CN109265533B - 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 - Google Patents
一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 Download PDFInfo
- Publication number
- CN109265533B CN109265533B CN201811279943.7A CN201811279943A CN109265533B CN 109265533 B CN109265533 B CN 109265533B CN 201811279943 A CN201811279943 A CN 201811279943A CN 109265533 B CN109265533 B CN 109265533B
- Authority
- CN
- China
- Prior art keywords
- polypeptide
- tumor
- peptide
- application
- inhibitory
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (3)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811279943.7A CN109265533B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN202010539216.0A CN111647065B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN202010539207.1A CN111548407B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN202010539210.3A CN111647064B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN202010539221.1A CN111548408B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811279943.7A CN109265533B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
Related Child Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010539207.1A Division CN111548407B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN202010539210.3A Division CN111647064B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN202010539221.1A Division CN111548408B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN202010539216.0A Division CN111647065B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN109265533A CN109265533A (zh) | 2019-01-25 |
CN109265533B true CN109265533B (zh) | 2020-11-17 |
Family
ID=65190911
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010539210.3A Expired - Fee Related CN111647064B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN201811279943.7A Active CN109265533B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN202010539207.1A Active CN111548407B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN202010539221.1A Active CN111548408B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN202010539216.0A Active CN111647065B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010539210.3A Expired - Fee Related CN111647064B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010539207.1A Active CN111548407B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN202010539221.1A Active CN111548408B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
CN202010539216.0A Active CN111647065B (zh) | 2018-10-30 | 2018-10-30 | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 |
Country Status (1)
Country | Link |
---|---|
CN (5) | CN111647064B (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113945723B (zh) * | 2021-10-28 | 2024-03-12 | 复旦大学附属中山医院 | 预测免疫检查点抑制剂治疗相关肺炎发生风险的系统、储存介质及其应用 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107383174A (zh) * | 2017-08-21 | 2017-11-24 | 苏州立豪生物科技有限公司 | 一种能与pd‑1特异性结合的肿瘤抑制肽及其用途 |
EP3333184A1 (en) * | 2016-12-09 | 2018-06-13 | Virogin Biotech Canada Ltd | Compositions and methods for inhibiting cd279 interactions |
CN108623671A (zh) * | 2018-06-17 | 2018-10-09 | 李兴国 | 一种抗肿瘤多肽及其血液检测抗体和试剂盒 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2717895A1 (en) * | 2011-06-08 | 2014-04-16 | Aurigene Discovery Technologies Limited | Therapeutic compounds for immunomodulation |
US9593115B2 (en) * | 2012-09-21 | 2017-03-14 | Advinus Therapeutics Ltd. | Substituted fused tricyclic compounds, compositions, and medicinal applications thereof |
US9308236B2 (en) * | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
US10570204B2 (en) * | 2013-09-26 | 2020-02-25 | The Medical College Of Wisconsin, Inc. | Methods for treating hematologic cancers |
CN104098651B (zh) * | 2014-06-30 | 2016-06-29 | 郑州大学 | 具有抗肿瘤活性的PD-L1 IgV亲和肽及其应用 |
WO2017200796A1 (en) * | 2016-05-17 | 2017-11-23 | Albert Einstein College Of Medicine, Inc. | Engineered pd-1 variants |
JP6928083B2 (ja) * | 2016-09-15 | 2021-09-01 | レイドス, インコーポレイテッド | Pd−1ペプチド阻害剤 |
CN108409830B (zh) * | 2018-02-05 | 2021-04-23 | 郑州大学 | 一种人pd-1蛋白胞外段亲和环肽c8及其应用 |
-
2018
- 2018-10-30 CN CN202010539210.3A patent/CN111647064B/zh not_active Expired - Fee Related
- 2018-10-30 CN CN201811279943.7A patent/CN109265533B/zh active Active
- 2018-10-30 CN CN202010539207.1A patent/CN111548407B/zh active Active
- 2018-10-30 CN CN202010539221.1A patent/CN111548408B/zh active Active
- 2018-10-30 CN CN202010539216.0A patent/CN111647065B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3333184A1 (en) * | 2016-12-09 | 2018-06-13 | Virogin Biotech Canada Ltd | Compositions and methods for inhibiting cd279 interactions |
CN107383174A (zh) * | 2017-08-21 | 2017-11-24 | 苏州立豪生物科技有限公司 | 一种能与pd‑1特异性结合的肿瘤抑制肽及其用途 |
CN108623671A (zh) * | 2018-06-17 | 2018-10-09 | 李兴国 | 一种抗肿瘤多肽及其血液检测抗体和试剂盒 |
Also Published As
Publication number | Publication date |
---|---|
CN111647065A (zh) | 2020-09-11 |
CN111548407A (zh) | 2020-08-18 |
CN111548407B (zh) | 2021-09-14 |
CN111548408B (zh) | 2021-08-03 |
CN111647064B (zh) | 2021-08-03 |
CN111647065B (zh) | 2021-10-08 |
CN111647064A (zh) | 2020-09-11 |
CN111548408A (zh) | 2020-08-18 |
CN109265533A (zh) | 2019-01-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5680661B2 (ja) | Il−2に由来する免疫調節ポリペプチド並びに癌及び慢性感染症の治療におけるその使用 | |
Lupu et al. | Characterization of a growth factor that binds exclusively to the erbB-2 receptor and induces cellular responses. | |
CN107383174B (zh) | 一种能与pd-1特异性结合的肿瘤抑制肽及其用途 | |
CN112386678B (zh) | 多肽或其衍生物的应用 | |
CN109265533B (zh) | 一种改进的能与pd-1特异性结合的肿瘤抑制肽及其用途 | |
CN109627340B (zh) | Cd3和prlr双特异性抗体及其构建与应用 | |
Chen et al. | Engineering a high-affinity PD-1 peptide for optimized immune cell-mediated tumor therapy | |
US20190307849A1 (en) | Methods of using interleukin-10 for treating diseases and disorders | |
CN113214406A (zh) | 一种结合gpc3融合蛋白的制备方法及应用 | |
EP4293039A1 (en) | Novel human interleukin-18 variant and use therefor | |
CN113105554B (zh) | 一种抗肿瘤融合蛋白及其制法和应用 | |
CN115850387A (zh) | 超高亲和力的靶向pd-l1的小蛋白及药物组合物 | |
KR101426134B1 (ko) | 항 igf-1r 단일클론 항체와 il-2를 포함하는 융합 단일클론 항체 및 이를 포함하는 암치료용 조성물 | |
KR20120052942A (ko) | 넓은 스펙트럼 erbb 리간드 결합 분자 및 이들을 제조하고 이용하는 방법 | |
US20150118228A1 (en) | Broad spectrum erbb ligand binding molecules and methods for their use | |
AU2014243836B2 (en) | Compositions and methods for treating cancer | |
WO2024037322A1 (zh) | 一种IL-15突变体-Fc/IL-15Rα亚基-Fc异源二聚体及其用途 | |
KR102386849B1 (ko) | 면역치료를 위한 환경 반응형 접착성 항체전달체 및 이의 제조방법 | |
WO2022247923A1 (en) | A super-trail molecule comprising two trail trimers | |
US20230416326A1 (en) | Modified interleukin-2 (il-2) molecule and use thereof | |
CN118240093A (zh) | 一种靶向her2与egfr的三特异性t细胞衔接器及其应用 | |
WO2023076927A1 (en) | Il-2 fusion proteins, pharmaceutical compositions, and therapeutic applications | |
Korman et al. | TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM | |
CN114099424A (zh) | 一种重组免疫细胞因子的制剂 | |
JP2015137247A (ja) | ポリペプチド及び抗腫瘍剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information | ||
CB03 | Change of inventor or designer information |
Inventor after: Wang Taihua Inventor after: Shi Xinyi Inventor after: Wang Zhen Inventor after: Zhang Yong Inventor before: Wang Zhen Inventor before: Zhang Yong |
|
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20201021 Address after: Room 401, 4 / F, building 10, innovation and Technology Park, Songshan Lake high tech Industrial Development Zone, Dongguan City, Guangdong Province 523808 Applicant after: Guangdong cel Biotechnology Co., Ltd Address before: Wuzhong District Mudu town Kiama street in Suzhou city in Jiangsu province 215000 No. 88 Applicant before: SUZHOU LIHAO BIOTECHNOLOGY Co.,Ltd. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20210426 Address after: 250101 room 510, 5th floor, scientific research and production building, 2766 Yingxiu Road, high tech Zone, Jinan City, Shandong Province Patentee after: SHANDONG NEW MEDICINE RESEARCH INSTITUTE OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE LLC Address before: Room 401, 4 / F, building 10, innovation and Technology Park, Songshan Lake high tech Industrial Development Zone, Dongguan City, Guangdong Province 523808 Patentee before: Guangdong cel Biotechnology Co., Ltd |