CN109198206A - Radix scutellariae quaternary ammonium salt feed addictive - Google Patents
Radix scutellariae quaternary ammonium salt feed addictive Download PDFInfo
- Publication number
- CN109198206A CN109198206A CN201710549847.9A CN201710549847A CN109198206A CN 109198206 A CN109198206 A CN 109198206A CN 201710549847 A CN201710549847 A CN 201710549847A CN 109198206 A CN109198206 A CN 109198206A
- Authority
- CN
- China
- Prior art keywords
- radix scutellariae
- quaternary ammonium
- ammonium salt
- feed addictive
- minutes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/121—Heterocyclic compounds containing oxygen or sulfur as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
Abstract
Radix scutellariae quaternary ammonium salt feed addictive, it is related to a kind of animal additive with Chinese herbal medicine, and in particular to a kind of animal radix scutellariae quaternary ammonium salt feed addictive.First by Baical Skullcap root P.E mixed carbonic acid hydrogen calcium solution, adjusting pH value is 9.0, and above-mentioned miscible solution is stirred 120 minutes and filtered, and Baical Skullcap root P.E filtered fluid beta-glucuronic acid stirs 120 minutes back spins and boils off impurity, forms baicalein dry matter；1 milliliter of baicalein and 0.4 milliliter of 12 alkyl trimethyl ammonium chloride cation are blended under pH value is 7.0 stirring 120 minutes, after 12 alkyl trimethyl radix scutellariae quaternary ammonium salts react 30 minutes with calcium bicarbonate, it prevents from crushing in 0-5 degree low temperature drying, radix scutellariae quaternary ammonium salt soluble powder being made；Then radix scutellariae quaternary ammonium salt feed addictive is made in mixing silica.Antibacterial activity of the present invention is external and internal improvement effect, negative bacterium and positive bacteria improve, and minimal inhibitory concentration improves.
Description
Technical field
A kind of the present invention relates to a kind of animal additive with Chinese herbal medicine, and in particular to animal radix scutellariae quaternary ammonium salt feed
Additive.
Background technique
Radix scutellariae, alias Radix Scutellariae, tsuchikane tea root are lamiaceae labiatae scutellaria herbaceos perennials；Meat rhizome is plump, leaf
Hard papery, lanceolar to wire lanceolar, raceme basidixed on stem and branch, corolla is purple, purplish red to blue, and filigree is flat,
Style is elongated, and floral disc is cyclic annular, ovary brown, pyrene ovoid, 7~September of flowering fruit bearing stage.
The root of radix scutellariae is used as medicine, bitter, cold in nature, there is heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention and other effects.Cure mainly warm
Disease, the infection of the upper respiratory tract, cough with lung heat, neonatal jaundice caused by dampness-heat, pneumonia, dysentery, hemoptysis, hot eyes, threatened abortion, hypertension, carbuncle swells furuncle
The diseases such as sore.The clinical antibiotic property of radix scutellariae is better than the coptis, and does not develop drug resistance.
Summary of the invention
In view of the defects and deficiencies of the prior art, the present invention intends to provide a kind of radix scutellariae quaternary ammonium salt feed additions
Agent, it can be improved, and antibacterial activity is external and internal improvement effect, negative bacterium and positive bacteria improve, and minimal inhibitory concentration improves.
To achieve the above object, the present invention is using following process technology scheme: first by Baical Skullcap root P.E mixed carbonic acid
Hydrogen calcium solution, adjustment pH value are 9.0, and above-mentioned miscible solution is stirred 120 minutes and filtered, Baical Skullcap root P.E filtered fluid β-grape
Uronic acid stirs 120 minutes back spins and boils off impurity, forms baicalein dry matter；By 1 milliliter of baicalein and 0.4 milliliter of 12 alkyl three
Methyl chloride ammonium cation is blended under pH value is 7.0 stirring 120 minutes, 12 alkyl trimethyl radix scutellariae quaternary ammonium salts and calcium bicarbonate
After reaction 30 minutes, prevent from crushing in 0-5 degree low temperature drying, radix scutellariae quaternary ammonium salt soluble powder being made；Then silica is mixed
Radix scutellariae quaternary ammonium salt feed addictive is made.
Scutelloside, which is extracted into baicalein radix scutellariae quaternary ammonium salt is further made, can be improved the effect of baicalein antibacterial anti-inflammatory, and
Guarantee the stability of this body structure of radix scutellariae, it is safe and nontoxic, meet veterinary drug scope specification, soluble powder, which is made, can be used for animal mouthful
Liquid is taken applied to antibacterial anti-inflammatory.Additive use, which is made, can prevent young dynamic storage object bacterial diarrhea, promote growth of animal.
The content of baicalin of the Baical Skullcap root P.E is 80%.
The molecular formula of the baicalein dry matter is C34H52CINO5, molecular weight 590.2.
Main component of the present invention is the restoration precursor that scutelloside is baicalein, is easy by flora enzyme GRD beta-glucuronidase
It is hydrolyzed to baicalein, baicalein gram is reduced to rapidly scutelloside in vivo, and current market sales of Baical Skullcap root P.E is mostly Huang
The main component of a kind of reed mentioned in ancient books glycosides, antibacterial effect and bioavilability are all undesirable, and the present invention mainly passes through enzymatic method Baical Skullcap root P.E
The purifying of main component scutelloside is baicalein, and the stability and antibacterial activity of baicalein are improved by cationic activation technique,
Reach substitute antibiotics using effect.
Antibacterial activity of the present invention is external and internal improvement effect, negative bacterium and positive bacteria improve, and minimal inhibitory concentration improves.
Specific embodiment
The process technology scheme that present embodiment uses is: first by Baical Skullcap root P.E mixed carbonic acid hydrogen calcium solution,
Adjusting pH value is 9.0, and above-mentioned miscible solution is stirred 120 minutes and filtered, Baical Skullcap root P.E filtered fluid beta-glucuronic acid stirs
It mixes 120 minutes back spins and boils off impurity, form baicalein dry matter；By 1 milliliter of baicalein and 0.4 milliliter of 12 alkyl trimethyl chlorination
Ammonium cation is blended under pH value is 7.0 stirring 120 minutes, and 12 alkyl trimethyl radix scutellariae quaternary ammonium salts react 30 points with calcium bicarbonate
Zhong Hou prevents from crushing in 0-5 degree low temperature drying, radix scutellariae quaternary ammonium salt soluble powder being made；Then radix scutellariae is made in mixing silica
Quaternary ammonium salt feed addictive.
Scutelloside, which is extracted into baicalein radix scutellariae quaternary ammonium salt is further made, can be improved the effect of baicalein antibacterial anti-inflammatory, and
Guarantee the stability of this body structure of radix scutellariae, it is safe and nontoxic, meet veterinary drug scope specification, soluble powder, which is made, can be used for animal mouthful
Liquid is taken applied to antibacterial anti-inflammatory.Additive use, which is made, can prevent young dynamic storage object bacterial diarrhea, promote growth of animal.
The content of baicalin of the Baical Skullcap root P.E is 80%.
The molecular formula of the baicalein dry matter is C34H52CINO5, molecular weight 590.2.
The purifying of Chinese herbal medicine Baical Skullcap root P.E and cationic modification technique are fabricated to feed addictive in the present invention, in Shanxi
Treatment diarrhea experiment is done to growing and fattening pigs in pig farm, and wherein diarrhea is serious 26 in 56 pig houses within first day, and this product is blended in
It is treated in daily ration by addition 200g per ton, is taken an evident turn for the better in three days, controlled in daily ration by 300g per ton addition within the 4th day
It treats by the 6th day and is almost recovered, start within the 8th day to restore daily ration, diarrhea no longer occur in no longer addition this product, 56 growing and fattening pigs.
Main component of the present invention is the restoration precursor that scutelloside is baicalein, is easy by flora enzyme GRD beta-glucuronidase
It is hydrolyzed to baicalein, baicalein gram is reduced to rapidly scutelloside in vivo, and current market sales of Baical Skullcap root P.E is mostly Huang
The main component of a kind of reed mentioned in ancient books glycosides, antibacterial effect and bioavilability are all undesirable, and the present invention mainly passes through enzymatic method Baical Skullcap root P.E
The purifying of main component scutelloside is baicalein, and the stability and antibacterial activity of baicalein are improved by cationic activation technique,
Reach substitute antibiotics using effect.
Antibacterial activity of the present invention is external and internal improvement effect, negative bacterium and positive bacteria improve, and minimal inhibitory concentration improves.
The above is only used to illustrate the technical scheme of the present invention and not to limit it, and those of ordinary skill in the art are to this hair
The other modifications or equivalent replacement that bright technical solution is made, as long as it does not depart from the spirit and scope of the technical scheme of the present invention,
It is intended to be within the scope of the claims of the invention.
Claims (3)
1. radix scutellariae quaternary ammonium salt feed addictive, it is characterised in that: first by Baical Skullcap root P.E mixed carbonic acid hydrogen calcium solution, adjust PH
Value is 9.0, and above-mentioned miscible solution is stirred 120 minutes and filtered, Baical Skullcap root P.E filtered fluid beta-glucuronic acid stirs 120 points
Clock back spin boils off impurity, forms baicalein dry matter；By 1 milliliter of baicalein and 0.4 milliliter of 12 alkyl trimethyl ammonium chloride sun from
Son is blended under pH value is 7.0 stirring 120 minutes, after 12 alkyl trimethyl radix scutellariae quaternary ammonium salts react 30 minutes with calcium bicarbonate,
It prevents from crushing in 0-5 degree low temperature drying, radix scutellariae quaternary ammonium salt soluble powder being made；Then radix scutellariae quaternary ammonium is made in mixing silica
Salt feed addictive.
2. radix scutellariae quaternary ammonium salt feed addictive according to claim 1, it is characterised in that: the Huang of the Baical Skullcap root P.E
A kind of reed mentioned in ancient books glycosides content is 80%.
3. radix scutellariae quaternary ammonium salt feed addictive according to claim 1, it is characterised in that: the baicalein dry matter
Molecular formula is C34H52CINO5, molecular weight 590.2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710549847.9A CN109198206A (en) | 2017-07-07 | 2017-07-07 | Radix scutellariae quaternary ammonium salt feed addictive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710549847.9A CN109198206A (en) | 2017-07-07 | 2017-07-07 | Radix scutellariae quaternary ammonium salt feed addictive |
Publications (1)
| Publication Number | Publication Date |
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| CN109198206A true CN109198206A (en) | 2019-01-15 |
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| CN201710549847.9A Pending CN109198206A (en) | 2017-07-07 | 2017-07-07 | Radix scutellariae quaternary ammonium salt feed addictive |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020031608A (en) * | 2000-10-19 | 2002-05-03 | 이응세 | Scutellariae Radix extracts showing a good anti-microbial effect, preparing methods thereof and pharmaceutical compositions containing the same |
| CN101491295A (en) * | 2008-01-23 | 2009-07-29 | 北京因科瑞斯医药科技有限公司 | Natural feed additive and preparation method thereof |
| CN102919539A (en) * | 2012-11-12 | 2013-02-13 | 哈尔滨市新诚誉华饲料有限公司 | Fermented scutellaria baicalensis feed additive |
| CN105238826A (en) * | 2015-11-20 | 2016-01-13 | 江苏康缘药业股份有限公司 | Application of beta-glucosidase and method for preparing baicalein through beta-glucosidase |
| CN106728000A (en) * | 2016-11-24 | 2017-05-31 | 湖南美可达生物资源股份有限公司 | A kind of macleaya cordata baikal skullcap root composition and its application for veterinary drug or medicated feed additive |
-
2017
- 2017-07-07 CN CN201710549847.9A patent/CN109198206A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20020031608A (en) * | 2000-10-19 | 2002-05-03 | 이응세 | Scutellariae Radix extracts showing a good anti-microbial effect, preparing methods thereof and pharmaceutical compositions containing the same |
| CN101491295A (en) * | 2008-01-23 | 2009-07-29 | 北京因科瑞斯医药科技有限公司 | Natural feed additive and preparation method thereof |
| CN102919539A (en) * | 2012-11-12 | 2013-02-13 | 哈尔滨市新诚誉华饲料有限公司 | Fermented scutellaria baicalensis feed additive |
| CN105238826A (en) * | 2015-11-20 | 2016-01-13 | 江苏康缘药业股份有限公司 | Application of beta-glucosidase and method for preparing baicalein through beta-glucosidase |
| CN106728000A (en) * | 2016-11-24 | 2017-05-31 | 湖南美可达生物资源股份有限公司 | A kind of macleaya cordata baikal skullcap root composition and its application for veterinary drug or medicated feed additive |
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| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20190115 |
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