CN109260045A - 一种含类菌孢素-甘氨酸的自防腐保湿精华液 - Google Patents

一种含类菌孢素-甘氨酸的自防腐保湿精华液 Download PDF

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CN109260045A
CN109260045A CN201811207261.5A CN201811207261A CN109260045A CN 109260045 A CN109260045 A CN 109260045A CN 201811207261 A CN201811207261 A CN 201811207261A CN 109260045 A CN109260045 A CN 109260045A
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glycine
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林学镁
洪盛杰
赵文忠
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LAF INTERNATIONAL GROUP Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
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    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52Stabilizers
    • A61K2800/524Preservatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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Abstract

本发明属日化领域,具体涉及一种含类菌孢素‑甘氨酸的自防腐保湿精华液。该精华液除了包含有3.3%‑19.3%的常见保湿成份外,还含有1.4%‑3.0%的具有自防腐功效的成份:葡萄柚籽提取物、乳酸杆菌发酵产物以及艾叶提取物,本发明特别添加0.01%‑2.0%的类菌孢素‑甘氨酸。本发明加入了类菌孢素‑甘氨酸,能够提高皮肤含水量,具有增强保湿的功效。

Description

一种含类菌孢素-甘氨酸的自防腐保湿精华液
技术领域
本发明属于日化领域,具体涉及一种含类菌孢素-甘氨酸的自防腐保湿精华液。
背景技术
水对正常皮肤尤其是角质层的功能是非常重要的,其关键功能是参加正常脱屑所需的许多水解过程。当角质层水含量降到临界水平以下,正常脱屑所需酶的功能将受损,使得角化细胞粘附堆积在皮肤表面,导致了皮肤干燥、粗糙、脱屑,皮肤屏障功能受损,因此,皮肤保湿显得尤为重要,对于普通人来说,使用保湿护肤品是个比较好的选择。
保湿成分种类繁多,消费者也更青睐于来源于自然的活性成分。类菌孢素氨基酸是一类以环己烯酮或环己烯亚胺为特征,结合N取代氨基酸的小分子,众多研究集中在该类分子的吸收紫外线性质,将其作为新型防晒剂用于化妆品中,但未见研究其保湿性质。本专利所添加类菌孢素-甘氨酸来源于海洋生物,有研究表明该分子具有优越的脂质抗氧化功效,具有潜在应用于抗衰老产品,类菌孢素-甘氨酸分子结构含有多个羟基,并且含有氨基酸结构部分,但未见将其作为保湿成分进行研究,因此本发明将其应用于保湿精华液,探索其保湿功效。
发明内容
本发明的目的是提供一种含类菌孢素-甘氨酸的自防腐保湿精华液。
本发明的目的是这样实现的:
一种含类菌孢素-甘氨酸的自防腐保湿精华液,除含有精华液可接受的一般成份外,还含有:
占精华液重量3.3%-19.3%的保湿成份,该保湿成份为占精华液重量1.0%-3.0%的甜菜碱、占精华液重量0.5%-1.0%的吡咯烷酮羧酸钠、占精华液重量1.0%-10%的库拉索芦荟叶水、占精华液重量0.5%-5.0%的仙人掌提取物以及0.3%透明质酸钠的组合;
占精华液重量0.01%-0.1%的谷胱甘肽;
占精华液重量0.1%的尿囊素;
占精华液重量0.4%-0.7%的增稠剂汉生胶;
占精华液重量1.4%-3.0%的具有自防腐作用的成份,该自防腐成份为0.1%-0.5%的葡萄柚籽提取物、0.8%-1.5%的乳酸杆菌发酵产物以及0.5%-1.0%的艾叶提取物的组合;
占精华液重量0.01%-2.0%的类菌孢素-甘氨酸,分子结构如下:
本发明的保湿精华液,其特征在于组份及其含量重量百分比分别为:
本发明的有益效果
本发明在配方中添加了多种保湿成份,并特别添加类菌孢素-甘氨酸。经MoistureMeter测试表明,类菌孢素-甘氨酸的加入能够提高皮肤含水量,并维持3个小时,随着类菌孢素-甘氨酸加入百分比增加,皮肤含水量增加。另外,本配方采用来源于天然的成份,起自防腐作用,经防腐挑战测试,符合《化妆品安全技术规范2015版》要求。
附图说明
图1为8名志愿者使用含不同百分比类菌孢素-甘氨酸的保湿精华液后,皮肤相对含水量随时间的变化。
具体实施方式
下面结合实施例对本发明作进一步详述。
实施例I-V
以实施例I为例,其制作步骤如下:
1、将4g黄原胶分散在30.0g1,3-丙二醇中,待用;
2、把0.5gEDTA-2Na、1.0g尿囊素、30.0g甘油、10.0g甜菜碱、5.0g吡咯烷酮羧酸钠加入到779.5g去离子水中,加热到80℃,搅拌至溶解、分散充分,搅拌下逐渐加入黄原胶的丙二醇分散液;
3、降温到50℃,加入1.0g透明质酸钠、10.0g仙人掌提取物、100.0g库拉索芦荟叶水、0.5g谷胱甘肽、5.0g类菌孢素-甘氨酸、5.0g葡萄柚籽提取物、10.0g乳酸杆菌发酵产物、8.0g艾叶提取物;
4、降温到45℃,加入0.5g香精,搅拌均匀、降至室温后真空脱气。
本发明使用效果测试
挑选八名志愿者,处于恒温恒湿室内,1h后,左臂画出5个直径约为20mm的圆形区域,一个空白作为参考(Ref),另外四个分别涂含类菌孢素-甘氨酸不同重量百分数(0%、0.5%、1.0%和1.5%)的精华液样品。应用样品前,用MoistureMeter测5个区域皮肤含水量数值,平行测三次,取平均值。在测试区域涂上0.1g样品,1h后轻轻擦除样品,测试读数,再过1h、2h再测试读数。涂抹样品后测试值/涂抹样品前测试值,记为皮肤相对含水量,相对含水量对时间作图,得图1。可以看出,类菌孢素-甘氨酸的加入有助于提高精华液的保湿性能,而且随着加入百分比的增加,保湿性越强。本发明未添加传统防腐剂,乳酸杆菌发酵产物、葡萄柚籽提取物和艾叶提取物的组合能起抑菌作用,微生物挑战性实验表明实施例对金黄色葡萄球菌、铜绿假单胞菌、粪大肠菌群、霉菌和酵母菌等具有抑制效果(见下表),符合《化妆品安全技术规范2015版》标准。

Claims (2)

1.一种自防腐保湿精华液,除含有精华液可接受的一般成份外,还含有:
占精华液重量3.3%-19.3%的保湿成份,该保湿成份为占精华液重量1.0%-3.0%的甜菜碱、占精华液重量0.5%-1.0%的吡咯烷酮羧酸钠、占精华液重量1.0%-10%的库拉索芦荟叶水、占精华液重量0.5%-5.0%的仙人掌提取物以及0.3%透明质酸钠的组合;
占精华液重量0.01%-0.1%的谷胱甘肽;
占精华液重量0.1%的尿囊素;
占精华液重量0.4%-0.7%的增稠剂汉生胶;
占精华液重量1.4%-3.0%的具有自防腐作用的成份,该自防腐成份为0.1%-0.5%的葡萄柚籽提取物、0.8%-1.5%的乳酸杆菌发酵产物以及0.5%-1.0%的艾叶提取物的组合;
占精华液重量0.01%-2.0%的类菌孢素-甘氨酸,分子结构如下:
2.一种自防腐保湿精华液精华液,其特征在于其组份及其含量重量百分比分别为:
CN201811207261.5A 2018-10-17 2018-10-17 一种含类菌孢素-甘氨酸的自防腐保湿精华液 Withdrawn CN109260045A (zh)

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ES2301294A1 (es) * 2005-08-31 2008-06-16 Universidad De Malaga Uso de aminoacido tipo micosporina(m-gly) en productos para prevenciony tratamiento de eritema actinico fotocarcinogenesis y fotoenvejecimiento.
FR2986155B1 (fr) * 2012-01-31 2014-08-08 Blc Thalgo Cosmetic Lab Composition cosmetique photoprotectrice comprenant deux extraits algaux, utilisation d'extraits algaux pour la fabrication d'une telle composition
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CN106420843A (zh) * 2016-09-30 2017-02-22 中国海洋大学 一种紫菜类菌孢素氨基酸及其制备方法和应用
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