CN109223933A - A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria - Google Patents
A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria Download PDFInfo
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- CN109223933A CN109223933A CN201811398586.6A CN201811398586A CN109223933A CN 109223933 A CN109223933 A CN 109223933A CN 201811398586 A CN201811398586 A CN 201811398586A CN 109223933 A CN109223933 A CN 109223933A
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The present invention provides a kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria, it is related to field of Chinese medicinal composition, raw material including following parts by weight is made: 12-16 parts of rheum officinale, 6-9 parts of Radix Angelicae Sinensis, 7-10 parts of Radix Astragali, 8-14 parts of pearl powder, 7-11 parts of calamine, 7-10 parts of cow-bezoar, 5-10 parts of Radix Notoginseng, 3-10 parts of first pearl, 7-10 parts of Cortex Phellodendri, 5-12 parts of dragon's blood, 9-14 parts of carbonized hair, 11-14 parts of honeysuckle, 3-9 parts of polygonum cuspidate, 2-10 parts of field pennycress, 5-9 parts of olibanum water extract, topical cleansers prepared by the present invention can accelerate infective wound surface resume speed, help granulation tissue growth and wound healing, assist patient's early recovery.
Description
Technical field
The present invention relates to field of Chinese medicinal composition, and in particular to a kind of to treat in infective wound surface caused by multi-drug resistant bacteria
Medicine topical cleansers.
Background technique
Multi-drug resistant bacteria refers to the pathogen for having multi-drug resistant, specifically refers to a kind of microorganism to three classes or three classes
The above antibiotic while drug resistance, rather than three kinds of same class, in fact, as the unreasonable of antimicrobial uses and abuses,
Lead to being continuously increased for microorganism resistant rate.
Infective wound surface is clinically very common, when particularly occurring in wound, burn and postoperative wound healing
Phase, the surface of a wound are often difficult to heal, and increase the rehabilitation difficulty of patient.
A kind of external washout with traditional Chinese herbs agent for treating infective wound surface caused by multi-drug resistant bacteria of Publication No. CN105079404A,
For the multidrug resistant infective wound surface interpretation of the cause, onset and process of an illness, selection has activating microcirculation and removing stasis medicinal, heat-clearing and damp-drying drug, the Chinese medicine Thymifoious Euphorbia Herb removed necrosis and promoted granulation, takes off
Power grass, common bombax flower, Radix Seu Cortex Litseae Glutinosae, Ophiorrhiza japonica, red Herba Lycopi, Chinese squill, circaeashape loosestrife herb, nipponian greenbrier rhizome and root, are made lotion, try through clinic
It tests, total effective rate does not occur cross-infection up to 95%, significant in efficacy.
It is difficult to select effective antibiotics for causing the surface of a wound to generate multi-drug resistant bacteria due to abuse of antibiotics in treatment
The problem of, by matching traditional Chinese medicinal components, achievees the purpose that reduce surface of a wound pathogenic bacteria, but in its recipe ingredient be mostly hemostasia and detumescence
Component, can only passive sterilization be unable to reach wound healing and purpose.
Summary of the invention
(1) the technical issues of solving
In view of the deficiencies of the prior art, the present invention provides a kind of Chinese medicines for treating infective wound surface caused by multi-drug resistant bacteria
Topical cleansers can accelerate infective wound surface resume speed, help patient's early recovery.
(2) technical solution
In order to achieve the above object, the present invention is achieved by the following technical programs:
A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria, the original including following parts by weight
Material is made: 12-16 parts of rheum officinale, 6-9 parts of Radix Angelicae Sinensis, 7-10 parts of Radix Astragali, 8-14 parts of pearl powder, 7-11 parts of calamine, 7-10 parts of cow-bezoar,
5-10 parts of Radix Notoginseng, 3-10 parts of first pearl, 7-10 parts of Cortex Phellodendri, 5-12 parts of dragon's blood, 9-14 parts of carbonized hair, 11-14 parts of honeysuckle, polygonum cuspidate 3-
9 parts, 2-10 parts of field pennycress, 5-9 parts of olibanum water extract.
Preferably, the raw material including following parts by weight is made: 13-15 parts of rheum officinale, 7-8 parts of Radix Angelicae Sinensis, 8-9 parts of Radix Astragali, treasure
11-13 parts of pearl powder, 9-10 parts of calamine, 8-9 parts of cow-bezoar, 5-9 parts of Radix Notoginseng, 5-8 parts of first pearl, 9-10 parts of Cortex Phellodendri, 7-11 parts of dragon's blood,
12-13 parts of carbonized hair, 12-14 parts of honeysuckle, 5-7 parts of polygonum cuspidate, 4-8 parts of field pennycress, 6-8 parts of olibanum water extract.
Preferably, the raw material including following parts by weight is made: 14 parts of rheum officinale, 7 parts of Radix Angelicae Sinensis, 9 parts of Radix Astragali, pearl powder 12
Part, 9 parts of calamine, 8 parts of cow-bezoar, 6 parts of Radix Notoginseng, 7 parts of first pearl, 9 parts of Cortex Phellodendri, 8 parts of dragon's blood, 12 parts of carbonized hair, 13 parts of honeysuckle, tiger
6 parts of cane, 5 parts of field pennycress, 7 parts of olibanum water extract.
The Chinese medicine external cleaning agent of infective wound surface caused by above-mentioned treatment multi-drug resistant bacteria, preparation method include following step
It is rapid:
(1) rheum officinale is taken according to weight ratio, Radix Angelicae Sinensis, Radix Astragali, cow-bezoar, Radix Notoginseng, Cortex Phellodendri, dragon's blood, honeysuckle, polygonum cuspidate, lose
Sauce grass is put into distilling kettle, and flow back boiling at 35-45 DEG C, is filtered under diminished pressure after the completion of boiling, is obtained mixture and mixed liquor A；
(2) pearl powder, calamine, first pearl, carbonized hair ball grinds are taken according to weight ratio, toppled over together with mixture
Enter in extractor, heat up Microwave Extraction after filling extraction solvent, after the completion of extraction, is filtered under diminished pressure to obtain mixed liquor, residue is made
It is squeezed in fuel-displaced addition mixed liquor with expeller and obtains mixed liquid B；
(3) it will be concentrated in vacuo in mixed liquor A and mixed liquid B, olibanum water extract injection vacuum concentration pan, through ultrafiltration membrane mistake
Final product is obtained after filter.
Preferably, extraction solvent described in step (2) is ethyl alcohol, and the ethyl alcohol is 50% ethyl alcohol of 9 times of volumes of raw material.
Preferably, the temperature of heating described in step (2) is 60-70 DEG C.
Preferably, which is characterized in that the membrane aperture of ultrafiltration membrane described in step (3) is between 0.03-0.07um, operation pressure
Power is between 0.3MPa-0.5MPa.
(3) beneficial effect
The present invention provides a kind of Chinese medicine external cleaning agents for treating infective wound surface caused by multi-drug resistant bacteria, have following
The utility model has the advantages that
Firstly, pearl powder, calamine increase the deposition of calcium, phosphorus in bone matrix, has to the healing of the undisguised surface of a wound and promote
Into effect.
Though it can promote in wound ester in macrophage secondly, cow-bezoar, field pennycress be without direct sterilization and bacteriostasis effect
The content of enzyme enhances the phagocytic activity of leucocyte, accelerates the absorption and excretion of Inflammatory substances, and endogenous growth is attracted therefore to create
Face aggregation helps granulation tissue growth and wound healing.
Finally, the present invention helps blood capillary proliferation, excites physical function pair by optimization formula, regulation formula rate
In the decomposition of necrotic tissue, while promoting the growth of fresh granulation, suitable for because the surface of a wound is difficult to caused by multi-drug resistant bacteria
The problem of healing.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention,
Technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is the present invention one
Divide embodiment, instead of all the embodiments.Based on the embodiments of the present invention, those of ordinary skill in the art are not making
Every other embodiment obtained, shall fall within the protection scope of the present invention under the premise of creative work.
Embodiment 1:
A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria, the original including following parts by weight
Material is made: 16 parts of rheum officinale, 6 parts of Radix Angelicae Sinensis, 10 parts of Radix Astragali, 8 parts of pearl powder, 11 parts of calamine, 7 parts of cow-bezoar, 5 parts of Radix Notoginseng, first pearl 10
Part, 7 parts of Cortex Phellodendri, 12 parts of dragon's blood, 9 parts of carbonized hair, 14 parts of honeysuckle, 3 parts of polygonum cuspidate, 10 parts of field pennycress, 5 parts of olibanum water extract.
The Chinese medicine external cleaning agent of infective wound surface caused by above-mentioned treatment multi-drug resistant bacteria, preparation method include following step
It is rapid:
(1) rheum officinale is taken according to weight ratio, Radix Angelicae Sinensis, Radix Astragali, cow-bezoar, Radix Notoginseng, Cortex Phellodendri, dragon's blood, honeysuckle, polygonum cuspidate, lose
Sauce grass is put into distilling kettle, and flow back boiling at 45 DEG C, is filtered under diminished pressure after the completion of boiling, is obtained mixture and mixed liquor A；
(2) pearl powder, calamine, first pearl, carbonized hair ball grinds are taken according to weight ratio, toppled over together with mixture
Enter in extractor, filling is warming up to 60 DEG C after extracting solvent (50% ethyl alcohol of 9 times of volumes of raw material), and Microwave Extraction is extracted and completed
Afterwards, it is filtered under diminished pressure to obtain mixed liquor, residue is squeezed in fuel-displaced addition mixed liquor using expeller and obtains mixed liquid B；
(3) it will be concentrated in vacuo in mixed liquor A and mixed liquid B, olibanum water extract injection vacuum concentration pan, through ultrafiltration membrane
(membrane aperture 0.07um) is filtered when controlling operating pressure and being 0.3MPa, and final product is obtained after the completion of filtering.
Embodiment 2:
A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria, the original including following parts by weight
Material is made: 12 parts of rheum officinale, 9 parts of Radix Angelicae Sinensis, 7 parts of Radix Astragali, 14 parts of pearl powder, 7 parts of calamine, 10 parts of cow-bezoar, 10 parts of Radix Notoginseng, first pearl 3
Part, 10 parts of Cortex Phellodendri, 5 parts of dragon's blood, 14 parts of carbonized hair, 11 parts of honeysuckle, 9 parts of polygonum cuspidate, 2 parts of field pennycress, 9 parts of olibanum water extract.
The Chinese medicine external cleaning agent of infective wound surface caused by above-mentioned treatment multi-drug resistant bacteria, preparation method include following step
It is rapid:
(1) rheum officinale is taken according to weight ratio, Radix Angelicae Sinensis, Radix Astragali, cow-bezoar, Radix Notoginseng, Cortex Phellodendri, dragon's blood, honeysuckle, polygonum cuspidate, lose
Sauce grass is put into distilling kettle, and flow back boiling at 35 DEG C, is filtered under diminished pressure after the completion of boiling, is obtained mixture and mixed liquor A；
(2) pearl powder, calamine, first pearl, carbonized hair ball grinds are taken according to weight ratio, toppled over together with mixture
Enter in extractor, filling is warming up to 70 DEG C after extracting solvent (50% ethyl alcohol of 9 times of volumes of raw material), and Microwave Extraction is extracted and completed
Afterwards, it is filtered under diminished pressure to obtain mixed liquor, residue is squeezed in fuel-displaced addition mixed liquor using expeller and obtains mixed liquid B；
(3) it will be concentrated in vacuo in mixed liquor A and mixed liquid B, olibanum water extract injection vacuum concentration pan, through ultrafiltration membrane
(membrane aperture 0.03um) is filtered when controlling operating pressure and being 0.5MPa, and final product is obtained after the completion of filtering.
Embodiment 3:
A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria, the original including following parts by weight
Material is made: 15 parts of rheum officinale, 7 parts of Radix Angelicae Sinensis, 9 parts of Radix Astragali, 11 parts of pearl powder, 10 parts of calamine, 8 parts of cow-bezoar, 9 parts of Radix Notoginseng, first pearl 8
Part, 9 parts of Cortex Phellodendri, 7 parts of dragon's blood, 13 parts of carbonized hair, 14 parts of honeysuckle, 5 parts of polygonum cuspidate, 8 parts of field pennycress, 6 parts of olibanum water extract.
The Chinese medicine external cleaning agent of infective wound surface caused by above-mentioned treatment multi-drug resistant bacteria, preparation method include following step
It is rapid:
(1) rheum officinale is taken according to weight ratio, Radix Angelicae Sinensis, Radix Astragali, cow-bezoar, Radix Notoginseng, Cortex Phellodendri, dragon's blood, honeysuckle, polygonum cuspidate, lose
Sauce grass is put into distilling kettle, and flow back boiling at 36 DEG C, is filtered under diminished pressure after the completion of boiling, is obtained mixture and mixed liquor A；
(2) pearl powder, calamine, first pearl, carbonized hair ball grinds are taken according to weight ratio, toppled over together with mixture
Enter in extractor, filling is warming up to 65 DEG C after extracting solvent (50% ethyl alcohol of 9 times of volumes of raw material), and Microwave Extraction is extracted and completed
Afterwards, it is filtered under diminished pressure to obtain mixed liquor, residue is squeezed in fuel-displaced addition mixed liquor using expeller and obtains mixed liquid B；
(3) it will be concentrated in vacuo in mixed liquor A and mixed liquid B, olibanum water extract injection vacuum concentration pan, through ultrafiltration membrane
(membrane aperture 0.05um) is filtered when controlling operating pressure and being 0.4MPa, and final product is obtained after the completion of filtering.
Embodiment 4:
A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria, the original including following parts by weight
Material is made: 13 parts of rheum officinale, 8 parts of Radix Angelicae Sinensis, 8 parts of Radix Astragali, 13 parts of pearl powder, 9 parts of calamine, 9 parts of cow-bezoar, 5 parts of Radix Notoginseng, 5 parts of first pearl,
10 parts of Cortex Phellodendri, 11 parts of dragon's blood, 12 parts of carbonized hair, 12 parts of honeysuckle, 7 parts of polygonum cuspidate, 4 parts of field pennycress, 8 parts of olibanum water extract.
The Chinese medicine external cleaning agent of infective wound surface caused by above-mentioned treatment multi-drug resistant bacteria, preparation method include following step
It is rapid:
(1) rheum officinale is taken according to weight ratio, Radix Angelicae Sinensis, Radix Astragali, cow-bezoar, Radix Notoginseng, Cortex Phellodendri, dragon's blood, honeysuckle, polygonum cuspidate, lose
Sauce grass is put into distilling kettle, and flow back boiling at 40 DEG C, is filtered under diminished pressure after the completion of boiling, is obtained mixture and mixed liquor A；
(2) pearl powder, calamine, first pearl, carbonized hair ball grinds are taken according to weight ratio, toppled over together with mixture
Enter in extractor, filling is warming up to 66 DEG C after extracting solvent (50% ethyl alcohol of 9 times of volumes of raw material), and Microwave Extraction is extracted and completed
Afterwards, it is filtered under diminished pressure to obtain mixed liquor, residue is squeezed in fuel-displaced addition mixed liquor using expeller and obtains mixed liquid B；
(3) it will be concentrated in vacuo in mixed liquor A and mixed liquid B, olibanum water extract injection vacuum concentration pan, through ultrafiltration membrane
(membrane aperture 0.06um) is filtered when controlling operating pressure and being 0.35MPa, and final product is obtained after the completion of filtering.
Embodiment 5:
A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria, the original including following parts by weight
Material is made: 14 parts of rheum officinale, 7 parts of Radix Angelicae Sinensis, 9 parts of Radix Astragali, 12 parts of pearl powder, 9 parts of calamine, 8 parts of cow-bezoar, 6 parts of Radix Notoginseng, 7 parts of first pearl,
9 parts of Cortex Phellodendri, 8 parts of dragon's blood, 12 parts of carbonized hair, 13 parts of honeysuckle, 6 parts of polygonum cuspidate, 5 parts of field pennycress, 7 parts of olibanum water extract.
The Chinese medicine external cleaning agent of infective wound surface caused by above-mentioned treatment multi-drug resistant bacteria, preparation method include following step
It is rapid:
(1) rheum officinale is taken according to weight ratio, Radix Angelicae Sinensis, Radix Astragali, cow-bezoar, Radix Notoginseng, Cortex Phellodendri, dragon's blood, honeysuckle, polygonum cuspidate, lose
Sauce grass is put into distilling kettle, and flow back boiling at 42 DEG C, is filtered under diminished pressure after the completion of boiling, is obtained mixture and mixed liquor A；
(2) pearl powder, calamine, first pearl, carbonized hair ball grinds are taken according to weight ratio, toppled over together with mixture
Enter in extractor, filling is warming up to 66 DEG C after extracting solvent (50% ethyl alcohol of 9 times of volumes of raw material), and Microwave Extraction is extracted and completed
Afterwards, it is filtered under diminished pressure to obtain mixed liquor, residue is squeezed in fuel-displaced addition mixed liquor using expeller and obtains mixed liquid B；
(3) it will be concentrated in vacuo in mixed liquor A and mixed liquid B, olibanum water extract injection vacuum concentration pan, through ultrafiltration membrane
(membrane aperture 0.06um) is filtered when controlling operating pressure and being 0.45MPa, and final product is obtained after the completion of filtering.
Embodiment 6:
A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria, the original including following parts by weight
Material is made: 14 parts of rheum officinale, 6 parts of Radix Angelicae Sinensis, 10 parts of Radix Astragali, 11 parts of pearl powder, 10 parts of calamine, 9 parts of cow-bezoar, 7 parts of Radix Notoginseng, first pearl 8
Part, 9 parts of Cortex Phellodendri, 11 parts of dragon's blood, 13 parts of carbonized hair, 12 parts of honeysuckle, 7 parts of polygonum cuspidate, 4 parts of field pennycress, 7 parts of olibanum water extract.
The Chinese medicine external cleaning agent of infective wound surface caused by above-mentioned treatment multi-drug resistant bacteria, preparation method include following step
It is rapid:
(1) rheum officinale is taken according to weight ratio, Radix Angelicae Sinensis, Radix Astragali, cow-bezoar, Radix Notoginseng, Cortex Phellodendri, dragon's blood, honeysuckle, polygonum cuspidate, lose
Sauce grass is put into distilling kettle, and flow back boiling at 42 DEG C, is filtered under diminished pressure after the completion of boiling, is obtained mixture and mixed liquor A；
(2) pearl powder, calamine, first pearl, carbonized hair ball grinds are taken according to weight ratio, toppled over together with mixture
Enter in extractor, filling is warming up to 62 DEG C after extracting solvent (50% ethyl alcohol of 9 times of volumes of raw material), and Microwave Extraction is extracted and completed
Afterwards, it is filtered under diminished pressure to obtain mixed liquor, residue is squeezed in fuel-displaced addition mixed liquor using expeller and obtains mixed liquid B；
(3) it will be concentrated in vacuo in mixed liquor A and mixed liquid B, olibanum water extract injection vacuum concentration pan, through ultrafiltration membrane
(membrane aperture 0.06um) is filtered when controlling operating pressure and being 0.39MPa, and final product is obtained after the completion of filtering.
Beneficial effect in order to further illustrate the present invention, selects 40 rabbit modelings, and every rabbit is cooked 4 at back
The identical infective wound surface of diameter, randomly selecting 20 rabbits is one group, respectively treatment group, control group, selects the present invention real
It applies a finished product for 1-5 preparation and carries out 2 cleanings daily to treatment group rabbit, respectively to two groups of hare infections after 15d and 30d
The reparation situation of the surface of a wound is recorded, and result is recorded in following table.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.In the absence of more restrictions, including the element that sentence "including a ..." limits, it is not excluded that
There is also other identical elements in the process, method, article or apparatus that includes the element.
The above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations, although with reference to the foregoing embodiments
Invention is explained in detail, those skilled in the art should understand that: it still can be to aforementioned each implementation
Technical solution documented by example is modified or equivalent replacement of some of the technical features；And these modification or
Replacement, the spirit and scope for technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution.
Claims (7)
1. a kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria, which is characterized in that including following heavy
Amount number raw material be made: 12-16 parts of rheum officinale, 6-9 parts of Radix Angelicae Sinensis, 7-10 parts of Radix Astragali, 8-14 parts of pearl powder, 7-11 parts of calamine,
7-10 parts of cow-bezoar, 5-10 parts of Radix Notoginseng, 3-10 parts of first pearl, 7-10 parts of Cortex Phellodendri, 5-12 parts of dragon's blood, 9-14 parts of carbonized hair, honeysuckle 11-
14 parts, 3-9 parts of polygonum cuspidate, 2-10 parts of field pennycress, 5-9 parts of olibanum water extract.
2. the Chinese medicine external cleaning agent of infective wound surface caused by treatment multi-drug resistant bacteria, feature exist as described in claim 1
In the raw material including following parts by weight is made: 13-15 parts of rheum officinale, 7-8 parts of Radix Angelicae Sinensis, 8-9 parts of Radix Astragali, 11-13 parts of pearl powder,
9-10 parts of calamine, 8-9 parts of cow-bezoar, 5-9 parts of Radix Notoginseng, 5-8 parts of first pearl, 9-10 parts of Cortex Phellodendri, 7-11 parts of dragon's blood, carbonized hair 12-13
Part, 12-14 parts of honeysuckle, 5-7 parts of polygonum cuspidate, 4-8 parts of field pennycress, 6-8 parts of olibanum water extract.
3. the Chinese medicine external cleaning agent of infective wound surface caused by treatment multi-drug resistant bacteria, feature exist as described in claim 1
In the raw material including following parts by weight is made: 14 parts of rheum officinale, 7 parts of Radix Angelicae Sinensis, 9 parts of Radix Astragali, 12 parts of pearl powder, 9 parts of calamine,
8 parts of cow-bezoar, 6 parts of Radix Notoginseng, 7 parts of first pearl, 9 parts of Cortex Phellodendri, 8 parts of dragon's blood, 12 parts of carbonized hair, 13 parts of honeysuckle, 6 parts of polygonum cuspidate, field pennycress 5
Part, 7 parts of olibanum water extract.
4. the Chinese medicine external cleaning agent of infective wound surface caused by treatment multi-drug resistant bacteria, feature exist as described in claim 1
In, preparation method the following steps are included:
(1) rheum officinale, Radix Angelicae Sinensis, Radix Astragali, cow-bezoar, Radix Notoginseng, Cortex Phellodendri, dragon's blood, honeysuckle, polygonum cuspidate, field pennycress are taken according to weight ratio
It is put into distilling kettle, flow back boiling at 35-45 DEG C, is filtered under diminished pressure after the completion of boiling, obtains mixture and mixed liquor A；
(2) pearl powder, calamine, first pearl, carbonized hair ball grinds are taken according to weight ratio, pours into and mentions together with mixture
It takes in tank, heat up Microwave Extraction after filling extraction solvent, after the completion of extraction, is filtered under diminished pressure to obtain mixed liquor, residue is used spiral shell
Rotating squeezer squeezes in fuel-displaced addition mixed liquor and obtains mixed liquid B；
(3) it will be concentrated in vacuo in mixed liquor A and mixed liquid B, olibanum water extract injection vacuum concentration pan, after ultrafiltration membrance filter i.e.
Obtain final product.
5. the Chinese medicine external cleaning agent of infective wound surface caused by treatment multi-drug resistant bacteria, feature exist as claimed in claim 4
In extraction solvent described in step (2) is ethyl alcohol, and the ethyl alcohol is 50% ethyl alcohol of 9 times of volumes of raw material.
6. the Chinese medicine external cleaning agent of infective wound surface caused by treatment multi-drug resistant bacteria, feature exist as claimed in claim 4
In the temperature of heating described in step (2) is 60-70 DEG C.
7. the Chinese medicine external cleaning agent of infective wound surface caused by treatment multi-drug resistant bacteria, feature exist as claimed in claim 4
In the membrane aperture of ultrafiltration membrane described in step (3) is between 0.03-0.07um, and operating pressure is between 0.3MPa-0.5MPa.
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| CN201811398586.6A CN109223933A (en) | 2018-11-22 | 2018-11-22 | A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201811398586.6A CN109223933A (en) | 2018-11-22 | 2018-11-22 | A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108686101A (en) * | 2018-07-30 | 2018-10-23 | 王解生 | A kind of herbal composite promoting organization healing |
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| CN1670160A (en) * | 2005-04-16 | 2005-09-21 | 王浩贵 | Phellodendron bark cleaning products |
| CN102091134A (en) * | 2011-01-12 | 2011-06-15 | 刘清泉 | Traditional Chinese medicinal composition for resisting multi-medicine tolerance of antibiotics |
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| CN108686101A (en) * | 2018-07-30 | 2018-10-23 | 王解生 | A kind of herbal composite promoting organization healing |
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