CN109198635A - A kind of health food and preparation method thereof with strengthen immunity function - Google Patents
A kind of health food and preparation method thereof with strengthen immunity function Download PDFInfo
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- CN109198635A CN109198635A CN201810942729.9A CN201810942729A CN109198635A CN 109198635 A CN109198635 A CN 109198635A CN 201810942729 A CN201810942729 A CN 201810942729A CN 109198635 A CN109198635 A CN 109198635A
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- fruit
- blueberry
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- sayi
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- 235000013402 health food Nutrition 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 58
- 235000003095 Vaccinium corymbosum Nutrition 0.000 claims abstract description 36
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims abstract description 36
- 235000021014 blueberries Nutrition 0.000 claims abstract description 36
- 240000000851 Vaccinium corymbosum Species 0.000 claims abstract description 26
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- 235000017524 noni Nutrition 0.000 claims abstract description 21
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- ROCUOVBWAWAQFD-UHFFFAOYSA-N velutin Chemical compound C=1C(OC)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(OC)=C1 ROCUOVBWAWAQFD-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Botany (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present invention is a kind of health food with strengthen immunity function, its main feature is that, including 2-10 parts of 2-10 parts of A Sayi fruit, honeysuckle by weight, 2-10 parts of grape seed extract, 10-65 parts of blueberry, honey 1-5.Preparation method are as follows: choose raw material, prepare A Sayi fruit, Noni fruit extracting solution, filtrate is concentrated, quintuple water progress water is added in the thick paste of concentration and sinks to obtain Ah's Say fruit, Noni fruit extracting solution, blueberry juice is prepared, deploys, sterilizing obtains product.Its product is and to innovate compatibility preferably with reasonable component through science and obtain, can play maximum function, the immunocompetence that can effectively resist free radical, improve human body, and health-care effect is obvious；Preparation method is scientific and reasonable, and manufacturing process is simple, can be realized industrialization, and application prospect is extensive.
Description
Technical field
It is a kind of health food with strengthen immunity function and its preparation side the present invention relates to food technology field
Method.
Background technique
Immunity is the defense mechanism of human body itself, is that human bioequivalence and any foreign matter of the external intrusion of elimination are (viral, thin
Bacterium etc.), it handles aging, damage, death, the own cells of denaturation and identification and processing vivo mutations cell and virus infection is thin
The ability of born of the same parents.Immunology Today thinks that immunity is human bioequivalence and the physiological reaction for excluding " dissident ".This is executed in human body
Function is immune system.
Neonatal immunity feature often shows that developing immune system is not mature enough, and function still owes perfect, not yet contacts
The various cause of diseases of extrauterine environment are crossed, miscellaneous antigenicity substance such as food proteins was not contacted yet.Pregnancy period is by logical
The influence for crossing mother's antibody of placenta makes newborn there is physiologic immunes and is low.
Immunity can be divided into nospecific immunity and specific immunity.
Immunity can be divided by the difference of its acquisition pattern: 1, congenital immunity；2, acquired immunity.
The body of hypoimmunity is easy to infected or cancer stricken, and immunity is extraordinary also to generate insalubrious knot
Fruit, such as cause allergic reaction, autoimmune disease.
A variety of causes prevents immune system from normally playing protective effect, in the case, easily incur bacterium, virus,
The infection such as fungi, therefore it is exactly liable to illness that hypoimmunity, which most directly shows,.Because of frequent illness, disappearing for body has been aggravated
Consumption, thus generally have a delicate constitution, malnutritive, apathetic, fatigue and weak, loss of appetite, sleep disturbance etc. show, give birth to
Disease, having an injection to take medicine has become homely food.It is sick every time to be lot more time to restore, and usually recurrent exerbation.Grow this
It will lead to physical and intellectual depauperation in the past, and also easily induced major disease.
Underlying causes are that hypoimmunity or immunity are unsound.When immune function of human body imbalance or immune system not
When perfecting, following point will recurrent exerbation: flu recurrent exerbation, tonsillitis recurrent exerbation, asthma recurrent exerbation, bronchus
Scorching recurrent exerbation, pneumonia recurrent exerbation, diarrhea recurrent exerbation, so necessarily should not be overlooked.
The intracorporal endogenous peptide shortage of people can cause immunologic hypofunction, and due to immunologic hypofunction, non resistance is presented in body
State, common cold virus are taken advantage of a weak point, and are complicated by infection, the especially concurrent infection of influenza, the state of an illness is extremely serious, the death rate
Also very high.With the progress of Immunology Today, people gradually fully realize peptide and immune relationship.Peptide in human body is not
It can cause that Development of Immune Organs is complete, atrophy completely, all to cellular immunity, humoral immunity, complement function and phagocytosis etc.
It has an important influence.
Summary of the invention
The applicant based on inventive concept are as follows: A Sayi fruit, the also known as Brazilian certain kind of berries, fruit on palm is round,
About 25 millimeters of black purple, perimeter.Pericarp is thin and succulence, thickness are about 1 millimeter.In Brazilian Amazon River basin, A Sayi slurry
Fruit (acai berry) is considered as food picking by local resident, and palm is also acknowledged as most important floristics.Because Ah
Say berry is at their diet chief component, and according to scientific analysis, local populace's growth is absorbed nourishment in ingredient up to
42% derives from A Sayi berry.University of Arkansas of the U.S. on " nutrition is biochemical " periodical, reported for the first time on November 30th, 2011
Road Brazil certain kind of berries is containing potent anti-inflammatory and antioxidant Wei Luting (velutin).When macrophage is exposed to lipopolysaccharides, can generate
Tumor necrosis factor α and white plain 6 both anti-inflammatory compounds that are situated between.The potent anti-inflammatory flavones dimension dew isolated in Brazilian certain kind of berries pulp
Spit of fland can prevent the signal in downstream from transmitting through tumor necrosis factor α and Jie white plain 6 is inhibited.Montana, United States produce university in
A paper is delivered on 2 28th, 2011 on " PLoS One " periodical, the polysaccharide that the Brazilian certain kind of berries of report is isolated can induce congenital
Immune response.In the peripheral blood mononuclear ball of the mankind of culture, mouse and ox, Brazilian certain kind of berries polysaccharide component induces powerful y δ T thin
Born of the same parents activate phenomenon.Maximum Brazil's certain kind of berries polysaccharide, it is most active in the activation of bone marrow cell and y delta T cells in vitro.In vivo, Brazilian
Certain kind of berries polysaccharide can induce the generation of the focusing of bone marrow cell and the white element IL-12 that is situated between.It is bright that experiment shows that A Sayi fruit (the Brazilian certain kind of berries) has
Aobvious strengthen immunity function.
Honeysuckle is the dry flower of caprifoliaceae plant or with the flower just opened, sweet in flavor, cold in nature, is Chinese medicine common medicine, has
The effect of clearing heat and detoxicating, wind-heat dissipating, cure mainly carbuncle swells furunculosis, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, warm disease heating etc.
Disease.
Luo Zhonghua etc. experiments have shown that, honeysuckle, which has, promotes leucocyte and inflammatory cell phagocytic function, and can reduce cavy T
Cell a- naphthyl acetate esterase (ANAE) percentage, reducing neutrophil leucocyte (PMN) secreted in vitro has recovery macrophage function,
It improves lymphocyte function, the effects of significantly increasing the generation of IL-2 while showing honeysuckle not only and can improve damaged cell to exempt from
Epidemic disease ability has also reconciled the function of suppressed lymphocytic emiocytosis cell factor not only to specificity and nonspecific cell
It is immunized and also there is preferable conciliation to act on specific humoral immunity function.
Grape seed extract is that isolated a kind of polyphenols is extracted from grape pip, mainly by procyanidine,
Catechin, epicatechin, gallic acid, the polyphenols such as L-Epicatechin gallate composition.
Mao Tingting is in order to study grape pip procyanidin (Procyanidin from Grape seed, GSP) to rat spleen
The influence of dirty lymphocyte and hepatocyte growth and activation discloses the mechanism of action that GSP improves immunity of organism performance.Test uses
The GSP culture solution and rat spleen lymphocytes of different final concentrations are educated altogether with rat hepatocytes system IAR.After 12,24,48h, use
Microplate reader measures the OD value in each hole at 490nm.As the result is shown: grape pip procyanidin can promote the spleen of In Cultured Rat
Dirty lymphocyte and hepatocyte proliferation activity have the function of improving cellular anti-oxidant and cellular immunity.
Shu Xiaochen etc. is the immunoregulation effect for evaluating grape seed extract, detects its immune indexes using mouse inbred lines
Variation.Test result shows: grape seed polyphenols have certain immunoloregulation function.
Week it is gorgeous it is equal 50 adult KM mouse are randomly divided into 5 groups, solvent control group, SEM control group, basic, normal, high dose of SEM+
Amount group PC protection group, solvent control group, stomach-filling deionized water；SEM contamination group, the last fortnight stomach-filling 56.25mg/kg.bwSEM are molten
Liquid, rear 4 weeks stomach-filling deionized waters；Basic, normal, high dosage PC protection group, first 2 weeks equal stomach-filling 56.25mg/kg.bwSEM solution, rear 4
Week stomach-filling 100,200,400mg/kg.bwPC solution respectively.After last stomach-filling for 24 hours, mouse is put to death after plucking eyeball blood sampling, measures phase
Close Testing index.The result shows that: SEM contamination group NK cells in mice activity, the phagocytic activity of peritoneal macrophage, antibody are formed carefully
Born of the same parents' number, lymphocyte transformation ability (SI) are below solvent control group (P < 0.05)；And middle and high dosage PC protection group mouse NK
Cell activity, the phagocytic activity of abdominal cavity phagocytic, AFC and SI are above SEM contamination group, the statistically significant (P of difference
< 0.05).Conclusion: the procyanidine for giving doses can be improved immune function of mice, cause experiment mice to exempt from semicarbazides
The damage of epidemic disease cell activity has good restitution.
Blueberry is Ericaceae blueberry plant (Vaccinium sp.), is removed in fruit containing conventional sugar, acid and Vc
Outside, rich in the minerals member such as VE, VA, VB, SOD, arbutin, protein, anthocyanin, credit fiber and K, Fe, Zn, Ca abundant
Element.It not only has good nutrition health-care functions, also prevents cranial nerve aging, heart tonifying, anticancer, softening blood vessel, adjusts
Blood pressure, delaying senility, the functions such as enhancing human immunity.Therefore, FAO (Food and Agriculture Organization of the United Nation) be classified as five big healthy food it
One[1]。
Yan Ting etc. studies blueberry to the immunoregulation effect of mouse.Method: every group of mouse respectively oral stomach-filling give 54,
108,325mg/(kg.bw) blueberry extract and after aqua sterilisa 30 days, observe its weight, measure its Immune Organs Index, leaching
Bar ability of cell proliferation, mouse delayed allergy, serum hemolysin, the phagocytic function of phagocyte and NK cell activity.
As a result: 325mg/(kg.bw) group can increase mouse auricular concha weight, enhancing lymphopoiesis ability, improve mouse carbonic clearance
Ability improves NK cells in mice and macrophage activity；108mg/(kg.bw) group can increase mouse auricular concha weight, serum half
Number hemolysis value；54mg/(kg.bw) NK cells in mice activity can be improved in group.Conclusion: blueberry has enhancing immune function of mice
It influences.
Pan Lihua passes through the extraction process of experimental study blueberry anthocyanin, and inquires into its immunocompetence.Experiment shows: blueberry
Anthocyanidin has facilitation to the proliferation of splenic lymphocytes, and with the extension of the increase of anthocyanidin quality depth and incubation time
And enhance.Meanwhile research is it is also shown that blueberry anthocyanin can not only promote Spleen cell proliferation, while ConA stimulation can also be cooperateed with small
Mouse beer spoiled bacteria TNF secretion-α and IL-2 inflammatory factor.Has the function of strengthen immunity.
The present invention also selects honey to act on sweetener, meanwhile, it is more preferably big well-established because its flavor is natural.
An object of the present invention is, to the existing food with strengthen immunity function carry out science preferably and rationally
Component so that its is played maximum function, free radical can effectively be resisted, improve by providing one kind by innovating compatibility
The good health food with strengthen immunity function of human immunological competence, health-care effect.
Realize one of the object of the invention the technical solution adopted is that, a kind of health food with strengthen immunity function,
It is characterized by comprising following raw materials accordings by weight:
Ah Say fruit 2-10
Honeysuckle 2-10
Grape seed extract 2-10
Blueberry 10-65
Honey 1-5.
The second purpose of the invention is to provide a kind of scientific and reasonable, manufacturing process is simple, can be realized industrialization, applies
The good health food preparation method with strengthen immunity function of effect.
Realize the object of the invention two the technical solution adopted is that, a kind of health food system with strengthen immunity function
Preparation Method, characterized in that
(1) choose raw material: progress component by weight is chosen 2-10 parts of A Sayi fruit, 2-10 parts of Noni fruit, grape pip and is mentioned
Take 2-10 parts of object, 10-65 parts of blueberry, 1-5 parts of honey it is spare；
(2) A Sayi fruit, Noni fruit extracting solution are prepared: A Sayi fruit and Noni fruit are put into extraction by the amount that step (1) provides
In tank, 6 times of 70% ethyl alcohol of A Sayi fruit and Noni fruit total amount being added and extracts 6 times, 85 DEG C of temperature, each time is respectively 45min,
It is filtered after extracting solution is merged, obtains filtrate and filter residue, filter residue discards；
(3) it puts the filtrate into vacuum extraction tank, carries out reduced vacuum, 60 DEG C, -0.07Mpa concentration, being concentrated into relative density is
1.10(50 DEG C is surveyed) thick paste is obtained, it leaves and takes spare；
(4) thick paste is put into receiver, quintuple water progress water is added and sinks, insoluble matter is discarded, Ah's Say fruit, Noni fruit are obtained
Extracting solution；
(5) prepare blueberry juice: the amount for providing blueberry by step (1) being put into juice extractor and is squeezed the juice, after juicing by blueberry juice into
3000 turns of row/min, 5min centrifuging treatment obtains blueberry juice after filtering；
(6) it deploys: the blueberry juice of the A Sayi fruit of step (4), Noni fruit extracting solution and step (5) being merged, by step (1)
Amount honey, grape seed extract and suitable purified water is added, with filling after the filtering of plate and frame filter；
(7) it sterilizes: using board-like sterilizer, setting sterilization temperature as 117 DEG C -123 DEG C；Sterilization time is that 20s sterilizes
Processing, obtains product after the assay was approved.
There is the present invention substantive distinguishing features outstanding and marked improvement and good effect to be embodied in compared with prior art:
1. due to, preferably with reasonable component, and innovating the obtained product of compatibility using science, maximum function can be played
Effect, the immunocompetence that can effectively resist free radical, improve human body, health-care effect are obvious；
2. product shows through disease prevention and control center of Jilin Province toxicity and functional experiment testing result: function is significant, safe nothing
Poison；
3. the preparation method of this product is scientific and reasonable, manufacturing process is simple, can be realized industrialization, and application prospect is extensive.
Specific embodiment
Below with embodiment, the present invention is described in detail.
The health food with strengthen immunity function of embodiment 1, including following raw materials according by weight:
Ah's Say fruit 2
Honeysuckle 2
Grape seed extract 2
Blueberry 10
Honey 1.
The health food with strengthen immunity function of embodiment 2, including following raw materials according by weight:
Ah's Say fruit 2
Honeysuckle 10
Grape seed extract 6
Blueberry 50
Honey 5.
The health food with strengthen immunity function of embodiment 3, including following raw materials according by weight:
Ah's Say fruit 4
Honeysuckle 8
Grape seed extract 4
Blueberry 36
Honey 4.
The health food with strengthen immunity function of embodiment 5, including following raw materials according by weight:
Ah's Say fruit 6
Honeysuckle 6
Grape seed extract 2
Blueberry 23
Honey 3.
The health food with strengthen immunity function of embodiment 6, including following raw materials according by weight:
Ah's Say fruit 8
Honeysuckle 4
Grape seed extract 8
Blueberry 10
Honey 2.
The health food with strengthen immunity function of embodiment 7, including following raw materials according by weight:
Ah's Say fruit 10
Honeysuckle 2
Grape seed extract 10
Blueberry 65
Honey 1.
The health food with strengthen immunity function of embodiment 8, including following raw materials according by weight:
Ah's Say fruit 6
Honeysuckle 4
Grape seed extract 2
Blueberry 36
Honey 5.
The health food with strengthen immunity function of embodiment 9, including following raw materials according by weight:
Ah's Say fruit 8
Honeysuckle 4
Grape seed extract 10
Blueberry 10
Honey 4.
Product specification: 50ml/ bottles.
Eating method and amount: twice daily, one bottle every time.
Suitable population: fatiguability person.
It is not suitable for crowd: children, Pregnant and lactant women.
Indicate sexual element and content: every 100ml contains: total saposins 7.6g.
A kind of health food preparation method with strengthen immunity function is described by taking embodiment 1 as an example,
(1) choose raw material: progress component by weight is chosen 2-10 parts of A Sayi fruit, 2-10 parts of Noni fruit, grape pip and is extracted
2-10 parts of object, 10-65 parts of blueberry, 1-5 parts of honey it is spare；
(2) A Sayi fruit, Noni fruit extracting solution are prepared: A Sayi fruit and Noni fruit are put into extraction by the amount that step (1) provides
In tank, 6 times of 70% ethyl alcohol of A Sayi fruit and Noni fruit total amount being added and extracts 6 times, 85 DEG C of temperature, each time is respectively 45min,
It is filtered after extracting solution is merged, obtains filtrate and filter residue, filter residue discards；
(3) it puts the filtrate into vacuum extraction tank, carries out reduced vacuum, 60 DEG C, -0.07Mpa concentration, being concentrated into relative density is
1.10(50 DEG C is surveyed) thick paste is obtained, it leaves and takes spare；
(4) thick paste is put into receiver, quintuple water progress water is added and sinks, insoluble matter is discarded, Ah's Say fruit, Noni fruit are obtained
Extracting solution；
(5) prepare blueberry juice: the amount for providing blueberry by step (1) being put into juice extractor and is squeezed the juice, after juicing by blueberry juice into
3000 turns of row/min, 5min centrifuging treatment obtains blueberry juice after filtering；
(6) it deploys: the blueberry juice of the A Sayi fruit of step (4), Noni fruit extracting solution and step (5) being merged, by step (1)
Amount honey, grape seed extract and suitable purified water is added, with filling after the filtering of plate and frame filter；
(7) it sterilizes: using board-like sterilizer, setting sterilization temperature as 117 DEG C -123 DEG C；Sterilization time is that 20s sterilizes
Processing, obtains product after the assay was approved.
Specific embodiments of the present invention are only intended to clearly illustrate example, and not to the limit of embodiment
It is fixed, for those of ordinary skill in the art, it can also make on the basis of the above description other various forms of
Variation changes, here without being exhaustive to all embodiments, and obvious variation extended from this or
It changes still within the protection scope of the invention.
Claims (2)
1. a kind of health food with strengthen immunity function, it is characterised in that: including following raw materials according by weight:
Ah Say fruit 2-10
Noni fruit 2-10
Grape seed extract 2-10
Blueberry 10-65
Honey 1-5.
2. a kind of health food preparation method with strengthen immunity function, characterized in that it the following steps are included:
(1) choose raw material: progress component by weight is chosen 2-10 parts of A Sayi fruit, 2-10 parts of Noni fruit, grape pip and is extracted
2-10 parts of object, 10-65 parts of blueberry, 1-5 parts of honey it is spare；
(2) A Sayi fruit, Noni fruit extracting solution are prepared: A Sayi fruit and Noni fruit are put into extraction by the amount that step (1) provides
In tank, 6 times of 70% ethyl alcohol of A Sayi fruit and Noni fruit total amount being added and extracts 6 times, 85 DEG C of temperature, each time is respectively 45min,
It is filtered after extracting solution is merged, obtains filtrate and filter residue, filter residue discards；
(3) it puts the filtrate into vacuum extraction tank, carries out reduced vacuum, 60 DEG C, -0.07Mpa concentration, being concentrated into relative density is
1.10(50 DEG C is surveyed) thick paste is obtained, it leaves and takes spare；
(4) thick paste is put into receiver, quintuple water progress water is added and sinks, insoluble matter is discarded, Ah's Say fruit, Noni fruit are obtained
Extracting solution；
(5) prepare blueberry juice: the amount for providing blueberry by step (1) being put into juice extractor and is squeezed the juice, after juicing by blueberry juice into
3000 turns of row/min, 5min centrifuging treatment obtains blueberry juice after filtering；
(6) it deploys: the blueberry juice of the A Sayi fruit of step (4), Noni fruit extracting solution and step (5) being merged, by step (1)
Amount honey, grape seed extract and suitable purified water is added, with filling after the filtering of plate and frame filter；
(7) it sterilizes: using board-like sterilizer, setting sterilization temperature as 117 DEG C -123 DEG C；Sterilization time is that 20s sterilizes
Processing, obtains product after the assay was approved.
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| US11628195B2 (en) * | 2019-06-03 | 2023-04-18 | Cosmax Nbt, Inc. | Method for preparing iridoid-rich noni fruit extract or fraction thereof, method for preparing immune-enhancing active material-rich noni fruit extract or fraction thereof and use of noni fruit extract or fraction thereof |
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| US11628195B2 (en) * | 2019-06-03 | 2023-04-18 | Cosmax Nbt, Inc. | Method for preparing iridoid-rich noni fruit extract or fraction thereof, method for preparing immune-enhancing active material-rich noni fruit extract or fraction thereof and use of noni fruit extract or fraction thereof |
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