CN102091134A - Traditional Chinese medicinal composition for resisting multi-medicine tolerance of antibiotics - Google Patents
Traditional Chinese medicinal composition for resisting multi-medicine tolerance of antibiotics Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicinal composition for resisting the multi-medicine tolerance of antibiotics, which is prepared from raw material medicaments such as raw astragalus, Chinese angelica, honeysuckle, sweet wormwood herb, giant knotweed rhizome and the like. Medicament-containing serum of the Chinese medicinal composition can be used as 'a sensitizer' of the antibiotics to reduce the medicine tolerant degree of medicine tolerant bacteria on the antibiotics so as to enhance the curative effect of the antibiotics, reduce the use of the antibiotics and shorten the use time of the antibiotics.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, the multidrug resistant Chinese medicine composition of particularly a kind of anti-antibiotics.
Background technology
In recent years because third generation cephalosporin and the extensive use clinically of carbapenem antibiotics, Pseudomonas aeruginosa obviously increases the drug resistance of beta-lactam enzyme and carbapenem antibiotics, the recall rate of multidrug resistant and general Resistant strain constantly increases, and it all occupy the top priority in investigation of various big hospital antibacterial separation rate at home.
Pseudomonas aeruginosa (PA) has stronger quick adaptive capacity, its mechanism that produces multi-drug resistant is complicated, to the synergistic result of several often mechanism of the drug resistance of a certain class antibacterials, resistance mechanism to different antibacterials is also incomplete same, but also constantly there is new resistance mechanism to occur, present known resistance mechanism mainly contains: (1) produces purifying enzyme, as beta-lactamase, aminoglycoside modification enzyme etc.; (2) gene mutation is as the sudden change of DNA topoisomerase and DNA gyrase, the overexpression etc. of efflux pump system initiatively; (3) biofilm; (4) dna mismatch repair system.
The unreasonable use of antibiotics is the root of bacterial resistance, therefore, no matter is polymyxin or multiple antibiotics use in conjunction at present, still researches and develops novel anti rhzomorph etc. and all can not effectively solve the bacterial resistance problem.Modern pharmacology studies show that the Chinese medicine antipathogenic composition is more, can act on the different parts of antibacterial and the different phase of breeding, and a plurality of metabolism links of antibacterial are played a role, so be difficult for producing drug resistance.Based on Chinese medicine anti-infective historical experience and advantage, in recent years studies show that aspect the Chinese medicine drug-fast bacteria infection, Chinese medicine has the effect that suppresses fastbacteria, and it is can reverse bacterial drug resistance, but less to the research of the synergy between Chinese medicine and the antibiotics at present at some resistance mechanism.
Summary of the invention
The object of the present invention is to provide the multidrug resistant Chinese medicine composition of a kind of anti-antibiotics, another object of the present invention is to provide a kind of kit with antibacterial action.
The objective of the invention is to be achieved through the following technical solutions:
The multidrug resistant Chinese medicine composition of a kind of anti-antibiotics provided by the invention is to be made by following crude drug:
Radix Astragali 30-120 weight portion Radix Angelicae Sinensis 5-20 weight portion
Flos Lonicerae 10-25 weight portion Herba Artemisiae Annuae 10-30 weight portion
Rhizoma Polygoni Cuspidati 5-20 weight portion.
Above-mentioned Chinese medicine composition is preferably made by following crude drug:
Radix Astragali 50-100 weight portion Radix Angelicae Sinensis 8-15 weight portion
Flos Lonicerae 10-25 weight portion Herba Artemisiae Annuae 10-30 weight portion
Rhizoma Polygoni Cuspidati 5-20 weight portion.
Above-mentioned Chinese medicine composition is preferably made by following crude drug:
Radix Astragali 80 weight portion Radix Angelicae Sinensis 15 weight portions
Flos Lonicerae 20 weight portion Herba Artemisiae Annuaes 20 weight portions
Rhizoma Polygoni Cuspidati 10 weight portions.
Above-mentioned Chinese medicine composition is preferably made by following crude drug::
Radix Astragali 50 weight portion Radix Angelicae Sinensis 18 weight portions
Flos Lonicerae 24 weight portion Herba Artemisiae Annuaes 15 weight portions
Rhizoma Polygoni Cuspidati 6 weight portions.
Above-mentioned Chinese medicine composition is preferably made by following crude drug::
Radix Astragali 110 weight portion Radix Angelicae Sinensis 8 weight portions
Flos Lonicerae 15 weight portion Herba Artemisiae Annuaes 28 weight portions
Rhizoma Polygoni Cuspidati 18 weight portions.
Above-mentioned Chinese medicine composition adds conventional adjuvant, according to common process, makes various dosage forms such as pharmaceutically acceptable water decoction, capsule, tablet, pill, oral liquid, injection, powder.
Described common process method comprises water extraction or alcohol extraction or first water extraction water extraction again after alcohol extraction or the first alcohol extraction again; It is further active constituent-enriched to cross macroporous resin column after above-mentioned conventional the extraction.
For above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.For making above-mentioned dosage form can realize pharmacy of Chinese materia medica, need when these dosage forms of preparation, to add acceptable other adjuvant of pharmacy (adjuvant of each dosage form record among the Fan Biting " pharmacy of Chinese materia medica ", Shanghai Science Press December in 1997 the 1st edition).
A kind of kit with antibacterial action is provided, and this kit is made up of Chinese medicine preparation and a kind of antibiotic preparation of the daily dosage of unit; Described Chinese medicine preparation is made by following crude drug:
Radix Astragali 30-120 weight portion Radix Angelicae Sinensis 5-20 weight portion
Flos Lonicerae 10-25 weight portion Herba Artemisiae Annuae 10-30 weight portion
Rhizoma Polygoni Cuspidati 5-20 weight portion.
In the preferred ceftazidime of described antibiotics, cefoperzone sodium and sulbactam sodium or the imipenem cilastatin sodium any one.
Chinese medicine composition of the present invention our experiments show that, ceftazidime, three kinds of antibiotics associating Chinese medicine composition pastilles of the present invention of cefoperzone sodium and sulbactam sodium and imipenem cilastatin sodium serum has evident difference with single with the external fungistatic effect of antibiotics, pastille serum can effectively reduce the MIC of above-mentioned three kinds of antibiotics, the MBC value, it is antibacterial to strengthen it, bactericidal action, Chinese medicine composition pastille serum of the present invention can be as " sensitizer " of antibiotics, reduce the drug-resistant intensity of fastbacteria to antibiotics, thereby strengthen the curative effect of antibiotics, reduce the use of antibiotics, shorten the service time of antibiotics.
Following experimental example and embodiment further prove but are not limited to the present invention.
Experimental example 1: the external intervention multidrug resistant of Chinese medicine composition associating antibiotics of the present invention Pseudomonas aeruginosa experiment
1 material
1.1 medicine: Chinese medicine composition water decoction of the present invention (pressing the preparation of embodiment 1 method) (2.0g/ml), is provided by Beijing University Of Chinese Medicine Traditional Chinese Medicine College's TCM Research Office; Ceftazidime (the batch number E20100102 of Shenzhen Zhijun Pharmaceutical Co., Ltd), cefoperzone sodium and sulbactam sodium (pfizer inc is produced batch number 1039098), imipenem cilastatin sodium (Merck﹠amp; Co., Inc.USA batch number 100231), all, be mixed with the solution of 512 μ g/ml, 1024 μ g/ml (amount with cefoperazone is calculated) and 256 μ g/ml (amount with imipenum is calculated) respectively with normal saline available from Pharmacy department of Dongzhimen Hospital, Beijing Univ of Traditional Chinese Medicine.
1.2 animal: 16 of SD rats, the cleaning level, body weight 200～220g, available from Test Animal Centre, Academy of Military Medical Sciences, P.L.A, quality certification SCXK-(army) 2007-004.Under the normal illumination condition, food, water can freely absorb, and room temperature is controlled between 18 ℃-22 ℃.
1.3 bacterial strain: No. 1643, multidrug resistant Pseudomonas aeruginosa clinical separation strain is provided by the ZhaoYang Hospital Bacteriology Room.
1.4 reagent and equipment: M-H broth bouillon, disposable sterilized 24 orifice plates, sample injector, superclean bench (available from Beijing green all cleaning equipments company limited), vertical automatic electric heating pressure steam sterilizer (ATELL AMA440N), constant incubator (SAMYO SIM-F124), low-temperature and high-speed centrifuge (Kendro Labofuge 400R), microbalance (METTLER AE100).
2 methods
2.1 the SD rat is divided into blank group, 8 times of dose,equivalent groups of Chinese medicine composition water decoction of the present invention at random, every group each 8, gives distilled water and Chinese medicine composition water decoction of the present invention (2.0g/ml) respectively and irritate stomach, every day twice, each 4ml, totally 5 days, 1h after the last administration gives 10% chloral hydrate solution with each group rat, presses 0.4ml/100g, behind the intraperitoneal injection of anesthesia, the ventral aorta blood sampling, 4 ℃ are centrifugal, 2500r, 20min, aseptic separation of serum is with 8 rat blood serum mixing for standby use of each group.
2.2 with antibiotics solution respectively with blank serum, pastille serum mixes at 1: 1, in 24 orifice plates, add M-H broth bouillon 1ml, add blank serum respectively at first hole of every group again, 8 times of dose,equivalent pastille serum, ceftazidime solution, cefoperzone sodium and sulbactam sodium solution, the imipenem cilastatin sodium solution, ceftazidime+blank serum mixed solution, cefoperzone sodium and sulbactam sodium+blank serum mixed solution, the blank serum mixed solution of imipenem cilastatin sodium, ceftazidime+pastille serum mixed solution, cefoperzone sodium and sulbactam sodium+pastille serum mixed solution, imipenem cilastatin sodium+pastille serum mixed solution 1ml, adopt doubling dilution with each hole two-fold dilution successively, final each reaction system is 1ml, will contain the bacterium liquid (5 * 10 of fluid medium again
7CFU/ml) get 10ul and add in each hole, 37 ℃, hatch 18-24h.Transferred species 37 ℃, is hatched 18-24h to the culture dish that contains the M-H agar culture medium respectively then.
3 results
3.1 the pastille serum that gives to obtain behind 8 times of dose,equivalents of rat Chinese medicine composition water decoction filling of the present invention stomach has external bacteriostasis.The blank serum that gives to obtain behind the rat distilled water filling stomach does not have external bacteriostasis.See Table 1.
Blank serum of table 1 and pastille serum are to the bacteriostasis of multidrug resistant Pseudomonas aeruginosa
3.2 detection index: minimum inhibitory concentration MIC, minimum bactericidal concentration MBC;
Simple ceftazidime does not still have bacteriostasis at 256 μ g/ml, and ceftazidime minimum inhibitory concentration MIC value is 64 μ g/m behind the associating pastille serum; Simple imipenem cilastatin sodium MIC value is 32 μ g/ml, reduces to 16 μ g/ml after uniting pastille serum, and concentration becomes sterilization by antibacterial when being 32 μ g/ml; Simple cefoperzone sodium and sulbactam sodium MIC value is 64 μ g/ml, unites behind the pastille serum by antibacterial to become sterilization.Selected antibiotics is united the external bacteriostasis zero difference of blank serum and simple antibiotics.See Table 2.
Simple antibiotics of table 2 and antibiotics associating serum are to MIC, the MBC value of multidrug resistant Pseudomonas aeruginosa
Annotate: antibiotics associating serum is the concentration of antibiotics in its reaction system to MIC, the MBC value of multidrug resistant Pseudomonas aeruginosa.
3.3 the drug sensitive experiment result shows that the Pseudomonas aeruginosa after pastille serum group and imipenem cilastatin sodium+pastille serum group transferred species is an intermediary to the cefoperzone sodium and sulbactam sodium drug resistance, the MIC value is 32 μ g/ml, to other antibiotics drug resistances.All the other respectively organize Pseudomonas aeruginosa after the transferred species to the equal drug resistance of the used antibiotics of drug sensitive test, and are consistent with the drug sensitivity tests of experimental strain.
Following embodiment all can realize the effect of above-mentioned experimental example.
The specific embodiment
Embodiment 1: water decoction
Radix Astragali 80g Radix Angelicae Sinensis 15g
Flos Lonicerae 20g Herba Artemisiae Annuae 20g
Rhizoma Polygoni Cuspidati 10g
Get the above-mentioned raw materials medicine, decoct with water 2 times, amount of water is a conventional amount used, merges aqueous extract, makes water decoction.
Embodiment 2: tablet
Radix Astragali 50g Radix Angelicae Sinensis 18g
Flos Lonicerae 24g Herba Artemisiae Annuae 15g
Rhizoma Polygoni Cuspidati 6g
Get the above-mentioned raw materials medicine, add alcohol at normal temperature and flooded 24 hours down, merge extractive liquid, reclaims ethanol, and concentrate drying adds conventional adjuvant, according to common process, makes tablet.
Embodiment 3: capsule
Radix Astragali 110g Radix Angelicae Sinensis 8g
Flos Lonicerae 15g Herba Artemisiae Annuae 28g
Rhizoma Polygoni Cuspidati 18g
Get the above-mentioned raw materials medicine, add ethanol to 10 times of medical material amount and carry out percolation, reclaim ethanol, concentrate drying adds conventional adjuvant, according to common process, makes capsule.
Embodiment 4: oral liquid
Radix Astragali 40g Radix Angelicae Sinensis 20g
Flos Lonicerae 22g Herba Artemisiae Annuae 12g
Rhizoma Polygoni Cuspidati 8g
Get the above-mentioned raw materials medicine,, make oral liquid according to common process.
Embodiment 5: injection
Radix Astragali 100g Radix Angelicae Sinensis 10g
Flos Lonicerae 12g Herba Artemisiae Annuae 25g
Rhizoma Polygoni Cuspidati 15g
Get the above-mentioned raw materials medicine, add water extraction 3 times, each 1 hour, merging filtrate, concentrate drying adds conventional adjuvant, according to common process, makes injection.
Embodiment 6: granule
Radix Astragali 90g Radix Angelicae Sinensis 15g
Flos Lonicerae 15g Herba Artemisiae Annuae 25g
Rhizoma Polygoni Cuspidati 15g
Get the above-mentioned raw materials medicine, add water extraction 3 times, each 1 hour, merging filtrate, concentrate drying adds conventional adjuvant, according to common process, makes granule.
Claims (9)
1. multidrug resistant Chinese medicine composition of anti-antibiotics is characterized in that this Chinese medicine composition made by following crude drug:
Radix Astragali 30-120 weight portion Radix Angelicae Sinensis 5-20 weight portion
Flos Lonicerae 10-25 weight portion Herba Artemisiae Annuae 10-30 weight portion
Rhizoma Polygoni Cuspidati 5-20 weight portion.
2. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following crude drug:
Radix Astragali 50-100 weight portion Radix Angelicae Sinensis 8-15 weight portion
Flos Lonicerae 10-25 weight portion Herba Artemisiae Annuae 10-30 weight portion
Rhizoma Polygoni Cuspidati 5-20 weight portion.
3. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following crude drug:
Radix Astragali 80 weight portion Radix Angelicae Sinensis 15 weight portions
Flos Lonicerae 20 weight portion Herba Artemisiae Annuaes 20 weight portions
Rhizoma Polygoni Cuspidati 10 weight portions; Perhaps
Radix Astragali 50 weight portion Radix Angelicae Sinensis 18 weight portions
Flos Lonicerae 24 weight portion Herba Artemisiae Annuaes 15 weight portions
Rhizoma Polygoni Cuspidati 6 weight portions.
4. Chinese medicine composition as claimed in claim 1 is characterized in that this Chinese medicine composition made by following crude drug:
Radix Astragali 110 weight portion Radix Angelicae Sinensis 8 weight portions
Flos Lonicerae 15 weight portion Herba Artemisiae Annuaes 28 weight portions
Rhizoma Polygoni Cuspidati 18 weight portions.
5. as the arbitrary described Chinese medicine composition of claim 1-4, it is characterized in that this Chinese medicine composition adds conventional adjuvant, according to common process, make pharmaceutically acceptable water decoction, capsule, tablet, pill, oral liquid, injection, the various dosage forms of granule.
6. kit with antibacterial action is characterized in that this kit is made up of Chinese medicine preparation and a kind of antibiotic preparation of the daily dosage of unit;
Described Chinese medicine preparation is made by following crude drug:
Radix Astragali 30-120 weight portion Radix Angelicae Sinensis 5-20 weight portion
Flos Lonicerae 10-25 weight portion Herba Artemisiae Annuae 10-30 weight portion
Rhizoma Polygoni Cuspidati 5-20 weight portion.
7. kit as claimed in claim 6 is characterized in that Chinese medicine preparation is made by following crude drug described in this kit:
Radix Astragali 80 weight portion Radix Angelicae Sinensis 15 weight portions
Flos Lonicerae 20 weight portion Herba Artemisiae Annuaes 20 weight portions
Rhizoma Polygoni Cuspidati 10 weight portions; Or
Radix Astragali 50 weight portion Radix Angelicae Sinensis 18 weight portions
Flos Lonicerae 24 weight portion Herba Artemisiae Annuaes 15 weight portions
Rhizoma Polygoni Cuspidati 6 weight portions; Or
Radix Astragali 110 weight portion Radix Angelicae Sinensis 8 weight portions
Flos Lonicerae 15 weight portion Herba Artemisiae Annuaes 28 weight portions
Rhizoma Polygoni Cuspidati 18 weight portions.
8. kit as claimed in claim 6 is characterized in that antibiotics described in this kit is any one in ceftazidime, cefoperzone sodium and sulbactam sodium or the imipenem cilastatin sodium.
9. has application in the medicine of anti-antibiotics multidrug resistant effect as the arbitrary described Chinese medicine composition of claim 1-4 in preparation.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102349896A (en) * | 2011-07-22 | 2012-02-15 | 广州定慧医药科技有限公司 | Pharmaceutical composition of imipenem, cilastatin and sulbactam |
| CN102379931A (en) * | 2011-11-17 | 2012-03-21 | 刘清泉 | Novel application of Chinese medicinal composition |
| CN102988456A (en) * | 2012-12-17 | 2013-03-27 | 河北神威药业有限公司 | Application of honeysuckle extractive from active components of Qingkailing for preparing multiple-resistant bacteria resistant medicine |
| CN104771747A (en) * | 2015-03-12 | 2015-07-15 | 成都乾坤动物药业有限公司 | Western medicine/traditional Chinese medicine composition for piglets and preparation method thereof |
| CN109223933A (en) * | 2018-11-22 | 2019-01-18 | 于方举 | A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria |
| CN115813980A (en) * | 2022-11-04 | 2023-03-21 | 北京中医药大学 | Application of pharmaceutical composition in preparation of pseudomonas aeruginosa drug-resistant strain biofilm inhibitor |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101116733A (en) * | 2006-08-04 | 2008-02-06 | 张立梅 | Medicinal pill for clearing away lung heat and treating pulmonary tuberculosis |
-
2011
- 2011-01-12 CN CN2011100055053A patent/CN102091134B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101116733A (en) * | 2006-08-04 | 2008-02-06 | 张立梅 | Medicinal pill for clearing away lung heat and treating pulmonary tuberculosis |
Non-Patent Citations (1)
| Title |
|---|
| 《新中医》 19861231 汤琢成 泽补汤治疗３５例类风湿性关节炎的体会 40－41 1－9 第18卷, 第2期 2 * |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102349896A (en) * | 2011-07-22 | 2012-02-15 | 广州定慧医药科技有限公司 | Pharmaceutical composition of imipenem, cilastatin and sulbactam |
| CN102349896B (en) * | 2011-07-22 | 2013-03-27 | 广州定慧医药科技有限公司 | Pharmaceutical composition of imipenem, cilastatin and sulbactam |
| CN102379931A (en) * | 2011-11-17 | 2012-03-21 | 刘清泉 | Novel application of Chinese medicinal composition |
| CN102988456A (en) * | 2012-12-17 | 2013-03-27 | 河北神威药业有限公司 | Application of honeysuckle extractive from active components of Qingkailing for preparing multiple-resistant bacteria resistant medicine |
| CN104771747A (en) * | 2015-03-12 | 2015-07-15 | 成都乾坤动物药业有限公司 | Western medicine/traditional Chinese medicine composition for piglets and preparation method thereof |
| CN104771747B (en) * | 2015-03-12 | 2018-01-05 | 成都乾坤动物药业有限公司 | A kind of piglet Chinese and western medicinal composition and preparation method thereof |
| CN109223933A (en) * | 2018-11-22 | 2019-01-18 | 于方举 | A kind of Chinese medicine external cleaning agent for treating infective wound surface caused by multi-drug resistant bacteria |
| CN115813980A (en) * | 2022-11-04 | 2023-03-21 | 北京中医药大学 | Application of pharmaceutical composition in preparation of pseudomonas aeruginosa drug-resistant strain biofilm inhibitor |
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