseng, 20 parts of safflower, 10 parts of asarum, 5 parts of Fructus Aurantii, 15 parts of green peel, 1 part of pangolin, Wu 5 parts of centipede, 20 parts of monkshood, 7 parts of radix aconiti agrestis, 5 parts of myrrh, 15 parts of Rhizoma Et Radix Notopterygii, 5 parts of Cortex Eucommiae, 14 parts of olibanum, 15 parts of Resina Draconis, Semen Cuscutae 5 Part, 10 parts of red halloysite, 7 parts of full worm, 7 parts of Radix Glycyrrhizae, 5 parts of radix achyranthis bidentatae, 15 parts of Radix Polygalae, 5 parts of Radix Angelicae Sinensis, 7 parts of teasel root, 5 parts of tripterygium wilfordii, turtle shell 7 parts, 15 parts of cortex cinnamomi；The medicine layer further includes the auxiliary material of following mass fractions: 10 parts of carbomer, 15 parts of Sodium Polyacrylate, sweet 60 parts, 150 parts of purified water of oil.
The preparation step of the Medical cold application is as follows:
1) Chinese medical concrete, is prepared
1., take ground bettle, vomiting nut, Southern Star, the tuber of pinellia, Radix Notoginseng, safflower, asarum, Fructus Aurantii, green peel, pangolin, centipede, monkshood, grass Crow, myrrh, Rhizoma Et Radix Notopterygii, Cortex Eucommiae, olibanum, Semen Cuscutae, red halloysite, full worm, Radix Glycyrrhizae, radix achyranthis bidentatae, Radix Polygalae, Radix Angelicae Sinensis, teasel root, tripterygium wilfordii, soft-shelled turtle First, cortex cinnamomi, grinding are in coarse powder；
2., take step 1. in coarse powder obtained, add 10 times amount volume fractions be 90% ethanol water, be heated to 78.5 DEG C, Reflux mentions 3 times, each 2h, combined extract, and being concentrated under reduced pressure into relative density is 1.20, obtains Chinese medical concrete, recycles ethyl alcohol；
2) gel-type vehicle, is prepared
1. taking carbomer, it is dissolved in appropriate purified water, is sufficiently stirred, is swollen overnight, makees water phase A；
2. Sodium Polyacrylate, Resina Draconis powder is taken to be uniformly mixed, glycerol adding is stirred evenly, and makees glycerol phase B；
3. homemade traditional Chinese drug extract, as C phase；
4. A, A is added in B phase and stirs evenly after 60 DEG C of 10 min of water-bath by B phase, C phase is then added, stirs It mixes uniformly；
5. adjusting pH to neutrality to get gelling agent；
3), system patch
Gel investment is melted in glue tank, 80 DEG C is heated to, stirs 1 hour, is spread out by coating machine and applies molding, is pasted using cross cutting Piece is artificial compound to get molding Medical cold application.
Embodiment 3
Further, a kind of medicine layer of the Medical cold application includes the traditional Chinese medicinal components of following mass fractions to the present invention: ground beetle 5 parts of worm, 5 parts of Southern Star, 7 parts of the tuber of pinellia, 7 parts of Radix Notoginseng, 10 parts of safflower, 5 parts of asarum, 6 parts of Fructus Aurantii, 6 parts of green peel, is worn 10 parts of vomiting nut 5 parts of naze, 7 parts of centipede, 10 parts of monkshood, 10 parts of radix aconiti agrestis, 7 parts of myrrh, 6 parts of Rhizoma Et Radix Notopterygii, 6 parts of Cortex Eucommiae, 8 parts of olibanum, 7 parts of Resina Draconis, 6 parts of Semen Cuscutae, 5 parts of red halloysite, 8 parts of full worm, 10 parts of Radix Glycyrrhizae, 7 parts of radix achyranthis bidentatae, 6 parts of Radix Polygalae, 6 parts of Radix Angelicae Sinensis, 8 parts of teasel root, tripterygium wilfordii 7 Part, 8 parts of turtle shell, 20 parts of cortex cinnamomi；The medicine layer further includes the auxiliary material of following mass fractions: 15 parts of carbomer, Sodium Polyacrylate 20 parts, 90 parts of glycerol, 170 parts of purified water.
The preparation step of the Medical cold application is as follows:
1) Chinese medical concrete, is prepared
1., take ground bettle, vomiting nut, Southern Star, the tuber of pinellia, Radix Notoginseng, safflower, asarum, Fructus Aurantii, green peel, pangolin, centipede, monkshood, grass Crow, myrrh, Rhizoma Et Radix Notopterygii, Cortex Eucommiae, olibanum, Semen Cuscutae, red halloysite, full worm, Radix Glycyrrhizae, radix achyranthis bidentatae, Radix Polygalae, Radix Angelicae Sinensis, teasel root, tripterygium wilfordii, soft-shelled turtle First, cortex cinnamomi, grinding are in coarse powder；
2., take step 1. in coarse powder obtained, add 10 times amount volume fractions be 90% ethanol water, be heated to 78.5 DEG C, Reflux mentions 3 times, each 3h, combined extract, and being concentrated under reduced pressure into relative density is 1.18, obtains Chinese medical concrete, recycles ethyl alcohol；
2) gel-type vehicle, is prepared
1. taking carbomer, it is dissolved in appropriate purified water, is sufficiently stirred, is swollen overnight, makees water phase A；
2. Sodium Polyacrylate, Resina Draconis powder is taken to be uniformly mixed, glycerol adding is stirred evenly, and makees glycerol phase B；
3. homemade traditional Chinese drug extract, as C phase；
4. A, A is added in B phase and stirs evenly after 60 DEG C of 10 min of water-bath by B phase, C phase is then added, stirs It mixes uniformly；
5. adjusting pH to neutrality to get gelling agent；
3), system patch
Gel investment is melted in glue tank, 80 DEG C is heated to, stirs 1 hour, is spread out by coating machine and applies molding, is pasted using cross cutting Piece is artificial compound to get molding Medical cold application.
Specific embodiment is to further explanation of the invention rather than limits, and is existed for those of ordinary skills Further transformation is done in the case where not departing from substantive content of the present invention, and all these transformation all should belong to right appended by the present invention It is required that protection scope.
Application method of the present invention
By pain caused by closed soft tissue injury, swelling, numbness position, cleaning dry after, will be of the present invention medical Cold compress patch is pasted on affected part, and every note sticks for 24 hours, 5 one courses for the treatment of of patch.
Typical case
1, Zhang, male, 62 years old, patient's cervical pain was aching and tired about 1 year uncomfortable with double upper limb numbness, January was aggravated, in other doctor It does not feel any better after institute and clinic treatment, aggravation, later here treatment advises patient continuously to stick Medical-use cold compress of the present invention Three courses for the treatment of, the aching and tired substantially all disappearance of the pain numbness of call-on back by phone patient's neck are pasted, patient restores normal.
2, Zhao, male, 50 years old, patient's waist pain gave oral drugs through clinic and hospital with double lower limb pain numbness And pain relieving ointment treatment is sticked, it does not feel any better, under the introduction through others, patient carrys out here treatment, after telling about the state of an illness by patient, gives Giving needs 5 courses for the treatment of of patient to stick Medical cold application therapy of the present invention, and patient feedback's state of an illness restores good, and patient's waist is extensive Multiple, function is normal.
3, Chen, female, 55 years old, patient caused double knee joint pain, swelling, joint motion is limited, about because long-time is worked Half a year, patient is by the extraction of hospital's arthroedema, oral drugs and sticks analgesic plaster treatment, and symptom is not felt any better, later Here is medical, by patient clinical symptom and sign situation, advises patient to stick Medical cold of the present invention and applies 3 courses for the treatment of, and 24 Hour replacement is primary, and patient feedback's arthroedema inflammation fades away, and double knee joint can reach normal function.
4, Mr. Wang, male, 65 years old, patient went downstairs and slips accidentally, sprained ankle, and when patient assessment, ankle portion is red and swollen and companion There is pain, advises patient continuously to stick Medical cold of the present invention and apply two courses for the treatment of, call-on back by phone patient's ankle portion symptom is whole It disappears, patient restores normal.
5, Song, male, 61 years old, patient's waist pain was involved to lower limb pain more than half a year, and daily routines are slight firstly, coming me Punishment is treated, and according to patient clinical symptom and sign situation, giving, which needs 3 courses for the treatment of of patient to stick Medical cold application of the present invention, is controlled It treats, patient feedback's state of an illness restores good, and patient's waist pain disappears, and function is normal.
6, Zhang, female, 68 years old, patient the year before without obvious inducement start right side gonalgia with swelling, stretching and beading it is unfavorable, Limitation of activity, pain aggravates when walking and squatting down, and many places treatment is not felt any better, and later here is medical, by observing patient clinical Symptom and sign situation advise patient to stick Medical cold of the present invention and apply 5 courses for the treatment of, and replacement in 24 hours is primary, patient feedback Right side knee joint symptom fades away, and can reach normal function.

Claims (3)

1. a kind of Medical cold application, including back sheet, medicine layer and adherent layer, the medicine layer equably apply on back sheet, The adherent layer is attached on medicine layer, it is characterised in that: the medicine layer includes the traditional Chinese medicinal components of following mass fractions: ground bettle 1-10 parts, 7-20 parts of vomiting nut, 1-10 parts of Southern Star, 5-15 parts of the tuber of pinellia, 5-15 parts of Radix Notoginseng, 7-20 parts of safflower, 1-10 parts of asarum, trifoliate orange 5-15 parts of shell, 5-15 parts of green peel, 1-10 parts of pangolin, 5-15 parts of centipede, 7-20 parts of monkshood, 7-20 parts of radix aconiti agrestis, 5-15 parts of myrrh, 5-15 parts of Rhizoma Et Radix Notopterygii, 5-15 parts of Cortex Eucommiae, 7-14 parts of olibanum, 5-15 parts of Resina Draconis, 5-15 parts of Semen Cuscutae, 1-10 parts of red halloysite, full worm 7-14 parts, 7-20 parts of Radix Glycyrrhizae, 5-15 parts of radix achyranthis bidentatae, 5-15 parts of Radix Polygalae, 5-15 parts of Radix Angelicae Sinensis, 7-14 parts of teasel root, 5-15 parts of tripterygium wilfordii, soft-shelled turtle 7-14 parts of first, 15-25 parts of cortex cinnamomi；The medicine layer further includes the auxiliary material of following mass fractions: 10-20 parts of carbomer, polypropylene Sour sodium 15-25 parts, 60-120 parts of glycerol, 150-200 parts of purified water.
2. a kind of Medical cold application according to claim 1, it is characterised in that: a kind of medicine layer of Medical cold application Traditional Chinese medicinal components including following mass fractions: 5 parts of ground bettle, 10 parts of vomiting nut, 5 parts of Southern Star, 7 parts of the tuber of pinellia, 7 parts of Radix Notoginseng, safflower 10 parts, 5 parts of asarum, 6 parts of Fructus Aurantii, 6 parts of green peel, 5 parts of pangolin, 7 parts of centipede, 10 parts of monkshood, 10 parts of radix aconiti agrestis, 7 parts of myrrh, Rhizoma Et Radix Notopterygii 6 parts, it is 6 parts of Cortex Eucommiae, 8 parts of olibanum, 7 parts of Resina Draconis, 6 parts of Semen Cuscutae, 5 parts of red halloysite, 8 parts of full worm, 10 parts of Radix Glycyrrhizae, 7 parts of radix achyranthis bidentatae, remote 6 parts of will, 6 parts of Radix Angelicae Sinensis, 8 parts of teasel root, 7 parts of tripterygium wilfordii, 8 parts of turtle shell, 20 parts of cortex cinnamomi；The medicine layer further includes following mass fractions Auxiliary material: 15 parts of carbomer, 20 parts of Sodium Polyacrylate, 90 parts of glycerol, 170 parts of purified water.
3. a kind of a kind of preparation method of Medical cold application as claimed in claim 1 or 2, which is characterized in that including walking as follows It is rapid:
1) Chinese medical concrete, is prepared
1., take ground bettle, vomiting nut, Southern Star, the tuber of pinellia, Radix Notoginseng, safflower, asarum, Fructus Aurantii, green peel, pangolin, centipede, monkshood, grass Crow, myrrh, Rhizoma Et Radix Notopterygii, Cortex Eucommiae, olibanum, Semen Cuscutae, red halloysite, full worm, Radix Glycyrrhizae, radix achyranthis bidentatae, Radix Polygalae, Radix Angelicae Sinensis, teasel root, tripterygium wilfordii, soft-shelled turtle First, cortex cinnamomi, grinding are in coarse powder；
2., take step 1. in coarse powder obtained, add 10 times amount volume fractions be 90% ethanol water, be heated to 78.5 DEG C, Reflux mentions 2-3 times, each 2-3h, combined extract, and being concentrated under reduced pressure into relative density is 1.15-1.20, obtains Chinese medical concrete, recycles Ethyl alcohol；
2) gel-type vehicle, is prepared
1. taking carbomer, it is dissolved in appropriate purified water, is sufficiently stirred, is swollen overnight, makees water phase A；
2. Sodium Polyacrylate, Resina Draconis powder is taken to be uniformly mixed, glycerol adding is stirred evenly, and makees glycerol phase B；
3. homemade traditional Chinese drug extract, as C phase；
4. A, A is added in B phase and stirs evenly after 60 DEG C of 10 min of water-bath by B phase, C phase is then added, stirs It mixes uniformly；
5. adjusting pH to neutrality to get gelling agent；
3), system patch
Gel investment is melted in glue tank, 80 DEG C is heated to, stirs 1 hour, is spread out by coating machine and applies molding, is pasted using cross cutting Piece is artificial compound to get molding Medical cold application.
CN201811327045.4A 2018-11-08 2018-11-08 A kind of Medical cold application and preparation method thereof Pending CN109276632A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109674862A (en) * 2019-02-28 2019-04-26 山东朱氏药业集团有限公司 A kind of cold compress dressing and preparation method thereof and the dressing patch containing the cold compress dressing
CN111920888A (en) * 2020-08-05 2020-11-13 亳州益智健康产业有限公司 Medical cold compress patch and preparation method thereof
CN111991451A (en) * 2020-09-23 2020-11-27 哈药集团技术中心 Gel paste for promoting blood circulation to remove blood stasis and preparation method thereof

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Publication number Priority date Publication date Assignee Title
US20050058730A1 (en) * 2003-09-15 2005-03-17 Xushan Wan Compositions and methods for preventing or treating eyestrain
CN105709021A (en) * 2016-03-14 2016-06-29 张春荣 Muscle and bone recovery unguent and preparation method thereof
CN107693688A (en) * 2017-09-14 2018-02-16 江苏七0七天然制药有限公司 A kind of Chinese medicine patcher for treating arthralgia and myalgia and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050058730A1 (en) * 2003-09-15 2005-03-17 Xushan Wan Compositions and methods for preventing or treating eyestrain
CN105709021A (en) * 2016-03-14 2016-06-29 张春荣 Muscle and bone recovery unguent and preparation method thereof
CN107693688A (en) * 2017-09-14 2018-02-16 江苏七0七天然制药有限公司 A kind of Chinese medicine patcher for treating arthralgia and myalgia and preparation method thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109674862A (en) * 2019-02-28 2019-04-26 山东朱氏药业集团有限公司 A kind of cold compress dressing and preparation method thereof and the dressing patch containing the cold compress dressing
CN111920888A (en) * 2020-08-05 2020-11-13 亳州益智健康产业有限公司 Medical cold compress patch and preparation method thereof
CN111991451A (en) * 2020-09-23 2020-11-27 哈药集团技术中心 Gel paste for promoting blood circulation to remove blood stasis and preparation method thereof

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Application publication date: 20190129