CN109222093A - A kind of water-soluble multi-nutrition additive and preparation and application with eye healthcare function - Google Patents
A kind of water-soluble multi-nutrition additive and preparation and application with eye healthcare function Download PDFInfo
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- CN109222093A CN109222093A CN201810994813.5A CN201810994813A CN109222093A CN 109222093 A CN109222093 A CN 109222093A CN 201810994813 A CN201810994813 A CN 201810994813A CN 109222093 A CN109222093 A CN 109222093A
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- Prior art keywords
- water
- parts
- lutein
- healthcare function
- soluble multi
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- 239000000654 additive Substances 0.000 title claims abstract description 36
- 230000000996 additive effect Effects 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 46
- 235000012680 lutein Nutrition 0.000 claims abstract description 44
- 229960005375 lutein Drugs 0.000 claims abstract description 44
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims abstract description 44
- 239000001656 lutein Substances 0.000 claims abstract description 44
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims abstract description 44
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims abstract description 44
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims abstract description 43
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 28
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 23
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 23
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 23
- 229940046009 vitamin E Drugs 0.000 claims abstract description 23
- 239000011709 vitamin E Substances 0.000 claims abstract description 23
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 20
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 20
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims abstract description 20
- 235000019441 ethanol Nutrition 0.000 claims abstract description 10
- -1 luteole Chemical compound 0.000 claims abstract description 10
- 230000008018 melting Effects 0.000 claims abstract description 9
- 238000002844 melting Methods 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims abstract description 4
- 229960000935 dehydrated alcohol Drugs 0.000 claims abstract description 3
- 229960004756 ethanol Drugs 0.000 claims abstract description 3
- 230000008014 freezing Effects 0.000 claims abstract description 3
- 238000007710 freezing Methods 0.000 claims abstract description 3
- 235000013305 food Nutrition 0.000 claims description 7
- 230000036541 health Effects 0.000 claims description 4
- 239000002537 cosmetic Substances 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 239000003814 drug Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 8
- 238000004040 coloring Methods 0.000 abstract description 4
- 238000001035 drying Methods 0.000 abstract description 2
- 239000013538 functional additive Substances 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 230000003078 antioxidant effect Effects 0.000 description 4
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 235000021466 carotenoid Nutrition 0.000 description 2
- 150000001747 carotenoids Chemical class 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 210000002189 macula lutea Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- KKAJSJJFBSOMGS-UHFFFAOYSA-N 3,6-diamino-10-methylacridinium chloride Chemical compound [Cl-].C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 KKAJSJJFBSOMGS-UHFFFAOYSA-N 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- 201000007737 Retinal degeneration Diseases 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 150000002658 luteins Chemical class 0.000 description 1
- 208000002780 macular degeneration Diseases 0.000 description 1
- 230000004483 macular pigment optical density Effects 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000000050 nutritive effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003711 photoprotective effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 210000001525 retina Anatomy 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000001052 yellow pigment Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/40—Colouring or decolouring of foods
- A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
- A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
- A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention belongs to functional additive field, a kind of water-soluble multi-nutrition additive with eye healthcare function and preparation and application are disclosed.The water-soluble multi-nutrition additive with eye healthcare function is grouped as by the group of following parts by weight: 1~5 part of lutein, 0.2~1 part of luteole, 1~5 part of vitamin E, 2~8 parts of hydroxypropyl-β-cyclodextrin, 82~95 parts of polyethylene glycol.Preparation method are as follows: precise lutein, luteole, vitamin E and hydroxypropyl-β-cyclodextrin, it is added in dehydrated alcohol and is uniformly mixed, after drying is evaporated completely ethyl alcohol, the polyethylene glycol of melting is added, it stirs evenly, it is placed in -4~-20 DEG C of 24~48h of freezing again, crushes up to product.The characteristics of present invention can enhance the water-soluble of lutein, have good water solubility, bright-colored, strong coloring force, application prospect is wide.
Description
Technical field
The invention belongs to functional additive fields, and in particular to a kind of water-soluble multi-nutrition with eye healthcare function adds
Add agent and preparation and application.
Background technique
Lutein (Lutein), also known as " Lutein " are a kind of oxygen containing carotenoid, are widely present in nature
In boundary, it is the natural yellow pigment of excellent natural and nonhazardous, cell and organ caused by oxygen radical can be resisted
Damage, early in nineteen ninety-five, U.S. FDA, that is, approved is used for food and drink as food supplement.Lutein is to the main of eyes
Physiological function is unique carotenoid composition that may exist eyes crystalline, is as antioxidant and photoprotection
The primary pigments and antioxidant content of macula retinae, many ophthalmology diseases all have much relations with the shortage of lutein, it is seen that
Lutein plays important protective effect for eyes.In the international market, the price of 1 gram of lutein is suitable with 1 gram of gold, so
People are referred to as " plant gold ".
Luteole belongs to oxygen containing carrotene with both lutein, the two isomer each other in structure,
It cannot be synthesized by human body itself, need exogenous intake.Luteole and vitamin E are all liposoluble vitamins, same to lutein
Powerful antioxidant is equally belonged to, can also protect body group by Anti-oxidation behaviors such as quenching singlet oxygen, removing free radicals
Cell is knitted, to protect biosystem from some potential illeffects caused by excessive oxidation reacts.It can prevent
The oxidation of lipid and vitamin in food, keeps the nutriment of food and flavor not to destroy because of oxidation, extends the guarantor of food
The fresh phase, thus luteole and vitamin E are very ideal Nanutal food fresh-keeping agents.
Lutein is fat-soluble carrotene, not soluble in water, although being distributed in the melon and fruit and vegetables of often feeding,
Absorptivity is generally lower, this characteristic determines that the application of lutein is very limited, and lutein made from the prior art
Product is there are not soluble in water, and it is poor that there are coloring effects, the low defect of bioavailability.
Summary of the invention
In place of the above shortcoming and defect of the existing technology, the primary purpose of the present invention is that providing one kind has
The water-soluble multi-nutrition additive of eye healthcare function.Water-soluble multi-nutrition additive of the invention makes leaf not soluble in water
Flavine is solvable, and has strong coloring force, and bright-colored feature is added to beverage, health care product, skin care item as additive
In, lutein defect not soluble in water itself had both been compensated for, has expanded application range, and nutritive value with higher and eye are protected
Health-care function and stronger antioxidant activity, meet food additives " natural ", " nutrition ", " multi-functional " developing direction.
Another object of the present invention is to provide the systems of the above-mentioned water-soluble multi-nutrition additive with eye healthcare function
Preparation Method.
A further object of the present invention is to provide the above-mentioned water-soluble multi-nutrition additives with eye healthcare function to eat
Product, drug, health care product, cosmetics, the application in feed.
The object of the invention is achieved through the following technical solutions:
A kind of water-soluble multi-nutrition additive with eye healthcare function, is grouped as by the group of following parts by weight:
1~5 part of lutein, 0.2~1 part of luteole, 1~5 part of vitamin E, 2~8 parts of hydroxypropyl-β-cyclodextrin, gather
82~95 parts of ethylene glycol.
Preferably, the water-soluble multi-nutrition additive with eye healthcare function is grouped by the group of following parts by weight
At:
3 parts of lutein, 0.6 part of luteole, 3 parts of vitamin E, 5 parts of hydroxypropyl-β-cyclodextrin, polyethylene glycol 88.4
Part.
Preferably, the molecular weight ranges of the polyethylene glycol are 2000~6000.
The preparation method of the above-mentioned water-soluble multi-nutrition additive with eye healthcare function, including following preparation step:
Precise lutein, luteole, vitamin E and hydroxypropyl-β-cyclodextrin, are added in dehydrated alcohol and stir
It is uniformly mixed, after drying is evaporated completely ethyl alcohol, the polyethylene glycol of melting is added, stirs evenly, then be placed in -4~-20 DEG C of freezings 24
~48h crushes up to the water-soluble multi-nutrition additive with eye healthcare function.
The above-mentioned water-soluble multi-nutrition additive with eye healthcare function is in food, drug, health care product, cosmetics, feeding
Application in material.
Preparation method of the invention and obtained product have the following advantages that and the utility model has the advantages that
(1) present invention can enhance the water-soluble of lutein, have good water solubility, bright-colored, the spy of strong coloring force
Point improves lutein in the intracorporal absorption efficiency of people, increases the application field of lutein, application prospect is wide；
(2) main ingredient lutein, luteole, vitamin E are natural nutrient substance, the synergistic effect of three so that
Product inoxidizability is high, improves the anti-aging ability of human body.There is certain eye healthcare function simultaneously, human body retina can be supplemented
Macular region macular pigment optical density protects macula lutea, promotes macula lutea development, prevents macular degeneration and retinal pigment degeneration.
Specific embodiment
Below with reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
Embodiment 1
A kind of water-soluble multi-nutrition additive with eye healthcare function of the present embodiment, by the component of following parts by weight
Composition: 1 part of lutein, 0.2 part of luteole, 1 part of vitamin E, 2 parts of hydroxypropyl-β-cyclodextrin, molecular weight ranges 2000
82 parts of~6000 polyethylene glycol.
The preparation method is as follows:
Precise lutein, luteole, vitamin E and hydroxypropyl-β-cyclodextrin, which are added in absolute alcohol, to be stirred
Be uniformly mixed, it is dry be evaporated completely alcohol after, the polyethylene glycol of melting is added, is uniformly mixed, then be placed in -4~-20 DEG C it is cold
Freeze 24~48h, crushes up to the water-soluble multi-nutrition additive with eye healthcare function.
Embodiment 2
A kind of water-soluble multi-nutrition additive with eye healthcare function of the present embodiment, by the component of following parts by weight
Composition: 2 parts of lutein, 0.4 part of luteole, 2 parts of vitamin E, 3.25 parts of hydroxypropyl-β-cyclodextrin, molecular weight ranges are
84.6 parts of 2000~6000 polyethylene glycol.
The preparation method is as follows:
Precise lutein, luteole, vitamin E and hydroxypropyl-β-cyclodextrin, which are added in absolute alcohol, to be stirred
Be uniformly mixed, it is dry be evaporated completely alcohol after, the polyethylene glycol of melting is added, is uniformly mixed, then be placed in -4~-20 DEG C it is cold
Freeze 24~48h, crushes up to the water-soluble multi-nutrition additive with eye healthcare function.
Embodiment 3
A kind of water-soluble multi-nutrition additive with eye healthcare function of the present embodiment, by the component of following parts by weight
Composition: 3 parts of lutein, 0.6 part of luteole, 3 parts of vitamin E, 4.5 parts of hydroxypropyl-β-cyclodextrin, molecular weight ranges are
87.2 parts of 2000~6000 polyethylene glycol.
The preparation method is as follows:
Precise lutein, luteole, vitamin E and hydroxypropyl-β-cyclodextrin, which are added in absolute alcohol, to be stirred
Be uniformly mixed, it is dry be evaporated completely alcohol after, the polyethylene glycol of melting is added, is uniformly mixed, then be placed in -4~-20 DEG C it is cold
Freeze 24~48h, crushes up to the water-soluble multi-nutrition additive with eye healthcare function.
Embodiment 4
A kind of water-soluble multi-nutrition additive with eye healthcare function of the present embodiment, by the component of following parts by weight
Composition: 4 parts of lutein, 0.8 part of luteole, 4 parts of vitamin E, 5.75 parts of hydroxypropyl-β-cyclodextrin, molecular weight ranges are
89.8 parts of 2000~6000 polyethylene glycol.
The preparation method is as follows:
Precise lutein, luteole, vitamin E and hydroxypropyl-β-cyclodextrin, which are added in absolute alcohol, to be stirred
Be uniformly mixed, it is dry be evaporated completely alcohol after, the polyethylene glycol of melting is added, is uniformly mixed, then be placed in -4~-20 DEG C it is cold
Freeze 24~48h, crushes up to the water-soluble multi-nutrition additive with eye healthcare function.
Embodiment 5
A kind of water-soluble multi-nutrition additive with eye healthcare function of the present embodiment, by the component of following parts by weight
Composition: 5 parts of lutein, 1 part of luteole, 5 parts of vitamin E, 8 parts of hydroxypropyl-β-cyclodextrin, molecular weight ranges be 2000~
95 parts of 6000 polyethylene glycol.
The preparation method is as follows:
Precise lutein, luteole, vitamin E and hydroxypropyl-β-cyclodextrin, which are added in absolute alcohol, to be stirred
Be uniformly mixed, it is dry be evaporated completely alcohol after, the polyethylene glycol of melting is added, is uniformly mixed, then be placed in -4~-20 DEG C it is cold
Freeze 24~48h, crushes up to the water-soluble multi-nutrition additive with eye healthcare function.
Embodiment 6
A kind of water-soluble multi-nutrition additive with eye healthcare function of the present embodiment, by the component of following parts by weight
Composition: 3 parts of lutein, 0.6 part of luteole, 3 parts of vitamin E, 5 parts of hydroxypropyl-β-cyclodextrin, molecular weight ranges 2000
88.4 parts of~6000 polyethylene glycol.
The preparation method is as follows:
Precise lutein, luteole, vitamin E and hydroxypropyl-β-cyclodextrin, which are added in absolute alcohol, to be stirred
Be uniformly mixed, it is dry be evaporated completely alcohol after, the polyethylene glycol of melting is added, is uniformly mixed, then be placed in -4~-20 DEG C it is cold
Freeze 24~48h, crushes up to the water-soluble multi-nutrition additive with eye healthcare function.
Additive samples Lutein solubility test obtained by above embodiments:
Its solubility is measured using Solute mass method.100ml is added and is cooled to the distilled water of room temperature after boiling in 250ml
In beaker, the sample that 20g is made in Example is added in beaker, and 25 DEG C of ± 2 DEG C of water-baths are stirred continuously.When excessive powder is longer
Between (30min) be not redissolved, then obtain the saturated solution of lutein.Heating evaporation, weighing, obtain wherein solute matter after filtering
Amount calculates the content and solubility of solute Lutein, and the results are shown in Table 1.
The solubility of each additive samples Lutein prepared by table 1 in water
By 1 result of table as it can be seen that multi-nutrition additive of the invention can significantly increase the water-soluble of lutein, with this
Lutein can be improved in the intracorporal absorption efficiency of people.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention,
It should be equivalent substitute mode, be included within the scope of the present invention.
Claims (5)
1. a kind of water-soluble multi-nutrition additive with eye healthcare function, it is characterised in that be grouped by the group of following parts by weight
At:
1~5 part of lutein, 0.2~1 part of luteole, 1~5 part of vitamin E, 2~8 parts of hydroxypropyl-β-cyclodextrin, poly- second two
82~95 parts of alcohol.
2. a kind of water-soluble multi-nutrition additive with eye healthcare function according to claim 1, it is characterised in that:
The water-soluble multi-nutrition additive with eye healthcare function is grouped as by the group of following parts by weight:
3 parts of lutein, 0.6 part of luteole, 3 parts of vitamin E, 5 parts of hydroxypropyl-β-cyclodextrin, 88.4 parts of polyethylene glycol.
3. a kind of water-soluble multi-nutrition additive with eye healthcare function according to claim 1 or 2, feature exist
In: the molecular weight ranges of the polyethylene glycol are 2000~6000.
4. a kind of preparation method of water-soluble multi-nutrition additive with eye healthcare function of any of claims 1 or 2,
It is characterized in that including following preparation step:
Precise lutein, luteole, vitamin E and hydroxypropyl-β-cyclodextrin, are added in dehydrated alcohol and are stirred
Uniformly, it is dry be evaporated completely ethyl alcohol after, the polyethylene glycol of melting is added, stirs evenly, then be placed in -4~-20 DEG C of freezings 24~
48h crushes up to the water-soluble multi-nutrition additive with eye healthcare function.
5. the water-soluble multi-nutrition additive of any of claims 1 or 2 with eye healthcare function is in food, drug, health care
Product, cosmetics, the application in feed.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110089707A (en) * | 2019-05-21 | 2019-08-06 | 华南理工大学 | A kind of nourishing jam and preparation method thereof containing water-soluble lutein |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050147648A1 (en) * | 2003-03-10 | 2005-07-07 | Gierhart Dennis L. | Zeaxanthin formulations with additional ocular-active nutrients, for protecting eye health and treating eye disorders |
| CN101507704A (en) * | 2009-03-13 | 2009-08-19 | 沈阳药科大学 | Lutein solid dispersoid and preparation method thereof |
| CN102038644A (en) * | 2010-12-23 | 2011-05-04 | 沈阳药科大学 | Lutein water-soluble powder and preparation process thereof |
| CN104337791A (en) * | 2013-08-01 | 2015-02-11 | 天津新济复兴药业科技有限公司 | Preparation method of lutein effervescent tablets |
| CN106723031A (en) * | 2016-12-12 | 2017-05-31 | 宁夏沃福百瑞枸杞产业股份有限公司 | Matrimony vine zeaxanthin, lutein, the preparation method of vitamin E soft capsule |
| CN107088186A (en) * | 2017-04-28 | 2017-08-25 | 华南理工大学 | A kind of solid dispersions containing lutein and preparation method thereof |
| CN107802619A (en) * | 2017-12-06 | 2018-03-16 | 北京市眼科研究所 | A kind of concentrate for eye health |
-
2018
- 2018-08-29 CN CN201810994813.5A patent/CN109222093A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050147648A1 (en) * | 2003-03-10 | 2005-07-07 | Gierhart Dennis L. | Zeaxanthin formulations with additional ocular-active nutrients, for protecting eye health and treating eye disorders |
| CN101507704A (en) * | 2009-03-13 | 2009-08-19 | 沈阳药科大学 | Lutein solid dispersoid and preparation method thereof |
| CN102038644A (en) * | 2010-12-23 | 2011-05-04 | 沈阳药科大学 | Lutein water-soluble powder and preparation process thereof |
| CN104337791A (en) * | 2013-08-01 | 2015-02-11 | 天津新济复兴药业科技有限公司 | Preparation method of lutein effervescent tablets |
| CN106723031A (en) * | 2016-12-12 | 2017-05-31 | 宁夏沃福百瑞枸杞产业股份有限公司 | Matrimony vine zeaxanthin, lutein, the preparation method of vitamin E soft capsule |
| CN107088186A (en) * | 2017-04-28 | 2017-08-25 | 华南理工大学 | A kind of solid dispersions containing lutein and preparation method thereof |
| CN107802619A (en) * | 2017-12-06 | 2018-03-16 | 北京市眼科研究所 | A kind of concentrate for eye health |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110089707A (en) * | 2019-05-21 | 2019-08-06 | 华南理工大学 | A kind of nourishing jam and preparation method thereof containing water-soluble lutein |
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