CN109259232A - 一种预防脑功能退化改善记忆的保健养生食品及其制备方法 - Google Patents
一种预防脑功能退化改善记忆的保健养生食品及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种预防脑功能退化改善记忆的保健养生食品及其制备方法，属于保健养生食品技术领域，改善记忆的保健养生食品包括以下重量份的原料：人参2‑10份、肉苁蓉2‑20份、天麻2‑20份、酸枣仁2‑30份和地龙蛋白肽2‑20份。本发明是充分发挥中医特色的疾病预防理论：“治未病”，“未病先防”、“既病防变”、“瘥后防复”，对于预防脑功能退化改善记忆具有重要意义。根据中医药的作用机理创新性将“药食同源”“新食品原料”科学组合，制成具有预防脑功能退化，安神、改善记忆、预防老年性痴呆的保健养生食品，用于防治中老年人群脑功能衰老退化所致记忆力减退，调理脑力工作者用脑过度所致的失眠、健忘、记忆减退等症状。
Description
技术领域
本发明涉及保健养生食品的技术领域，尤其涉及一种预防脑功能退化改善记忆的保健养生食品及其制备方法。
背景技术
老年性痴呆属于中医“痴呆、健忘”等范畴。中医认为，脑为元神之府，髓之海，神灵记性皆赖于脑。痴呆虽病位在脑，但与心、肝、肾等脏器功能有关，尤与肾的关系最为密切。肾为先天之本，主骨生髓，肾精充足，则髓海得以充养，神机自如，若先天禀赋不足或年老体虚，脏腑功能衰退，肾精不足，则髓海空虚，神机失用而成痴呆；或年老气血运行迟缓，气机不畅，久病人络，血脉凝滞，瘀阻脑络，清窍失灵，发为痴呆。故治疗应以补肾填精、逐瘀醒脑为原则。
发明内容
本发明是充分发挥中医药治未病的优势，以预防为主，治疗为辅。根据中医药的作用机理创新性将“药食同源”、“新食品原料”科学组合，制成具有预防脑功能退化，安神、改善记忆、预防老年性痴呆的保健养生食品，用于防治中老年人群脑功能衰老退化所致记忆力减退，调理脑力工作者用脑过度所致的失眠、健忘、记忆减退等症状。
为了实现上述目的，本发明提供如下技术方案：
一种预防脑功能退化改善记忆的保健养生食品，包括以下重量份的原料：人参2-10份、肉苁蓉2-20份、天麻2-20份、酸枣仁2-30份和地龙蛋白肽2-20份。
优选地，上述的预防脑功能退化改善记忆的保健养生食品，包括以下重量份的原料：人参3份、肉苁蓉10份、天麻10份、酸枣仁20份和地龙蛋白肽10份。
优选地，上述的预防脑功能退化改善记忆的保健养生食品，通过常规技术手段将其制备成膏剂、胶囊剂、片剂、颗粒剂、口服液或粉剂。
本发明还提供了上述的预防脑功能退化改善记忆的保健养生食品的制备方法，包括以下步骤：
(1)预处理
将人参、肉苁蓉、天麻、酸枣仁，筛选、清洗，切片，按所述重量份一起放入煎煮罐中，加入7-9倍量水浸泡3-5小时；
(2)煎煮
第一次煎煮：将步骤(1)浸泡后的药材煮沸1～3h，分离煎出液；
第二次煎煮：将第一次蒸煮所得药渣加5-7倍水，煮沸1～3h分离煎出液；
第三次煎煮：将第二次煎煮所得药渣加3-5倍水，煮沸0.5～1.5h分离煎出液；
(3)低温沉降
将步骤(2)三次煎出液合并，滤过，放入储液罐，8～10℃条件下静置34～36h，然后虹吸上清液；
(4)浓缩
将步骤(3)所得上清液进行真空浓缩处理，所得浓缩膏在70-90℃下0.05-0.1MPa真空干燥，粉碎80目，得中药提取物细粉；
(5)混合
将步骤(4)中药提取物细粉与所述重量份的地龙蛋白肽和维生素E一起混均、分装，6～10g/袋，即得预防脑功能退化改善记忆的保健养生食品。
优选地，上述的预防脑功能退化改善记忆的保健养生食品的制备方法，包括以下步骤：
(1)预处理
将人参、肉苁蓉、天麻、酸枣仁，筛选、清洗，切片，按所述重量份一起放入煎煮罐中，加入8倍量水浸泡4小时；
(2)煎煮
第一次煎煮：将步骤(1)浸泡后的药材煮沸2h，分离煎出液；
第二次煎煮：将第一次蒸煮所得药渣加6倍水，煮沸2h分离煎出液；
第三次煎煮：将第二次煎煮所得药渣加4倍水，煮沸1h分离煎出液；
(3)低温沉降
将步骤(2)三次煎出液合并，滤过，放入储液罐，8℃条件下静置36h，然后虹吸上清液；
(4)浓缩
将步骤(3)所得上清液进行真空浓缩处理，所得浓缩膏在80℃下0.08MPa真空干燥，粉碎80目，得中药提取物细粉；
(5)混合
将步骤(4)中药提取物细粉与所述重量份的地龙蛋白肽一起混均、分装，8g/袋，即得预防脑功能退化改善记忆的保健养生食品。
本发明方法制备的预防脑功能退化改善记忆的保健养生食品，其服用方法为：每次1袋，每日2次，温开水送服。
本发明中采用人参，其味甘、微苦，性微温，归脾、肺、心、肾经，具有大补元气，复脉固脱，补脾益肺，生津养血，安神益智之功效，可增加脑葡萄糖的摄取，同时减少乳酸、丙酮酸和乳酸/丙酮酸的比值，并可使葡萄糖的利用从无氧代谢途径转变为有氧代谢。人参亦可使大脑皮层中自由的无机磷增加。人参果皂甙能提高脑摄氧能力，人参总皂甙、人参根总皂甙对脑缺血/再灌注损伤均有保护作用。总之，人参能使动物大脑更合理地利用能量物质葡萄糖，氧化产能，合成更多的ATP供学习记忆等活动之用。
肉苁蓉，素有“沙漠人参”之美誉，其味甘、咸，性温，归肾、大肠经，具有补肾阳，益精血，润肠通便至功效。可激活肾上腺、释放皮质激素。补肾的主要意义在于改善机体内的调节机制，通过机体本身内在功能恢复而起积极的治疗作用，提高DNA合成率降低，促进RNA的合成，提高蛋白的核酸代谢，改善蛋白质、能量代谢紊乱造成的阳虚。
天麻，味甘，性平，归肝经，具有息风止痉，平抑肝阳，祛风通络，明目增智之功效，对人的大脑神经系统具有明显的保护和调节作用，能增强视神经的分辨能力，可改善肾虚引起的头痛头晕同时伴有记忆力减退的症状。
酸枣仁，味甘、酸，性平，归肝、胆、心经，具有养心补肝，宁心安神，敛汗，生津之功效。用于虚烦不眠，惊悸多梦，体虚多汗，津伤口渴，失眠健忘。
地龙味咸，性寒，归肝、脾、膀胱经。具有清热定惊，通络，平喘，利尿之功效。用于高热神昏，惊痫抽搐，关节痹痛，肢体麻木，半身不遂，肺热喘咳，水肿尿少。地龙蛋白肽，为地龙的提取物，活性高，分子链小，能疏通全身的血管网络，保证身体各个细胞、组织、器官获得充足的营养供应，可用于帕金森、脑萎缩、老年痴呆、脑瘫等疾病的治疗。
与现有技术相比，本发明的有益效果为：
中医在防治中老年人群脑功能衰老退化所致记忆力减退等症状具有独到的理论和丰富的治疗方法，在临床治疗和康复过程中已经收到满意的疗效，显示出无可比拟的优势。本发明是充分发扬祖国医学“治未病”的理念以预防为主，治疗为辅，采用人参、肉苁蓉、天麻、酸枣仁、地龙蛋白肽，通过优化成分组合及用量，创新性将“药食同源”、“新食品原料”科学组合，制成有一种预防脑功能退化，安神、改善记忆、预防老年性痴呆的保健养生食品，能够调整神经，镇静安神，增强记忆，抗疲劳，提高机体免疫力，用于防治中老年人群脑功能衰老退化所致记忆力减退，调理脑力工作者用脑过度所致的失眠、健忘、记忆力减退等症状。
具体实施方式
为了使本领域的技术人员更好地理解本发明的技术方案，下面将结合实施例对本发明作进一步的详细介绍。实施例中所采用的原材料、设备等除特殊限定外均可以通过购买方式获得。
实施例1预防脑功能退化改善记忆的保健养生食品的颗粒剂制备
(1)预处理
取人参、肉苁蓉、天麻、酸枣仁，筛选、清洗，切片，将人参2g、肉苁蓉2g、天麻2g、酸枣仁2g一起放入煎煮罐中，加入7倍量水浸泡3小时；
(2)煎煮
第一次煎煮：将步骤(1)浸泡后的药材煮沸1h，分离煎出液；
第二次煎煮：将第一次蒸煮所得药渣加5倍水，煮沸1h分离煎出液；
第三次煎煮：将第二次煎煮所得药渣加3倍水，煮沸0.5h分离煎出液；
(3)低温沉降
将步骤(2)三次煎出液合并，滤过，放入储液罐，8℃条件下静置34h，然后虹吸上清液；
(4)浓缩
将步骤(3)所得上清液进行真空浓缩处理，所得浓缩膏在70℃下0.1MPa真空干燥，粉碎80目，得中药提取物细粉；
(5)混合
将步骤(4)中药提取物细粉与地龙蛋白肽2g一起混均、分装，6g/袋，即得预防脑功能退化改善记忆的保健养生食品。
实施例2预防脑功能退化改善记忆的保健养生食品的颗粒剂制备
(1)预处理
取人参、肉苁蓉、天麻、酸枣仁，筛选、清洗，切片，将人参3g、肉苁蓉10g、天麻10g、酸枣仁20g一起放入煎煮罐中，加入8倍量水浸泡4小时；
(2)煎煮
第一次煎煮：将步骤(1)浸泡后的药材煮沸2h，分离煎出液；
第二次煎煮：将第一次蒸煮所得药渣加6倍水，煮沸2h分离煎出液；
第三次煎煮：将第二次煎煮所得药渣加4倍水，煮沸1h分离煎出液；
(3)低温沉降
将步骤(2)三次煎出液合并，滤过，放入储液罐，10℃条件下静置35h，然后虹吸上清液；
(4)浓缩
将步骤(3)所得上清液进行真空浓缩处理，所得浓缩膏在80℃下0.08MPa真空干燥，粉碎80目，得中药提取物细粉；
(5)混合
将步骤(4)中药提取物细粉与地龙蛋白肽10g一起混均、分装，8g/袋，即得预防脑功能退化改善记忆的保健养生食品。
实施例3预防脑功能退化改善记忆的保健养生食品的颗粒剂制备
(1)预处理
取人参、肉苁蓉、天麻、酸枣仁，筛选、清洗，切片，将人参10g、肉苁蓉20g、天麻20g、酸枣仁30g一起放入煎煮罐中，加入9倍量水浸泡5小时；
(2)煎煮
第一次煎煮：将步骤(1)浸泡后的药材煮沸3h，分离煎出液；
第二次煎煮：将第一次蒸煮所得药渣加7倍水，煮沸3h分离煎出液；
第三次煎煮：将第二次煎煮所得药渣加5倍水，煮沸1.5h分离煎出液；
(3)低温沉降
将步骤(2)三次煎出液合并，滤过，放入储液罐，10℃条件下静置36h，然后虹吸上清液；
(4)浓缩
将步骤(3)所得上清液进行真空浓缩处理，所得浓缩膏在90℃下0.1MPa真空干燥，粉碎80目，得中药提取物细粉；
(5)混合
将步骤(4)中药提取物细粉与地龙蛋白肽20g一起混均、分装，10g/袋，即得预防脑功能退化改善记忆的保健养生食品。
此外，还可以通过常规技术手段将上述实施例步骤5的预防脑功能退化改善记忆的保健养生食品进一步制备成胶囊剂、片剂、粉剂等剂型。
试验例1
(1)方法与资料
32例确诊为老年痴呆患者，年龄65岁以上，男患者21例，女患者11例，均为轻度痴呆期。表现为记忆减退，对近事遗忘突出；判断能力下降，病人不能对事件进行分析、思考、判断，难以处理复杂的问题。将32例患者随机分为4个组，实验组1～3和空白对照组，每组各8例。实验组1～3分别采用本发明的实施例1～3制备的预防脑功能退化改善记忆的保健养生食品，每日1袋，每日两次，早晚各一次，温水服用；空白对照组不服用。2个月为1个疗程，实验组1～3均服用3个疗程，6个月后观察患者状态。
(2)实验结果
实验组1～3的患者服用本发明提供的预防脑功能退化改善记忆的保健养生食品，记忆力明显增强，判断能力有所提升，生活的能力与正常人基本相同，空白对照组患者症状无任何改善，甚至病情加重，进展到中度痴呆期，综上，本发明的保健养生食品，长期使用安全、无毒副作用，具有显著的效果。
以上实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述各实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换，但这些修改或者替换，并不使相应技术方案的本质脱离本发明各实施例技术方案的精神和范围。
Claims (5)
1.一种预防脑功能退化改善记忆的保健养生食品，其特征在于，包括以下重量份的原料：人参2-10份、肉苁蓉2-20份、天麻2-20份、酸枣仁2-30份和地龙蛋白肽2-20份。
2.根据权利要求1所述的预防脑功能退化改善记忆的保健养生食品，其特征在于，包括以下重量份的原料：人参3份、肉苁蓉10份、天麻10份、酸枣仁20份和地龙蛋白肽10份。
3.根据权利要求1或2所述的预防脑功能退化改善记忆的保健养生食品，其特征在于，通过常规技术手段将其制备成膏剂、胶囊剂、片剂、颗粒剂、口服液或粉剂。
4.根据权利要求1或2所述的预防脑功能退化改善记忆的保健养生食品的制备方法，其特征在于，包括以下步骤：
(1)预处理
将人参、肉苁蓉、天麻、酸枣仁，筛选、清洗，切片，按所述重量份一起放入煎煮罐中，加入7-9倍量水浸泡3-5小时；
(2)煎煮
第一次煎煮：将步骤(1)浸泡后的药材煮沸1～3h，分离煎出液；
第二次煎煮：将第一次蒸煮所得药渣加5-7倍水，煮沸1～3h分离煎出液；
第三次煎煮：将第二次煎煮所得药渣加3-5倍水，煮沸0.5～1.5h分离煎出液；
(3)低温沉降
将步骤(2)三次煎出液合并，滤过，放入储液罐，8～10℃条件下静置34～36h，然后虹吸上清液；
(4)浓缩
将步骤(3)所得上清液进行真空浓缩处理，所得浓缩膏在70-90℃下0.05-0.1MPa真空干燥，粉碎80目，得中药提取物细粉；
(5)混合
将步骤(4)中药提取物细粉与所述重量份的地龙蛋白肽一起混均、分装，6～10g/袋，即得预防脑功能退化改善记忆的保健养生食品。
5.根据权利要求4所述的预防脑功能退化改善记忆的保健养生食品的制备方法，其特征在于，包括以下步骤：
(1)预处理
将人参、肉苁蓉、天麻、酸枣仁，筛选、清洗，切片，按所述重量份一起放入煎煮罐中，加入8倍量水浸泡4小时；
(2)煎煮
第一次煎煮：将步骤(1)浸泡后的药材煮沸2h，分离煎出液；
第二次煎煮：将第一次蒸煮所得药渣加6倍水，煮沸2h分离煎出液；
第三次煎煮：将第二次煎煮所得药渣加4倍水，煮沸1h分离煎出液；
(3)低温沉降
将步骤(2)三次煎出液合并，滤过，放入储液罐，8℃条件下静置36h，然后虹吸上清液；
(4)浓缩
将步骤(3)所得上清液进行真空浓缩处理，所得浓缩膏在80℃下0.08MPa真空干燥，粉碎80目，得中药提取物细粉；
(5)混合
将步骤(4)中药提取物细粉与所述重量份的地龙蛋白肽一起混均、分装，8g/袋，即得预防脑功能退化改善记忆的保健养生食品。
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