CN109224118A - A kind of medical operation suture thread - Google Patents
A kind of medical operation suture thread Download PDFInfo
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- CN109224118A CN109224118A CN201811111447.0A CN201811111447A CN109224118A CN 109224118 A CN109224118 A CN 109224118A CN 201811111447 A CN201811111447 A CN 201811111447A CN 109224118 A CN109224118 A CN 109224118A
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- acid
- medical operation
- operation suture
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- suture thread
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/005—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/105—Polyesters not covered by A61L17/12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/06—At least partially resorbable materials
- A61L17/10—At least partially resorbable materials containing macromolecular materials
- A61L17/12—Homopolymers or copolymers of glycolic acid or lactic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
- A61L17/14—Post-treatment to improve physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The invention discloses a kind of medical operation suture threads, are grouped as by each group of following mass parts: 5- hydantoin acetic acid is poly-D-lysine 20-30 parts modified, 10-20 parts of polyethylene glycol carboxylic acid polydactyl acid, is based on 45-55 parts of sodium alginate polycaprolactone analog copolymer, 10-20 parts of gamma-cyclodextrin, 5-10 parts of hydroxy butyl methyl cellulose.Medical operation suture thread disclosed by the invention has the advantages of the effect of absorption is complete, tensile strength height, good biocompatibility, cell can be promoted to grow, and is provided simultaneously with bactericidal antiphlogistic, hemostasis.
Description
Technical field
The present invention relates to field of medical article technology more particularly to a kind of medical operation suture thread and preparation method thereof.
Background technique
Medical operation suture thread refer in surgical operation or wound disposition in, for hemostasis by ligation, suture stop
Blood and the distinct line of tissue suture, it plays a very important role to the initial stage healing of wound.Generally can be divided into absorbable thread and
Two class of nonabsorable line, nonabsorable suture is non-degradable in vivo, if do not taken out, as body foreign matter stay in the tissue, compared with
Easily cause tissue infection；Absorbable thread suture is depended in bodily tissue by acid, alkali or enzyme effect degradation, degradation speed
Liquid environment around the temperature, pH value and suture of tissue, product is converted into metabolite and the excretion of human body after degradation
Object, it is nontoxic.Therefore, medical absorbable suture is the development trend of medical operation suture thread, before important application
Scape.
Absorbable suture common in the art can be divided into according to material and degree of absorption difference: catgut, chemistry
Synthetic thread, pure-natural collagen suture.These absorbable sutures come with some shortcomings, and catgut easily causes calculus,
And absorbability is bad；Chemical synthesis line absorption is slow, is unfavorable for accelerating wound resume speed；Pure-natural collagen suture materials
Difficulty, it is at high cost, be not suitable for a wide range of use.
Chinese invention patent publication number CN1051510A proposes a kind of collagen-polyvinyl medical absorbable suture
Preparation method, but since the degradation of this collagen line in vivo is that dissolution, swelling first occurs, it then degrades, is easy suture
Generation largely expands, and causes ligation loosely.A kind of chitosan of the patent report of Publication No. CN102573935A can
The preparation method of absorbable suture line is generally used for the necessary viscosity with higher of chitosan of spinning manufacture suture, therefore right
In the more demanding of raw material；In addition, chitosan derive from animal body, influenced by raw material, product properties stability compared with
Difference.
Therefore, develop it is a kind of prepare simple, good biocompatibility, absorb sufficiently, mechanical performance it is excellent, and there is sterilization to disappear
The medical operation suture thread of inflammation effect accords with the demands of the market, and has extensive market value and application prospect.
Summary of the invention
In order to overcome the defects of the prior art, the present invention provides a kind of medical operation suture thread and preparation method thereof, should
Preparation method is simple, and raw material is easy to get, cheap, is suitble to large-scale production.The medical operation suture thread gram being prepared
Having taken traditional operation suture in the prior art, more or less existing tensile strength and elongation are low, sewing effect is poor, raw
Object compatibility is bad, absorbs defect that is incomplete, be easy to causeing calculus, and with absorbing, complete, tensile strength is high, biocompatibility
Well, the advantages of the effect of cell capable of being promoted to grow, being provided simultaneously with bactericidal antiphlogistic, hemostasis.
To achieve the above object of the invention, the technical solution adopted by the present invention is that, a kind of medical operation suture thread, by following matter
The each group of amount part is grouped as: 5- hydantoin acetic acid modified poly-D-lysine 20-30 parts, polyethylene glycol carboxylic acid polydactyl acid 10-
20 parts, be based on 45-55 parts of sodium alginate polycaprolactone analog copolymer, 10-20 parts of gamma-cyclodextrin, hydroxy butyl methyl cellulose 5-
10 parts.
Preferably, the preparation method of the modified poly-D-lysine of the 5- hydantoin acetic acid, includes the following steps: 5- glycolylurea second
Acid, which is dissolved in organic solvent, forms solution, then poly-D-lysine, 1- (3- dimethylamino-propyl) -3- ethyl carbon are added into solution
Diimmonium salt hydrochlorate, I-hydroxybenzotriazole are stirred to react 6-8 hours at 60-80 DEG C, and solvent is evaporated off in back spin, and successively
It is washed 3-5 times respectively with ethyl alcohol, water, then is placed in a vacuum drying oven baking 15-20 hours, obtained the modified poly of 5- hydantoin acetic acid and rely
Propylhomoserin.
Preferably, the 5- hydantoin acetic acid, organic solvent, poly-D-lysine, 1- (3- dimethylamino-propyl) -3- ethyl carbon
Diimmonium salt hydrochlorate, I-hydroxybenzotriazole mass ratio be 1:(10-15): (3-5): 0.5:0.3.
Preferably, the organic solvent is selected from one of methylene chloride, ethyl acetate, dimethyl sulfoxide.
Preferably, the preparation method of the polyethylene glycol carboxylic acid polydactyl acid, includes the following steps: polyethylene glycol
Carboxylic acid, polylactic acid are added in dioxane, then the concentrated sulfuric acid is added thereto, and back flow reaction 8-10 is small at 170-180 DEG C
When, dioxane is evaporated off in back spin, washing is added thereto, until eluate obtains polyethylene glycol carboxylic acid and change close to neutrality
Property polylactic acid.
Preferably, the polyethylene glycol carboxylic acid, polylactic acid, dioxane, the concentrated sulfuric acid mass ratio be 1:2:(10-
15):0.3。
Preferably, the preparation method based on sodium alginate polycaprolactone analog copolymer, includes the following steps: Malaysia
Acid imide end group polycaprolactone, allyl glycolylurea, food-grade sodium alginate, silver-colored methacrylate, 5- vinyl -2- thiazole
Amine, initiator, emulsifier are added in the mixed solvent, and it is small to be stirred to react 4-6 at nitrogen or 80-90 DEG C of atmosphere of inert gases
When, solvent is evaporated off in back spin, obtains based on sodium alginate polycaprolactone analog copolymer.
Preferably, the terminal maleimide group polycaprolactone is previously prepared, preparation method reference: Zhang, M.J.；
Liu,H.H.；Shao,W.；Miao,K.；Zhao,Y.L.Synthesis and properties of multicleavable
amphiphilic dendritic comblike and toothbrushlike copolymers comprising
alternating PEG and PCL grafts.Macromolecules,2013,46,1325-1336。
Preferably, the terminal maleimide group polycaprolactone, allyl glycolylurea, food-grade sodium alginate, silver-colored methyl-prop
Olefin(e) acid salt, 5- vinyl-abadol, initiator, emulsifier, mixed solvent mass ratio be 2:1:1:0.5:0.2:(0.03-
0.05):0.04:(20-25)。
Preferably, the initiator is selected from one or more of potassium peroxydisulfate, sodium peroxydisulfate, ammonium persulfate.
Preferably, the emulsifier is selected from lauryl sodium sulfate salt, dodecyl sodium sulfate salt, aliphatic alcohol polyethenoxy
One or more of ether, sorbitan fatty acid ester polyoxyethylene ether, sorbitan fatty acid ester.
Preferably, the mixed solvent is n,N-Dimethylformamide and the mixture that water 1:1 in mass ratio is mixed.
Preferably, the inert gas is selected from one of helium, neon, argon gas.
Preferably, a kind of preparation method of medical operation suture thread includes the following steps: to add raw material according to quality proportioning
Enter into high-speed mixer, is mixed 20-30 minutes in the case where revolving speed is 70-90r/min, obtain mixture；Then mixture is sent
Enter in double screw extruder to be granulated, is cooling, is dry, obtaining master batch after cutting；Master batch melting is carried out afterwards to reel off raw silk from cocoons into diameter and be
The silk thread of 0.02-0.05mm；Silk thread is put into medicinal alcohol again and sterilizes 2-3h, is finally dried in vacuo up to medical operation suture
Line.
Preferably, the double screw extruder temperature is 220-250 DEG C, screw speed 1100-1300r/min.
The beneficial effects of adopting the technical scheme are that
1) medical operation suture thread provided by the invention, preparation method is simple, and raw material is easy to get, cheap, is suitble to
Large-scale production.
2) it is more or less to overcome traditional operation suture in the prior art for medical operation suture thread provided by the invention
Existing tensile strength and elongation are low, sewing effect is poor, biocompatibility is bad, absorption is incomplete, be easy to cause calculus
Defect, have absorb completely, tensile strength height, good biocompatibility, cell can be promoted to grow, be provided simultaneously with bactericidal antiphlogistic, stop
The advantages of the effect of blood.
3) medical operation suture thread provided by the invention improves its parent using polyethylene glycol carboxylic acid polydactyl acid
Aqueous and moistened surface degree, to be conducive to the healing of wound, mitigates so that it has moisture-absorbing moisture-keeping effect of preferably sucking blood
Patient suffering reduces inflammation probability, improves success rate of operation；Main chain passes through terminal maleimide group polycaprolactone, allyl sea
Cause, food-grade sodium alginate, silver-colored methacrylate, 5- vinyl-abadol copolymerization, synergistic effect improve suture
Biocompatibility and antibiotic property, and there is universal；By copolymerization, be conducive to adjust each section specific gravity, to set as needed
Count more reasonable structure；Food-grade sodium alginate be introduced into the form of comonomer in strand than be directly added into or by from
Sub-key introducing is more stable, and dispersion more evenly, is conducive to the stability for improving suture；Thiazolyl, silver ion, glycolylurea and more
Polylysine structure synergistic effect, can improve the anti-microbial property of material；Cyclodextrin is added, distinctive structure is conducive to mention
High suture comprehensive performance；The addition of polylactic acid, polycaprolactone structure is conducive to its biodegrade, and use is safe and harmless, health
Environmental protection；Each raw material synergistic effect, so that suture excellent combination property.
Specific embodiment
In order to make those skilled in the art more fully understand technical solution of the present invention, and make features described above of the invention,
Purpose and advantage are more clear understandable, and the present invention will be further explained with reference to the examples below.Embodiment is only used for
It is bright the present invention rather than limit the scope of the invention.
Present invention terminal maleimide group polycaprolactone as used in the following examples is previously prepared, preparation method ginseng
It examines: Zhang, M.J.；Liu,H.H.；Shao,W.；Miao,K.；Zhao,Y.L.Synthesis and properties of
multicleavable amphiphilic dendritic comblike and toothbrushlike copolymers
comprising alternating PEG and PCL grafts.Macromolecules,2013,46,1325-1336；Its
He is purchased from Sinopharm Chemical Reagent Co., Ltd. by raw material.
Embodiment 1
A kind of medical operation suture thread is grouped as by each group of following mass parts: the modified poly-D-lysine of 5- hydantoin acetic acid
20 parts, 10 parts of polyethylene glycol carboxylic acid polydactyl acid, be based on 45 parts of sodium alginate polycaprolactone analog copolymer, gamma-cyclodextrin
10 parts, 5 parts of hydroxy butyl methyl cellulose.
The preparation method of the modified poly-D-lysine of the 5- hydantoin acetic acid, includes the following steps: 5- hydantoin acetic acid 10g is molten
Solution is formed in methylene chloride 100g, then poly-D-lysine 30g, 1- (3- dimethylamino-propyl) -3- second is added into solution
Base carbodiimide hydrochloride 5g, I-hydroxybenzotriazole 3g are stirred to react 6 hours at 60 DEG C, and back spin is evaporated off solvent, and according to
It is secondary to be washed respectively 3 times with ethyl alcohol, water, then it is placed in a vacuum drying oven baking 15 hours, it obtains the modified poly of 5- hydantoin acetic acid and relies ammonia
Acid.
The preparation method of the polyethylene glycol carboxylic acid polydactyl acid includes the following steps: polyethylene glycol carboxylic acid
10g, polylactic acid 20g are added in dioxane 100g, then concentrated sulfuric acid 3g is added thereto, and back flow reaction 8 is small at 170 DEG C
When, dioxane is evaporated off in back spin, washing is added thereto, until eluate obtains polyethylene glycol carboxylic acid and change close to neutrality
Property polylactic acid.
The preparation method based on sodium alginate polycaprolactone analog copolymer, includes the following steps: maleimide
End group polycaprolactone 20g, allyl glycolylurea 10g, food-grade sodium alginate 10g, silver-colored methacrylate 5g, 5- vinyl -2-
Thiazole amine 2g, potassium peroxydisulfate 0.3g, lauryl sodium sulfate salt 0.4g are added in mixed solvent 200g, at 80 DEG C of nitrogen atmosphere
Under be stirred to react 4 hours, solvent is evaporated off in back spin, obtains based on sodium alginate polycaprolactone analog copolymer.
The mixed solvent is the mixture that N,N-dimethylformamide and water 1:1 in mass ratio are mixed.
A kind of preparation method of medical operation suture thread, includes the following steps: to add the raw material into height according to quality proportioning
In fast mixing machine, is mixed 20 minutes in the case where revolving speed is 70r/min, obtain mixture；Then twin-screw extrusion is fed the mixture into
It is granulated in machine, is cooling, is dry, obtaining master batch after cutting；Master batch is subjected to melting afterwards and reels off raw silk from cocoons into the silk thread that diameter is 0.02mm；Again
Silk thread is put into medicinal alcohol and sterilizes 2h, is finally dried in vacuo up to medical operation suture thread.
The double screw extruder temperature is 220 DEG C, screw speed 1100r/min.
Embodiment 2
A kind of medical operation suture thread is grouped as by each group of following mass parts: the modified poly-D-lysine of 5- hydantoin acetic acid
23 parts, 13 parts of polyethylene glycol carboxylic acid polydactyl acid, be based on 48 parts of sodium alginate polycaprolactone analog copolymer, gamma-cyclodextrin
13 parts, 6 parts of hydroxy butyl methyl cellulose.
The preparation method of the modified poly-D-lysine of the 5- hydantoin acetic acid, includes the following steps: 5- hydantoin acetic acid 10g is molten
Solution is formed in ethyl acetate 115g, then poly-D-lysine 35g, 1- (3- dimethylamino-propyl) -3- second is added into solution
Base carbodiimide hydrochloride 5g, I-hydroxybenzotriazole 3g are stirred to react 6.5 hours at 65 DEG C, and solvent is evaporated off in back spin, and
It is successively washed respectively 4 times with ethyl alcohol, water, then is placed in a vacuum drying oven baking 16 hours, obtained the modified poly of 5- hydantoin acetic acid and rely
Propylhomoserin.
The preparation method of the polyethylene glycol carboxylic acid polydactyl acid includes the following steps: polyethylene glycol carboxylic acid
10g, polylactic acid 20g are added in dioxane 115g, then concentrated sulfuric acid 3g is added thereto, and back flow reaction 8.5 is small at 173 DEG C
When, dioxane is evaporated off in back spin, washing is added thereto, until eluate obtains polyethylene glycol carboxylic acid and change close to neutrality
Property polylactic acid.
The preparation method based on sodium alginate polycaprolactone analog copolymer, includes the following steps: maleimide
End group polycaprolactone 20g, allyl glycolylurea 10g, food-grade sodium alginate 10g, silver-colored methacrylate 5g, 5- vinyl -2-
Thiazole amine 2g, sodium peroxydisulfate 0.35g, dodecyl sodium sulfate salt 0.4g are added in mixed solvent 215g, in helium atmosphere 83
It is stirred to react at DEG C 4.5 hours, solvent is evaporated off in back spin, obtains based on sodium alginate polycaprolactone analog copolymer.
The mixed solvent is the mixture that N,N-dimethylformamide and water 1:1 in mass ratio are mixed.
A kind of preparation method of medical operation suture thread, includes the following steps: to add the raw material into height according to quality proportioning
In fast mixing machine, is mixed 23 minutes in the case where revolving speed is 75r/min, obtain mixture；Then twin-screw extrusion is fed the mixture into
It is granulated in machine, is cooling, is dry, obtaining master batch after cutting；Master batch is subjected to melting afterwards and reels off raw silk from cocoons into the silk thread that diameter is 0.03mm；Again
Silk thread is put into medicinal alcohol and sterilizes 2.3h, is finally dried in vacuo up to medical operation suture thread.
The double screw extruder temperature is 230 DEG C, screw speed 1150r/min.
Embodiment 3
A kind of medical operation suture thread is grouped as by each group of following mass parts: the modified poly-D-lysine of 5- hydantoin acetic acid
25 parts, 15 parts of polyethylene glycol carboxylic acid polydactyl acid, be based on 50 parts of sodium alginate polycaprolactone analog copolymer, gamma-cyclodextrin
15 parts, 7 parts of hydroxy butyl methyl cellulose.
The preparation method of the modified poly-D-lysine of the 5- hydantoin acetic acid, includes the following steps: 5- hydantoin acetic acid 10g is molten
Solution is formed in dimethyl sulfoxide 130g, then poly-D-lysine 40g, 1- (3- dimethylamino-propyl) -3- second is added into solution
Base carbodiimide hydrochloride 5g, I-hydroxybenzotriazole 3g are stirred to react 7 hours at 70 DEG C, and back spin is evaporated off solvent, and according to
It is secondary to be washed respectively 4 times with ethyl alcohol, water, then it is placed in a vacuum drying oven baking 17 hours, it obtains the modified poly of 5- hydantoin acetic acid and relies ammonia
Acid.
The preparation method of the polyethylene glycol carboxylic acid polydactyl acid includes the following steps: polyethylene glycol carboxylic acid
10g, polylactic acid 20g are added in dioxane 135g, then concentrated sulfuric acid 3g is added thereto, and back flow reaction 9 is small at 175 DEG C
When, dioxane is evaporated off in back spin, washing is added thereto, until eluate obtains polyethylene glycol carboxylic acid and change close to neutrality
Property polylactic acid.
The preparation method based on sodium alginate polycaprolactone analog copolymer, includes the following steps: maleimide
End group polycaprolactone 20g, allyl glycolylurea 10g, food-grade sodium alginate 10g, silver-colored methacrylate 5g, 5- vinyl -2-
Thiazole amine 2g, ammonium persulfate 0.4g, fatty alcohol polyoxyethylene ether 0.4g are added in mixed solvent 230g, at 85 DEG C of neon atmosphere
Under be stirred to react 5 hours, solvent is evaporated off in back spin, obtains based on sodium alginate polycaprolactone analog copolymer.
The mixed solvent is the mixture that N,N-dimethylformamide and water 1:1 in mass ratio are mixed.
A kind of preparation method of medical operation suture thread, includes the following steps: to add the raw material into height according to quality proportioning
In fast mixing machine, is mixed 25 minutes in the case where revolving speed is 80r/min, obtain mixture；Then twin-screw extrusion is fed the mixture into
It is granulated in machine, is cooling, is dry, obtaining master batch after cutting；Master batch is subjected to melting afterwards and reels off raw silk from cocoons into the silk thread that diameter is 0.04mm；Again
Silk thread is put into medicinal alcohol and sterilizes 2.5h, is finally dried in vacuo up to medical operation suture thread.
The double screw extruder temperature is 240 DEG C, screw speed 1200r/min.
Embodiment 4
A kind of medical operation suture thread is grouped as by each group of following mass parts: the modified poly-D-lysine of 5- hydantoin acetic acid
28 parts, 18 parts of polyethylene glycol carboxylic acid polydactyl acid, be based on 53 parts of sodium alginate polycaprolactone analog copolymer, gamma-cyclodextrin
18 parts, 9 parts of hydroxy butyl methyl cellulose.
The preparation method of the modified poly-D-lysine of the 5- hydantoin acetic acid, includes the following steps: 5- hydantoin acetic acid 10g is molten
Solution is formed in methylene chloride 145g, then poly-D-lysine 45g, 1- (3- dimethylamino-propyl) -3- second is added into solution
Base carbodiimide hydrochloride 5g, I-hydroxybenzotriazole 3g are stirred to react 7.8 hours at 78 DEG C, and solvent is evaporated off in back spin, and
It is successively washed respectively 5 times with ethyl alcohol, water, then is placed in a vacuum drying oven baking 19 hours, obtained the modified poly of 5- hydantoin acetic acid and rely
Propylhomoserin.
The preparation method of the polyethylene glycol carboxylic acid polydactyl acid includes the following steps: polyethylene glycol carboxylic acid
10g, polylactic acid 20g are added in dioxane 145g, then concentrated sulfuric acid 3g is added thereto, and back flow reaction 9.5 is small at 177 DEG C
When, dioxane is evaporated off in back spin, washing is added thereto, until eluate obtains polyethylene glycol carboxylic acid and change close to neutrality
Property polylactic acid.
The preparation method based on sodium alginate polycaprolactone analog copolymer, includes the following steps: maleimide
End group polycaprolactone 20g, allyl glycolylurea 10g, food-grade sodium alginate 10g, silver-colored methacrylate 5g, 5- vinyl -2-
Thiazole amine 2g, initiator 0.45g, emulsifier 0.4g are added in mixed solvent 245g, are stirred to react at 88 DEG C of argon atmosphere
5.5 hours, solvent was evaporated off in back spin, obtained based on sodium alginate polycaprolactone analog copolymer.
The initiator is the mixture that potassium peroxydisulfate, sodium peroxydisulfate, ammonium persulfate 2:3:1 in mass ratio are mixed.
The emulsifier is lauryl sodium sulfate salt, dodecyl sodium sulfate salt, fatty alcohol polyoxyethylene ether, dehydration mountain
The mixture that pears polyol fatty acid ester APEO, sorbitan fatty acid ester 1:1:2:1:3 in mass ratio are mixed.
The mixed solvent is the mixture that N,N-dimethylformamide and water 1:1 in mass ratio are mixed.
A kind of preparation method of medical operation suture thread, includes the following steps: to add the raw material into height according to quality proportioning
In fast mixing machine, is mixed 28 minutes in the case where revolving speed is 88r/min, obtain mixture；Then twin-screw extrusion is fed the mixture into
It is granulated in machine, is cooling, is dry, obtaining master batch after cutting；Master batch is subjected to melting afterwards and reels off raw silk from cocoons into the silk thread that diameter is 0.045mm；
Silk thread is put into medicinal alcohol again and sterilizes 2.8h, is finally dried in vacuo up to medical operation suture thread.
The double screw extruder temperature is 245 DEG C, screw speed 1250r/min.
Embodiment 5
A kind of medical operation suture thread is grouped as by each group of following mass parts: the modified poly-D-lysine of 5- hydantoin acetic acid
30 parts, 20 parts of polyethylene glycol carboxylic acid polydactyl acid, be based on 55 parts of sodium alginate polycaprolactone analog copolymer, gamma-cyclodextrin
20 parts, 10 parts of hydroxy butyl methyl cellulose.
The preparation method of the modified poly-D-lysine of the 5- hydantoin acetic acid, includes the following steps: 5- hydantoin acetic acid 10g is molten
Solution is formed in dimethyl sulfoxide 150g, then poly-D-lysine 50g, 1- (3- dimethylamino-propyl) -3- second is added into solution
Base carbodiimide hydrochloride 5g, I-hydroxybenzotriazole 3g are stirred to react 8 hours at 80 DEG C, and back spin is evaporated off solvent, and according to
It is secondary to be washed respectively 5 times with ethyl alcohol, water, then it is placed in a vacuum drying oven baking 20 hours, it obtains the modified poly of 5- hydantoin acetic acid and relies ammonia
Acid.
The preparation method of the polyethylene glycol carboxylic acid polydactyl acid includes the following steps: polyethylene glycol carboxylic acid
10g, polylactic acid 20g are added in dioxane 150g, then concentrated sulfuric acid 3g is added thereto, and back flow reaction 10 is small at 180 DEG C
When, dioxane is evaporated off in back spin, washing is added thereto, until eluate obtains polyethylene glycol carboxylic acid and change close to neutrality
Property polylactic acid.
The preparation method based on sodium alginate polycaprolactone analog copolymer, includes the following steps: maleimide
End group polycaprolactone 20g, allyl glycolylurea 10g, food-grade sodium alginate 10g, silver-colored methacrylate 5g, 5- vinyl -2-
Thiazole amine 2g, sodium peroxydisulfate 0.5g, sorbitan fatty acid ester 0.4g are added in mixed solvent 250g, in nitrogen atmosphere 90
It is stirred to react at DEG C 6 hours, solvent is evaporated off in back spin, obtains based on sodium alginate polycaprolactone analog copolymer.
The mixed solvent is the mixture that N,N-dimethylformamide and water 1:1 in mass ratio are mixed.
A kind of preparation method of medical operation suture thread, includes the following steps: to add the raw material into height according to quality proportioning
In fast mixing machine, is mixed 30 minutes in the case where revolving speed is 90r/min, obtain mixture；Then twin-screw extrusion is fed the mixture into
It is granulated in machine, is cooling, is dry, obtaining master batch after cutting；Master batch is subjected to melting afterwards and reels off raw silk from cocoons into the silk thread that diameter is 0.05mm；Again
Silk thread is put into medicinal alcohol and sterilizes 3h, is finally dried in vacuo up to medical operation suture thread.
The double screw extruder temperature is 250 DEG C, screw speed 1300r/min.
Comparative example
A kind of medical absorbable suture, according to Chinese invention patent CN 105133088B embodiment one formula and its
Preparation method is prepared.
1-5 of the embodiment of the present invention medical operation suture thread being prepared and comparative example operation suture thread are subjected to performance survey
Examination, testing standard and the results are shown in Table 1.
Table 1
As can be seen from Table 1, the embodiment of the present invention prepares resulting medical operation suture thread with more excellent mechanics
Performance, biocompatibility, sterilization anti-microbial property, and can absorb functional.
The basic principles, main features and advantages of the present invention have been shown and described above.The technology of the industry
Personnel are it should be appreciated that the present invention is not limited to the above embodiments, and what is described in the above embodiment and the description is only the present invention
Principle, various changes and improvements may be made to the invention without departing from the spirit and scope of the present invention, these variation and
Improvement is both fallen in the range of claimed invention.The present invention claims protection scope by appended claims and its
Equivalent defines.
Claims (10)
1. a kind of medical operation suture thread, which is characterized in that its component includes: 5- hydantoin acetic acid modified poly-D-lysine, poly- second
Glycol hydroxyl acid polydactyl acid is based on sodium alginate polycaprolactone analog copolymer, gamma-cyclodextrin, hydroxy butyl methyl cellulose.
2. medical operation suture thread according to claim 1, which is characterized in that the mass fraction of each component is as follows: the sea 5-
Gather oneself because of poly-D-lysine 20-30 parts of acetic acid modification, 10-20 parts of polyethylene glycol carboxylic acid polydactyl acid, based on sodium alginate
45-55 parts of lactone analog copolymer, 10-20 parts of gamma-cyclodextrin, 5-10 parts of hydroxy butyl methyl cellulose.
3. medical operation suture thread according to claim 1, which is characterized in that the modified poly of the 5- hydantoin acetic acid relies ammonia
The preparation method of acid, includes the following steps: for 5- hydantoin acetic acid to be dissolved in organic solvent and forms solution, then is added into solution more
Polylysine, 1- (3- dimethylamino-propyl) -3- ethyl-carbodiimide hydrochloride, I-hydroxybenzotriazole, are stirred at 60-80 DEG C
Reaction 6-8 hours is mixed, solvent is evaporated off in back spin, and is successively washed 3-5 times respectively with ethyl alcohol, water, then be placed in a vacuum drying oven
It dries 15-20 hours, obtains the modified poly-D-lysine of 5- hydantoin acetic acid.
4. medical operation suture thread according to claim 3, which is characterized in that the organic solvent be selected from methylene chloride,
One of ethyl acetate, dimethyl sulfoxide.
5. medical operation suture thread according to claim 1, which is characterized in that the modified poly- cream of the polyethylene glycol carboxylic acid
The preparation method of acid, includes the following steps: for polyethylene glycol carboxylic acid, polylactic acid to be added in dioxane, then adds thereto
Entering the concentrated sulfuric acid, back flow reaction 8-10 hours at 170-180 DEG C, dioxane is evaporated off in back spin, washing is added thereto, until
Eluate obtains polyethylene glycol carboxylic acid polydactyl acid close to neutrality.
6. medical operation suture thread according to claim 1, which is characterized in that described to be based on sodium alginate poly caprolactone
The preparation method of copolymer includes the following steps: terminal maleimide group polycaprolactone, allyl glycolylurea, food-grade seaweed
Sour sodium, silver-colored methacrylate, 5- vinyl-abadol, initiator, emulsifier are added in the mixed solvent, in nitrogen or
It is stirred to react at 80-90 DEG C of atmosphere of inert gases 4-6 hours, solvent is evaporated off in back spin, obtains based on sodium alginate polycaprolactone
Analog copolymer.
7. medical operation suture thread according to claim 6, which is characterized in that the initiator is selected from potassium peroxydisulfate, mistake
One or more of sodium sulphate, ammonium persulfate.
8. medical operation suture thread according to claim 6, which is characterized in that the emulsifier is selected from dodecyl sulphate
Sodium salt, dodecyl sodium sulfate salt, fatty alcohol polyoxyethylene ether, sorbitan fatty acid ester polyoxyethylene ether, Sorbitan
One or more of alcohol fatty acid ester.
9. medical operation suture thread according to claim 6, which is characterized in that the mixed solvent is N, N- dimethyl methyl
The mixture that amide and water 1:1 in mass ratio are mixed.
10. -9 described in any item medical operation suture threads according to claim 1, which is characterized in that the medical operation suture
The preparation method of line includes the following steps: to add the raw material into high-speed mixer according to quality proportioning, is 70- in revolving speed
It is mixed 20-30 minutes under 90r/min, obtains mixture；Then it feeds the mixture into double screw extruder and is granulated, is cooling, dry
Master batch is obtained after dry, cutting；Master batch is subjected to melting afterwards and reels off raw silk from cocoons into the silk thread that diameter is 0.02-0.05mm；Silk thread is put into again
2-3h is sterilized in medicinal alcohol, is finally dried in vacuo up to medical operation suture thread.
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011306603.6A CN112480420A (en) | 2018-09-23 | 2018-09-23 | Polyethylene glycol hydroxy acid modified polylactic acid beneficial to wound healing and application thereof |
| CN202011306632.2A CN112336911A (en) | 2018-09-23 | 2018-09-23 | Preparation method of medical surgical suture |
| CN201811111447.0A CN109224118B (en) | 2018-09-23 | 2018-09-23 | Medical operation suture line |
| CN202011311148.9A CN112430292A (en) | 2018-09-23 | 2018-09-23 | Antibacterial and degradable sodium alginate-based polycaprolactone copolymer and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811111447.0A CN109224118B (en) | 2018-09-23 | 2018-09-23 | Medical operation suture line |
Related Child Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011306603.6A Division CN112480420A (en) | 2018-09-23 | 2018-09-23 | Polyethylene glycol hydroxy acid modified polylactic acid beneficial to wound healing and application thereof |
| CN202011306632.2A Division CN112336911A (en) | 2018-09-23 | 2018-09-23 | Preparation method of medical surgical suture |
| CN202011311148.9A Division CN112430292A (en) | 2018-09-23 | 2018-09-23 | Antibacterial and degradable sodium alginate-based polycaprolactone copolymer and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109224118A true CN109224118A (en) | 2019-01-18 |
| CN109224118B CN109224118B (en) | 2021-11-16 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011311148.9A Withdrawn CN112430292A (en) | 2018-09-23 | 2018-09-23 | Antibacterial and degradable sodium alginate-based polycaprolactone copolymer and application thereof |
| CN202011306632.2A Withdrawn CN112336911A (en) | 2018-09-23 | 2018-09-23 | Preparation method of medical surgical suture |
| CN202011306603.6A Withdrawn CN112480420A (en) | 2018-09-23 | 2018-09-23 | Polyethylene glycol hydroxy acid modified polylactic acid beneficial to wound healing and application thereof |
| CN201811111447.0A Active CN109224118B (en) | 2018-09-23 | 2018-09-23 | Medical operation suture line |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202011311148.9A Withdrawn CN112430292A (en) | 2018-09-23 | 2018-09-23 | Antibacterial and degradable sodium alginate-based polycaprolactone copolymer and application thereof |
| CN202011306632.2A Withdrawn CN112336911A (en) | 2018-09-23 | 2018-09-23 | Preparation method of medical surgical suture |
| CN202011306603.6A Withdrawn CN112480420A (en) | 2018-09-23 | 2018-09-23 | Polyethylene glycol hydroxy acid modified polylactic acid beneficial to wound healing and application thereof |
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| Country | Link |
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| CN (4) | CN112430292A (en) |
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| CN110354298A (en) * | 2019-07-26 | 2019-10-22 | 南京聚屹新材料有限公司 | It is a kind of to be cross-linked in situ silver nanowires/polycaprolactone operation suture thread preparation method |
| CN111020841A (en) * | 2019-12-20 | 2020-04-17 | 顾正明 | Deodorant garment materials |
| IT201900002581A1 (en) * | 2019-02-22 | 2020-08-22 | Fondazione St Italiano Tecnologia | PROCESS FOR THE PREPARATION OF A COMPOSITE MATERIAL IN THE FORM OF FILAMENT, FILAMENT THUS OBTAINED AND ITS USE |
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| CN110354298A (en) * | 2019-07-26 | 2019-10-22 | 南京聚屹新材料有限公司 | It is a kind of to be cross-linked in situ silver nanowires/polycaprolactone operation suture thread preparation method |
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Also Published As
| Publication number | Publication date |
|---|---|
| CN112336911A (en) | 2021-02-09 |
| CN109224118B (en) | 2021-11-16 |
| CN112430292A (en) | 2021-03-02 |
| CN112480420A (en) | 2021-03-12 |
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